88 results on '"Bubb K"'
Search Results
2. Lactulose Lowers Systolic Blood Pressure
- Author
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Bonaddio, J., primary, Bubb, K., additional, Nicholls, S., additional, and White, A., additional
- Published
- 2023
- Full Text
- View/download PDF
3. Single cell RNA sequencing identifies mitochondrial respiration as a key factor contributing to extracellular matrix integrity
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Bubb, K, additional, Holzer, T, additional, Nolte, J L, additional, Krüger, M, additional, Wilson, R, additional, Schlötzer-Schrehardt, U, additional, Brinckmann, J, additional, Altmüller, J, additional, Aszodi, A, additional, Fleischhauer, L, additional, Clausen-Schaumann, H, additional, Probst, K, additional, and Brachvogel, B, additional
- Published
- 2021
- Full Text
- View/download PDF
4. EFFECTS OF NITROGEN FERTILISATION AND WEED CONTROL ON NUTRITION AND GROWTH OF A FOUR-YEAR-OLD ARAUCARIA CUNNINGHAMII PLANTATION IN SUBTROPICAL AUSTRALIA
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Xu, Z. H., Bubb, K. A., and Simpson, J. A.
- Published
- 2002
5. NITROGEN RESPONSE AND ¹⁵N-LABELLED FERTILISER RECOVERY BY HOOP PINE SEEDLINGS GROWN UNDER GLASSHOUSE CONDITIONS
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Bubb, K. A., Xu, Z. H., Simpson, J. A., and Saffigna, P. G.
- Published
- 2001
6. FXYD1 Protects Against Pressure-Overload Cardiac Remodelling and Fibrosis
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Wu, D., primary, Besnier, M., additional, Bubb, K., additional, Di Bartolo, B., additional, Tang, O., additional, and Figtree, G., additional
- Published
- 2021
- Full Text
- View/download PDF
7. CRISPR Mutation of a Single Reactive Cysteine of the Na+/K+ Pump’s ß1-Subunit Abolishes Redox-Dependent Cardiac Hypertrophy and Fibrosis
- Author
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Wu, D., primary, Bubb, K., additional, Besnier, M., additional, Tang, O., additional, Di Bartolo, B., additional, and Figtree, G., additional
- Published
- 2021
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8. Cardiac health in the reduced uterine perfusion pressure rat model of preeclampsia
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Richard, C, Chhor, M, Glenn Ong, ZH, Bubb, K, and McClements, L
- Subjects
1103 Clinical Sciences, 1114 Paediatrics and Reproductive Medicine, 1117 Public Health and Health Services ,Pediatrics - Abstract
Background: Preeclampsia (PE) is a life-threatening disorder without treatment options except delivery of the baby and the placenta, often pre-term. PE increases the risk of subsequent cardiovascular complications in both mothers and offspring. In this study, our aim was to investigate the associated cardiac health in the reduced uterine perfusion pressure (RUPP) rat model of PE. Methods: The RUPP model was induced in pregnant rats (GD14) by applying silver clips around aorta and uterine arteries reducing the blood flow to the uterus by ~40%. On GD19, echocardiography was performed and blood pressure measured. At the end of the experiment, maternal organs were harvested and processed for downstream analyses. Results: Whilst RUPP rats had increased systolic pressure (sham 113 ± 1 vs RUPP 125 ± 2 mmHg, n=8, P
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- 2020
9. 746 Patient-Derived Endothelial Progenitor Cell Growth Characteristics and Molecular Phenotypes in Patients With Coronary Artery Disease
- Author
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Finemore, M., primary, Yu, C., additional, Kott, K., additional, Vernon, S., additional, Di Bartolo, B., additional, Bubb, K., additional, and Figtree, G., additional
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- 2020
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10. 001 The Utility of the P2X7 Receptor as a Diagnostic and Therapeutic Target in Atherosclerosis and Efficacy of a Novel P2X7 Receptor Antagonist
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Hansen, T., primary, Bubb, K., additional, McGuire, H., additional, Kim, T., additional, Vernon, S., additional, Kott, K., additional, Yang, J., additional, Kassiou, M., additional, and Figtree, G., additional
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- 2020
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11. VITAMIN D INSUFFICIENCY IN UTERO AND EARLY LIFE CAUSES REGIONAL IMPAIRMENT IN VASCULAR REACTIVITY AND ALTERS VASCULAR COMPLIANCE
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Bubb, K J, Kett, M M, Morley, R, Wintour, E M, Parkington, H C, and Tare, M
- Published
- 2008
12. Growth response to fertilisation and recovery of 15N-labelled fertiliser by young hoop pine plantations of subtropical Australia
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Bubb, K. A., Xu, Z. H., Simpson, J. A., and Safligna, P. G.
- Published
- 1999
13. 238Protective actions of substance p in diabetes induced cardiac fibrosis
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Widiapradja, A, primary, Manteufel, E J, additional, Kolb, L L, additional, Imig, J D, additional, Yu, C, additional, Bubb, K J, additional, Figtree, G A, additional, and Levick, S P, additional
- Published
- 2018
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14. Vegetative filter strips to control sediment movement in forest plantations: validation of a simple model using field data
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Loch, R. J., Espigares, T., Costantini, A., Garthe, R., and Bubb, K.
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Sediment control -- Research ,Forest management -- Research ,Agricultural industry ,Earth sciences - Abstract
Abstract A field study of sediment movement through vegetative barriers was carried out to assess the sediment-trapping effectiveness of vegetative barrier types typically used in forest forest plantation management in [...]
- Published
- 1999
15. Silencing of FXYD1 Uncouples eNOS in Human Umbilical Vein Endothelial Cells
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Tang, O., primary, Huang, T., additional, Bubb, K., additional, Hansen, T., additional, and Figtree, G., additional
- Published
- 2016
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16. The β3 Adrenergic Receptor Agonist, CL 216, 343, Promotes Angiogenesis
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Bubb, K., primary, Tang, O., additional, Hansen, T., additional, Huang, T., additional, and Figtree, G., additional
- Published
- 2016
- Full Text
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17. FXYD1 is an Endogenous Protector Against Redox-Mediated Vascular Dysfunction
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Hansen, T., primary, Tang, O., additional, Figtree, G., additional, Bubb, K., additional, and Sweadner, K., additional
- Published
- 2016
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18. Poster session 2
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Perez-Pomares, J. M., primary, Ruiz-Villalba, A., additional, Ziogas, A., additional, Segovia, J. C., additional, Ehrbar, M., additional, Munoz-Chapuli, R., additional, De La Rosa, A., additional, Dominguez, J. N., additional, Hove-Madsen, L., additional, Sankova, B., additional, Sedmera, D., additional, Franco, D., additional, Aranega Jimenez, A., additional, Babaeva, G., additional, Chizh, N., additional, Galchenko, S., additional, Sandomirsky, B., additional, Schwarzl, M., additional, Seiler, S., additional, Steendijk, P., additional, Huber, S., additional, Maechler, H., additional, Truschnig-Wilders, M., additional, Pieske, B., additional, Post, H., additional, Simrick, S., additional, Kreutzer, R., additional, Rao, C., additional, Terracciano, C. M., additional, Kirchhof, P., additional, Fabritz, L., additional, Brand, T., additional, Theveniau-Ruissy, M., additional, Parisot, P., additional, Francou, A., additional, Saint-Michel, E., additional, Mesbah, K., additional, Kelly, R. G., additional, Wu, H.-T., additional, Sie, S.-S., additional, Chen, C.-Y., additional, Kuan, T.-C., additional, Lin, C. S., additional, Ismailoglu, Z., additional, Guven, M., additional, Yakici, A., additional, Ata, Y., additional, Ozcan, S., additional, Yildirim, E., additional, Ongen, Z., additional, Miroshnikova, V., additional, Demina, E., additional, Rodygina, T., additional, Kurjanov, P., additional, Denisenko, A., additional, Schwarzman, A., additional, Rubanenko, A., additional, Shchukin, Y., additional, Germanov, A., additional, Goldbergova, M., additional, Parenica, J., additional, Lipkova, J., additional, Pavek, N., additional, Kala, P., additional, Poloczek, M., additional, Vasku, A., additional, Parenicova, I., additional, Spinar, J., additional, Gambacciani, C., additional, Chiavacci, E., additional, Evangelista, M., additional, Vesentini, N., additional, Kusmic, C., additional, Pitto, L., additional, Chernova, A., additional, Nikulina, S. U. Y., additional, Arvanitis, D. A., additional, Mourouzis, I., additional, Pantos, C., additional, Kranias, E. G., additional, Cokkinos, D. V., additional, Sanoudou, D., additional, Vladimirskaya, T. E., additional, Shved, I. A., additional, Kryvorot, S. G., additional, Schirmer, I. M., additional, Appukuttan, A., additional, Pott, L., additional, Jaquet, K., additional, Ladilov, Y., additional, Archer, C. R., additional, Bootman, M. D., additional, Roderick, H. L., additional, Fusco, A., additional, Sorriento, D., additional, Santulli, G., additional, Trimarco, B., additional, Iaccarino, G., additional, Hagenmueller, M., additional, Riffel, J., additional, Bernhold, E., additional, Katus, H. A., additional, Hardt, S. E., additional, Maqsood, A., additional, Zi, M., additional, Prehar, S., additional, Neyses, L., additional, Ray, S., additional, Oceandy, D., additional, Khatami, N., additional, Wadowski, P., additional, Wagh, V., additional, Hescheler, J., additional, Sachinidis, A., additional, Mohl, W., additional, Chaudhry, B., additional, Burns, D., additional, Henderson, D. J., additional, Bax, N. A. M., additional, Van Marion, M. H., additional, Shah, B., additional, Goumans, M. J., additional, Bouten, C. V. C., additional, Van Der Schaft, D. W. J., additional, Van Oorschot, A. A. M., additional, Maas, S., additional, Braun, J., additional, Van Tuyn, J., additional, De Vries, A. A. F., additional, Gittenberger-De Groot, A. C., additional, Bageghni, S., additional, Drinkhill, M. J., additional, Batten, T. F. C., additional, Ainscough, J. F. X., additional, Onate, B., additional, Vilahur, G., additional, Ferrer-Lorente, R., additional, Ybarra, J., additional, Diez-Caballero, A., additional, Ballesta-Lopez, C., additional, Moscatiello, F., additional, Herrero, J., additional, Badimon, L., additional, Martin-Rendon, E., additional, Clifford, D. M., additional, Fisher, S. A., additional, Brusnkill, S. J., additional, Doree, C., additional, Mathur, A., additional, Clarke, M., additional, Watt, S. M., additional, Hernandez-Vera, R., additional, Kavanagh, D., additional, Yemm, A. I., additional, Frampton, J., additional, Kalia, N., additional, Terajima, Y., additional, Shimizu, T., additional, Tsuruyama, S., additional, Ishii, H., additional, Sekine, H., additional, Hagiwara, N., additional, Okano, T., additional, Vrijsen, K. R., additional, Chamuleau, S. A. J., additional, Sluijter, J. P. G., additional, Doevendans, P. F. M., additional, Madonna, R., additional, Delli Pizzi, S., additional, Di Donato, L., additional, Mariotti, A., additional, Di Carlo, L., additional, D'ugo, E., additional, Teberino, M. A., additional, Merla, A., additional, T, A., additional, De Caterina, R., additional, Kolker, L., additional, Ali, N. N., additional, Maclellan, K., additional, Moore, M., additional, Wheeler, J., additional, Harding, S. E., additional, Fleck, R. A., additional, Rowlinson, J. M., additional, Kraenkel, N., additional, Ascione, R., additional, Madeddu, P., additional, O'sullivan, J. F., additional, Leblond, A. L., additional, Kelly, G., additional, Kumar, A. H. S., additional, Metharom, P., additional, Buneker, C. K., additional, Alizadeh-Vikali, N., additional, Hynes, B. G., additional, O'connor, R., additional, Caplice, N. M., additional, Noseda, M., additional, De Smith, A. J., additional, Leja, T., additional, Rao, P. H., additional, Al-Beidh, F., additional, Abreu Pavia, M. S., additional, Blakemore, A. I., additional, Schneider, M. D., additional, Stathopoulou, K., additional, Cuello, F., additional, Ehler, E., additional, Haworth, R. S., additional, Avkiran, M., additional, Morawietz, H., additional, Eickholt, C., additional, Langbein, H., additional, Brux, M., additional, Goettsch, C., additional, Goettsch, W., additional, Arsov, A., additional, Brunssen, C., additional, Mazilu, L., additional, Parepa, I. R., additional, Suceveanu, A. I., additional, Suceveanu, A. P., additional, De Man, F. S., additional, Guignabert, C., additional, Tu, L., additional, Handoko, M. L., additional, Schalij, I., additional, Fadel, E., additional, Postmus, P. E., additional, Vonk-Noordegraaf, A., additional, Humbert, M., additional, Eddahibi, S., additional, Del Giudice, C., additional, Anastasio, A., additional, Fazal, L., additional, Azibani, F., additional, Bihry, N., additional, Merval, R., additional, Polidano, E., additional, Samuel, J.-L., additional, Delcayre, C., additional, Zhang, Y., additional, Mi, Y. M., additional, Ren, L. L., additional, Cheng, Y. P., additional, Guo, R., additional, Liu, Y., additional, Jiang, Y. N., additional, Kokkinos, A. D., additional, Tretjakovs, P., additional, Jurka, A., additional, Bormane, I., additional, Mikelsone, I., additional, Reihmane, D., additional, Elksne, K., additional, Krievina, G., additional, Verbovenko, J., additional, Bahs, G., additional, Lopez-Andres, N., additional, Rousseau, A., additional, Calvier, L., additional, Akhtar, R., additional, Labat, C., additional, Cruickshank, K., additional, Diez, J., additional, Zannad, F., additional, Lacolley, P., additional, Rossignol, P., additional, Hamesch, K., additional, Subramanian, P., additional, Li, X., additional, Thiemann, A., additional, Heyll, K., additional, Dembowsky, K., additional, Chevalier, E., additional, Weber, C., additional, Schober, A., additional, Yang, L., additional, Kim, G., additional, Gardner, B., additional, Earley, J., additional, Hofmann-Bowman, M., additional, Cheng, C.-F., additional, Lian, W.-S., additional, Lin, H., additional, Jinjolia, N. J., additional, Abuladze, G. A., additional, Tvalchrelidze, S. H. T., additional, Khamnagadaev, I., additional, Shkolnikova, M., additional, Kokov, L., additional, Miklashevich, I., additional, Drozdov, I., additional, Ilyich, I., additional, Bingen, B. O., additional, Askar, S. F. A., additional, Ypey, D. L., additional, Van Der Laarse, A., additional, Schalij, M. J., additional, Pijnappels, D. A., additional, Roney, C. H., additional, Ng, F. S., additional, Chowdhury, R. A., additional, Chang, E. T. Y., additional, Patel, P. M., additional, Lyon, A. R., additional, Siggers, J. H., additional, Peters, N. S., additional, Obergrussberger, A., additional, Stoelzle, S., additional, Bruggemann, A., additional, Haarmann, C., additional, George, M., additional, Fertig, N., additional, Moreira, D., additional, Souza, A., additional, Valente, P., additional, Kornej, J., additional, Reihardt, C., additional, Kosiuk, J., additional, Arya, A., additional, Hindricks, G., additional, Adams, V., additional, Husser, D., additional, Bollmann, A., additional, Camelliti, P., additional, Dudhia, J., additional, Dias, P., additional, Cartledge, J., additional, Connolly, D. J., additional, Nobles, M., additional, Sebastian, S., additional, Tinker, A., additional, Opel, A., additional, Daimi, H., additional, Haj Khelil, A., additional, Be Chibani, J., additional, Barana, A., additional, Amoros, I., additional, Gonzalez De La Fuente, M., additional, Caballero, R., additional, Aranega, A., additional, Kelly, A., additional, Bernus, O., additional, Kemi, O. J., additional, Myles, R. C., additional, Ghouri, I. A., additional, Burton, F. L., additional, Smith, G. L., additional, Del Lungo, M., additional, Sartiani, L., additional, Spinelli, V., additional, Baruscotti, M., additional, Difrancesco, D., additional, Mugelli, A., additional, Cerbai, E., additional, Thomas, A. M., additional, Aziz, Q., additional, Khambra, T., additional, Addlestone, J. M. A., additional, Cartwright, E. J., additional, Wilkinson, R., additional, Song, W., additional, Marston, S., additional, Jacquet, A., additional, Mougenot, N. M., additional, Lipskaia, A. J., additional, Paalberends, E. R., additional, Stam, K., additional, Van Dijk, S. J., additional, Van Slegtenhorst, M., additional, Dos Remedios, C., additional, Ten Cate, F. J., additional, Michels, M., additional, Niessen, H. W. M., additional, Stienen, G. J. M., additional, Van Der Velden, J., additional, Read, M. I., additional, Andreianova, A. A., additional, Harrison, J. C., additional, Goulton, C. S., additional, Kerr, D. S., additional, Sammut, I. A., additional, Wallner, M., additional, Von Lewinski, D., additional, Kindsvater, D., additional, Saes, M., additional, Morano, I., additional, Muegge, A., additional, Buyandelger, B., additional, Kostin, S., additional, Gunkel, S., additional, Vouffo, J., additional, Ng, K., additional, Chen, J., additional, Eilers, M., additional, Isaacson, R., additional, Milting, H., additional, Knoell, R., additional, Cattin, M.-E., additional, Crocini, C., additional, Schlossarek, S., additional, Maron, S., additional, Hansen, A., additional, Eschenhagen, T., additional, Carrier, L., additional, Bonne, G., additional, Coppini, R., additional, Ferrantini, C., additional, Olivotto, I., additional, Belardinelli, L., additional, Poggesi, C., additional, Leung, M. C., additional, Messer, A. E., additional, Copeland, O., additional, Marston, S. B., additional, Mills, A. M., additional, Collins, T., additional, O'gara, P., additional, Thum, T., additional, Regalla, K., additional, Macleod, K. T., additional, Prodromakis, T., additional, Chaudhry, U., additional, Darzi, A., additional, Yacoub, M. H., additional, Athanasiou, T., additional, Bogdanova, A., additional, Makhro, A., additional, Hoydal, M., additional, Stolen, T. O., additional, Johnssen, A. B., additional, Alves, M., additional, Catalucci, D., additional, Condorelli, G., additional, Koch, L. G., additional, Britton, S. L., additional, Wisloff, U., additional, Bito, V., additional, Claus, P., additional, Vermeulen, K., additional, Huysmans, C., additional, Ventura-Clapier, R., additional, Sipido, K. R., additional, Seliuk, M. N., additional, Burlaka, A. P., additional, Sidorik, E. P., additional, Khaitovych, N. V., additional, Kozachok, M. M., additional, Potaskalova, V. S., additional, Driesen, R. B., additional, Galan, D. T., additional, De Paulis, D., additional, Arnoux, T., additional, Schaller, S., additional, Pruss, R. M., additional, Poitz, D. M., additional, Augstein, A., additional, Braun-Dullaeus, R. C., additional, Schmeisser, A., additional, Strasser, R. H., additional, Micova, P., additional, Balkova, P., additional, Hlavackova, M., additional, Zurmanova, J., additional, Kasparova, D., additional, Kolar, F., additional, Neckar, J., additional, Novak, F., additional, Novakova, O., additional, Pollard, S., additional, Babba, M., additional, Hussain, A., additional, James, R., additional, Maddock, H., additional, Alshehri, A. S., additional, Baxter, G. F., additional, Dietel, B., additional, Altendorf, R., additional, Daniel, W. G., additional, Kollmar, R., additional, Garlichs, C. D., additional, Sirohi, R., additional, Roberts, N., additional, Lawrence, D., additional, Sheikh, A., additional, Kolvekar, S., additional, Yap, J., additional, Arend, M., additional, Walkinshaw, G., additional, Hausenloy, D. J., additional, Yellon, D. M., additional, Posa, A., additional, Szabo, R., additional, Szalai, Z., additional, Szablics, P., additional, Berko, M. A., additional, Orban, K., additional, Murlasits, Z. S., additional, Balogh, L., additional, Varga, C., additional, Ku, H. C., additional, Su, M. J., additional, Chreih, R.-M., additional, Ginghina, C., additional, Deleanu, D., additional, Ferreira, A. L. B. J., additional, Belal, A., additional, Ali, M. A., additional, Fan, X., additional, Holt, A., additional, Campbell, R., additional, Schulz, R., additional, Bonanad, C., additional, Bodi, V., additional, Sanchis, J., additional, Morales, J. M., additional, Marrachelli, V., additional, Nunez, J., additional, Forteza, M. J., additional, Chaustre, F., additional, Gomez, C., additional, Chorro, F. J., additional, Csont, T., additional, Fekete, V., additional, Murlasits, Z., additional, Aypar, E., additional, Bencsik, P., additional, Sarkozy, M., additional, Varga, Z. V., additional, Ferdinandy, P., additional, Duerr, G. D., additional, Zoerlein, M., additional, Dewald, D., additional, Mesenholl, B., additional, Schneider, P., additional, Ghanem, A., additional, Rittling, S., additional, Welz, A., additional, Dewald, O., additional, Becker, E., additional, Peigney, C., additional, Bouleti, C., additional, Galaup, A., additional, Monnot, C., additional, Ghaleh, B., additional, Germain, S., additional, Timmermans, A., additional, Ginion, A., additional, De Meester, C., additional, Sakamoto, K., additional, Vanoverschelde, J.-L., additional, Horman, S., additional, Beauloye, C., additional, Bertrand, L., additional, Maroz-Vadalazhskaya, N., additional, Drozd, E., additional, Kukharenko, L., additional, Russkich, I., additional, Krachak, D., additional, Seljun, Y., additional, Ostrovski, Y., additional, Martin, A.-C., additional, Le Bonniec, B., additional, Lecompte, T., additional, Dizier, B., additional, Emmerich, J., additional, Fischer, A.-M., additional, Samama, C.-M., additional, Godier, A., additional, Mogensen, S., additional, Furchtbauer, E. M., additional, Aalkjaer, C., additional, Choong, W. L., additional, Jovanovic, A., additional, Khan, F., additional, Daniel, J. M., additional, Dutzmann, J. M., additional, Widmer-Teske, R., additional, Guenduez, D., additional, Sedding, D., additional, Castro, M. M., additional, Cena, J. J. C., additional, Cho, W. J. C., additional, Goobie, G. G., additional, Walsh, M. P. W., additional, Schulz, R. S., additional, Dutzmann, J., additional, Preissner, K. T., additional, Sones, W., additional, Kotlikoff, M., additional, Serizawa, K., additional, Yogo, K., additional, Aizawa, K., additional, Hirata, M., additional, Tashiro, Y., additional, Ishizuka, N., additional, Varela, A., additional, Katsiboulas, M., additional, Tousoulis, D., additional, Papaioannou, T. G., additional, Vaina, S., additional, Davos, C. H., additional, Piperi, C., additional, Stefanadis, C., additional, Basdra, E. K., additional, Papavassiliou, A. G., additional, Hermenegildo, C., additional, Lazaro-Franco, M., additional, Sobrino, A., additional, Bueno-Beti, C., additional, Martinez-Gil, N., additional, Walther, T., additional, Peiro, C., additional, Sanchez-Ferrer, C. F., additional, Novella, S., additional, Ciccarelli, M., additional, Franco, A., additional, Dorn, G. W., additional, Cseplo, P., additional, Torok, O., additional, Springo, Z. S., additional, Vamos, Z., additional, Kosa, D., additional, Hamar, J., additional, Koller, A., additional, Bubb, K. J., additional, Ahluwalia, A., additional, Stepien, E. L., additional, Gruca, A., additional, Grzybowska, J., additional, Goralska, J., additional, Dembinska-Kiec, A., additional, Stolinski, J., additional, Partyka, L., additional, Zhang, H., additional, Sweeney, D., additional, Thomas, G. N., additional, Fish, P. V., additional, Taggart, D. P., additional, Cioffi, S., additional, Bilio, M., additional, Martucciello, S., additional, Illingworth, E., additional, Caporali, A., additional, Shantikumar, S., additional, Marchetti, M., additional, Martelli, F., additional, Emanueli, C., additional, Meloni, M., additional, Al Haj Zen, A., additional, Sala-Newby, G., additional, Del Turco, S., additional, Saponaro, C., additional, Dario, B., additional, Sartini, S., additional, Menciassi, A., additional, Dario, P., additional, La Motta, C., additional, Basta, G., additional, Santiemma, V., additional, Bertone, C., additional, Rossi, F., additional, Michelon, E., additional, Bianco, M. J., additional, Castelli, A., additional, Shin, D. I., additional, Seung, K. B., additional, Seo, S. M., additional, Park, H. J., additional, Kim, P. J., additional, Baek, S. H., additional, Choi, Y. S., additional, Her, S. H., additional, Kim, D. B., additional, Lee, J. M., additional, Park, C. S., additional, Rocchiccioli, S., additional, Cecchettini, A., additional, Pelosi, G., additional, Citti, L., additional, Parodi, O., additional, Trivella, M. G., additional, Michel-Monigadon, D., additional, Burger, F., additional, Dunoyer-Geindre, S., additional, Pelli, G., additional, Cravatt, B., additional, Steffens, S., additional, Didangelos, A., additional, Mayr, U., additional, Yin, X., additional, Stegemann, C., additional, Shalhoub, J., additional, Davies, A. H., additional, Monaco, C., additional, Mayr, M., additional, Lypovetska, S., additional, Grytsenko, S., additional, Njerve, I. U., additional, Pettersen, A. A., additional, Opstad, T. B., additional, Bratseth, V., additional, Arnesen, H., additional, Seljeflot, I., additional, Dumitriu, I. E., additional, Baruah, P., additional, Antunes, R. F., additional, Kaski, J. C., additional, Trapero, I., additional, Benet, I., additional, Alguero, C., additional, Chaustre, F. J., additional, Mangold, A., additional, Puthenkalam, S., additional, Distelmaier, K., additional, Adlbrecht, C., additional, Lang, I. M., additional, Koizumi, T., additional, Inoue, I., additional, Komiyama, N., additional, Nishimura, S., additional, Korneeva, O. N., additional, Drapkina, O. M., additional, Fornai, L., additional, Angelini, A., additional, Kiss, A., additional, Giskes, F., additional, Eijkel, G., additional, Fedrigo, M., additional, Valente, M. L., additional, Thiene, G., additional, Heeren, R. M. A., additional, Padro, T., additional, Casani, L., additional, Suades, R., additional, Bertoni, B., additional, Carminati, R., additional, Carlini, V., additional, Pettinari, L., additional, Martinelli, C., additional, Gagliano, N., additional, Noppe, G., additional, Buchlin, P., additional, Marquet, N., additional, Baeyens, N., additional, Morel, N., additional, Baysa, A., additional, Sagave, J., additional, Dahl, C. P., additional, Gullestad, L., additional, Carpi, A., additional, Di Lisa, F., additional, Giorgio, M., additional, Vaage, J., additional, Valen, G., additional, Vafiadaki, E., additional, Papalouka, V., additional, Terzis, G., additional, Spengos, K., additional, Manta, P., additional, Gales, C., additional, Genet, G., additional, Dague, E., additional, Cazorla, O., additional, Payre, B., additional, Mias, C., additional, Ouille, A., additional, Lacampagne, A., additional, Pathak, A., additional, Senard, J. M., additional, Abonnenc, M., additional, Da Costa Martins, P., additional, Srivastava, S., additional, Gautel, M., additional, De Windt, L., additional, Comelli, L., additional, Lande, C., additional, Ucciferri, N., additional, Ikonen, L., additional, Vuorenpaa, H., additional, Kujala, K., additional, Sarkanen, J.-R., additional, Heinonen, T., additional, Ylikomi, T., additional, Aalto-Setala, K., additional, Capros, H., additional, Sprincean, N., additional, Usurelu, N., additional, Egorov, V., additional, Stratu, N., additional, Matchkov, V., additional, Bouzinova, E., additional, Moeller-Nielsen, N., additional, Wiborg, O., additional, Gutierrez, P. S., additional, Aparecida-Silva, R., additional, Borges, L. F., additional, Moreira, L. F. P., additional, Dias, R. R., additional, Kalil, J., additional, Stolf, N. A. G., additional, Zhou, W., additional, Suntharalingam, K., additional, Brand, N., additional, Vilar Compte, R., additional, Ying, L., additional, Bicknell, K., additional, Dannoura, A., additional, Dash, P., additional, Brooks, G., additional, Tsimafeyeu, I., additional, Tishova, Y., additional, Wynn, N., additional, Oyeyipo, I. P., additional, Olatunji, L. A., additional, Maegdefessel, L., additional, Azuma, J., additional, Toh, R., additional, Raaz, U., additional, Merk, D. R., additional, Deng, A., additional, Spin, J. M., additional, Tsao, P. S., additional, Tedeschi, L., additional, Taranta, M., additional, Naldi, I., additional, Grimaldi, S., additional, Cinti, C., additional, Bousquenaud, M., additional, Maskali, F., additional, Poussier, S., additional, Marie, P. Y., additional, Boutley, H., additional, Karcher, G., additional, Wagner, D. R., additional, Devaux, Y., additional, Torre, I., additional, Psilodimitrakopoulos, S., additional, Iruretagoiena, I., additional, Gonzalez-Tendero, A., additional, Artigas, D., additional, Loza-Alvarez, P., additional, Gratacos, E., additional, Amat-Roldan, I., additional, Murray, L., additional, Carberry, D. M., additional, Dunton, P., additional, Miles, M. J., additional, Suleiman, M.-S., additional, Kanesalingam, K., additional, Taylor, R., additional, Mc Collum, C. N., additional, Parniczky, A., additional, Solymar, M., additional, Porpaczy, A., additional, Miseta, A., additional, Lenkey, Z. S., additional, Szabados, S., additional, Cziraki, A., additional, Garai, J., additional, Myloslavska, I., additional, Menazza, S. M., additional, Canton, M. C., additional, Di Lisa, F. D. L., additional, Oliveira, S. H. V., additional, Morais, C. A. S., additional, Miranda, M. R., additional, Oliveira, T. T., additional, Lamego, M. R. A., additional, Lima, L. M., additional, Goncharova, N. S., additional, Naymushin, A. V., additional, Kazimli, A. V., additional, Moiseeva, O. M., additional, Carvalho, M. G., additional, Sabino, A. P., additional, Mota, A. P. L., additional, Sousa, M. O., additional, Niessner, A., additional, Richter, B., additional, Hohensinner, P. J., additional, Rychli, K., additional, Zorn, G., additional, Berger, R., additional, Moertl, D., additional, Pacher, R., additional, Wojta, J., additional, Huelsmann, M., additional, Kukharchik, G., additional, Nesterova, N., additional, Pavlova, A., additional, Gaykovaya, L., additional, Krapivka, N., additional, Konstantinova, I., additional, Sichinava, L., additional, Prapa, S., additional, Mccarthy, K. P., additional, Kilner, P. J., additional, Xu, X. Y., additional, Johnson, M. R., additional, Ho, S. Y., additional, Gatzoulis, M. A., additional, Stoupel, E. G., additional, Garcia, R., additional, Merino, D., additional, Montalvo, C., additional, Hurle, M. A., additional, Nistal, J. F., additional, Villar, A. V., additional, Perez-Moreno, A., additional, Gilabert, R., additional, and Ros, E., additional
- Published
- 2012
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19. Foliar 13C and 18O reveal differential physiological responses of canopy foliage to pre-planting weed control in a young spotted gum (Corymbia citriodora subsp. Variegata) plantation
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Huang, Z., primary, Xu, Z., additional, Blumfield, T. J., additional, and Bubb, K., additional
- Published
- 2008
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20. Variations in relative stomatal and biochemical limitations to photosynthesis in a young blackbutt (Eucalyptus pilularis) plantation subjected to different weed control regimes
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Huang, Z., primary, Xu, Z., additional, Blumfield, T. J., additional, and Bubb, K., additional
- Published
- 2008
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- View/download PDF
21. P1-23 The effect of early life vitamin D insufficiency on development of the heart in 4 week old rat offspring
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Gezmish, O., primary, Tare, M., additional, Parkington, H.C., additional, Bubb, K., additional, and Black, M.J., additional
- Published
- 2007
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- View/download PDF
22. Effect of Statins on Serial Coronary Atheroma Burdens: Pooled Analysis from Six Randomised Clinical Trials.
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Hamilton, J., Fujino, M., Bubb, K., and Nicholls, S.
- Subjects
- *
ATHEROSCLEROTIC plaque , *CLINICAL trials , *STATINS (Cardiovascular agents) - Published
- 2024
- Full Text
- View/download PDF
23. Scan of Human Genome Reveals No New Loci Under Ancient Balancing Selection
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Bubb, K L, primary, Bovee, D, additional, Buckley, D, additional, Haugen, E, additional, Kibukawa, M, additional, Paddock, M, additional, Palmieri, A, additional, Subramanian, S, additional, Zhou, Y, additional, Kaul, R, additional, Green, P, additional, and Olson, M V, additional
- Published
- 2006
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- View/download PDF
24. Sediment and nutrient losses from exoticPinusplantation management operations under simulated rainfall
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Forsyth, A. R., primary, Bubb, K. A., additional, and Cox, M. E., additional
- Published
- 2006
- Full Text
- View/download PDF
25. Hypervariability, suppressed recombination and the genetics of individuality
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Olson, M. V., primary, Kas, A., additional, Bubb, K., additional, Qui, R., additional, Smith, E. E., additional, Raymond, C. K., additional, and Kaul, R., additional
- Published
- 2004
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- View/download PDF
26. Efficacy of atrazine and simazine applications over harvest residue in Queensland's subtropical softwood plantations
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Bubb, K. A., primary, Frayne, P. F., additional, Wittmer, T. R., additional, and Grimmett, J. L., additional
- Published
- 2003
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- View/download PDF
27. Impacts on stream and groundwater quality during the inter-rotation phase of aPinusplantation in the coastal lowlands of south-east Queensland
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Bubb, K. A., primary, Frayne, P. F., additional, and Wittmer, T. R., additional
- Published
- 2002
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- View/download PDF
28. Simazine concentrations in soil, groundwater and stream water following application toPinusplantations in the coastal lowlands of south-east Queensland
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Bubb, K. A., primary
- Published
- 2001
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- View/download PDF
29. The centromeric end of HLA class I: MCD maps of yac derived cosmids and sequence analysis of 250 KB of genomic DNA
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Guillaudeux, T, primary, Janer, M, additional, Bubb, K, additional, Wong, GKS, additional, Olson, MV, additional, Spies, T, additional, and Geraphty, DE, additional
- Published
- 1996
- Full Text
- View/download PDF
30. The role of sonography in breast conservation therapy using breast brachytherapy.
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Bubb K and Hooper C
- Abstract
Sonography of the breast is a rapidly expanding specialty area. It is routinely used in conjunction with mammography. The role of sonography in breast examinations primarily consists of a targeted study focusing on a specific abnormality seen on a mammogram. Sonography is also used to evaluate palpable breast masses, dense breast tissue, and breast implants. Sonographic guidance is often used in interventional procedures such as core needle biopsies, fine needle aspirations, needle wire localizations, and handheld mammotomes. Recently, the role of sonography in breast care has expanded. Breast brachy-therapy (internal radiation therapy) is a type of radiotherapy that can be used in breast conservation therapy (BCT). This article is limited to the role of sonography in BCT breast brachy-therapy. The surgical technique, radiation do-simetry, computed tomography, and mammo-graphic roles are not discussed in detail. [ABSTRACT FROM AUTHOR]
- Published
- 2003
31. Acetate Lowers Human Blood Pressure Whether Administered Directly or Produced Indirectly in the Colon.
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Xing, M., Bonaddio, J., Bubb, K., Nicholls, S., Kemp-Harper, B., and White, A.
- Subjects
- *
BLOOD pressure , *COLON (Anatomy) , *ACETATES , *HUMAN beings - Published
- 2024
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- View/download PDF
32. Single cell RNA sequencing identifies mitochondrial respiration as a key factor contributing to extracellular matrix integrity
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Bubb, K, Holzer, T, Nolte, J L, Krüger, M, Wilson, R, Schlötzer-Schrehardt, U, Brinckmann, J, Altmüller, J, Aszodi, A, Fleischhauer, L, Clausen-Schaumann, H, Probst, K, and Brachvogel, B
- Published
- 2021
- Full Text
- View/download PDF
33. Improved Cardiac Function After Sleeve Gastrectomy is Associated With Elevated Brown Fat Activity.
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Goubar, T., Salimova, E., Rushworth, L., Bubb, K., and Stefanidis, A.
- Subjects
- *
BROWN adipose tissue , *SLEEVE gastrectomy - Published
- 2024
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- View/download PDF
34. Pulmonary Arterial Hypertension and Right Ventricular Remodelling are Attenuated After Neurokinin 1 Receptor Inhibition.
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Hetherington, K., Chuglani, H., Thomas, J., Widapradja, A., Levick, S., Kemp-Harper, B., Nicholls, S., and Bubb, K.
- Subjects
- *
SUBSTANCE P receptors , *PULMONARY arterial hypertension , *VENTRICULAR remodeling - Published
- 2024
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- View/download PDF
35. Activation of the C-Type Natriuretic Peptide Pathway Offers a Novel Therapeutic Target for Gestational Hypertension.
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Barsha, G., Hong, Q., Nelson, J., Walton, S., Hetherington, K., Thomas, J., Nicholls, S., Hobbs, A., and Bubb, K.
- Subjects
- *
PEPTIDES , *HYPERTENSION , *ANGIOTENSIN I , *BRAIN natriuretic factor - Published
- 2024
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- View/download PDF
36. Peripheral Vascular Inflammation is Increased in Myeloid-Restricted Tet2-Deficient Mice.
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Thomas, J., Hetherington, K., Nicholls, S., and Bubb, K.
- Subjects
- *
INFLAMMATION , *MICE - Published
- 2024
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- View/download PDF
37. O342 - The centromeric end of HLA class I: MCD maps of yac derived cosmids and sequence analysis of 250 KB of genomic DNA
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Guillaudeux, T, Janer, M, Bubb, K, Wong, GKS, Olson, MV, Spies, T, and Geraphty, DE
- Published
- 1996
- Full Text
- View/download PDF
38. LRPPRC and SLIRP synergize to maintain sufficient and orderly mammalian mitochondrial translation.
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Rubalcava-Gracia D, Bubb K, Levander F, Burr SP, August AV, Chinnery PF, Koolmeister C, and Larsson NG
- Abstract
In mammals, the leucine-rich pentatricopeptide repeat protein (LRPPRC) and the stem-loop interacting RNA-binding protein (SLIRP) form a complex in the mitochondrial matrix that is required throughout the life cycle of most mitochondrial mRNAs. Although pathogenic mutations in the LRPPRC and SLIRP genes cause devastating human mitochondrial diseases, the in vivo function of the corresponding proteins is incompletely understood. We show here that loss of SLIRP in mice causes a decrease of complex I levels whereas other OXPHOS complexes are unaffected. We generated knock-in mice to study the in vivo interdependency of SLIRP and LRPPRC by mutating specific amino acids necessary for protein complex formation. When protein complex formation is disrupted, LRPPRC is partially degraded and SLIRP disappears. Livers from Lrpprc knock-in mice had impaired mitochondrial translation except for a marked increase in the synthesis of ATP8. Furthermore, the introduction of a heteroplasmic pathogenic mtDNA mutation (m.C5024T of the tRNAAla gene) into Slirp knockout mice causes an additive effect on mitochondrial translation leading to embryonic lethality and reduced growth of mouse embryonic fibroblasts. To summarize, we report that the LRPPRC/SLIRP protein complex is critical for maintaining normal complex I levels and that it also coordinates mitochondrial translation in a tissue-specific manner., (© The Author(s) 2024. Published by Oxford University Press on behalf of Nucleic Acids Research.)
- Published
- 2024
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- View/download PDF
39. Arabidopsis and maize terminator strength is determined by GC content, polyadenylation motifs and cleavage probability.
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Gorjifard S, Jores T, Tonnies J, Mueth NA, Bubb K, Wrightsman T, Buckler ES, Fields S, Cuperus JT, and Queitsch C
- Subjects
- Gene Expression Regulation, Plant, Terminator Regions, Genetic genetics, Nicotiana genetics, Nicotiana metabolism, RNA, Messenger genetics, RNA, Messenger metabolism, Zea mays genetics, Zea mays metabolism, Arabidopsis genetics, Arabidopsis metabolism, Polyadenylation
- Abstract
The 3' end of a gene, often called a terminator, modulates mRNA stability, localization, translation, and polyadenylation. Here, we adapted Plant STARR-seq, a massively parallel reporter assay, to measure the activity of over 50,000 terminators from the plants Arabidopsis thaliana and Zea mays. We characterize thousands of plant terminators, including many that outperform bacterial terminators commonly used in plants. Terminator activity is species-specific, differing in tobacco leaf and maize protoplast assays. While recapitulating known biology, our results reveal the relative contributions of polyadenylation motifs to terminator strength. We built a computational model to predict terminator strength and used it to conduct in silico evolution that generated optimized synthetic terminators. Additionally, we discover alternative polyadenylation sites across tens of thousands of terminators; however, the strongest terminators tend to have a dominant cleavage site. Our results establish features of plant terminator function and identify strong naturally occurring and synthetic terminators., (© 2024. The Author(s).)
- Published
- 2024
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- View/download PDF
40. Optimization of ATAC-seq in wheat seedling roots using INTACT-isolated nuclei.
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Debernardi JM, Burguener G, Bubb K, Liu Q, Queitsch C, and Dubcovsky J
- Subjects
- Triticum genetics, Reproducibility of Results, Tetraploidy, Chromatin genetics, Sequence Analysis, DNA methods, High-Throughput Nucleotide Sequencing methods, Chromatin Immunoprecipitation Sequencing, Seedlings genetics
- Abstract
Background: The genetic information contained in the genome of an organism is organized in genes and regulatory elements that control gene expression. The genomes of multiple plants species have already been sequenced and the gene repertory have been annotated, however, cis-regulatory elements remain less characterized, limiting our understanding of genome functionality. These elements act as open platforms for recruiting both positive- and negative-acting transcription factors, and as such, chromatin accessibility is an important signature for their identification., Results: In this work we developed a transgenic INTACT [isolation of nuclei tagged in specific cell types] system in tetraploid wheat for nuclei purifications. Then, we combined the INTACT system together with the assay for transposase-accessible chromatin with sequencing [ATAC-seq] to identify open chromatin regions in wheat root tip samples. Our ATAC-seq results showed a large enrichment of open chromatin regions in intergenic and promoter regions, which is expected for regulatory elements and that is similar to ATAC-seq results obtained in other plant species. In addition, root ATAC-seq peaks showed a significant overlap with a previously published ATAC-seq data from wheat leaf protoplast, indicating a high reproducibility between the two experiments and a large overlap between open chromatin regions in root and leaf tissues. Importantly, we observed overlap between ATAC-seq peaks and cis-regulatory elements that have been functionally validated in wheat, and a good correlation between normalized accessibility and gene expression levels., Conclusions: We have developed and validated an INTACT system in tetraploid wheat that allows rapid and high-quality nuclei purification from root tips. Those nuclei were successfully used to performed ATAC-seq experiments that revealed open chromatin regions in the wheat genome that will be useful to identify cis-regulatory elements. The INTACT system presented here will facilitate the development of ATAC-seq datasets in other tissues, growth stages, and under different growing conditions to generate a more complete landscape of the accessible DNA regions in the wheat genome., (© 2023. The Author(s).)
- Published
- 2023
- Full Text
- View/download PDF
41. Impact of lipid lowering on coronary atherosclerosis moving from the lumen to the artery wall.
- Author
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Di Giovanni G, Kataoka Y, Bubb K, Nelson AJ, and Nicholls SJ
- Subjects
- Humans, Cholesterol, LDL, Arteries, Coronary Artery Disease diagnostic imaging, Coronary Artery Disease drug therapy, Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use, Plaque, Atherosclerotic drug therapy
- Abstract
Randomized clinical trials have demonstrated that increasingly intensive lowering of low-density lipoprotein cholesterol (LDL-C) reduces the rate of cardiovascular events in the primary and secondary prevention setting. Integration of serial coronary imaging within clinical trials has enabled evaluation of medical therapies on the natural history of coronary disease. These studies have extended from early investigation of coronary obstruction with angiography to more contemporary evaluation of plaque burden and composition with imaging modalities that directly visualize the artery wall. The findings of these trials have demonstrated that intensive lipid lowering promotes plaque regression and stabilization. The lessons of this body of research provide a biological rationale underscoring the ability of intensive lipid lowering to reduce cardiovascular risk and have the potential to promote greater uptake in clinical practice., Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Y.K. has received research support from Kowa, and speaker honoraria from Abbott Vascular, Amgen, CSL Behring, Daiichi Sankyo, Kowa, Nipro, and Takeda. S.J.N. has received research support from AstraZeneca, Amgen, Anthera, CSL Behring, Cerenis, Eli Lilly, Esperion, Resverlogix, Novartis, InfraReDx and Sanofi-Regeneron and is a consultant for Amgen, Akcea, AstraZeneca, Boehringer Ingelheim, CSL Behring, Eli Lilly, Esperion, Kowa, Merck, Takeda, Pfizer, Sanofi-Regeneron and Novo Nordisk. All other authors have no relationships to disclose., (Copyright © 2023 Elsevier B.V. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF
42. 20-hydroxyeicosatetraenoic acid (20-HETE) is a pivotal endogenous ligand for TRPV1-mediated neurogenic inflammation in the skin.
- Author
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Hamers A, Primus CP, Whitear C, Kumar NA, Masucci M, Montalvo Moreira SA, Rathod K, Chen J, Bubb K, Colas R, Khambata RS, Dalli J, and Ahluwalia A
- Subjects
- Animals, Arachidonic Acid chemistry, Arachidonic Acid metabolism, Blister, Cantharidin, Edema, Humans, Ligands, Lipopolysaccharides, Mice, Hydroxyeicosatetraenoic Acids metabolism, Hydroxyeicosatetraenoic Acids pharmacology, Neurogenic Inflammation chemically induced, Neurogenic Inflammation metabolism, TRPV Cation Channels metabolism
- Abstract
Background and Purpose: Transient receptor potential cation channel subfamily V member 1 (TRPV1) is localized to sensory C-fibres and its opening leads to membrane depolarization, resulting in neuropeptide release and neurogenic inflammation. However, the identity of the endogenous activator of TRPV1 in this setting is unknown. The arachidonic acid metabolites 12-hydroperoxyeicosatetraenoyl acid (12-HpETE) and 20-hydroxyeicosatetraenoic acid (20-HETE) have emerged as potential endogenous activators of TRPV1. However, whether these lipids underlie TRPV1-mediated neurogenic inflammation remains unknown., Experimental Approach: We analysed human cantharidin-induced blister samples and inflammatory responses in TRPV1 transgenic mice., Key Results: In a human cantharidin-blister model, the potent TRPV1 activators 20-HETE but not 12-HETE (stable metabolite of 12-HpETE) correlated with arachidonic acid levels. Similarly, in mice, levels of 20-HETE (but not 12-HETE) and arachidonic acid were strongly positively correlated within the inflammatory milieu. Furthermore, LPS-induced oedema formation and neutrophil recruitment were substantially and significantly attenuated by pharmacological block or genetic deletion of TRPV1 channels, inhibition of 20-HETE formation or SP receptor neurokinin 1 (NK
1 ) blockade. LPS treatment also increased cytochrome P450 ω-hydroxylase gene expression, the enzyme responsible for 20-HETE production., Conclusion and Implications: Taken together, our findings suggest that endogenously generated 20-HETE activates TRPV1 causing C-fibre activation and consequent oedema formation. These findings identify a novel pathway that may be useful in the therapeutics of diseases/conditions characterized by a prominent neurogenic inflammation, as in several skin diseases., (© 2021 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.)- Published
- 2022
- Full Text
- View/download PDF
43. An update on emerging drugs for the treatment of hypercholesterolemia.
- Author
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Nelson AJ, Bubb K, and Nicholls SJ
- Subjects
- Cholesterol, LDL, Humans, Hypolipidemic Agents therapeutic use, Anticholesteremic Agents pharmacology, Anticholesteremic Agents therapeutic use, Cardiovascular Diseases etiology, Cardiovascular Diseases prevention & control, Hydroxymethylglutaryl-CoA Reductase Inhibitors pharmacology, Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use, Hypercholesterolemia drug therapy, Pharmaceutical Preparations
- Abstract
Introduction: Elevated levels of low-density lipoprotein (LDL) cholesterol have been unequivocally demonstrated to play a causal role in atherosclerotic cardiovascular disease. The last thirty years have witnessed a generation of clinical trials that have demonstrated a reduction in cardiovascular risk with the use of increasing intensive lipid lowering regimens involving statin therapy in combination with other agents. However, many patients fail to achieve treatment mandated LDL cholesterol goals. This highlights the need to develop additional approaches to lower LDL cholesterol levels., Areas Covered: (i) Contemporary data highlighting the atherogenicity of LDL cholesterol and cardiovascular benefits of current lipid lowering therapies. (ii) Importance of statin intolerance and inability to achieve LDL cholesterol goals in driving ongoing cardiovascular risk. (iii) Emergence of new therapeutic agents designed to achieve more effective lowering of LDL cholesterol., Expert Opinion: Effective lowering of LDL cholesterol plays a critical role in approaches to the prevention of cardiovascular disease. A greater number of patients will require combinations of agents to achieve optimal lipid control. Accordingly, new agents will be required to provide sufficient choice for patients at high cardiovascular risk.
- Published
- 2021
- Full Text
- View/download PDF
44. Mitochondrial respiratory chain function promotes extracellular matrix integrity in cartilage.
- Author
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Bubb K, Holzer T, Nolte JL, Krüger M, Wilson R, Schlötzer-Schrehardt U, Brinckmann J, Altmüller J, Aszodi A, Fleischhauer L, Clausen-Schaumann H, Probst K, and Brachvogel B
- Subjects
- Animals, Electron Transport, Extracellular Matrix genetics, Mice, Mice, Transgenic, Cartilage metabolism, Extracellular Matrix metabolism, Femur metabolism, RNA-Seq, Single-Cell Analysis
- Abstract
Energy metabolism and extracellular matrix (ECM) function together orchestrate and maintain tissue organization, but crosstalk between these processes is poorly understood. Here, we used single-cell RNA-Seq (scRNA-Seq) analysis to uncover the importance of the mitochondrial respiratory chain for ECM homeostasis in mature cartilage. This tissue produces large amounts of a specialized ECM to promote skeletal growth during development and maintain mobility throughout life. A combined approach of high-resolution scRNA-Seq, mass spectrometry/matrisome analysis, and atomic force microscopy was applied to mutant mice with cartilage-specific inactivation of respiratory chain function. This genetic inhibition in cartilage results in the expansion of a central area of 1-month-old mouse femur head cartilage, showing disorganized chondrocytes and increased deposition of ECM material. scRNA-Seq analysis identified a cell cluster-specific decrease in mitochondrial DNA-encoded respiratory chain genes and a unique regulation of ECM-related genes in nonarticular chondrocytes. These changes were associated with alterations in ECM composition, a shift in collagen/noncollagen protein content, and an increase of collagen crosslinking and ECM stiffness. These results demonstrate that mitochondrial respiratory chain dysfunction is a key factor that can promote ECM integrity and mechanostability in cartilage and presumably also in many other tissues., Competing Interests: Conflict of interest The authors declare that they have no conflicts of interest with the contents of this article., (Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
45. Characterisation of cardiac health in the reduced uterine perfusion pressure model and a 3D cardiac spheroid model, of preeclampsia.
- Author
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Richards C, Sesperez K, Chhor M, Ghorbanpour S, Rennie C, Ming CLC, Evenhuis C, Nikolic V, Orlic NK, Mikovic Z, Stefanovic M, Cakic Z, McGrath K, Gentile C, Bubb K, and McClements L
- Subjects
- Animals, Collagen, Endothelial Cells, Female, Humans, Perfusion, Placenta, Pregnancy, Pregnancy Complications, Cardiovascular, RNA, Messenger, Rats, Rats, Sprague-Dawley, Sex Characteristics, Tacrolimus Binding Proteins, Pre-Eclampsia
- Abstract
Background: Preeclampsia is a dangerous cardiovascular disorder of pregnancy that leads to an increased risk of future cardiovascular and metabolic disorders. Much of the pathogenesis and mechanisms involved in cardiac health in preeclampsia are unknown. A novel anti-angiogenic protein, FKBPL, is emerging as having a potential role in both preeclampsia and cardiovascular disease (CVD). Therefore, in this study we aimed to characterise cardiac health and FKBPL regulation in the rat reduced uterine perfusion pressure (RUPP) and a 3D cardiac spheroid model of preeclampsia., Methods: The RUPP model was induced in pregnant rats and histological analysis performed on the heart, kidney, liver and placenta (n ≥ 6). Picrosirius red staining was performed to quantify collagen I and III deposition in rat hearts, placentae and livers as an indicator of fibrosis. RT-qPCR was used to determine changes in Fkbpl, Icam1, Vcam1, Flt1 and Vegfa mRNA in hearts and/or placentae and ELISA to evaluate cardiac brain natriuretic peptide (BNP45) and FKBPL secretion. Immunofluorescent staining was also conducted to analyse the expression of cardiac FKBPL. Cardiac spheroids were generated using human cardiac fibroblasts and human coronary artery endothelial cells and treated with patient plasma from normotensive controls, early-onset preeclampsia (EOPE) and late-onset preeclampsia (LOPE); n = 3. FKBPL and CD31 expression was quantified by immunofluorescent labelling., Results: The RUPP procedure induced significant increases in blood pressure (p < 0.001), collagen deposition (p < 0.001) and cardiac BNP45 (p < 0.05). It also induced a significant increase in cardiac FKBPL mRNA (p < 0.05) and protein expression (p < 0.01). RUPP placentae also exhibited increased collagen deposition and decreased Flt1 mRNA expression (p < 0.05). RUPP kidneys revealed an increase in average glomerular size (p < 0.05). Cardiac spheroids showed a significant increase in FKBPL expression when treated with LOPE plasma (p < 0.05) and a trend towards increased FKBPL expression following treatment with EOPE plasma (p = 0.06)., Conclusions: The rat RUPP model induced cardiac, renal and placental features reflective of preeclampsia. FKBPL was increased in the hearts of RUPP rats and cardiac spheroids treated with plasma from women with preeclampsia, perhaps reflective of restricted angiogenesis and inflammation in this disorder. Elucidation of these novel FKBPL mechanisms in cardiac health in preeclampsia could be key in preventing future CVD.
- Published
- 2021
- Full Text
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46. Preoperative Delirium Nursing Model Initiatives to Determine the Incidence of Postoperative Delirium Among Elderly Orthopaedic Patients.
- Author
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Wu H, Kapur A, Gibson B, Bubb K, Alrawashdeh M, and Cipkala-Gaffin J
- Subjects
- Aged, Aged, 80 and over, Delirium etiology, Female, Humans, Incidence, Male, Patient Discharge, Risk Factors, Delirium epidemiology, Models, Nursing, Orthopedic Procedures adverse effects, Postoperative Complications etiology
- Abstract
Delirium is a common neurocognitive disorder prevalent in hospitalized older adults. The development of delirium is associated with adverse health outcomes, including functional decline and mortality. This study aimed to investigate the incidence and risk factors of postoperative delirium in older adults (≥60 years) who underwent orthopaedic surgery. Elderly orthopaedic patients were recruited from a large urban hospital over 12 months. Patients were preoperatively screened for delirium and followed up at least once daily postoperatively until discharge. Of the 124 patients in the sample, 21 (16.9%) had postoperative delirium. There were no significant differences in any of the baseline characteristics between the delirious and nondelirious patients. Patients using antidepressants were more likely to develop postoperative delirium compared with those not using antidepressants (odds ratio: 2.72, p = .05). Postoperative delirium was common in this sample of older adults who underwent orthopaedic surgery. Aiming prevention strategies toward patients using antidepressants may help reduce the incidence of delirium in this population., Competing Interests: The authors have disclosed no conflicts of interest., (Copyright © 2021 by National Association of Orthopaedic Nurses.)
- Published
- 2021
- Full Text
- View/download PDF
47. The mystery of evacetrapib - why are CETP inhibitors failing?
- Author
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Nicholls SJ and Bubb K
- Published
- 2020
- Full Text
- View/download PDF
48. Profiling of Accessible Chromatin Regions across Multiple Plant Species and Cell Types Reveals Common Gene Regulatory Principles and New Control Modules.
- Author
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Maher KA, Bajic M, Kajala K, Reynoso M, Pauluzzi G, West DA, Zumstein K, Woodhouse M, Bubb K, Dorrity MW, Queitsch C, Bailey-Serres J, Sinha N, Brady SM, and Deal RB
- Subjects
- Arabidopsis genetics, Conserved Sequence genetics, Solanum lycopersicum genetics, Medicago genetics, Meristem genetics, Oryza genetics, Plant Epidermis cytology, Sequence Analysis, DNA, Species Specificity, Transcription Factors metabolism, Transposases metabolism, Chromatin metabolism, Gene Expression Regulation, Plant, Gene Regulatory Networks, Plant Cells metabolism, Plants genetics
- Abstract
The transcriptional regulatory structure of plant genomes remains poorly defined relative to animals. It is unclear how many cis -regulatory elements exist, where these elements lie relative to promoters, and how these features are conserved across plant species. We employed the assay for transposase-accessible chromatin (ATAC-seq) in four plant species ( Arabidopsis thaliana , Medicago truncatula , Solanum lycopersicum , and Oryza sativa ) to delineate open chromatin regions and transcription factor (TF) binding sites across each genome. Despite 10-fold variation in intergenic space among species, the majority of open chromatin regions lie within 3 kb upstream of a transcription start site in all species. We find a common set of four TFs that appear to regulate conserved gene sets in the root tips of all four species, suggesting that TF-gene networks are generally conserved. Comparative ATAC-seq profiling of Arabidopsis root hair and non-hair cell types revealed extensive similarity as well as many cell-type-specific differences. Analyzing TF binding sites in differentially accessible regions identified a MYB-driven regulatory module unique to the hair cell, which appears to control both cell fate regulators and abiotic stress responses. Our analyses revealed common regulatory principles among species and shed light on the mechanisms producing cell-type-specific transcriptomes during development., (© 2018 American Society of Plant Biologists. All rights reserved.)
- Published
- 2018
- Full Text
- View/download PDF
49. Hearing and Health Outcomes: Recognizing and Addressing Hearing Loss in Hospitalized Older Adults.
- Author
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Mormer E, Cipkala-Gaffin J, Bubb K, and Neal K
- Abstract
As age increases, the prevalence of hearing loss significantly increases, reaching up to 89% of those 80 years and older. Hearing loss in older patients is often unrecognized and its consequences are often underappreciated. Hearing loss can interfere with the ability to exchange important health information and to participate in health care decision-making. Hearing loss during hospitalization increases the risk of misdiagnosis. There is a lack of empirical data regarding prevalence and recognition of hearing loss in hospitalized older adults. In this article, we describe a variety of negative outcomes that may result when older inpatients are functioning with unrecognized hearing loss.
- Published
- 2017
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50. The internal anatomy of the inferior vena cava with specific emphasis on the entrance of the renal, gonadal and lumbar veins.
- Author
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Bubb K, du Plessis M, Hage R, Tubbs RS, and Loukas M
- Subjects
- Aged, Aged, 80 and over, Anatomic Variation, Female, Humans, Male, Middle Aged, Renal Veins anatomy & histology, Vena Cava, Inferior anatomy & histology
- Abstract
Major tributaries such as the renal and adrenal veins have been studied extensively; however, tributaries of the infra-renal segment of the inferior vena cava (IVC) have not been given much attention. Accurate knowledge of the anatomy of these veins is necessary for improved efficacy of surgical interventions in the retroperitoneum. The aim of this study therefore was to provide a comprehensive picture of the internal anatomy of the tributaries of the infra-renal segment of the IVC. Dissection of the posterior abdominal wall was performed on 30 formalin-fixed cadavers. Endoscopic study was carried out followed by a midline venotomy on the anterior wall of the isolated IVC, the location and orientation of its tributaries and their ostia were observed and measurements taken. The results showed that while there was great variation in the drainage pattern of the lumbar veins, most lumbar veins had ostia located between L2 and L3 vertebrae irrespective of the location of renal and gonadal tributaries. Valves were found in 81.81 % of gonadal veins, in 56.60 % of all lumbar veins and discrete ostial valves in 14.81 % of renal veins. The location of the tributaries of the IVC was correlated with the vertebral levels. Empirical data regarding their ostio-valvular complexes were established, which put into question widely accepted concept of valveless tributaries. Our results may implicate surgical procedures in and around the retroperitoneal region.
- Published
- 2016
- Full Text
- View/download PDF
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