4,374 results on '"Bürkle, A"'
Search Results
2. Modeling of Surface Damage at the Si/SiO$_2$-interface of Irradiated MOS-capacitors
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Akchurin, N., Altopp, G., Burkle, B., Frey, W. D., Heintz, U., Hinton, N., Hoeferkamp, M., Kazhykarim, Y., Kuryatkov, V., Mengke, T., Peltola, T., Seidel, S., Spencer, E., Tripathi, M., and Voelker, J.
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Physics - Instrumentation and Detectors - Abstract
Surface damage caused by ionizing radiation in SiO$_2$ passivated silicon particle detectors consists mainly of the accumulation of a positively charged layer along with trapped-oxide-charge and interface traps inside the oxide and close to the Si/SiO$_2$-interface. High density positive interface net charge can be detrimental to the operation of a multi-channel $n$-on-$p$ sensor since the inversion layer generated under the Si/SiO$_2$-interface can cause loss of position resolution by creating a conduction channel between the electrodes. In the investigation of the radiation-induced accumulation of oxide charge and interface traps, a capacitance-voltage characterization study of n/$\gamma$- and $\gamma$-irradiated Metal-Oxide-Semiconductor (MOS) capacitors showed that close agreement between measurement and simulation were possible when oxide charge density was complemented by both acceptor- and donor-type deep interface traps with densities comparable to the oxide charges. Corresponding inter-strip resistance simulations of a $n$-on-$p$ sensor with the tuned oxide charge density and interface traps show close agreement with experimental results. The beneficial impact of radiation-induced accumulation of deep interface traps on inter-electrode isolation may be considered in the optimization of the processing parameters of isolation implants on $n$-on-$p$ sensors for the extreme radiation environments., Comment: Corresponding author: T. Peltola. 24 pages, 17 figures, 6 tables
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- 2023
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3. Associations of circulating GDF15 with combined cognitive frailty and depression in older adults of the MARK-AGE study
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Kochlik, Bastian, Herpich, Catrin, Moreno-Villanueva, María, Klaus, Susanne, Müller-Werdan, Ursula, Weinberger, Birgit, Fiegl, Simone, Toussaint, Olivier, Debacq-Chainiaux, Florence, Schön, Christiane, Bernhard, Jürgen, Breusing, Nicolle, Gonos, Efstathios S., Franceschi, Claudio, Capri, Miriam, Sikora, Ewa, Hervonen, Antti, Hurme, Mikko, Slagboom, P. Eline, Dollé, Martijn E. T., Jansen, Eugene, Grune, Tilman, Bürkle, Alexander, and Norman, Kristina
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- 2024
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4. Deep learning-accelerated image reconstruction in back pain-MRI imaging: reduction of acquisition time and improvement of image quality
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Estler, Arne, Hauser, Till-Karsten, Brunnée, Merle, Zerweck, Leonie, Richter, Vivien, Knoppik, Jessica, Örgel, Anja, Bürkle, Eva, Adib, Sasan Darius, Hengel, Holger, Nikolaou, Konstantin, Ernemann, Ulrike, and Gohla, Georg
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- 2024
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5. Bacterial Contamination of Syringes and Fluids in Diagnostic and Interventional Neuroangiography
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Martin Wiesmann, Sophia Honecker, Claudia Fleu, Christiane Franz, Manuela Schmiech, Hani Ridwan, Franziska Bürkle, Omid Nikoubashman, and Sebastian Lemmen
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angiography ,bacteremia ,contamination ,intervention ,Computer applications to medicine. Medical informatics ,R858-859.7 - Abstract
(1) Background: Bacterial contamination has been shown to occur during angiographies, although data on its frequency and relevance are sparse. Our aim was to evaluate the incidence of bacterial contamination of syringes used under sterile conditions during neuroangiographies. We sought to differentiate between contamination of the outside of the syringes and the inside and to detect the frequency, extent and germ spectrum of bacterial contamination. (2) Methods: We prospectively collected 600 samples from 100 neuroangiographies. Per angiography, fluid samples from the three routinely used syringes as well as the syringes themselves were analyzed. We analyzed the frequency and extent of contamination and determined the germ spectrum. (3) Results: The majority of samples (56.9%) were contaminated. There was no angiography that showed no contamination (0%). The outer surfaces of the syringes were contaminated significantly more frequently and to a higher extent than the inner surfaces. Both the frequency and extent of contamination of the samples increased with longer duration of angiographic procedures. Most of the bacterial species were environmental or skin germs (87.7%). (4) Conclusions: Bacterial contamination is a frequent finding during neuroangiographies, although its clinical significance is believed to be small. Bacterial contamination increases with longer duration of angiographic procedures.
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- 2024
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6. Earlier consolidation and improved knee function of medial open wedge high tibial osteotomy with autologous bone graft
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Bodenbeck, Eva-Maria, Böpple, Jessica C., Doll, Julian, Bürkle, Franziska, Schmidmaier, Gerhard, and Fischer, Christian
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- 2024
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7. Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain
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Sirko, Swetlana, Schichor, Christian, Della Vecchia, Patrizia, Metzger, Fabian, Sonsalla, Giovanna, Simon, Tatiana, Bürkle, Martina, Kalpazidou, Sofia, Ninkovic, Jovica, Masserdotti, Giacomo, Sauniere, Jean-Frederic, Iacobelli, Valentina, Iacobelli, Stefano, Delbridge, Claire, Hauck, Stefanie M., Tonn, Jörg-Christian, and Götz, Magdalena
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- 2023
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8. Die Wahl der richtigen Bildgebung zur Diagnostik und Verlaufsbeurteilung peripherer Nervenverletzungen
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Bürkle, Eva, Ruff, Christer, Lindig, Tobias, Nägele, Thomas, Hauser, Till-Karsten, Grimm, Alexander, and Winter, Natalie
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- 2023
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9. Association between bilirubin and biomarkers of metabolic health and oxidative stress in the MARK-AGE cohort
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Vanessa Schoissengeier, Lina Maqboul, Daniela Weber, Tilman Grune, Alexander Bürkle, Maria Moreno-Villaneuva, Claudio Franceschi, Miriam Capri, Jürgen Bernhard, Olivier Toussaint, Florence Debacq-Chainiaux, Birgit Weinberger, Efstathios S. Gonos, Ewa Sikora, Martijn Dollé, Eugène Jansen, P. Eline Slagboom, Antti Hervonnen, Mikko Hurme, Nicolle Breusing, Jan Frank, Andrew C. Bulmer, and Karl-Heinz Wagner
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pathology ,public health ,human metabolism ,Science - Abstract
Summary: Recent studies have shown that elevated concentrations of unconjugated bilirubin (UCB) may be a protective host factor against the development of noncommunicable diseases (NCDs), whereas low levels of UCB are associated with the opposite effect. The results of this European study, in which 2,489 samples were tested for their UCB concentration using high-performance liquid chromatography (HPLC) and additional data from the MARK-AGE database were used for analysis, provide further evidence that elevated UCB concentrations are linked to a lower risk of developing NCDs and may act as a predictive marker of biological aging as individuals with elevated UCB concentrations showed favorable outcomes in metabolic health and oxidative-stress-related biomarkers. These findings underline the significance of studying individuals with moderate hyperbilirubinemia and investigate UCB routinely, also in the setting of aging, since this condition affects millions of people worldwide but has been underrepresented in clinical research and practice until now.
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- 2024
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10. Impact of the COVID-19 pandemic on training conditions and education in oncologic disciplines: a survey-based analysis
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Trommer, Maike, Adams, Anne, Bürkle, Carolin, Brunner, Stefanie, Grandoch, Andrea, Geffroy, Alexandra, Franklin, Cindy, Gassa, Asmae, Meißner, Anna-Katharina, Mellinghoff, Sibylle, Sharma, Shachi Jenny, Schrittenlocher, Silvia, Witte, Luisa, and Marnitz, Simone
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- 2023
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11. Diagnosis and treatment of MPN in real life: exploratory and retrospective chart review including 960 MPN patients diagnosed with ET or MF in Germany
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Schmidt, Andreas, Bernhardt, Christiane, Bürkle, Dieter, Fries, Stefan, Hannig, Carla V., Jentsch-Ullrich, Kathleen, Josting, Andreas, Kreher, Stephan, Reiser, Marcel, Steinmetz, Hans Tilman, Tesch, Hans, Terner, Stephanie, Schulte, Alexander, Crodel, Carl C., Palandri, Francesca, and Heidel, Florian H.
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- 2023
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12. Response of a CMS HGCAL silicon-pad electromagnetic calorimeter prototype to 20-300 GeV positrons
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Acar, B., Adamov, G., Adloff, C., Afanasiev, S., Akchurin, N., Akgün, B., Khan, F. Alam, Alhusseini, M., Alison, J., Alpana, A., Altopp, G., Alyari, M., An, S., Anagul, S., Andreev, I., Aspell, P., Atakisi, I. O., Bach, O., Baden, A., Bakas, G., Bakshi, A., Bannerjee, S., Bargassa, P., Barney, D., Beaudette, F., Beaujean, F., Becheva, E., Becker, A., Behera, P., Belloni, A., Bergauer, T., Besancon, M., Bhattacharya, S., Bhowmik, D., Bilki, B., Bloch, P., Bodek, A., Bonanomi, M., Bonnemaison, A., Bonomally, S., Borg, J., Bouyjou, F., Bower, N., Braga, D., Brashear, J., Brondolin, E., Bryant, P., Perraguin, A. Buchot, Bueghly, J., Burkle, B., Butler-Nalin, A., Bychkova, O., Callier, S., Calvet, D., Cao, X., Cappati, A., Caraway, B., Caregari, S., Cauchois, A., Ceard, L., Cekmecelioglu, Y. C., Cerci, S., Cerminara, G., Chadeeva, M., Charitonidis, N., Chatterjee, R., Chen, Y. M., Chen, Z., Cheng, H. J., Cheng, K. y., Chernichenko, S., Cheung, H., Chien, C. H., Choudhury, S., Čoko, D., Collura, G., Couderc, F., Danilov, M., Dannheim, D., Daoud, W., Dauncey, P., David, A., Davies, G., Davignon, O., Day, E., DeBarbaro, P., De Guio, F., de La Taille, C., De Silva, M., Debbins, P., Defranchis, M. M., Delagnes, E., Berrio, J. M. Deltoro, Derylo, G., de Almeida, P. G. Dias, Diaz, D., Dinaucourt, P., Dittmann, J., Dragicevic, M., Dugad, S., Dulucq, F., Dumanoglu, I., Dutta, V., Dutta, S., Dünser, M., Eckdahl, J., Edberg, T. K., Berni, M. El, Elias, F., Eno, S. C., Ershov, Yu., Everaerts, P., Extier, S., Fahim, F., Fallon, C., Fedi, G., Alves, B. A. Fontana Santos, Frahm, E., Franzoni, G., Freeman, J., French, T., Gandhi, P., Ganjour, S., Gao, X., Garcia-Bellido, A., Gastaldi, F., Gecse, Z., Geerebaert, Y., Gerwig, H., Gevin, O., Ghosh, S., Gilbert, A., Gilbert, W., Gill, K., Gingu, C., Gninenko, S., Golunov, A., Golutvin, I., Gonzalez, T., Gorbounov, N., Gouskos, L., Gray, A. B., Gu, Y., Guilloux, F., Guler, Y., Gülmez, E., Guo, J., Guler, E. Gurpinar, Hammer, M., Hassanshahi, H. M., Hatakeyama, K., Heering, A., Hegde, V., Heintz, U., Hinton, N., Hirschauer, J., Hoff, J., Hou, W. -S., Hou, X., Hua, H., Incandela, J., Irshad, A., Isik, C., Jain, S., Jheng, H. R., Joshi, U., Kachanov, V., Kalinin, A., Kalipoliti, L., Kaminskiy, A., Kapoor, A., Kara, O., Karneyeu, A., Kaya, M., Kaya, O., Topaksu, A. Kayis, Khukhunaishvili, A., Kiesler, J., Kilpatrick, M., Kim, S., Koetz, K., Kolberg, T., Köseyan, O. K., Kristić, A., Krohn, M., Krüger, K., Kulagin, N., Kulis, S., Kunori, S., Kuo, C. M., Kuryatkov, V., Kyre, S., Lai, Y., Lamichhane, K., Landsberg, G., Lange, C., Langford, J., Lee, M. Y., Levin, A., Li, A., Li, B., Li, J. H., Li, Y. y., Liao, H., Lincoln, D., Linssen, L., Lipton, R., Liu, Y., Lobanov, A., Lu, R. -S., Lupi, M., Lysova, I., Magnan, A. -M., Magniette, F., Mahjoub, A., Maier, A. A., Malakhov, A., Mallios, S., Mandjavize, I., Mannelli, M., Mans, J., Marchioro, A., Martelli, A., Martinez, G., Masterson, P., Meng, B., Mengke, T., Mestvirishvili, A., Mirza, I., Moccia, S., Mohanty, G. B., Monti, F., Morrissey, I., Murthy, S., Musić, J., Musienko, Y., Nabili, S., Nagar, A., Nguyen, M., Nikitenko, A., Noonan, D., Noy, M., Nurdan, K., Ochando, C., Odegard, B., Odell, N., Okawa, H., Onel, Y., Ortez, W., Ozegović, J., Ozkorucuklu, S., Paganis, E., Pagenkopf, D., Palladino, V., Pandey, S., Pantaleo, F., Papageorgakis, C., Papakrivopoulos, I., Parshook, J., Pastika, N., Paulini, M., Paulitsch, P., Peltola, T., Gomes, R. Pereira, Perkins, H., Petiot, P., Pierre-Emile, T., Pitters, F., Popova, E., Prosper, H., Prvan, M., Puljak, I., Qu, H., Quast, T., Quinn, R., Quinnan, M., Garcia, M. T. Ramos, Rao, K. K., Rapacz, K., Raux, L., Reichenbach, G., Reinecke, M., Revering, M., Roberts, A., Romanteau, T., Rose, A., Rovere, M., Roy, A., Rubinov, P., Rusack, R., Rusinov, V., Ryjov, V., Sahin, O. M., Salerno, R., Rodriguez, A. M. Sanchez, Saradhy, R., Sarkar, T., Sarkisla, M. A., Sauvan, J. B., Schmidt, I., Schmitt, M., Scott, E., Seez, C., Sefkow, F., Sharma, S., Shein, I., Shenai, A., Shukla, R., Sicking, E., Sieberer, P., Silva, P., Simsek, A. E., Sirois, Y., Smirnov, V., Sozbilir, U., Spencer, E., Steen, A., Strait, J., Strobbe, N., Su, J. W., Sukhov, E., Sun, L., Cerci, D. Sunar, Syal, C., Tali, B., Tan, C. L., Tao, J., Tastan, I., Tatli, T., Thaus, R., Tekten, S., Thienpont, D., Tiras, E., Titov, M., Tlisov, D., Tok, U. G., Troska, J., Tsai, L. -S., Tsamalaidze, Z., Tsipolitis, G., Tsirou, A., Tyurin, N., Undleeb, S., Urbanski, D., Ustinov, V., Uzunian, A., Van de Klundert, M., Varela, J., Velasco, M., Viazlo, O., Pinto, M. Vicente Barreto, Virdee, P. Vichoudis T., de Oliveira, R. Vizinho, Voelker, J., Voirin, E., Vojinovic, M., Wade, A., Wang, C., Wang, F., Wang, X., Wang, Z., Wayne, M., Webb, S. N., Whitbeck, A., White, D., Wickwire, R., Wilson, J. S., Winter, D., Wu, H. y., Wu, L., Nursanto, M. Wulansatiti, Yeh, C. H, Yohay, R., Yu, D., Yu, G. B., Yu, S. S., Yuan, C., Yumiceva, F., Yusuff, I., Zacharopoulou, A., Zamiatin, N., Zarubin, A., Zenz, S., Zghiche, A., Zhang, H., Zhang, J., Zhang, Y., and Zhang, Z.
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Physics - Instrumentation and Detectors ,High Energy Physics - Experiment - Abstract
The Compact Muon Solenoid Collaboration is designing a new high-granularity endcap calorimeter, HGCAL, to be installed later this decade. As part of this development work, a prototype system was built, with an electromagnetic section consisting of 14 double-sided structures, providing 28 sampling layers. Each sampling layer has an hexagonal module, where a multipad large-area silicon sensor is glued between an electronics circuit board and a metal baseplate. The sensor pads of approximately 1 cm$^2$ are wire-bonded to the circuit board and are readout by custom integrated circuits. The prototype was extensively tested with beams at CERN's Super Proton Synchrotron in 2018. Based on the data collected with beams of positrons, with energies ranging from 20 to 300 GeV, measurements of the energy resolution and linearity, the position and angular resolutions, and the shower shapes are presented and compared to a detailed Geant4 simulation.
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- 2021
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13. Ultrafast Brain MRI at 3 T for MS: Evaluation of a 51-Second Deep Learning-Enhanced T2-EPI-FLAIR Sequence
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Martin Schuhholz, Christer Ruff, Eva Bürkle, Thorsten Feiweier, Bryan Clifford, Markus Kowarik, and Benjamin Bender
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ultrafast brain MRI ,multi-shot EPI ,ultrafast FLAIR ,deep learning ,image acceleration ,image enhancement ,Medicine (General) ,R5-920 - Abstract
In neuroimaging, there is no equivalent alternative to magnetic resonance imaging (MRI). However, image acquisitions are generally time-consuming, which may limit utilization in some cases, e.g., in patients who cannot remain motionless for long or suffer from claustrophobia, or in the event of extensive waiting times. For multiple sclerosis (MS) patients, MRI plays a major role in drug therapy decision-making. The purpose of this study was to evaluate whether an ultrafast, T2-weighted (T2w), deep learning-enhanced (DL), echo-planar-imaging-based (EPI) fluid-attenuated inversion recovery (FLAIR) sequence (FLAIRUF) that has targeted neurological emergencies so far might even be an option to detect MS lesions of the brain compared to conventional FLAIR sequences. Therefore, 17 MS patients were enrolled prospectively in this exploratory study. Standard MRI protocols and ultrafast acquisitions were conducted at 3 tesla (T), including three-dimensional (3D)-FLAIR, turbo/fast spin-echo (TSE)-FLAIR, and FLAIRUF. Inflammatory lesions were grouped by size and location. Lesion conspicuity and image quality were rated on an ordinal five-point Likert scale, and lesion detection rates were calculated. Statistical analyses were performed to compare results. Altogether, 568 different lesions were found. Data indicated no significant differences in lesion detection (sensitivity and positive predictive value [PPV]) between FLAIRUF and axially reconstructed 3D-FLAIR (lesion size ≥3 mm × ≥2 mm) and no differences in sensitivity between FLAIRUF and TSE-FLAIR (lesion size ≥3 mm total). Lesion conspicuity in FLAIRUF was similar in all brain regions except for superior conspicuity in the occipital lobe and inferior conspicuity in the central brain regions. Further findings include location-dependent limitations of signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) as well as artifacts such as spatial distortions in FLAIRUF. In conclusion, FLAIRUF could potentially be an expedient alternative to conventional methods for brain imaging in MS patients since the acquisition can be performed in a fraction of time while maintaining good image quality.
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- 2024
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14. Impact of nitrous oxide use on parturient recall of neuraxial analgesia risks
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Sharpe, Emily E., Warner, Lindsay L., Brakke, Benjamin D., Davis, Paul R., Finkel, David M., Burkle, Christopher M., Hanson, Andrew C., Pompeian, Rochelle J., Arendt, Katherine W., Butler Tobah, Yvonne S., and Sviggum, Hans P.
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- 2024
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15. An electrochemical study of iron carbonate layers formed on carbon steel during corrosion in elevated pressure CO2 environments
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Jacklin, Robert, Owen, Joshua, Sykes, Amber, Burkle, Danny, Woollam, Richard C., and Barker, Richard
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- 2024
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16. Predicting plant–pollinator interactions: concepts, methods, and challenges
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Peralta, Guadalupe, CaraDonna, Paul J., Rakosy, Demetra, Fründ, Jochen, Pascual Tudanca, María P., Dormann, Carsten F., Burkle, Laura A., Kaiser-Bunbury, Christopher N., Knight, Tiffany M., Resasco, Julian, Winfree, Rachael, Blüthgen, Nico, Castillo, William J., and Vázquez, Diego P.
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- 2024
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17. How can social robot use cases in healthcare be pushed - with an interoperable programming interface
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Glauser, Robin, Holm, Jürgen, Bender, Matthias, and Bürkle, Thomas
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- 2023
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18. Stability of silicon–tin alloyed nanocrystals with high tin concentration synthesized by femtosecond laser plasma in liquid media
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Lozac’h, Mickaël, Bürkle, Marius, McDonald, Calum, Miyadera, Tetsuhiko, Koganezawa, Tomoyuki, Mariotti, Davide, and Švrček, Vladimir
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- 2023
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19. Predictive markers related to local and systemic inflammation in severe COVID-19-associated ARDS: a prospective single-center analysis
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Lieberum, Jan Nikolaus, Kaiser, Sandra, Kalbhenn, Johannes, Bürkle, Hartmut, and Schallner, Nils
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- 2023
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20. Acquiring feature-based ordering preferences in English ditransitives
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Bürkle, Daniel, primary
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- 2023
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21. Oxidative stability of hydrocarbons produced by pyrolysis of polypropylene
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Hassibi, Nabil, Benrabah, Ryma, Vega-Bustos, Yireth Andrea, Sirjean, Baptiste, Glaude, Pierre-Alexandre, Mauviel, Guillain, and Burklé-Vitzthum, Valérie
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- 2024
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22. End-to-End Jet Classification of Boosted Top Quarks with the CMS Open Data
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Andrews, Michael, Burkle, Bjorn, Chen, Yi-fan, DiCroce, Davide, Gleyzer, Sergei, Heintz, Ulrich, Narain, Meenakshi, Paulini, Manfred, Pervan, Nikolas, Shafi, Yusef, Sun, Wei, Usai, Emanuele, and Yang, Kun
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Physics - Data Analysis, Statistics and Probability ,Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Machine Learning ,High Energy Physics - Experiment - Abstract
We describe a novel application of the end-to-end deep learning technique to the task of discriminating top quark-initiated jets from those originating from the hadronization of a light quark or a gluon. The end-to-end deep learning technique combines deep learning algorithms and low-level detector representation of the high-energy collision event. In this study, we use low-level detector information from the simulated CMS Open Data samples to construct the top jet classifiers. To optimize classifier performance we progressively add low-level information from the CMS tracking detector, including pixel detector reconstructed hits and impact parameters, and demonstrate the value of additional tracking information even when no new spatial structures are added. Relying only on calorimeter energy deposits and reconstructed pixel detector hits, the end-to-end classifier achieves an AUC score of 0.975$\pm$0.002 for the task of classifying boosted top quark jets. After adding derived track quantities, the classifier AUC score increases to 0.9824$\pm$0.0013, serving as the first performance benchmark for these CMS Open Data samples. We additionally provide a timing performance comparison of different processor unit architectures for training the network., Comment: 9 pages, 3 figures, 4 tables; v3: unpublished
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- 2021
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23. Global Clipper: Enhancing Safety and Reliability of Transformer-based Object Detection Models.
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Syed Sha Qutub, Michael Paulitsch, Karthik Pattabiraman, Korbinian Hagn, Fabian Oboril, Cornelius Bürkle, Kay-Ulrich Scholl, Gereon Hinz, and Alois Knoll
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- 2024
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24. Construction and commissioning of CMS CE prototype silicon modules
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Acar, B., Adamov, G., Adloff, C., Afanasiev, S., Akchurin, N., Akgün, B., Alhusseini, M., Alison, J., Altopp, G., Alyari, M., An, S., Anagul, S., Andreev, I., Andrews, M., Aspell, P., Atakisi, I. A., Bach, O., Baden, A., Bakas, G., Bakshi, A., Bargassa, P., Barney, D., Becheva, E., Behera, P., Belloni, A., Bergauer, T., Besancon, M., Bhattacharya, S., Bhowmik, D., Bloch, P., Bodek, A., Bonanomi, M., Bonnemaison, A., Bonomally, S., Borg, J., Bouyjou, F., Braga, D., Brashear, J., Brondolin, E., Bryant, P., Bueghly, J., Bilki, B., Burkle, B., Butler-Nalin, A., Callier, S., Calvet, D., Cao, X., Caraway, B., Caregari, S., Ceard, L., Cekmecelioglu, Y. C., Cerminara, G., Charitonidis, N., Chatterjee, R., Chen, Y. M., Chen, Z., Cheng, K. y., Chernichenko, S., Cheung, H., Chien, C. H., Choudhury, S., Čoko, D., Collura, G., Couderc, F., Dumanoglu, I., Dannheim, D., Dauncey, P., David, A., Davies, G., Day, E., DeBarbaro, P., De Guio, F., de La Taille, C., De Silva, M., Debbins, P., Delagnes, E., Deltoro, J. M., Derylo, G., de Almeida, P. G. Dias, Diaz, D., Dinaucourt, P., Dittmann, J., Dragicevic, M., Dugad, S., Dutta, V., Dutta, S., Eckdahl, J., Edberg, T. K., Berni, M. El, Eno, S. C., Ershov, Yu., Everaerts, P., Extier, S., Fahim, F., Fallon, C., Alves, B. A. Fontana Santos, Frahm, E., Franzoni, G., Freeman, J., French, T., Guler, E. Gurpinar, Guler, Y., Gagnan, M., Gandhi, P., Ganjour, S., Garcia-Bellido, A., Gecse, Z., Geerebaert, Y., Gerwig, H., Gevin, O., Gilbert, W., Gilbert, A., Gill, K., Gingu, C., Gninenko, S., Golunov, A., Golutvin, I., Gonzalez, T., Gorbounov, N., Gouskos, L., Gu, Y., Guilloux, F., Gülmez, E., Hammer, M., Harilal, A., Hatakeyama, K., Heering, A., Hegde, V., Heintz, U., Hinger, V., Hinton, N., Hirschauer, J., Hoff, J., Hou, W. S., Isik, C., Incandela, J., Jain, S., Jheng, H. R., Joshi, U., Kara, O., Kachanov, V., Kalinin, A., Kameshwar, R., Kaminskiy, A., Karneyeu, A., Kaya, O., Kaya, M., Khukhunaishvili, A., Kim, S., Koetz, K., Kolberg, T., Kristić, A., Krohn, M., Krüger, K., Kulagin, N., Kulis, S., Kunori, S., Kuo, C. M., Kuryatkov, V., Kyre, S., Köseyan, O. K., Lai, Y., Lamichhane, K., Landsberg, G., Langford, J., Lee, M. Y., Levin, A., Li, A., Li, B., Li, J. -H., Liao, H., Lincoln, D., Linssen, L., Lipton, R., Liu, Y., Lobanov, A., Lu, R. S., Lysova, I., Magnan, A. M., Magniette, F., Maier, A. A., Malakhov, A., Mandjavize, I., Mannelli, M., Mans, J., Marchioro, A., Martelli, A., Masterson, P., Meng, B., Mengke, T., Mestvirishvili, A., Mirza, I., Moccia, S., Morrissey, I., Mudholkar, T., Musić, J., Musienko, I., Nabili, S., Nagar, A., Nikitenko, A., Noonan, D., Noy, M., Nurdan, K., Ochando, C., Odegard, B., Odell, N., Onel, Y., Ortez, W., Ozegović, J., Rodriguez, L. Pacheco, Paganis, E., Pagenkopf, D., Palladino, V., Pandey, S., Pantaleo, F., Papageorgakis, C., Papakrivopoulos, I., Parshook, J., Pastika, N., Paulini, M., Paulitsch, P., Peltola, T., Gomes, R. Pereira, Perkins, H., Petiot, P., Pitters, F., Prosper, H., Prvan, M., Puljak, I., Quast, T., Quinn, R., Quinnan, M., Rapacz, K., Raux, L., Reichenbach, G., Reinecke, M., Revering, M., Rodriguez, A., Romanteau, T., Rose, A., Rovere, M., Roy, A., Rubinov, P., Rusack, R., Simsek, A. E., Sozbilir, U., Sahin, O. M., Sanchez, A., Saradhy, R., Sarkar, T., Sarkisla, M. A., Sauvan, J. B., Schmidt, I., Schmitt, M., Scott, E., Seez, C., Sefkow, F., Sharma, S., Shein, I., Shenai, A., Shukla, R., Sicking, E., Sieberer, P., Sirois, Y., Smirnov, V., Spencer, E., Steen, A., Strait, J., Strebler, T., Strobbe, N., Su, J. W., Sukhov, E., Sun, L., Sun, M., Syal, C., Tali, B., Tok, U. G., Topaksu, A. Kayis, Tan, C. L., Tastan, I., Tatli, T., Thaus, R., Tekten, S., Thienpont, D., Pierre-Emile, T., Tiras, E., Titov, M., Tlisov, D., Troska, J., Tsamalaidze, Z., Tsipolitis, G., Tsirou, A., Tyurin, N., Undleeb, S., Urbanski, D., Ustinov, V., Uzunian, A., van de Klundert, M., Varela, J., Velasco, M., Pinto, M. Vicente Barreto, da Silva, P. M., Virdee, T., de Oliveira, R. Vizinho, Voelker, J., Voirin, E., Wang, Z., Wang, X., Wang, F., Wayne, M., Webb, S. N., Weinberg, M., Whitbeck, A., White, D., Wickwire, R., Wilson, J. S., Wu, H. Y., Wu, L., Yeh, C. H, Yohay, R., Yu, G. B., Yu, S. S., Yu, D., Yumiceva, F., Zacharopoulou, A., Zamiatin, N., Zarubin, A., Zenz, S., Zhang, H., and Zhang, J.
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Physics - Instrumentation and Detectors ,High Energy Physics - Experiment - Abstract
As part of its HL-LHC upgrade program, the CMS Collaboration is developing a High Granularity Calorimeter (CE) to replace the existing endcap calorimeters. The CE is a sampling calorimeter with unprecedented transverse and longitudinal readout for both electromagnetic (CE-E) and hadronic (CE-H) compartments. The calorimeter will be built with $\sim$30,000 hexagonal silicon modules. Prototype modules have been constructed with 6-inch hexagonal silicon sensors with cell areas of 1.1~$cm^2$, and the SKIROC2-CMS readout ASIC. Beam tests of different sampling configurations were conducted with the prototype modules at DESY and CERN in 2017 and 2018. This paper describes the construction and commissioning of the CE calorimeter prototype, the silicon modules used in the construction, their basic performance, and the methods used for their calibration., Comment: 35 pages, submitted to JINST
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- 2020
25. The DAQ system of the 12,000 Channel CMS High Granularity Calorimeter Prototype
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Acar, B., Adamov, G., Adloff, C., Afanasiev, S., Akchurin, N., Akgün, B., Alhusseini, M., Alison, J., Altopp, G., Alyari, M., An, S., Anagul, S., Andreev, I., Andrews, M., Aspell, P., Atakisi, I. A., Bach, O., Baden, A., Bakas, G., Bakshi, A., Bargassa, P., Barney, D., Becheva, E., Behera, P., Belloni, A., Bergauer, T., Besancon, M., Bhattacharya, S., Bhowmik, D., Bloch, P., Bodek, A., Bonanomi, M., Bonnemaison, A., Bonomally, S., Borg, J., Bouyjou, F., Braga, D., Brashear, J., Brondolin, E., Bryant, P., Bueghly, J., Bilki, B., Burkle, B., Butler-Nalin, A., Callier, S., Calvet, D., Cao, X., Caraway, B., Caregari, S., Ceard, L., Cekmecelioglu, Y. C., Cerminara, G., Charitonidis, N., Chatterjee, R., Chen, Y. M., Chen, Z., Cheng, K. y., Chernichenko, S., Cheung, H., Chien, C. H., Choudhury, S., Čoko, D., Collura, G., Couderc, F., Dumanoglu, I., Dannheim, D., Dauncey, P., David, A., Davies, G., Day, E., DeBarbaro, P., De Guio, F., de La Taille, C., De Silva, M., Debbins, P., Delagnes, E., Deltoro, J. M., Derylo, G., de Almeida, P. G. Dias, Diaz, D., Dinaucourt, P., Dittmann, J., Dragicevic, M., Dugad, S., Dutta, V., Dutta, S., Eckdahl, J., Edberg, T. K., Berni, M. El, Eno, S. C., Ershov, Yu., Everaerts, P., Extier, S., Fahim, F., Fallon, C., Alves, B. A. Fontana Santos, Frahm, E., Franzoni, G., Freeman, J., French, T., Guler, E. Gurpinar, Guler, Y., Gagnan, M., Gandhi, P., Ganjour, S., Garcia-Bellido, A., Gecse, Z., Geerebaert, Y., Gerwig, H., Gevin, O., Gilbert, W., Gilbert, A., Gill, K., Gingu, C., Gninenko, S., Golunov, A., Golutvin, I., Gonzalez, T., Gorbounov, N., Gouskos, L., Gu, Y., Guilloux, F., Gülmez, E., Hammer, M., Harilal, A., Hatakeyama, K., Heering, A., Hegde, V., Heintz, U., Hinger, V., Hinton, N., Hirschauer, J., Hoff, J., Hou, W. S., Isik, C., Incandela, J., Jain, S., Jheng, H. R., Joshi, U., Kara, O., Kachanov, V., Kalinin, A., Kameshwar, R., Kaminskiy, A., Karneyeu, A., Kaya, O., Kaya, M., Khukhunaishvili, A., Kim, S., Koetz, K., Kolberg, T., Kristić, A., Krohn, M., Krüger, K., Kulagin, N., Kulis, S., Kunori, S., Kuo, C. M., Kuryatkov, V., Kyre, S., Köseyan, O. K., Lai, Y., Lamichhane, K., Landsberg, G., Langford, J., Lee, M. Y., Levin, A., Li, A., Li, B., Li, J. -H., Liao, H., Lincoln, D., Linssen, L., Lipton, R., Liu, Y., Lobanov, A., Lu, R. S., Lysova, I., Magnan, A. M., Magniette, F., Maier, A. A., Malakhov, A., Mandjavize, I., Mannelli, M., Mans, J., Marchioro, A., Martelli, A., Masterson, P., Meng, B., Mengke, T., Mestvirishvili, A., Mirza, I., Moccia, S., Morrissey, I., Mudholkar, T., Musić, J., Musienko, I., Nabili, S., Nagar, A., Nikitenko, A., Noonan, D., Noy, M., Nurdan, K., Ochando, C., Odegard, B., Odell, N., Onel, Y., Ortez, W., Ozegović, J., Rodriguez, L. Pacheco, Paganis, E., Pagenkopf, D., Palladino, V., Pandey, S., Pantaleo, F., Papageorgakis, C., Papakrivopoulos, I., Parshook, J., Pastika, N., Paulini, M., Paulitsch, P., Peltola, T., Gomes, R. Pereira, Perkins, H., Petiot, P., Pitters, F., Prosper, H., Prvan, M., Puljak, I., Quast, T., Quinn, R., Quinnan, M., Rapacz, K., Raux, L., Reichenbach, G., Reinecke, M., Revering, M., Rodriguez, A., Romanteau, T., Rose, A., Rovere, M., Roy, A., Rubinov, P., Rusack, R., Simsek, A. E., Sozbilir, U., Sahin, O. M., Sanchez, A., Saradhy, R., Sarkar, T., Sarkisla, M. A., Sauvan, J. B., Schmidt, I., Schmitt, M., Scott, E., Seez, C., Sefkow, F., Sharma, S., Shein, I., Shenai, A., Shukla, R., Sicking, E., Sieberer, P., Sirois, Y., Smirnov, V., Spencer, E., Steen, A., Strait, J., Strebler, T., Strobbe, N., Su, J. W., Sukhov, E., Sun, L., Sun, M., Syal, C., Tali, B., Tok, U. G., Topaksu, A. Kayis, Tan, C. L., Tastan, I., Tatli, T., Thaus, R., Tekten, S., Thienpont, D., Pierre-Emile, T., Tiras, E., Titov, M., Tlisov, D., Troska, J., Tsamalaidze, Z., Tsipolitis, G., Tsirou, A., Tyurin, N., Undleeb, S., Urbanski, D., Ustinov, V., Uzunian, A., van de Klundert, M., Varela, J., Velasco, M., Pinto, M. Vicente Barreto, da Silva, P. M., Virdee, T., de Oliveira, R. Vizinho, Voelker, J., Voirin, E., Wang, Z., Wang, X., Wang, F., Wayne, M., Webb, S. N., Weinberg, M., Whitbeck, A., White, D., Wickwire, R., Wilson, J. S., Wu, H. Y., Wu, L., Yeh, C. H, Yohay, R., Yu, G. B., Yu, S. S., Yu, D., Yumiceva, F., Zacharopoulou, A., Zamiatin, N., Zarubin, A., Zenz, S., Zhang, H., and Zhang, J.
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Physics - Instrumentation and Detectors ,High Energy Physics - Experiment - Abstract
The CMS experiment at the CERN LHC will be upgraded to accommodate the 5-fold increase in the instantaneous luminosity expected at the High-Luminosity LHC (HL-LHC). Concomitant with this increase will be an increase in the number of interactions in each bunch crossing and a significant increase in the total ionising dose and fluence. One part of this upgrade is the replacement of the current endcap calorimeters with a high granularity sampling calorimeter equipped with silicon sensors, designed to manage the high collision rates. As part of the development of this calorimeter, a series of beam tests have been conducted with different sampling configurations using prototype segmented silicon detectors. In the most recent of these tests, conducted in late 2018 at the CERN SPS, the performance of a prototype calorimeter equipped with ${\approx}12,000\rm{~channels}$ of silicon sensors was studied with beams of high-energy electrons, pions and muons. This paper describes the custom-built scalable data acquisition system that was built with readily available FPGA mezzanines and low-cost Raspberry PI computers.
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- 2020
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26. HistoDepth - Novel Depth Perception for Safe Collaborative Robots.
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Cornelius Bürkle, Fabian Oboril, and Kay-Ulrich Scholl
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- 2023
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27. HistoGrid: Robust LiDAR-Based Traffic Monitoring.
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Cornelius Bürkle, Fabian Oboril, Omar Zayed, and Kay-Ulrich Scholl
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- 2023
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28. Unleashing the global potential of public health: A framework for future pandemic response
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Khorram-Manesh, Amir, Goniewicz, Krzysztof, and Burkle, Frederick M., Jr
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- 2024
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29. Stroke-like-migraine-attacks-after-radiation-therapy(SMART)-Syndrom: eine seltene Folge nach zerebraler Strahlentherapie
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Straub, Stephanie, Bürkle, Eva, and Grimm, Alexander
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- 2023
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30. Circulating cell-free DNA in health and disease — the relationship to health behaviours, ageing phenotypes and metabolomics
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Kananen, Laura, Hurme, Mikko, Bürkle, Alexander, Moreno-Villanueva, Maria, Bernhardt, Jürgen, Debacq-Chainiaux, Florence, Grubeck-Loebenstein, Beatrix, Malavolta, Marco, Basso, Andrea, Piacenza, Francesco, Collino, Sebastiano, Gonos, Efstathios S., Sikora, Ewa, Gradinaru, Daniela, Jansen, Eugene H. J. M., Dollé, Martijn E. T., Salmon, Michel, Stuetz, Wolfgang, Weber, Daniela, Grune, Tilman, Breusing, Nicolle, Simm, Andreas, Capri, Miriam, Franceschi, Claudio, Slagboom, Eline, Talbot, Duncan, Libert, Claude, Raitanen, Jani, Koskinen, Seppo, Härkänen, Tommi, Stenholm, Sari, Ala-Korpela, Mika, Lehtimäki, Terho, Raitakari, Olli T., Ukkola, Olavi, Kähönen, Mika, Jylhä, Marja, and Jylhävä, Juulia
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- 2023
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31. PARP1 and XRCC1 exhibit a reciprocal relationship in genotoxic stress response
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Reber, Julia M., Božić-Petković, Jovana, Lippmann, Michelle, Mazzardo, Marvin, Dilger, Asisa, Warmers, Rebecca, Bürkle, Alexander, and Mangerich, Aswin
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- 2023
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32. How can social robot use cases in healthcare be pushed - with an interoperable programming interface
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Robin Glauser, Jürgen Holm, Matthias Bender, and Thomas Bürkle
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Interface ,Robotics ,Healthcare ,Python ,Middleware ,Websocket ,Computer applications to medicine. Medical informatics ,R858-859.7 - Abstract
Abstract Introduction Research into current robot middleware has revealed that most of them are either too complicated or outdated. These facts have motivated the development of a new middleware to meet the requirements of usability by non-experts. The proposed middleware is based on Android and is intended to be placed over existing robot SDKs and middleware. It runs on the android tablet of the Cruzr robot. Various toolings have been developed, such as a web component to control the robot via a webinterface, which facilitates its use. Methods The middleware was developed using Android Java and runs on the Cruzr tablet as an app. It features a WebSocket server that interfaces with the robot and allows control via Python or other WebSocket-compatible languages. The speech interface utilizes Google Cloud Voice text-to-speech and speech-to-text services. The interface was implemented in Python, allowing for easy integration with existing robotics development workflows, and a web interface was developed for direct control of the robot via the web. Results The new robot middleware was created and deployed on a Cruzr robot, relying on the WebSocket API and featuring a Python implementation. It supports various robot functions, such as text-to-speech, speech-to-text, navigation, displaying content and scanning bar codes. The system’s architecture allows for porting the interface to other robots and platforms, showcasing its adaptability. It has been demonstrated that the middleware can be run on a Pepper robot, although not all functions have been implemented yet. The middleware was utilized to implement healthcare use cases and received good feedback. Conclusion Cloud and local speech services were discussed in regard to the middleware’s needs, to run without having to change any code on other robots. An outlook on how the programming interface can further be simplified by using natural text to code generators has been/is given. For other researchers using the aforementioned platforms (Cruzr, Pepper), the new middleware can be utilized for testing human-robot interaction. It can be used in a teaching setting, as well as be adapted to other robots using the same interface and philosophy regarding simple methods.
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- 2023
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33. Stability of silicon–tin alloyed nanocrystals with high tin concentration synthesized by femtosecond laser plasma in liquid media
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Mickaël Lozac’h, Marius Bürkle, Calum McDonald, Tetsuhiko Miyadera, Tomoyuki Koganezawa, Davide Mariotti, and Vladimir Švrček
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Medicine ,Science - Abstract
Abstract Nanocrystals have a great potential for future materials with tunable bandgap, due to their optical properties that are related with the material used, their sizes and their surface termination. Here, we concentrate on the silicon–tin alloy for photovoltaic applications due to their bandgap, lower than bulk Si, and also the possibility to activate direct band to band transition for high tin concentration. We synthesized silicon–tin alloy nanocrystals (SiSn-NCs) with diameter of about 2–3 nm by confined plasma technique employing a femtosecond laser irradiation on amorphous silicon–tin substrate submerged in liquid media. The tin concentration is estimated to be $$\sim 17\%$$ ∼ 17 % , being the highest Sn concentration for SiSn-NCs reported so far. Our SiSn-NCs have a well-defined zinc-blend structure and, contrary to pure tin NCs, also an excellent thermal stability comparable to highly stable silicon NCs. We demonstrate by means of high resolution synchrotron XRD analysis (SPring 8) that the SiSn-NCs remain stable from room temperature up to $$400\,^{\circ }\text {C},$$ 400 ∘ C , with a relatively small expansion of the crystal lattice. The high thermal stability observed experimentally is rationalized by means of first-principle calculations.
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- 2023
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- View/download PDF
34. Charge Collection and Electrical Characterization of Neutron Irradiated Silicon Pad Detectors for the CMS High Granularity Calorimeter
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Akchurin, N., Almeida, P., Altopp, G., Alyari, M., Bergauer, T., Brondolin, E., Burkle, B., Frey, W. D., Gecse, Z., Heintz, U., Hinton, N., Kuryatkov, V., Lipton, R., Mannelli, M., Mengke, T., Paulitsch, P., Peltola, T., Pitters, F., Sicking, E., Spencer, E., Tripathi, M., Pinto, M. Vicente Barreto, Voelker, J., Wang, Z., and Yohay, R.
- Subjects
Physics - Instrumentation and Detectors - Abstract
The replacement of the existing endcap calorimeter in the Compact Muon Solenoid (CMS) detector for the high-luminosity LHC (HL-LHC), scheduled for 2027, will be a high granularity calorimeter. It will provide detailed position, energy, and timing information on electromagnetic and hadronic showers in the immense pileup of the HL-LHC. The High Granularity Calorimeter (HGCAL) will use 120-, 200-, and 300-$\mu\textrm{m}$ thick silicon (Si) pad sensors as the main active material and will sustain 1-MeV neutron equivalent fluences up to about $10^{16}~\textrm{n}_\textrm{eq}\textrm{cm}^{-2}$. In order to address the performance degradation of the Si detectors caused by the intense radiation environment, irradiation campaigns of test diode samples from 8-inch and 6-inch wafers were performed in two reactors. Characterization of the electrical and charge collection properties after irradiation involved both bulk polarities for the three sensor thicknesses. Since the Si sensors will be operated at -30 $^\circ$C to reduce increasing bulk leakage current with fluence, the charge collection investigation of 30 irradiated samples was carried out with the infrared-TCT setup at -30 $^\circ$C. TCAD simulation results at the lower fluences are in close agreement with the experimental results and provide predictions of sensor performance for the lower fluence regions not covered by the experimental study. All investigated sensors display 60$\%$ or higher charge collection efficiency at their respective highest lifetime fluences when operated at 800 V, and display above 90$\%$ at the lowest fluence, at 600 V. The collected charge close to the fluence of $10^{16}~\textrm{n}_\textrm{eq}\textrm{cm}^{-2}$ exceeds 1 fC at voltages beyond 800 V., Comment: 36 pages, 34 figures
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- 2020
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35. In situ SR-XRD analysis of corrosion product formation during ‘pseudo-passivation’ of carbon steel in CO2-containing aqueous environments
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Owen, Joshua, Burkle, Danny, Joshi, Gaurav R., Basilico, Edoardo, Kittel, Jean, Ropital, Francois, Marcelin, Sabrina, Kleppe, Annette, Woollam, Richard C., and Barker, Richard
- Published
- 2023
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36. Rapidly evolving cerebral edema and hyperperfusion in a patient with dural arteriovenous fistula
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Bürkle, Eva, Lindig, Tobias, Ernemann, Ulrike, and Rattay, Tim W.
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- 2023
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37. End-to-end particle and event identification at the Large Hadron Collider with CMS Open Data
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Alison, John, An, Sitong, Andrews, Michael, Bryant, Patrick, Burkle, Bjorn, Gleyzer, Sergei, Heintz, Ulrich, Narain, Meenakshi, Paulini, Manfred, Poczos, Barnabas, and Usai, Emanuele
- Subjects
High Energy Physics - Experiment ,Physics - Instrumentation and Detectors - Abstract
From particle identification to the discovery of the Higgs boson, deep learning algorithms have become an increasingly important tool for data analysis at the Large Hadron Collider (LHC). We present an innovative end-to-end deep learning approach for jet identification at the Compact Muon Solenoid (CMS) experiment at the LHC. The method combines deep neural networks with low-level detector information, such as calorimeter energy deposits and tracking information, to build a discriminator to identify different particle species. Using two physics examples as references: electron vs. photon discrimination and quark vs. gluon discrimination, we demonstrate the performance of the end-to-end approach on simulated events with full detector geometry as available in the CMS Open Data. We also offer insights into the importance of the information extracted from various sub-detectors and describe how end-to-end techniques can be extended to event-level classification using information from the whole CMS detector., Comment: Talk presented at the 2019 Meeting of the Division of Particles and Fields of the American Physical Society (DPF2019), July 29 - August 2, 2019, Northeastern University, Boston, C1907293
- Published
- 2019
38. Airway transcriptome networks identify susceptibility to frequent asthma exacerbations in children
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Phelan, Kieran J., Dill-McFarland, Kimberly A., Kothari, Arjun, Segnitz, R. Max, Burkle, Jeff, Grashel, Brittany, Jenkins, Seth, Spagna, Daniel, Martin, Lisa J., Haslam, David B., Biagini, Jocelyn M., Kalra, Maninder, McCoy, Karen S., Ross, Kristie R., Jackson, Daniel J., Mersha, Tesfaye B., Altman, Matthew C., and Khurana Hershey, Gurjit K.
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- 2023
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- View/download PDF
39. End-to-End Jet Classification of Quarks and Gluons with the CMS Open Data
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Andrews, Michael, Alison, John, An, Sitong, Bryant, Patrick, Burkle, Bjorn, Gleyzer, Sergei, Narain, Meenakshi, Paulini, Manfred, Poczos, Barnabas, and Usai, Emanuele
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High Energy Physics - Experiment ,Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Machine Learning ,Physics - Data Analysis, Statistics and Probability - Abstract
We describe the construction of end-to-end jet image classifiers based on simulated low-level detector data to discriminate quark- vs. gluon-initiated jets with high-fidelity simulated CMS Open Data. We highlight the importance of precise spatial information and demonstrate competitive performance to existing state-of-the-art jet classifiers. We further generalize the end-to-end approach to event-level classification of quark vs. gluon di-jet QCD events. We compare the fully end-to-end approach to using hand-engineered features and demonstrate that the end-to-end algorithm is robust against the effects of underlying event and pile-up., Comment: 10 pages, 5 figures, 7 tables; v2: published version
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- 2019
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40. Comparative analysis of chlorambucil-induced DNA lesion formation and repair in a spectrum of different human cell systems
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Sarah Ceylan Krassnig, Marina Mäser, Nicola Anna Probst, Jens Werner, Charlotte Schlett, Nina Schumann, Gudrun von Scheven, Aswin Mangerich, and Alexander Bürkle
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Nitrogen mustard ,Chlorambucil ,Interstrand crosslink ,Monoalkylated DNA adducts ,DNA repair kinetics ,Mass spectrometry ,Toxicology. Poisons ,RA1190-1270 - Abstract
Chlorambucil (CLB) belongs to the class of nitrogen mustards (NMs), which are highly reactive bifunctional alkylating agents and were the first chemotherapeutic agents developed. They form DNA interstrand crosslinks (ICLs), which cause a blockage of DNA strand separation, inhibiting essential processes in DNA metabolism like replication and transcription. In fast replicating cells, e.g., tumor cells, this can induce cell death. The upregulation of ICL repair is thought to be a key factor for the resistance of tumor cells to ICL-inducing cytostatic agents including NMs. To monitor induction and repair of CLB-induced ICLs, we adjusted the automated reversed fluorometric analysis of alkaline DNA unwinding assay (rFADU) for the detection of ICLs in adherent cells. For the detection of monoalkylated DNA bases we established an LC-MS/MS method. We performed a comparative analysis of adduct formation and removal in five human cell lines and in peripheral blood mononuclear cells (PBMCs) after treatment with CLB. Dose-dependent increases in adduct formation were observed, and suitable treatment concentrations were identified for each cell line, which were then used for monitoring the kinetics of adduct formation. We observed significant differences in the repair kinetics of the cell lines tested. For example, in A2780 cells, hTERT immortalized VH10 cells, and in PBMCs a time-dependent repair of the two main monoalkylated DNA-adducts was confirmed. Regarding ICLs, repair was observed in all cell systems except for PBMCs. In conclusion, LC-MS/MS analyses combined with the rFADU technique are powerful tools to study the molecular mechanisms of NM-induced DNA damage and repair. By applying these methods to a spectrum of human cell systems of different origin and transformation status, we obtained insight into the cell-type specific repair of different CLB-induced DNA lesions, which may help identify novel resistance mechanisms of tumors and define molecular targets for therapeutic interventions.
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- 2023
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41. Predictive markers related to local and systemic inflammation in severe COVID-19-associated ARDS: a prospective single-center analysis
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Jan Nikolaus Lieberum, Sandra Kaiser, Johannes Kalbhenn, Hartmut Bürkle, and Nils Schallner
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COVID-19 ,ICU ,TLR3 ,IL-6 ,IL-8 ,Carboxyhemoglobin ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background As the COVID-19 pandemic strains healthcare systems worldwide, finding predictive markers of severe courses remains urgent. Most research so far was limited to selective questions hindering general assumptions for short- and long-term outcome. Methods In this prospective single-center biomarker study, 47 blood- and 21 bronchoalveolar lavage (BAL) samples were collected from 47 COVID-19 intensive care unit (ICU) patients upon admission. Expression of inflammatory markers toll-like receptor 3 (TLR3), heme oxygenase-1 (HO-1), interleukin (IL)-6, IL-8, leukocyte counts, procalcitonin (PCT) and carboxyhemoglobin (CO-Hb) was compared to clinical course. Clinical assessment comprised acute local organ damage, acute systemic damage, mortality and outcome after 6 months. Results PCT correlated with acute systemic damage and was the best predictor for quality of life (QoL) after 6 months (r = − 0.4647, p = 0.0338). Systemic TLR3 negatively correlated with impaired lung function (ECMO/ECLS: r = − 0.3810, p = 0.0107) and neurological short- (RASS mean: r = 0.4474, p = 0.0023) and long-term outcome (mRS after 6 m: r = − 0.3184, p = 0.0352). Systemic IL-8 correlated with impaired lung function (ECMO/ECLS: r = 0.3784, p = 0.0161) and neurological involvement (RASS mean: r = − 0.5132, p = 0.0007). IL-6 in BAL correlated better to the clinical course than systemic IL-6. Using three multivariate regression models, we describe prediction models for local and systemic damage as well as QoL. CO-Hb mean and max were associated with higher mortality. Conclusions Our predictive models using the combination of Charlson Comorbidity Index, sex, procalcitonin, systemic TLR3 expression and IL-6 and IL-8 in BAL were able to describe a broad range of clinically relevant outcomes in patients with severe COVID-19-associated ARDS. Using these models might proof useful in risk stratification and predicting disease course in the future. Trial registration The trial was registered with the German Clinical Trials Register (Trial-ID DRKS00021522, registered 22/04/2020).
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- 2023
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42. New perspectives for investigating muscular perfusion response after dietary supplement intake: an exploratory, randomized, double-blind, placebo-controlled crossover trial in healthy young athletes using contrast-enhanced ultrasound (CEUS)
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Franziska Bürkle, Julian Doll, Arndt Neide, Simone Gantz, Stefanos Tsitlakidis, and Christian Fischer
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contrast-enhanced ultrasound ,ceus ,muscle perfusion ,dietary supplements ,resistance training ,feasibility ,Nutrition. Foods and food supply ,TX341-641 ,Sports medicine ,RC1200-1245 - Abstract
Background Various dietary supplements have been reported to enhance muscular perfusion in athletes practicing resistance training, especially through modulation of nitric oxide signaling. Objectives The aim of this study was therefore to investigate selected ‘NO-boosting’ supplements in a real-life setting i) to generate novel hypotheses and perfusion estimates for power calculation in view of a definitive trial and ii) to assess the feasibility of the study design with particular focus on the use of contrast-enhanced ultrasound (CEUS) for perfusion quantification. Methods Thirty young male athletes (24 ± 4 years) regularly practicing resistance training were enrolled in this three-arm, placebo(PL)-controlled crossover trial with ingestion of two commercially available supplements: an amino acid combination (AA) (containing 3 g of L-arginine-hydrochloride and 8 g of L-citrulline-malate) and 300 mg of a specific green tea extract (GTE). After intake, CEUS examinations of the dominant biceps brachii muscle were performed under resting conditions and following standardized resistance exercising. Quantitative parameters of biceps perfusion (peak enhancement, PE; wash-in perfusion index, WiPI) and caliber were derived from corresponding CEUS video files. Additionally, subjective muscle pump was determined after exercise. Results For PE, WiPI, and biceps caliber, the standard deviation (SD) of the within-subject differences between PL, AA, and GTE was determined, thereby allowing future sample size calculations. No significant differences between PL, AA, and GTE were observed for biceps perfusion, caliber, or muscle pump. When comparing resting with post-exercise measurements, the increase in biceps perfusion significantly correlated with the caliber increase (PE: r = 0.266, p = 0.0113; WiPI: r = 0.269, p = 0.0105). Similarly, the biceps perfusion correlated with muscle pump in the post-exercise conditions (PE: r = 0.354, p = 0.0006; WiPI: r = 0.350, p = 0.0007). A high participant adherence was achieved, and the acquisition of good quality CEUS video files was feasible. No adverse events occurred. Conclusion Based on our novel examination protocol, CEUS seems to be feasible following higher-load resistance exercising and may be used as a new method for high-resolution perfusion quantification to investigate the effects of pre-exercise dietary supplementation on muscle perfusion and related muscle size dynamics.
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- 2022
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43. Proof of principle for the clinical use of a CE-certified automatic imaging analysis tool in rare diseases studying hereditary spastic paraplegia type 4 (SPG4)
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Tobias Lindig, Benjamin Bender, Eva Bürkle, Vinod Kumar, Ulrike Ernemann, Ludger Schöls, and Tim W. Rattay
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Medicine ,Science - Abstract
Abstract Usage of MR imaging biomarkers is limited to experts. Automatic quantitative reports provide access for clinicians to data analysis. Automated data analysis was tested for usability in a small cohort of patients with hereditary spastic paraplegia type 4 (SPG4). We analyzed 3T MRI 3D-T1 datasets of n = 25 SPG4 patients and matched healthy controls using a commercial segmentation tool (AIRAscore structure 2.0.1) and standard VBM. In SPG4 total brain volume was reduced by 27.6 percentiles (p = 0.001) caused mainly by white matter loss (− 30.8th, p
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- 2022
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44. ISLES 2022: A multi-center magnetic resonance imaging stroke lesion segmentation dataset
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Moritz R. Hernandez Petzsche, Ezequiel de la Rosa, Uta Hanning, Roland Wiest, Waldo Valenzuela, Mauricio Reyes, Maria Meyer, Sook-Lei Liew, Florian Kofler, Ivan Ezhov, David Robben, Alexandre Hutton, Tassilo Friedrich, Teresa Zarth, Johannes Bürkle, The Anh Baran, Björn Menze, Gabriel Broocks, Lukas Meyer, Claus Zimmer, Tobias Boeckh-Behrens, Maria Berndt, Benno Ikenberg, Benedikt Wiestler, and Jan S. Kirschke
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Science - Abstract
Abstract Magnetic resonance imaging (MRI) is an important imaging modality in stroke. Computer based automated medical image processing is increasingly finding its way into clinical routine. The Ischemic Stroke Lesion Segmentation (ISLES) challenge is a continuous effort to develop and identify benchmark methods for acute and sub-acute ischemic stroke lesion segmentation. Here we introduce an expert-annotated, multicenter MRI dataset for segmentation of acute to subacute stroke lesions ( https://doi.org/10.5281/zenodo.7153326 ). This dataset comprises 400 multi-vendor MRI cases with high variability in stroke lesion size, quantity and location. It is split into a training dataset of n = 250 and a test dataset of n = 150. All training data is publicly available. The test dataset will be used for model validation only and will not be released to the public. This dataset serves as the foundation of the ISLES 2022 challenge ( https://www.isles-challenge.org/ ) with the goal of finding algorithmic methods to enable the development and benchmarking of automatic, robust and accurate segmentation methods for ischemic stroke.
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- 2022
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45. Expression of DNA repair genes and its relevance for DNA repair in peripheral immune cells of patients with posttraumatic stress disorder
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Alexander Behnke, Matthias Mack, Judy Fieres, Markus Christmann, Alexander Bürkle, María Moreno-Villanueva, and Iris-Tatjana Kolassa
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Medicine ,Science - Abstract
Abstract Posttraumatic stress disorder (PTSD) involves elevated levels of cellular oxidative stress which jeopardizes the integrity of essential cell compartments. Previously, we demonstrated higher levels of DNA lesions in peripheral blood mononuclear cells (PBMCs) in PTSD. Retaining vital levels of DNA integrity requires cells to mobilize compensatory efforts in elevating their DNA-repair capacity. Accordingly, we hypothesized to find increased expression rates of the DNA-repair genes X-ray repair cross complementing 1 (XRCC1), poly (ADP-ribose) polymerase 1 (PARP1), and polymerase β (Polβ) in PBMCs of PTSD patients as compared to controls, leading to functionally relevant changes in DNA-repair kinetics. In a cohort of 14 refugees with PTSD and 15 without PTSD, we found significantly higher XRCC1 expression in PTSD patients than controls (U = 161.0, p = 0.009, Cohen’s r = 0.49), and positive correlations between the severity of PTSD symptoms and the expression of XRCC1 (r S = 0.57, p = 0.002) and PARP1 (r S = 0.43, p = 0.022). Higher XRCC1 (F = 2.39, p = 0.010, η2 p = 0.10) and PARP1 (F = 2.15, p = 0.022, η2 p = 0.09) expression accounted for slower repair of experimentally X-ray irradiation-induced DNA damage, highlighting the possible physiological relevance of altered DNA-repair gene expression in PTSD. Our study provides first evidence for a compensatory regulation of DNA-repair mechanisms in PTSD. We discuss the implications of increased DNA damage and altered DNA-repair mechanisms in immune senescence, premature aging, and increased physical morbidity in PTSD.
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- 2022
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46. Habitat characteristics structuring bee communities in a forest-shrubland ecotone
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Glenny, Will, Runyon, Justin B., and Burkle, Laura A.
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- 2023
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47. Remittances and Migrating Spaces in the Context of Turkish, Vietnamese, and Korean Remigration
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Bürkle, Stefanie, primary
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- 2023
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48. Ausbildung und Training
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Bürkle, Hartmut, primary
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- 2023
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49. Safe Perception - A Hierarchical Monitor Approach.
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Cornelius Bürkle, Fabian Oboril, Johannes Burr, and Kay-Ulrich Scholl
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- 2022
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50. Safety Implications of Runtime Adaptation to Changing Operating Conditions.
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Aniket Salvi, Gereon Weiss, Mario Trapp, Fabian Oboril, and Cornelius Bürkle
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- 2022
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