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The observation of short gamma ray bursts (SGRBs) in the TeV energy range plays an important role in understanding the radiation mechanism and probing new areas of physics such as Lorentz invariance violation. However, no SGRB has been observed in this energy range due to the short duration of SGRBs and the weakness of current experiments. New experiments with new technology are required to detect sub-TeV SGRBs. In this work, we observe the very high energy (VHE) $γ$-ray emissions from SGRBs and calculate the annual detection rate with the High Altitude Detection of Astronomical Radiation HADAR (HADAR) experiment. First, a set of pseudo-SGRB samples is generated and checked using the observations of Fermi-GBM, Fermi-LAT, and SWIFT measurements. The annual detection rate is calculated from these SGRB samples based on the performance of the HADAR instrument. As a result, the HADAR experiment can detect 0.5 SGRB per year if the spectral break-off of $γ$-rays caused by the internal absorption is larger than 100 GeV. For a GRB09010-like GRB in HADAR's view, it should be possible to detect approximately 2000 photons considering the internal absorption. With a time delay assumption due to the Lorentz invariance violation effects, a simulated light curve of GRB090510 has evident energy dependence. We hope that the HADAR experiment can perform the SGRB observations and test our calculations in the future.

Motivated by a specific type of semi-batch biotechnology manufacturing, perfusion, we develop insights into biopharmaceutical production planning and inventory control in two areas. First, at the production site, we consider a continuous time infinite horizon lot-sizing model where a single product is manufactured on a single machine. Each time manufacturing restarts, a random production rate is realized, and production continues at this rate until the machine is shut down. Although the rate is random and chosen from an arbitrary set of random rates, it is known as soon as production starts, so this information could be used to determine when to stop production. Based on the production planning models, we show that given the objective of minimizing either average cost per unit time or total discounted cost, it is optimal to produce up to the same inventory level regardless of the realized production rate; even when backorder allowed, it is optimal to keep the same maximum backorder position. We also develop heuristics for the multi-product version of this production model. Next, for two-stage manufacturing supply chains, we extend this model to consider a specific characteristic of biopharmaceutical inventory planning -- both intermediates and finished goods expire, but the expiration "clock" is restarted at each stage. We propose a two-stage production-inventory integrated model for this setting and develop two heuristics for this model -- fixed size and fixed ratio shipment policies.

To inquiry the status of in awareness, behavior and attitude of sexual and reproductive health of college students in Guangzhou city, and to provide scientific basis for the promotion and education of sexual and reproductive health in college. An investigation was carried out on this issue. Questionnaire survey was used as mainly method that involved 608 students form five universities as respondents. Feedback data show that students had better awareness of condom use (92.60%) and contraception in physiological safety period (61.51%), but had lower awareness of subcutaneous implantation (4.6%), emergency contraception (28.13%) or partial short-acting oral contraceptive (30.59%). Some knowledge of syphilis (89.64%) and gonorrhea (69.41%), but lack of knowledge of condyloma acuminatum (28.61%), non-gonococcal urethritis (17.10%), vaginitis (26.64%) and other venereal diseases. Lack of specific skills to prevent unintended pregnancy and sexually transmitted diseases, only 25.33% of students know the correct use of condoms. College students' knowledge of sexual and reproductive health is not optimistic, and there is a certain misunderstanding of knowledge, to prevent unintended pregnancy, prevention of sexually transmitted diseases and other related skills are far from enough. Colleges and universities should strengthen the publicity and education of sexual and reproductive health knowledge of college students, enhance their consciousness and ability of youth health, and ensure their physical and mental health.

To meet the demand of the higher precision ratio and recall ratio of service search, a method of Web service discovery is proposed based on ontology evolution and Web service migration. According to the developed cloud service platform and the existed service repository and domain ontology list, a service migration process is proposed which migrate to the cloud platform and implement unified management for Web service. This process effectively achieves that Web services migrate in and out of the cloud platform. In order to realize the self-evolution of domain ontology, an ontology alignment mechanism is designed to automatic extend and replace of ontology concept. This mechanism achieves the integration of different keywords with the same meaning and ensures the consistency of ontology concept. In this paper, the method not only enables efficient service discovery and dynamic service management, but also can achieve high concurrency support of services and supply or billing on demand. The experiments show that the proposed method solves the search problem of low efficiency based on keyword, and it effectively improves the precision ratio and recall ratio of service discovery.

According to the feature of the JBPM workflow system development, the target code generated is determined by analyzing the process of JBPM workflow development and the architecture of J2EE. The code generation tool generates code by parsing the static form source code and loading the code generation template. The code generation tool greatly shortens the JBPM workflow system development cycle and reduces the cost of software development which has the good practicality and scalability.