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869 results on '"Bruzzese, Dario"'

3. Platelet Inhibition with Ticagrelor 60 mg Versus 90 mg Twice Daily in Elderly Patients with Acute Coronary Syndrome: Rationale and Design of the PLINY THE ELDER Trial

Author

Piccolo, Raffaele, Avvedimento, Marisa, Canonico, Mario Enrico, Gargiulo, Paola, Paolillo, Roberta, Conti, Valeria, Dal Piaz, Fabrizio, Filippelli, Amelia, Morisco, Carmine, Simonetti, Fiorenzo, Leone, Attilio, Marenna, Alessandra, Bruzzese, Dario, Gargiulo, Giuseppe, Stabile, Eugenio, Di Serafino, Luigi, Franzone, Anna, Cirillo, Plinio, and Esposito, Giovanni

Published
2023
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10. High levels of blood circulating immune checkpoint molecules in children with new-onset type 1 diabetes are associated with the risk of developing an additional autoimmune disease

Author

Bruzzaniti, Sara, Piemonte, Erica, Mozzillo, Enza, Bruzzese, Dario, Lepore, Maria Teresa, Carbone, Fortunata, de Candia, Paola, Strollo, Rocky, Porcellini, Antonio, Marigliano, Marco, Maffeis, Claudio, Bifulco, Maurizio, Ludvigsson, Johnny, Franzese, Adriana, Matarese, Giuseppe, and Galgani, Mario

Published
2022
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11. Progressive Depletion of B and T Lymphocytes in Patients with Ataxia Telangiectasia: Results of the Italian Primary Immunodeficiency Network

Author

Cirillo, Emilia, Polizzi, Agata, Soresina, Annarosa, Prencipe, Rosaria, Giardino, Giuliana, Cancrini, Caterina, Finocchi, Andrea, Rivalta, Beatrice, Dellepiane, Rosa M., Baselli, Lucia A., Montin, Davide, Trizzino, Antonino, Consolini, Rita, Azzari, Chiara, Ricci, Silvia, Lodi, Lorenzo, Quinti, Isabella, Milito, Cinzia, Leonardi, Lucia, Duse, Marzia, Carrabba, Maria, Fabio, Giovanna, Bertolini, Patrizia, Coccia, Paola, D’Alba, Irene, Pession, Andrea, Conti, Francesca, Zecca, Marco, Lunardi, Claudio, Bianco, Manuela Lo, Presti, Santiago, Sciuto, Laura, Micheli, Roberto, Bruzzese, Dario, Lougaris, Vassilios, Badolato, Raffaele, Plebani, Alessandro, Chessa, Luciana, and Pignata, Claudio

Published
2022
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17. Laparoscopic gynecological surgery under minimally invasive anesthesia: a prospective cohort study.

Author

Giampaolino, Pierluigi, primary, Mercorio, Antonio, additional, Corte, Luigi Della, additional, Bruzzese, Dario, additional, Coviello, Antonio, additional, Grasso, Giovanna, additional, Piano, Anna Claudia Del, additional, Candice, Agostino, additional, Sardo, Attilio Di Spiezio, additional, Servillo, Giuseppe, additional, and Bifulco, Giuseppe, additional

Published
2024
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18. Isolated Valve Amyloid Deposition in Aortic Stenosis: Potential Clinical and Pathophysiological Relevance

Author

Conte, Maddalena, primary, Poggio, Paolo, additional, Monti, Maria, additional, Petraglia, Laura, additional, Cabaro, Serena, additional, Bruzzese, Dario, additional, Comentale, Giuseppe, additional, Caruso, Aurelio, additional, Grimaldi, Mariagabriella, additional, Zampella, Emilia, additional, Gencarelli, Annarita, additional, Cervasio, Maria Rosaria, additional, Cozzolino, Flora, additional, Monaco, Vittoria, additional, Myasoedova, Veronika, additional, Valerio, Vincenza, additional, Ferro, Adele, additional, Insabato, Luigi, additional, Bellino, Michele, additional, Galasso, Gennaro, additional, Graziani, Francesca, additional, Pucci, Pietro, additional, Formisano, Pietro, additional, Pilato, Emanuele, additional, Cuocolo, Alberto, additional, Perrone Filardi, Pasquale, additional, Leosco, Dario, additional, and Parisi, Valentina, additional

Published
2024
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21. Assessment of Total, PTEN–, and AR-V7+ Circulating Tumor Cell Count by Flow Cytometry in Patients with Metastatic Castration-Resistant Prostate Cancer Receiving Enzalutamide

Author

Di Lorenzo, Giuseppe, Zappavigna, Silvia, Crocetto, Felice, Giuliano, Mario, Ribera, Dario, Morra, Rocco, Scafuri, Luca, Verde, Antonio, Bruzzese, Dario, Iaccarino, Simona, Costabile, Ferdinando, Onofrio, Livia, Viggiani, Martina, Palmieri, Alessandro, De Placido, Pietro, Marretta, Antonella Lucia, Pietroluongo, Erica, Luce, Amalia, Abate, Marianna, Navaeiseddighi, Zahrasadat, Caputo, Vincenzo Francesco, Celentano, Giuseppe, Longo, Nicola, Ferro, Matteo, Morelli, Franco, Facchini, Gaetano, Caraglia, Michele, De Placido, Sabino, and Buonerba, Carlo

Published
2021
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27. Findings from the Use of Spinal Anesthesia in the Laparoscopic Treatment of Extrauterine Pregnancy: Could It Represent an Alternative to General Anesthesia?

Author

Della Corte, Luigi, primary, Guarino, Maria Chiara, additional, Dell'Aquila, Michela, additional, Ascione, Mario, additional, Guerra, Serena, additional, De Rosa, Rossella, additional, Del Piano, Annaclaudia, additional, Bruzzese, Dario, additional, Bifulco, Giuseppe, additional, and Giampaolino, Pierluigi, additional

Published
2023
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28. Impact of vasodilators on diuretic response in patients with congestive heart failure: a mechanistic trial of cimlanod (BMS‐986231)

Author

Pellicori, Pierpaolo, primary, Cleland, John G.F., additional, Borentain, Maria, additional, Taubel, Jorg, additional, Graham, Fraser, additional, Khan, Javed, additional, Bruzzese, Dario, additional, Kessler, Paul, additional, McMurray, John J.V., additional, Voors, Adriaan A., additional, O'Connor, Christopher M., additional, Teerlink, John R., additional, and Felker, G. Michael, additional

Published
2023
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35. Findings from the Use of Spinal Anesthesia in the Laparoscopic Treatment of Extrauterine Pregnancy: Could It Represent an Alternative to General Anesthesia?

Author

Della Corte, Luigi, Guarino, Maria Chiara, Dell'Aquila, Michela, Ascione, Mario, Guerra, Serena, De Rosa, Rossella, Del Piano, Annaclaudia, Bruzzese, Dario, Bifulco, Giuseppe, and Giampaolino, Pierluigi

Subjects
ECTOPIC pregnancy, SALPINGECTOMY, SPINAL anesthesia, GENERAL anesthesia, MINIMALLY invasive procedures, LAPAROSCOPIC surgery
Abstract

Introduction: Minimally invasive procedures performed in laparoscopy, such as salpingectomy for ectopic pregnancy, can be combined with a minimally invasive anesthesia. The aim of this study was to assess the feasibility and the intraoperative and postoperative outcomes of laparoscopic surgery for ectopic pregnancy under spinal anesthesia (SA) compared to general anesthesia (GA) from the point of view of the surgeon, anesthesiologist, and patient. Methods: A retrospective cohort study was performed at DAI Materno Infantile of AOU Federico II of Naples, analyzing all medical records of women who met the inclusion criteria between April 2020 and April 2023. Eighty-two women (35 under SA in group A and 47 under GA in group B) undergone elective or emergency laparoscopic salpingectomy for ectopic tubal or ovarian pregnancy were included. Results: Patients in group A reported less pain at 0 h (adjusted mean difference: −1.5; 95% CI: −2.3 to −0.7; p < 0.001) and after 6 h (adjusted mean difference: −1.1; 95% CI: −2.0 to −0.3; p = 0.01) while no statistically significant differences between the two groups at 12 and 24 h after surgery. No differences were observed among the type of analgesic and during the postoperative observation time, except for paracetamol at 0 h in group B. A faster resumption of bowel motility, patient's mobilization, and a shorter hospital stay were observed in group A compared to group B. Also greater odds of returning faster to daily activities emerged in group A (adjusted OR: 5.39; 95% CI: 1.77–16.37). A greater number of patients in group A were satisfied with the entire procedure compared to those of group B (33 [94.3%] vs. 37 [78.7%]). The general surgeon satisfaction was always very good or excellent in group A. Finally, all surgical steps were well tolerated in group A. Conclusion: In specific settings, SA is a feasible and safe procedure for the laparoscopic treatment of ectopic pregnancy. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Impact of vasodilators on diuretic response in patients with congestive heart failure: A mechanistic trial of cimlanod (BMS‐986231).

Author

Pellicori, Pierpaolo, Cleland, John G.F., Borentain, Maria, Taubel, Jorg, Graham, Fraser J., Khan, Javed, Bruzzese, Dario, Kessler, Paul, McMurray, John J.V., Voors, Adriaan A., O'Connor, Christopher M., Teerlink, John R., and Felker, G. Michael

Subjects
FUROSEMIDE, BRAIN natriuretic factor, CONGESTIVE heart failure, HEART failure patients, SYSTOLIC blood pressure, DIURETICS
Abstract

Aim: To investigate the effects of Cimlanod, a nitroxyl donor with vasodilator properties, on water and salt excretion after an administration of an intravenos bolus of furosemide. Methods and results: In this randomized, double‐blind, mechanistic, crossover trial, 21 patients with left ventricular ejection fraction <45%, increased plasma concentrations of N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) and receiving loop diuretics were given, on separate study days, either an 8 h intravenous (IV) infusion of cimlanod (12 μg/kg/min) or placebo. Furosemide was given as a 40 mg IV bolus four hours after the start of infusion. The primary endpoint was urine volume in the 4 h after the bolus of furosemide during infusion of cimlanod compared with placebo. Median NT‐proBNP at baseline was 1487 (interquartile range: 847–2665) ng/L. Infusion of cimlanod increased cardiac output and reduced blood pressure without affecting cardiac power index consistent with its vasodilator effects. Urine volume in the 4 h post‐furosemide was lower with cimlanod (1032 ± 393 ml) versus placebo (1481 ± 560 ml) (p = 0.002), as were total sodium excretion (p = 0.004), fractional sodium excretion (p = 0.016), systolic blood pressure (p < 0.001), estimated glomerular filtration rate (p = 0.012), and haemoglobin (p = 0.010), an index of plasma volume expansion. Conclusions: For patients with heart failure and congestion, vasodilatation with agents such as cimlanod reduces the response to diuretic agents, which may offset any benefit from acute reductions in cardiac preload and afterload. [ABSTRACT FROM AUTHOR]

Published
2024
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38. Prevalence of Functional Gastrointestinal Disorders in Children and Adolescents in the Mediterranean Region of Europe

Author

Kafritsa, Panayota, Brusa, Sandra, Campanozzi, Angelo, Romano, Claudio, Salvatore, Silvia, Kotzakioulafi, Evelina, Barrio, Josefa, Cilleruelo, Maria Luz, Juste, Mercedes, Gutiérrez-Junquera, Carolina, Trbojević, Tena, Ivković, Lana, Scarpato, Elena, Kolacek, Sanja, Jojkic-Pavkov, Danijela, Konjik, Vlatka, Živković, Nataša, Roman, Enriqueta, Kostovski, Aco, Zdraveska, Nikolina, Altamimi, Eyad, Papadopoulou, Alexandra, Karagiozoglou-Lampoudi, Thomai, Shamir, Raanan, Bar Lev, Michal Rozenfeld, Koleilat, Aziz, Mneimneh, Sirin, Bruzzese, Dario, Leis, Rosaura, and Staiano, Annamaria

Published
2018
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39. Lack of efficacy of Lactobacillus GG in reducing pulmonary exacerbations and hospital admissions in children with cystic fibrosis: A randomised placebo controlled trial

Author

Bruzzese, Eugenia, Raia, Valeria, Ruberto, Eliana, Scotto, Riccardo, Giannattasio, Antonietta, Bruzzese, Dario, Cavicchi, Maria Cristina, Francalanci, Michela, Colombo, Carla, Faelli, Nadia, Daccò, Valeria, Magazzù, Giuseppe, Costa, Stefano, Lucidi, Vincenzina, Majo, Fabio, and Guarino, Alfredo

Published
2018
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40. Human epidermal growth factor receptor 2 dual blockade with trastuzumab and pertuzumab in real life: Italian clinical practice versus the CLEOPATRA trial results

Author

De Placido, Sabino, Giuliano, Mario, Schettini, Francesco, Von Arx, Claudia, Buono, Giuseppe, Riccardi, Ferdinando, Cianniello, Daniela, Caputo, Roberta, Puglisi, Fabio, Bonotto, Marta, Fabi, Alessandra, Bilancia, Domenico, Ciccarese, Mariangela, Lorusso, Vito, Michelotti, Andrea, Bruzzese, Dario, Veneziani, Bianca Maria, Locci, Mariavittoria, De Laurentiis, Michelino, and Arpino, Grazia

Published
2018
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42. Meta-Immunological Profiling of Children With Type 1 Diabetes Identifies New Biomarkers to Monitor Disease Progression

Author

Galgani, Mario, Nugnes, Rosa, Bruzzese, Dario, Perna, Francesco, De Rosa, Veronica, Procaccini, Claudio, Mozzillo, Enza, Cilio, Corrado M, Larsson, Helena Elding, Lernmark, Åke, La Cava, Antonio, Franzese, Adriana, and Matarese, Giuseppe

Subjects
Diabetes, Autoimmune Disease, Nutrition, Clinical Research, Pediatric, Detection, screening and diagnosis, 2.1 Biological and endogenous factors, 4.1 Discovery and preclinical testing of markers and technologies, Aetiology, Metabolic and endocrine, Autoimmunity, Biomarkers, Child, Diabetes Mellitus, Type 1, Disease Progression, Flow Cytometry, Humans, Insulin-Secreting Cells, Monitoring, Immunologic, Prognosis, T-Lymphocytes, Medical and Health Sciences, Endocrinology & Metabolism
Abstract

Type 1 diabetes is characterized by autoimmune destruction of pancreatic β-cells in genetically susceptible individuals. Triggers of islet autoimmunity, time course, and the precise mechanisms responsible for the progressive β-cell failure are not completely understood. The recent escalation of obesity in affluent countries has been suggested to contribute to the increased incidence of type 1 diabetes. Understanding the link between metabolism and immune tolerance could lead to the identification of new markers for the monitoring of disease onset and progression. We studied several immune cell subsets and factors with high metabolic impact as markers associated with disease progression in high-risk subjects and type 1 diabetic patients at onset and at 12 and 24 months after diagnosis. A multiple correlation matrix among different parameters was evaluated statistically and assessed visually on two-dimensional graphs. Markers to predict residual β-cell function up to 1 year after diagnosis were identified in multivariate logistic regression models. The meta-immunological profile changed significantly over time in patients, and a specific signature that was associated with worsening disease was identified. A multivariate logistic regression model measuring age, BMI, fasting C-peptide, number of circulating CD3(+)CD16(+)CD56(+) cells, and the percentage of CD1c(+)CD19(-)CD14(-)CD303(-) type 1 myeloid dendritic cells at disease onset had a significant predictive value. The identification of a specific meta-immunological profile associated with disease status may contribute to our understanding of the basis of diabetes progression.

Published
2013

43. Incidence of fatigue and low-dose corticosteroid use in prostate cancer patients receiving systemic treatment: a meta-analysis of randomized controlled trials

Author

Ferro, Matteo, Di Lorenzo, Giuseppe, de Cobelli, Ottavio, Bruzzese, Dario, Pignataro, Piero, Borghesi, Marco, Musi, Gennaro, Vartolomei, Mihai Dorin, Cosimato, Vincenzo, Serino, Alessandro, Ieluzzi, Vincenzo, Terracciano, Daniela, Damiano, Rocco, Cantiello, Francesco, Mistretta, Francesco Alessandro, Muto, Matteo, Lucarelli, Giuseppe, De Placido, Pietro, and Buonerba, Carlo

Published
2019
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47. Prevalence and Risk Factors of Functional Gastrointestinal Disorders: A Cross-Sectional Study in Italian Infants and Young Children

Author

Scarpato, Elena, Salvatore, Silvia, Romano, Claudio, Bruzzese, Dario, Ferrara, Dante, Inferrera, Ramona, Zeevenhooven, Judith, Steutel, Nina F., Benninga, Marc A., Staiano, Annamaria, Scarpato, Elena, Salvatore, Silvia, Romano, Claudio, Bruzzese, Dario, Ferrara, Dante, Inferrera, Ramona, Zeevenhooven, Judith, Steutel, Nina F, Benninga, Marc A, Staiano, Annamaria, Paediatric Gastroenterology, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, and ARD - Amsterdam Reproduction and Development

Subjects
Rome IV criteria, Pediatrics, Perinatology and Child Health, Gastroenterology, Epidemiologic study, Constipation, Infant colic, Formula feeding
Abstract

Objectives: Reports of prevalence of functional gastrointestinal disorders (FGIDs) in infants/toddlers are widely variable. Reasons for this variability are not yet fully understood. The objective of this study is to estimate the prevalence of FGIDs according to Rome IV criteria and to evaluate associated factors, in Italian infants and toddlers. Methods: Subjects aged 0-48 months were enrolled by general pediatricians from 3 Italian regions. Parents or legal guardians were administered questionnaires including information about the child, the family, and GI symptoms according to Rome IV criteria. Results: Five hundred eight infants aged 0-12 months [mean age 4.4 ? 3.4 months; females (F) 40.9%], and 268 children aged 13-48 months (mean age 30.8 ? 10.7 months; F 44.4%) were included. In infants, prevalence of FGIDs was 21.1%, and the most prevalent FGID was infant colic (9.3%). In toddlers, prevalence of FGIDs was 19.6%, with functional constipation being the most frequent disorder (16.1%). In infants, multivariable analysis found that being older, being the only child, and living in a rural environment were associated with a lower rate of FGIDs. Prevalence was, in contrast, higher in infants fed with formula. Conclusions: One out of 5 Italian infants and young children is affected by at least 1 FGID. The most frequent FGID in infants is infant colic, while in toddlers this is functional constipation. In infants, prevalence of FGIDs is lower if the subject has no siblings, and in children living in a rural environment, while formula feeding represents a risk factor for FGIDs occurrence.

Published
2023

48. In severe obesity, subcutaneous adipose tissue cell-derived cytokines are early markers of impaired glucose tolerance and are modulated by quercetin

Author

D’Esposito, Vittoria, Ambrosio, Maria Rosaria, Liguoro, Domenico, Perruolo, Giuseppe, Lecce, Manuela, Cabaro, Serena, Aprile, Marianna, Marino, Ada, Pilone, Vincenzo, Forestieri, Pietro, Miele, Claudia, Bruzzese, Dario, Terracciano, Daniela, Beguinot, Francesco, and Formisano, Pietro

Abstract

Background: Excessive adiposity provides an inflammatory environment. However, in people with severe obesity, how systemic and local adipose tissue (AT)-derived cytokines contribute to worsening glucose tolerance is not clear. Methods: Ninty-two severely obese (SO) individuals undergoing bariatric surgery were enrolled and subjected to detailed clinical phenotyping. Following an oral glucose tolerance test, participants were included in three groups, based on the presence of normal glucose tolerance (NGT), impaired glucose tolerance (IGT), or type 2 diabetes (T2D). Serum and subcutaneous AT (SAT) biopsies were obtained and mesenchymal stem cells (MSCs) were isolated, characterized, and differentiated in adipocytes in vitro. TNFAand PPARGmRNA levels were determined by qRT-PCR. Circulating, adipocyte- and MSC-released cytokines, chemokines, and growth factors were assessed by multiplex ELISA. Results: Serum levels of IL-9, IL-13, and MIP-1β were increased in SO individuals with T2D, as compared with those with either IGT or NGT. At variance, SAT samples obtained from SO individuals with IGT displayed levels of TNFAwhich were threefold higher compared to those with NGT, but not different from those with T2D. Elevated levels of TNFα were also found in differentiated adipocytes, isolated from the SAT specimens of individuals with IGT and T2D, compared to those with NGT. Consistent with the pro-inflammatory milieu, IL-1β and IP-10 secretion was significantly higher in adipocytes from individuals with IGT and T2D. Moreover, increased levels of TNFα, both mRNA and secreted protein were detected in MSCs obtained from IGT and T2D, compared to NGT SO individuals. Exposure of T2D and IGT-derived MSCs to the anti-inflammatory flavonoid quercetin reduced TNFα levels and was paralleled by a significant decrease of the secretion of inflammatory cytokines. Conclusion: In severe obesity, enhanced SAT-derived inflammatory phenotype is an early step in the progression toward T2D and maybe, at least in part, attenuated by quercetin.

Published
2024
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49. Prognostic factors and outcome in anorexia nervosa: a follow-up study

Author

Errichiello, Luca, Iodice, Davide, Bruzzese, Dario, Gherghi, Marco, and Senatore, Ignazio

Abstract

Anorexia nervosa is an eating disorder characterized by food restriction, irrational fear of gaining weight and consequent weight loss. High mortality rates have been reported, mostly due to suicide and malnutrition. Good outcomes largely vary between 18 and 42 %. We aimed to assess outcome and prognostic factors of a large group of patients with anorexia nervosa. Moreover we aimed to identify clusters of prognostic factors related to specific outcomes. We retrospectively reviewed data of 100 patients diagnosed with anorexia nervosa previously hospitalized in a tertiary level structure. Then we performed follow-up structured telephone interviews. We identified four dead patients, while 34 % were clinically recovered. In univariate analysis, short duration of inpatient treatment (p= 0.003), short duration of disorder (p= 0.001), early age at first inpatient treatment (p= 0.025) and preserved insight (p= 0.029) were significantly associated with clinical recovery at follow-up. In multiple logistic regression analysis, duration of first inpatient treatment, duration of disorder and preserved insight maintained their association with outcome. Moreover multiple correspondence analysis and cluster analysis allowed to identify different typologies of patients with specific features. Notably, group 1 was characterized by two or more inpatient treatments, BMI ≤ 14, absence of insight, history of long-term inpatient treatments, first inpatient treatment ≥30 days. While group 4 was characterized by preserved insight, BMI ≥ 16, first inpatient treatment ≤14 days, no more than one inpatient treatment, no psychotropic drugs intake, duration of illness ≤4 years. We confirmed the association between short duration of inpatient treatment, short duration of disorder, early age at first inpatient treatment, preserved insight and clinical recovery. We also differentiated patients with anorexia nervosa in well-defined outcome groups according to specific clusters of prognostic factors. Our study might help clinicians to evaluate prognosis of patients with anorexia nervosa.

Published
2024
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50. Population Trends in Rates of Percutaneous Coronary Revascularization for Acute Coronary Syndromes Associated With the COVID-19 Outbreak

Author

Piccolo, Raffaele, Bruzzese, Dario, Mauro, Ciro, Aloia, Antonio, Baldi, Cesare, Boccalatte, Marco, Bottiglieri, Giuseppe, Briguori, Carlo, Caiazzo, Gianluca, Calabrò, Paolo, Cappelli-Bigazzi, Maurizio, De Simone, Ciro, Di Lorenzo, Emilio, Golino, Paolo, Monda, Vittorio, Perrotta, Rocco, Quaranta, Gaetano, Russolillo, Enrico, Scherillo, Marino, Tesorio, Tullio, Tuccillo, Bernardino, Valva, Giuseppe, Villari, Bruno, Tarantini, Giuseppe, Varricchio, Attilio, and Esposito, Giovanni

Published
2020
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