1. Relationship of SARS-CoV-2-specific CD4 response to COVID-19 severity and impact of HIV-1 and tuberculosis coinfection
- Author
-
Riou, Catherine, Bruyn, Elsa du, Stek, Cari, Daroowala, Remy, Goliath, Rene T., Abrahams, Fatima, Said-Hartley, Qonita, Allwood, Brian W., Hsiao, Nei-Yuan, Wilkinson, Katalin A., Arlehamn, Cecilia S. Lindestam, Sette, Alessandro, Wasserman, Sean, and Wilkinson, Robert J.
- Subjects
HIV (Viruses) -- Development and progression ,Comorbidity -- Development and progression ,Immune response -- Health aspects ,Tuberculosis -- Development and progression ,CD4 lymphocytes -- Health aspects ,Health care industry - Abstract
T cells are involved in control of coronavirus disease 2019 (COVID-19), but limited knowledge is available on the relationship between antigen-specific T cell response and disease severity. Here, we used flow cytometry to assess the magnitude, function, and phenotype of SARS coronavirus 2-specific (SARS-CoV-2-specific) [CD4.sup.+] T cells in 95 hospitalized COVID-19 patients, 38 of them being HIV-1 and/or tuberculosis (TB) coinfected, and 38 non-COVID-19 patients. We showed that SARS- CoV-2-specific [CD4.sup.+] T cell attributes, rather than magnitude, were associated with disease severity, with severe disease being characterized by poor polyfunctional potential, reduced proliferation capacity, and enhanced HLA-DR expression. Moreover, HIV-1 and TB coinfection skewed the SARS-CoV-2 T cell response. HIV-1-mediated [CD4.sup.+] T cell depletion associated with suboptimal T cell and humoral immune responses to SARS-CoV-2, and a decrease in the polyfunctional capacity of SARS-CoV- 2-specific [CD4.sup.+] T cells was observed in COVID-19 patients with active TB. Our results also revealed that COVID-19 patients displayed reduced frequency of Mycobacterium tuberculosis-specific [CD4.sup.+] T cells, with possible implications for TB disease progression. These results corroborate the important role of SARS-CoV-2-specific T cells in COVID-19 pathogenesis and support the concept of altered T cell functions in patients with severe disease., Introduction Coronavirus disease 2019 (COVID-19), caused by SARS coronavirus 2 (SARS-CoV-2), emerged in December 2019 and is the cause of a devastating pandemic resulting in more than 100 million infections [...]
- Published
- 2021
- Full Text
- View/download PDF