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5. Personalizing Cancer Pain Therapy: Insights from the Rational Use of Analgesics (RUA) Group

Author

Varrassi, G., Coluzzi, F., Guardamagna, V. A., Puntillo, F., Sotgiu, G., Vellucci, R., Abrardi, L., Aiello, A., Albanese, G. V., Alongi, A., Altavilla, L., Ambrosio, R., Ammirati, L. A., Bacchini, G. P., Balbi, V., Ballarin, S., Balloni, A. G., Bambagioni, V., Bellavia, G., Berte', R., Bertolini, F., Bertolucci, A., Bilani, V., Bonafede, E. V., Bonato, C., Bondi, F., Bosco, M., Bottino, F., Branca, B., Brizio, A., Brogi, L., Brollo, M., Bruera, G., Brusco, G., Burato, A. M., Caiozzi, S. F., Calabrese, G., Calligaris, M., Cantisani, E., Capecchi, S., Caponi, S., Carbone, M., Carella, C., Careri, M. C., Carnicella, A., Caruso, M. L., Catania, E., Cavo, A., Cianci, G., Cocchiarella, A., Colombo, L., Corsi, G., Cortinovis, R., Costantini, S., Crispi, M., Cuccu, G., Cuomo, A., Dalia, P., D'Amato, G., De Chirico, C., De Clementi, M., De Gasperi, M., De Lisi, A., De Lucia, L., De Martino, G., De Toni, P., De Tursi, M., Defendi, S., Degl'Innocenti, M., Santi, I. D., Destro, M., Di Bartolomeo, C., Di Ciaula, G., Di Fonzo, C., Di Maggio, G., Di Matteo, S., Di Paolo, A., Di Trapani, M. C., Di Zio, I., Diodati, M., Dongiovanni, D., D'Urso, M., Fabiani, M. G., Facciuto, P., Falco, V., Faraone, E., Fasano, M., Ferrara, P., Florian, C., Fora, G., Fornaro, F., Forno, B., Fortis, M., Foti, S., Friolo, D., Gabris, A., Galanti, D., Galizia, B., Gallo, P., Gaudio, L., Gentili, G., Ginex, G., Giuliani, J., Gobber, G., Amerelli, A. G., Gorgni, S., Gucciardino, C., Ieri, T., Ingui', M., Jamara, G., La Sala, A., Lattuca, P., Mauro, M. L., Luigini, A., Luisi, D., Lungu, V., Mabilia, R., Macaluso, S., Maglio, A., Magnapera, A., Maione, A., Malorgio, F., Mancuso, A., Manni, A., Marchesi, R., Mariani, M., Martini, A., Massetti, M., Mauceri, M., Melo, M., Merlotti, R., Modugno, D., Montagna, M. C., Montanari, L., Napolitano, G., Nicodemo, M., Orlandini, G., Orlandini, F., Orsi, P., Pacifico, C., Pagliaro, E., Paladini, A., Paolucci, V., Pascazio, A., Pastore, A., Patanella, I., Pedaci, E., Pellegrini, A., Pellerito, N., Pepe, V., Petreni, P., Piazza, S., Picchi, M., Piccinelli, G., Pignatelli, A., Pinta, F., Pinto, T., Piovano, P. L., Pirajno, G., Pollastrini, C., Potenza, I., Provenzano, A., Provinciali, N., Puglia, L., Putignano, D., Ranucci, A., Ravoni, G., Redivo, L., Ricchini, F., Rizzi, F., Romoli, M., Ronga, G., Rosafio, I., Roselli, L., Russano, M., Russo, P., Saetta, A., Sarnelli, R., Sartori, S., Saviola, A., Scandone, F., Scibilia, C., Silverj, E., Sosta, E., Sparacino, M. E., Tavella, E., Tempera, S., Terranova, A., Tomasini, V., Trivellato, E., Vallisneri, C., Vannini, A., Vassillo, M., Verni, P., Visconti, E., Zaza, A., and Zizzetti, S.

Subjects
medicine.medical_specialty, Palliative care, business.industry, Pain medicine, Breakthrough pain, Cancer pain, Opioid-induced bowel dysfunction (OIBD), Opioid-induced constipation (OIC), Opioids, Delphi method, Likert scale, Anesthesiology and Pain Medicine, Opioid, Multidisciplinary approach, Interquartile range, Family medicine, Medicine, Neurology (clinical), business, medicine.drug
Abstract

A previous Delphi survey from the Rational Use of Analgesics (RUA) project involving Italian palliative care specialists revealed some discrepancies between current guidelines and clinical practice with a lack of consensus on items regarding the use of strong opioids in treating cancer pain. Those results represented the basis for a new Delphi study addressing a better approach to pain treatment in patients with cancer. The study consisted of a two-round multidisciplinary Delphi study. Specialists rated their agreement with a set of 17 statements using a 5-point Likert scale (0 = totally disagree and 4 = totally agree). Consensus on a statement was achieved if the median consensus score (MCS) (expressed as value at which at least 50% of participants agreed) was at least 4 and the interquartile range (IQR) was 3–4. This survey included input from 186 palliative care specialists representing all Italian territory. Consensus was reached on seven statements. More than 70% of participants agreed with the use of low dose of strong opioids in moderate pain treatment and valued transdermal route as an effective option when the oral route is not available. There was strong consensus on the importance of knowing opioid pharmacokinetics for therapy personalization and on identifying immediate-release opioids as key for tailoring therapy to patients’ needs. Limited agreement was reached on items regarding breakthrough pain and the management of opioid-induced bowel dysfunction. These findings may assist clinicians in applying clinical evidence to routine care settings and call for a reappraisal of current pain treatment recommendations with the final aim of optimizing the clinical use of strong opioids in patients with cancer.

Published
2021

19. Tissue Transglutaminase Antibodies in Celiac Disease

Author

Harold Ellis, J Y Yiannakou, P M Smith, Gino Roberto Corazza, Brusco G, Gillian L Swift, Paul J. Ciclitira, and Federico Biagi

Subjects
Adult, Male, Pathology, medicine.medical_specialty, Adolescent, Tissue transglutaminase, Biopsy, Population, Enzyme-Linked Immunosorbent Assay, Pilot Projects, Immunofluorescence, Sensitivity and Specificity, Coeliac disease, Serology, Antigen, Immunopathology, medicine, Animals, Humans, Intestinal Mucosa, education, Aged, Autoantibodies, education.field_of_study, Transglutaminases, Hepatology, medicine.diagnostic_test, biology, business.industry, Gastroenterology, Middle Aged, medicine.disease, Immunoglobulin A, Celiac Disease, Cats, biology.protein, Female, business
Abstract

OBJECTIVE: Tissue transglutaminase is the antigen for antiendomysial antibodies, whose power in screening for celiac disease is well known. Our aim was to assess the efficacy of an ELISA assay for tissue transglutaminase antibodies. METHODS: Tissue transglutaminase antibodies were analyzed in serum from 39 untreated celiac disease patients and 61 controls. Tissue transglutaminase was used as antigen, and test sera analyzed by ELISA. Results higher than 0.6 optical density were considered positive, lower than 0.4 negative, and between 0.4 and 0.6 borderline. RESULTS: Optical density of the serum from the patients with untreated celiac disease (median: 1.41; range: 0.33–1.47) were significantly higher than the controls (median: 0.32; range: 0.17–0.68; p < 0.0001; 95% confidence interval 0.87–1.08). Thirty-three patients with untreated celiac disease were positive, 4 borderline, and 2 negative. Fifty-five controls were negative, 4 borderline, and 2 positive. If we consider borderline results to be positive, sensitivity is 94.8% and specificity 90.1%. None of the controls gave results higher than 0.7 optical density. Apart from the 2 negative patients with untreated celiac disease, the two groups overlapped only between 0.4 and 0.7 optical density. CONCLUSIONS: Because of the high sensitivity (≈95%) and technical simplicity, tissue transglutaminase antibodies may prove useful for the screening of celiac disease in population at low or medium risk of celiac disease. To avoid duodenal biopsies in patients without celiac disease, the specificity of the screening procedure may be increased by confirming with antiendomysial antibodies by immunofluorescence on human umbilical cord in individuals with results between 0.4 and 0.7 optical density.

Published
1999

23. [Assessment of androgenic decline in the elderly]

Author

Claudia, Campusano M, Francisca, Brusco G, Carmen, Campino J, Luis, Rodríguez P, and Eugenio, Arteaga U

Subjects
Male, Aging, Estradiol, Hypogonadism, Radioimmunoassay, Middle Aged, Models, Biological, Case-Control Studies, Sex Hormone-Binding Globulin, Androgens, Humans, Testosterone, Chile, Aged
Abstract

The gold standard to assess androgenic status is the measurement of free testosterone by equilibrium dialysis. However, the estimation of free testosterone using formulas based on the law of mass action can be an adequate standard.To assess androgenic decline in the elderly by different methods.Free testosterone by radioimmunoassay, total testosterone and steroid binding globulin (SHBG) by automated chemiluminiscence system and estradiol by automated electrochemiluminiscence system were measured in 30 male aged 64+/-5 years (range 60-70), and 25 males aged between 20 and 30 years, as control group; devoid of diseases or drugs that could cause hypogonadism. Free androgen index, free testosterone, biavailable testosterone, and free estradiol were calculated using a formula based on the law of mass action.Fifty seven percent of elderly subjects had hypogonadism, according to calculated free testosterone values. Their total testosterone was on average, 152 nd/dl lower than in young adults, figure that represents a 3.8 ng/dl decline per year. According to total testosterone values, 27% of elderly males had gonadal incompetence. The correlations between calculated free testosterone and total testosterone was 0,95 and between calculated free testosterone and measured free testosterone was 0,67. The methods employed overestimated (76.7% of hypogonadism when using the free androgen index) or underestimated (27 and 3% of hypogonadism, considering total or free testosterone, respectively) the ondrogen decline of the elderly. Among the elderly, 16 or 30% of subjects had an absolute hypoestrogenism, based on estradiol or calculated free estradiol values, respectively. On average there was a 20 and 30% reduction of estradiol and calculated free estradiol values in the elderly.Calculated free or bioavailable testosterone values should be used to assess androgen decline in elderly men.

Published
2006

24. Comparación de distintos métodos para evaluar la función androgénica en el adulto mayor

Author

Luis Rodríguez P, Claudia Campusano M, Eugenio Arteaga U, Carmen Campino J, and Francisca Brusco G

Subjects
medicine.medical_specialty, biology, Free testosterone, business.industry, Free androgen index, Hypogonadism, medicine.medical_treatment, Hypoestrogenism, Testosterone (patch), Radioimmunoassay, General Medicine, medicine.disease, Steroid, Endocrinology, Sex hormone-binding globulin, Internal medicine, Free estradiol, Androgens, medicine, biology.protein, business, Aged
Abstract

Background:The gold standard to assess androgenic status is the measurement of free testosterone by equilibrium dialysis. However, the estimation of free testosterone using formulas based on the law of mass action can be an adequate standard. Aim: To assess androgenic decline in the elderly by different methods. Material and methods: Free testosterone by radioimmunoassay, total testosterone and steroid binding globulin (SHBG) by automated chemiluminiscence system and estradiol by automated electrochemiluminiscence system were measured in 30 male aged 64±5 years (range 60-70), and 25 males aged between 20 and 30 years, as control group; devoid of diseases or drugs that could cause hypogonadism. Free androgen index, free testosterone, biavailable testosterone, and free estradiol were calculated using a formula based on the law of mass action. Results: Fifty seven percent of elderly subjects had hypogonadism, according to calculated free testosterone values. Their total testosterone was on average, 152 nd/dl lower than in young adults, figure that represents a 3.8 ng/dl decline per year. According to total testosterone values, 27% of elderly males had gonadal incompetence. The correlations between calculated free testosterone and total testosterone was 0,95 and between calculated free testosterone and measured free testosterone was 0,67. The methods employed overestimated (76.7% of hypogonadism when using the free androgen index) or underestimated (27 and 3% of hypogonadism, considering total or free testosterone, respectively) the ondrogen decline of the elderly. Among the elderly, 16 or 30% of subjects had an absolute hypoestrogenism, based on estradiol or calculated free estradiol values, respectively. On average there was a 20 and 30% reduction of estradiol and calculated free estradiol values in the elderly. Conclusions: Calculated free or bioavailable testosterone values should be used to assess androgen decline in elderly men

Published
2006

25. Comparación de distintos métodos para evaluar la función androgénica en el adulto mayor

Author

Campusano M, Claudia, Brusco G, Francisca, Campino J, Carmen, Rodríguez P, Luis, and Arteaga U, Eugenio

Subjects
Hypogonadism, Androgens, Aged
Abstract

Background:The gold standard to assess androgenic status is the measurement of free testosterone by equilibrium dialysis. However, the estimation of free testosterone using formulas based on the law of mass action can be an adequate standard. Aim: To assess androgenic decline in the elderly by different methods. Material and methods: Free testosterone by radioimmunoassay, total testosterone and steroid binding globulin (SHBG) by automated chemiluminiscence system and estradiol by automated electrochemiluminiscence system were measured in 30 male aged 64±5 years (range 60-70), and 25 males aged between 20 and 30 years, as control group; devoid of diseases or drugs that could cause hypogonadism. Free androgen index, free testosterone, biavailable testosterone, and free estradiol were calculated using a formula based on the law of mass action. Results: Fifty seven percent of elderly subjects had hypogonadism, according to calculated free testosterone values. Their total testosterone was on average, 152 nd/dl lower than in young adults, figure that represents a 3.8 ng/dl decline per year. According to total testosterone values, 27% of elderly males had gonadal incompetence. The correlations between calculated free testosterone and total testosterone was 0,95 and between calculated free testosterone and measured free testosterone was 0,67. The methods employed overestimated (76.7% of hypogonadism when using the free androgen index) or underestimated (27 and 3% of hypogonadism, considering total or free testosterone, respectively) the ondrogen decline of the elderly. Among the elderly, 16 or 30% of subjects had an absolute hypoestrogenism, based on estradiol or calculated free estradiol values, respectively. On average there was a 20 and 30% reduction of estradiol and calculated free estradiol values in the elderly. Conclusions: Calculated free or bioavailable testosterone values should be used to assess androgen decline in elderly men

Published
2006

26. A Laboratory-Scale Prototype of a Smart User Network with DBS Control.

Author

Menniti, D., Sorrentino, N., Pinnarelli, A., Brusco, G., Barone, G., Motta, M., and Burgio, A.

Subjects
DIRECT currents, ELECTRICAL energy, RENEWABLE energy sources, MICROGRIDS, ELECTRIC power distribution grids
Abstract

The paper presents the experimental results of a research project focus on the development of smart DC microgrids for residential applications. A single-phase laboratory-scale prototype of a DC microgrid, named by the authors Smart User Network, is illustrated in details. It is realized in the Laboratory of Electrical Energy Systems and Renewable Energy of University of Calabria. It can represent several type of users, such as consumers, producers and so-called prosumers (producer and consumer at the same time). For highly efficient integration, several type of micro sources, storage systems and loads are connected to the same DC bus and interfaced to LV grid via appropriate power converters. The power management of the Smart User Network is based on the DC bus signaling control logic to guarantee safe operation both in grid-connected that in stand-alone mode, as proposed by the authors in a previous paper. A technical description of the laboratory-scale prototype components and of the control concepts are reported. Experimental results from the operation of the laboratory-scale prototype demonstrates the validity of the DBS as decentralized control for DC microgrid highlighting all the necessary steps to shift the technology from laboratory-scale to real industry. [ABSTRACT FROM AUTHOR]

Published
2017
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29. Enfermedad de Paget en Chile: una serie de 15 pacientes

Author

Eugenio Arteaga U, Loreto Massardo, Francisca Brusco G, Oscar Contreras O, Gilberto González, Sergio Jacobelli G, José Adolfo Rodríguez P, and Cristián Ortiz M

Subjects
medicine.medical_specialty, Pediatrics, business.industry, Paget disease, extramammary, General Medicine, Osteoarthritis, medicine.disease, Surgery, Bone remodeling, medicine.anatomical_structure, Osteitis deformans, Radiological weapon, Alkaline phosphatase, medicine, Deformity, Femur, medicine.symptom, First-degree relatives, Bone pain, business, Pelvis
Abstract

Background: Paget disease of bone (PD) is a localized disorder of bone remodeling, which leads to bone fragility and deformity. In Chile PD is uncommon. Aim: To study clinical and demographic characteristics of patients with PD seen in the Clinical Hospital of the Catholic University. Patients and methods: Patients with typical radiological and clinical features of PD referred to our institution during the last decade were included in this review. Results: We obtained data from 15 patients with PD (ten males, eight Chilean, six European and one Asian), eleven of them were diagnosed during the last 3 years. The mean age at diagnosis was 68,7±11,1 years old. No one had first degree relatives with PD. Bone pain was the main complaint in 13 patients and elevated total alkaline phosphatases in the other two. The average duration of the symptoms prior to diagnosis was 38,8 months. Eight patients had monostotic lesions; the most commonly involved sites were the pelvis, spine and femur. Radiological evaluation disclosed sclerotic changes in all patients as well as bone deformity and osteoarthritis in eight patients. Total alkaline phosphatases were elevated in 14 cases (mean: 4 times over the upper normal limit). Conclusions: When compared to series of the Northern hemisphere, PD in Chile is characterized by an older age at diagnosis, a higher frequency of symptomatic presentation, advanced radiological involvement and greater proportion of complications. PD should be suspected in every patient, Chilean or foreigner, with bone pain or elevated alkaline phosphatases (Rev Med Chile 2003; 131: 491-7).

Published
2003

36. Mortality in patients with coeliac disease and their relatives: a cohort study

Author

Corrao, G, Corazza, G, Bagnardi, V, Brusco, G, Ciacci, C, Cottone, M, Sategna Guidetti, C, Usai, P, Cesari, P, Pelli, M, Loperfido, S, Volta, U, Calabró, A, Certo, M, CORRAO, GIOVANNI, BAGNARDI, VINCENZO, Corazza, GR, Pelli, MA, Certo, M., Corrao, G, Corazza, G, Bagnardi, V, Brusco, G, Ciacci, C, Cottone, M, Sategna Guidetti, C, Usai, P, Cesari, P, Pelli, M, Loperfido, S, Volta, U, Calabró, A, Certo, M, CORRAO, GIOVANNI, BAGNARDI, VINCENZO, Corazza, GR, Pelli, MA, and Certo, M.

Abstract

BACKGROUND: Although previous studies have shown increased mortality in patients with coeliac disease and their relatives, no data are available in relation to different patterns of clinical presentation. We assessed mortality in patients with coeliac disease and their first-degree relatives. METHODS: We enrolled, in a prospective cohort study, 1072 adult patients with coeliac disease consecutively diagnosed in 11 gastroenterology units between 1962 and 1994, and their 3384 first-degree relatives. We compared the number of deaths up to 1998 with expected deaths and expressed the comparison as standardised mortality ratio (SMR) and relative survival ratio. FINDINGS: 53 coeliac patients died compared with 25.9 expected deaths (SMR 2.0 [95% CI 1.5-2.7]). A significant excess of mortality was evident during the first 3 years after diagnosis of coeliac disease and in patients who presented with malabsorption symptoms (2.5 [1.8-3.4]), but not in those diagnosed because of minor symptoms (1.1 [0.5-2.2]) or because of antibody screening (1.2 [0.1-7.0]). SMR increased with increasing delay in diagnosis and for patients with poor compliance with gluten-free diet. Non-Hodgkin lymphoma was the main cause of death. No excess of deaths was recorded in relatives with coeliac disease. INTERPRETATION: Prompt and strict dietary treatment decreases mortality in coeliac patients. Prospective studies are needed to clarify the progression of mild or symptomless coeliac disease and its relation to intestinal lymphoma.

Published
2001

39. About the Effectiveness, the Electric Demand Profile Impact and the Imbalance Reduction of an Optimal Sized CHP Generator for an Agro-Industrial Microgrid Using Real Data.

Author

Brusco, G., Burgio, A., Menniti, D., Pinnarelli, A., and Sorrentino, N.

Subjects
ELECTRIC generators, ELECTRIC equipment, ELECTRIC machinery, ELECTRIC power production, ELECTRICAL engineering
Abstract

In a previous paper the authors optimally sized a combined heat and power distributed generator for an agro-industrial microgrid using expected demand profiles; in this paper, the effectiveness of such a generator is further investigated using measured demand profiles. A number of comparison are performed, including the calculation of the economic benefits, the evaluation of the impact of the generator by the grid point of view and the calculation of the imbalance reduction. [ABSTRACT FROM AUTHOR]

Published
2015
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43. Enfermedad de Paget en Chile: una serie de 15 pacientes

Author

González V, Gilberto, primary, Brusco G, Francisca, additional, Arteaga U, Eugenio, additional, Rodríguez P, José, additional, Jacobelli G, Sergio, additional, Massardo V, Loreto, additional, Ortiz M, Cristián, additional, and Contreras O, Oscar, additional

Published
2003
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44. A Power Management and Control Strategy with Grid-Ancillary Services for a Microgrid Based on DC Bus.

Author

Barone, G., Brusco, G., Burgio, A., Menniti, D., Pinnarelli, A., and Sorrentino, N.

Subjects
BUSES, DIRECT currents, ELECTRIC potential, SMART power grids, ELECTRIC power distribution grids
Abstract

The deployment of distributed generation into the existing passive distribution networks is reaching a critical point whereby it can no longer be installed in the typical "fit and forget" fashion without influencing network operation and stability. The operating practice of distribution networks will need to change from a passive to an active role. In this context, in the paper a power management control strategy with grid-ancillary services for a novel configuration of a microgrid, defined by the authors as a Smart User Network, characterized by different types of micro-sources and storage systems interconnected by a common DC bus, is proposed. Several numerical results have been performed using a model of Smart User Network implemented in Matlab/Simulink environment and the most significant ones are illustrated and discussed. [ABSTRACT FROM AUTHOR]

Published
2014

49. Inositol: effects on oocyte quality in patients undergoing ICSI. An open study.

Author

BRUSCO, G. and MARIANI, M.

Abstract

OBJECTIVES: Nuclear and cytoplasmic competence of human oocyte is critical for future competence of the embryo upon which ultimately depends the outcome of an ART (Assisted Reproductive Technology) treatment. Follicular microenvironment in which the oocyte develops is crucial, and this must be taken into account particularly with the use of hormonal ovarian stimulation protocols. Inositol is an important element of the follicular environment and data support that its higher level in follicular fluid correlates with the development of a good oocyte. Aim of this study is to understand the effects of treatment with inositol on oocyte quality in a sample of patients undergoing ICSI (Intracytoplasmic Sperm Injection). PATIENTS AND METHODS: Assessment of oocyte/embryo quality and pregnancy rates in 149 patients divided, according to a controlled randomized pattern, into two groups: study group 1 treated with folic acid and inositol and control group 2 treated with folic acid alone. RESULTS: The number of patients with excellent and good oocyte quality appears to be significantly higher in group 1 (p = 0.02), as shown, they significantly increased the number of embryos of grade A transferred in the group 1 (p = 0.02) compared to group 2, despite being completely similar averages of total embryos transferred (total mean ± SD = 2.4 ± 0.8, group 1 mean ± SD = 2.4 ± 0.8, group 2 mean ± SD = 2.4 ± 0.8). There is not any significant difference between groups 1 and 2 in the number of positivity to β-hCG and in the number of biochemical pregnancies detected although it has a tendency to increase in the first and to decrease in the second for group 1. The increase in percentage of clinical pregnancies in group 1 was statistically significant (p = 0.02), whereas there was no apparent significance in the difference between the biochemical and clinical pregnancies in the two groups despite the positive trend in the study group. CONCLUSIONS: Relying on "Inositol help" to solidify our efforts, seems to be an easy path to help to deepen the effectiveness of its use in all patients still under 40 but with prior failed attempts at ICSI or diagnosed with PCOS or as "poor responders". [ABSTRACT FROM AUTHOR]

Published
2013

50. A Self Adaptive Fuzzy Logic MPPT Controller Based on Genetic Algorithm.

Author

Menniti, D., Pinnarelli, A., Sorrentino, N., Brusco, G., and Burgio, A.

Subjects
MAXIMUM power point trackers, COMBINATORIAL optimization, FUZZY systems, GENETIC algorithms, MATHEMATICAL logic
Abstract

A photovoltaic generator needs to be controlled in order to extract the maximum power from the primary energy source nonlinearly depending on the atmospheric operating conditions. For years, research has focused on various maximum power point tracking algorithms to draw the maximum power of the solar array and many methods have been proposed in literature; the most famous and easiest to implement are the "Perturb & Observe" method (P&O) and the "Incremental Conductance" (InCo) method. One of the computational methods, which have demonstrated good performance under different atmospheric operating conditions, is the maximum power point tracking technique based on fuzzy logic, which gives better converge speed and improves the tracking performance with minimum oscillation. Asits performance mainly depends on the domain of input and output fuzzy variables, this paper proposes a Genetic algorithm to automatically choose such domains. Its performance has been evaluated simulating it on a grid connected photovoltaic generation system implemented in a Matlab/Simulink environment. The simulation results show that the proposed maximum power point tracking controller is more efficient than conventional ones when the photovoltaic system is subjected to variations in atmospheric operating conditions. [ABSTRACT FROM AUTHOR]

Published
2013
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