23 results on '"Bruschieri L"'
Search Results
2. Back to (new) normality—A CODRAL/AIRO-L survey on cancer radiotherapy in Lombardy during Italian COVID-19 phase 2
- Author
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Jereczek-Fossa, B, Pepa, M, Marvaso, G, Isaksson, J, Soatti, C, Cazzaniga, L, Ivaldi, G, Amadori, M, Antognoni, P, Arcangeli, S, Buffoli, A, Beltramo, G, Bignardi, M, Bracelli, S, Bruschieri, L, Castiglioni, S, Catalano, G, Di Muzio, N, Fallai, C, Fariselli, L, Filippi, A, Gramaglia, A, Italia, C, Lombardi, F, Magrini, S, Nava, S, Orlandi, E, Pasinetti, N, Sbicego, E, Scandolaro, L, Scorsetti, M, Stiglich, F, Tortini, R, Valdagni, R, Vavassori, V, Tonoli, S, Palazzi, M, Jereczek-Fossa B. A., Pepa M., Marvaso G., Isaksson J. L., Soatti C. P., Cazzaniga L. F., Ivaldi G. B., Amadori M., Antognoni P., Arcangeli S., Buffoli A., Beltramo G., Bignardi M., Bracelli S., Bruschieri L., Castiglioni S., Catalano G., Di Muzio N., Fallai C., Fariselli L., Filippi A. R., Gramaglia A., Italia C., Lombardi F., Magrini S. M., Nava S., Orlandi E., Pasinetti N., Sbicego E. L., Scandolaro L., Scorsetti M., Stiglich F., Tortini R., Valdagni R., Vavassori V., Tonoli S., Palazzi M. F., Jereczek-Fossa, B, Pepa, M, Marvaso, G, Isaksson, J, Soatti, C, Cazzaniga, L, Ivaldi, G, Amadori, M, Antognoni, P, Arcangeli, S, Buffoli, A, Beltramo, G, Bignardi, M, Bracelli, S, Bruschieri, L, Castiglioni, S, Catalano, G, Di Muzio, N, Fallai, C, Fariselli, L, Filippi, A, Gramaglia, A, Italia, C, Lombardi, F, Magrini, S, Nava, S, Orlandi, E, Pasinetti, N, Sbicego, E, Scandolaro, L, Scorsetti, M, Stiglich, F, Tortini, R, Valdagni, R, Vavassori, V, Tonoli, S, Palazzi, M, Jereczek-Fossa B. A., Pepa M., Marvaso G., Isaksson J. L., Soatti C. P., Cazzaniga L. F., Ivaldi G. B., Amadori M., Antognoni P., Arcangeli S., Buffoli A., Beltramo G., Bignardi M., Bracelli S., Bruschieri L., Castiglioni S., Catalano G., Di Muzio N., Fallai C., Fariselli L., Filippi A. R., Gramaglia A., Italia C., Lombardi F., Magrini S. M., Nava S., Orlandi E., Pasinetti N., Sbicego E. L., Scandolaro L., Scorsetti M., Stiglich F., Tortini R., Valdagni R., Vavassori V., Tonoli S., and Palazzi M. F.
- Abstract
Background: Italy experienced one of the world’s severest COVID-19 outbreak, with Lombardy being the most afflicted region. However, the imposed safety measures allowed to flatten the epidemic curve and hence to ease the restrictions and inaugurate, on the 4th of May 2020, the Italian phase (P) 2 of the pandemic. The present survey study, endorsed by CODRAL and AIRO-L, aimed to assess how radiotherapy (RT) departments in Lombardy have dealt with the recovery. Materials and methods: A questionnaire dealing with the management of pandemic was developed online and sent to all CODRAL Directors on the 10th of June 2020. Answers were collected in full anonymity one week after. Results: All the 33 contacted RT facilities (100%) responded to the survey. Despite the scale of the pandemic, during P1 14 (42.4%) centres managed to safely continue the activity (≤ 10% reduction). During P2, 10 (30.3%) centres fully recovered and 14 (42.4%) reported an increase. Nonetheless, 6 (18.2%) declared no changes and, interestingly, 3 (9.1%) reduced activities. Overall, 21 centres (63.6%) reported suspected or positive cases within healthcare workforce since the beginning of the pandemic. Staff units were quarantined in 19 (57.6%) and 6 (18.2%) centres throughout P1 and P2, respectively. In the two phases, about two thirds centres registered positive or suspected cases amongst patients. Conclusion: The study revealed a particular attention to anti-contagion measures and a return to normal or even higher clinical workload in most RT centres in Lombardy, necessary to carry out current and previously deferred treatments.
- Published
- 2020
3. COVID-19 Outbreak and Cancer Radiotherapy Disruption in Lombardy, Northern Italy
- Author
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Jereczek-Fossa, B, Palazzi, M, Soatti, C, Cazzaniga, L, Ivaldi, G, Pepa, M, Amadori, M, Antognoni, P, Arcangeli, S, Buffoli, A, Beltramo, G, Berlinghieri, S, Bignardi, M, Bracelli, S, Bruschieri, L, Castiglioni, S, Catalano, G, Di Muzio, N, Fallai, C, Fariselli, L, Filippi, A, Gramaglia, A, Italia, C, Lombardi, F, Magrini, S, Nava, S, Orlandi, E, Pasinetti, N, Sbicego, E, Scandolaro, L, Scorsetti, M, Stiglich, F, Tonoli, S, Tortini, R, Valdagni, R, Vavassori, V, Marvaso, G, Jereczek-Fossa B. A., Palazzi M. F., Soatti C. P., Cazzaniga L. F., Ivaldi G. B., Pepa M., Amadori M., Antognoni P., Arcangeli S., Buffoli A., Beltramo G., Berlinghieri S., Bignardi M., Bracelli S., Bruschieri L., Castiglioni S., Catalano G., Di Muzio N., Fallai C., Fariselli L., Filippi A. R., Gramaglia A., Italia C., Lombardi F., Magrini S. M., Nava S., Orlandi E., Pasinetti N., Sbicego E. L., Scandolaro L., Scorsetti M., Stiglich F., Tonoli S., Tortini R., Valdagni R., Vavassori V., Marvaso G., Jereczek-Fossa, B, Palazzi, M, Soatti, C, Cazzaniga, L, Ivaldi, G, Pepa, M, Amadori, M, Antognoni, P, Arcangeli, S, Buffoli, A, Beltramo, G, Berlinghieri, S, Bignardi, M, Bracelli, S, Bruschieri, L, Castiglioni, S, Catalano, G, Di Muzio, N, Fallai, C, Fariselli, L, Filippi, A, Gramaglia, A, Italia, C, Lombardi, F, Magrini, S, Nava, S, Orlandi, E, Pasinetti, N, Sbicego, E, Scandolaro, L, Scorsetti, M, Stiglich, F, Tonoli, S, Tortini, R, Valdagni, R, Vavassori, V, Marvaso, G, Jereczek-Fossa B. A., Palazzi M. F., Soatti C. P., Cazzaniga L. F., Ivaldi G. B., Pepa M., Amadori M., Antognoni P., Arcangeli S., Buffoli A., Beltramo G., Berlinghieri S., Bignardi M., Bracelli S., Bruschieri L., Castiglioni S., Catalano G., Di Muzio N., Fallai C., Fariselli L., Filippi A. R., Gramaglia A., Italia C., Lombardi F., Magrini S. M., Nava S., Orlandi E., Pasinetti N., Sbicego E. L., Scandolaro L., Scorsetti M., Stiglich F., Tonoli S., Tortini R., Valdagni R., Vavassori V., and Marvaso G.
- Published
- 2020
4. COVID-19 Outbreak and Cancer Radiotherapy Disruption in Lombardy, Northern Italy
- Author
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Jereczek-Fossa, B.A., primary, Palazzi, M.F., additional, Soatti, C.P., additional, Cazzaniga, L.F., additional, Ivaldi, G.B., additional, Pepa, M., additional, Amadori, M., additional, Antognoni, P., additional, Arcangeli, S., additional, Buffoli, A., additional, Beltramo, G., additional, Berlinghieri, S., additional, Bignardi, M., additional, Bracelli, S., additional, Bruschieri, L., additional, Castiglioni, S., additional, Catalano, G., additional, Di Muzio, N., additional, Fallai, C., additional, Fariselli, L., additional, Filippi, A.R., additional, Gramaglia, A., additional, Italia, C., additional, Lombardi, F., additional, Magrini, S.M., additional, Nava, S., additional, Orlandi, E., additional, Pasinetti, N., additional, Sbicego, E.L., additional, Scandolaro, L., additional, Scorsetti, M., additional, Stiglich, F., additional, Tonoli, S., additional, Tortini, R., additional, Valdagni, R., additional, Vavassori, V., additional, and Marvaso, G., additional
- Published
- 2020
- Full Text
- View/download PDF
5. Nasopharynxkarzinom in einem europäischen Gebiet mit geringer Inzidenz: Eine prospektive Beobachtungsanalyse der Kopf- und Hals-Studiengruppe der Italienischen Gesellschaft für Radioonkologie (AIRO)
- Author
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Tonoli, S, D'Alterio, Diana, Caspiani, O., Bacigalupo, Andrea, Bunkheila, F., Cianciulli, M., Merlotti, A., Podhradska, A., Rampino, M., Cante, D., Bruschieri, L., Gatta, Roberto, and Magrini, S. M.
- Subjects
Settore MED/15 - MALATTIE DEL SANGUE ,Radiotherapy ,Survival ,Toxicity ,Oncology ,Chemotherapy ,Prognosis ,Radiology, Nuclear Medicine and Imaging ,Nuclear Medicine and Imaging ,Radiology - Published
- 2016
6. Over the years change in prostate cancer management through the multidisciplinary team at a community hospital
- Author
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Coinu, A., primary, Petrelli, F., additional, Cabiddu, M., additional, Borgonovo, K., additional, Ghilardi, M., additional, Vavassori, I., additional, Milesi, R., additional, Taglialatela, D., additional, Hussein, Y., additional, Ceresoli, F., additional, Del Rosso, A., additional, Lisanti, R., additional, De Stefani, A., additional, Riboldi, V., additional, Vitali, E., additional, Bruschieri, L., additional, Sarti, E., additional, and Barni, S., additional
- Published
- 2016
- Full Text
- View/download PDF
7. Patterns of postoperative radiotherapy for head and neck cancer in Italy: a prospective, observational study by the Head and Neck group of the Italian Association for Radiation Oncology (AIRO)
- Author
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Palazzi, M., Alterio, D., Tonoli, S., Caspiatti, O., Bolner, A., Colombo, S., Dall’Oglio, S., Lastrucci, L., Bunkheila, F., Cianciulli, M., Ursino, Stefano, Bruschieri, L., Bacigalupo, A., Iannone, T., Barca, R., and Tomatis, S.
- Published
- 2011
8. Le controversie nella radioterapia adiuvante del carcinoma dell'endometrio
- Author
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Baio, A, Tiso, S, Tateo, S, Salamano, S, Mereu, L, Bruschieri, L, Cavallini Francolini, D, Corbella, F, De Vecchi, P, Squillace, L, and Franchini, P
- Published
- 2006
9. Nasopharynxkarzinom in einem europäischen Gebiet mit geringer Inzidenz : Eine prospektive Beobachtungsanalyse der Kopf- und Hals-Studiengruppe der Italienischen Gesellschaft für Radioonkologie (AIRO).
- Author
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Tonoli, S., Alterio, D., Caspiani, O., Bacigalupo, A., Bunkheila, F., Cianciulli, M., Merlotti, A., Podhradska, A., Rampino, M., Cante, D., Bruschieri, L., Gatta, R., Magrini, S., and Magrini, S M
- Subjects
CANCER relapse ,COMPARATIVE studies ,LONGITUDINAL method ,RESEARCH methodology ,MEDICAL cooperation ,NASOPHARYNX tumors ,PROGNOSIS ,RADIATION injuries ,RESEARCH ,SURVIVAL ,EVALUATION research ,TREATMENT effectiveness ,DISEASE incidence ,TUMOR treatment ,PREVENTION - Abstract
Copyright of Strahlentherapie und Onkologie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2016
- Full Text
- View/download PDF
10. C15 - Over the years change in prostate cancer management through the multidisciplinary team at a community hospital
- Author
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Coinu, A., Petrelli, F., Cabiddu, M., Borgonovo, K., Ghilardi, M., Vavassori, I., Milesi, R., Taglialatela, D., Hussein, Y., Ceresoli, F., Del Rosso, A., Lisanti, R., De Stefani, A., Riboldi, V., Vitali, E., Bruschieri, L., Sarti, E., and Barni, S.
- Published
- 2016
- Full Text
- View/download PDF
11. Changes in HDL-cholesterol and lipoprotein Lp(a) after 6-month treatment with finasteride in males affected by benign prostatic hyperplasia (BPH)
- Author
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Denti, L., Pasolini, G., Cortellini, P., Sanfelici, L., Benedetti, R., Cecchetti, A., Ferretti, S., Bruschieri, L., Ablondi, F., and Valenti, G.
- Published
- 2000
- Full Text
- View/download PDF
12. Back to (new) normality—A CODRAL/AIRO-L survey on cancer radiotherapy in Lombardy during Italian COVID-19 phase 2
- Author
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Stefano Bracelli, Giulia Marvaso, Matteo Pepa, Mauro Palazzi, Mario Bignardi, Marta Scorsetti, Barbara Alicja Jereczek-Fossa, Fabrizio Lombardi, Lorenza Bruschieri, S. Tonoli, Roberto Tortini, Nadia Di Muzio, Stefano Maria Magrini, L.F. Cazzaniga, C. Italia, Laura Fariselli, Luciano Scandolaro, Johannes Lars Isaksson, Nadia Pasinetti, Riccardo Valdagni, Francesco Stiglich, Carlo Pietro Soatti, Andrea Riccardo Filippi, Simonetta Nava, Elena Lara Sbicego, Stefano Arcangeli, Gianpiero Catalano, Carlo Fallai, Vittorio Vavassori, Alberto Buffoli, Paolo Antognoni, Ester Orlandi, M. Amadori, S. Castiglioni, Alberto Gramaglia, Giovanni Ivaldi, Giancarlo Beltramo, Jereczek-Fossa, B. A., Pepa, M., Marvaso, G., Isaksson, J. L., Soatti, C. P., Cazzaniga, L. F., Ivaldi, G. B., Amadori, M., Antognoni, P., Arcangeli, S., Buffoli, A., Beltramo, G., Bignardi, M., Bracelli, S., Bruschieri, L., Castiglioni, S., Catalano, G., Di Muzio, N., Fallai, C., Fariselli, L., Filippi, A. R., Gramaglia, A., Italia, C., Lombardi, F., Magrini, S. M., Nava, S., Orlandi, E., Pasinetti, N., Sbicego, E. L., Scandolaro, L., Scorsetti, M., Stiglich, F., Tortini, R., Valdagni, R., Vavassori, V., Tonoli, S., Palazzi, M. F., Jereczek-Fossa, B, Pepa, M, Marvaso, G, Isaksson, J, Soatti, C, Cazzaniga, L, Ivaldi, G, Amadori, M, Antognoni, P, Arcangeli, S, Buffoli, A, Beltramo, G, Bignardi, M, Bracelli, S, Bruschieri, L, Castiglioni, S, Catalano, G, Di Muzio, N, Fallai, C, Fariselli, L, Filippi, A, Gramaglia, A, Italia, C, Lombardi, F, Magrini, S, Nava, S, Orlandi, E, Pasinetti, N, Sbicego, E, Scandolaro, L, Scorsetti, M, Stiglich, F, Tortini, R, Valdagni, R, Vavassori, V, Tonoli, S, and Palazzi, M
- Subjects
Cancer Research ,medicine.medical_specialty ,Health Personnel ,Pneumonia, Viral ,Betacoronavirus ,03 medical and health sciences ,Patient safety ,0302 clinical medicine ,Ambulatory care ,Neoplasms ,Oncology Service, Hospital ,Surveys and Questionnaires ,Pandemic ,Humans ,Medicine ,Infection control ,Northern Italy ,Survey ,Pandemics ,Personal Protective Equipment ,Personal protective equipment ,Radiation oncologist ,Original Paper ,SARS-CoV-2 ,business.industry ,COVID-19 ,Outbreak ,Workload ,Hematology ,General Medicine ,Italy ,Oncology ,Cancer radiotherapy ,030220 oncology & carcinogenesis ,Family medicine ,Lombardy ,Coronavirus Infections ,business - Abstract
Background Italy experienced one of the world’s severest COVID-19 outbreak, with Lombardy being the most afflicted region. However, the imposed safety measures allowed to flatten the epidemic curve and hence to ease the restrictions and inaugurate, on the 4th of May 2020, the Italian phase (P) 2 of the pandemic. The present survey study, endorsed by CODRAL and AIRO-L, aimed to assess how radiotherapy (RT) departments in Lombardy have dealt with the recovery. Materials and methods A questionnaire dealing with the management of pandemic was developed online and sent to all CODRAL Directors on the 10th of June 2020. Answers were collected in full anonymity one week after. Results All the 33 contacted RT facilities (100%) responded to the survey. Despite the scale of the pandemic, during P1 14 (42.4%) centres managed to safely continue the activity (≤ 10% reduction). During P2, 10 (30.3%) centres fully recovered and 14 (42.4%) reported an increase. Nonetheless, 6 (18.2%) declared no changes and, interestingly, 3 (9.1%) reduced activities. Overall, 21 centres (63.6%) reported suspected or positive cases within healthcare workforce since the beginning of the pandemic. Staff units were quarantined in 19 (57.6%) and 6 (18.2%) centres throughout P1 and P2, respectively. In the two phases, about two thirds centres registered positive or suspected cases amongst patients. Conclusion The study revealed a particular attention to anti-contagion measures and a return to normal or even higher clinical workload in most RT centres in Lombardy, necessary to carry out current and previously deferred treatments. Electronic supplementary material The online version of this article (10.1007/s12032-020-01434-1) contains supplementary material, which is available to authorized users.
- Published
- 2020
13. COVID-19 Outbreak and Cancer Radiotherapy Disruption in Lombardy, Northern Italy
- Author
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Laura Fariselli, Barbara Alicja Jereczek-Fossa, C. Italia, Stefano Bracelli, M. Amadori, Gianpiero Catalano, L.F. Cazzaniga, Francesco Stiglich, Giancarlo Beltramo, S. Castiglioni, Fabrizio Lombardi, Giovanni Ivaldi, S. Tonoli, Roberto Tortini, Simonetta Nava, Stefano Arcangeli, Elena Lara Sbicego, Paolo Antognoni, Stefano Maria Magrini, Riccardo Valdagni, Giulia Marvaso, Luciano Scandolaro, Mario Bignardi, S. Berlinghieri, Lorenza Bruschieri, Ester Orlandi, A. Gramaglia, Nadia Pasinetti, Matteo Pepa, Marta Scorsetti, V. Vavassori, Alberto Buffoli, Andrea Riccardo Filippi, N. Di Muzio, Mauro Palazzi, Carlo Pietro Soatti, Carlo Fallai, Jereczek-Fossa, B, Palazzi, M, Soatti, C, Cazzaniga, L, Ivaldi, G, Pepa, M, Amadori, M, Antognoni, P, Arcangeli, S, Buffoli, A, Beltramo, G, Berlinghieri, S, Bignardi, M, Bracelli, S, Bruschieri, L, Castiglioni, S, Catalano, G, Di Muzio, N, Fallai, C, Fariselli, L, Filippi, A, Gramaglia, A, Italia, C, Lombardi, F, Magrini, S, Nava, S, Orlandi, E, Pasinetti, N, Sbicego, E, Scandolaro, L, Scorsetti, M, Stiglich, F, Tonoli, S, Tortini, R, Valdagni, R, Vavassori, V, Marvaso, G, Jereczek-Fossa, B. A., Palazzi, M. F., Soatti, C. P., Cazzaniga, L. F., Ivaldi, G. B., Pepa, M., Amadori, M., Antognoni, P., Arcangeli, S., Buffoli, A., Beltramo, G., Berlinghieri, S., Bignardi, M., Bracelli, S., Bruschieri, L., Castiglioni, S., Catalano, G., Di Muzio, N., Fallai, C., Fariselli, L., Filippi, A. R., Gramaglia, A., Italia, C., Lombardi, F., Magrini, S. M., Nava, S., Orlandi, E., Pasinetti, N., Sbicego, E. L., Scandolaro, L., Scorsetti, M., Stiglich, F., Tonoli, S., Tortini, R., Valdagni, R., Vavassori, V., and Marvaso, G.
- Subjects
2019-20 coronavirus outbreak ,Medical staff ,Infectious Disease Transmission, Patient-to-Professional ,Coronavirus disease 2019 (COVID-19) ,Pneumonia, Viral ,Betacoronavirus ,Environmental health ,Neoplasms ,Medicine ,Humans ,Covid-19, Radiotherapy ,Radiology, Nuclear Medicine and imaging ,Pandemics ,Infection Control ,business.industry ,SARS-CoV-2 ,Outbreak ,COVID-19 ,Northern italy ,Oncology ,Italy ,Radiology Nuclear Medicine and imaging ,Treatment interruption ,Cancer Radiotherapy ,Practice Guidelines as Topic ,business ,Coronavirus Infections - Published
- 2020
14. Radiotherapy for head and neck cancer in Lombardy: a survey by the Lombardy Group of the Italian Association for Radiation Oncology
- Author
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Anna Merlotti, Luca Marzoli, Paolo Antognoni, Ernestina Bianchi, Francesco Filippone, Nadia Di Muzio, Lorenza Bruschieri, Luigi De Cicco, Giovanni Ivaldi, S. Castiglioni, Roberto Orecchia, Merlotti, A, Di Muzio, N, Antognoni, P, Filippone, F, Bianchi, E, Castiglioni, S, Bruschieri, L, Ivaldi, G, De Cicco, L, Marzoli, L, and Orecchia, R.
- Subjects
Adult ,Male ,Cancer Research ,medicine.medical_specialty ,medicine.medical_treatment ,Hospitals, Private ,Radiation oncology ,Medicine ,Humans ,Medical physics ,Head and neck ,Aged ,Radiotherapy ,business.industry ,Hospitals, Public ,General surgery ,Head and neck cancer ,General Medicine ,Chemoradiotherapy ,Middle Aged ,medicine.disease ,Radiation therapy ,Oncology ,Italy ,Head and Neck Neoplasms ,Health Care Surveys ,Radiation Oncology ,Female ,Radiotherapy, Intensity-Modulated ,Radiotherapy, Conformal ,business ,Radiotherapy, Image-Guided - Abstract
Aims In 2013, a survey was conducted to analyze the available resources and their use in the radiation treatment of patients with malignancies of the head and neck region in Lombardy, on behalf of the Lombardy group of the Italian Association of Radiation Oncology. Methods A questionnaire was sent to 26 of 34 radiotherapy centers active in the region. Two centers were excluded because they did not treat head and neck cancers (Besta Neurological Institute and Cyberknife center), 4 had started their activity in 2013 or late 2012, and 2 satellite centers had their results included in the main center's response. Items investigated included number of patients with head and neck cancer treated in 2012, general technical issues, and integration with surgery and chemotherapy. Results Twenty-four questionnaires were returned (92% response rate). There was a good consistency on the use of radiotherapy in different settings, whereas integration with chemotherapy showed more heterogeneous data. Treatment techniques were 3D conformal radiotherapy or intensity-modulated radiotherapy with image-guided radiotherapy in most cases and a low rate of treatment-related death was observed. Conclusions This survey provides important data on the use of radiotherapy resources for patients with head and neck cancer in Lombardy. The data offer the opportunity to further investigate issues that could better standardize head and neck cancer treatment and allocate resources across the region.
- Published
- 2015
15. Steroids use and survival in patients with glioblastoma multiforme: a pooled analysis.
- Author
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Petrelli F, De Stefani A, Ghidini A, Bruschieri L, Riboldi V, Dottorini L, Iaculli A, Zaniboni A, and Trevisan F
- Subjects
- Adult, Chemoradiotherapy, Disease-Free Survival, Humans, Prospective Studies, Steroids therapeutic use, Temozolomide therapeutic use, Brain Neoplasms drug therapy, Glioblastoma drug therapy
- Abstract
Introduction: Steroids are commonly used for managing brain edema in patients with glioblastoma multiforme (GBM), treated with surgery and concomitant temozolomide-based chemoradiotherapy (CTRT). The adverse effects of glucocorticoids include lymphopenia, hyperglycemia, and risk of infection. We report the results of a meta-analysis evaluating the effects of steroids on outcome when associated with the treatment of GBM., Methods: PubMed, the Cochrane Library, and Embase were searched from inception until September 2019 for observational or prospective studies reporting prognosis of adult patients with GBM and treated or not treated with steroids. Overall survival (OS) was the primary endpoint, and progression-free survival (PFS) was the secondary endpoint. The effect size was reported as hazard ratios (HRs) with a 95% confidence interval (CI), and an HR > 1 associated with the worst outcome in steroid users compared to non-users., Results: Twenty-two publications were retrieved from studies selected for a total of 8,752 patients. In the primary analysis (n = 22 studies reporting data), OS was reduced in GBM patients taking steroids during treatment (HR = 1.54, 95% CI 1.37-1.75; p < 0.01). Similarly, PFS was inferior in steroid users in n = 9 studies with data available (HR = 1.28, 95% CI 1.1-1.49; p < 0.01)., Conclusions: In patients with GBM and treated with RT and/or CT, association with steroids significantly reduces survival and PFS. Use of the lowest dose of glucocorticoids for the shortest period needed to achieve the treatment goals and prevention of steroid-associated complications are essential aims of treatment of this disease.
- Published
- 2021
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- View/download PDF
16. Back to (new) normality-A CODRAL/AIRO-L survey on cancer radiotherapy in Lombardy during Italian COVID-19 phase 2.
- Author
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Jereczek-Fossa BA, Pepa M, Marvaso G, Isaksson JL, Soatti CP, Cazzaniga LF, Ivaldi GB, Amadori M, Antognoni P, Arcangeli S, Buffoli A, Beltramo G, Bignardi M, Bracelli S, Bruschieri L, Castiglioni S, Catalano G, Di Muzio N, Fallai C, Fariselli L, Filippi AR, Gramaglia A, Italia C, Lombardi F, Magrini SM, Nava S, Orlandi E, Pasinetti N, Sbicego EL, Scandolaro L, Scorsetti M, Stiglich F, Tortini R, Valdagni R, Vavassori V, Tonoli S, and Palazzi MF
- Subjects
- COVID-19, Coronavirus Infections therapy, Health Personnel trends, Humans, Italy epidemiology, Pandemics, Personal Protective Equipment trends, Pneumonia, Viral therapy, SARS-CoV-2, Betacoronavirus, Coronavirus Infections epidemiology, Neoplasms epidemiology, Neoplasms radiotherapy, Oncology Service, Hospital trends, Pneumonia, Viral epidemiology, Surveys and Questionnaires
- Abstract
Background: Italy experienced one of the world's severest COVID-19 outbreak, with Lombardy being the most afflicted region. However, the imposed safety measures allowed to flatten the epidemic curve and hence to ease the restrictions and inaugurate, on the 4th of May 2020, the Italian phase (P) 2 of the pandemic. The present survey study, endorsed by CODRAL and AIRO-L, aimed to assess how radiotherapy (RT) departments in Lombardy have dealt with the recovery., Materials and Methods: A questionnaire dealing with the management of pandemic was developed online and sent to all CODRAL Directors on the 10th of June 2020. Answers were collected in full anonymity one week after., Results: All the 33 contacted RT facilities (100%) responded to the survey. Despite the scale of the pandemic, during P1 14 (42.4%) centres managed to safely continue the activity (≤ 10% reduction). During P2, 10 (30.3%) centres fully recovered and 14 (42.4%) reported an increase. Nonetheless, 6 (18.2%) declared no changes and, interestingly, 3 (9.1%) reduced activities. Overall, 21 centres (63.6%) reported suspected or positive cases within healthcare workforce since the beginning of the pandemic. Staff units were quarantined in 19 (57.6%) and 6 (18.2%) centres throughout P1 and P2, respectively. In the two phases, about two thirds centres registered positive or suspected cases amongst patients., Conclusion: The study revealed a particular attention to anti-contagion measures and a return to normal or even higher clinical workload in most RT centres in Lombardy, necessary to carry out current and previously deferred treatments.
- Published
- 2020
- Full Text
- View/download PDF
17. Total Neoadjuvant Therapy in Rectal Cancer: A Systematic Review and Meta-analysis of Treatment Outcomes.
- Author
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Petrelli F, Trevisan F, Cabiddu M, Sgroi G, Bruschieri L, Rausa E, Ghidini M, and Turati L
- Subjects
- Humans, Neoplasm Staging, Rectal Neoplasms mortality, Survival Rate, Chemoradiotherapy, Neoadjuvant Therapy, Outcome Assessment, Health Care, Rectal Neoplasms therapy
- Abstract
Background: The addition of induction chemotherapy to concomitant neoadjuvant chemoradiation in locally advanced rectal cancer could increase pathological downstaging and act on occult micrometastatic disease, leading ultimately to a better outcome. A systematic review was carried out of the existing literature on the treatment outcomes of total neoadjuvant therapy (TNT) on locally advanced rectal cancer. TNT was defined as chemotherapy using cycles of induction and/or consolidation in conjunction with standard chemoradiotherapy prior to surgery., Methods: A systematic search of PubMed, Embase, and the Cochrane Library was performed according to the PRISMA statement up until January 2019. The primary endpoints were complete pathologic response (pCR), disease-free survival, and overall survival rates., Results: A total of 28 studies (3 retrospective and 25 prospective for a total of 3579 patients) were included in the final analysis (n = 2688 treated with TNT and n = 891 with neoadjuvant chemoradiotherapy therapy). The pooled pCR rate was 22.4% (95% CI 19.4%-25.7%) in all patients treated with TNT (n = 27 studies with data available). In n = 10 comparative studies with data available, TNT was found to increase the odds of pCR by 39% (1.40, 95% CI 1.08-1.81, P = 0.01)., Conclusions: The addition of induction or consolidation chemotherapy to standard neoadjuvant chemoradiotherapy results in a higher pCR rate. Given that the comparative analysis was derived from few randomized publications, large confirmatory trials should be carried out before a strong recommendation is made in favor of TNT.
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- 2020
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18. Combination of radiotherapy and immunotherapy for brain metastases: A systematic review and meta-analysis.
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Petrelli F, De Stefani A, Trevisan F, Parati C, Inno A, Merelli B, Ghidini M, Bruschieri L, Vitali E, Cabiddu M, Borgonovo K, Ghilardi M, Barni S, and Ghidini A
- Subjects
- Humans, Immunotherapy, Melanoma, Neoplasms, Second Primary, Brain Neoplasms radiotherapy, Radioimmunotherapy
- Abstract
Radiotherapy (RT) represents a mainstay in the treatment of brain metastases (BMs) from solid tumors. Immunotherapy (IT) has improved survival of metastatic cancer patients across many tumor types. The combination of RT and IT for the treatment of BMs has a strong rationale, but data on efficacy and safety of this combination is still limited. A systematic search of PubMed, the Cochrane Central Register of Controlled Trials, and EMBASE was conducted. 33 studies were included for a total of 1520 patients, most of them with melanoma (87%). Median pooled OS was 15.9 months (95%CI 13.9-18.1). One- and 2-year OS rates were 55.2% (95% CI 49.3-60.9) and 35.7% (95% CI 30.4-41.3), respectively. Addition of IT to RT was associated with improved OS (HR = 0.54, 95%CI 0.44-0.67; P < 0.001). For patients with BMs from solid tumors, addition of concurrent IT to brain RT is able to increase survival and provide long term control., (Copyright © 2019 Elsevier B.V. All rights reserved.)
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- 2019
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19. Adjuvant radiotherapy for Merkel cell carcinoma: A systematic review and meta-analysis.
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Petrelli F, Ghidini A, Torchio M, Prinzi N, Trevisan F, Dallera P, De Stefani A, Russo A, Vitali E, Bruschieri L, Costanzo A, Seghezzi S, Ghidini M, Varricchio A, Cabiddu M, Barni S, de Braud F, and Pusceddu S
- Subjects
- Carcinoma, Merkel Cell pathology, Carcinoma, Merkel Cell surgery, Disease-Free Survival, Humans, Neoplasm Recurrence, Local, Prospective Studies, Radiotherapy, Adjuvant, Randomized Controlled Trials as Topic, Retrospective Studies, Skin Neoplasms pathology, Skin Neoplasms surgery, Carcinoma, Merkel Cell radiotherapy, Skin Neoplasms radiotherapy
- Abstract
Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous malignancy with a high propensity for local recurrence and regional and distant metastases. The main treatment is surgery with narrow excision margins and draining nodes, plus or minus adjuvant radiotherapy (RT) on the surgical bed and/or lymph nodes. We performed a systematic review and meta-analysis of the benefits of adjuvant RT in MCC treatment. PubMed, EMBASE, and the Cochrane Library were systematically searched to identify relevant studies published before September 2018. Prospective trials and retrospective series comparing adjuvant RT vs. no RT in resected primary MCCs were included. Primary endpoint was to evaluate the outcomes of MCC patients who received adjuvant RT in term of overall survival (OS) and disease-free survival (DFS). Hazard ratios (HRs) for OS and DFS were aggregated according to a fixed or random effect model. Secondary endpoints were local, locoregional, and distant DFS. A total of 17,179 MCCs across 29 studies were analysed. There was a significant difference in OS between the RT and no RT arms (HR = 0.81, 95%CI 0.75-0.86, P < 0.001). There was also a significant difference in DFS in favour of adjuvant RT (HR = 0.45, 95%CI 0.32-0.62, P < 0.001). Adjuvant RT improved locoregional DFS and local DFS but not distant DFS (HR = 0.3, 95%CI 0.22-0.42; HR = 0.21, 95%CI 0.14-0.33, and HR = 0.79, 95%CI 0.49-1.14, respectively). Meta-regression analysis showed that high Newcastle-Ottawa scale scores, stage I-II MCCs, shorter follow-up durations, size >2 cm, and being of a younger age were associated with increased OS. This systematic review and meta-analysis suggests a survival and DFS benefit for postoperative radiation of MCCs. Intermediate stage MCCs derive the maximum benefit with local and regional relapses reduced by 80% and 70%, respectively. Conversely, distant metastases were not significantly prevented., (Copyright © 2019 Elsevier B.V. All rights reserved.)
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- 2019
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20. Addition of radiotherapy to the primary tumour in oligometastatic NSCLC: A systematic review and meta-analysis.
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Petrelli F, Ghidini A, Cabiddu M, Tomasello G, De Stefani A, Bruschieri L, Vitali E, Ghilardi M, Borgonovo K, Barni S, and Trevisan F
- Subjects
- Carcinoma, Non-Small-Cell Lung pathology, Disease-Free Survival, Humans, Lung Neoplasms pathology, Neoplasm Metastasis, Neoplasm Staging, Outcome Assessment, Health Care, Carcinoma, Non-Small-Cell Lung radiotherapy, Lung Neoplasms radiotherapy
- Abstract
Oligometastatic non-small cell lung cancer (NSCLC) has a discrete number of distant lesions (<5) that can be amenable to radical treatment. The treatment of the primary lung tumour in such stage IV cases is still debated. We conducted a systematic review and meta-analysis to evaluate the outcome of these patients and the added benefit in terms of overall survival (OS) and progression-free survival (PFS) when radical treatment of the primary tumour with radiotherapy (RT) was delivered. PubMed, EMBASE and Cochrane Library were systematically searched to identify relevant studies published up to July 2018. Prospective trials and retrospective series comparing RT vs no RT to the primary NSCLC in the presence of oligometastases were included. Hazard ratios (HRs) for OS and PFS were aggregated according to a fixed or random effect model. Twenty-one studies for a total of 924 synchronous oligometastatic NSCLC were analysed. Median OS and PFS were 20.4 and 12 months. Pooled 1-2-3 and 5-year OS were 70.3%, 43.5%, 29.3% and 20.2% respectively. Overall survival was improved with the addition of thoracic RT (HR = 0.44, 95%CI 0.32-0.6; P < 0.001). Similarly, RT added to the primary tumour increased PFS (HR = 0.42, 95%CI 0.33-0.55; P < 0.001). The only variable associated with the median OS was the year of publication with most recent series associated with a better outcome. In patients with oligometastatic NSCLC and disease controlled with ablative therapy of distant metastases, a consolidation with radical RT to the primary tumour is associated with better survival and could be considered as a treatment modality in selected cases., (Copyright © 2018 Elsevier B.V. All rights reserved.)
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- 2018
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21. Radiotherapy for head and neck cancer in Lombardy: a survey by the Lombardy Group of the Italian Association for Radiation Oncology.
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Merlotti A, Di Muzio N, Antognoni P, Filippone F, Bianchi E, Castiglioni S, Bruschieri L, Ivaldi G, De Cicco L, Marzoli L, and Orecchia R
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- Adult, Aged, Chemoradiotherapy statistics & numerical data, Female, Head and Neck Neoplasms epidemiology, Health Care Surveys, Hospitals, Private statistics & numerical data, Hospitals, Public statistics & numerical data, Humans, Italy epidemiology, Male, Middle Aged, Radiotherapy statistics & numerical data, Radiotherapy, Conformal statistics & numerical data, Radiotherapy, Image-Guided statistics & numerical data, Radiotherapy, Intensity-Modulated statistics & numerical data, Head and Neck Neoplasms radiotherapy, Radiation Oncology statistics & numerical data
- Abstract
Aims: In 2013, a survey was conducted to analyze the available resources and their use in the radiation treatment of patients with malignancies of the head and neck region in Lombardy, on behalf of the Lombardy group of the Italian Association of Radiation Oncology., Methods: A questionnaire was sent to 26 of 34 radiotherapy centers active in the region. Two centers were excluded because they did not treat head and neck cancers (Besta Neurological Institute and Cyberknife center), 4 had started their activity in 2013 or late 2012, and 2 satellite centers had their results included in the main center's response. Items investigated included number of patients with head and neck cancer treated in 2012, general technical issues, and integration with surgery and chemotherapy., Results: Twenty-four questionnaires were returned (92% response rate). There was a good consistency on the use of radiotherapy in different settings, whereas integration with chemotherapy showed more heterogeneous data. Treatment techniques were 3D conformal radiotherapy or intensity-modulated radiotherapy with image-guided radiotherapy in most cases and a low rate of treatment-related death was observed., Conclusions: This survey provides important data on the use of radiotherapy resources for patients with head and neck cancer in Lombardy. The data offer the opportunity to further investigate issues that could better standardize head and neck cancer treatment and allocate resources across the region.
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- 2015
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22. Patterns of postoperative radiotherapy for head and neck cancer in Italy: a prospective, observational study by the head and neck group of the Italian Association for Radiation Oncology (AIRO).
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Palazzi M, Alterio D, Tonoli S, Caspiani O, Bolner A, Colombo S, Dall'oglio S, Lastrucci L, Bunkheila F, Cianciulli M, Vigna Taglianti R, Cante D, Merlotti A, Bianchi E, Rampino M, Podhradska A, Fontana A, Paiar F, Miccichè F, Manzo R, Ursino S, Bruschieri L, Bacigalupo A, Iannone T, Barca R, and Tomatis S
- Subjects
- Adult, Aged, Dose Fractionation, Radiation, Female, Head and Neck Neoplasms pathology, Humans, Italy, Male, Middle Aged, Neoplasm Invasiveness, Neoplasm Recurrence, Local radiotherapy, Neoplasm Staging, Neoplasm, Residual, Prospective Studies, Radiation Oncology, Radiotherapy Planning, Computer-Assisted, Radiotherapy, Adjuvant statistics & numerical data, Societies, Medical, Head and Neck Neoplasms radiotherapy, Head and Neck Neoplasms surgery
- Abstract
Aims and Background: Our previous survey showed that the patterns of postoperative radiotherapy (PORT) for head and neck cancer (HNC) in Italy might be suboptimal. A prospective observational study was therefore designed to evaluate this issue in greater detail., Methods: All radiotherapy centers involved in the HNC Working Group of the Italian Radiation Oncology Association were asked to enter into the study all patients treated with PORT during a 6-month period., Results: A total of 200 patients were accrued by 24 centers from December 2008 to May 2009. Larynx (38%) and oral cavity (34%) were the most common primary sites. The median time between surgery and the start of radiotherapy was 69 days (range, 25-215 days). Seventy-nine percent of cases with no evidence of risk factors for local recurrence were treated with high-dose radiotherapy to the primary site. In about 75% of cases the pN0 neck was included in the target volume. Concomitant chemotherapy was delivered to about 60% of patients with major risk factors and 21% of patients with no risk factors., Conclusions: Three issues emerged from our study as potential targets for future investigations: the impact on clinical outcome of the interval between surgery and the start of PORT; factors driving radiation oncologists to overtreat volumes at low risk of recurrence; and problems associated with the delivery of concomitant chemotherapy.
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- 2011
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23. The contribution of androgen decline to the aging-related changes of body composition and lipoprotein in the healthy man.
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Denti L, Pasolini G, Sanfelici L, Benedetti R, Cecchetti A, Bruschieri L, Ablondi F, and Valenti G
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- Adolescent, Adult, Aged, Aged, 80 and over, Aging blood, Body Constitution, Electric Impedance, Humans, Male, Middle Aged, Reference Values, Skinfold Thickness, Aging physiology, Androgens blood, Body Composition physiology, Lipoproteins blood
- Published
- 1999
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