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3. Notes Brèves et Prises de Position

Author

Armengaud, A., Boccassina, R., Brunschwig, H., Coquery-Vidrovitch, C., Debien, G., Flandrin, J.-L., Gritti, J., Saraiva, J.-A., Sigmann, J., and Souyri, P.

Published
1967

13. NOTES BIBLIOGRAPHIQUES

Author

Amalvi, Christian, Brunschwig, H., Pacaut, Marcel, Cloulas, Ivan, Musset, Lucien, Riché, Pierre, Pinoteau, Hervé, Joly, Bertrand, Guiral, Pierre, Bernas, Colette, Morineau, Michel, Verger, Jacques, Dalché, J. Gautier, Bennassar, Bartolomé, Deuve, Jean, Lafont, Pierre-Bernard, Imbert, Jean, and Weber, Edith

Published
1988

24. NOTES BIBLIOGRAPHIQUES

Author

Besnier, R., Schnerb, Robert, Meyer, A., Godechot, Jacques, Kayser, Jacques, Girard, Louis, Cloché, Paul, Brunschwig, H., Lévy, Roger, Haguenauer, Lapeyre, H., Vidalenc, J., Avezou, Robert, Girard, Louis, Néré, Jean, Perroy, E., de Saint-Jacob, P., Léonard, É. G., Égret, Jean, and Coquin, Fr.-X.

Published
1960

25. NOTES BIBLIOGRAPHIQUES

Author

Vigier, Ph., Besnier, R., Schnerb, Robert, Leclant, Jean, Godard, J., Guichonnet, Paul, Meyer, A., Brunschwig, Henri, Lestien, Général, Girard, Louis, Guiral, P., Gervais, Alice, Cloché, Paul, Brunschwig, H., Haguenauer, Delumeau, Jean, Reinhard, M., Guichonnet, Paul, and Néré, J.

Published
1960

26. NOTES BIBLIOGRAPHIQUES

Author

Perroy, E., Fohlen, Claude, Droz, Jacques, Crouzet, François, Meynier, André, Taton, R., Leclant, Jean, Cloché, Paul, Brunschwig, H., d'Hoop, Jean-Marie, Chesneaux, Jean, Defourneaux, M., Fauvel-Rouif, Denise, Égret, Jean, Phlipponneau, Michel, Vidalenc, Jean, Reinhard, M., Guichonnet, Paul, and Jobert, A.

Published
1961

27. NOTES BIBLIOGRAPHIQUES

Author

Bourgin, Georges, Néré, J., Schnerb, Robert, Perroy, E., Lussagnet, Suzanne, Cahen, Claude, Lambert, Maurice, Cloché, Paul, Lemerle, P., Brunschwig, H., Livet, Georges, Godard, J., Tapié, V.-L., and Gascon, R.

Published
1958

28. NOTES BIBLIOGRAPHIQUES

Author

Cloché, Paul, Cahen, Claude, Lestien, Brunschwig, H., Godard, J., Chauviré, Roger, Lapeyre, H., Vilar, Pierre, Mandrou, R., Giraud, M., Chesneaux, Jean, Meynier, A., Girard, Louis, Néré, J., Perroy, É., de Saint-Jacob, P., Filliozat, J., Delumeau, J., and Zeller, G.

Published
1956

30. NOTES BIBLIOGRAPHIQUES

Author

Bréhier, Louis, Meynier, André, Baumont, Maurice, Cloché, Paul, Lestien, Ricard, R., Droz, J., Brunschwig, H., Courtois, Christian, Gaillard, Georges, Fugier, A., Benda, C., Coornaert, E., and Godard, J.

Published
1948

31. NOTES BIBLIOGRAPHIQUES

Author

Crouzet, François, Bourgin, Georges, Marc-Bonnet, H., Baumont, Maurice, Lestien, Meynier, André, Schnerb, Robert, Gervais, Alice, Taton, René, Daux, Georges, Piganiol, André, Taylor, A. J. P., Brunschwig, H., Chaunu, Huguette, and Chaunu, Pierre

Published
1951

40. Fine-scale maps of recombination rates and hotspots in the mouse genome.

Author

Brunschwig H, Levi L, Ben-David E, Williams RW, Yakir B, and Shifman S

Subjects
Animals, Base Sequence, Evolution, Molecular, Female, Histone-Lysine N-Methyltransferase metabolism, Humans, Male, Mice, Nucleotide Motifs genetics, Promoter Regions, Genetic genetics, Species Specificity, Chromosome Mapping, Genome genetics, Recombination, Genetic genetics
Abstract

Recombination events are not uniformly distributed and often cluster in narrow regions known as recombination hotspots. Several studies using different approaches have dramatically advanced our understanding of recombination hotspot regulation. Population genetic data have been used to map and quantify hotspots in the human genome. Genetic variation in recombination rates and hotspots usage have been explored in human pedigrees, mouse intercrosses, and by sperm typing. These studies pointed to the central role of the PRDM9 gene in hotspot modulation. In this study, we used single nucleotide polymorphisms (SNPs) from whole-genome resequencing and genotyping studies of mouse inbred strains to estimate recombination rates across the mouse genome and identified 47,068 historical hotspots--an average of over 2477 per chromosome. We show by simulation that inbred mouse strains can be used to identify positions of historical hotspots. Recombination hotspots were found to be enriched for the predicted binding sequences for different alleles of the PRDM9 protein. Recombination rates were on average lower near transcription start sites (TSS). Comparing the inferred historical recombination hotspots with the recent genome-wide mapping of double-strand breaks (DSBs) in mouse sperm revealed a significant overlap, especially toward the telomeres. Our results suggest that inbred strains can be used to characterize and study the dynamics of historical recombination hotspots. They also strengthen previous findings on mouse recombination hotspots, and specifically the impact of sequence variants in Prdm9.

Published
2012
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41. Modeling attainment of steady state of drug concentration in plasma by means of a Bayesian approach using MCMC methods.

Author

Jordan P, Brunschwig H, and Luedin E

Subjects
Adult, Humans, Male, Markov Chains, Middle Aged, Monte Carlo Method, Nonlinear Dynamics, Bayes Theorem, Clinical Trials, Phase I as Topic statistics & numerical data, Data Interpretation, Statistical, Models, Biological, Models, Statistical, Pharmacokinetics, Randomized Controlled Trials as Topic statistics & numerical data, Research Design
Abstract

The approach of Bayesian mixed effects modeling is an appropriate method for estimating both population-specific as well as subject-specific times to steady state. In addition to pure estimation, the approach allows to determine the time until a certain fraction of individuals of a population has reached steady state with a pre-specified certainty. In this paper a mixed effects model for the parameters of a nonlinear pharmacokinetic model is used within a Bayesian framework. Model fitting by means of Markov Chain Monte Carlo methods as implemented in the Gibbs sampler as well as the extraction of estimates and probability statements of interest are described. Finally, the proposed approach is illustrated by application to trough data from a multiple dose clinical trial., ((c) 2007 John Wiley & Sons, Ltd.)

Published
2008
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42. [Children's rights in the family].

Author

Brunschwig H

Subjects
Child, Child, Preschool, Humans, Infant, Psychology, Child, Child Advocacy, Family, Interpersonal Relations
Published
1991

43. [Mother-child therapy].

Author

Brunschwig H

Subjects
Child, Preschool, Female, Humans, Psychology, Child, Psychosexual Development, Mother-Child Relations, Psychoanalytic Therapy methods
Published
1991

44. [Painful symbiosis].

Author

Brunschwig H

Subjects
Adult, Child, Child Behavior Disorders therapy, Female, Humans, Child Behavior Disorders psychology, Mother-Child Relations, Mothers psychology, Psychotherapy methods, Single Parent psychology
Published
1990

45. [Childhood fears].

Author

Brunschwig H

Subjects
Child, Child, Preschool, Humans, Infant, Infant, Newborn, Nursing Care, Parents education, Parents psychology, Fear, Psychology, Child
Published
1990

48. [Waiting for the baby].

Author

Brunschwig H

Subjects
Female, Humans, Interpersonal Relations, Male, Parent-Child Relations, Infant, Newborn, Parents psychology, Pregnancy
Published
1981

49. [Those girls who are not girls].

Author

Brunschwig H

Subjects
Adolescent, Adult, Female, Humans, Depression psychology, Mother-Child Relations
Published
1984

50. [Sexuality of the child and of the adolescent].

Author

Brunschwig H

Subjects
Adolescent, Child, Female, Humans, Latency Period, Psychological, Male, Sexual Maturation, Child Development, Psychology, Adolescent, Psychosexual Development
Published
1981

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