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1. Contents Vol. 81, 2008

Author

Claudio Panzironi, Faruk Gonenc, Daimantas Milonas, Stephen Wyler, Yasuhide Miyoshi, Klaus Kleinschmidt, C. Leonardo, C. Spiliopoulou, C. Van Audenhove, P.M. Braun, Bruno Guastella, Jun Ju, Yoshinobu Kubota, Soroush Rais-Bahrami, Pier-Luigi Degiorgis, K. Haustermans, Consolato Sergi, Wafaa Jamal, A. Alevizou, Hannes Steiner, Kazuhide Makiyama, Claudia Braun, Seung Choul Yang, F. Sofras, Giuseppe Mario Ludovico, Young Deuk Choi, A. Mariolis, K. De Ridder, Richard E. Hautmann, Luigi Cormio, Yi Rong Chen, Michael Mitterberger, Yusuf Ali, BaoGuang Shi, Nam Hoon Cho, Georg Bartsch, M. Soli, S. Junius, Sung Joon Hong, Joo Wan Seo, Mark Schrader, R. Sacco, Josef Oswald, A. Kumar, Wolf H. Weiske, Berkan Resorlu, Ahmed Magheli, Yuan Li, Amit Khandkar, A. Srivastava, Vincent O. Rotimi, J.R. Scheepe, Christian Radmayr, Viktoras Saferis, Elijah O. Kehinde, Takayuki Murakami, Ahmet Yazicioglu, Mesut Gürdal, A. Alevizos, R. Papalia, Apurva Chaudhary, Kadir Türkölmez, Carsten Kempkensteffen, Pritesh Srimali, Bjoern G. Volkmer, Sümer Baltaci, A. Loreto, Takeshi Watanabe, Yaşar Bedük, M. Gallucci, K. Bovis, Muzaffer Eroglu, N. Gupta, K.P. Jünemann, K. Stamatiou, Ege Can Serefoglu, Ikuo Miyagawa, Önder Kayıgil, Rainer Kuefer, Çağatay Göğüş, S. Isebaert, Kang Su Cho, Fathima Khodakhast, Roberto Ponchietti, Sumiyo Toji, Sung Yul Park, R. Coppola, Nesrin Turhan, F.S. Van Rey, Noboru Nakaigawa, P. Alken, Dong Soo Park, D. Desai, Ahmet Metin, S. Guaglianone, A. Athanasopoulos, H. Van Poppel, J.P.F.A. Heesakkers, Christian Gozzi, Mindaugas Jievaltas, Yogesh Bhandari, Jeong Yun Shim, Jürgen Zumbé, Bruno Giammusso, Mert Altinel, Emre Arpali, S. Joniau, Mohammed Seshah, Masahiro Yao, Nicolai Leonhartsberger, Giovanni M. Colpi, J. Simon, E.J. McGuire, Daniel Porres, Stefan Hinz, G. Simone, Ali Fuat Atmaca, Francesco Montorsi, V. Srinivas, Thomas Akkad, and Cemil Yagci

Subjects
Traditional medicine, business.industry, Urology, Medicine, business
Published
2008

2. Subject Index Vol. 81, 2008

Author

C. Van Audenhove, P.M. Braun, Jun Ju, Pier-Luigi Degiorgis, K. Haustermans, Mohammed Seshah, Kazuhide Makiyama, Masahiro Yao, Nicolai Leonhartsberger, Giovanni M. Colpi, J. Simon, E.J. McGuire, Viktoras Saferis, Elijah O. Kehinde, N. Gupta, Ali Fuat Atmaca, Takayuki Murakami, Yoshinobu Kubota, F. Sofras, Amit Khandkar, Hannes Steiner, Joo Wan Seo, Sung Joon Hong, K. De Ridder, A. Srivastava, J.P.F.A. Heesakkers, Claudio Panzironi, A. Alevizou, Faruk Gonenc, Christian Gozzi, Dong Soo Park, V. Srinivas, Ahmet Metin, Yuan Li, Yi Rong Chen, S. Isebaert, Thomas Akkad, Mesut Gürdal, Luigi Cormio, D. Desai, Nesrin Turhan, Josef Oswald, A. Kumar, Yusuf Ali, BaoGuang Shi, S. Guaglianone, Wolf H. Weiske, Stephen Wyler, Daimantas Milonas, Yasuhide Miyoshi, J.R. Scheepe, H. Van Poppel, Cemil Yagci, S. Junius, Mindaugas Jievaltas, A. Mariolis, Wafaa Jamal, Nam Hoon Cho, A. Alevizos, Önder Kayıgil, A. Athanasopoulos, Noboru Nakaigawa, C. Spiliopoulou, Bruno Guastella, Sümer Baltaci, A. Loreto, Bjoern G. Volkmer, Takeshi Watanabe, Ahmed Magheli, Roberto Ponchietti, Soroush Rais-Bahrami, Yogesh Bhandari, Michael Mitterberger, Sumiyo Toji, Rainer Kuefer, Jürgen Zumbé, Kang Su Cho, Francesco Montorsi, Giuseppe Mario Ludovico, M. Soli, Richard E. Hautmann, Sung Yul Park, Daniel Porres, Çağatay Göğüş, Stefan Hinz, Fathima Khodakhast, K. Bovis, R. Sacco, Vincent O. Rotimi, Jeong Yun Shim, M. Gallucci, G. Simone, Ahmet Yazicioglu, R. Coppola, S. Joniau, Bruno Giammusso, R. Papalia, Apurva Chaudhary, Kadir Türkölmez, F.S. Van Rey, Klaus Kleinschmidt, Mert Altinel, P. Alken, C. Leonardo, Muzaffer Eroglu, K.P. Jünemann, Emre Arpali, Mark Schrader, Georg Bartsch, Yaşar Bedük, Claudia Braun, Seung Choul Yang, Young Deuk Choi, K. Stamatiou, Berkan Resorlu, Christian Radmayr, Carsten Kempkensteffen, Pritesh Srimali, Ege Can Serefoglu, Ikuo Miyagawa, and Consolato Sergi

Subjects
medicine.medical_specialty, Index (economics), business.industry, Urology, General surgery, medicine, Subject (documents), business
Published
2008

3. An Open-Label, Randomized, Flexible-Dose, Crossover Study to Assess the Comparative Efficacy and Safety of Sildenafil Citrate and Apomorphine Hydrochloride in Men with Erectile Dysfunction

Author

Bruno Guastella, Claudio Panzironi, Giuseppe Mario Ludovico, Francesco Montorsi, Roberto Ponchietti, Luigi Cormio, Giovanni M. Colpi, Bruno Giammusso, M. Soli, Giammusso, Bruno, Colpi Giovanni, M., Cormio, Luigi, Ludovico, Giuseppe, Soli, Marcello, Ponchietti, Roberto, Montorsi, Francesco, Panzironi, Claudio, and Guastella, Bruno

Subjects
Adult, Male, Agonist, Time Factors, Apomorphine, medicine.drug_class, Sildenafil, Dopamine, Vasodilator Agents, Urology, Pharmacology, Piperazines, Sildenafil Citrate, law.invention, chemistry.chemical_compound, Erectile Dysfunction, Randomized controlled trial, law, Surveys and Questionnaires, medicine, Humans, apomorphine hydocloride, Sulfones, Apomorphine Hydrochloride, Cross-Over Studies, business.industry, Phosphodiesterase, erectile dysfunction, sildenafil citrate, Middle Aged, medicine.disease, Crossover study, respiratory tract diseases, Erectile dysfunction, chemistry, Purines, Research Design, cardiovascular system, Safety, business, medicine.drug
Abstract

Introduction: We report the methodology and results of a study that compared a dopaminergic agonist, apomorphine, with a phosphodiesterase type-5 inhibitor, sildenafil, in terms of efficacy, tolerability, satisfaction and patient preference. Patients and Methods: This was a 20-week open- label, randomized, flexible-dose, crossover study to assess the comparative efficacy and safety of sildenafil and apomorphine. One sequence group received treatment with sildenafil followed by apomorphine and the other sequence group received treatment with apomorphine followed by sildenafil. The primary efficacy variable was the measurement of the score of the erectile function domain (the sum of questions 1–5 and 15) of the International Index of Erectile Function (IIEF) questionnaire. The secondary efficacy variables were: the responses to the Global Efficacy Assessment Questions; the score of the responses to all the questions of the IIEF questionnaire; the index score of the Erectile Dysfunction Inventory of Treatment Satisfaction questionnaire, and the event log variables. Resultsand Conclusions: A marked increase in the mean IIEF score was observed after treatment with sildenafil, compared with a small increase following treatment with apomorphine. The mean baseline and final scores before and after treatment with sildenafil were 13.9 ± 5.2 and 24.1 ± 5.2, while the corresponding mean scores before and after treatment with apomorphine were 14.2 ± 5.1 and 16.8 ± 6.2. The comparison between treatments showed a statistically significant difference in favor of sildenafil. Furthermore, sildenafil was found to be significantly superior to apomorphine in all the other secondary variables, produced a high level of patient satisfaction, and a significantly larger number of patients indicated their preference for sildenafil compared to apomorphine.

Published
2008

4. Acknowledgement to the Reviewers

Author

Viktoras Saferis, Elijah O. Kehinde, Francesco Montorsi, Takayuki Murakami, Amit Khandkar, M. Gallucci, A. Srivastava, Daniel Porres, Muzaffer Eroglu, Stefan Hinz, Nesrin Turhan, Giuseppe Ludovico, C. Van Audenhove, P.M. Braun, G. Simone, Georg Bartsch, Luigi Cormio, Wolf H. Weiske, J.P.F.A. Heesakkers, Jun Ju, Yoshinobu Kubota, Christian Gozzi, Önder Kayıgil, Dong Soo Park, Takeshi Watanabe, Çağatay Göğüş, J.R. Scheepe, Berkan Resorlu, D. Desai, Nam Hoon Cho, Christian Radmayr, C. Leonardo, Noboru Nakaigawa, K. Haustermans, A. Alevizos, Ali Fuat Atmaca, K. Bovis, S. Junius, Mindaugas Jievaltas, Daimantas Milonas, Claudia Braun, Ahmet Metin, Seung Choul Yang, Bruno Giammusso, Mohammed Seshah, Mert Altinel, Young Deuk Choi, R. Coppola, Yi Rong Chen, Ahmed Magheli, Joo Wan Seo, Roberto Ponchietti, F.S. Van Rey, Emre Arpali, Mark Schrader, K. De Ridder, S. Guaglianone, Masahiro Yao, H. Van Poppel, Nicolai Leonhartsberger, Giovanni M. Colpi, E.J. McGuire, V. Srinivas, R. Papalia, P. Alken, A. Athanasopoulos, Yusuf Ali, BaoGuang Shi, Thomas Akkad, Kang Su Cho, Yogesh Bhandari, Wafaa Jamal, Carsten Kempkensteffen, Claudio Panzironi, Faruk Gonenc, Pier-Luigi Degiorgis, Cemil Yagci, Fathima Khodakhast, Kazuhide Makiyama, Jeong Yun Shim, S. Joniau, Pritesh Srimali, Yuan Li, Sumiyo Toji, Klaus Kleinschmidt, F. Sofras, Mesut Gürdal, Sung Yul Park, Rainer Kuefer, Yasuhide Miyoshi, Yaşar Bedük, Ege Can Serefoglu, Ikuo Miyagawa, Soroush Rais-Bahrami, N. Gupta, Hannes Steiner, Jürgen Zumbé, Richard E. Hautmann, S. Isebaert, Consolato Sergi, C. Spiliopoulou, Bruno Guastella, Bjoern G. Volkmer, K. Stamatiou, Josef Oswald, A. Kumar, Sümer Baltaci, A. Loreto, Michael Mitterberger, M. Soli, R. Sacco, Stephen Wyler, K.P. Jünemann, Sung Joon Hong, Vincent O. Rotimi, Ahmet Yazicioglu, Apurva Chaudhary, Kadir Türkölmez, A. Mariolis, A. Alevizou, and Joerg Simon

Subjects
Medical education, business.industry, Urology, Acknowledgement, Medicine, business
Published
2008

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