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1. Non HCV-related infectious cryoglobulinemia vasculitis: Results from the French nationwide CryoVas survey and systematic review of the literature

Author

Emmanuelle Plaisier, Bruno Graffin, Arnaud Hot, Luc de Saint-Martin, Catherine Michel, Patrice Cacoub, Patricia Senet, P. Belenotti, Olivier Hermine, Adeline Lacraz, Jean-Emmanuel Kahn, Benjamin Terrier, Xavier Mariette, Isabelle Marie, Jean-Marc Léger, Thomas Quemeneur, Fabrice Bonnet, Laurent Chiche, Service de médecine interne et centre de référence des maladies rares [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Médecine Interne [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Service de Néphrologie-Transplantation-Dialyse, CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin, Service de Médecine Interne (MARSEILLE - Med Int), Assistance Publique - Hôpitaux de Marseille (APHM), CHU Pontchaillou [Rennes], Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de Médecine Interne, Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Laboratoire d'Immunologie (EA 2686), Université de Lille, Droit et Santé, Physiologie des Adaptations Nutritionnelles (PhAN), Institut National de la Recherche Agronomique (INRA)-Université de Nantes (UN), CH Valenciennes, Département de Médecine Interne et Pneumologie [Brest] (DMIP - Brest), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), Université de Brest (UBO)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO), AB Science SA, Centre d'Immunologie et de Maladies Infectieuses (CIMI), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA), Service de Dermatologie [CHU Tenon], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Tenon [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université-Sorbonne Université, Service de Néphrologie et Dialyses [CHU Tenon], Immunologie - Immunopathologie - Immunothérapie (I3), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Cochin [AP-HP], Service de Médecine Interne [Rouen], Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), UMR 1280 Physiologie des Adaptations Nutritionnelles, Institut National de la Recherche Agronomique (INRA)-Université de Nantes (UN)-Alimentation Humaine (ALIM.H), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM)-Physiologie des Adaptations Nutritionnelles (PhAN), Université de Brest (UBO), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Tenon [APHP], Institut Cochin (IC UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Physiopathologie, Autoimmunité, maladies Neuromusculaires et THErapies Régénératrices (PANTHER), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Européen [Fondation Ambroise Paré - Marseille], Service de Médecine Interne [HI des Armées Legouest, Metz], Hôpital d’Instruction des Armées Legouest [Metz], Physiopathologie des Adaptations Nutritionnelles (PhAN), CHU Valenciennes, Service d'immuno-hématologie pédiatrique [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Service de Neurologie [CHU Pitié-Salpêtrière], IFR70-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Régulation de la réponse immune, infection VIH-1 et autoimmunité, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de dermatologie et allergologie [CHU Tenon], CHU Tenon [AP-HP], Remodelage et Reparation du Tissu Renal, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Physiologie des Adaptations Nutritionnelles [UMR_A1280] (PhAN), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Necker - Enfants Malades [AP-HP], Service de neurologie 1 [CHU Pitié-Salpétrière], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)

Subjects
Adult, Male, medicine.medical_specialty, Epstein-Barr Virus Infections, Hepatitis C virus, [SDV]Life Sciences [q-bio], Immunology, medicine.disease_cause, Anti-Infective Agents, Adrenal Cortex Hormones, Recurrence, Surveys and Questionnaires, medicine, Immunology and Allergy, Humans, Epstein–Barr virus infection, ComputingMilieux_MISCELLANEOUS, Aged, Hepatitis B virus, business.industry, Remission Induction, Systemic Vasculitis, Bacterial Infections, Hepatitis B, Middle Aged, medicine.disease, Prognosis, Cryoglobulinemia, Dermatology, 3. Good health, Treatment Outcome, Cytomegalovirus Infections, [SDV.IMM]Life Sciences [q-bio]/Immunology, Rituximab, Female, France, Vasculitis, business, Immunosuppressive Agents, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, medicine.drug, Systemic vasculitis
Abstract

In patients with infectious cryoglobulinemia vasculitis (CryoVas) in the absence of hepatitis C virus infection, data on presentation, therapeutic management and outcome are lacking. We conducted a nationwide survey that included patients with HCV-negative CryoVas. We describe here the presentation, therapeutic management and outcome of 18 patients with non-HCV infectious CryoVas and 27 additional patients identified form a systematic review of the literature. We included 18 patients, mean age 57.9±13.5 years. Infectious causes were viral infections in 8 patients [hepatitis B virus (HBV) in 4, and cytomegalovirus, Epstein Barr virus, parvovirus B19 and human immunodeficiency virus in one case each], pyogenic bacterial infection in 6 patients, parasitic infection in 2 patients, and leprosy and candidiasis in one case each. Baseline manifestations were purpura (78%), glomerulonephritis (28%), arthralgia (28%), peripheral neuropathy (22%), skin necrosis (22%), cutaneous ulcers (17%), and myalgia (11%). Cryoglobulinemia was type II in 2/3 of cases. Most cases received specific anti-infectious therapy as first-line therapy, sometimes associated with corticosteroids, achieving sustained remission in the majority of cases. Refractory or relapsing patients, frequently related to HBV infection, showed a complete remission after rituximab in addition to antiviral therapy. In contrast, corticosteroids and/or immunosuppressive agents used in the absence of anti-infectious agents were frequently associated with refractory CryoVas. Viral and pyogenic bacterial infections represent the main causes of non-HCV infectious CryoVas. Antimicrobial therapy is commonly associated with sustained remission. Immunosuppressive agents should be considered only as a second-line option in patients with refractory vasculitis.

Published
2015

2. Tout part de Greenwich…

Author

P.Y. Hatron, Martin F. Lambert, D. Launay, C. Stavris, G. Cardot, A.-L. Buchdahl-Duchange, H. Maillard-Lefebvre, Bruno Graffin, Damien Huglo, Sandrine Morell-Dubois, Benoit Guery, E. Pape, Guillaume Lefèvre, E. Hachulla, Tristan Mirault, and N. Sivova

Subjects
business.industry, Gastroenterology, Internal Medicine, Medicine, business
Published
2011

3. Atteinte respiratoire de la maladie de Horton : 8 observations et revue de la littérature

Author

Bruno Graffin, Marc Aletti, Philippe Carli, Philippe Carassou, F. Banal, Gaël Cinquetti, and Cécile Landais

Subjects
medicine.medical_specialty, Orthopnea, business.industry, Pleural effusion, Retrospective cohort study, General Medicine, Disease, medicine.disease, Dermatology, Rheumatology, Lesion, Giant cell arteritis, Pleurisy, Internal medicine, medicine, medicine.symptom, business
Abstract

BACKGROUND Pleural and pulmonary manifestations of giant cell arteritis are rare and not well known. They can be associated to more typical signs of the disease and to an inflammatory biological syndrome which are comprised in the multisystemic manifestations of the disease. They can be inaugural, leading to a late management if unrecognized. METHODS Retrospective and descriptive study of 8 cases over a 10 year period was conducted. Five females and three males with a 67-year-old average age were included according to the American College of Rheumatology criteria. They illustrated the clinical and/or radiological respiratory manifestations of the disease. RESULTS Pulmonary manifestation was inaugural in six cases over eight. The time to diagnosis range was 15-60 days. Cough was the most frequent symptom (five cases over eight). Dyspnea with orthopnea was described in one case. Pleural and parenchymal radiological manifestations had no specific characteristics: pleurisy, pleural thickening, nodules of variable size, reticular lesions. Temporal artery biopsy was positive in five cases, atypical in one case and negative in two cases. Bronchial and transbronchial biopsies (in two and one cases respectively) did not find any specific lesion. Clinical and radiological signs disappeared quickly after the introduction of glucocorticoid therapy. CONCLUSION The knowledge of these different respiratory manifestations during giant cell arteritis (persistent cough, nodules, pleural effusion) is useful for the clinician. It helps him in prescribing non invasive investigations or even a presumptive glucocorticoid therapy, in an often old and weakened patient.

Published
2010

4. Dites 33 !

Author

J.F. Paris, P. Carli, Cécile Landais, Bruno Graffin, J.-M. Cournac, Maisonabe L, J Beaume, P. Sahuc, A. Grados, and Benhamou Y

Subjects
medicine.medical_specialty, business.industry, Diffuse pain, Gastroenterology, Internal Medicine, Medicine, business, Surgery
Published
2013

5. Çà déméninge !

Author

Y. Salles, R. Tonnelet, F. Banal, Facione-Roger J, Paccalin M, N. Sanmartin, Bruno Graffin, Gaël Cinquetti, and Lagauche D

Subjects
Pediatrics, medicine.medical_specialty, Oligoarthritis, business.industry, Gastroenterology, Internal Medicine, Medicine, business, Surgery
Published
2009

6. Atteinte cardiaque droite révélatrice d’un syndrome carcinoïde

Author

P. Carli, F. Pons, G. Cellarier, Bruno Graffin, C. Jego, R. Poyet, M. Aletti, R. Carlioz, and S. Kerebel

Subjects
Poor prognosis, medicine.medical_specialty, medicine.diagnostic_test, business.industry, Gastroenterology, medicine.disease, Surgery, Pharmacological treatment, Quality of life, Liver biopsy, Valve replacement surgery, Internal Medicine, medicine, Carcinoid Heart Disease, Complication, business, Carcinoid syndrome
Abstract

We report a 75-year-old woman with a severe and symptomatic valvular tricuspid dysfunction, revealing a carcinoid syndrome, confirmed by an octreotid scan and liver biopsy. Carcinoid heart disease is a common complication of carcinoid syndrome associated with poor prognosis. Despite new pharmacological treatment, valve replacement surgery is the only curative treatment. Early diagnosis and multidisciplinary management could improve prognosis and quality of life of these patients.

Published
2009

7. Cave judokanem

Author

C. Treglia, Lambotte O, A. Lecot, J.F. Paris, Cécile Landais, J.-M. Cournac, P. Carli, and Bruno Graffin

Subjects
Spine (zoology), medicine.medical_specialty, business.industry, Gastroenterology, Internal Medicine, medicine, business, Surgery
Published
2009

8. Les non-maladies : un autre domaine de l’interniste

Author

Olivier Gisserot, J.F. Paris, Cécile Landais, P. Carli, and Bruno Graffin

Subjects
Philosophy, General practice, Gastroenterology, Internal Medicine, Humanities
Abstract

Resume Propos Les non-maladies representent un ensemble heterogene de symptomes, de preoccupations ou de phenomenes ressentis ou interpretes a tort comme pathologiques et donc justiciables d’une intervention medicale. La plupart des medecins reconnaissent aisement les etats subjectifs qui ne requierent aucun acte medical, mais peuvent en revanche, a la suite d’une erreur de raisonnement ou d’interpretation medicale, retenir de bonne foi des diagnostics errones, et ainsi creer des non-maladies, qui risquent de faire l’objet de traitements inappropries. Points forts Cette revue (non exhaustive) propose de recenser, sur la base d’exemples de la litterature, les non-maladies anatomiques, cliniques, de laboratoire, de l’imagerie, iatrogeniques, psychiatriques et collectives. L’education de la population, la formation medicale des professions de sante et le controle de la publicite pharmaceutique paraissent utiles pour limiter la medicalisation de problemes non pathologiques, qui sollicitent excessivement les medecins. Conclusion Le specialiste de medecine interne, par sa connaissance eclectique et transversale des specialites medicales, devrait etre capable de reconnaitre et d’enseigner les pieges frequemment poses par les non-maladies.

Published
2008

9. Antiphospholipid antibodies in a family with dehydrated hereditary stomatocytosis

Author

T. Gaillard, C. Martinaud, Jean Delaunay, Olivier Gisserot, P. Brisou, Bruno Graffin, P. Aguilon, Jean Pierre De Jaureguiberry, and Thérèse Cynober

Subjects
chemistry.chemical_compound, chemistry, biology, business.industry, Immunology, Dehydrated hereditary stomatocytosis, biology.protein, Medicine, Hematology, Phosphatidylserine, Antibody, business
Published
2008

10. Défaillance multiviscérale au cours d'un choc septique d'origine urinaire à Escherichia coli: syndrome catastrophique des anticorps antiphospholipides?

Author

Bruno Graffin, P. Goutorbe, J.F. Paris, R. Poyet, P. Carli, and A. Raymond

Subjects
Gynecology, medicine.medical_specialty, Infection urinaire, business.industry, Infeccion urinaria, Gastroenterology, Internal Medicine, medicine, Sepsis syndrome, business
Abstract

Resume Introduction Bien que la presence d'anticorps antiphospholipides soit une situation non exceptionnelle au cours d'une infection, leur responsabilite a l'origine de manifestations thrombotiques graves reste sujette a discussion et pose la question d'un veritable syndrome catastrophique des antiphospholipides ou de defaillance multiviscerale declenchee par le sepsis seul, la presence d'anticorps antiphospholipides n'etant pas pathogene. Faits cliniques Nous rapportons l'observation d'un patient de 68 ans qui a presente au cours d'une infection urinaire a Escherichia coli un choc septique avec insuffisances renale et cardiaque, cytolyse et cholestase hepatiques et une coagulation intravasculaire disseminee. La biologie revelait un taux eleve d'anticorps antiphospholipides IgG (50 UGPL/ml) et une positivite des anticorps antibeta-2-glycoproteine-1. L'evolution sera favorable sous traitement antibiotique et immunoglobulines intraveineuses. Discussion Le diagnostic de la pathogenie de la defaillance multiviscerale est fonde sur les manifestations cliniques publiees au cours du syndrome catastrophique des antiphospholipides, l'evolution et la persistance des anticorps antiphospholipides apres la guerison de l'infection, et la comparaison avec les atteintes viscerales expliquees par le sepsis seul.

Published
2007

11. Reproducible and sustained efficacy of targeted therapy with vemurafenib in patients with BRAF(V600E)-mutated Erdheim-Chester disease

Author

Julien Haroche, Jean-Paul Ory, Jean Donadieu, François Lifermann, Ahmed Idbaih, Stéphane Barete, Baptiste Hervier, Philippe Grenier, Philippe Maksud, Fleur Cohen-Aubart, Frédéric Charlotte, Neila Benameur, Dan Toledano, Philippe Cluzel, Aurélie Drier, Bruno Graffin, Zahir Amoura, Sophie Besnard, Jean-François Emile, Brigitte Granel, and Laurent Arnaud

Subjects
Oncology, Adult, Male, Proto-Oncogene Proteins B-raf, Cancer Research, medicine.medical_specialty, Pathology, Erdheim-Chester Disease, Indoles, medicine.medical_treatment, Glutamic Acid, Disease, Targeted therapy, Langerhans cell histiocytosis, Fluorodeoxyglucose F18, Internal medicine, medicine, Humans, In patient, Molecular Targeted Therapy, Vemurafenib, Aged, Skin, Sulfonamides, business.industry, Valine, Middle Aged, medicine.disease, Clinical trial, Treatment Outcome, Histiocytoses, Positron-Emission Tomography, Erdheim–Chester disease, Mutation, Female, Radiopharmaceuticals, business, medicine.drug
Abstract

Purpose Histiocytoses are rare disorders with heterogeneous prognosis. BRAFV600E mutations have been observed in half of patients with Langerhans cell histiocytosis (LCH) and in 50% to 100% of patients with Erdheim-Chester disease (ECD) patients. We recently reported short-term efficacy of a BRAF inhibitor (vemurafenib) in three patients with multisystemic ECD. Patients and Methods Vemurafenib was given to eight patients with multisystemic ECD with CNS and/or cardiac involvement. All patients were refractory to first-line treatment and harbored a BRAFV600E mutation. Four patients also had LCH lesions. Positron emission tomography (PET) scan response at month 6 was used as the main evaluation criterion. Secondary evaluation criteria were comparison at baseline and at last visit of PET and of cardiovascular and cerebral infiltrations (computed tomography scan and magnetic resonance imaging [MRI]). Results All patients were partial metabolic responders at 6 months of vemurafenib, and the median reduction in maximum standardized uptake value was 63.5% (range, 41.3% to 86.9%). Evaluation of cardiac and aortic infiltrations showed that seven patients had a partial response and one patient had stable disease according to surface measurements derived from RECIST criteria. The four patients with infratentorial CNS infiltration had an objective decrease of the lesions on MRI. All patients had an improvement of general symptoms and a persistent response to vemurafenib, with a median follow-up time of 10.5 months (range, 6 to 16 months). Skin adverse effects were frequent and severe. Conclusion Vemurafenib has an objective and sustained efficacy in BRAFV600E-mutated ECD as second-line therapy. In contrast to melanoma, no resistance has emerged to date after 6 to 16 months.

Published
2014

12. Le hasard fait parfois mal les choses !

Author

M. Cabon, Véronique Dorvaux, A. Valois, Bruno Graffin, Philippe Carassou, J.-M. Puyhardy, Gaël Cinquetti, X. Roux, C. Cuvelier, Serge Védy, and J. Schmidt

Subjects
Gastroenterology, Internal Medicine
Abstract

Service de medecine interne, hopital d’instruction des armees Legouest, 27, avenue de Plantieres, BP 90001, 57077 Metz cedex 3, France Service de biologie medicale, hopital d’instruction des armees Legouest, 27, avenue de Plantieres, BP 90001, 57077 Metz cedex 3, France Service d’hematologie clinique, hopital Bon Secours, 1, place Ph.-de-Vigneulles, 57038 Metz cedex 01, France Service de medecine interne, hopital Nord, CHU d’Amiens, 2, place Victor-Pauchet, 80054 Amiens, France

Published
2013

13. Treatment of a life-threatening laryngeal bradykinin angio-oedema precipitated by dipeptidylpeptidase-4 inhibitor and angiotensin-I converting enzyme inhibitor with prothrombin complex concentrates

Author

C. Landy, Gisèle Kanny, J. Nadaud, M Hosotte, I. Millot, D. Plancade, Christian Drouet, Céline Ragot, and Bruno Graffin

Subjects
chemistry.chemical_compound, Anesthesiology and Pain Medicine, chemistry, business.industry, Medicine, Bradykinin, Pharmacology, business, Angiotensin I converting enzyme, Angio-oedema, PROTHROMBIN COMPLEX
Published
2012

14. Association of both Langerhans cell histiocytosis and Erdheim-Chester disease linked to the BRAFV600E mutation

Author

Laurent Arnaud, Stéphane Barete, Jean Donadieu, Antoine Néel, Valérie Taly, Baptiste Hervier, Julien Haroche, Karine Cury, Zahir Amoura, Jean-François Emile, Jean-Marie Michot, Maud Bézier, Camille Roubille, Aude Rigolet, Véronique Meignin, Eric Hachulla, Bruno Graffin, Laurence Marie, Olivier Hermine, Marie Conrad, Elise Kostrzewa, Frédéric Charlotte, François Lifermann, Thierry Carmoi, Carles Villabona, CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Immunité et Infection, Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR113-Sorbonne Université (SU), Service d'Anatomie et cytologie pathologiques [CHU Pitié-Salpêtrière] (ACP), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Pierre et Marie Curie - Paris 6 (UPMC), Service d'hématologie-immunologie-oncologie pédiatrique [CHU Trousseau], CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre de référence des Histiocytoses [HU Saint-Louis, Lariboisière, Fernand-Widal - APHP], Hôpitaux Universitaires Saint-Louis, Lariboisière, Fernand-Widal, Service de médecine interne [Nantes], Université de Nantes (UN)-Hôtel-Dieu-Centre hospitalier universitaire de Nantes (CHU Nantes), Service de Médecine Interne [Dax], Centre Hospitalier de Dax, Department of Endocrinology [Barcelona, Spain], L’Hospitalet de Llobregat [Barcelona, Spain]-Hospital de Bellvitge [Barcelona, Spain], Service de Médecine Interne [HI des Armées Legouest, Metz], Hôpital d’Instruction des Armées Legouest [Metz], Service d'hématologie [CHU Necker], CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS), Service de Médecine Interne [CHRU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Hôpital d'Instruction des Armées du Val de Grâce, Service de Santé des Armées, Hôpital Saint-Louis, Université Paris Diderot - Paris 7 (UPD7)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre Hospitalier Raincy-Montfermeil, CHU Bordeaux [Bordeaux], Hôpital Bicêtre, Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, Service de dermatologie et allergologie [CHU Tenon], CHU Tenon [AP-HP], Bases moléculaires de la réponse aux xénobiotiques (U775 (IFR95)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service d'anatomie pathologique [CHU Ambroise-Paré], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Ambroise Paré [AP-HP], French Histiocytoses Study Group : Bulifon S, Brousse N, Tazi A, Girerd X, de Gennes C, de Lassale E, Leclair F, Rieu P, De Wazière B, Ory JP, Lambotte O, Meekel P, Cohen-Aubart F, Hélias-Rodzewicz Z, Rousselet-Chapeau MC, Vital-Durand D, Hamidou MA., Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), IFR113-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Service de médecine interne et d'immunologie clinique [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université, Sorbonne Université (SU), Laboratoire Géomatériaux (DGCB-LGM), École Nationale des Travaux Publics de l'État (ENTPE)-Centre National de la Recherche Scientifique (CNRS), Service d’anatomie et cytologie pathologiques [CHU Pitié-Salpêtrière], Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université-Sorbonne Université, Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Université Paris Descartes - Faculté de Médecine (UPD5 Médecine), Université Paris Descartes - Paris 5 (UPD5), Sorbonne Université-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Département de Rhumatologie[Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Lapeyronie, Service de médecine interne, Gvh et Gvl : Physiopathologie Chez l'Homme et Chez l'Animal, Incidence et Role Therapeutique, Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), service de Médecine Interne et d'Immunologie Clinique [AP-HP Hôpital Bicêtre], Université Paris-Sud - Paris 11 (UP11)-Hôpital Bicêtre, Assistance Publique - Hôpitaux de Paris (AP-HP), CHU Tenon [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université, Médecine Personnalisée, Pharmacogénomique, Optimisation Thérapeutique (MEPPOT - U1147), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Dermatologie [CHU Tenon], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Tenon [APHP], Biomarqueurs et essais cliniques en Cancérologie et Onco-Hématologie (BECCOH), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Saclay, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Trousseau [APHP], CHU Pitié-Salpêtrière [APHP], Université Paris Diderot - Paris 7 (UPD7)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Tenon [APHP], Laboratoire épidémiologie et oncogénèse des tumeurs digestives, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), TALY, Valerie, and Service d'Anatomie et cytologie pathologiques = Service de Pathologie [CHU Pitié-Salpêtrière] (ACP)

Subjects
Adult, Male, Proto-Oncogene Proteins B-raf, Pathology, medicine.medical_specialty, Erdheim-Chester Disease, Adolescent, genetic structures, [SDV]Life Sciences [q-bio], Immunology, DNA Mutational Analysis, Mutation, Missense, Kaplan-Meier Estimate, Biology, medicine.disease_cause, Biochemistry, Young Adult, Langerhans cell histiocytosis, Inside BLOOD Commentary, Biopsy, medicine, Missense mutation, Humans, Genetic Predisposition to Disease, Child, ComputingMilieux_MISCELLANEOUS, Aged, Mutation, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, medicine.diagnostic_test, Cell Biology, Hematology, Middle Aged, medicine.disease, 3. Good health, [SDV] Life Sciences [q-bio], Histiocytosis, Histiocytosis, Langerhans-Cell, Treatment Outcome, Histiocytoses, Child, Preschool, Erdheim–Chester disease, Female, V600E, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Comment in "A common progenitor cell in LCH and ECD. [Blood. 2014]"; International audience; Histiocytoses are a group of heterogeneous diseases that mostly comprise Langerhans cell histiocytosis (LCH) and non-LCH. The association of LCH with non-LCH is exceptional. We report 23 patients with biopsy-proven LCH associated with Erdheim-Chester disease (ECD) (mixed histiocytosis) and discuss the significance of this association. We compare the clinical phenotypes of these patients with those of 56 patients with isolated LCH and 53 patients with isolated ECD. The average age at diagnosis was 43 years. ECD followed (n = 12) or was diagnosed simultaneously with (n = 11) but never preceded LCH. Although heterogeneous, the phenotype of patients with mixed histiocytosis was closer to that of isolated ECD than to that of isolated LCH (principal component analysis). LCH and ECD improved in response to interferon alpha-2a treatment in only 50% of patients (8 of 16). We found the BRAF(V600E) mutation in 11 (69%) of 16 LCH lesions and in 9 (82%) of 11 ECD lesions. Eight patients had mutations in both ECD and LCH biopsies. Our findings indicate that the association of LCH and ECD is not fortuitous and suggest a link between these diseases involving the BRAF(V600E) mutation.

Published
2014

15. Les ténosynovites mycosiques. Revue de la littérature à propos d’une observation de blastomycose

Author

Hubert de Belenet, Jean-David Cohen, Didier Monchy, Pierre Jeandel, Christian Flin, Bruno Graffin, Pierre-Yves Chouc, and Jean Fulpin

Subjects
Gynecology, medicine.medical_specialty, Rheumatology, biology, Blastomyces dermatitidis, business.industry, medicine, biology.organism_classification, North American Blastomycosis, medicine.disease, business, Blastomycosis
Abstract

Resume Les tenosynovites mycosiques sont une situation rare, rencontree sur un mode sporadique et principalement chez le sujet immunodeprime. Nous rapportons l’observation d’une blastomycose nord-americaine d’importation chez un jardinier de 63 ans immunocompetent. La revue de la litterature permet de degager les caracteristiques cliniques et paracliniques devant lesquelles le diagnostic de tenosynovite mycosique peut et doit etre evoque ainsi que les principaux agents responsables de ces tenosynovites.

Published
2001

16. A case report of Blastomyces tenosynovitis, with a literature review on fungal tenosynovitis

Author

Jean Fulpin, Didier Monchy, Jean-David Cohen, Pierre-Yves Chouc, Hubert de Belenet, Christian Flin, Bruno Graffin, and Pierre Jeandel

Subjects
Blastomyces, medicine.medical_specialty, Pathology, Tenosynovitis, biology, business.industry, Blastomyces dermatitidis, medicine.disease, biology.organism_classification, Dermatology, Rheumatology, Medicine, In patient, business, North American Blastomycosis, Mycosis
Abstract

Fungal tenosynovitis is a rare condition that occurs sporadically, mainly in patients with immunodeficiencies. We report an imported case of North American blastomycosis in an immunocompetent 63-year-old gardener. Findings that should suggest fungal tenosynovitis and the main causative fungi are reviewed based on data from the literature.

Published
2001

17. Œsophagite à éosinophiles : une cause rare de dysphagie

Author

Bruno Graffin, P. Rey, Christian Bredin, M. Pernin, P Hoeffler, D. Billot, and C. Pillot

Subjects
Allergy, medicine.medical_specialty, medicine.diagnostic_test, business.industry, Impaction, Incidence (epidemiology), Gastroenterology, medicine.disease, Dysphagia, Dermatology, Surgery, Pathognomonic, Biopsy, Internal Medicine, medicine, medicine.symptom, Eosinophilic esophagitis, business, High-power field
Abstract

Eosinophilic esophagitis is an unrecognized and emerging entity. Its incidence increases with allergic disorders. A 29-year-old man presented with a 4-year history of intermittent and paroxysmal dysphagia. The triad including allergy, young age, and impaction of foreign bodies, combined with a chronic dysphagia is almost pathognomonic of eosinophilic esophagitis. Endoscopic esophageal features can be diverse, so systematic esophageal biopsies are required. Diagnosis is established with the demonstration of an eosinophilic infiltrate with a cell count exceeding 15 eosinophils per high power field (×400). First line therapy includes swallowed topical corticosteroids and removal of an allergic cause, when it could be identified.

Published
2010

18. Un prurit épileptique

Author

D. Andriamanantena, J. Facione, F. Banal, Bruno Graffin, Y. Salles, and Gaël Cinquetti

Subjects
medicine.medical_specialty, business.industry, Medicine, General Medicine, business, Dermatology
Published
2010

19. Complications rares d’un syndrome de Lemierre : localisations sternoclaviculaires et pulmonaires excavées

Author

N. Lemant-Pluvinage, F. Banal, Bruno Graffin, Gaël Cinquetti, A. Genest, J. Wannin, Y. Salles, P. Noisette, and S. Mohamed

Subjects
medicine.medical_specialty, business.industry, Respiratory disease, Sternoclavicular joint, Gastroenterology, Arthritis, medicine.disease, Dermatology, Surgery, Pneumonia, medicine.anatomical_structure, Lung disease, Lemierre's syndrome, Internal Medicine, Medicine, Septic arthritis, business, Complication, human activities
Abstract

We report a 27-year-old man who presented with a Lemierre's syndrome associated with two uncommon complications: a septic sternoclavicular joint arthritis and a cavitating pneumonia.

Published
2009

20. Polyarthrite œdémateuse et myopéricardite révélatrices d’une périartérite noueuse

Author

P. Carli, M. Aletti, Bruno Graffin, S. Kerebel, R. Poyet, J.F. Paris, and Cécile Landais

Subjects
Pathology, medicine.medical_specialty, Acute polyarthritis, medicine.diagnostic_test, Polyarteritis nodosa, business.industry, Gastroenterology, medicine.disease, Chest pain, Pitting edema, Dermatology, Synovitis, Necrotizing Vasculitis, Biopsy, Internal Medicine, medicine, medicine.symptom, business, Myopericarditis
Abstract

Remitting symmetrical seronegative synovitis with pitting edema (RS3PE) syndrome is a rare type of seronegative polyarthritis occurring in the elderly. It can be associated to various diseases. We report a case of RS3PE syndrome associated with myopericarditis, leading to the diagnosis of polyarteritis nodosa in a 71-year-old patient admitted to the hospital for a febrile acute polyarthritis with pitting edema of the hands associated with a marked inflammatory syndrome. On second day of hospitalization, a sustained chest pain led to the diagnosis of myopericarditis. Muscular biopsy showed necrotizing vasculitis, characteristic of polyarteritis nodosa. The coexistence of RS3PE and myopericarditis has never been described in the literature. Its association with polyarteritis nodosa is also very rare and only one case has been previously reported.

Published
2009

21. Maladie thromboembolique récidivante après splénectomie pour stomatocytose héréditaire

Author

Bruno Graffin, Cécile Landais, P. Carli, Olivier Gisserot, and J.P. de Jaureguiberry

Subjects
Gastroenterology, Internal Medicine
Abstract

Resume Fait clinique Le diagnostic de stomatocytose hereditaire avec hematies deshydratees (xerocytose) est porte chez une femme de 57 ans, splenectomisee il y a 30 ans pour une anemie hemolytique chronique, dont les suites ont ete perturbees par de nombreux evenements thrombotiques veineux des membres inferieurs et de la veine porte. Discussion Les criteres de diagnostic de cette rare anemie hemolytique constitutionnelle et son demembrement sont rappeles, et les mecanismes de la thrombophilie sont discutes. Cette observation conduit a rappeler que la splenectomie doit etre formellement contre-indiquee au cours de la stomatocytose hereditaire, et que la depletion martiale est necessaire pour prevenir les complications de la surcharge en fer, tres frequente au cours de cette affection.

Published
2007

22. Diabète insipide central inaugural d'une leucémie myélomonocytaire chronique

Author

G. Leyral, J.F. Paris, Bruno Graffin, P. Bernard, P. Carli, Olivier Gisserot, Cécile Landais, and M. Aletti

Subjects
Gynecology, Monosomy, medicine.medical_specialty, Fatal outcome, business.industry, Myelomonocytic leukemia, Gastroenterology, Aneuploidy, Chronic myelomonocytic leukemia, medicine.disease, Leukemia, Internal Medicine, medicine, business
Abstract

Resume Introduction Le diabete insipide central a de multiples causes, notamment traumatiques, postchirurgicales, mais il est exceptionnellement rapporte a une dysmyelopoiese. Fait clinique Nous presentons l'observation d'un patient de 61 ans chez lequel un diabete insipide central a precede de 17 mois l'apparition d'une leucemie myelomonocytaire chronique avec la presence d'une monosomie 7 sur toutes les mitoses du caryotype medullaire. L'acutisation en trois mois de l'hemopathie a entraine le deces rapide du patient. Discussion Avant de classer idiopathique un diabete insipide central, il convient d'analyser avec soin l'hemogramme et de le surveiller regulierement afin de depister le plus precocement possible une eventuelle leucemie myelomonocytaire chronique avant sa transformation en leucemie myeloide aigue. En effet, l'acutisation de la leucemie myelomonocytaire chronique, surtout en presence d'anomalie chromosomique telle qu'une monosomie 7, rend le pronostic extremement sombre.

Published
2007

23. Ça vous fait une belle jambe !!

Author

Cécile Landais, P. Carli, J.F. Paris, Bruno Graffin, and M. Agousty

Subjects
Tomography x ray computed, business.industry, Gastroenterology, Internal Medicine, Medicine, business, Nuclear medicine, Muscle hypertrophy
Published
2005

24. Dissection aortique au cours de la maladie de Horton

Author

Serge Cremades, P. Carli, M. Chemsi, J.F. Paris, G. Leyral, F. Sauvet, C. Jego, and Bruno Graffin

Subjects
business.industry, Gastroenterology, Internal Medicine, Medicine, business
Published
2004

25. La folie érotique et amnésiante de Taiwan

Author

G. Leyral, Bruno Graffin, Serge Cremades, P. Carli, J.F. Paris, V. Mandier-Michaut, and Cécile Landais

Subjects
business.industry, Gastroenterology, Internal Medicine, Medicine, business
Published
2003

29. Three related cases of cutaneous anthrax in France: clinical and laboratory aspects

Author

Jean-Michel Puyhardy, Pierre-Yves Girault, Anne-Laure Dupuy, Yolande Veran, Olivier Oddoux, Gaël Cinquetti, Anne Couderc, Pauline Guyot, Céline Ragot, F. Banal, Corentine Alauzet, and Bruno Graffin

Subjects
Male, medicine.medical_specialty, Adolescent, Disease, Cutaneous anthrax, Anthrax, Pharmacotherapy, Medicine, Animals, Humans, biology, Medical treatment, business.industry, fungi, Agriculture, General Medicine, Skin Diseases, Bacterial, Middle Aged, biology.organism_classification, Dermatology, Bacillus anthracis, Immunology, Cattle, France, business, Abattoirs
Abstract

Anthrax is an acute bacterial infection caused by Bacillus anthracis. The infection is cutaneous in about 95% of human cases and respiratory in about 5%. Approximately 2000 cases of cutaneous anthrax are reported annually worldwide. This disease became exceptional in Europe thanks to strict veterinarian monitoring. The last human cases of anthrax indicated in France were in 1997. We report 3 new related cases of naturally acquired cutaneous anthrax that occurred in France in 2008. The unique features of these cases include the atypical clinical presentation and the contribution of the rapid and specific diagnosis techniques by polymerase chain reaction.In cutaneous forms of anthrax, although the local course is not influenced by the treatment, antibiotic therapy is necessary to control any bacterial distribution. A case of exposure similar to that of a confirmed human case or an exposure identified by epidemiologic inquiry should usually result in chemoprophylaxis. Chemoprophylaxis for the close relations of a patient or for health workers is unnecessary since person-to-person transmission has not been reported.

Published
2009

30. [Respiratory manifestations of giant cell arteritis: 8 cases and review of the literature]

Author

Philippe, Carassou, Marc, Aletti, Gaël, Cinquetti, Frédéric, Banal, Cécile, Landais, Bruno, Graffin, and Philippe, Carli

Subjects
Aged, 80 and over, Male, Giant Cell Arteritis, Humans, Female, Middle Aged, Respiration Disorders, Aged, Retrospective Studies
Abstract

Pleural and pulmonary manifestations of giant cell arteritis are rare and not well known. They can be associated to more typical signs of the disease and to an inflammatory biological syndrome which are comprised in the multisystemic manifestations of the disease. They can be inaugural, leading to a late management if unrecognized.Retrospective and descriptive study of 8 cases over a 10 year period was conducted. Five females and three males with a 67-year-old average age were included according to the American College of Rheumatology criteria. They illustrated the clinical and/or radiological respiratory manifestations of the disease.Pulmonary manifestation was inaugural in six cases over eight. The time to diagnosis range was 15-60 days. Cough was the most frequent symptom (five cases over eight). Dyspnea with orthopnea was described in one case. Pleural and parenchymal radiological manifestations had no specific characteristics: pleurisy, pleural thickening, nodules of variable size, reticular lesions. Temporal artery biopsy was positive in five cases, atypical in one case and negative in two cases. Bronchial and transbronchial biopsies (in two and one cases respectively) did not find any specific lesion. Clinical and radiological signs disappeared quickly after the introduction of glucocorticoid therapy.The knowledge of these different respiratory manifestations during giant cell arteritis (persistent cough, nodules, pleural effusion) is useful for the clinician. It helps him in prescribing non invasive investigations or even a presumptive glucocorticoid therapy, in an often old and weakened patient.

Published
2009

38. Beta-carotene-induced hepatic fibrosis

Author

Bruno, Graffin, Isabelle, Genty, Elodie, Crétel, Rodolphe, Jean, and Jean Marc, Durand

Subjects
Liver Cirrhosis, Alcoholism, Cholagogues and Choleretics, Ursodeoxycholic Acid, Humans, Female, beta Carotene, Retinitis Pigmentosa, Aged
Published
2002

40. PROMM : une myotonie bien interniste !

Author

E. Poisnel, D. Delarbre, Bruno Graffin, P. Carli, C. Landais, J.F. Paris, Guillaume Bassez, François-Jérôme Authier, and C. Delavergne

Subjects
Gastroenterology, Internal Medicine
Published
2014

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