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324 results on '"Bruno Canard"'

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1. Biophysical and structural study of La Crosse virus endonuclease inhibition for the development of new antiviral options

3. Identification of Novel Non-Nucleoside Inhibitors of Zika Virus NS5 Protein Targeting MTase Activity

4. Inhibition of Arenaviridae nucleoprotein exonuclease by bisphosphonate

5. A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase

6. Viral Instant Mutation Viewer: A Tool to Speed Up the Identification and Analysis of New SARS-CoV-2 Emerging Variants and Beyond

7. Observation of arenavirus nucleoprotein heptamer assembly

8. Simeprevir Potently Suppresses SARS-CoV‑2 Replication and Synergizes with Remdesivir

9. Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis

10. Amino Acid Polymorphisms on the Brazilian Strain of Yellow Fever Virus Methyltransferase Are Related to the Host’s Immune Evasion Mediated by Type I Interferon

11. Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective

12. A Versatile Class of 1,4,4-Trisubstituted Piperidines Block Coronavirus Replication In Vitro

13. The methyltransferase domain of the Respiratory Syncytial Virus L protein catalyzes cap N7 and 2'-O-methylation.

14. Synthesis, Structure–Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs as Inhibitors of SARS-CoV-2 Replication

15. Crystal structures of Lymphocytic choriomeningitis virus endonuclease domain complexed with diketo-acid ligands

16. The Curious Case of the Nidovirus Exoribonuclease: Its Role in RNA Synthesis and Replication Fidelity

17. Brothers in Arms: Structure, Assembly and Function of Arenaviridae Nucleoprotein

18. Structural and Functional Basis of the Fidelity of Nucleotide Selection by Flavivirus RNA-Dependent RNA Polymerases

19. The RNA template channel of the RNA-dependent RNA polymerase as a target for development of antiviral therapy of multiple genera within a virus family.

20. Primer-dependent and primer-independent initiation of double stranded RNA synthesis by purified Arabidopsis RNA-dependent RNA polymerases RDR2 and RDR6.

21. Molecular basis for nucleotide conservation at the ends of the dengue virus genome.

22. Crystal structure and functional analysis of the SARS-coronavirus RNA cap 2'-O-methyltransferase nsp10/nsp16 complex.

23. The hexamer structure of Rift Valley fever virus nucleoprotein suggests a mechanism for its assembly into ribonucleoprotein complexes.

24. Comparative production analysis of three phlebovirus nucleoproteins under denaturing or non-denaturing conditions for crystallographic studies.

25. The N-terminal domain of the arenavirus L protein is an RNA endonuclease essential in mRNA transcription.

27. In vitro reconstitution of SARS-coronavirus mRNA cap methylation.

28. 1H, 13C, 15N backbone resonance assignment of apo and ADP-ribose bound forms of the macro domain of Hepatitis E virus through solution NMR spectroscopy

29. Facile access to 4′-(N-acylsulfonamide) modified nucleosides and evaluation of their inhibitory activity against SARS-CoV-2 RNA cap N7-guanine-methyltransferase nsp14

31. Structure-guided optimization of adenosine mimetics as selective and potent inhibitors of coronavirus nsp14 N7-methyltransferases

32. The SARS-CoV nsp12 Polymerase Active Site Is Tuned for Large-Genome Replication

33. Identification of potent inhibitors of arenavirus and SARS-CoV-2 exoribonucleases by fluorescence polarization assay

34. AT-752 targets multiple sites and activities on the Dengue virus replication enzyme NS5

35. An appeal for an objective, open, and transparent scientific debate about the origin of SARS-CoV-2

36. Potent Inhibition of SARS-CoV-2 nsp14 N 7-Methyltransferase by Sulfonamide-Based Bisubstrate Analogues

37. Inhibition of

38. Kill or corrupt: Mechanisms of action and drug-resistance of nucleotide analogues against SARS-CoV-2

39. Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes the hexameric complex

40. Structure-function analysis of the nsp14 N7-guanine methyltransferase reveals an essential role in Betacoronavirus replication

41. A high-throughput fluorescence polarization assay to discover inhibitors of arenavirus and coronavirus exoribonucleases

42. Evaluation of AT-752, a Double Prodrug of a Guanosine Nucleotide Analog with In Vitro and In Vivo Activity against Dengue and Other Flaviviruses

43. Inhibition of sars-cov-2 polymerase by nucleotide analogs from a single-molecule perspective

44. Author response: Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective

45. A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase

46. Structure and Sequence Requirements for RNA Capping at the Venezuelan Equine Encephalitis Virus RNA 5′ End

47. The enzymes for genome size increase and maintenance of large (+)RNA viruses

48. [The WHO mission report struggles to trace the origins of the SARS-CoV-2 epidemic]

49. Simeprevir Potently Suppresses SARS-CoV-2 Replication and Synergizes with Remdesivir

50. Protein-primed RNA synthesis in SARS-CoVs and structural basis for inhibition by AT-527

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