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122 results on '"Bruno, Benedicte"'

1. Population Pharmacokinetics of Inotuzumab Ozogamicin in Pediatric Relapsed/Refractory B-Cell Precursor Acute Lymphoblastic Leukemia: Results of Study ITCC-059

Author

Wu, Jen-Hao, Pennesi, Edoardo, Bautista, Francisco, Garrett, May, Fukuhara, Kei, Brivio, Erica, Ammerlaan, Anneke C. J., Locatelli, Franco, van der Sluis, Inge M., Rossig, Claudia, Chen-Santel, Christiane, Bielorai, Bella, Petit, Arnaud, Starý, Jan, Díaz-de-Heredia, Cristina, Rives, Susana, O’Marcaigh, Aengus, Rizzari, Carmelo, Engstler, Gernot, Nysom, Karsten, Rubio-San-Simón, Alba, Bruno, Benedicte, Bertrand, Yves, Brethon, Benoît, Rialland, Fanny, Plat, Geneviève, Dirksen, Uta, Sramkova, Lucie, Zwaan, C. Michel, and Huitema, Alwin D. R.

Published
2024
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4. Real-world use of defibrotide for veno-occlusive disease/sinusoidal obstruction syndrome: the DEFIFrance Registry Study

Author

Mohty, Mohamad, Blaise, Didier, Peffault de Latour, Régis, Labopin, Myriam, Bourhis, Jean Henri, Bruno, Benedicte, Ceballos, Patrice, Detrait, Marie, Gandemer, Virginie, Huynh, Anne, Izadifar-Legrand, Faezeh, Jubert, Charlotte, Labussière-Wallet, Hélène, Lebon, Delphine, Maury, Sébastien, Paillard, Catherine, Pochon, Cécile, Renard, Cecile, Rialland, Fanny, Schneider, Pascale, Sirvent, Anne, Asubonteng, Kobby, Guindeuil, Gwennaëlle, Yakoub-Agha, Ibrahim, and Dalle, Jean-Hugues

Published
2023
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6. Inotuzumab ozogamicin as single agent in pediatric patients with relapsed and refractory acute lymphoblastic leukemia: results from a phase II trial

Author

Pennesi, Edoardo, Michels, Naomi, Brivio, Erica, van der Velden, Vincent H. J., Jiang, Yilin, Thano, Adriana, Ammerlaan, Anneke J. C., Boer, Judith M., Beverloo, H. Berna, Sleight, Barbara, Chen, Ying, Vormoor-Bürger, Britta, Rives, Susana, Bielorai, Bella, Rössig, Claudia, Petit, Arnaud, Rizzari, Carmelo, Engstler, Gernot, Starý, Jan, Bautista Sirvent, Francisco J., Chen-Santel, Christiane, Bruno, Benedicte, Bertrand, Yves, Rialland, Fanny, Plat, Geneviève, Reinhardt, Dirk, Vinti, Luciana, Von Stackelberg, Arend, Locatelli, Franco, and Zwaan, Christian M.

Published
2022
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7. Hematopoietic stem cell transplantation for Wiskott-Aldrich syndrome: an EBMT Inborn Errors Working Party analysis

Author

Albert, Michael H., Slatter, Mary A., Gennery, Andrew R., Güngör, Tayfun, Bakunina, Katerina, Markovitch, Benyamin, Hazelaar, Sheree, Sirait, Tiarlan, Courteille, Virginie, Aiuti, Alessandro, Aleinikova, Olga V., Balashov, Dmitry, Bernardo, Maria Ester, Bodova, Ivana, Bruno, Benedicte, Cavazzana, Marina, Chiesa, Robert, Fischer, Alain, Hauck, Fabian, Ifversen, Marianne, Kałwak, Krzysztof, Klein, Christoph, Kulagin, Alexander, Kupesiz, Alphan, Kuskonmaz, Baris, Lindemans, Caroline A., Locatelli, Franco, Lum, Su Han, Maschan, Alexey, Meisel, Roland, Moshous, Despina, Porta, Fulvio, Sauer, Martin G., Sedlacek, Petr, Schulz, Ansgar, Suarez, Felipe, Vallée, Tanja C., Winiarski, Jacek H., Zecca, Marco, Neven, Bénédicte, Veys, Paul, and Lankester, Arjan C.

Published
2022
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8. Population Pharmacokinetics of Inotuzumab Ozogamicin in Pediatric Relapsed/Refractory B-Cell Precursor Acute Lymphoblastic Leukemia: Results of Study ITCC-059

Author

Apotheek O&O&O, Cancer, Wu, Jen Hao, Pennesi, Edoardo, Bautista, Francisco, Garrett, May, Fukuhara, Kei, Brivio, Erica, Ammerlaan, Anneke C.J., Locatelli, Franco, van der Sluis, Inge M., Rossig, Claudia, Chen-Santel, Christiane, Bielorai, Bella, Petit, Arnaud, Starý, Jan, Díaz-de-Heredia, Cristina, Rives, Susana, O’Marcaigh, Aengus, Rizzari, Carmelo, Engstler, Gernot, Nysom, Karsten, Rubio-San-Simón, Alba, Bruno, Benedicte, Bertrand, Yves, Brethon, Benoît, Rialland, Fanny, Plat, Geneviève, Dirksen, Uta, Sramkova, Lucie, Zwaan, C. Michel, Huitema, Alwin D.R., Apotheek O&O&O, Cancer, Wu, Jen Hao, Pennesi, Edoardo, Bautista, Francisco, Garrett, May, Fukuhara, Kei, Brivio, Erica, Ammerlaan, Anneke C.J., Locatelli, Franco, van der Sluis, Inge M., Rossig, Claudia, Chen-Santel, Christiane, Bielorai, Bella, Petit, Arnaud, Starý, Jan, Díaz-de-Heredia, Cristina, Rives, Susana, O’Marcaigh, Aengus, Rizzari, Carmelo, Engstler, Gernot, Nysom, Karsten, Rubio-San-Simón, Alba, Bruno, Benedicte, Bertrand, Yves, Brethon, Benoît, Rialland, Fanny, Plat, Geneviève, Dirksen, Uta, Sramkova, Lucie, Zwaan, C. Michel, and Huitema, Alwin D.R.

Published
2024

9. Population Pharmacokinetics of Inotuzumab Ozogamicin in Pediatric Relapsed/Refractory B-Cell Precursor Acute Lymphoblastic Leukemia:Results of Study ITCC-059

Author

Wu, Jen-Hao, Pennesi, Edoardo, Bautista, Francisco, Garrett, May, Fukuhara, Kei, Brivio, Erica, Ammerlaan, Anneke C. J., Locatelli, Franco, van der Sluis, Inge M., Rossig, Claudia, Chen-Santel, Christiane, Bielorai, Bella, Petit, Arnaud, Stary, Jan, Diaz-de-Heredia, Cristina, Rives, Susana, O'Marcaigh, Aengus, Rizzari, Carmelo, Engstler, Gernot, Nysom, Karsten, Rubio-San-Simon, Alba, Bruno, Benedicte, Bertrand, Yves, Brethon, Benoit, Rialland, Fanny, Plat, Genevieve, Dirksen, Uta, Sramkova, Lucie, Zwaan, C. Michel, Huitema, Alwin D. R., Wu, Jen-Hao, Pennesi, Edoardo, Bautista, Francisco, Garrett, May, Fukuhara, Kei, Brivio, Erica, Ammerlaan, Anneke C. J., Locatelli, Franco, van der Sluis, Inge M., Rossig, Claudia, Chen-Santel, Christiane, Bielorai, Bella, Petit, Arnaud, Stary, Jan, Diaz-de-Heredia, Cristina, Rives, Susana, O'Marcaigh, Aengus, Rizzari, Carmelo, Engstler, Gernot, Nysom, Karsten, Rubio-San-Simon, Alba, Bruno, Benedicte, Bertrand, Yves, Brethon, Benoit, Rialland, Fanny, Plat, Genevieve, Dirksen, Uta, Sramkova, Lucie, Zwaan, C. Michel, and Huitema, Alwin D. R.

Abstract

Background and Objective: Inotuzumab ozogamicin is an antibody-drug conjugate approved for treating relapsed/refractory B-cell precursor acute lymphoblastic leukemia (BCP-ALL) in adults. Pediatric pharmacokinetic data of inotuzumab ozogamicin are lacking. This study is the first to examine the population pharmacokinetics of inotuzumab ozogamicin in pediatric patients with relapsed/refractory BCP-ALL. Methods: From 531 adult patients with B-cell non-Hodgkin’s lymphoma, 234 adult patients with BCP-ALL, and 53 pediatric patients with BCP-ALL, 8924 inotuzumab ozogamicin serum concentrations were analyzed using non-linear mixed-effects modeling. A published adult inotuzumab ozogamicin population-pharmacokinetic model, a two-compartment model with linear and time-dependent clearance, was adapted to describe the pediatric data. Results: Modifications in this analysis, compared to the published adult model, included: (i) re-estimating pharmacokinetic parameters and covariate effects; (ii) modifying covariate representation; and (iii) introducing relevant pediatric covariate effects (age on the decay coefficient of time-dependent clearance and ALL effect (disease type and/or different bioanalytical analysis methods) on initial values of time-dependent clearance). For patients with relapsed/refractory BCP-ALL, increasing age was associated with a decreasing decay coefficient of time-dependent clearance, reflecting that the target-mediated drug clearance declines more rapidly in children. In pediatric BCP-ALL, the median [interquartile range] cumulative area under the concentration–time curve was significantly higher among responders (n = 42) versus non-responders (n = 10) at the end of the first cycle (26.1 [18.9–35.0] vs 10.1 [9.19–16.1], × 10 3 ng*h/mL, p < 0.001). From simulations performed at the recommended pediatric phase II dose, inotuzumab ozogamicin exposure reached a similar level as observed in responding pediatric trial participants. Conclusions

Published
2024

10. Importance des anticorps dans la prise en charge de la greffe de cellules souches hématopoïétiques : anticorps anti-HLA, anti-plaquettes, anti-granuleux, anti-érythrocytes et anti-MICA. Recommandations de la Société francophone de greffe de moelle et de thérapie cellulaire (SFGM-TC)

Author

Delbos, Florent, Blouin, Laura, Bruno, Bénédicte, Crocchiolo, Roberto, Desoutter, Judith, Detrait, Marie, Nguyen-Lejarre, Khan Tien, Giannoli, Catherine, Lemarié, Claude, Renac, Virginie, Yakoub-Agha, Ibrahim, and Dubois, Valérie

Published
2020
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11. Greffe de cellules souches hématopoïétiques haplo-identiques avec cyclophosphamide en post-greffe : comment choisir le meilleur donneur en 2019 ? Recommandations de la Société francophone de greffe de mœlle et de thérapie cellulaire (SFGM-TC)

Author

Dubois, Valérie, Amokrane, Kahina, Beguin, Yves, Bruno, Bénédicte, Chevallier, Patrice, Delbos, Florent, Devillier, Raynier, Giannoli, Catherine, Guidicelli, Gwendaline, Harif, Mhamed, Loiseau, Pascale, Rouzaire, Paul-Olivier, Varlet, Pauline, Yakoub-Agha, Ibrahim, and Nguyen, Stéphanie

Published
2020
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12. Inotuzumab ozogamicin combined with chemotherapy in pediatric B-cell precursor CD22+ acute lymphoblastic leukemia: results of the phase IB ITCC-059 trial

Author

Pennesi, Edoardo, primary, Brivio, Erica, additional, Ammerlaan, Anneke C. J., additional, Jiang, Yilin, additional, Van der Velden, Vincent H. J., additional, Beverloo, H. Berna, additional, Sleight, Barbara, additional, Locatelli, Franco, additional, Brethon, Benoit, additional, Rossig, Claudia, additional, Engstler, Gernot, additional, Nilsson, Anna, additional, Bruno, Benedicte, additional, Petit, Arnaud, additional, Bielorai, Bella, additional, Rizzari, Carmelo, additional, Rialland, Fanny, additional, Rubio-San-Simón, Alba, additional, Sirvent, Francisco J. Bautista, additional, Diaz-de-Heredia, Cristina, additional, Rives, Susana, additional, and Zwaan, Christian M., additional

Published
2024
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13. Transfusion dans l’autogreffe et l’allogreffe de cellules souches hématopoïétiques chez l’adulte et l’enfant : recommandations de la Société francophone de greffe de moelle et de thérapie cellulaire (SFGM-TC)

Author

Giraud, Christine, Thibert, Jean-Baptiste, Desbrosses, Yohan, Debiol, Bénédicte, Alsuliman, Tamim, Bardiaux, Laurent, Garban, Frédéric, Huynh, Thi Ngoc Phuong, Samsonova, Olga, Yakoub-Agha, Ibrahim, and Bruno, Bénédicte

Published
2019
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14. Interest of Cytoreductive Therapy before Allogenic Hematopoietic Stem Cell Transplantation in Childhood Myelodysplastic Syndromes: A Retrospective Study on Behalf of the Société Francophone De Greffe De Moelle Et De Thérapie Cellulaire (SFGM-TC)

Author

Le Calvez, Baptiste, primary, Jullien, Maxime, additional, Dalle, Jean-Hugues, additional, Renard, Cécile, additional, Jubert, Charlotte, additional, Sterin, Arthur, additional, Paillard, Catherine, additional, Huynh, Anne, additional, Guenounou, Sarah, additional, Bruno, Benedicte, additional, Gandemer, Virginie, additional, Buchbinder, Nimrod, additional, Simon, Pauline, additional, Pochon, Cecile, additional, Sirvent, Anne, additional, Plantaz, Dominique, additional, Kanold, Justyna, additional, Rialland Battisti, Fanny, additional, and Grain, Audrey, additional

Published
2023
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15. A landscape of germ line mutations in a cohort of inherited bone marrow failure patients

Author

Bluteau, Olivier, Sebert, Marie, Leblanc, Thierry, Peffault de Latour, Régis, Quentin, Samuel, Lainey, Elodie, Hernandez, Lucie, Dalle, Jean-Hugues, Sicre de Fontbrune, Flore, Lengline, Etienne, Itzykson, Raphael, Clappier, Emmanuelle, Boissel, Nicolas, Vasquez, Nadia, Da Costa, Mélanie, Masliah-Planchon, Julien, Cuccuini, Wendy, Raimbault, Anna, De Jaegere, Louis, Adès, Lionel, Fenaux, Pierre, Maury, Sébastien, Schmitt, Claudine, Muller, Marc, Domenech, Carine, Blin, Nicolas, Bruno, Bénédicte, Pellier, Isabelle, Hunault, Mathilde, Blanche, Stéphane, Petit, Arnaud, Leverger, Guy, Michel, Gérard, Bertrand, Yves, Baruchel, André, Socié, Gérard, and Soulier, Jean

Published
2018
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16. Single- vs double-unit cord blood transplantation for children and young adults with acute leukemia or myelodysplastic syndrome

Author

Michel, Gérard, Galambrun, Claire, Sirvent, Anne, Pochon, Cecile, Bruno, Benedicte, Jubert, Charlotte, Loundou, Anderson, Yakoub-Agha, Ibrahim, Milpied, Noel, Lutz, Patrick, Marie-Cardine, Aude, Gandemer, Virginie, Blaise, Didier, Michallet, Mauricette, Rialland, Fanny, Renard, Cecile, Oudin, Claire, Esmiol, Sophie, Seux, Mylene, Baumstarck, Karine, Mohty, Mohamad, Rocha, Vanderson, and Dalle, Jean-Hugues

Published
2016
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17. Real-world use of defibrotide for veno-occlusive disease/sinusoidal obstruction syndrome: the DEFIFrance Registry Study

Author

Mohty, Mohamad, primary, Blaise, Didier, additional, Peffault de Latour, Régis, additional, Labopin, Myriam, additional, Bourhis, Jean Henri, additional, Bruno, Benedicte, additional, Ceballos, Patrice, additional, Detrait, Marie, additional, Gandemer, Virginie, additional, Huynh, Anne, additional, Izadifar-Legrand, Faezeh, additional, Jubert, Charlotte, additional, Labussière-Wallet, Hélène, additional, Lebon, Delphine, additional, Maury, Sébastien, additional, Paillard, Catherine, additional, Pochon, Cécile, additional, Renard, Cecile, additional, Rialland, Fanny, additional, Schneider, Pascale, additional, Sirvent, Anne, additional, Asubonteng, Kobby, additional, Guindeuil, Gwennaëlle, additional, Yakoub-Agha, Ibrahim, additional, and Dalle, Jean-Hugues, additional

Published
2022
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18. Inotuzumab Ozogamicin (InO) Combined with UKALL-R3 Modified Chemotherapy in Pediatric Patients with B-Cell Precursor CD22+ Acute Lymphoblastic Leukemia (BCP-ALL) - Results from the ITCC-059 Phase 1B Trial

Author

Pennesi, Edoardo, Brivio, Erica, Ammerlaan, Anneke C.J., Jiang, Yilin, van der Velden, Vincent H.J., Beverloo, Berna, Sleight, Barbara, Rives, Susana, Díaz de Heredia Rubio, Cristina, Bautista Sirvent, Francisco J., Rubio-San-Simón, Alba, Rialland, Fanny, Rizzari, Carmelo, Bielorai, Bella, Petit, Arnaud, Bruno, Bénédicte, Øra, Ingrid, Nilsson, Anna, Engstler, Gernot, Rossig, Claudia, Brethon, Benoit, Locatelli, Franco, and Zwaan, Christian M.

Published
2022
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19. Population Pharmacokinetics of Inotuzumab Ozogamicin (InO) As Single Agent in Pediatric Relapsed/Refractory Acute Lymphoblastic Leukemia - Results from the ITCC-059 Phase IA and Phase II Trial

Author

Pennesi, Edoardo, Brivio, Erica, Pelletier, Kathleen B., Chen, Ying, Huitema, Alwin D.R., Jiang, Yilin, Ammerlaan, Anneke C.J., Sleight, Barbara, Locatelli, Franco, Van Der Sluis, Inge M., Rossig, Claudia, Chen-Santel, Christiane, Bielorai, Bella, Petit, Arnaud, Stary, Jan, Sramkova, Lucie, Díaz de Heredia Rubio, Cristina, Rives, Susana, O'Marcaigh, Aengus, Rizzari, Carmelo, Engstler, Gernot, Nysom, Karsten, Rubio-San-Simón, Alba, Bautista Sirvent, Francisco J., Bruno, Bénédicte, Bertrand, Yives, Brethon, Benoit, Rialland, Fanny, Plat, Genevieve, Dirksen, Uta, Garrett, May, and Zwaan, Christian M.

Published
2022
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20. Ruxolitinib in Pediatric Patients with Treatment-Naïve or Steroid-Refractory Acute Graft-Versus-Host Disease: Primary Findings from the Phase I/II REACH4 Study

Author

Locatelli, Franco, Kang, Hyoung Jin, Bruno, Bénédicte, Gandemer, Virginie, Rialland, Fanny, Faraci, Maura, Takahashi, Yoshiyuki, Koh, Katsuyoshi, Bittencourt, Henrique, Cleary, Grace, Rosko, Christine, Roussou, Pantelia, St. Pierre, Annie, Prahallad, Anirudh, and Díaz-de-Heredia, Cristina

Published
2022
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21. Inotuzumab ozogamicin as single agent in pediatric patients with relapsed and refractory acute lymphoblastic leukemia:results from a phase II trial

Author

Pennesi, Edoardo, Michels, Naomi, Brivio, Erica, van der Velden, Vincent H.J., Jiang, Yilin, Thano, Adriana, Ammerlaan, Anneke J.C., Boer, Judith M., Beverloo, H. Berna, Sleight, Barbara, Chen, Ying, Vormoor-Bürger, Britta, Rives, Susana, Bielorai, Bella, Rössig, Claudia, Petit, Arnaud, Rizzari, Carmelo, Engstler, Gernot, Starý, Jan, Bautista Sirvent, Francisco J., Chen-Santel, Christiane, Bruno, Benedicte, Bertrand, Yves, Rialland, Fanny, Plat, Geneviève, Reinhardt, Dirk, Vinti, Luciana, Von Stackelberg, Arend, Locatelli, Franco, Zwaan, Christian M., Pennesi, Edoardo, Michels, Naomi, Brivio, Erica, van der Velden, Vincent H.J., Jiang, Yilin, Thano, Adriana, Ammerlaan, Anneke J.C., Boer, Judith M., Beverloo, H. Berna, Sleight, Barbara, Chen, Ying, Vormoor-Bürger, Britta, Rives, Susana, Bielorai, Bella, Rössig, Claudia, Petit, Arnaud, Rizzari, Carmelo, Engstler, Gernot, Starý, Jan, Bautista Sirvent, Francisco J., Chen-Santel, Christiane, Bruno, Benedicte, Bertrand, Yves, Rialland, Fanny, Plat, Geneviève, Reinhardt, Dirk, Vinti, Luciana, Von Stackelberg, Arend, Locatelli, Franco, and Zwaan, Christian M.

Abstract

Inotuzumab Ozogamicin is a CD22-directed antibody conjugated to calicheamicin, approved in adults with relapsed or refractory (R/R) B cell acute lymphoblastic leukemia (BCP-ALL). Patients aged 1–18 years, with R/R CD22 + BCP-ALL were treated at the RP2D of 1.8 mg/m2. Using a single-stage design, with an overall response rate (ORR) ≤ 30% defined as not promissing and ORR > 55% as expected, 25 patients needed to be recruited to achieve 80% power at 0.05 significance level. Thirty-two patients were enrolled, 28 were treated, 27 were evaluable for response. The estimated ORR was 81.5% (95%CI: 61.9–93.7%), and 81.8% (18/22) of the responding subjects were minimal residual disease (MRD) negative. The study met its primary endpoint. Median follow up of survivors was 16 months (IQR: 14.49–20.07). One year Event Free Survival was 36.7% (95% CI: 22.2–60.4%), and Overall Survival was 55.1% (95% CI: 39.1−77.7%). Eighteen patients received consolidation (with HSCT and/or CAR T-cells therapy). Sinusoidal obstructive syndrome (SOS) occurred in seven patients. MRD negativity seemed correlated to calicheamicin sensitivity in vitro, but not to CD22 surface expression, saturation, or internalization. InO was effective in this population. The most relevant risk was the occurrence of SOS, particularly when InO treatment was followed by HSCT.

Published
2022

22. Risk factors for a severe form of COVID-19 after allogeneic haematopoietic stem cell transplantation: a Société Francophone de Greffe de Moelle et de Thérapie cellulaire (SFGM-TC) multicentre cohort study.

Author

UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Centre du cancer, UCL - (SLuc) Service d'hématologie, Xhaard, Alienor, Xhaard, Constance, D'Aveni, Maud, Salvator, Helene, Chabi, Marie-Laure, Berceanu, Ana, Coman, Tereza, Beguin, Yves, Chalandon, Yves, Poiré, Xavier, Loschi, Michaël, Paillard, Catherine, Bruno, Benedicte, Ceballos, Patrice, Dalle, Jean-Hugues, Bilger, Karin, Bay, Jacques-Olivier, Robin, Marie, N'Guyen-Quoc, Stephanie, Rubio, Marie-Therese, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Centre du cancer, UCL - (SLuc) Service d'hématologie, Xhaard, Alienor, Xhaard, Constance, D'Aveni, Maud, Salvator, Helene, Chabi, Marie-Laure, Berceanu, Ana, Coman, Tereza, Beguin, Yves, Chalandon, Yves, Poiré, Xavier, Loschi, Michaël, Paillard, Catherine, Bruno, Benedicte, Ceballos, Patrice, Dalle, Jean-Hugues, Bilger, Karin, Bay, Jacques-Olivier, Robin, Marie, N'Guyen-Quoc, Stephanie, and Rubio, Marie-Therese

Abstract

No abstract available

Published
2021

23. Stem Cell Transplantation for Diamond–Blackfan Anemia. A Retrospective Study on Behalf of the Severe Aplastic Anemia Working Party of the European Blood and Marrow Transplantation Group (EBMT)

Author

Miano, Maurizio, Eikema, Dirk Jan, de la Fuente, Josu, Bosman, Paul, Ghavamzadeh, Ardeshir, Smiers, Frans, Sengeløv, Henrik, Yesilipek, Akif, Formankova, Renata, Bader, Peter, Díaz Pérez, Miguel Ángel, Bertrand, Yves, Niemeyer, Charlotte, Diallo, Safiatou, Ansari, Marc, Bykova, Tatiana A., Faraci, Maura, Bonanomi, Sonia, Gozdzik, Jolanta, Satti, Tariq Mahmood, Bodova, Ivana, Wölfl, Matthias, Rocha, Vanderson G., Mellgren, Karin, Rascon, Jelena, Holter, Wolfgang, Lange, Andrzej, Meisel, Roland, Beguin, Yves, Mozo, Yasmina, Kriván, Gergely, Sirvent, Anne, Bruno, Benedicte, Dalle, Jean Hugues, Onofrillo, Daniela, Giardino, Stefano, Risitano, Antonio M., de Latour, Régis Peffault, Dufour, Carlo, Miano, Maurizio, Eikema, Dirk Jan, de la Fuente, Josu, Bosman, Paul, Ghavamzadeh, Ardeshir, Smiers, Frans, Sengeløv, Henrik, Yesilipek, Akif, Formankova, Renata, Bader, Peter, Díaz Pérez, Miguel Ángel, Bertrand, Yves, Niemeyer, Charlotte, Diallo, Safiatou, Ansari, Marc, Bykova, Tatiana A., Faraci, Maura, Bonanomi, Sonia, Gozdzik, Jolanta, Satti, Tariq Mahmood, Bodova, Ivana, Wölfl, Matthias, Rocha, Vanderson G., Mellgren, Karin, Rascon, Jelena, Holter, Wolfgang, Lange, Andrzej, Meisel, Roland, Beguin, Yves, Mozo, Yasmina, Kriván, Gergely, Sirvent, Anne, Bruno, Benedicte, Dalle, Jean Hugues, Onofrillo, Daniela, Giardino, Stefano, Risitano, Antonio M., de Latour, Régis Peffault, and Dufour, Carlo

Abstract

Data on stem cell transplantation (SCT) for Diamond–Blackfan Anemia (DBA) is limited. We studied patients transplanted for DBA and registered in the EBMT database. Between 1985 and 2016, 106 DBA patients (median age, 6.8 years) underwent hematopoietic stem cell transplantation from matched-sibling donors (57%), unrelated donors (36%), or other related donors (7%), using marrow (68%), peripheral blood stem cells (20%), both marrow and peripheral blood stem cells (1%), or cord blood (11%). The cumulative incidence of engraftment was 86% (80% to 93%), and neutrophil recovery and platelet recovery were achieved on day +18 (range, 16 to 20) and +36 (range, 32 to 43), respectively. Three-year overall survival and event-free survival were 84% (77% to 91%) and 81% (74% to 89%), respectively. Older patients were significantly more likely to die (hazard ratio, 1.4; 95% confidence interval, 1.06 to 1.23; P <.001). Outcomes were similar between sibling compared to unrelated-donor transplants. The incidence of acute grades II to IV of graft-versus-host disease (GVHD) was 30% (21% to 39%), and the incidence of extensive chronic GVHD was 15% (7% to 22%). This study shows that SCT may represent an alternative therapeutic option for transfusion-dependent younger patients.

Published
2021

24. Stem Cell Transplantation for Diamond–Blackfan Anemia. A Retrospective Study on Behalf of the Severe Aplastic Anemia Working Party of the European Blood and Marrow Transplantation Group (EBMT)

Author

Miano, Maurizio, primary, Eikema, Dirk-Jan, additional, de la Fuente, Josu, additional, Bosman, Paul, additional, Ghavamzadeh, Ardeshir, additional, Smiers, Frans, additional, Sengeløv, Henrik, additional, Yesilipek, Akif, additional, Formankova, Renata, additional, Bader, Peter, additional, Díaz Pérez, Miguel Ángel, additional, Bertrand, Yves, additional, Niemeyer, Charlotte, additional, Diallo, Safiatou, additional, Ansari, Marc, additional, Bykova, Tatiana A, additional, Faraci, Maura, additional, Bonanomi, Sonia, additional, Gozdzik, Jolanta, additional, Satti, Tariq Mahmood, additional, Bodova, Ivana, additional, Wölfl, Matthias, additional, Rocha, Vanderson G., additional, Mellgren, Karin, additional, Rascon, Jelena, additional, Holter, Wolfgang, additional, Lange, Andrzej, additional, Meisel, Roland, additional, Beguin, Yves, additional, Mozo, Yasmina, additional, Kriván, Gergely, additional, Sirvent, Anne, additional, Bruno, Benedicte, additional, Dalle, Jean Hugues, additional, Onofrillo, Daniela, additional, Giardino, Stefano, additional, Risitano, Antonio M., additional, de Latour, Régis Peffault, additional, and Dufour, Carlo, additional

Published
2021
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25. [Haploidentical hematopoietic stem cell transplant: How to choose the best donor? Guidelines from the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)]

Author

Dubois, Valérie, Amokrane, Kahina, Beguin, Yves, Bruno, Benedicte, Chevallier, Patrice, Delbos, Florent, Devillier, Raynier, Giannoli, Catherine, Guidicelli, Gwendaline, Harif, Mhamed, Loiseau, Pascale, Rouzaire, Paul-Olivier, Varlet, Pauline, Yakoub-Agha, Ibrahim, Nguyen, Stephanie, Etablissement français du sang - Auvergne-Rhône-Alpes (EFS), Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service d'Hématologie, Université de Liège, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Immunobiology of Human αβ and γδ T Cells and Immunotherapeutic Applications (CRCINA-ÉQUIPE 1), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes), Laboratoire d'Histocompatibilité et d'Immunogénétique [EFS Nantes], Etablissement Français du Sang [Nantes], Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Etablissement français du sang- Rhône-Alpes [Lyon], Service d'immunologie et d'immunogénétique [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux], Immunogénétique humaine, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Clermont-Ferrand, Imagerie Moléculaire et Stratégies Théranostiques (IMoST), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Centre Hospitalier Universitaire de Lille (CHU de Lille), Department of Microbiology and Immunology, East Carolina University [Greenville] (ECU), University of North Carolina System (UNC)-University of North Carolina System (UNC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Aix Marseille Université (AMU), and Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Adult, Graft Rejection, Male, Transplantation Conditioning, Haploidentical transplantation, T-Lymphocytes, [SDV]Life Sciences [q-bio], [SDV.CAN]Life Sciences [q-bio]/Cancer, DSA, Lymphocyte Depletion, Sex Factors, HLA Antigens, Donor choice, Humans, Greffe haplo-identique, Cyclophosphamide, Bone Marrow Transplantation, Histocompatibility Testing, Graft Survival, Age Factors, Hematopoietic Stem Cell Transplantation, Allografts, Tissue Donors, Haplotypes, Histocompatibility, Cytomegalovirus Infections, Female, Choix du donneur, Immunosuppressive Agents
Abstract

International audience; Haploidentical hematopoietic stem cell transplantation has been growing steadily since 2012. The SFGM-TC has twice published guidelines concerning T-cell repleted haploidentical grafts with high dose cyclophosphamide post-transplantation. The 2013 workshop recommended using the non-myeloablative Baltimore protocol with bone marrow and developed prospective protocols to evaluate these transplantations. The 2015 workshop reported improved results of reduced conditioning regimens in Hodgkin's lymphoma and intensive conditioning in myeloid hemopathies, and a similar outcome with 10/10 HLA matched donor with the same disease-risk score thus raising the question of the qualifier "alternative" for haploidentical transplants. The current work concerns the criteria for selecting the donor. The main criterion remains the absence of anti-HLA antibodies directed against the donor present in the recipient sera (DSA - Donor Specific Antibodies). In case of DSA and in the absence of an alternative donor, desensitization protocols exist. The other criteria are impossible to prioritize: age, sex, CMV, and blood type. The degree of relatedness and the number of HLA incompatibilities do not seem to be a criterion of choice. The 'ideal' donor would be a young man, CMV-matched, without major ABO incompatibility with a marrow transplant. There is insufficient data for the KIR-ligand and NIMA/NIPA mismatch. Peripheral stem cell grafts appear to yield more acute GVHD than bone marrow grafts after intensive conditioning, but with comparable survival rates. Based on the literature review, the comparison of haploidentical with unrelated donors encourages inclusion in existing national protocols randomizing these different donors.

Published
2020

26. Risk factors for a severe form of COVID‐19 after allogeneic haematopoietic stem cell transplantation: a Société Francophone de Greffe de Moelle et de Thérapie cellulaire (SFGM‐TC) multicentre cohort study

Author

Xhaard, Alienor, primary, Xhaard, Constance, additional, D’Aveni, Maud, additional, Salvator, Helene, additional, Chabi, Marie‐Laure, additional, Berceanu, Ana, additional, Coman, Tereza, additional, Beguin, Yves, additional, Chalandon, Yves, additional, Poiré, Xavier, additional, Loschi, Michaël, additional, Paillard, Catherine, additional, Bruno, Benedicte, additional, Ceballos, Patrice, additional, Dalle, Jean‐Hugues, additional, Bilger, Karin, additional, Bay, Jacques‐Olivier, additional, Robin, Marie, additional, N’Guyen‐Quoc, Stephanie, additional, and Rubio, Marie‐Therese, additional

Published
2021
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28. Assessment of chimerism and immunomodulation to prevent post-transplantation relapse in childhood acute myeloblastic leukemia: is it the right approach?

Author

Cousin, Elie, primary, Oger, Emmanuel, additional, Dalle, Jean-Hugues, additional, Bertrand, Yves, additional, Pertuisel, Sophie, additional, Pochon, Cecile, additional, Galambrun, Claire, additional, Simon, Pauline, additional, Bruno, Benedicte, additional, Paillard, Catherine, additional, Schneider, Pascale, additional, Rohrlich, Pierre, additional, de La Tour, Régis Peffault, additional, Freycon, Claire, additional, Eliaou, Jean-Francois, additional, Semana, Gilbert, additional, Jonveaux, Philippe, additional, Drunat, Severine, additional, Bordigoni, Pierre, additional, and Gandemer, Virginie, additional

Published
2020
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29. Unrelated cord blood transplantation in patients with idiopathic refractory severe aplastic anemia: a nationwide phase 2 study

Author

Peffault de Latour, Regis, Chevret, Sylvie, Jubert, Charlotte, Sirvent, Anne, Galambrun, Claire, Ruggeri, Annalisa, Gandemer, Virginie, Cornillon, Jérôme, Rialland, Fanny, Dalle, Jean-Hugues, Forcade, Edouard, Bruno, Benedicte, Paillard, Catherine, Rorlich, Pierre S., Salmon, Alexandra, Fürst, Sabine, Sicre de Fontbrune, Flore, Rubio, Marie Therese, Bay, Jacques-Olivier, Mohty, Mohamad, Larghero, Jerome, Gluckman, Eliane, Socié, Gerard, and on behalf of the Francophone Society of Bone Marrow Transplantation and Cellular Therapy

Published
2018
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30. Stem Cell Transplantation for Diamond-Blackfan Anemia. a Retrospective Study on Behalf of Severe Aplastic Anemia Working Party of the European Blood and Marrow Transplantation Group (EBMT)

Author

Miano, Maurizio, primary, Eikema, Dirk-Jan, primary, de la Fuente, Josu, primary, Bosman, Paul, primary, Ghavamzadeh, Ardeshir, primary, Smiers, Frans, primary, Sengeløv, Henrik, primary, Yesilipek, Akif, primary, Formankova, Renata, primary, Bader, Peter, primary, Díaz Pérez, Miguel Ángel, primary, Bertrand, Yves, primary, Niemeyer, Charlotte, primary, Bron, Dominique, primary, Ansari, Marc, primary, Bykova, Tatiana A, primary, Lanino, Edoardo, primary, Rovelli, Attilio, primary, Gozdzik, Jolanta, primary, Satti, Tariq Mahmood, primary, Bodova, Ivana, primary, Wölfl, Matthias, primary, Rocha, Vanderson G., primary, Mellgren, Karin, primary, Rascon, Jelena, primary, Lange, Andrzej, primary, Meisel, Roland, primary, Beguin, Yves, primary, Mozo, Yasmina, primary, Kriván, Gergely, primary, Sirvent, Anne, primary, Bruno, Benedicte, primary, Onofrillo, Daniela, primary, Risitano, Antonio M., primary, Peffault de Latour, Régis, primary, and Dufour, Carlo, primary

Published
2019
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31. Single-Unit versus Double-Unit Umbilical Cord Blood Transplantation in Children and Young Adults with Residual Leukemic Disease

Author

Balligand, Laura, primary, Galambrun, Claire, additional, Sirvent, Anne, additional, Roux, Clémence, additional, Pochon, Cecile, additional, Bruno, Benedicte, additional, Jubert, Charlotte, additional, Loundou, Anderson, additional, Esmiol, Sophie, additional, Yakoub-Agha, Ibrahim, additional, Forcade, Edouard, additional, Paillard, Catherine, additional, Marie-Cardine, Aude, additional, Plantaz, Dominique, additional, Gandemer, Virginie, additional, Blaise, Didier, additional, Rialland, Fanny, additional, Renard, Cecile, additional, Seux, Mylene, additional, Baumstarck, Karine, additional, Mohty, Mohamad, additional, Dalle, Jean-Hugues, additional, and Michel, Gérard, additional

Published
2019
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32. Additional file 1: of Curative or pre-emptive adenovirus-specific T cell transfer from matched unrelated or third party haploidentical donors after HSCT, including UCB transplantations: a successful phase I/II multicenter clinical trial

Author

Chongsheng Qian, Campidelli, Arnaud, Yingying Wang, Huili Cai, Venard, Véronique, Jeulin, Hélène, Dalle, Jean, Pochon, Cécile, D’aveni, Maud, Bruno, Benedicte, Paillard, Catherine, Vigouroux, Stéphane, Jubert, Charlotte, Ceballos, Patrice, Marie-Cardine, Aude, Galambrun, Claire, Cholle, Clément, Urmes, Isabelle Clerc, Petitpain, Nadine, Bittencourt, Marcelo De Carvalho, Decot, Véronique, Reppel, Loïc, Salmon, Alexandra, Clement, Laurence, and Bensoussan, Danièle

Abstract

Online supplement. (DOCX 21 kb)

Published
2017
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33. Outcome of patients with Fanconi anemia developing myelodysplasia and acute leukemia who received allogeneic hematopoietic stem cell transplantation: A retrospective analysis on behalf of EBMT group.

Author

Giardino, Stefano, Latour, Regis P., Aljurf, Mahmoud, Eikema, Dirk‐Jan, Bosman, Paul, Bertrand, Yves, Tbakhi, Abdelghani, Holter, Wolfgang, Bornhäuser, Martin, Rössig, Claudia, Burkhardt, Birgit, Zecca, Marco, Afanasyev, Boris, Michel, Gerard, Ganser, Arnold, Alseraihy, Amal, Ayas, Mouhab, Uckan‐Cetinkaya, Duygu, Bruno, Benedicte, and Patrick, Katharine

Published
2020
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35. Busulfan/Fludarabine- or Treosulfan/Fludarabine-Based Conditioning Regimen in Patients with Wiskott-Aldrich Syndrome Given Allogeneic Hematopoietic Cell Transplantation — an EBMT Inborn Errors Working Party and Scetide Retrospective Analysis

Author

Albert, Michael H., primary, Slatter, Mary, additional, Gennery, Andrew, additional, Guengoer, Tayfun, additional, Blok, Henric-Jan, additional, Wang, Junfeng, additional, Courteille, Virginie, additional, Bernardo, Maria Ester, additional, Bodova, Ivana, additional, Bruno, Benedicte, additional, Bykova, Tatjana A, additional, Chiesa, Robert, additional, Fischer, Alain, additional, Formankova, Renata, additional, Kalwak, Krzysztof, additional, Klein, Christoph, additional, Kozlovskaya, Svetlana, additional, Kupesiz, O. Alphan, additional, Locatelli, Franco, additional, Mahlaoui, Nizar, additional, Moshous, Despina, additional, Neven, Benedicte, additional, Porta, Fulvio, additional, Schulz, Ansgar, additional, Sykora, Karl-Walter, additional, Unal, Ekrem, additional, Winiarski, Jacek H., additional, Zecca, Marco, additional, Veys, Paul, additional, and Lankester, Arjan, additional

Published
2018
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37. Curative or pre-emptive adenovirus-specific T cell transfer from matched unrelated or third party haploidentical donors after HSCT, including UCB transplantations: a successful phase I/II multicenter clinical trial

Author

Qian, Chongsheng, primary, Campidelli, Arnaud, additional, Wang, Yingying, additional, Cai, Huili, additional, Venard, Véronique, additional, Jeulin, Hélène, additional, Dalle, Jean Hugues, additional, Pochon, Cécile, additional, D’aveni, Maud, additional, Bruno, Benedicte, additional, Paillard, Catherine, additional, Vigouroux, Stéphane, additional, Jubert, Charlotte, additional, Ceballos, Patrice, additional, Marie-Cardine, Aude, additional, Galambrun, Claire, additional, Cholle, Clément, additional, Clerc Urmes, Isabelle, additional, Petitpain, Nadine, additional, De Carvalho Bittencourt, Marcelo, additional, Decot, Véronique, additional, Reppel, Loïc, additional, Salmon, Alexandra, additional, Clement, Laurence, additional, and Bensoussan, Danièle, additional

Published
2017
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38. Efficacy and Safety of Unrelated Cord Blood Transplantation in Patients with Acquired Refractory Aplastic Anemia: A Phase II Study on Behalf of Eurocord and the Francophone Society of Bone Marrow Transplantation and Cellular Therapy

Author

Peffault de Latour, Régis, primary, Chevret, Sylvie, additional, Jubert, Charlotte, additional, Sirvent, Anne, additional, Galambrun, Claire, additional, Ruggeri, Annalisa, additional, Gandemer, Virginie, additional, Cornillon, Jérôme, additional, Rialland, Fanny, additional, Dalle, Jean-Hugues, additional, Milpied, Noel, additional, Bruno, Benedicte, additional, Paillard, Catherine, additional, Legrand, Faezeh, additional, Salmon, Alexandra, additional, Furst, Sabine, additional, Rubio, Marie t, additional, Bay, Jacques-Olivier, additional, Mohty, Mohamad, additional, Larghero, Jerome, additional, Gluckman, Eliane, additional, and Socie, Gerard, additional

Published
2016
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39. Curative or pre-emptive adenovirus-specific T cell transfer from matched unrelated or third party haploidentical donors after HSCT, including UCB transplantations: a successful phase I/II multicenter clinical trial.

Author

Chongsheng Qian, Campidelli, Arnaud, Yingying Wang, Huili Cai, Venard, Véronique, Jeulin, Hélène, Jean Hugues Dalle, Pochon, Cécile, D'aveni, Maud, Bruno, Benedicte, Paillard, Catherine, Vigouroux, Stéphane, Jubert, Charlotte, Ceballos, Patrice, Marie-Cardine, Aude, Galambrun, Claire, Cholle, Clément, Urmes, Isabelle Clerc, Petitpain, Nadine, and De Carvalho Bittencourt, Marcelo

Subjects
HEMATOPOIETIC stem cell transplantation, T cells, IMMUNOMAGNETIC separation, CORD blood transplantation, BLOOD donors, GRAFT versus host disease, VIRAL disease treatment, THERAPEUTICS, PHYSIOLOGY
Abstract

Background: Allogeneic hematopoietic stem cell transplantation (HSCT), the most widely used potentially curable cellular immunotherapeutic approach in the treatment of hematological malignancies, is limited by life-threatening complications: graft versus host disease (GVHD) and infections especially viral infections refractory to antiviral drugs. Adoptive transfer of virus-specific T cells is becoming an alternative treatment for infections following HSCT. We report here the results of a phase I/II multicenter study which includes a series of adenovirus-specific T cell (ADV-VST) infusion either from the HSCT donor or from a third party haploidentical donor for patients transplanted with umbilical cord blood (UCB). Methods: Fourteen patients were eligible and 11 patients received infusions of ADV-VST generated by interferon (IFN)-γ-based immunomagnetic isolation from a leukapheresis from their original donor (42.9%) or a third party haploidentical donor (57.1%). One patient resolved ADV infection before infusion, and ADV-VST could not reach release or infusion criteria for two patients. Two patients received cellular immunotherapy alone without antiviral drugs as a pre-emptive treatment. Results: One patient with adenovirus infection and ten with adenovirus disease were infused with ADV-VST (mean 5.83 ± 8.23 × 10>3 CD3+IFN-γ+ cells/kg) up to 9 months after transplantation. The 11 patients showed in vivo expansion of specific T cells up to 60 days post-infusion, associated with adenovirus load clearance in ten of the patients (91%). Neither de novo GVHD nor side effects were observed during the first month post-infusion, but GVHD reactivations occurred in three patients, irrespective of the type of leukapheresis donor. For two of these patients, GVHD reactivation was controlled by immunosuppressive treatment. Four patients died during follow-up, one due to refractory ADV disease. Conclusions: Adoptive transfer of rapidly isolated ADV-VST is an effective therapeutic option for achieving in vivo expansion of specific T cells and clearance of viral load, even as a pre-emptive treatment. Our study highlights that third party haploidentical donors are of great interest for ADV-VST generation in the context of UCB transplantation. (N° Clinical trial.gov: NCT02851576, retrospectively registered). [ABSTRACT FROM AUTHOR]

Published
2017
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44. Outcome of Busulfan and Fludarabine-Based Reduced Intensity Conditioning Regimen for Related and Unrelated HSCT in Fanconi Anemia Patients

Author

Azarnoush, Saba, primary, Porcher, Raphael, additional, de la Tour, Regis Peffault, additional, Yakouben, Karima, additional, Bruno, Benedicte, additional, Chardin, Marie Ouachee, additional, Robin, Marie, additional, Baruchel, Andre, additional, Socie, Gerard, additional, and Dalle, Jean-Hugues, additional

Published
2011
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45. Reduced-Intensity Allogeneic Hematopoietic Stem Cell Transplantation: Results of a Prospective Multicenter Open French Study In High-Risk pediatrics

Author

Paillard, Catherine, primary, Lutz, Patrick, additional, Leverger, Guy, additional, Michel, Gerard, additional, Bordigoni, Pierre, additional, Dalle, Jean-Hugues, additional, Bertrand, Yves, additional, Sirvent, Anne, additional, Rohrlich, Pierre, additional, Vannier, Jean-Pierre, additional, Plantaz, Dominique, additional, Jubert, Charlotte, additional, Bruno, Benedicte, additional, Gandemer, Virginie, additional, Dore, Eric, additional, Isfan, Florentina, additional, Merlin, Etienne, additional, Rochette, Emmanuelle, additional, Halle, Pascale, additional, Demeocq, Francois, additional, and Kanold, Justyna, additional

Published
2010
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48. Immune Reconstitution Following Myeloablative Allogeneic Hematopoietic Stem Cell Transplantation: The Impact of Expanding CD28negCD8+ T-Cells on Relapse.

Author

Yakoub-Agha, Ibrahim, primary, Saule, Pasquine, primary, Salleron, Julia, primary, Cracco, Pascale, primary, Coiteux, Valerie, primary, Magro, Leonardo, primary, Dufosse, Francoise, primary, Bruno, Benedicte, primary, Jouet, Jean-Pierre, primary, Duhamel, Alain, primary, Dessaint, Jean-Paul, primary, and Labalette, Myriam, primary

Published
2008
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49. Proportions of T-Cell CD8+ Subsets Lacking CD28 Expression at Day 30 after Myeloablative Allogeneic Stem Cell Transplantation Are Predictive for Relapse and Chronic GVHD.

Author

Yakoub-Agha, Ibrahim, primary, Saule, Pasquine, additional, Magro, Leonardo, additional, Cracco, Pascale, additional, Coiteux, Valerie, additional, Bruno, Benedicte, additional, Cliquennois, Manuel, additional, Dufosse, Francoise, additional, Jouet, Jean-Pierre, additional, Dessaint, Jean-Paul, additional, and Labalette, Myriam, additional

Published
2007
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50. Efficacy of the Combination of Gemtuzumab-Ozogamicin (Mylotarg(R)) and Cytarabine (GOCYT) in Childhood Myeloid Leukemia: A Compassionate Use Based Review in France.

Author

Brethon, Benoit, primary, Yakouben, Karima, additional, Oudot, Caroline, additional, Boutard, Patrick, additional, Bruno, Benedicte, additional, Jerome, Cecile, additional, Nelken, Brigitte, additional, de Lumley, Lionel, additional, Bertrand, Yves, additional, Dalle, Jean-Hugues, additional, Leblanc, Thierry, additional, and Baruchel, Andre, additional

Published
2006
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