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226 results on '"Brunkhorst, F. M."'

1. Prevention, diagnosis, therapy and follow-up care of sepsis: 1st revision of S-2k guidelines of the German Sepsis Society (Deutsche Sepsis-Gesellschaft e.V. (DSG)) and the German Interdisciplinary Association of Intensive Care and Emergency Medicine (Deutsche Interdisziplinäre Vereinigung für Intensiv- und Notfallmedizin (DIVI))

Author

Reinhart, K., Brunkhorst, F. M., Bone, H.-G., Bardutzky, J., Dempfle, C.-E., Forst, H., Gastmeier, P., Gerlach, H., Gründling, M., John, S., Kern, W., Kreymann, G., Krüger, W., Kujath, P., Marggraf, G., Martin, J., Mayer, K., Meier-Hellmann, A., Oppert, M., Putensen, C., Quintel, M., Ragaller, M., Rossaint, R., Seifert, H., Spies, C., Stüber, F., Weiler, N., Weimann, A., Werdan, K., and Welte, T.

Subjects
guideline, German Sepsis Society, German Sepsis Aid, severe sepsis, septic shock, prevention, diagnosis, treatment, follow-up care, Medicine
Abstract

Practice guidelines are systematically developed statements and recommendations that assist the physicians and patients in making decisions about appropriate health care measures for specific clinical circumstances taking into account specific national health care structures. The 1st revision of the S-2k guideline of the German Sepsis Society in collaboration with 17 German medical scientific societies and one self-help group provides state-of-the-art information (results of controlled clinical trials and expert knowledge) on the effective and appropriate medical care (prevention, diagnosis, therapy and follow-up care) of critically ill patients with severe sepsis or septic shock. The guideline had been developed according to the “German Instrument for Methodological Guideline Appraisal” of the Association of the Scientific Medical Societies (AWMF). In view of the inevitable advancements in scientific knowledge and technical expertise, revisions, updates and amendments must be periodically initiated. The guideline recommendations may not be applied under all circumstances. It rests with the clinician to decide whether a certain recommendation should be adopted or not, taking into consideration the unique set of clinical facts presented in connection with each individual patient as well as the available resources.

Published
2010

2. International registry on the use of the CytoSorb® adsorber in ICU patients: Study protocol and preliminary results

Author

Friesecke, S., Träger, K., Schittek, G. A., Molnar, Z., Bach, F., Kogelmann, K., Bogdanski, R., Weyland, A., Nierhaus, A., Nestler, F., Olboeter, D., Tomescu, D., Jacob, D., Haake, H., Grigoryev, E., Nitsch, M., Baumann, A., Quintel, M., Schott, M., Kielstein, J. T., Meier-Hellmann, A., Born, F., Schumacher, U., Singer, M., Kellum, J., and Brunkhorst, F. M.

Published
2019
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14. Delay in the administration of appropriate antimicrobial therapy in Staphylococcus aureus bloodstream infection: a prospective multicenter hospital-based cohort study

Author

Kaasch, A. J., Rieg, S., Kuetscher, J., Brodt, H.-R., Widmann, T., Herrmann, M., Meyer, C., Welte, T., Kern, P., Haars, U., Reuter, S., Hübner, I., Strauss, R., Sinha, B., Brunkhorst, F. M., Hellmich, M., Fätkenheuer, G., Kern, W. V., Seifert, H., and The preSABATO study group*

Published
2013
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17. Diagnose und Therapie der Sepsis: S-2 Leitlinien der Deutschen Sepsis-Gesellschaft e. V. (DSG) und der Deutschen Interdisziplinären Vereinigung für Intensiv- und Notfallmedizin (DIVI) *: Teil 2

Author

Reinhart, K., Brunkhorst, F. M., Bone, H.-G., Gerlach, H., Gründling, M., Kreymann, G., Kujath, P., Marggraf, G., Mayer, K., Meier-Hellmann, A., Peckelsen, C., Putensen, C., Stüber, F., Quintel, M., Ragaller, M., Rossaint, R., Weiler, N., Welte, T., and Werdan, K.

Published
2006
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18. Diagnose und Therapie der Sepsis: S-2 Leitlinien der Deutschen Sepsis-Gesellschaft e.V. (DSG) und der Deutschen Interdisziplinären Vereinigung für Intensiv- und Notfallmedizin (DIVI)*

Author

Reinhart, K., Brunkhorst, F. M., Bone, H.-G., Gerlach, H., Gründling, M., Kreymann, G., Kujath, P., Marggraf, G., Mayer, K., Meier-Hellmann, A., Peckelsen, C., Putensen, C., Stüber, F., Quintel, M., Ragaller, M., Rossaint, R., Weiler, N., Welte, T., and Werdan, K.

Published
2006
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20. Diagnose und Therapie der Sepsis: S-2 Leitlinien der Deutschen Sepsis-Gesellschaft e. V. (DSG) und der Deutschen Interdisziplinären Vereinigung für Intensiv- und Notfallmedizin (DIVI)*: Teil 1

Author

Reinhart, K., Brunkhorst, F. M., Bone, H.-G., Gerlach, H., Gründling, M., Kreymann, G., Kujath, P., Marggraf, G., Mayer, K., Meier-Hellmann, A., Peckelsen, C., Putensen, C., Stüber, F., Quintel, M., Ragaller, M., Rossaint, R., Weiler, N., Welte, T., and Werdan, K.

Published
2006
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21. Diagnose und Therapie der Sepsis: S2-Leitlinien der Deutschen Sepsis-Gesellschaft e.V. (DSG) und der Deutschen Interdisziplinären Vereinigung für Intensiv- und Notfallmedizin (DIVI)

Author

Reinhart, K., Brunkhorst, F. M., Bone, H. G., Gerlach, H., Gründling, M., Kreymann, G., Kujath, P., Marggraf, G., Mayer, K., Meier-Hellmann, A., Peckelsen, C., Putensen, C., Quintel, M., Ragaller, M., Rossaint, R., Stüber, F., Weiler, N., Welte, T., and Werdan, K.

Published
2006
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27. Sepsis-3

Author

David, S. and Brunkhorst, F. M.

Subjects
Scores des Organversagens, Schwerpunkt: Was ist gesichert in der Therapie?, Organ Dysfunction Scores, Multiple Organ Failure, Guideline, Combined Modality Therapy, Shock, Septic, Systemic Inflammatory Response Syndrome, Survival Rate, Fluid therapy, Anti-Infective Agents, Septic shock, Sepsis, Septischer Schock, Syndrom der systemischen Inflammationsreaktion, Humans, Guideline Adherence, Flüssigkeitstherapie, Leitlinie
Abstract

Zusammenfassung Hugo Schottmüller erkannte bereits vor über 100 Jahren, dass es sich bei der Sepsis um ein Syndrom handelt, bei dem nicht die Infektion an sich, sondern eine Überreaktion des Organismus auf eine periodische Einschwemmung von Krankheitserregern unsere Patienten schädigt. Vor etwa 25 Jahren wurde entsprechend diesem Konzept der Begriff des Syndroms der systemischen Inflammationsreaktion („systemic inflammatory response syndrome“ [SIRS]) geprägt. Er wird im klinischen Alltag quasi ständig gebraucht. Im Jahr 2016 hat sich eine Expertenkommission bemüht, eine dritte Sepsisdefinition (Sepsis-3) zu erstellen, die auf wissenschaftlichen Daten beruhen sollte. In den Vordergrund rückt nun die fehlregulierte Wirtsantwort auf eine Infektion zusammen mit der Organdysfunktion als obligate Voraussetzung der Diagnosestellung. In diesem Beitrag wird die neue Definition im Detail erläutert. Zudem wird die Anfang des Jahres 2017 erschienene internationale Leitlinie zusammengefasst und kommentiert.

Published
2017

33. Poster Discussions

Author

López, J., Jiménez, M., Peláez, J., Arce, M. A., Asensio, M. J., Arnalich, F., Hernanz, A., Zweigner, J., Gramm, H. -J., Lamping, N., Kopf, A., Asmus, A., Schumann, R. R., Zimmermann, J., Meinhold, H., Beier, W., Wegscheider, K., Murphy, M., Catania, A., Cutuli, M., Garofalo, L., Valenza, F., Lipton, J. M., Berger, D., Boelke, E., Hiki, N., Lissner, R., Arnold, A., Hausmann, F., Seidelmann, M., Beger, H. G., Berger, D., Braunmueller, H. D., Bōlke, E., Schmidt, U., Ott, S., Seidelmann, H., Bohuon, C., Raymond, J., Assicot, M., Moulin, F., Bergeret, M., Lebon, P., Gendrei, D., Lantéri-Minet, M., Scoazec, J. Y., Dosquet, C., Beyne, P., Voitot, H., Mencia-Huerta, J. M., Lettéron, P., Lebrec, D., Lehmann, C. H., Egerer, K., Georgiew, A., Weber, M., Kox, W. J., Brunkhorst, F. M., Forycki, Z. F., Beier, W., Wagner, J., Orfanos, S. E., Armaganidis, A., Bardouniotou, H., Mavrommati, I., Catravas, J. D., Economidou, J., and Roussos, Ch.

Published
1996
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40. International registry on the use of the CytoSorb® adsorber in ICU patients

Author

Friesecke, S., primary, Träger, K., additional, Schittek, G. A., additional, Molnar, Z., additional, Bach, F., additional, Kogelmann, K., additional, Bogdanski, R., additional, Weyland, A., additional, Nierhaus, A., additional, Nestler, F., additional, Olboeter, D., additional, Tomescu, D., additional, Jacob, D., additional, Haake, H., additional, Grigoryev, E., additional, Nitsch, M., additional, Baumann, A., additional, Quintel, M., additional, Schott, M., additional, Kielstein, J. T., additional, Meier-Hellmann, A., additional, Born, F., additional, Schumacher, U., additional, Singer, M., additional, Kellum, J., additional, and Brunkhorst, F. M., additional

Published
2017
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44. [Prevention, diagnosis, treatment, and follow-up care of sepsis. First revision of the S2k Guidelines of the German Sepsis Society (DSG) and the German Interdisciplinary Association for Intensive and Emergency Care Medicine (DIVI)]

Author

Reinhart, K, Brunkhorst, F M, Bone, H-G, Bardutzky, J, Dempfle, C-E, Forst, H, Gastmeier, P, Gerlach, H, Gründling, M, John, S, Kern, W, Kreymann, G, Krüger, W, Kujath, P, Marggraf, G, Martin, J, Mayer, K, Meier-Hellmann, A, Oppert, M, Putensen, C, Quintel, M, Ragaller, M, Rossaint, R, Seifert, H, Spies, C, Stüber, F, Weiler, N, Weimann, A, Werdan, K, and Welte, T

Subjects
Infection Control, Sepsis, Terminology as Topic, Anti-Infective Agents, Local, Hemodynamics, Fluid Therapy, Humans, Pneumonia, Ventilator-Associated, Surgical Wound Infection, Infections, Decontamination, Anti-Bacterial Agents, Meningitis, Bacterial
Published
2010
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45. Prävention, Diagnose, Therapie und Nachsorge der Sepsis : 1. Revision der S-2k Leitlinien der Deutschen Sepsis-Gesellschaft e.V. (DSG) und der Deutschen Interdisziplinären Vereinigung für Intensiv- und Notfallmedizin (DIVI)

Author

Reinhart, K., Brunkhorst, F. M., Bone, H.-G., Bardutzky, J., Dempfle, C.-E., Forst, H., Gastmeier, P., Gerlach, H., Gründling, M., John, S., Kern, W., Kreymann, G., Krüger, W., Kujath, P., Marggraf, G., Martin, J., Mayer, K., Meier-Hellmann, A., Oppert, M., Putensen, C., Quintel, M., Ragaller, M., Rossaint, R., Seifert, H., Spies, C., Stüber, F., Weiler, N., Weimann, A., Werdan, K., and Welte, T.

Subjects
Emergency Medical Services, Critical Care, diagnosis, Medizin, lcsh:Medicine, Article, follow-up care, 03 medical and health sciences, 0302 clinical medicine, prevention, Germany, Sepsis, Humans, 030212 general & internal medicine, Patient Care Team, treatment, lcsh:R, Intensive Care, 610 Medical sciences, Medicine, Continuity of Patient Care, 3. Good health, severe sepsis, German Sepsis Aid, 030220 oncology & carcinogenesis, septic shock, guideline, German Sepsis Society, Follow-Up Studies
Abstract

Practice guidelines are systematically developed statements and recommendations that assist the physicians and patients in making decisions about appropriate health care measures for specific clinical circumstances taking into account specific national health care structures. The 1st revision of the S-2k guideline of the German Sepsis Society in collaboration with 17 German medical scientific societies and one self-help group provides state-of-the-art information (results of controlled clinical trials and expert knowledge) on the effective and appropriate medical care (prevention, diagnosis, therapy and follow-up care) of critically ill patients with severe sepsis or septic shock. The guideline had been developed according to the “German Instrument for Methodological Guideline Appraisal” of the Association of the Scientific Medical Societies (AWMF). In view of the inevitable advancements in scientific knowledge and technical expertise, revisions, updates and amendments must be periodically initiated. The guideline recommendations may not be applied under all circumstances. It rests with the clinician to decide whether a certain recommendation should be adopted or not, taking into consideration the unique set of clinical facts presented in connection with each individual patient as well as the available resources., GMS German Medical Science; 8:Doc14; ISSN 1612-3174

Published
2010
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46. [Study protocol of the VISEP study. Response of the SepNet study group]

Author

Reinhart, K, Brunkhorst, F M, Engel, C, Bloos, F, Meier-Hellmann, A, Ragaller, M, Weiler, N, Moerer, O, Gruendling, M, Oppert, M, Grond, S, Olthoff, D, Jaschinski, U, John, S, Rossaint, R, Welte, T, Schaefer, M, Kern, P, Kuhnt, E, Kiehntopf, M, Deufel, T, Hartog, C, Gerlach, H, Stüber, F, Volk, H-D, Quintel, M, and Loeffler, M

Abstract

In the commentary by Zander et al. the authors appear concerned about the methods and results of our, at that time, unpublished sepsis trial evaluating hydroxyethyl starch (HES) and insulin therapy. Unfortunately, the authors' concerns are based on false assumptions about the design, conduct and modes of action of the compounds under investigation. For instance, in our study the HES solution was not used for maintenance of daily fluid requirements, so that the assumption of the authors that this colloid was used "exclusively" is wrong. Moreover, the manufacturer of Hemohes, the HES product we used, gives no cut-off value for creatinine, thus the assumption that this cut-off value was "doubled" in our study is also incorrect. Other claims by the authors such as that lactated solutions cause elevated lactate levels, iatrogenic hyperglycemia and increase O(2) consumption are unfounded. There is no randomized controlled trial supporting such a claim - this claim is neither consistent with our study data nor with any credible published sepsis guidelines or with routine practice worldwide. We fully support open scientific debate. Our study methods and results have now been published after a strict peer-reviewing process and this data is now open to critical and constructive reviewing. However, in our opinion this premature action based on wrong assumptions and containing comments by representatives of pharmaceutical companies does not contribute to a serious, unbiased scientific discourse.

Published
2008
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47. Study on the utility of a statewide counselling programme for improving mortality outcomes of patients with Staphylococcus aureus bacteraemia in Thuringia (SUPPORT): a study protocol of a cluster-randomised crossover trial.

Author

Weis, S., Hagel, S., Schmitz, R. P. H., Scherag, A., Brunkhorst, F. M., Forstner, C., Löffler, B., and Pletz, M. W.

Abstract

Introduction: Staphylococcus aureus bacteraemia (SAB) is a frequent infection with high mortality rates. It requires specific diagnostic and therapeutic management such as prolonged intravenous administration of antibiotics and aggressive search for and control of infectious sources. Underestimation of disease severity frequently results in delayed or inappropriate management of patients with SAB leading to increased mortality rates. According to observational studies, patient counselling by infectious disease consultants (IDC) improves survival and reduces the length of hospital stay as well as complication rates. In many countries, IDC are available only in some tertiary hospitals. In this trial, we aim to demonstrate that the outcome of patients with SAB in small and medium size hospitals that do not employ IDC can be improved by unsolicited ID phone counselling. The SUPPORT trial will be the first cluster-randomised controlled multicentre trial addressing this question. Methods and analysis: SUPPORT is a singleblinded, multicentre interventional, cluster-randomised, controlled crossover trial with a minimum of 15 centres that will include 250 patients with SAB who will receive unsolicited IDC counselling and 250 who will receive standard of care. Reporting of SAB will be conducted by an electronic real-time blood culture registry established for the German Federal state of Thuringia (ALERTSNet) or directly by participating centres in order to minimise time delay before counselling. Mortality, disease course and complications will be monitored for 90 days with 30-day all-cause mortality rates as the primary outcome. Generalised linear mixed modelling will be used to detect the difference between the intervention sequences. We expect improved outcome of patients with SAB after IDC. Ethics and dissemination: We obtained ethics approval from the Ethics committee of the Jena University Hospital and from the Ethics committee of the State Chamber of Physicians of Thuringia. Results will be published in a peer-reviewed journal and additionally disseminated through public media. [ABSTRACT FROM AUTHOR]

Published
2017
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