1. Lovastatin induces apoptosis through the mitochondrial pathway in an undifferentiated SH-SY5Y neuroblastoma cell line
- Author
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Paola Maura Tricarico, L. Vecchi Brumatti, Sergio Crovella, Annalisa Marcuzzi, Elisa Piscianz, Giulio Kleiner, Marcuzzi, Annalisa, Tricarico, PAOLA MAURA, Piscianz, Elisa, Kleiner, G, Brumatti, Lv, and Crovella, Sergio
- Subjects
Cancer Research ,Programmed cell death ,caspase ,Immunology ,Gene Expression ,Mevalonic Aciduria ,Mitochondrion ,NO ,Cellular and Molecular Neuroscience ,Cell Line, Tumor ,Correspondence ,Gene expression ,polycyclic compounds ,medicine ,Humans ,Lovastatin ,neoplasms ,Caspase ,Neurons ,Mevalonic aciduria ,apoptosis ,cell death ,biology ,organic chemicals ,nutritional and metabolic diseases ,Cell Biology ,apoptosi ,Mitochondria ,Cell biology ,Cell culture ,Apoptosis ,biology.protein ,lipids (amino acids, peptides, and proteins) ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,Signal transduction ,Signal Transduction ,medicine.drug - Abstract
Apoptosis in SH-SY5Y Lova-treated cells follows the mitochondrial pathway; that is, it is caspase-9 and caspase-3 dependent; however, we also demonstrated that caspase-1 plays a role in this still unclear mechanism. As statins induce the translocation of cytosolic Bax to the mitochondria and allow to permeabilize the mitochondrial outer membrane during apoptosis, further studies will be carried out on the expression of proapoptotic genes, such as Bax or Bcl2. These findings, even if obtained in an SH-SY5Y undifferentiated cell line, surely represent a first step towards the understanding of the neuronal damage caused by inflammation processes in MA.