23 results on '"Bruijninckx, C.M.A."'
Search Results
2. Haemodialysis Access-induced Distal Ischaemia (HAIDI) is Caused by Loco-regional Hypotension but not by Steal
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Scheltinga, M.R. and Bruijninckx, C.M.A.
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- 2012
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3. Validation of the Chronic Venous Insufficiency Quality of Life Questionnaire in Dutch Patients Treated for Varicose Veins
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Biemans, A.A.M., van der Velden, S.K., Bruijninckx, C.M.A., Buth, J., and Nijsten, T.
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- 2011
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4. Long-term Results of Primary Stent Placement to Treat Infrarenal Aortic Stenosis
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Simons, P.C.G., Nawijn, A.A., Bruijninckx, C.M.A., Knippenberg, B., de Vries, E.H., and van Overhagen, H.
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- 2006
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5. Limitations of Dutch Growth Research Foundation Commercial Software Weight Velocity for Age Standard Deviation Score
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Gemert, M.J.C. (Martin) van, Viaming, M., Koseoglu, B., Bruijninckx, C.M.A., Leeuwen, T.G. (Ton) van, Neumann, MHAM, Sauer, P.J.J., Gemert, M.J.C. (Martin) van, Viaming, M., Koseoglu, B., Bruijninckx, C.M.A., Leeuwen, T.G. (Ton) van, Neumann, MHAM, and Sauer, P.J.J.
- Abstract
Objective: Rare disease Background: The commercial software for hospitals, Weight Velocity for Age Standard Deviation Score (SDSWVA), claims to document the growth and development of children, although published details are unavailable. The statisticsderived parameter SDSWVA includes the weight velocity at age t, WV(t) (weight gained between t and (t–1.23) years, divided by 1.23), and 3 standard weight velocity curves at average age AA, defined as AA=t–1.23/2 years. SDSWVA denotes the number of standard deviations that WV(t) deviates from the 0 SD weight velocity at AA. WV(t) yielded erroneous outcomes when applied to weights of a seriously underweight boy with an allergy to cows’ milk who showed strong weight growth after being fed on food free of cows’ milk. The SDSWVA software tacitly suggests that it is more accurate than WV(t). Case Report: The case of this boy was previously described in this Journal. Using SDSWVA(t,AA) software, his weight growth was analyzed by his third pediatrician, beginning at age 1.5 years. The diagnosis of the mother with Pediatric Condition Falsification was confirmed, adding 6 months to foster care, which totalled 8.5 months. Testing of the SDSWVA software on the boy’s weight curve yielded results that were complex, nontransparent, and as erron
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- 2020
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6. Weight velocity equations with 14–448 days time separated weights should not be used for infants under 3 years of age
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Gemert, M.J.C. (Martin) van, Bruijninckx, C.M.A., Neumann, H.A.M. (H.A. Martino), Sauer, P.J.J. (Pieter J.J.), Bruin, D.M. (Martijn) de, van Leeuwen, T.G. (Ton G.), Gemert, M.J.C. (Martin) van, Bruijninckx, C.M.A., Neumann, H.A.M. (H.A. Martino), Sauer, P.J.J. (Pieter J.J.), Bruin, D.M. (Martijn) de, and van Leeuwen, T.G. (Ton G.)
- Abstract
Abnormal growth of infants may indicate disease of the children, thus methods to identify growth disorders are wanted in medicine. We previously showed that two-time-points weight growth velocities at age t, calculated by a commercial software product as [Weight(t)− Weight(t − X)]/X, with X = 448 days, were erroneous due to the long separation of 448 days. We were convinced that shorter X-values would solve this accuracy problem. However, our hypothesis is that: “shorter time separations than 448 days cause a decreased accuracy of numerical weight velocity equations in realistic infant weights until an age of about three years”. Supporting evidence comes from analyzing how shorter X-values will affect the accuracy of two-time-points weight velocity calculations. We systematically varied X between 1 and 448 days of various P50/0SD-related standard weight curves: (a)P50/0SD with the weights separated by 1 day and X = 1,28,224,448 days; (b)P50/0SD with the weights at variable ages and X = 14–448 days; and (c)case (b)and incorporating weight fluctuations typically occurring in infants. Cases (b)and (c)include details observed in a clinical case. Our results show that the combination of weight fluctuations and varying time intervals between consecutive weights make weight velocity predictions worse for shorter X values in children younger than three years. Because these two causes of failure occur naturally in infants whose weight is regularly measured, other weight velocity equations face the same causes for inaccuracy. In conclusion, our hypothesis suggests that any software that predicts weight velocities should be abandoned in infants < 3 years. Practically, it should require that when (commercial)software weight velocity prediction suggests a medical problem, careful clinical checking should be mandatory, e.g. by linking predicted and exact weight velocities at age t (the latter from the mathematical first derivative at age t of standard weight curves).
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- 2019
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7. Limitations of Weight Velocity Analysis by Commercial Computer Program Growth Analyser Viewer Edition
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Gemert, M.J.C. (Martin) van, Bruijninckx, C.M.A. (Cornelis M. A.), van Leeuwen, T.G. (Ton G.), Neumann, H.A.M. (H. A. Martino), Sauer, P.J.J. (Pieter), Gemert, M.J.C. (Martin) van, Bruijninckx, C.M.A. (Cornelis M. A.), van Leeuwen, T.G. (Ton G.), Neumann, H.A.M. (H. A. Martino), and Sauer, P.J.J. (Pieter)
- Abstract
Commercial software package “Growth Analyser Viewer Edition” (“GAVE”) aims to document, monitor and analyze growth and development in children and adolescents. Although its clinical and scientific use is widespread, there are no published studies that describe the method and its validation. We were informed that GAVE calculates the weight velocity (kg/year) at age t from the weight difference between t and 448 days earlier or at birth, divided by the time difference. We recently discussed a case of false child abuse diagnosis (Pediatric Condition Falsification), resulting in the separation of the child from its parents, in which GAVE played a negative contributing role. To prevent such inappropriate diagnoses, we analyzed GAVE from a schematic representation of the measured clinical weight curve, with precisely defined weight velocities. In conclusion, the 448 days included for weight velocity predictions by GAVE caused the erroneous outcomes. Until the necessary changes to the software are implemented and validated, we advise against the use of GAVE in infants younger than 1.5 years, if multiple weight changes occur within 448 days, and following a long-lasting weight velocity change. Our analysis suggests to discard all medical software packages that lack public description and proof of validation.
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- 2018
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8. Pediatric condition falsification misdiagnosed by misjudged weight growth from the curve of measured weights
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Gemert, M.J.C. (Martin) van, Vlaming, M. (Marianne), Osinga, E. (Eric), Bruijninckx, C.M.A. (Cornelis M. A.), Neumann, H.A.M. (H. A. Martino), Sauer, P.J.J. (Pieter), Gemert, M.J.C. (Martin) van, Vlaming, M. (Marianne), Osinga, E. (Eric), Bruijninckx, C.M.A. (Cornelis M. A.), Neumann, H.A.M. (H. A. Martino), and Sauer, P.J.J. (Pieter)
- Abstract
Objective: Rare disease Background: Pediatric condition falsification (PCF) is a rare form of child abuse in which a caregiver fabricates or induces illness in the child. The diagnosis is difficult and controversial and can easily include false positives. Case Report: A boy, 3.18 kg birthweight (P25 curve), lost weight between age 56 to120 days. Cow milk allergy was suspected, feeding was changed to elementary formula, and he started catch-up weight growth while remaining significantly underweight. His pediatrician continuously interpreted his low weight as insufficient growth, despite prescribing 3 times the normal caloric intake, concluded that the mother purposely malnourished her son, diagnosed PCF, and the boy was separated from his family (days 502–755 of age). PCF was confirmed by 2 other pediatricians and 3 child protection physicians and was supported by 4 child protection agencies and 6 judges. However, proper analysis of the weight growth (kg/year) from the weight curve showed a normal weight gain. Beyond 120 days of age, weight gain at home was significantly above normal (during 347–489 days: 6.2 versus 3 kg/year of the P50). He reached P25 again at around 516 days. Conclusions: The question “How could so many physicians misjudge weight gain?” has scientific and sociologic aspects. Scientifically, low weight was wrongly interpreted as insufficient weight growth, requiring that physicians learn how to assess weight gain from weight curves. Sociologically, physicians seem to follow a diagnosis made by a colleague without proper evaluation. Arguments provided by the parents against this diagnosis seemed to be neglected. Confirmation bias occurs when any information against PCF is disregarded.
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- 2018
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9. Long-term survival and secondary procedures after open or endovascular repair of abdominal aortic aneurysms
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van Schaik, Theodorus G., primary, Yeung, Kak K., additional, Verhagen, Hence J., additional, de Bruin, Jorg L., additional, van Sambeek, Marc R.H.M., additional, Balm, Ron, additional, Zeebregts, Clark J., additional, van Herwaarden, Joost A., additional, Blankensteijn, Jan D., additional, Grobbee, D.E., additional, Blankensteijn, J.D., additional, Bak, A.A.A., additional, Buth, J., additional, Pattynama, P.M., additional, Verhoeven, E.L.G., additional, van Voorthuisen, A.E., additional, Balm, R., additional, Cuypers, P.W.M., additional, Prinssen, M., additional, van Sambeek, M.R.H.M., additional, Baas, A.F., additional, Hunink, M.G., additional, van Engelshoven, J.M., additional, Jacobs, M.J.H.M., additional, de Mol, B.A.J.M., additional, van Bockel, J.H., additional, Reekers, J., additional, Tielbeek, X., additional, Wisselink, W., additional, Boekema, N., additional, Heuveling, L.M., additional, Sikking, I., additional, de Bruin, J.L., additional, Tielbeek, A.V., additional, Reekers, J.A., additional, Pattynama, P., additional, Prins, T., additional, van der Ham, A.C., additional, van der Velden, J.J.I.M., additional, van Sterkenburg, S.M.M., additional, ten Haken, G.B., additional, Bruijninckx, C.M.A., additional, van Overhagen, H., additional, Tutein Nolthenius, R.P., additional, Hendriksz, T.R., additional, Teijink, J.A.W., additional, Odink, H.F., additional, de Smet, A.A.E.A., additional, Vroegindeweij, D., additional, van Loenhout, R.M.M., additional, Rutten, M.J., additional, Hamming, J.F., additional, Lampmann, L.E.H., additional, Bender, M.H.M., additional, Pasmans, H., additional, Vahl, A.C., additional, de Vries, C., additional, Mackaay, A.J.C., additional, van Dortmont, L.M.C., additional, van der Vliet, A.J., additional, Schultze Kool, L.J., additional, Boomsma, J.H.B., additional, van Dop, H.R., additional, de Mol van Otterloo, J.C.A., additional, de Rooij, T.P.W., additional, Smits, T.M., additional, Yilmaz, E.N., additional, van den Berg, F.G., additional, Visser, M.J.T., additional, van der Linden, E., additional, Schurink, G.W.H., additional, de Haan, M., additional, Smeets, H.J., additional, Stabel, P., additional, van Elst, F., additional, Poniewierski, J., additional, and Vermassen, F.E.G., additional
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- 2017
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10. Predicting reinterventions after open and endovascular aneurysm repair using the St George's Vascular Institute score
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de Bruin, Jorg Lucas, primary, Karthikesalingam, Alan, additional, Holt, Peter J., additional, Prinssen, Monique, additional, Thompson, Matt M., additional, Blankensteijn, Jan D., additional, Grobbee, D.E., additional, Blankensteijn, J.D., additional, Bak, A.A.A., additional, Buth, J., additional, Pattynama, P.M., additional, Verhoeven, E.L.G., additional, van Voorthuisen, A.E., additional, Balm, R., additional, Cuypers, P.W.M., additional, Prinssen, M., additional, van Sambeek, M.R.H.M., additional, Baas, A.F., additional, Hunink, M.G., additional, van Engelshoven, J.M., additional, Jacobs, M.J.H.M., additional, de Mol, B.A.J.M., additional, van Bockel, J.H., additional, Reekers, J., additional, Tielbeek, X., additional, Wisselink, W., additional, Boekema, N., additional, Heuveling, L.M., additional, Sikking, I., additional, de Bruin, J.L., additional, Tielbeek, A.V., additional, Reekers, J.A., additional, Pattynama, P., additional, Prins, T., additional, van der Ham, A.C., additional, van der Velden, J.J.I.M., additional, van Sterkenburg, S.M.M., additional, ten Haken, G.B., additional, Bruijninckx, C.M.A., additional, van Overhagen, H., additional, Tutein Nolthenius, R.P., additional, Hendriksz, T.R., additional, Teijink, J.A.W., additional, Odink, H.F., additional, de Smet, A.A.E.A., additional, Vroegindeweij, D., additional, van Loenhout, R.M.M., additional, Rutten, M.J., additional, Hamming, J.F., additional, Lampmann, L.E.H., additional, Bender, M.H.M., additional, Pasmans, H., additional, Vahl, A.C., additional, de Vries, C., additional, Mackaay, A.J.C., additional, van Dortmont, L.M.C., additional, van der Vliet, A.J., additional, Schultze Kool, L.J., additional, Boomsma, J.H.B., additional, van, H.R., additional, de Mol van Otterloo, J.C.A., additional, de Rooij, T.P.W., additional, Smits, T.M., additional, Yilmaz, E.N., additional, van den Berg, F.G., additional, Visser, M.J.T., additional, van der Linden, E., additional, Schurink, G.W.H., additional, de Haan, M., additional, Smeets, H.J., additional, Stabel, P., additional, van Elst, F., additional, Poniewierski, J., additional, and Vermassen, F.E.G., additional
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- 2016
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11. Periprocedural antithrombotics in arterial procedures: The road to consensus ...
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Moll, Frans L, Bruijninckx, C.M.A., Vos, J.A., Wiersema, A.M., Moll, Frans L, Bruijninckx, C.M.A., Vos, J.A., and Wiersema, A.M.
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- 2014
12. Endovenous laser ablation (EVLA) : a review of mechanisms, modeling outcomes, and issues for debate
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Malskat, W.S.J., Poluektova, A.A., Geld, van der, C.W.M., Neumann, H.A.M., Weiss, R.A., Bruijninckx, C.M.A., Gemert, van, M.J.C., Malskat, W.S.J., Poluektova, A.A., Geld, van der, C.W.M., Neumann, H.A.M., Weiss, R.A., Bruijninckx, C.M.A., and Gemert, van, M.J.C.
- Abstract
Endovenous laser ablation (EVLA) is a commonly used and very effective minimally invasive therapy to manage leg varicosities. Yet, and despite a clinical history of 16 years, no international consensus on a best treatment protocol has been reached so far. Evidence presented in this paper supports the opinion that insufficient knowledge of the underlying physics amongst frequent users could explain this shortcoming. In this review, we will examine the possible modes of action of EVLA, hoping that better understanding of EVLA-related physics stimulates critical appraisal of claims made concerning the efficacy of EVLA devices, and may advance identifying a best possible treatment protocol. Finally, physical arguments are presented to debate on long-standing, but often unfounded, clinical opinions and habits. This includes issues such as (1) the importance of laser power versus the lack of clinical relevance of laser energy (Joule) as used in Joule per centimeter vein length, i.e., in linear endovenous energy density (LEED), and Joule per square centimeter vein wall area, (2) the predicted effectiveness of a higher power and faster pullback velocity, (3) the irrelevance of whether laser light is absorbed by hemoglobin or water, and (4) the effectiveness of reducing the vein diameter during EVLA therapy.
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- 2014
13. Periprocedural antithrombotics in arterial procedures: The road to consensus ...
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Circulatory Health, Zorgeenheid Vaatchirurgie Medisch, Moll, FL, Bruijninckx, C.M.A., Vos, J.A., Wiersema, A.M., Circulatory Health, Zorgeenheid Vaatchirurgie Medisch, Moll, FL, Bruijninckx, C.M.A., Vos, J.A., and Wiersema, A.M.
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- 2014
14. Endovenous laser ablation (EVLA): a review of mechanisms, modeling outcomes, and issues for debate
- Author
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Malskat, W.S.J. (Wendy), Poluektova, A.A. (Anna), Geld, C.W.M. (Cees) van der, Neumann, H.A.M. (Martino), Weiss, R.A. (Robert), Bruijninckx, C.M.A., Gemert, M.J.C. (Martin) van, Malskat, W.S.J. (Wendy), Poluektova, A.A. (Anna), Geld, C.W.M. (Cees) van der, Neumann, H.A.M. (Martino), Weiss, R.A. (Robert), Bruijninckx, C.M.A., and Gemert, M.J.C. (Martin) van
- Abstract
Endovenous laser ablation (EVLA) is a commonly used and very effective minimally invasive therapy to manage leg varicosities. Yet, and despite a clinical history of 16 years, no international consensus on a best treatment protocol has been reached so far. Evidence presented in this paper supports the opinion that insufficient knowledge of the underlying physics amongst frequent users could explain this shortcoming. In this review, we will examine the possible modes of action of EVLA, hoping that better understanding of EVLA-related physics stimulates critical appraisal of claims made concerning the efficacy of EVLA devices, and may advance identifying a best possible treatment protocol. Finally, physical arguments are presented to debate on long-standing, but often unfounded, clinical opinions and habits. This includes issues such as (1) the importance of laser power versus the lack of clinical relevance of laser energy (Joule) as used in Joule per centimeter vein length, i.e., in linear endovenous energy density (LEED), and Joule per square centimeter vein wall area, (2) the predicted effectiveness of a higher power and faster pullback velocity, (3) the irrelevance of whether laser light is absorbed by hemoglobin or water, and (4) the effectiveness of reducing the vein diameter during EVLA therapy.
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- 2013
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15. Carotid artery stenting compared with endarterectomy in patients with symptomatic carotid stenosis (International Carotid Stenting Study): an interim analysis of a randomised controlled trial.
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Giroux M.-F., Prakash K.G., Serracino-Inglott F., Subramanian G., Symth J.V., Walker M.G., Clarke M., Davis M., Dixit S.A., Dorman P., Dyker A., Ford G., Golkar A., Jackson R., Jayakrishnan V., Lambert D., Lees T., Louw S., Mendelow A.D., Rodgers H., Rose J., Stansby G., Wyatt M., Baker T., Baldwin N., Jones L., Mitchell D., Munro E., Thornton M., Baker D., Davis N., Hamilton G., Platts A., Tibballs J., Beard J., Cleveland T., Dodd D., Gaines P., Lonsdale R., Nair R., Nassef A., Nawaz S., Venables G., Belli A., Clifton A., Cloud G., Halliday A., Markus H., McFarland R., Morgan R., Pereira A., Thompson A., Chataway J., Cheshire N., Gibbs R., Hammady M., Jenkins M., Malik I., Wolfe J., Adiseshiah M., Bishop C., Brew S., Brookes J., Jager R., Kitchen N., Ashleigh R., Butterfield S., Gamble G.E., Nasim A., O'Neill P., Wong J., Edwards R.D., Lees K.R., MacKay A.J., Moss J., Rogers P., Ederle J., Dobson J., Featherstone R.L., Bonati L.H., van der Worp H.B., de Borst G.J., Hauw Lo T., Dorman P.J., Macdonald S., Lyrer P.A., McCollum C., Nederkoorn P.J., Brown M.M., Algra A., Bamford J., Bland M., Hacke W., Mas J.L., McGuire A.J., Sidhu P., Bradbury A., Collins R., Molyneux A., Naylor R., Warlow C., Ferro M., Thomas D., Featherstone R.F., Tindall H., McCabe D., Wallis A., Coward L., Brooks M., Chambers B., Chan A., Chu P., Clark D., Dewey H., Donnan G., Fell G., Hoare M., Molan M., Roberts A., Roberts N., Beiles B., Bladin C., Clifford C., Grigg M., New G., Bell R., Bower S., Chong W., Holt M., Saunder A., Than P.G., Gett S., Leggett D., McGahan T., Quinn J., Ray M., Wong A., Woodruff P., Foreman R., Schultz D., Scroop R., Stanley B., Allard B., Atkinson N., Cambell W., Davies S., Field P., Milne P., Mitchell P., Tress B., Yan B., Beasley A., Dunbabin D., Stary D., Walker S., Cras P., d'Archambeau O., Hendriks J.M.H., Van Schil P., Bosiers M., Deloose K., van Buggenhout E., De Letter J., Devos V., Ghekiere J., Vanhooren G., Astarci P., Hammer F., Lacroix V., Verhelst R., DeJaegher L., Peeters A., Verbist J., Blair J.-F., Caron J.L., Daneault N., Guilbert F., Lanthier S., Lebrun L.-H., Oliva V., Raymond J., Roy D., Soulez G., Weill A., Hill M., Hu W., Hudion M., Morrish W., Sutherland G., Alback A., Harno H., Ijas P., Kaste M., Lepantalo M., Mustanoja S., Paananen T., Porras M., Putaala J., Railo M., Sairanen T., Soinne L., Vehmas A., Vikatmaa P., Goertler M., Halloul Z., Skalej M., Brennan P., Kelly C., Leahy A., Moroney J., Thornton J., Koelemay M.J.W., Reekers J.A.A., Roos Y.B.W.E.M., Hendriks J.M., Koudstaal P.J., Pattynama P.M.T., van der Lugt A., van Dijk L.C., van Sambeek M.R.H.M., van Urk H., Verhagen H.J.M., Bruijninckx C.M.A., de Bruijn S.F., Keunen R., Knippenberg B., Mosch A., Treurniet F., van Dijk L., van Overhagen H., Wever J., de Beer F.C., van den Berg J.S.P., van Hasselt B.A.A.M., Zeilstra D.J., Boiten J., de Mol van Otterloo J.C.A., de Vries A.C., Lycklama a Nijeholt G.J., van der Kallen B.F.W., Blankensteijn J.D., De Leeuw F.E., Schultze Kool L.J., van der Vliet J.A., de Kort G.A.P., Kapelle L.J., Lo T.H., Mali W.P.T.M., Moll F., Verhagen H., Barber P.A., Bourchier R., Hill A., Holden A., Stewart J., Bakke S.J., Krohg-Sorensen K., Skjelland M., Tennoe B., Bialek P., Biejat Z., Czepiel W., Czlonkowska A., Dowzenko A., Jedrzejewska J., Kobayashi A., Lelek M., Polanski J., Kirbis J., Milosevic Z., Zvan B., Blasco J., Chamorro A., Macho J., Obach V., Riambau V., San Roman L., Branera J., Canovas D., Estela J., Gimenez Gaibar A., Perendreu J., Bjorses K., Gottsater A., Ivancev K., Maetzsch T., Sonesson B., Berg B., Delle M., Formgren J., Gillgren P., Kall T.-B., Konrad P., Nyman N., Takolander R., Andersson T., Malmstedt J., Soderman M., Wahlgren C., Wahlgren N., Binaghi S., Hirt L., Michel P., Ruchat P., Engelter S.T., Fluri F., Guerke L., Jacob A.L., Kirsch E., Radue E.-W., Stierli P., Wasner M., Wetzel S., Bonvin C., Kalangos A., Lovblad K., Murith N., Ruefenacht D., Sztajzel R., Higgins N., Kirkpatrick P.J., Martin P., Adam D., Bell J., Bradbury A.W., Crowe P., Gannon M., Henderson M.J., Sandler D., Shinton R.A., Scriven J.M., Wilmink T., D'Souza S., Egun A., Guta R., Punekar S., Seriki D.M., Thomson G., Brennan J.A., Enevoldson T.P., Gilling-Smith G., Gould D.A., Harris P.L., McWilliams R.G., Nasser H.-C., White R., Giroux M.-F., Prakash K.G., Serracino-Inglott F., Subramanian G., Symth J.V., Walker M.G., Clarke M., Davis M., Dixit S.A., Dorman P., Dyker A., Ford G., Golkar A., Jackson R., Jayakrishnan V., Lambert D., Lees T., Louw S., Mendelow A.D., Rodgers H., Rose J., Stansby G., Wyatt M., Baker T., Baldwin N., Jones L., Mitchell D., Munro E., Thornton M., Baker D., Davis N., Hamilton G., Platts A., Tibballs J., Beard J., Cleveland T., Dodd D., Gaines P., Lonsdale R., Nair R., Nassef A., Nawaz S., Venables G., Belli A., Clifton A., Cloud G., Halliday A., Markus H., McFarland R., Morgan R., Pereira A., Thompson A., Chataway J., Cheshire N., Gibbs R., Hammady M., Jenkins M., Malik I., Wolfe J., Adiseshiah M., Bishop C., Brew S., Brookes J., Jager R., Kitchen N., Ashleigh R., Butterfield S., Gamble G.E., Nasim A., O'Neill P., Wong J., Edwards R.D., Lees K.R., MacKay A.J., Moss J., Rogers P., Ederle J., Dobson J., Featherstone R.L., Bonati L.H., van der Worp H.B., de Borst G.J., Hauw Lo T., Dorman P.J., Macdonald S., Lyrer P.A., McCollum C., Nederkoorn P.J., Brown M.M., Algra A., Bamford J., Bland M., Hacke W., Mas J.L., McGuire A.J., Sidhu P., Bradbury A., Collins R., Molyneux A., Naylor R., Warlow C., Ferro M., Thomas D., Featherstone R.F., Tindall H., McCabe D., Wallis A., Coward L., Brooks M., Chambers B., Chan A., Chu P., Clark D., Dewey H., Donnan G., Fell G., Hoare M., Molan M., Roberts A., Roberts N., Beiles B., Bladin C., Clifford C., Grigg M., New G., Bell R., Bower S., Chong W., Holt M., Saunder A., Than P.G., Gett S., Leggett D., McGahan T., Quinn J., Ray M., Wong A., Woodruff P., Foreman R., Schultz D., Scroop R., Stanley B., Allard B., Atkinson N., Cambell W., Davies S., Field P., Milne P., Mitchell P., Tress B., Yan B., Beasley A., Dunbabin D., Stary D., Walker S., Cras P., d'Archambeau O., Hendriks J.M.H., Van Schil P., Bosiers M., Deloose K., van Buggenhout E., De Letter J., Devos V., Ghekiere J., Vanhooren G., Astarci P., Hammer F., Lacroix V., Verhelst R., DeJaegher L., Peeters A., Verbist J., Blair J.-F., Caron J.L., Daneault N., Guilbert F., Lanthier S., Lebrun L.-H., Oliva V., Raymond J., Roy D., Soulez G., Weill A., Hill M., Hu W., Hudion M., Morrish W., Sutherland G., Alback A., Harno H., Ijas P., Kaste M., Lepantalo M., Mustanoja S., Paananen T., Porras M., Putaala J., Railo M., Sairanen T., Soinne L., Vehmas A., Vikatmaa P., Goertler M., Halloul Z., Skalej M., Brennan P., Kelly C., Leahy A., Moroney J., Thornton J., Koelemay M.J.W., Reekers J.A.A., Roos Y.B.W.E.M., Hendriks J.M., Koudstaal P.J., Pattynama P.M.T., van der Lugt A., van Dijk L.C., van Sambeek M.R.H.M., van Urk H., Verhagen H.J.M., Bruijninckx C.M.A., de Bruijn S.F., Keunen R., Knippenberg B., Mosch A., Treurniet F., van Dijk L., van Overhagen H., Wever J., de Beer F.C., van den Berg J.S.P., van Hasselt B.A.A.M., Zeilstra D.J., Boiten J., de Mol van Otterloo J.C.A., de Vries A.C., Lycklama a Nijeholt G.J., van der Kallen B.F.W., Blankensteijn J.D., De Leeuw F.E., Schultze Kool L.J., van der Vliet J.A., de Kort G.A.P., Kapelle L.J., Lo T.H., Mali W.P.T.M., Moll F., Verhagen H., Barber P.A., Bourchier R., Hill A., Holden A., Stewart J., Bakke S.J., Krohg-Sorensen K., Skjelland M., Tennoe B., Bialek P., Biejat Z., Czepiel W., Czlonkowska A., Dowzenko A., Jedrzejewska J., Kobayashi A., Lelek M., Polanski J., Kirbis J., Milosevic Z., Zvan B., Blasco J., Chamorro A., Macho J., Obach V., Riambau V., San Roman L., Branera J., Canovas D., Estela J., Gimenez Gaibar A., Perendreu J., Bjorses K., Gottsater A., Ivancev K., Maetzsch T., Sonesson B., Berg B., Delle M., Formgren J., Gillgren P., Kall T.-B., Konrad P., Nyman N., Takolander R., Andersson T., Malmstedt J., Soderman M., Wahlgren C., Wahlgren N., Binaghi S., Hirt L., Michel P., Ruchat P., Engelter S.T., Fluri F., Guerke L., Jacob A.L., Kirsch E., Radue E.-W., Stierli P., Wasner M., Wetzel S., Bonvin C., Kalangos A., Lovblad K., Murith N., Ruefenacht D., Sztajzel R., Higgins N., Kirkpatrick P.J., Martin P., Adam D., Bell J., Bradbury A.W., Crowe P., Gannon M., Henderson M.J., Sandler D., Shinton R.A., Scriven J.M., Wilmink T., D'Souza S., Egun A., Guta R., Punekar S., Seriki D.M., Thomson G., Brennan J.A., Enevoldson T.P., Gilling-Smith G., Gould D.A., Harris P.L., McWilliams R.G., Nasser H.-C., and White R.
- Abstract
Background: Stents are an alternative treatment to carotid endarterectomy for symptomatic carotid stenosis, but previous trials have not established equivalent safety and efficacy. We compared the safety of carotid artery stenting with that of carotid endarterectomy. Method(s): The International Carotid Stenting Study (ICSS) is a multicentre, international, randomised controlled trial with blinded adjudication of outcomes. Patients with recently symptomatic carotid artery stenosis were randomly assigned in a 1:1 ratio to receive carotid artery stenting or carotid endarterectomy. Randomisation was by telephone call or fax to a central computerised service and was stratified by centre with minimisation for sex, age, contralateral occlusion, and side of the randomised artery. Patients and investigators were not masked to treatment assignment. Patients were followed up by independent clinicians not directly involved in delivering the randomised treatment. The primary outcome measure of the trial is the 3-year rate of fatal or disabling stroke in any territory, which has not been analysed yet. The main outcome measure for the interim safety analysis was the 120-day rate of stroke, death, or procedural myocardial infarction. Analysis was by intention to treat (ITT). This study is registered, number ISRCTN25337470. Finding(s): The trial enrolled 1713 patients (stenting group, n=855; endarterectomy group, n=858). Two patients in the stenting group and one in the endarterectomy group withdrew immediately after randomisation, and were not included in the ITT analysis. Between randomisation and 120 days, there were 34 (Kaplan-Meier estimate 4.0%) events of disabling stroke or death in the stenting group compared with 27 (3.2%) events in the endarterectomy group (hazard ratio [HR] 1.28, 95% CI 0.77-2.11). The incidence of stroke, death, or procedural myocardial infarction was 8.5% in the stenting group compared with 5.2% in the endarterectomy group (72 vs 44 events; HR 1.69, 1.
- Published
- 2010
16. Carotid artery stenting compared with endarterectomy in patients with symptomatic carotid stenosis (International Carotid Stenting Study): an interim analysis of a randomised controlled trial
- Author
-
Ederle, Jörg, Dobson, Joanna, Featherstone, Roland L., Bonati, Leo H., van der Worp, H. Bart, de Borst, Gert J., Hauw Lo, T., Gaines, Peter, Dorman, Paul J., Macdonald, Sumaira, Lyrer, Philippe A., Hendriks, Johanna M., McCollum, Charles, Nederkoorn, Paul J., Brown, Martin M., Algra, A., Bamford, J., Bland, M., Hacke, W., Mas, J.L., McGuire, A.J., Sidhu, P., Bradbury, A., Collins, R., Molyneux, A., Naylor, R., Warlow, C., Ferro, M., Thomas, D., Featherstone, R.F., Tindall, H., McCabe, D.J.H., Wallis, A., Coward, L., Brooks, M., Chambers, B., Chan, A., Chu, P., Clark, D., Dewey, H., Donnan, G., Fell, G., Hoare, M., Molan, M., Roberts, A., Roberts, N., Beiles, B., Bladin, C., Clifford, C., Grigg, M., New, G., Bell, R., Bower, S., Chong, W., Holt, M., Saunder, A., Than, P.G., Gett, S., Leggett, D., McGahan, T., Quinn, J., Ray, M., Wong, A., Woodruff, P., Foreman, R., Schultz, D., Scroop, R., Stanley, B., Allard, B., Atkinson, N., Cambell, W., Davies, S., Field, P., Milne, P., Mitchell, P., Tress, B., Yan, B., Beasley, A., Dunbabin, D., Stary, D., Walker, S., Cras, P., d'Archambeau, O., Hendriks, J.M.H., Van Schil, P., Bosiers, M., Deloose, K., van Buggenhout, E., De Letter, J., Devos, V., Ghekiere, J., Vanhooren, G., Astarci, P., Hammer, F., Lacroix, V., Peeters, A., Verhelst, R., DeJaegher, L., Verbist, J., Blair, J.-F., Caron, J.L., Daneault, N., Giroux, M.-F., Guilbert, F., Lanthier, S., Lebrun, L.-H., Oliva, V., Raymond, J., Roy, D., Soulez, G., Weill, A., Hill, M., Hu, W., Hudion, M., Morrish, W., Sutherland, G., Wong, J., Albäck, A., Harno, H., Ijäs, P., Kaste, M., Lepäntalo, M., Mustanoja, S., Paananen, T., Porras, M., Putaala, J., Railo, M., Sairanen, T., Soinne, L., Vehmas, A., Vikatmaa, P., Goertler, M., Halloul, Z., Skalej, M., Brennan, P., Kelly, C., Leahy, A., Moroney, J., Thornton, J., Koelemay, M.J.W., Reekers, J.A.A., Roos, Y.B.W.E.M., Hendriks, J.M., Koudstaal, P.J., Pattynama, P.M.T., van der Lugt, A., van Dijk, L.C., van Sambeek, M.R.H.M., van Urk, H., Verhagen, H.J.M., Bruijninckx, C.M.A., de Bruijn, S.F., Keunen, R., Knippenberg, B., Mosch, A., Treurniet, F., van Dijk, L., van Overhagen, H., Wever, J., de Beer, F.C., van den Berg, J.S.P., van Hasselt, B.A.A.M., Zeilstra, D.J., Boiten, J., de Mol van Otterloo, J.C.A., de Vries, A.C., Lycklama a Nijeholt, G.J., van der Kallen, B.F.W., Blankensteijn, J.D., De Leeuw, F.E., Schultze Kool, L.J., van der Vliet, J.A., de Kort, G.A.P., Kapelle, L.J., Lo, T.H., Mali, W.P.T.M., Moll, F., Verhagen, H., Barber, P.A., Bourchier, R., Hill, A., Holden, A., Stewart, J., Bakke, S.J., Krohg-Sørensen, K., Skjelland, M., Tennøe, B., Bialek, P., Biejat, Z., Czepiel, W., Czlonkowska, A., Dowzenko, A., Jedrzejewska, J., Kobayashi, A., Lelek, M., Polanski, J., Kirbis, J., Milosevic, Z., Zvan, B., Blasco, J., Chamorro, A., Macho, J., Obach, V., Riambau, V., San Roman, L., Branera, J., Canovas, D., Estela, Jordi, Gimenez Gaibar, A., Perendreu, J., Björses, K., Gottsater, A., Ivancev, K., Maetzsch, T., Sonesson, B., Berg, B., Delle, M., Formgren, J., Gillgren, P., Kall, T.-B., Konrad, P., Nyman, N., Takolander, R., Andersson, T., Malmstedt, J., Soderman, M., Wahlgren, C., Wahlgren, N., Binaghi, S., Hirt, L., Michel, P., Ruchat, P., Engelter, S.T., Fluri, F., Guerke, L., Jacob, A.L., Kirsch, E., Radue, E.-W., Stierli, P., Wasner, M., Wetzel, S., Bonvin, C., Kalangos, A., Lovblad, K., Murith, N., Ruefenacht, D., Sztajzel, R., Higgins, N., Kirkpatrick, P.J., Martin, P., Adam, D., Bell, J., Bradbury, A.W., Crowe, P., Gannon, M., Henderson, M.J., Sandler, D., Shinton, R.A., Scriven, J.M., Wilmink, T., D'Souza, S., Egun, A., Guta, R., Punekar, S., Seriki, D.M., Thomson, G., Brennan, J.A., Enevoldson, T.P., Gilling-Smith, G., Gould, D.A., Harris, P.L., McWilliams, R.G., Nasser, H.-C., White, R., Prakash, K.G., Serracino-Inglott, F., Subramanian, G., Symth, J.V., Walker, M.G., Clarke, M., Davis, M., Dixit, S.A., Dorman, P., Dyker, A., Ford, G., Golkar, A., Jackson, R., Jayakrishnan, V., Lambert, D., Lees, T., Louw, S., Mendelow, A.D., Rodgers, H., Rose, J., Stansby, G., Wyatt, M., Baker, T., Baldwin, N., Jones, L., Mitchell, D., Munro, E., Thornton, M., Baker, D., Davis, N., Hamilton, G., McCabe, D., Platts, A., Tibballs, J., Beard, J., Cleveland, T., Dodd, D., Gaines, P., Lonsdale, R., Nair, R., Nassef, A., Nawaz, S., Venables, G., Belli, A., Clifton, A., Cloud, G., Halliday, A., Markus, H., McFarland, R., Morgan, R., Pereira, A., Thompson, A., Chataway, J., Cheshire, N., Gibbs, R., Hammady, M., Jenkins, M., Malik, I., Wolfe, J., Adiseshiah, M., Bishop, C., Brew, S., Brookes, J., Jäger, R., Kitchen, N., Ashleigh, R., Butterfield, S., Gamble, G.E., Nasim, A., O'Neill, P., Edwards, R.D., Lees, K.R., MacKay, A.J., Moss, J., Rogers, P., Ederle, Jörg, Dobson, Joanna, Featherstone, Roland L., Bonati, Leo H., van der Worp, H. Bart, de Borst, Gert J., Hauw Lo, T., Gaines, Peter, Dorman, Paul J., Macdonald, Sumaira, Lyrer, Philippe A., Hendriks, Johanna M., McCollum, Charles, Nederkoorn, Paul J., Brown, Martin M., Algra, A., Bamford, J., Bland, M., Hacke, W., Mas, J.L., McGuire, A.J., Sidhu, P., Bradbury, A., Collins, R., Molyneux, A., Naylor, R., Warlow, C., Ferro, M., Thomas, D., Featherstone, R.F., Tindall, H., McCabe, D.J.H., Wallis, A., Coward, L., Brooks, M., Chambers, B., Chan, A., Chu, P., Clark, D., Dewey, H., Donnan, G., Fell, G., Hoare, M., Molan, M., Roberts, A., Roberts, N., Beiles, B., Bladin, C., Clifford, C., Grigg, M., New, G., Bell, R., Bower, S., Chong, W., Holt, M., Saunder, A., Than, P.G., Gett, S., Leggett, D., McGahan, T., Quinn, J., Ray, M., Wong, A., Woodruff, P., Foreman, R., Schultz, D., Scroop, R., Stanley, B., Allard, B., Atkinson, N., Cambell, W., Davies, S., Field, P., Milne, P., Mitchell, P., Tress, B., Yan, B., Beasley, A., Dunbabin, D., Stary, D., Walker, S., Cras, P., d'Archambeau, O., Hendriks, J.M.H., Van Schil, P., Bosiers, M., Deloose, K., van Buggenhout, E., De Letter, J., Devos, V., Ghekiere, J., Vanhooren, G., Astarci, P., Hammer, F., Lacroix, V., Peeters, A., Verhelst, R., DeJaegher, L., Verbist, J., Blair, J.-F., Caron, J.L., Daneault, N., Giroux, M.-F., Guilbert, F., Lanthier, S., Lebrun, L.-H., Oliva, V., Raymond, J., Roy, D., Soulez, G., Weill, A., Hill, M., Hu, W., Hudion, M., Morrish, W., Sutherland, G., Wong, J., Albäck, A., Harno, H., Ijäs, P., Kaste, M., Lepäntalo, M., Mustanoja, S., Paananen, T., Porras, M., Putaala, J., Railo, M., Sairanen, T., Soinne, L., Vehmas, A., Vikatmaa, P., Goertler, M., Halloul, Z., Skalej, M., Brennan, P., Kelly, C., Leahy, A., Moroney, J., Thornton, J., Koelemay, M.J.W., Reekers, J.A.A., Roos, Y.B.W.E.M., Hendriks, J.M., Koudstaal, P.J., Pattynama, P.M.T., van der Lugt, A., van Dijk, L.C., van Sambeek, M.R.H.M., van Urk, H., Verhagen, H.J.M., Bruijninckx, C.M.A., de Bruijn, S.F., Keunen, R., Knippenberg, B., Mosch, A., Treurniet, F., van Dijk, L., van Overhagen, H., Wever, J., de Beer, F.C., van den Berg, J.S.P., van Hasselt, B.A.A.M., Zeilstra, D.J., Boiten, J., de Mol van Otterloo, J.C.A., de Vries, A.C., Lycklama a Nijeholt, G.J., van der Kallen, B.F.W., Blankensteijn, J.D., De Leeuw, F.E., Schultze Kool, L.J., van der Vliet, J.A., de Kort, G.A.P., Kapelle, L.J., Lo, T.H., Mali, W.P.T.M., Moll, F., Verhagen, H., Barber, P.A., Bourchier, R., Hill, A., Holden, A., Stewart, J., Bakke, S.J., Krohg-Sørensen, K., Skjelland, M., Tennøe, B., Bialek, P., Biejat, Z., Czepiel, W., Czlonkowska, A., Dowzenko, A., Jedrzejewska, J., Kobayashi, A., Lelek, M., Polanski, J., Kirbis, J., Milosevic, Z., Zvan, B., Blasco, J., Chamorro, A., Macho, J., Obach, V., Riambau, V., San Roman, L., Branera, J., Canovas, D., Estela, Jordi, Gimenez Gaibar, A., Perendreu, J., Björses, K., Gottsater, A., Ivancev, K., Maetzsch, T., Sonesson, B., Berg, B., Delle, M., Formgren, J., Gillgren, P., Kall, T.-B., Konrad, P., Nyman, N., Takolander, R., Andersson, T., Malmstedt, J., Soderman, M., Wahlgren, C., Wahlgren, N., Binaghi, S., Hirt, L., Michel, P., Ruchat, P., Engelter, S.T., Fluri, F., Guerke, L., Jacob, A.L., Kirsch, E., Radue, E.-W., Stierli, P., Wasner, M., Wetzel, S., Bonvin, C., Kalangos, A., Lovblad, K., Murith, N., Ruefenacht, D., Sztajzel, R., Higgins, N., Kirkpatrick, P.J., Martin, P., Adam, D., Bell, J., Bradbury, A.W., Crowe, P., Gannon, M., Henderson, M.J., Sandler, D., Shinton, R.A., Scriven, J.M., Wilmink, T., D'Souza, S., Egun, A., Guta, R., Punekar, S., Seriki, D.M., Thomson, G., Brennan, J.A., Enevoldson, T.P., Gilling-Smith, G., Gould, D.A., Harris, P.L., McWilliams, R.G., Nasser, H.-C., White, R., Prakash, K.G., Serracino-Inglott, F., Subramanian, G., Symth, J.V., Walker, M.G., Clarke, M., Davis, M., Dixit, S.A., Dorman, P., Dyker, A., Ford, G., Golkar, A., Jackson, R., Jayakrishnan, V., Lambert, D., Lees, T., Louw, S., Mendelow, A.D., Rodgers, H., Rose, J., Stansby, G., Wyatt, M., Baker, T., Baldwin, N., Jones, L., Mitchell, D., Munro, E., Thornton, M., Baker, D., Davis, N., Hamilton, G., McCabe, D., Platts, A., Tibballs, J., Beard, J., Cleveland, T., Dodd, D., Gaines, P., Lonsdale, R., Nair, R., Nassef, A., Nawaz, S., Venables, G., Belli, A., Clifton, A., Cloud, G., Halliday, A., Markus, H., McFarland, R., Morgan, R., Pereira, A., Thompson, A., Chataway, J., Cheshire, N., Gibbs, R., Hammady, M., Jenkins, M., Malik, I., Wolfe, J., Adiseshiah, M., Bishop, C., Brew, S., Brookes, J., Jäger, R., Kitchen, N., Ashleigh, R., Butterfield, S., Gamble, G.E., Nasim, A., O'Neill, P., Edwards, R.D., Lees, K.R., MacKay, A.J., Moss, J., and Rogers, P.
- Abstract
Background: Stents are an alternative treatment to carotid endarterectomy for symptomatic carotid stenosis, but previous trials have not established equivalent safety and efficacy. We compared the safety of carotid artery stenting with that of carotid endarterectomy. Methods: The International Carotid Stenting Study (ICSS) is a multicentre, international, randomised controlled trial with blinded adjudication of outcomes. Patients with recently symptomatic carotid artery stenosis were randomly assigned in a 1:1 ratio to receive carotid artery stenting or carotid endarterectomy. Randomisation was by telephone call or fax to a central computerised service and was stratified by centre with minimisation for sex, age, contralateral occlusion, and side of the randomised artery. Patients and investigators were not masked to treatment assignment. Patients were followed up by independent clinicians not directly involved in delivering the randomised treatment. The primary outcome measure of the trial is the 3-year rate of fatal or disabling stroke in any territory, which has not been analysed yet. The main outcome measure for the interim safety analysis was the 120-day rate of stroke, death, or procedural myocardial infarction. Analysis was by intention to treat (ITT). This study is registered, number ISRCTN25337470. Findings: The trial enrolled 1713 patients (stenting group, n=855; endarterectomy group, n=858). Two patients in the stenting group and one in the endarterectomy group withdrew immediately after randomisation, and were not included in the ITT analysis. Between randomisation and 120 days, there were 34 (Kaplan-Meier estimate 4·0%) events of disabling stroke or death in the stenting group compared with 27 (3·2%) events in the endarterectomy group (hazard ratio [HR] 1·28, 95% CI 0·77-2·11). The incidence of stroke, death, or procedural myocardial infarction was 8·5% in the stenting group compared with 5·2% in the endarterectomy group (72 vs 44 events; HR 1·69, 1·16-2
- Published
- 2010
17. Prophylactic Perioperative Anti-Thrombotics in Open and Endovascular Abdominal Aortic Aneurysm (AAA) Surgery: A Systematic Review
- Author
-
Wiersema, A.M., primary, Jongkind, V., additional, Bruijninckx, C.M.A., additional, Reijnen, M.M.P.J., additional, Vos, J.A., additional, van Delden, O.M., additional, Zeebregts, C.J., additional, and Moll, F.L., additional
- Published
- 2012
- Full Text
- View/download PDF
18. Comment to: Huberts W, et al. A pulse wave propagation model to support decision-making in vascular access planning in the clinic [Med. Eng. Phys. 34 (2012) 233–248]
- Author
-
Bruijninckx, C.M.A., primary and van Gemert, M.J.C., additional
- Published
- 2012
- Full Text
- View/download PDF
19. Letter to Editor re: Dacron or PTFE for Above-knee Femoropopliteal Bypass. A Multicenter Randomised Study
- Author
-
Bruijninckx, C.M.A., primary
- Published
- 2007
- Full Text
- View/download PDF
20. Long-term Results of Primary Stent Placement to Treat Infrarenal Aortic Stenosis
- Author
-
Simons, P.C.G., primary, Nawijn, A.A., additional, Bruijninckx, C.M.A., additional, Knippenberg, B., additional, de Vries, E.H., additional, and van Overhagen, H., additional
- Published
- 2006
- Full Text
- View/download PDF
21. Endovascular irradiation for the prevention of restenosis after percutaneous transluminal angioplasty
- Author
-
Bruijninckx, C.M.A., primary and Levendag, P.C., additional
- Published
- 1998
- Full Text
- View/download PDF
22. Pre- en postoperatieve evaluatie van Claudicatio intermittens met behulp van een Doppler-flowmeter
- Author
-
Bruijninckx, C.M.A. and Radboud University Nijmegen
- Subjects
GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries) - Abstract
Contains fulltext : mmubn000001_156432773.pdf (Publisher’s version ) (Open Access) Promotor : P. Kuijpers 143 p., [6] bladen tek.
- Published
- 1976
23. Periprocedural antithrombotics in arterial procedures: The road to consensus
- Author
-
Wiersema, A.M., Moll, Frans L, Bruijninckx, C.M.A., Vos, J.A., and University Utrecht
- Subjects
interventional radiology ,aneurysm ,heparin ,anticoagulation ,antithrombotic agents ,Vascular surgery procedures - Abstract
In 1940 Murray published his paper on the role of “heparin in surgical treatment of blood vessels”. The introduction of heparin as a prophylactic antithrombotic in vascular surgery increased surgical interventions in the arterial circulation. Heparin reduces clotting of blood while clamping arteries and thereby reduces thrombo-embolic complications, local and systemic. Heparin is also considered essential during percutaneous endovascular interventions with balloons and stents. Heparin has a major, clinical, disadvantage: the prolonged clotting of blood causes an increase in bleeding complications, such as more blood loss and more blood transfusions. This also increases procedure time, leading to more (infectious) complications. The use of heparin can also lead to the development of heparin induced thrombocytopenia (HIT) syndrome, an unpredictable response of the immune system on the administration of heparin, possibly resulting in arterial and venous thrombo-embolic complications. Another major disadvantage of the use of heparin is the fact that heparin has no linear dose-response curve. This results in an unpredictable therapeutic effect in at least 20% of patients. This underlines the necessity of performing measurements of the actual effect of heparin, also because heparin is used worldwide in all open and endovascular arterial procedures. To develop new, evidence based guidelines for vascular surgery and interventional radiology (IR), a study group was instituted in the Netherlands (CAPPA: Consensus on Arterial PeriProcedural Anticoagulation). This study group performed 2 surveys on anticoagulation amongst Dutch vascular surgeons and IR. Results showed variation on the use of anticoagulation before, during and after arterial open and endovascular procedures. Predominantly heparin was used by most surgeons and IR during procedures as an prophylactic antithrombotic but the applied doses varied importantly. Also for IR, the variety found for the use of heparin in the Netherlands, was not the same as the variety found in the United Kingdom. Systematic reviews of literature on the use of heparin by vascular surgeons during open abdominal aortic aneurysm repair (AAA) and infra-inguinal bypass surgery (IABS) showed not much evidence for the beneficiary effect of heparin. During open AAA repair a trend was observed to harmful side effects such as more blood loss, longer operation time and more blood transfusion when heparin was used. Thrombo-embolic complications were not increased when no heparin was used. In the Netherlands a trial was performed to compare open and endovascular repair op AAA (DREAM trial). A sub-analysis from this trial in the open repair group showed no clinical differences in outcomes when heparin or no heparin was administered. The CAPPA group designed a randomized controlled trial (RCT) on the use of heparin during open AAA repair. Patients will be randomized to a heparin and a no-heparin group. Aim of this NANDA? trial (No Anticoagulation Needed During open AAA repair?), will be to determine if heparin is beneficial as an prophylactic antithrombotic. Multiple other trials on IABS and endovascular interventions are developed. Ultimate goal of these trials will be to create consensus and new guidelines on periprocedural prophylactic antithrombotics in arterial vascular surgery and IR.
- Published
- 2014
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