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416 results on '"Bruguerolle, B."'

24. Lack of daily rhythms major modifications despite continuous infusion of melatonin in the rat

Author

Vidal J, Bruguerolle B, Simon N, and J Mouchet

Subjects
Male, medicine.medical_specialty, Continuous infusion, Locomotor activity, Antioxidants, Melatonin, Rhythm, Heart Rate, Internal medicine, Heart rate, Medicine, Animals, Rats, Wistar, Pharmacology, Analysis of Variance, General Veterinary, Dose-Response Relationship, Drug, business.industry, Experimental model, Circadian Rhythm, Rats, Constant rate, Endocrinology, business, Locomotion, medicine.drug
Abstract

The present study was conducted to evaluate the effect of melatonin on the daily rhythms of temperature, heart rate and locomotor activity in rats that received subcutaneously a continuous infusion of two different doses e.g. 1 and 5 mg/kg per day for seven days. Our results indicate that melatonin does not induce a loss of the daily rhythmicity of temperature, heart rate and locomotor activity. Whatever the dose, melatonin slightly modifies the main parameters of these rhythms e.g. a decrease of the amplitude of the daily rhythms of temperature and heart rate and an increase of the mesor of temperature. Taking into account these results obtained after constant rate delivery in normal rats, we plan now to investigate the effects of melatnonin on our experimental model of Parkinson's disease (double bilateral intrastriatal 6-hydroxydopamine injection).

Published
2002

25. Influence of the menstrual cycle on theophylline pharmacokinetics in asthmatics

Author

H. Razzouk, M. Toumi, Bruguerolle B, Vervloet D, and Faraj F

Subjects
Adult, medicine.medical_specialty, medicine.drug_class, media_common.quotation_subject, Theophylline, Pharmacokinetics, Bronchodilator, Internal medicine, Blood plasma, Humans, Medicine, Asthmatic patient, Pharmacology (medical), Menstrual Cycle, Menstrual cycle, media_common, Pharmacology, Volume of distribution, business.industry, Airway Resistance, General Medicine, Asthma, Endocrinology, Plasma drug concentration, Female, business, Protein Binding, medicine.drug
Abstract

The effect of menstrual cycle on the pharmacokinetics of theophylline has been studied in 9 female asthmatic patients. At three different times during the cycle (first, tenth and twentieth days) each subject received an i.v. infusion of 240 mg theophylline. Significant changes were found in the kinetics of theophylline according to the menstrual cycle. The maximum plasma drug concentration, minimum mean residence time, and minimum elimination half-life were observed at mid-cycle. The lowest clearance was observed at D 20. The AUC and volume of distribution did not vary significantly during the cycle.

Published
1990

29. Correlations between theophylline concentrations in plasma, erythrocytes and cantharides-induced blister fluid and peak expiratory flow in asthma patients

Author

M Reynaud, A. Arnaud, F. Philip-Joet, and Bruguerolle B

Subjects
Male, Erythrocytes, medicine.drug_class, Peak Expiratory Flow Rate, Blister, Pharmacokinetics, Theophylline, Bronchodilator, Blood plasma, medicine, Humans, Pharmacology (medical), Infusions, Intravenous, Asthma, Pharmacology, Dose-Response Relationship, Drug, Chemistry, Respiratory disease, General Medicine, medicine.disease, Suction blister, Body Fluids, Red blood cell, medicine.anatomical_structure, Anesthesia, Cantharidin, medicine.drug
Abstract

Theophylline levels in plasma, erythrocytes and cantharides-induced blister fluid (BF) have been correlated with peak expiratory flow (PEF) in asthmatic patients. Nine asthmatic men received an IV infusion of 240 mg theophylline at a constant rate for 30 min. The theophylline concentrations in erythrocytes and blister fluid were 37% and 78% of those in plasma. There was not a strong correlation between erythrocyte or blister fluid penetration and the clinical effect of theophylline.

Published
1992

33. Effects of lorazepam on film-induced differentiated emotions in healthy volunteers.

Author

UCL, Garcia, C, Philippot, Pierre, Lacarelle, B, Valli, M, Rimé, Bernard, Bruguerolle, B, Blin, O, UCL, Garcia, C, Philippot, Pierre, Lacarelle, B, Valli, M, Rimé, Bernard, Bruguerolle, B, and Blin, O

Abstract

We studied the effects of lorazepam, a benzodiazepine, on differentiated emotions in healthy volunteers. In order to induce differentiated emotions, film excerpts were selected on the basis of the type of emotion they induced (fear, anger and for affective tone neutral film). For 6 days (D1 to D6), ten healthy volunteers received lorazepam (1 mg bid) or placebo in a randomized cross-over double-blind trial. During each treatment period, emotional induction occurred on D4, D5 and D6. One film excerpt (fear, anger or neutral) was presented each morning after relaxation. Evaluation was performed before and after each emotional induction and included questionnaires (Differential Emotions Scale and physical activation visual analog scales), and neurophysiological parameters (systolic and diastolic blood pressure, heart rate and norepinephrine levels). Globally, the film excerpts induced the predicted emotions. An analysis of variance was undertaken and revealed a significant effect of lorazepam versus placebo. On the Differential Emotions Scale and during fear induction, lorazepam induced a significantly higher increase in fear, anxiety and disgust emotions than placebo, whereas no effect was observed after anger induction. Lorazepam also induced a significantly higher increase in diastolic and systolic blood pressure with no change in heart rate, and physical activation items ("tears" and "faster breathing") without no significant change in norepinephrine. In conclusion, our results are consistent with an overall increase in emotional reactivity with lorazepam (1 mg bid) as compared to placebo. The pertinence of film-induced differentiated emotions has to be confirmed for clinical pharmacological use.

Published
1997

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