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1. One-Year Follow-Up Status of Treatment-Seeking Cocaine Abusers

Author

Bruge J. Rounsaville, Kendall J. Bryant, Mary-Ellen D. Power, and Kathleen M. Carroll

Subjects
Adult, Male, medicine.medical_specialty, Substance-Related Disorders, media_common.quotation_subject, Comorbidity, Severity of Illness Index, Outcome (game theory), Cocaine, Severity of illness, medicine, Humans, Risk factor, Psychiatry, Probability, media_common, Mental Disorders, Addiction, Abstinence, medicine.disease, Alcoholism, Psychiatry and Mental health, Treatment Outcome, Female, Opiate, Psychology, Follow-Up Studies, Psychopathology
Abstract

While the prognostic significance of comorbid psychopathology and dependence severity has been demonstrated with opiate addicts and alcoholics, no previous reports have examined these issues in cocaine abusers. We reinterviewed 94 cocaine abusers 1 year after they sought treatment to assess predictors of treatment retention and outcome. Results suggested that: a) Many cocaine abusers did comparatively well; fully a third reported complete abstinence during the 12 months preceding the follow-up interview. b) Three variables emerged as consistent predictors across several outcome domains: severity of drug use, poorer psychiatric functioning, and presence of concurrent alcoholism. c) The data supported a unidimensional model of outcome for cocaine abuse that emphasized reduction in level of substance use. However, abstinence was not strongly associated with improved functioning in all outcome areas. d) Variables associated with longer retention in treatment also tended to predict poorer outcome.

Published
1993
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2. Comparaison de l’activation des polynucléaires basophiles activés dans l’allergie alimentaire au cours d’un protocole d’induction de tolérance orale ou d’éviction allergénique par rapport aux enfants non allergiques

Author

Iliescu, C., primary, Decoster, A., additional, Deckmyn, B., additional, Dejardin, P., additional, Demilly, M., additional, Qu’-Huendu, V., additional, Paris, J., additional, Bruge, J., additional, Norberciak, L., additional, and Charpentier, A., additional

Published
2013
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6. OneYear FollowUp Status of TreatmentSeeking Cocaine Abusers

Author

CARROLL, KATHLEEN M., POWER, MARY-ELLEN D., BRYANT, KENDALL, and ROUNSAVILLE, BRUGE J.

Abstract

While the prognostic significance of eomorbid psychopathology and dependence severity has been demonstrated with opiate addicts and alcoholics, no previous reports have examined those issues in cocaine abusers. We reinterviewed 94 cocaine abusers 1 year after they sought treatment to assess predictors of treatment retention and outcome. Results suggested that: a) Many cocaine abusers did comparatively well; fully a third reported complete abstinence during the 12 months preceding the follow-up interview. b) Throe variables emerged as consistent predictors across several outcome domains: severity of drug use, poorer psychiatric functioning, and presence of concurrent alcoholism. c) The data supported a unidimensional model of outcome for cocaine abuse that emphasized reduction in level of substance use. However, abstinence was not strongly associated with improved functioning in all outcome areas. d) Variables associated with longer retention in treatment also tended to predict poorer outcome.

Published
1993

7. Characterisation of Asp669Tyr Piezo1 cation channel activity in red blood cells: an unexpected phenotype.

Author

Pérès L, Monedero Alonso D, Nudel M, Figeac M, Bruge J, Sebda S, Picard V, El Nemer W, Preudhomme C, Rose C, Egée S, and Bouyer G

Subjects
Anemia, Hemolytic, Congenital blood, Carbonyl Cyanide m-Chlorophenyl Hydrazone pharmacology, Child, Preschool, Erythrocyte Deformability, Gain of Function Mutation, Humans, Ion Channels genetics, Ion Transport, Male, Membrane Potentials drug effects, Osmolar Concentration, Osmotic Fragility, Patch-Clamp Techniques, Phenotype, Exome Sequencing, Amino Acid Substitution, Anemia, Hemolytic, Congenital genetics, Erythrocytes metabolism, Ion Channels blood, Mutation, Missense, Point Mutation, Potassium blood, Sodium blood
Published
2021
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9. Clinical evaluation of a group B meningococcal N-propionylated polysaccharide conjugate vaccine in adult, male volunteers.

Author

Bruge J, Bouveret-Le Cam N, Danve B, Rougon G, and Schulz D

Subjects
Adult, Animals, Antibodies, Bacterial analysis, Antibodies, Bacterial biosynthesis, Antibody Specificity, Autoantibodies analysis, Autoantibodies biosynthesis, Colony Count, Microbial, Cross Reactions, Enzyme-Linked Immunosorbent Assay, Humans, Immunization, Immunoglobulin G analysis, Immunoglobulin G biosynthesis, Immunoglobulin M analysis, Immunoglobulin M biosynthesis, Male, Meningococcal Infections prevention & control, Meningococcal Vaccines adverse effects, Mice, Neural Cell Adhesion Molecules immunology, Precipitin Tests, Rats, Vaccines, Conjugate adverse effects, Vaccines, Conjugate immunology, Meningococcal Vaccines immunology, Neisseria meningitidis, Serogroup B immunology, Polysaccharides immunology
Abstract

The safety and immunogenicity of a group B meningococcal vaccine, consisting of N-propionylated (NPr) B capsular polysaccharide conjugated to tetanus toxoid, was tested for the first time, in 17 healthy male volunteers aged between 18 and 40 years. Four escalating dosages of vaccine were tested and each was given as three intramuscular injections at 4-week intervals. The vaccine was well tolerated and induced only mild and transient, dose-dependent, injection-site reactions. One month after the last injection, there was no evidence of the production of autoantibodies or antibodies binding to PSA-NCAM. The vaccine induced an increase in the pre-existing titres of IgM specific to B polysaccharide and NPr B polysaccharide. Moreover, it induced IgG antibodies specific to NPr B polysaccharide, which were undetectable before vaccination. However, no functional activity of vaccine-induced antibodies was demonstrated in bactericidal assays, opsonophagocytic tests or passive protection tests.

Published
2004
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