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3. REACT: a randomized trial to assess the efficacy and safety of clazosentan for preventing clinical deterioration due to delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage

Author

Mayer, S, Bruder, N, Citerio, G, Defreyne, L, Dubois, C, Gupta, R, Higashida, R, Marr, A, Nguyen, T, Roux, S, Smrčka, M, Torné, R, Aldrich, E, Mayer, Stephan A, Bruder, Nicolas, Citerio, Giuseppe, Defreyne, Luc, Dubois, Cecile, Gupta, Rajiv, Higashida, Randall, Marr, Angelina, Nguyen, Thanh N, Roux, Sébastien, Smrčka, Martin, Torné, Ramon Torné, Aldrich, E François, Mayer, S, Bruder, N, Citerio, G, Defreyne, L, Dubois, C, Gupta, R, Higashida, R, Marr, A, Nguyen, T, Roux, S, Smrčka, M, Torné, R, Aldrich, E, Mayer, Stephan A, Bruder, Nicolas, Citerio, Giuseppe, Defreyne, Luc, Dubois, Cecile, Gupta, Rajiv, Higashida, Randall, Marr, Angelina, Nguyen, Thanh N, Roux, Sébastien, Smrčka, Martin, Torné, Ramon Torné, and Aldrich, E François

Abstract

Objective: Ischemic complications account for significant patient morbidity following aneurysmal subarachnoid hemorrhage (aSAH). The Prevention and Treatment of Vasospasm with Clazosentan (REACT) study was designed to assess the safety and efficacy of clazosentan, an endothelin receptor antagonist, in preventing clinical deterioration due to delayed cerebral ischemia (DCI) in patients with aSAH. Methods: REACT was a prospective, multicenter, randomized, double-blind, phase 3 study. Eligible patients had aSAH secured by surgical clipping or endovascular coiling, and had presented with thick and diffuse clot on admission CT scan. Patients were randomized (1:1 ratio) to 15 mg/hour intravenous clazosentan or placebo within 96 hours of the aSAH for up to 14 days, in addition to standard of care treatment including oral or intravenous nimodipine. The primary efficacy endpoint was the occurrence of clinical deterioration due to DCI up to 14 days after initiation of the study drug. The main secondary endpoint was the occurrence of clinically relevant cerebral infarction at day 16 after study drug initiation. Other secondary endpoints included clinical outcome assessed on the modified Rankin Scale (mRS) and the Glasgow Outcome Scale-Extended (GOSE) at week 12 post-aSAH. Imaging and clinical endpoints were centrally adjudicated. Results: A total of 409 patients were randomized between February 2019 and May 2022 across 74 international sites. Three patients did not start study treatment and were not included in the analysis set. The occurrence of clinical deterioration due to DCI was 15.8% (32/202 patients) in the clazosentan group and 17.2% (35/204 patients) in the placebo group, and the difference was not statistically significant (relative risk reduction [RRR] 7.2%, 95% CI -42.6% to 39.6%, p = 0.734). A nonsignificant RRR of 34.1% (95% CI -21.3% to 64.2%, p = 0.177) was observed in clinically relevant cerebral infarcts treated with clazosentan (7.4%, 15/202) versus placebo

Published
2024

6. A multicentre observational study on management of general anaesthesia in elderly patients at high-risk of postoperative adverse outcomes

Author

Bruder, N., Vaisse, C., Bechis, C., Bernard, L., Leone, M., Poirier, M., Vincent, A., Abdelkrim, N., Paugam, C., Lion, F., Montravers, P., Langeron, O., Raux, M., Baussier, M., Xu, K., Bart, F., Dagois, S., Plaud, B., Rabuel, C., Roland, E., Biais, M., Nouette-Gaulain, K., Cabart, A., Hanouz, J.L., Lambert, C., Godet, T., Thibault, S., Bouhemad, B., Chambade, E., Bouzat, P., Garot, M., Lebuffe, G., Lallemant, F., Lemery, C., Tavernier, B., de Jong, A., Jaber, S., Verzilli, D., Delannoy, M., Meistelman, C., Carles, M., Tran, L., Bertran, S., Cuvillon, P., Ripart, J., Simon-Pene, S., Boisson, M., Debaene, B., Beloeil, H., Godet, G., Collange, O., Mertes, P.M., Diemunsch, P., Joganah, D., Oehlkern, L., Baulieu, M., Beauchesne, B., Beraud, A.M., Berthier-Berrada, S., Bien, J.Y., Dupont, G., Gavory, J., Lambert, P., Lanoiselée, J., Zufferey, P., Ferré, F., Martin, C., Minville, V., Planté, B., Baffeleuf, B., Ben Abdelkarim, M., David, J.S., Incagnoli, P., Khaled, M., Laplace, M.C., Lefevre, M., Piriou, V., Aubrun, F., Cero, V., Delsuc, C., Faulcon, C., Meuret, P., Rimmelé, T., Truc, C., Molliex, Serge, Passot, Sylvie, Morel, Jerome, Futier, Emmanuel, Lefrant, Jean Yves, Constantin, Jean Michel, Le Manach, Yannick, and Pereira, Bruno

Published
2019
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7. Reducing the carbon footprint of general anaesthesia: a comparison of total intravenous anaesthesia vs. a mixed anaesthetic strategy in 47,157 adult patients.

Author

Bernat, M., Boyer, A., Roche, M., Richard, C., Bouvet, L., Remacle, A., Antonini, F., Poirier, M., Pastene, B., Hammad, E., Fond, G., Bruder, N., Leone, M., and Zieleskiewicz, L.

Subjects
ECOLOGICAL impact, ANESTHETICS, HYPNOTICS, ANESTHESIA, CARBON dioxide
Abstract

Summary: Global warming is a major public health concern. Volatile anaesthetics are greenhouse gases that increase the carbon footprint of healthcare. Modelling studies indicate that total intravenous anaesthesia is less carbon intensive than volatile anaesthesia, with equivalent quality of care. In this observational study, we aimed to apply the findings of previous modelling studies to compare the carbon footprint per general anaesthetic of an exclusive TIVA strategy vs. a mixed TIVA‐volatile strategy. This comparative retrospective study was conducted over 2 years in two French hospitals, one using total intravenous anaesthesia only and one using a mixed strategy including both intravenous and inhalation anaesthetic techniques. Based on pharmacy procurement records, the quantity of anaesthetic sedative drugs was converted to carbon dioxide equivalents. The primary outcome was the difference in carbon footprint of hypnotic drugs per intervention between the two strategies. From 1 January 2021 to 31 December 2022, 25,137 patients received general anaesthesia in the hospital using the total intravenous anaesthesia strategy and 22,020 in the hospital using the mixed strategy. The carbon dioxide equivalent footprint of hypnotic drugs per intervention in the hospital using the total intravenous anaesthesia strategy was 20 times lower than in the hospital using the mixed strategy (emissions of 2.42 kg vs. 48.85 kg carbon dioxide equivalent per intervention, respectively). The total intravenous anaesthesia strategy significantly reduces the carbon footprint of hypnotic drugs in general anaesthesia in adult patients compared with a mixed strategy. Further research is warranted to assess the risk–benefit ratio of the widespread adoption of total intravenous anaesthesia. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Antifungal therapy for patients with proven or suspected Candida peritonitis: Amarcand2, a prospective cohort study in French intensive care units

Author

Aait Hssain, A., Adda, M., Allaouchiche, B., Ammenouche, N., Angel, G., Argaud, L., Badetti, C., Baldesi, O., Barthet, M.C., Bastien, O., Baudin, F., Bellec, F., Blasco, G., Bollaert, P.E., Bonadona, A., Bretonniere, C., Brocas, E., Brua, S., Bruder, N., Brunin, G., Cabaret, P., Carpentier, D., Cartier, J.C., Cerf, C., Chabanne, R., Charles, P.E., Cheval, C., Cinotti, R., Cohen, Y., Cousson, J., Delpierre, E., Demory, D., Diconne, E., Du Cheyron, D., Dubost, C., Dumenil, A.S., Durand, M., Duroy, E., Forel, J.M., Foucher-Lezla, A.L., Fratea, S., Gally, J., Gaudard, P., Geffe, P., Gergaud, S., Gette, S., Girault, C., Goubaux, B., Gouin, P., Grenot, R., Grossmith, G., Guelon, D., Guerin-Robardey, A.M., Guervilly, C., Hayl-Slayman, D., Hilbert, G., Houissa, H., Hraiech, S., Ichai, P., Jung, B., Kaidomar, M., Karoubi, P., Kherchache, A., Lambiotte, F., Lamhaut, L., Launoy, A., Lebreton, F., Lefrant, J.Y., Lemaire, C., Lepape, A., Lepoivre, T., Lesieur, O., Levy, B., Luyt, C.E., Mahe, P.J., Mahul, P., Mateu, P., Megarbane, B., Merle, J.C., Montcriol, A., Mootien, Y., Navellou, J.C., Ouattara, A., Page, B., Petitpas, F., Plantefeve, G., Quinart, A., Quintard, H., Ragonnet, B., Roquilly, A., Ruiz, J., Saliba, F., Samba, D., Schmitt, Z., Seguin, P., Sejourne, C., Tellier, A.C., Thevenot, F., Tonnelier, J.M., Van Grunderbeek, N., Vincent, J.F., Wiramus, S., Zogheib, E., Montravers, P., Perrigault, P.F., Timsit, J.F., Mira, J.P., Lortholary, O., Leroy, O., Gangneux, J.P., Guillemot, D., Bensoussan, C., Bailly, S., Azoulay, E., Constantin, J.M., and Dupont, H.

Published
2017
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18. ESICM LIVES 2016: part one: Milan, Italy. 1-5 October 2016

Author

Bos, L., Schouten, L., van Vught, L., Wiewel, M., Ong, D., Cremer, O., Artigas, A., Martin-Loeches, I., Hoogendijk, A., van der Poll, T., Horn, J., Juffermans, N., Schultz, M., de Prost, N., Pham, T., Carteaux, G., Dessap, A. Mekontso, Brun-Buisson, C., Fan, E., Bellani, G., Laffey, J., Mercat, A., Brochard, L., Maitre, B., Howells, P. A., Thickett, D. R., Knox, C., Park, D. P., Gao, F., Tucker, O., Whitehouse, T., McAuley, D. F., Perkins, G. D., Pham, T., Laffey, J., Bellani, G., Fan, E., Pisani, L., Roozeman, J. P., Simonis, F. D., Giangregorio, A., Schouten, L. R., Van der Hoeven, S. M., Horn, J., Neto, A. Serpa, Festic, E., Dondorp, A. M., Grasso, S., Bos, L. D., Schultz, M. J., Koster-Brouwer, M., Verboom, D., Scicluna, B., van de Groep, K., Frencken, J., Schultz, M., van der Poll, T., Bonten, M., Cremer, O., Ko, J. I., Kim, K. S., Suh, G. J., Kwon, W. Y., Kim, K., Shin, J. H., Ranzani, O. T., Prina, E., Menendez, R., Ceccato, A., Mendez, R., Cilloniz, C., Gabarrus, A., Ferrer, M., Torres, A., Urbano, A., Zhang, L. A., Swigon, D., Pike, F., Parker, R. S., Clermont, G., Scheer, C., Kuhn, S. O., Modler, A., Vollmer, M., Fuchs, C., Hahnenkamp, K., Rehberg, S., Gründling, M., Taggu, A., Darang, N., Öveges, N., László, I., Tánczos, K., Németh, M., Lebák, G., Tudor, B., Érces, D., Kaszaki, J., Huber, W., Trásy, D., Molnár, Z., Ferrara, G., Edul, V. S. Kanoore, Canales, H. S., Martins, E., Canullán, C., Murias, G., Pozo, M. O., Eguillor, J. F. Caminos, Buscetti, M. G., Ince, C., Dubin, A., Aya, H. D., Rhodes, A., Fletcher, N., Grounds, R. M., Cecconi, M., Jacquet-Lagrèze, M., Riche, M., Schweizer, R., Portran, P., Fornier, W., Lilot, M., Neidecker, J., Fellahi, J. L., Escoresca-Ortega, A., Gutiérrez-Pizarraya, A., Charris-Castro, L., Corcia-Palomo, Y., Fernandez-Delgado, E., Garnacho-Montero, J., Roger, C., Muller, L., Elotmani, L., Lipman, J., Lefrant, J. Y., Roberts, J. A., Muñoz-Bermúdez, R., Samper, M., Climent, C., Vasco, F., Sara, V., Luque, S., Campillo, N., Cerrato, S. Grau, Masclans, J. R., Alvarez-Lerma, F., Brugger, S. Carvalho, Jimenez, G. Jimenez, Torner, M. Miralbés, Cabello, J. Trujillano, Garrido, B. Balsera, Casals, X. Nuvials, Gaite, F. Barcenilla, Vidal, M. Vallverdú, Martínez, M. Palomar, Gusarov, V., Shilkin, D., Dementienko, M., Nesterova, E., Lashenkova, N., Kuzovlev, A., Zamyatin, M., Demoule, A., Carreira, S., Lavault, S., Palancca, O., Morawiec, E., Mayaux, J., Arnulf, I., Similowski, T., Rasmussen, B. S., Maltesen, R. G., Hanifa, M., Pedersen, S., Kristensen, S. R., Wimmer, R., Panigada, M., Bassi, G. Li, Ranzani, O. T., Kolobow, T., Zanella, A., Cressoni, M., Berra, L., Parrini, V., Kandil, H., Salati, G., Livigni, S., Amatu, A., Andreotti, A., Tagliaferri, F., Moise, G., Mercurio, G., Costa, A., Vezzani, A., Lindau, S., Babel, J., Cavana, M., Consonni, D., Pesenti, A., Gattinoni, L., Torres, A., Mansouri, P., Zand, F., Zahed, L., Dehghanrad, F., Bahrani, M., Ghorbani, M., Cambiaghi, B., Moerer, O., Mauri, T., Kunze-Szikszay, N., Ritter, C., Pesenti, A., Quintel, M., Vilander, L. M., Kaunisto, M. A., Vaara, S. T., Pettilä, V., Mulier, J. L. G. Haitsma, Rozemeijer, S., Spoelstra-de Man, A. M. E., Elbers, P. E., Tuinman, P. R., de Waard, M. C., Oudemans-van Straaten, H. M., Liberatore, A. M. A., Souza, R. B., Martins, A. M. C. R. P. F., Vieira, J. C. F., Koh, I. H. J., Martínez, M. Galindo, Sánchez, R. Jiménez, Gascón, L. Martínez, Mulero, M. D. Rodríguez, Freire, A. Ortín, Muñoz, A. Ojados, Acebes, S. Rebollo, Martínez, Á. Fernández, Aliaga, S. Moreno, Para, L. Herrera, Payá, J. Murcia, Mulero, F. Rodríguez, Guerci, P., Ince, Y., Heeman, P., Ergin, B., Ince, C., Uz, Z., Massey, M., Ince, Y., Papatella, R., Bulent, E., Guerci, P., Toraman, F., Ince, C., Longbottom, E. R., Torrance, H. D., Owen, H. C., Hinds, C. J., Pearse, R. M., O’Dywer, M. J., Trogrlic, Z., van der Jagt, M., Lingsma, H., Ponssen, H. H., Schoonderbeek, J. F., Schreiner, F., Verbrugge, S. J., Duran, S., van Achterberg, T., Bakker, J., Gommers, D. A. M. P. J., Ista, E., Krajčová, A., Waldauf, P., Duška, F., Shah, A., Roy, N., McKechnie, S., Doree, C., Fisher, S., Stanworth, S. J., Jensen, J. F., Overgaard, D., Bestle, M. H., Christensen, D. F., Egerod, I., Pivkina, A., Gusarov, V., Zhivotneva, I., Pasko, N., Zamyatin, M., Jensen, J. F., Egerod, I., Bestle, M. H., Christensen, D. F., Alklit, A., Hansen, R. L., Knudsen, H., Grode, L. B., Overgaard, D., Hravnak, M., Chen, L., Dubrawski, A., Clermont, G., Pinsky, M. R., Parry, S. M., Knight, L. D., Connolly, B. C., Baldwin, C. E., Puthucheary, Z. A., Denehy, L., Hart, N., Morris, P. E., Mortimore, J., Granger, C. L., Jensen, H. I., Piers, R., Van den Bulcke, B., Malmgren, J., Metaxa, V., Reyners, A. K., Darmon, M., Rusinova, K., Talmor, D., Meert, A. P., Cancelliere, L., Zubek, L., Maia, P., Michalsen, A., Decruyenaere, J., Kompanje, E., Vanheule, S., Azoulay, E., Vansteelandt, S., Benoit, D., Van den Bulcke, B., Piers, R., Jensen, H. I., Malmgren, J., Metaxa, V., Reyners, A. K., Darmon, M., Rusinova, K., Talmor, D., Meert, A. P., Cancelliere, L., Zubek, L., Maia, P., Michalsen, A., Decruyenaere, J., Kompanje, E., Vanheule, S., Azoulay, E., Vansteelandt, S., Benoit, D., Ryan, C., Dawson, D., Ball, J., Noone, K., Aisling, B., Prudden, S., Ntantana, A., Matamis, D., Savvidou, S., Giannakou, M., Gouva, M., Nakos, G., Koulouras, V., Aron, J., Lumley, G., Milliken, D., Dhadwal, K., McGrath, B. A., Lynch, S. J., Bovento, B., Sharpe, G., Grainger, E., Pieri-Davies, S., Wallace, S., McGrath, B., Lynch, S. J., Bovento, B., Grainger, E., Pieri-Davies, S., Sharpe, G., Wallace, S., Jung, M., Cho, J., Park, H., Suh, G., Kousha, O., Paddle, J., Gripenberg, L. Gamrin, Rehal, M. Sundström, Wernerman, J., Rooyackers, O., de Grooth, H. J., Choo, W. P., Spoelstra-de Man, A. M., Swart, E. L., Oudemans-van Straaten, H. M., Talan, L., Güven, G., Altıntas, N. D., Padar, M., Uusvel, G., Starkopf, L., Starkopf, J., Blaser, A. Reintam, Kalaiselvan, M. S., Arunkumar, A. S., Renuka, M. K., Shivkumar, R. L., Volbeda, M., ten Kate, D., Hoekstra, M., van der Maaten, J. M., Nijsten, M. W., Komaromi, A., Rooyackers, O., Wernerman, J., Norberg, Å., Smedberg, M., Mori, M., Pettersson, L., Norberg, Å., Rooyackers, O., Wernerman, J., Theodorakopoulou, M., Christodoulopoulou, T., Diamantakis, A., Frantzeskaki, F., Kontogiorgi, M., Chrysanthopoulou, E., Lygnos, M., Diakaki, C., Armaganidis, A., Gundogan, K., Dogan, E., Coskun, R., Muhtaroglu, S., Sungur, M., Ziegler, T., Guven, M., Kleyman, A., Khaliq, W., Andreas, D., Singer, M., Meierhans, R., Schuepbach, R., De Brito-Ashurst, I., Zand, F., Sabetian, G., Nikandish, R., Hagar, F., Masjedi, M., Maghsudi, B., Vazin, A., Ghorbani, M., Asadpour, E., Kao, K. C., Chiu, L. C., Hung, C. Y., Chang, C. H., Li, S. H., Hu, H. C., El Maraghi, S., Ali, M., Rageb, D., Helmy, M., Marin-Corral, J., Vilà, C., Masclans, J. R., Vàzquez, A., Martín-Loeches, I., Díaz, E., Yébenes, J. C., Rodriguez, A., Álvarez-Lerma, F., Varga, N., Cortina-Gutiérrez, A., Dono, L., Martínez-Martínez, M., Maldonado, C., Papiol, E., Pérez-Carrasco, M., Ferrer, R., Nweze, K., Morton, B., Welters, I., Houard, M., Voisin, B., Ledoux, G., Six, S., Jaillette, E., Nseir, S., Romdhani, S., Bouneb, R., Loghmari, D., Aicha, N. Ben, Ayachi, J., Meddeb, K., Chouchène, I., Khedher, A., Boussarsar, M., Chan, K. S., Yu, W. L., Marin-Corral, J., Vilà, C., Masclans, J. R., Nolla, J., Vidaur, L., Bonastre, J., Suberbiola, B., Guerrero, J. E., Rodriguez, A., Coll, N. Ramon, Jiménez, G. Jiménez, Brugger, S. Carvalho, Calero, J. Codina, Garrido, B. Balsera, García, M., Martínez, M. Palomar, Vidal, M. Vallverdú, de la Torre, M. C., Vendrell, E., Palomera, E., Güell, E., Yébenes, J. C., Serra-Prat, M., Bermejo-Martín, J. F., Almirall, J., Tomas, E., Escoval, A., Froe, F., Pereira, M. H. Vitoria, Velez, N., Viegas, E., Filipe, E., Groves, C., Reay, M., Chiu, L. C., Hu, H. C., Hung, C. Y., Chang, C. H., Li, S. H., Kao, K. C., Ballin, A., Facchin, F., Sartori, G., Zarantonello, F., Campello, E., Radu, C. M., Rossi, S., Ori, C., Simioni, P., Umei, N., Shingo, I., Santos, A. C., Candeias, C., Moniz, I., Marçal, R., e Silva, Z. Costa, Ribeiro, J. M., Georger, J. F., Ponthus, J. P., Tchir, M., Amilien, V., Ayoub, M., Barsam, E., Martucci, G., Panarello, G., Tuzzolino, F., Capitanio, G., Ferrazza, V., Carollo, T., Giovanni, L., Arcadipane, A., Sánchez, M. López, González-Gay, M. A., Díaz, F. J. Llorca, López, M. I. Rubio, Zogheib, E., Villeret, L., Nader, J., Bernasinski, M., Besserve, P., Caus, T., Dupont, H., Morimont, P., Habran, S., Hubert, R., Desaive, T., Blaffart, F., Janssen, N., Guiot, J., Pironet, A., Dauby, P., Lambermont, B., Zarantonello, F., Ballin, A., Facchin, F., Sartori, G., Campello, E., Pettenuzzo, T., Citton, G., Rossi, S., Simioni, P., Ori, C., Kirakli, C., Ediboglu, O., Ataman, S., Yarici, M., Tuksavul, F., Keating, S., Gibson, A., Gilles, M., Dunn, M., Price, G., Young, N., Remeta, P., Bishop, P., Zamora, M. D. Fernández, Muñoz-Bono, J., Curiel-Balsera, E., Aguilar-Alonso, E., Hinojosa, R., Gordillo-Brenes, A., Arboleda-Sánchez, J. A., Skorniakov, I., Vikulova, D., Whiteley, C., Shaikh, O., Jones, A., Ostermann, M., Forni, L., Scott, M., Sahatjian, J., Linde-Zwirble, W., Hansell, D., Laoveeravat, P., Srisawat, N., Kongwibulwut, M., Peerapornrattana, S., Suwachittanont, N., Wirotwan, T. O., Chatkaew, P., Saeyub, P., Latthaprecha, K., Tiranathanagul, K., Eiam-ong, S., Kellum, J. A., Berthelsen, R. E., Perner, A., Jensen, A. E. K., Jensen, J. U., Bestle, M. H., Gebhard, D. J., Price, J., Kennedy, C. E., Akcan-Arikan, A., Liberatore, A. M. A., Souza, R. B., Martins, A. M. C. R. P. F., Vieira, J. C. F., Kang, Y. R., Nakamae, M. N., Koh, I. H. J., Hamed, K., Khaled, M. M., Soliman, R. Aly, Mokhtar, M. Sherif, Seller-Pérez, G., Arias-Verdú, D., Llopar-Valdor, E., De-Diós-Chacón, I., Quesada-García, G., Herrera-Gutierrez, M. E., Hafes, R., Carroll, G., Doherty, P., Wright, C., Vera, I. G. Guerra, Ralston, M., Gemmell, M. L., MacKay, A., Black, E., Wright, C., Docking, R. I., Appleton, R., Ralston, M. R., Gemmell, L., Appleton, R., Wright, C., Docking, R. I., Black, E., Mackay, A., Rozemeijer, S., Mulier, J. L. G. Haitsma, Röttgering, J. G., Elbers, P. W. G., Spoelstra-de Man, A. M. E., Tuinman, P. R., de Waard, M. C., Oudemans-van Straaten, H. M., Mejeni, N., Nsiala, J., Kilembe, A., Akilimali, P., Thomas, G., Egerod, I., Andersson, A. E., Fagerdahl, A. M., Knudsen, V., Meddeb, K., Cheikh, A. Ben, Hamdaoui, Y., Ayachi, J., Guiga, A., Fraj, N., Romdhani, S., Sma, N., Bouneb, R., Chouchene, I., Khedher, A., Bouafia, N., Boussarsar, M., Amirian, A., Ziaian, B., Masjedi, M., Fleischmann, C., Thomas-Rueddel, D. O., Schettler, A., Schwarzkopf, D., Stacke, A., Reinhart, K., Filipe, E., Escoval, A., Martins, A., Sousa, P., Velez, N., Viegas, E., Tomas, E., Snell, G., Matsa, R., Paary, T. T. S., Kalaiselvan, M. S., Cavalheiro, A. M., Rocha, L. L., Vallone, C. S., Tonilo, A., Lobato, M. D. S., Malheiro, D. T., Sussumo, G., Lucino, N. M., Zand, F., Rosenthal, V. D., Masjedi, M., Sabetian, G., Maghsudi, B., Ghorbani, M., Dashti, A. Sanaei, Yousefipour, A., Goodall, J. R., Williamson, M., Tant, E., Thomas, N., Balci, C., Gonen, C., Haftacı, E., Gurarda, H., Karaca, E., Paldusová, B., Zýková, I., Šímová, D., Houston, S., D’Antona, L., Lloyd, J., Garnelo-Rey, V., Sosic, M., Sotosek-Tokmazic, V., Kuharic, J., Antoncic, I., Dunatov, S., Sustic, A., Chong, C. T., Sim, M., Lyovarin, T., Díaz, F. M. Acosta, Galdó, S. Narbona, Garach, M. Muñoz, Romero, O. Moreno, Bailón, A. M. Pérez, Pinel, A. Carranza, Colmenero, M., Gritsan, A., Gazenkampf, A., Korchagin, E., Dovbish, N., Lee, R. M., Lim, M. P. P., Chong, C. T., Lim, B. C. L., See, J. J., Assis, R., Filipe, F., Lopes, N., Pessoa, L., Pereira, T., Catorze, N., Aydogan, M. S., Aldasoro, C., Marchio, P., Jorda, A., Mauricio, M. D., Guerra-Ojeda, S., Gimeno-Raga, M., Colque-Cano, M., Bertomeu-Artecero, A., Aldasoro, M., Valles, S. L., Tonon, D., Triglia, T., Martin, J. C., Alessi, M. 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R., Parenti, N., Agrusta, F., Palazzi, C., Pifferi, B., Sganzerla, R., Tagliazucchi, F., Luciani, A., Möller, M., Müller-Engelmann, J., Montag, G., Adams, P., Lange, C., Neuzner, J., Gradaus, R., Wodack, K. H., Thürk, F., Waldmann, A. D., Grässler, M. F., Nishimoto, S., Böhm, S. H., Kaniusas, E., Reuter, D. A., Trepte, C. J., Sigmundsson, T., Öhman, T., Redondo, E., Hallbäck, M., Wallin, M., Sipman, F. Suarez, Oldner, A., Sander, C. Hällsjö, Björne, H., Colinas, L., Hernandez, G., Vicho, R., Serna, M., Cuena, R., Canabal, A., Chaari, A., Hakim, K. Abdel, Etman, M., El Bahr, M., El Sakka, A., Bousselmi, K., Arali, A., Kauts, V., Casey, W. F., Bond, O., De Santis, P., Iesu, E., Franchi, F., Vincent, J. L., Creteur, J., Scolletta, S., Taccone, F. S., Marutyan, Z., Hamidova, L., Shakotko, A., Movsisyan, V., Uysupova, I., Evdokimov, A., Petrikov, S., Gonen, C., Haftacı, E., Balci, C., Calvo, F. J. Redondo, Bejarano, N., Baladron, V., Villazala, R., Redondo, J., Padilla, D., Villarejo, P., Akcan-Arikan, A., Kennedy, C. E., Arzapalo, M. F. Aguilar, Gomez-Gonzalez, C., Mas-Font, S., Puppo-Moreno, A., Herrera-Gutierrez, M., Garcia-Garcia, M., Aldunate-Calvo, S., Plata-Menchaca, E. P., Pérez-Fernández, X. L., Estruch, M., Betbese-Roig, A., Campos, P. Cárdenas, Lora, M. Rojas, Gaibor, N. D. Toapanta, Medina, R. S. Contreras, Sanguino, V. D. Gumucio, Casanova, E. J., Riera, J. Sabater, Kritmetapak, K., Peerapornratana, S., Kittiskulnam, P., Dissayabutra, T., Tiranathanagul, K., Susantithapong, P., Praditpornsilpa, K., Tungsanga, K., Eiam-Ong, S., Srisawat, N., Winkelmann, T., Busch, T., Meixensberger, J., Bercker, S., Cabeza, E. M. Flores, Sánchez, M. Sánchez, Giménez, N. Cáceres, Melón, C. Gutierrez, de Lucas, E. Herrero, Estañ, P. Millán, Bernal, M. Hernández, de Lorenzo y Mateos, A. Garcia, Ergin, B., Guerci, P., Specht, P. A. C., Ince, Y., Ince, C., Balik, M., Zakharchenko, M., Los, F., Brodska, H., de Tymowski, C., Augustin, P., Desmard, M., Montravers, P., Stapel, S. N., de Boer, R., Oudemans, H. M., Hollinger, A., Schweingruber, T., Jockers, F., Dickenmann, M., Siegemund, M., Runciman, N., Ralston, M., Appleton, R., Mauri, T., Alban, L., Turrini, C., Sasso, T., Langer, T., Panigada, M., Taccone, P., Carlesso, E., Marenghi, C., Grasselli, G., Pesenti, A., Wibart, P., Reginault, T., Garcia, M., Barbrel, B., Benard, A., Bader, C., Vargas, F., Bui, H. N., Hilbert, G., Simón, J. M. Serrano, Sánchez, P. Carmona, Ferrón, F. Ruiz, de Acilu, M. García, Marin, J., Antonia, V., Ruano, L., Monica, M., Ferrer, R., Masclans, J. R., Roca, O., Hong, G., Kim, D. H., Kim, Y. S., Park, J. S., Jee, Y. K., xiang, Z. Yu, Jia-xing, W., dan, W. Xiao, long, N. Wen, Yu, W., Yan, Z., Cheng, X., Kobayashi, T., Onodera, Y., Akimoto, R., Sugiura, A., Suzuki, H., Iwabuchi, M., Nakane, M., Kawamae, K., Sanchez, P. Carmona, Rodriguez, M. D. Bautista, Delgado, M. Rodriguez, Sánchez, V. Martínez de Pinillos, Gómez, A. Mula, Simón, J. M. Serrano, Beuret, P., Fortes, C., Lauer, M., Reboul, M., Chakarian, J. C., Fabre, X., Philippon-Jouve, B., Devillez, S., Clerc, M., Rittayamai, N., Sklar, M., Dres, M., Rauseo, M., Campbell, C., West, B., Tullis, D. E., Brochard, L., Onodera, Y., Akimoto, R., Suzuki, H., Okada, M., Nakane, M., Kawamae, K., Ahmad, N., Wood, M., Glossop, A., Lucas, J. Higuera, Ortiz, A. Blandino, Alonso, D. Cabestrero, De Pablo Sánchez, R., González, L. Rey, Costa, R., Spinazzola, G., Pizza, A., Ferrone, G., Rossi, M., Antonelli, M., Conti, G., Ribeiro, H., Alves, J., Sousa, M., Reis, P., Socolovsky, C. S., Cauley, R. P., Frankel, J. E., Beam, A. L., Olaniran, K. O., Gibbons, F. K., Christopher, K. B., Pennington, J., Zolfaghari, P., King, H. S., Kong, H. H. Y., Shum, H. P., Yan, W. W., Kaymak, C., Okumus, N., Sari, A., Erdogdu, B., Aksun, S., Basar, H., Ozcan, A., Ozcan, N., Oztuna, D., Malmgren, J. A., Lundin, S., Torén, K., Eckerström, M., Wallin, A., Waldenström, A. C., Riccio, F. C., Pogson, D., Antonio, A. C. P., Leivas, A. F., Kenji, F., James, E., Morgan, P., Carroll, G., Gemmell, L., MacKay, A., Wright, C., Ballantyne, J., Jonnada, S., Gerrard, C. S., Jones, N., Salciccioli, J. D., Marshall, D. C., Komorowski, M., Hartley, A., Sykes, M. C., Goodson, R., Shalhoub, J., Villanueva, J. R. Fernández, Garda, R. Fernández, Lago, A. M. López, Ruiz, E. Rodríguez, Vaquero, R. Hernández, Rodríguez, C. Galbán, Pérez, E. Varo, Hilasque, C., Oliva, I., Sirgo, G., Martin, M. C., Olona, M., Gilavert, M. C., Bodí, M., Ebm, C., Aggarwal, G., Huddart, S., Quiney, N., Cecconi, M., Fernandes, S. M., Silva, J. Santos, Gouveia, J., Silva, D., Marques, R., Bento, H., Alvarez, A., Silva, Z. Costa, Diaz, D. Díaz, Martínez, M. Villanova, Herrejon, E. Palencia, de la Gandara, A. Martinez, Gonzalo, G., Lopez, M. A., de Gopegui Miguelena, P. Ruíz, Matilla, C. I. Bernal, Chueca, P. Sánchez, Longares, M. D. C. Rodríguez, Abril, R. Ramos, Aguilar, A. L. Ruíz, de Murillas, R. Garrido López, Fernández, R. Fernández, Laborías, P. Morales, Castellanos, M. A. Díaz, Laborías, M. E. Morales, Cho, J., Kim, J., Park, J., Woo, S., West, T., Powell, E., Rimmer, A., Orford, C., Jones, N., Williams, J., Matilla, C. I. Bernal, de Gopegui Miguelena, P. Ruiz, Chueca, P. Sánchez, Abril, R. Ramos, Longares, M. D. C. Rodríguez, Aguilar, A. L. Ruíz, de Murillas, R. Garrido López, Bourne, R. S., Shulman, R., Tomlin, M., Mills, G. H., Borthwick, M., Berry, W., Huertas, D. García, Manzano, F., Villagrán-Ramírez, F., Ruiz-Perea, A., Rodríguez-Mejías, C., Santiago-Ruiz, F., Colmenero-Ruiz, M., König, C., Matt, B., Kortgen, A., Hartog, C. S., Wong, A., Balan, C., Barker, G., Srisawat, N., Peerapornratana, S., Laoveeravat, P., Tachaboon, S., Eiam-ong, S., Paratz, J., Kayambu, G., Boots, R., Arzapalo, M. F. Aguilar, Vlasenko, R., Gromova, E., Loginov, S., Kiselevskiy, M., Dolgikova, Y., Tang, K. B., Chau, C. M., Lam, K. N., Gil, E., Suh, G. Y., Park, C. M., Park, J., Chung, C. R., Lee, C. T., Chao, A., Shih, P. Y., Chang, Y. F., Lai, C. H., Hsu, Y. C., Yeh, Y. C., Cheng, Y. J., Colella, V., Zarrillo, N., D’Amico, M., Forfori, F., Pezza, B., Laddomada, T., Beltramelli, V., Pizzaballa, M. L., Doronzio, A., Balicco, B., Kiers, D., van der Heijden, W., Gerretsen, J., de Mast, Q., el Messaoudi, S., Rongen, G., Gomes, M., Kox, M., Pickkers, P., Riksen, N. P., Kashiwagi, Y., Okada, M., Hayashi, K., Inagaki, Y., Fujita, S., Nakamae, M. N., Kang, Y. R., Souza, R. B., Liberatore, A. M. A., Koh, I. H. J., Blet, A., Sadoune, M., Lemarié, J., Bihry, N., Bern, R., Polidano, E., Merval, R., Launay, J. M., Lévy, B., Samuel, J. L., Mebazaa, A., Hartmann, J., Harm, S., and Weber, V.

Published
2016
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20. Mechanical ventilation in patients with acute brain injury: recommendations of the European Society of Intensive Care Medicine consensus

Author

Robba, C. Poole, D. McNett, M. Asehnoune, K. Bösel, J. Bruder, N. Chieregato, A. Cinotti, R. Duranteau, J. Einav, S. Ercole, A. Ferguson, N. Guerin, C. Siempos, I.I. Kurtz, P. Juffermans, N.P. Mancebo, J. Mascia, L. McCredie, V. Nin, N. Oddo, M. Pelosi, P. Rabinstein, A.A. Neto, A.S. Seder, D.B. Skrifvars, M.B. Suarez, J.I. Taccone, F.S. van der Jagt, M. Citerio, G. Stevens, R.D.

Abstract

Purpose: To provide clinical practice recommendations and generate a research agenda on mechanical ventilation and respiratory support in patients with acute brain injury (ABI). Methods: An international consensus panel was convened including 29 clinician-scientists in intensive care medicine with expertise in acute respiratory failure, neurointensive care, or both, and two non-voting methodologists. The panel was divided into seven subgroups, each addressing a predefined clinical practice domain relevant to patients admitted to the intensive care unit (ICU) with ABI, defined as acute traumatic brain or cerebrovascular injury. The panel conducted systematic searches and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) method was used to evaluate evidence and formulate questions. A modified Delphi process was implemented with four rounds of voting in which panellists were asked to respond to questions (rounds 1–3) and then recommendation statements (final round). Strong recommendation, weak recommendation, or no recommendation were defined when > 85%, 75–85%, and < 75% of panellists, respectively, agreed with a statement. Results: The GRADE rating was low, very low, or absent across domains. The consensus produced 36 statements (19 strong recommendations, 6 weak recommendations, 11 no recommendation) regarding airway management, non-invasive respiratory support, strategies for mechanical ventilation, rescue interventions for respiratory failure, ventilator liberation, and tracheostomy in brain-injured patients. Several knowledge gaps were identified to inform future research efforts. Conclusions: This consensus provides guidance for the care of patients admitted to the ICU with ABI. Evidence was generally insufficient or lacking, and research is needed to demonstrate the feasibility, safety, and efficacy of different management approaches. © 2020, Springer-Verlag GmbH Germany, part of Springer Nature.

Published
2020

21. Mechanical ventilation in patients with acute brain injury: recommendations of the European Society of Intensive Care Medicine consensus

Author

Robba, C, Poole, D, Mcnett, M, Asehnoune, K, Bösel, J, Bruder, N, Chieregato, A, Cinotti, R, Duranteau, J, Einav, S, Ercole, A, Ferguson, N, Guerin, C, Siempos, I, Kurtz, P, Juffermans, N, Mancebo, J, Mascia, L, Mccredie, V, Nin, N, Oddo, M, Pelosi, P, Rabinstein, A, Neto, A, Seder, D, Skrifvars, M, Suarez, J, Taccone, F, van der Jagt, M, Citerio, G, Stevens, R, Robba, Chiara, Poole, Daniele, McNett, Molly, Asehnoune, Karim, Bösel, Julian, Bruder, Nicolas, Chieregato, Arturo, Cinotti, Raphael, Duranteau, Jacques, Einav, Sharon, Ercole, Ari, Ferguson, Niall, Guerin, Claude, Siempos, Ilias I., Kurtz, Pedro, Juffermans, Nicole P., Mancebo, Jordi, Mascia, Luciana, McCredie, Victoria, Nin, Nicolas, Oddo, Mauro, Pelosi, Paolo, Rabinstein, Alejandro A., Neto, Ary Serpa, Seder, David B., Skrifvars, Markus B., Suarez, Jose I., Taccone, Fabio Silvio, van der Jagt, Mathieu, Citerio, Giuseppe, Stevens, Robert D., Robba, C, Poole, D, Mcnett, M, Asehnoune, K, Bösel, J, Bruder, N, Chieregato, A, Cinotti, R, Duranteau, J, Einav, S, Ercole, A, Ferguson, N, Guerin, C, Siempos, I, Kurtz, P, Juffermans, N, Mancebo, J, Mascia, L, Mccredie, V, Nin, N, Oddo, M, Pelosi, P, Rabinstein, A, Neto, A, Seder, D, Skrifvars, M, Suarez, J, Taccone, F, van der Jagt, M, Citerio, G, Stevens, R, Robba, Chiara, Poole, Daniele, McNett, Molly, Asehnoune, Karim, Bösel, Julian, Bruder, Nicolas, Chieregato, Arturo, Cinotti, Raphael, Duranteau, Jacques, Einav, Sharon, Ercole, Ari, Ferguson, Niall, Guerin, Claude, Siempos, Ilias I., Kurtz, Pedro, Juffermans, Nicole P., Mancebo, Jordi, Mascia, Luciana, McCredie, Victoria, Nin, Nicolas, Oddo, Mauro, Pelosi, Paolo, Rabinstein, Alejandro A., Neto, Ary Serpa, Seder, David B., Skrifvars, Markus B., Suarez, Jose I., Taccone, Fabio Silvio, van der Jagt, Mathieu, Citerio, Giuseppe, and Stevens, Robert D.

Abstract

Purpose: To provide clinical practice recommendations and generate a research agenda on mechanical ventilation and respiratory support in patients with acute brain injury (ABI). Methods: An international consensus panel was convened including 29 clinician-scientists in intensive care medicine with expertise in acute respiratory failure, neurointensive care, or both, and two non-voting methodologists. The panel was divided into seven subgroups, each addressing a predefined clinical practice domain relevant to patients admitted to the intensive care unit (ICU) with ABI, defined as acute traumatic brain or cerebrovascular injury. The panel conducted systematic searches and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) method was used to evaluate evidence and formulate questions. A modified Delphi process was implemented with four rounds of voting in which panellists were asked to respond to questions (rounds 1–3) and then recommendation statements (final round). Strong recommendation, weak recommendation, or no recommendation were defined when > 85%, 75–85%, and < 75% of panellists, respectively, agreed with a statement. Results: The GRADE rating was low, very low, or absent across domains. The consensus produced 36 statements (19 strong recommendations, 6 weak recommendations, 11 no recommendation) regarding airway management, non-invasive respiratory support, strategies for mechanical ventilation, rescue interventions for respiratory failure, ventilator liberation, and tracheostomy in brain-injured patients. Several knowledge gaps were identified to inform future research efforts. Conclusions: This consensus provides guidance for the care of patients admitted to the ICU with ABI. Evidence was generally insufficient or lacking, and research is needed to demonstrate the feasibility, safety, and efficacy of different management approaches.

Published
2020

34. A multicentre observational study on management of general anaesthesia in elderly patients at high-risk of postoperative adverse outcomes

Author

Molliex, Serge, primary, Passot, Sylvie, additional, Morel, Jerome, additional, Futier, Emmanuel, additional, Lefrant, Jean Yves, additional, Constantin, Jean Michel, additional, Le Manach, Yannick, additional, Pereira, Bruno, additional, Bruder, N., additional, Vaisse, C., additional, Bechis, C., additional, Bernard, L., additional, Leone, M., additional, Poirier, M., additional, Vincent, A., additional, Abdelkrim, N., additional, Paugam, C., additional, Lion, F., additional, Montravers, P., additional, Langeron, O., additional, Raux, M., additional, Baussier, M., additional, Xu, K., additional, Bart, F., additional, Dagois, S., additional, Plaud, B., additional, Rabuel, C., additional, Roland, E., additional, Biais, M., additional, Nouette-Gaulain, K., additional, Cabart, A., additional, Hanouz, J.L., additional, Lambert, C., additional, Godet, T., additional, Thibault, S., additional, Bouhemad, B., additional, Chambade, E., additional, Bouzat, P., additional, Garot, M., additional, Lebuffe, G., additional, Lallemant, F., additional, Lemery, C., additional, Tavernier, B., additional, de Jong, A., additional, Jaber, S., additional, Verzilli, D., additional, Delannoy, M., additional, Meistelman, C., additional, Carles, M., additional, Tran, L., additional, Bertran, S., additional, Cuvillon, P., additional, Ripart, J., additional, Simon-Pene, S., additional, Boisson, M., additional, Debaene, B., additional, Beloeil, H., additional, Godet, G., additional, Collange, O., additional, Mertes, P.M., additional, Diemunsch, P., additional, Joganah, D., additional, Oehlkern, L., additional, Baulieu, M., additional, Beauchesne, B., additional, Beraud, A.M., additional, Berthier-Berrada, S., additional, Bien, J.Y., additional, Dupont, G., additional, Gavory, J., additional, Lambert, P., additional, Lanoiselée, J., additional, Zufferey, P., additional, Ferré, F., additional, Martin, C., additional, Minville, V., additional, Planté, B., additional, Baffeleuf, B., additional, Ben Abdelkarim, M., additional, David, J.S., additional, Incagnoli, P., additional, Khaled, M., additional, Laplace, M.C., additional, Lefevre, M., additional, Piriou, V., additional, Aubrun, F., additional, Cero, V., additional, Delsuc, C., additional, Faulcon, C., additional, Meuret, P., additional, Rimmelé, T., additional, and Truc, C., additional

Published
2019
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37. Use of brain diffusion tensor imaging for the prediction of long-term neurological outcomes in patients after cardiac arrest: a multicentre, international, prospective, observational, cohort study

Author

Velly, L, Perlbarg, V, Boulier, T, Adam, N, Delphine, S, Luyt, C, Battisti, V, Torkomian, G, Arbelot, C, Chabanne, R, Jean, B, Di Perri, C, Laureys, S, Citerio, G, Vargiolu, A, Rohaut, B, Bruder, N, Girard, N, Silva, S, Cottenceau, V, Tourdias, T, Coulon, O, Riou, B, Naccache, L, Gupta, R, Benali, H, Galanaud, D, Puybasset, L, Constantin, J, Chastre, J, Amour, J, Vezinet, C, Rouby, J, Raux, M, Langeron, O, Degos, V, Bolgert, F, Weiss, N, Similowski, T, Demoule, A, Duguet, A, Tollard, E, Veber, B, Lotterie, J, Sanchez Pena, P, Génestal, M, Patassini, M, Luyt, CE, Constantin, JM, Rouby, JJ, Lotterie, JA, Velly, L, Perlbarg, V, Boulier, T, Adam, N, Delphine, S, Luyt, C, Battisti, V, Torkomian, G, Arbelot, C, Chabanne, R, Jean, B, Di Perri, C, Laureys, S, Citerio, G, Vargiolu, A, Rohaut, B, Bruder, N, Girard, N, Silva, S, Cottenceau, V, Tourdias, T, Coulon, O, Riou, B, Naccache, L, Gupta, R, Benali, H, Galanaud, D, Puybasset, L, Constantin, J, Chastre, J, Amour, J, Vezinet, C, Rouby, J, Raux, M, Langeron, O, Degos, V, Bolgert, F, Weiss, N, Similowski, T, Demoule, A, Duguet, A, Tollard, E, Veber, B, Lotterie, J, Sanchez Pena, P, Génestal, M, Patassini, M, Luyt, CE, Constantin, JM, Rouby, JJ, and Lotterie, JA

Abstract

Background: Prediction of neurological outcome after cardiac arrest is a major challenge. The aim of this study was to assess whether quantitative whole-brain white matter fractional anisotropy (WWM-FA) measured by diffusion tensor imaging between day 7 and day 28 after cardiac arrest can predict long-term neurological outcome. Methods: This prospective, observational, cohort study (part of the MRI-COMA study) was done in 14 centres in France, Italy, and Belgium. We enrolled patients aged 18 years or older who had been unconscious for at least 7 days after cardiac arrest into the derivation cohort. The following year, we recruited the validation cohort on the same basis. We also recruited a minimum of five healthy volunteers at each centre for the normalisation procedure. WWM-FA values were compared with standard criteria for unfavourable outcome, conventional MRI sequences (fluid-attenuated inversion recovery and diffusion-weighted imaging), and proton magnetic resonance spectroscopy. The primary outcome was the best achieved Glasgow-Pittsburgh Cerebral Performance Categories (CPC) at 6 months, dichotomised as favourable (CPC 1–2) and unfavourable outcome (CPC 3–5). Prognostication performance was assessed by the area under the receiver operating characteristic (ROC) curves and compared between groups. This study was registered with ClinicalTrials.gov, number NCT00577954. Findings: Between Oct 1, 2006, and June 30, 2014, 185 patients were enrolled in the derivation cohort, of whom 150 had an interpretable multimodal MRI and were included in the analysis. 33 (22%) patients had a favourable neurological outcome at 6 months. Prognostic accuracy, as quantified by the area under the ROC curve, was significantly higher with the normalised WWM-FA value (area under the ROC curve 0·95, 95% CI 0·91–0·98) than with the standard criteria for unfavourable outcome or other MRI sequences. In a subsequent validation cohort of 50 patients (enrolled between April 1, 2015, and March

Published
2018

44. Antifungal therapy for patients with proven or suspected Candida peritonitis: Amarcand2, a prospective cohort study in French intensive care units

Author

Montravers, P., primary, Perrigault, P.F., additional, Timsit, J.F., additional, Mira, J.P., additional, Lortholary, O., additional, Leroy, O., additional, Gangneux, J.P., additional, Guillemot, D., additional, Bensoussan, C., additional, Bailly, S., additional, Azoulay, E., additional, Constantin, J.M., additional, Dupont, H., additional, Aait Hssain, A., additional, Adda, M., additional, Allaouchiche, B., additional, Ammenouche, N., additional, Angel, G., additional, Argaud, L., additional, Badetti, C., additional, Baldesi, O., additional, Barthet, M.C., additional, Bastien, O., additional, Baudin, F., additional, Bellec, F., additional, Blasco, G., additional, Bollaert, P.E., additional, Bonadona, A., additional, Bretonniere, C., additional, Brocas, E., additional, Brua, S., additional, Bruder, N., additional, Brunin, G., additional, Cabaret, P., additional, Carpentier, D., additional, Cartier, J.C., additional, Cerf, C., additional, Chabanne, R., additional, Charles, P.E., additional, Cheval, C., additional, Cinotti, R., additional, Cohen, Y., additional, Cousson, J., additional, Delpierre, E., additional, Demory, D., additional, Diconne, E., additional, Du Cheyron, D., additional, Dubost, C., additional, Dumenil, A.S., additional, Durand, M., additional, Duroy, E., additional, Forel, J.M., additional, Foucher-Lezla, A.L., additional, Fratea, S., additional, Gally, J., additional, Gaudard, P., additional, Geffe, P., additional, Gergaud, S., additional, Gette, S., additional, Girault, C., additional, Goubaux, B., additional, Gouin, P., additional, Grenot, R., additional, Grossmith, G., additional, Guelon, D., additional, Guerin-Robardey, A.M., additional, Guervilly, C., additional, Hayl-Slayman, D., additional, Hilbert, G., additional, Houissa, H., additional, Hraiech, S., additional, Ichai, P., additional, Jung, B., additional, Kaidomar, M., additional, Karoubi, P., additional, Kherchache, A., additional, Lambiotte, F., additional, Lamhaut, L., additional, Launoy, A., additional, Lebreton, F., additional, Lefrant, J.Y., additional, Lemaire, C., additional, Lepape, A., additional, Lepoivre, T., additional, Lesieur, O., additional, Levy, B., additional, Luyt, C.E., additional, Mahe, P.J., additional, Mahul, P., additional, Mateu, P., additional, Megarbane, B., additional, Merle, J.C., additional, Montcriol, A., additional, Mootien, Y., additional, Navellou, J.C., additional, Ouattara, A., additional, Page, B., additional, Petitpas, F., additional, Plantefeve, G., additional, Quinart, A., additional, Quintard, H., additional, Ragonnet, B., additional, Roquilly, A., additional, Ruiz, J., additional, Saliba, F., additional, Samba, D., additional, Schmitt, Z., additional, Seguin, P., additional, Sejourne, C., additional, Tellier, A.C., additional, Thevenot, F., additional, Tonnelier, J.M., additional, Van Grunderbeek, N., additional, Vincent, J.F., additional, Wiramus, S., additional, and Zogheib, E., additional

Published
2017
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45. Venous thromboembolism prevention in surgery and obstetrics

Author

Samama, C. M., Albaladejo, P., Benhamou, D., Bertin-Maghit, M., Bruder, N., Doublet, J. D., Laversin, S., Leclerc, S., Marret, E., Mismetti, P., Samain, E., Steib, A., Renseigné, Non, Service d'anesthésie-réanimation [Hôtel-Dieu], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Hôtel-Dieu [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut de biologie et chimie des protéines [Lyon] (IBCP), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Département d'anesthésie-réanimation, Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), France Télécom Recherche & Développement (FT R&D), France Télécom, Institut Mondor de recherche biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Groupe de recherche sur la thrombose (GRT (EA 3065)), Université Jean Monnet [Saint-Étienne] (UJM), Hôpital Hôtel-Dieu [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Hôtel-Dieu [Paris], Institut de biologie et chimie des protéines [Lyon] ( IBCP ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique ( CNRS ), Assistance Publique - Hôpitaux de Marseille ( APHM ) - Hôpital de la Timone [CHU - APHM] ( TIMONE ), France Télécom Recherche & Développement ( FT R&D ), Institut Mondor de recherche biomédicale ( IMRB ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Paris-Est Créteil Val-de-Marne - Paris 12 ( UPEC UP12 ), Groupe de recherche sur la thrombose ( GRT (EA 3065) ), and Université Jean Monnet [Saint-Étienne] ( UJM )

Subjects
MESH: Pulmonary Embolism, medicine.medical_treatment, MESH: Pregnancy Complications, Hematologic, 030204 cardiovascular system & hematology, MESH : Anticoagulants, Postoperative Complications, MESH: Pregnancy, 0302 clinical medicine, Pregnancy, Risk Factors, MESH: Risk Factors, MESH: Postoperative Complications, MESH: Fibrinolytic Agents, MESH : Female, MESH: Heparin, Low-Molecular-Weight, MESH: Puerperal Disorders, Venous Thrombosis, Obstetrics, MESH : Venous Thrombosis, MESH : Risk Factors, 3. Good health, Pulmonary embolism, Venous thrombosis, 030220 oncology & carcinogenesis, MESH : Pulmonary Embolism, Ambulatory, Female, Neurosurgery, medicine.medical_specialty, MESH : Heparin, Low-Molecular-Weight, Compression stockings, MESH: Anticoagulants, 03 medical and health sciences, MESH : Pregnancy Complications, Hematologic, Fibrinolytic Agents, medicine, Humans, Intensive care medicine, MESH: Humans, business.industry, MESH : Humans, Pregnancy Complications, Hematologic, MESH : Puerperal Disorders, MESH : Fibrinolytic Agents, [ SDV.SP.PHARMA ] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, Anticoagulants, Puerperal Disorders, Heparin, Low-Molecular-Weight, Vascular surgery, medicine.disease, Surgery, MESH : Pregnancy, Critical appraisal, Anesthesiology and Pain Medicine, MESH: Venous Thrombosis, Orthopedic surgery, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, MESH : Postoperative Complications, Pulmonary Embolism, business, MESH: Female
Abstract

International audience; BACKGROUND AND OBJECTIVE: To produce up-to-date clinical practice guidelines on the prevention of venous thromboembolism in surgery and obstetrics. METHODS: A Steering Committee defined the scope of the topic, the questions to be answered, and the assessment criteria. Eight multidisciplinary working groups (total of 70 experts) performed a critical appraisal of the literature in the following disciplines: pharmacology of antithrombotic agents, orthopaedics; general surgery (gastrointestinal (GI) and varicose vein surgery); urology; gynaecology and obstetrics; thoracic, cardiac and vascular surgery; surgery of the head, neck and spine; and surgery of burns patients. The resultant reports and guidelines were submitted for comment and completion of the Appraisal of Guidelines Research & Evaluation questionnaire to a total of 150 peer reviewers, before producing definite guidelines. RESULTS: The report answers the following questions for each type of surgery: (i) What is the venous thromboembolism incidence according to clinical and/or paraclinical criteria in the absence of prophylaxis? (with stratification of venous thromboembolism risk into low, moderate and high categories); (ii) What is the efficacy and safety of the prophylactic measures used? (iii) When should prophylaxis be introduced and how long should it last? (iv) Does ambulatory surgery affect efficacy and safety of prophylaxis? CONCLUSIONS: Apart from answering the above questions, the guidelines provide a summary table for each discipline. This table stratifies types of surgery into the three risk categories, specifies the recommended prophylaxis for venous thromboembolism (pharmacological and/or mechanical) and grades each recommendation. In addition, whenever appropriate, the recommended prophylaxis is adjusted to low- and high-risk patients.

Published
2006

47. Hemodynamic changes during laryngoscopy: Does it matter?

Author

Bruder, N.

Subjects
Laparoscopy -- Health aspects, Hemodynamics -- Health aspects
Abstract

Byline: N. Bruder The article convincingly demonstrates in a large group of patients that, when tracheal intubation is not difficult, laryngoscopy is less stressful with the McCoy laryngoscope than with [...]

Published
2005

49. [Interest of EEG recording during direct electrical stimulation for brain mapping function in surgery]

Author

Trebuchon, A., Guye, Maxime, Tcherniack, V., Tramoni, E., Bruder, N., Metellus, P., Centre de résonance magnétique biologique et médicale (CRMBM), Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), and Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS)

Abstract

Trebuchon, A Guye, M Tcherniack, V Tramoni, E Bruder, N Metellus, P English Abstract France Annales francaises d'anesthesie et de reanimation Ann Fr Anesth Reanim. 2012 Jun;31(6):e87-90. Epub 2012 Jun 8.; Brain tumor surgery is at risk when lesions are located in eloquent areas. The interindividual anatomo-functional variability of the central nervous system implies that brain surgery within eloquent regions may induce neurological sequelae. Brain mapping using intraoperative direct electrical stimulation in awake patients has been for long validated as the standard for functional brain mapping. Direct electrical stimulation inducing a local transient electrical and functional disorganization is considered positive if the task performed by the patient is disturbed. The brain area stimulated is then considered as essential for the function tested. However, the exactitude of the information provided by this technique is cautious because the actual impact of cortical direct electrical stimulation is not known. Indeed, the possibility of false negative (insufficient intensity of the stimulation due to the heterogeneity of excitability threshold of different cortical areas) or false positive (current spread, interregional signal propagation responsible for remote effects, which make difficult the interpretation of positive or negative behavioural effects) constitute a limitation of this technique. To improve the sensitivity and specificity of this technique, we used an electrocorticographic recording system allowing a real time visualization of the local. We provide here evidence that direct cortical stimulation combined with electrocorticographic recording could be useful to detect remote after discharge and to adjust stimulation parameters. In addition this technique offers new perspective to better assess connectivity of cerebral networks.

Published
2012

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