17 results on '"Bruckmann, Anna"'
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2. Loiasis
- Author
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Bruckmann, Anna, Zierhut, Manfred, editor, Pavesio, Carlos, editor, Ohno, Shigeaki, editor, Orefice, Fernando, editor, and Rao, Narsing A., editor
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- 2016
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3. Assessment of retinopathy of prematurity regression and reactivation using an artificial intelligence–based vascular severity score
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Eilts, Sonja K., Pfeil, Johanna M., Poschkamp, Broder, Krohne, Tim U., Eter, Nicole, Barth, Teresa, Guthoff, Rainer, Lagrèze, Wolf, Grundel, Milena, Bründer, Marie-Christine, Busch, Martin, Kalpathy-Cramer, Jayashree, Chiang, Michael F., Chan, R. V. Paul, Coyner, Aaron S., Ostmo, Susan, Campbell, J. Peter, Stahl, Andreas, Pfeil, Johanna M, Bühler, Anima, Daniel, Moritz, Felzmann, Susanne, Gross, Nicolai, Horn, Stefanie, Lagrèze, Wolf A, Molnár, Fanni, Müller, Claudia, Reichl, Sabine, Reiff, Charlotte, Richter, Olga, Stech, Milena, Hentschel, Roland, Stavropolou, Dimitria, Tautz, Juliane, Bartsch, Kerstin, Braunstein, Jennifer, Brinken, Ralf, Brinkmann, Christian Karl, Czauderna, Joanna, Dralle, Wiebke, Gliem, Martin, Goebel, Arno, Heymer, Philipp, Hofmann, Martina, Holz, Frank G, Krohne, Tim U, Kupitz, David, Müller, Philipp, Petrak, Michael, Schmitz, Eva Janine, Schmitz-Valckenberg, Steffen, Schröder, Moritz, Steinberg, Julia, Supé, Julia, Kant, Evelyn, Kunze, Diana, Müller, Andreas, Adorf, Adeline, Alex, Anne, Alten, Florian, Clemens, Christoph R, Falkenau, Silvia, Friedhoff, Caroline, Loos, Desiree Sandra, Mihailovic, Natasa, Termühlen, Julia, Uhlig, Constantin, Hörnig-Franz, Isabell, Rieger-Fackeldey, Esther, Tekaat, Maria, Werner, Claudius, Altmann, Mathias, Blecha, Christiane, Brandl-Rühle, Sabine, Helbig, Horst, Hufendiek, Karsten, Jägle, Herbert, Konrad, Julia, Kopetzky, Eva, Lehmann, Fabian, Oberacher-Velten, Isabel, Keller-Wackerbauer, Annette, Kittel, Jochen, Segerer, Hugo, Ackermann, Phillip, Benga, Jemina, Guthoff, Tanja, Kleinert, Elena, Mayatepek, Ertan, Schrader, Stefan, Völker, Magdalena, Höhn, Thomas, Lohmeier, Klaus, Sabir, Hemmen, Brevis, Francisco, Mönig, Tina, Schwarz, Simone, Ehmer, Angela, Meltendorf, Synke, Schuart, Claudia, Avenarius, Stefan, Böttger, Ralf, Apel, Christoph, Bergmann, Anne, Herrmann, Karsten, Ockert-Schön, Franziska, Wegener, Sabine, Ehrt, Oliver, Nentwich, Martin, Pressler, Angelika, Rudolph, Günther, Genzel-Boroviczeny, Orsolya, Schmidt, Susanne, Münch, Hans-Georg, Thilmany, Claude, Aisenbrey, Sabine, Bruckmann, Anna, Dimopoulos, Spyridon, Hagemann, Ulrike, Inhoffen, Werner, Partsch, Michael, Schrader, Merle, Süsskind, Daniela, Völker, Michael, Bialkowski, Anja, Müller-Hansen, Ingo, Gerberth, Andrea, Hasselbach, Heike Christine, Lindemann, Solveig, Purtskhvanidze, Konstantine, Raffel, Yvonne, Roider, Johann, Schröder, Greta, Szymanek, Beke, Tode, Jan, Bendiks, Meike, Modlich, Simon, Jandeck, Isabel, Gerding, Heinrich, Smith, Lois E H, Eilts, Sonja K., Pfeil, Johanna M., Poschkamp, Broder, Krohne, Tim U., Eter, Nicole, Barth, Teresa, Guthoff, Rainer, Lagrèze, Wolf, Grundel, Milena, Bründer, Marie-Christine, Busch, Martin, Kalpathy-Cramer, Jayashree, Chiang, Michael F., Chan, R. V. Paul, Coyner, Aaron S., Ostmo, Susan, Campbell, J. Peter, Stahl, Andreas, Pfeil, Johanna M, Bühler, Anima, Daniel, Moritz, Felzmann, Susanne, Gross, Nicolai, Horn, Stefanie, Lagrèze, Wolf A, Molnár, Fanni, Müller, Claudia, Reichl, Sabine, Reiff, Charlotte, Richter, Olga, Stech, Milena, Hentschel, Roland, Stavropolou, Dimitria, Tautz, Juliane, Bartsch, Kerstin, Braunstein, Jennifer, Brinken, Ralf, Brinkmann, Christian Karl, Czauderna, Joanna, Dralle, Wiebke, Gliem, Martin, Goebel, Arno, Heymer, Philipp, Hofmann, Martina, Holz, Frank G, Krohne, Tim U, Kupitz, David, Müller, Philipp, Petrak, Michael, Schmitz, Eva Janine, Schmitz-Valckenberg, Steffen, Schröder, Moritz, Steinberg, Julia, Supé, Julia, Kant, Evelyn, Kunze, Diana, Müller, Andreas, Adorf, Adeline, Alex, Anne, Alten, Florian, Clemens, Christoph R, Falkenau, Silvia, Friedhoff, Caroline, Loos, Desiree Sandra, Mihailovic, Natasa, Termühlen, Julia, Uhlig, Constantin, Hörnig-Franz, Isabell, Rieger-Fackeldey, Esther, Tekaat, Maria, Werner, Claudius, Altmann, Mathias, Blecha, Christiane, Brandl-Rühle, Sabine, Helbig, Horst, Hufendiek, Karsten, Jägle, Herbert, Konrad, Julia, Kopetzky, Eva, Lehmann, Fabian, Oberacher-Velten, Isabel, Keller-Wackerbauer, Annette, Kittel, Jochen, Segerer, Hugo, Ackermann, Phillip, Benga, Jemina, Guthoff, Tanja, Kleinert, Elena, Mayatepek, Ertan, Schrader, Stefan, Völker, Magdalena, Höhn, Thomas, Lohmeier, Klaus, Sabir, Hemmen, Brevis, Francisco, Mönig, Tina, Schwarz, Simone, Ehmer, Angela, Meltendorf, Synke, Schuart, Claudia, Avenarius, Stefan, Böttger, Ralf, Apel, Christoph, Bergmann, Anne, Herrmann, Karsten, Ockert-Schön, Franziska, Wegener, Sabine, Ehrt, Oliver, Nentwich, Martin, Pressler, Angelika, Rudolph, Günther, Genzel-Boroviczeny, Orsolya, Schmidt, Susanne, Münch, Hans-Georg, Thilmany, Claude, Aisenbrey, Sabine, Bruckmann, Anna, Dimopoulos, Spyridon, Hagemann, Ulrike, Inhoffen, Werner, Partsch, Michael, Schrader, Merle, Süsskind, Daniela, Völker, Michael, Bialkowski, Anja, Müller-Hansen, Ingo, Gerberth, Andrea, Hasselbach, Heike Christine, Lindemann, Solveig, Purtskhvanidze, Konstantine, Raffel, Yvonne, Roider, Johann, Schröder, Greta, Szymanek, Beke, Tode, Jan, Bendiks, Meike, Modlich, Simon, Jandeck, Isabel, Gerding, Heinrich, and Smith, Lois E H
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- 2023
4. Population receptive field analysis of the primary visual cortex complements perimetry in patients with homonymous visual field defects
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Papanikolaou, Amalia, Keliris, Georgios A., Papageorgiou, T. Dorina, Shao, Yibin, Krapp, Elke, Papageorgiou, Eleni, Stingl, Katarina, Bruckmann, Anna, Schiefer, Ulrich, Logothetis, Nikos K., and Smirnakis, Stelios M.
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- 2014
5. Artificial vision with wirelessly powered subretinal electronic implant alpha-IMS
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Stingl, Katarina, Bartz-Schmidt, Karl Ulrich, Besch, Dorothea, Braun, Angelika, Bruckmann, Anna, Gekeler, Florian, Greppmaier, Udo, Hipp, Stephanie, Hörtdörfer, Gernot, Kernstock, Christoph, Koitschev, Assen, Kusnyerik, Akos, Sachs, Helmut, Schatz, Andreas, Stingl, Krunoslav T., Peters, Tobias, Wilhelm, Barbara, and Zrenner, Eberhart
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- 2013
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6. Peripheral refraction in pseudophakic eyes measured by infrared scanning photoretinoscopy
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Tabernero, Juan, Ohlendorf, Arne, Fischer, M. Dominik, Bruckmann, Anna R., Schiefer, Ulrich, and Schaeffel, Frank
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- 2012
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7. Subretinal electronic chips allow blind patients to read letters and combine them to words
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Zrenner, Eberhart, Bartz-Schmidt, Karl Ulrich, Benav, Heval, Besch, Dorothea, Bruckmann, Anna, Gabel, Veit-Peter, Gekeler, Florian, Greppmaier, Udo, Harscher, Alex, Kibbel, Steffen, Koch, Johannes, Kusnyerik, Akos, Peters, Tobias, Stingl, Katarina, Sachs, Helmut, Stett, Alfred, Szurman, Peter, Wilhelm, Barbara, and Wilke, Robert
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- 2011
8. Associating the magnitude of relative afferent pupillary defect (RAPD) with visual field indices in glaucoma patients
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Schiefer, Ulrich, Dietzsch, Janko, Dietz, Klaus, Wilhelm, Bärbel, Bruckmann, Anna, Wilhelm, Helmut, Kitiratschky, Veronique, and Januschowski, Kai
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- 2012
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9. Comparison of advanced visual field defects measured with the Tübingen Mobile Campimeter and the Octopus 101 perimeter
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Bruckmann, Anna, Volpe, Nicholas J., Paetzold, Jens, Vonthein, Reinhard, and Schiefer, Ulrich
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- 2010
10. Comparing alternative ranibizumab dosages for safety and efficacy in retinopathy of prematurity : a randomized clinical trial
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Stahl, Andreas, Krohne, Tim U., Eter, Nicole, Oberacher-Velten, Isabel, Guthoff, Rainer, Meltendorf, Synke, Ehrt, Oliver, Aisenbrey, Sabine, Roider, Johann, Gerding, Heinrich, Jandeck, Claudia, Smith, Lois E. H., Walz, Johanna M., Bühler, Anima, Daniel, Moritz, Felzmann, Susanne, Gross, Nicolai, Horn, Stefanie, Lagrèze, Wolf, Molnár, Fanni, Müller, Claudia, Reichl, Sabine, Reiff, Charlotte, Richter, Olga, Stech, Milena, Hentschel, Roland, Stavropolou, Dimitria, Tautz, Juliane, Bartsch, Kerstin, Braunstein, Jennifer, Brinken, Ralf, Brinkmann, Christian Karl, Czauderna, Joanna, Dralle, Wiebke, Gliem, Martin, Goebel, Arno, Heymer, Philipp, Hofmann, Martina, Holz, Frank G., Kupitz, David, Müller, Philipp, Petrak, Michael, Schmitz, Eva Janine, Schmitz-Valckenberg, Steffen, Schröder, Moritz, Steinberg, Julia, Supé, Julia, Kant, Evelyn, Kunze, Diana, Müller, Andreas, Adorf, Adeline, Alex, Anne, Alten, Florian, Clemens, Christoph R., Falkenau, Silvia, Friedhoff, Caroline, Loos, Desiree Sandra, Mihailovic, Natasa, Termühlen, Julia, Uhlig, Constantin, Hörnig-Franz, Isabell, Rieger-Fackeldey, Esther, Tekaat, Maria, Werner, Claudius, Altmann, Mathias, Barth, Theresa, Blecha, Christiane, Brandl-Rühle, Sabine, Helbig, Horst, Hufendiek, Karsten, Jägle, Herbert, Konrad, Julia, Kopetzky, Eva, Lehmann, Fabian, Keller-Wackerbauer, Annette, Kittel, Jochen, Segerer, Hugo, Ackermann, Phillip, Benga, Jemina, Guthoff, Tanja, Kleinert, Elena, Mayatepek, Ertan, Schrader, Stefan, Völker, Magdalena, Höhn, Thomas, Lohmeier, Klaus, Sabir, Hemmen, Brevis, Francisco, Mönig, Tina, Schwarz, Simone, Ehmer, Angela, Schuart, Claudia, Avenarius, Stefan, Böttger, Ralf, Apel, Christoph, Bergmann, Anne, Herrmann, Karsten, Ockert-Schön, Franziska, Wegener, Sabine, Nentwich, Martin, Pressler, Angelika, Rudolph, Günther, Genzel-Boroviczeny, Orsolya, Schmidt, Susanne, Münch, Hans-Georg, Thilmany, Claude, Bruckmann, Anna, Dimopoulos, Spyridon, Hagemann, Ulrike, Inhoffen, Werner, Partsch, Michael, Schrader, Merle, Süsskind, Daniela, Völker, Michael, Bialkowski, Anja, Müller-Hansen, Ingo, Gerberth, Andrea, Hasselbach, Heike Christine, Lindemann, Solveig, Purtskhvanidze, Konstantine, Raffel, Yvonne, Schröder, Greta, Szymanek, Beke, Tode, Jan, Bendiks, Meike, and Modlich, Simon
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Male ,Vascular Endothelial Growth Factor A ,medicine.medical_specialty ,genetic structures ,Bevacizumab ,Medizin ,Angiogenesis Inhibitors ,Pilot Projects ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Double-Blind Method ,Randomized controlled trial ,law ,Germany ,Ranibizumab ,Internal medicine ,Clinical endpoint ,Humans ,Medicine ,Retinopathy of Prematurity ,Dosing ,Original Investigation ,Dose-Response Relationship, Drug ,business.industry ,Standard treatment ,Infant, Newborn ,Retinopathy of prematurity ,Odds ratio ,medicine.disease ,Treatment Outcome ,Pediatrics, Perinatology and Child Health ,030221 ophthalmology & optometry ,Female ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Importance Anti–vascular endothelial growth factor (VEGF) therapies are a novel treatment option in retinopathy of prematurity (ROP). Data on dosing, efficacy, and safety are insufficient. Objective To investigate lower doses of anti-VEGF therapy with ranibizumab, a substance with a significantly shorter systemic half-life than the standard treatment, bevacizumab. Design, Setting, and Participants This randomized, multicenter, double-blind, investigator-initiated trial at 9 academic medical centers in Germany compared ranibizumab doses of 0.12 mg vs 0.20 mg in infants with bilateral aggressive posterior ROP; ROP stage 1 with plus disease, 2 with plus disease, or 3 with or without plus disease in zone I; or ROP stage 3 with plus disease in posterior zone II. Patients were recruited between September 2014 and August 2016. Twenty infants were screened and 19 were randomized. Interventions All infants received 1 baseline ranibizumab injection per eye. Reinjections were allowed in case of ROP recurrence after at least 28 days. Main Outcomes and Measures The primary end point was the number of infants who did not require rescue therapy at 24 weeks. Key secondary end points included time-to-event analyses, progression of physiologic vascularization, and plasma VEGF levels. Stages of ROP were photodocumented and reviewed by an expert committee. Results Nineteen infants with ROP were enrolled (9 [47.4%] female; median [range] postmenstrual age at first treatment, 36.4 [34.7-39.7] weeks), 3 of whom died during the study (1 in the 0.12-mg group and 2 in the 0.20-mg group). Of the surviving infants, 8 (88.9%) (17 eyes [94.4%]) in the 0.12-mg group and 6 (85.7%) (13 eyes [92.9%]) in the 0.20-mg group did not require rescue therapy. Both ranibizumab doses were equally successful in controlling acute ROP (Cochran-Mantel-Haenszel analysis; odds ratio, 1.88; 95% CI, 0.26-13.49;P = .53). Physiologic intraretinal vascularization was superior in the 0.12-mg group. The VEGF plasma levels were not systematically altered in either group. Conclusions and Relevance This pilot study demonstrates that ranibizumab is effective in controlling acute ROP and that 24% of the standard adult dose (0.12 mg) appears equally effective as 40% (0.20 mg). Superior vascularization of the peripheral retina with 0.12 mg of ranibizumab indicates that the lower dose may be favorable. Unchanged plasma VEGF levels point toward a limited systemic drug exposure after ranibizumab. Trial Registration clinicaltrials.gov Identifier:NCT02134457and clinicaltrialsregister.eu Identifier:2013-002539-13.
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- 2018
11. Comparison of advanced visual field defects, measured with the Tuebingen Mobile Campimeter (TMC) and the Octopus 101 perimeter
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Bruckmann, Anna and Schiefer, Ulrich (Prof. Dr. med)
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Gesichtsfeld , Kampimetrie ,Visual field , screening method , perimetry , campimetry , portable ,Gesichtsfeld , Perimetrie , Kampimetrie , tragbar , Screening Methode - Abstract
Ziel dieser Studie war, die Gesichtsfeld-Untersuchungsergebnisse von zwei verschiedenen Perimetern an Patienten mit fortgeschrittenen Gesichtsfeldausfällen zu vergleichen. Dazu wurde ein Standardgerät, das Octopus 101 (Haag-Streit) und das zu testende, in der Augen-klinik neu entwickelte tragbare Gerät, das Tübingen Mobilcampimeter (TMC) verwendet. Methoden: 31 Patienten im Alter zwischen 18 und 75 Jahren mit fortgeschrittenen Gesichtsfeldausfällen (fortgeschrittene Bogenskotome, konzentrische Einengung, Gesichtsfelddefekte, die die Mittellinie respektieren) und 6 gesunde Probanden wurden in die Studie eingeschlossen. Die erste Untersuchung fand immer am Referenzinstrument Octopus 101 statt: 30° NO Raster mit 192 Stimuli, 10 cd/m² Hintergrundleuchtdichte, Stimulusgröße Goldmann III = 26' und 320 cd/m² maximaler Stimulusleuchtdichte. Die zweite Untersuchung am TMC erfolgte innerhalb der nächsten drei Stunden und verblindet hinsichtlich der Referenzdiagnose mit 84 präsentierten Stimuli als Teil des Octopus 101 Rasters, Hintergrundleuchtdichte zwischen 8 und 20 cd/m², Stimulusgröße 34’ und Stimulusleuchtdichte 320 bis 370 cd/m². Die Genauigkeit (Anteil der an beiden Geräten konkordant wahrgenommenen und konkordant nicht wahrgenommenen Gesichtsfeldorte), die Sensitivität und die Spezifität wurden pro Person ausgezählt und ihre Mediane über die durchschnittlichen Logits berechnet. Ebenso in ein 95%-Konfidenzintervall (KI) geschätzt wurde das geometrische Mittel des Verhältnisses der Untersuchungszeiten. Ergebnisse: Da alle Gesichtsfelder mit dem TMC den gleichen Defektklassen zugeordnet wurden, betragen die Untergrenzen von KI für die Genauigkeit 91 %, die Sensitivität 89 % und die Spezifität 54 % der Personen. Bezüglich der gesamten Stichprobe war der Anteil der am TMC aber nicht am Octopus 101 wahrgenommenen Punkte von allen diskordant wahrgenommenen Punkten 35 % (KI: 30 % bis 40 %). Im Hinblick auf die einzelnen Gesichtsfelddefekte war die mediane punktweise Genauigkeit am größten bei den gesunden Probanden (97,9 %; KI: 97 bis 98.5 %), und am geringsten bei Patienten mit Bogenskotomen (80,6 %; KI: 77,3 % bis 83,5 %). Die mediane punktweise Sensitivität war am höchsten bei Patienten mit konzentrischer Einengung (94.5 %; KI: 82,9 bis 98,4 %), am niedrigsten bei gesunden Probanden (59,1 %; KI: 26,3 bis 85,3 %). Die mediane punktweise Spezifität lag am höchsten bei gesunden Probanden (98,1 %; KI: 96,6 bis 98,9 %), am niedrigsten bei Patienten mit konzentrischer Einengung (77,4 %; KI: 62,1 bis 87,7 %). Die durchschnittliche Untersuchungszeit lag bei 4,6 min am TMC und bei 9,8 min am Octopus 101. Zusammenfassung: Die Ergebnisse zeigen, dass das TMC ein geeignetes Gerät ist, um Gesichtsfeldausfälle sicher aufzudecken und zu dokumentieren. Purpose: To compare the results of the visual field testing of advanced visual field defects (VFDs) measured with a conventional perimeter (Octopus 101; O-101) and a new portable testing device, the Tuebingen Mobile Campimeter (TMC). Methods: Thirty seven subjects (18 to 75 years old), 13 with advanced arcuate scotomas, 12 with VFD respecting the vertical meridians, 6 with concentric constriction and 6 healthy individuals were included. Subjects were first tested with the Octopus 101 as reference instrument, 30°-NO grid, 192 stimuli, 10 cd/m² background luminance, stimulus Goldmann size III = 26’ and 320 cd/m² stimulus luminance. This was followed by testing with the TMC the same day with 84 stimuli as a subset of the O-101 grid, stimulus size 34', luminance 320 to 370 cd/m², background luminance 8 to 20 cd/m². Pointwise accuracy (proportion of concordant locations), sensitivity and specificity were estimated into 95% confidence intervals (CI) by averaging individual logits. Both examination durations were compared. Results: The TMC results are highly concordant with the results assessed with the Octopus 101 for all four defect classes. All 37 patterns were correctly recognized by the TMC examiner, so that lower limits of CI were for accuracy 91 %, sensitivity 89 % and specificity 54 %. For the entire sample, the percentage of discordant points, perceived with the TMC but not with the O-101, among all discordant points was 35 % (CI: 30 % to 40 %). Analysed by VFD pattern, the average pointwise accuracy was highest in healthy (97.9 %; CI: 97 % to 98.5 %), and lowest in arcuate scotomas (80.6 %; CI: 77.3 % to 83.5 %). Average pointwise sensitivity was highest in concentric constriction (94.5 %; CI: 82.9 % to 98.4 %), lowest in healthy individuals (59.1 %; CI: 26.3 % to 85.3 %). Average pointwise specificity was highest in healthy (98.1 %; CI: 96.6 % to 98.9 %), lowest in concentric constriction (77.4 %; CI: 62.1 % to 87.7 %). Mean patient examination time was 4.6 min with the TMC and 9.8 min with the Octopus 101. Conclusion: The results indicate that the TMC is a feasible device for documented detection of visual field loss. Key words: Visual field – screening method – perimetry – campimetry – portable – concentric – grid
- Published
- 2007
12. Safety and efficacy of subretinal visual implants in humans: methodological aspects
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Stingl, Katarina, primary, Bach, Michael, additional, Bartz‐schmidt, Karl‐ulrich, additional, Braun, Angelika, additional, Bruckmann, Anna, additional, Gekeler, Florian, additional, Greppmaier, Udo, additional, Hörtdörfer, Gernot, additional, Kusnyerik, Akos, additional, Peters, Tobias, additional, Wilhelm, Barbara, additional, Wilke, Robert, additional, and Zrenner, Eberhart, additional
- Published
- 2013
- Full Text
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13. Positioning of Electronic Subretinal Implants in Blind Retinitis Pigmentosa Patients Through Multimodal Assessment of Retinal Structures
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Kusnyerik, Akos, primary, Greppmaier, Udo, additional, Wilke, Robert, additional, Gekeler, Florian, additional, Wilhelm, Barbara, additional, Sachs, Helmut G., additional, Bartz-Schmidt, Karl Ulrich, additional, Klose, Uwe, additional, Stingl, Katarina, additional, Resch, Miklos D., additional, Hekmat, Anusch, additional, Bruckmann, Anna, additional, Karacs, Kristof, additional, Nemeth, Janos, additional, Suveges, Ildiko, additional, and Zrenner, Eberhart, additional
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- 2012
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14. Spatial Resolution and Perception of Patterns Mediated by a Subretinal 16-Electrode Array in Patients Blinded by Hereditary Retinal Dystrophies
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Wilke, Robert, primary, Gabel, Veit-Peter, additional, Sachs, Helmut, additional, Bartz Schmidt, Karl-Ulrich, additional, Gekeler, Florian, additional, Besch, Dorothea, additional, Szurman, Peter, additional, Stett, Alfred, additional, Wilhelm, Barbara, additional, Peters, Tobias, additional, Harscher, Alex, additional, Greppmaier, Udo, additional, Kibbel, Steffen, additional, Benav, Heval, additional, Bruckmann, Anna, additional, Stingl, Katarina, additional, Kusnyerik, Akos, additional, and Zrenner, Eberhart, additional
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- 2011
- Full Text
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15. Peripheral Refraction Profiles in Subjects with Low Foveal Refractive Errors
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Tabernero, Juan, primary, Ohlendorf, Arne, additional, Fischer, M. Dominik, additional, Bruckmann, Anna R., additional, Schiefer, Ulrich, additional, and Schaeffel, Frank, additional
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- 2011
- Full Text
- View/download PDF
16. Subretinal electronic chips allow blind patients to read letters and combine them to words
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Zrenner, Eberhart, primary, Bartz-Schmidt, Karl Ulrich, additional, Benav, Heval, additional, Besch, Dorothea, additional, Bruckmann, Anna, additional, Gabel, Veit-Peter, additional, Gekeler, Florian, additional, Greppmaier, Udo, additional, Harscher, Alex, additional, Kibbel, Steffen, additional, Koch, Johannes, additional, Kusnyerik, Akos, additional, Peters, Tobias, additional, Stingl, Katarina, additional, Sachs, Helmut, additional, Stett, Alfred, additional, Szurman, Peter, additional, Wilhelm, Barbara, additional, and Wilke, Robert, additional
- Published
- 2010
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17. Restoration of useful vision up to letter recognition capabilities using subretinal microphotodiodes.
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Benav H, Bartz-Schmidt KU, Besch D, Bruckmann A, Gekeler F, Greppmaier U, Harscher A, Kibbel S, Kusnyerik A, Peters T, Sachs H, Stett A, Stingl K, Wilhelm B, Wilke R, Wrobel W, and Zrenner E
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- Humans, Microelectrodes, Ophthalmoscopes, Photic Stimulation, Prosthesis Implantation, Electrodes, Implanted, Pattern Recognition, Visual physiology, Recovery of Function physiology, Retina physiopathology, Vision, Ocular physiology
- Abstract
Our group has developed a subretinal microphotodiode array for restoration of vision. In a clinical pilot study the array has been implanted in 11 patients suffering from photoreceptor degenerations. Here we present promising results from some of those patients where the retinal tissue above the chip was functional and the implant fulfilled its expected function. A spatial resolution of approximately 0.3 cycles/degree could be achieved with fine stripe patterns. In one subject where the implant had been placed directly under the macular region of the retina a visual acuity of 20/1000 could be measured. Artificially restored visual acuity of this quality has not been reported previously. Finally, we present images illustrating an approximation of how the visual perceptions might have appeared to the subjects, based on a mathematical model and patient reports.
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- 2010
- Full Text
- View/download PDF
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