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2. Allostatic load measures in older adults with subjective cognitive decline and mild cognitive impairment: A cross-sectional analysis from the Brazilian Memory and Aging Study

Author

Barbosa, Breno José Alencar Pires, Souza-Talarico, Juliana Nery de, Jesus, Maria Clara Ferreira de, Mota, Gabriel Paz Souza, Oliveira, Maira Okada de, Cassimiro, Luciana, Avolio, Isabella Maria Bello, Trés, Eduardo Sturzeneker, Borges, Conrado Regis, Teixeira, Thiago Bezerra Moraes, and Brucki, Sonia Maria Dozzi

Published
2024
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4. Dementia in Latin America: Paving the way toward a regional action plan.

Author

Parra, Mario Alfredo, Baez, Sandra, Sedeño, Lucas, Gonzalez Campo, Cecilia, Santamaría-García, Hernando, Aprahamian, Ivan, Bertolucci, Paulo Hf, Bustin, Julian, Camargos Bicalho, Maria Aparecida, Cano-Gutierrez, Carlos, Caramelli, Paulo, Chaves, Marcia LF, Cogram, Patricia, Beber, Bárbara Costa, Court, Felipe A, de Souza, Leonardo Cruz, Custodio, Nilton, Damian, Andres, de la Cruz, Myriam, Diehl Rodriguez, Roberta, Brucki, Sonia Maria Dozzi, Fajersztajn, Lais, Farías, Gonzalo A, De Felice, Fernanda G, Ferrari, Raffaele, de Oliveira, Fabricio Ferreira, Ferreira, Sergio T, Ferretti, Ceres, Figueredo Balthazar, Marcio Luiz, Ferreira Frota, Norberto Anizio, Fuentes, Patricio, García, Adolfo M, Garcia, Patricia J, de Gobbi Porto, Fábio Henrique, Duque Peñailillo, Lissette, Engler, Henry Willy, Maier, Irene, Mata, Ignacio F, Gonzalez-Billault, Christian, Lopez, Oscar L, Morelli, Laura, Nitrini, Ricardo, Quiroz, Yakeel T, Guerrero Barragan, Alejandra, Huepe, David, Pio, Fabricio Joao, Suemoto, Claudia Kimie, Kochhann, Renata, Kochen, Silvia, Kumfor, Fiona, Lanata, Serggio, Miller, Bruce, Mansur, Leticia Lessa, Hosogi, Mirna Lie, Lillo, Patricia, Llibre Guerra, Jorge, Lira, David, Lopera, Francisco, Comas, Adelina, Avila-Funes, José Alberto, Sosa, Ana Luisa, Ramos, Claudia, Resende, Elisa de Paula França, Snyder, Heather M, Tarnanas, Ioannis, Yokoyama, Jenifer, Llibre, Juan, Cardona, Juan Felipe, Possin, Kate, Kosik, Kenneth S, Montesinos, Rosa, Moguilner, Sebastian, Solis, Patricia Cristina Lourdes, Ferretti-Rebustini, Renata Eloah de Lucena, Ramirez, Jeronimo Martin, Matallana, Diana, Mbakile-Mahlanza, Lingani, Marques Ton, Alyne Mendonça, Tavares, Ronnielly Melo, Miotto, Eliane C, Muniz-Terrera, Graciela, Muñoz-Nevárez, Luis Arnoldo, Orozco, David, Okada de Oliveira, Maira, Piguet, Olivier, Pintado Caipa, Maritza, Piña Escudero, Stefanie Danielle, Schilling, Lucas Porcello, Rodrigues Palmeira, André Luiz, Yassuda, Mônica Sanches, Santacruz-Escudero, Jose Manuel, Serafim, Rodrigo Bernardo, Smid, Jerusa, Slachevsky, Andrea, Serrano, Cecilia, Soto-Añari, Marcio, Takada, Leonel Tadao, Grinberg, Lea Tenenholz, Teixeira, Antonio Lucio, and Barbosa, Maira Tonidandel

Subjects
Latin America, biomarkers, clinical trials, dementia, epidemiology, evidence-based recommendations, genetics, knowledge to action framework, networking and translational research, nonpharmacological interventions, Dementia, Clinical Research, Brain Disorders, Aging, Acquired Cognitive Impairment, Prevention, Neurological, Clinical Sciences, Neurosciences, Geriatrics
Abstract

Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, and socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, the Latin American and Caribbean Consortium on Dementia (LAC-CD) proposes an agenda for integration to deliver a Knowledge to Action Framework (KtAF). First, we summarize evidence-based strategies (epidemiology, genetics, biomarkers, clinical trials, nonpharmacological interventions, networking, and translational research) and align them to current global strategies to translate regional knowledge into transformative actions. Then we characterize key sources of complexity (genetic isolates, admixture in populations, environmental factors, and barriers to effective interventions), map them to the above challenges, and provide the basic mosaics of knowledge toward a KtAF. Finally, we describe strategies supporting the knowledge creation stage that underpins the translational impact of KtAF.

Published
2021

6. Discovery and validation of dominantly inherited Alzheimer’s disease mutations in populations from Latin America

Author

Takada, Leonel Tadao, Aláez-Verson, Carmen, Burgute, Bhagyashri D., Nitrini, Ricardo, Sosa, Ana Luisa, Castilhos, Raphael Machado, Chaves, Marcia Fagundes, Longoria, Erika-Mariana, Carrillo-Sánchez, Karol, Brucki, Sonia Maria Dozzi, Flores-Lagunes, Luis Leonardo, Molina, Carolina, Olivares, Marcos Jimenez, Ziegemeier, Ellen, Petranek, Jennifer, Goate, Alison M., Cruchaga, Carlos, Renton, Alan E., Fernández, Maria Victoria, Day, Gregory S., McDade, Eric, Bateman, Randall J., Karch, Celeste M., and Llibre-Guerra, Jorge J.

Published
2022
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8. Deficits in short-term memory binding are detectable in individuals with brain amyloid deposition in the absence of overt neurodegeneration in the Alzheimer’s disease continuum

Author

Cecchini, Mario Amore, Yassuda, Mônica Sanches, Squarzoni, Paula, Coutinho, Artur Martins, de Paula Faria, Daniele, Duran, Fábio Luiz de Souza, Costa, Naomi Antunes da, Porto, Fábio Henrique de Gobbi, Nitrini, Ricardo, Forlenza, Orestes Vicente, Brucki, Sonia Maria Dozzi, Buchpiguel, Carlos Alberto, Parra, Mario A., and Busatto, Geraldo F.

Published
2021
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10. The impact of COVID-19 on the well-being and cognition of older adults living in the United States and Latin America

Author

Babulal, Ganesh M., Torres, Valeria L., Acosta, Daisy, Agüero, Cinthya, Aguilar-Navarro, Sara, Amariglio, Rebecca, Ussui, Juliana Aya, Baena, Ana, Bocanegra, Yamile, Brucki, Sonia Maria Dozzi, Bustin, Julian, Cabrera, Diego M., Custodio, Nilton, Diaz, Monica M., Peñailillo, Lissette Duque, Franco, Idalid, Gatchel, Jennifer R., Garza-Naveda, Ana Paola, González Lara, Mariana, Gutiérrez-Gutiérrez, Lidia, Guzmán-Vélez, Edmarie, Hanseeuw, Bernard J., Jimenez-Velazquez, Ivonne Z., Rodríguez, Tomás León, Llibre-Guerra, Jorge, Marquine, María J., Martinez, Jairo, Medina, Luis D., Miranda-Castillo, Claudia, Morlett Paredes, Alejandra, Munera, Diana, Nuñez-Herrera, Alberto, de Oliveira, Maira Okada, Palmer-Cancel, Santiago J., Pardilla-Delgado, Enmanuelle, Perales-Puchalt, Jaime, Pluim, Celina, Ramirez-Gomez, Liliana, Rentz, Dorene M., Rivera-Fernández, Claudia, Rosselli, Monica, Serrano, Cecilia M, Suing-Ortega, Maria Jose, Slachevsky, Andrea, Soto-Añari, Marcio, Sperling, Reisa A., Torrente, Fernando, Thumala, Daniela, Vannini, Patrizia, Vila-Castelar, Clara, Yañez-Escalante, Tatiana, and Quiroz, Yakeel T.

Published
2021
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14. Probable 4‐Repeat Tauopathy Criteria Predict Brain Amyloid Negativity, Distinct Clinical Features, and FDG‐PET/MRI Neurodegeneneration Patterns in Corticobasal Syndrome

Author

Parmera, Jacy Bezerra, primary, de Godoi Carneiro, Camila, additional, de Almeida, Isabel Junqueira, additional, de Oliveira, Marcos Castello Barbosa, additional, Barbosa, Pedro Melo, additional, Studart‐Neto, Adalberto, additional, Ono, Carla Rachel, additional, Nitrini, Ricardo, additional, Buchpiguel, Carlos Alberto, additional, Barbosa, Egberto Reis, additional, Brucki, Sonia Maria Dozzi, additional, and Coutinho, Artur Martins, additional

Published
2023
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15. Allostatic load measures in elderly subjects with mild cognitive impairment and subjective cognitive decline: a cross‐sectional analysis from the Brazilian Memory and Aging Study

Author

Barbosa, Breno José Alencar Pires, primary, Jesus, Maria Clara Ferreira, additional, de Oliveira, Maira Okada, additional, Cassimiro, Luciana, additional, Avolio, Isabella B, additional, Trés, Eduardo Sturzeneker, additional, Borges, Conrado Regis, additional, Teixeira, Thiago Bezerra Moraes, additional, Souza‐Talarico, Juliana Nery, additional, and Brucki, Sonia Maria Dozzi, additional

Published
2023
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16. Amyloid burden was associated with worse memory performance but no associated with conversion to mild cognitive impairment in SuperAgers

Author

Neto, Adalberto Studart, primary, Coutinho, Artur Martins, additional, Carneiro, Camila de Godoi, additional, Moraes, Natália Cristina, additional, Aranha, Mateus Rozalem, additional, Spera, Raphael Ribeiro, additional, Parmera, Jacy Bezerra, additional, Yassuda, Monica Sanches, additional, Brucki, Sonia Maria Dozzi, additional, Leite, Claudia da Costa, additional, Buchpiguel, Carlos A, additional, and Nitrini, Ricardo, additional

Published
2023
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17. A population‐based investigation of brain changes related to Alzheimer’s disease in middle‐aged adults in Brazil

Author

Leite, Renata Elaine Paraizo, primary, Rodriguez, Roberta Diehl, additional, Socher, Karen L R, additional, Suemoto, Claudia Kimie, additional, Brucki, Sonia Maria Dozzi, additional, de Lucena Ferretti‐Rebustini, Renata Eloah, additional, Jacob‐Filho, Wilson, additional, Pasqualucci, Carlos Augusto, additional, Grinberg, Lea T., additional, and Nitrini, Ricardo, additional

Published
2023
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20. Culturally adapted cognitive assessment tool for Indigenous communities in Brazil: Content, construct, and criterion validity.

Author

Bezerra, Camila Carlos, Toledo, Noeli das Neves, da Silva, Diego Ferreira, da Silva, Fernanda Carini, Duarte, Vanessa Vasconcellos, Brucki, Sonia Maria Dozzi, Giudice, Dina Lo, Fonseca, Luciana Mascarenhas, and Souza‐Talarico, Juliana Nery

Subjects
INDIGENOUS peoples of South America, COGNITIVE bias, COGNITIVE ability, TEST validity, DEMENTIA
Abstract

INTRODUCTION: Initial dementia prevalence estimates have revealed a significant burden of the disease in Indigenous communities in Amazonas, Brazil. However, the need for culturally adapted cognitive tools poses a critical challenge when assessing cognitive performance in these communities. This study addressed this issue by culturally adapting and providing validity indicators for the Brazilian Indigenous Cognitive Assessment (BRICA) tool in Manaus, Brazil's urban multiethnic Indigenous community. METHODS: Using a three‐stage process and a stakeholder‐engaged approach, the BRICA tool was culturally adapted in an urban multiethnic Indigenous community from Manaus, Brazil. The content validity index (CVI) examined inter‐rater concordance between experts, while criterion and concurrent validity were performed using diagnostic consensus criteria in 141 Indigenous participants aged ≥ 50 years. RESULTS: Findings showed evidence of content validity in terms of equivalence aspects (scale CVI [S‐CVI] 0.93) and relevance ratings (S‐CVI 0.85) between expert panels. The identified cut‐off score of ≤ 33/39 on the BRICA demonstrated a sensitivity of 94.4%, specificity of 99.2%, positive predictive value of 94.4%, and negative predictive value of 99.2% for dementia diagnosis. DISCUSSION: Using a stakeholder‐engaged approach, we culturally adapted the BRICA tool for a Brazilian urban multiethnic Indigenous community. This comprehensive adaptation process resulted in favorable indicators of content, construct, and criteria validity for the BRICA tool. By addressing the existing bias in cognitive assessment within Indigenous communities, the BRICA tool represents a noteworthy breakthrough. Its implementation exhibits potential for improving the early detection and management of dementia among Indigenous groups. Highlights: Culturally sensitive tools are essential to assess cognition in Indigenous populations.An expert panel and stakeholders' perspectives were incorporated to design the Brazilian Indigenous Cognitive Assessment (BRICA) tool.A cognitive screening tool was adapted and validated using a stakeholder approach.BRICA is the first culturally sensitive cognitive tool for urban Brazilian Indigenous individuals. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Probable 4‐Repeat Tauopathy Criteria Predict Brain Amyloid Negativity, Distinct Clinical Features, and FDG‐PET/MRI Neurodegeneneration Patterns in Corticobasal Syndrome.

Author

Parmera, Jacy Bezerra, de Godoi Carneiro, Camila, de Almeida, Isabel Junqueira, de Oliveira, Marcos Castello Barbosa, Barbosa, Pedro Melo, Studart‐Neto, Adalberto, Ono, Carla Rachel, Nitrini, Ricardo, Buchpiguel, Carlos Alberto, Barbosa, Egberto Reis, Brucki, Sonia Maria Dozzi, and Coutinho, Artur Martins

Subjects
PROGRESSIVE supranuclear palsy, TAUOPATHIES, MOTOR cortex, POSITRON emission tomography, AMYLOID, DYSARTHRIA
Abstract

Background: Corticobasal syndrome (CBS) is associated with diverse underlying pathologies, including the four‐repeat (4R)‐tauopathies. The Movement Disorders Society (MDS) criteria for progressive supranuclear palsy (PSP) proposed the novel category "probable 4R‐tauopathy" to address the phenotypic overlap between PSP and corticobasal degeneration (CBD). Objectives: To investigate the clinical ability of the MDS‐PSP criteria for probable 4R‐tauopathy in predicting a negative amyloid‐PET in CBS. Additionally, this study aims to explore CBS patients classified as 4R‐tauopathy concerning their clinical features and neuroimaging degeneration patterns. Methods: Thirty‐two patients with probable CBS were prospectively evaluated and split into those who fulfilled or did not fulfill the 4R‐tauopathy criteria (CBS‐4RT+ vs. CBS‐4RT−). All patients underwent positron emission tomographies (PET) with [18F]fluorodeoxyglucose and [11C]Pittsburgh Compound‐B (PIB) on a hybrid PET‐MRI scanner to perform multimodal quantitative comparisons with a control group. Results: Eleven patients were clinically classified as CBS‐4RT+, and only one had a positive PIB‐PET. The CBS‐4RT+ classification had 92% specificity, 52% sensitivity, and 69% accuracy in predicting a negative PIB‐PET. The CBS‐4RT+ group presented with dysarthria and perseveration more often than the CBS‐4RT− group. Moreover, the CBS‐4RT+ group showed a prominent frontal hypometabolism extending to the supplementary motor area and striatum, and brain atrophy at the anterior cingulate and bilateral striata. Conclusions: The 4R‐tauopathy criteria were highly specific in predicting a negative amyloid‐PET in CBS. Patients classified as 4R‐tauopathy presented distinct clinical aspects, as well as brain metabolism and atrophy patterns previously associated with tauopathies. [ABSTRACT FROM AUTHOR]

Published
2024
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22. COVID-19 and Cognitive and Mental Health During Post-Infection Phase: A Study Among Middle-Aged and Older Indigenous Adults From Brazilian Amazons.

Author

Bezerra, Camila Carlos, Toledo, Noeli das Neves, Brucki, Sonia Maria Dozzi, and Souza-Talarico, Juliana Nery

Subjects
COGNITION disorder risk factors, MENTAL illness risk factors, WELL-being, MEMORY, RESEARCH, COVID-19, HAPPINESS, MINORITIES, SCIENTIFIC observation, SELF-evaluation, CROSS-sectional method, COMMUNICATIVE competence, FUNCTIONAL status, AGE distribution, REGRESSION analysis, RISK assessment, NEUROPSYCHOLOGICAL tests, LEARNING, SEX distribution, PSYCHOSOCIAL factors, MENTAL depression, DESCRIPTIVE statistics, HOSPITAL care, COGNITIVE testing, INDIGENOUS peoples, METROPOLITAN areas, LOGISTIC regression analysis, STATISTICAL correlation, PSYCHOLOGICAL stress, MIDDLE age, OLD age
Abstract

Objectives To examine the rate of self-reported coronavirus disease-2019 (COVID-19) and its association with mental and cognitive health during the post-infection phase among middle-aged and older indigenous adults. Methods A cross-sectional study was conducted, including 141 individuals ≥50 and over from an urban indigenous community in Amazonas, Brazil. COVID-19 was deduced from self-reported infections. Cognitive function was evaluated using the Mini-Mental State Exam, Brief Cognitive Screening Battery (BCSB), and language fluency tests. Meanwhile, mental health was assessed through validated scales examining happiness, stress, and depression symptoms. The association between the rate of COVID-19 and cognitive and mental well-being was analyzed using logistic and linear regressions, adjusted for covariates. Results From March 2020 to February 2022, 65.2% of the urban indigenous group tested positive for COVID-19. Lower functional capacity decreased the odds of contracting COVID-19 (p  = .03). Adjusted linear regression models showed that COVID-19 was associated with higher BCSB learning (p  = .017) and delayed recall (p  = .028). Women, higher age, lower functional capacity, and hospitalization were associated with worse cognitive performance (p  < .05). No impact of mental health indicators on past COVID-19 infection was noted. Discussion COVID-19 was prevalent among urban Indigenous Brazilians. Unexpectedly, it was linked to enhanced learning and memory, not mental health issues. Cognitive performance was lower for men, older individuals, those with less functional ability, and hospitalized patients, indicating that participant characteristics and disease severity affect the COVID-19 and cognition relationship. Longitudinal studies across diverse Indigenous communities are necessary to understand COVID-19's impact on their cognitive and mental health. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Post-Mortem diagnosis of dementia by informant interview.

Author

Ferretti, Renata Eloah de Lucena, Damin, Antonio Eduardo, Brucki, Sonia Maria Dozzi, Morillo, Lilian Schafirovits, Perroco, Tibor Rilho, Campora, Flávia, Moreira, Eliza Guccione, Balbino, Érika Silvério, Lima, Maria do Carmo de Ascenção, Battela, Camila, Ruiz, Lumena, Grinberg, Lea Tenenholz, Farfel, José Marcelo, Leite, Renata Elaine Paraiso, Suemoto, Claudia Kimie, Pasqualucci, Carlos Augusto, Rosemberg, Sérgio, Saldiva, Paulo Hilário Nascimento, Jacob-Filho, Wilson, and Nitrini, Ricardo

Subjects
aging, brain bank, dementia, informant-interview, postmortem diagnosis
Abstract

The diagnosis of normal cognition or dementia in the Brazilian Brain Bank of the Aging Brain Study Group (BBBABSG) has relied on postmortem interview with an informant. Objectives:To ascertain the sensitivity and specificity of postmortem diagnosis based on informant interview compared against the diagnosis established at a memory clinic. Methods:A prospective study was conducted at the BBBABSG and at the Reference Center for Cognitive Disorders (RCCD), a specialized memory clinic of the Hospital das Clínicas, University of São Paulo Medical School. Control subjects and cognitively impaired subjects were referred from the Hospital das Clínicas to the RCCD where subjects and their informants were assessed. The same informant was then interviewed at the BBBABSG. Specialists' panel consensus, in each group, determined the final diagnosis of the case, blind to other center's diagnosis. Data was compared for frequency of diagnostic equivalence. For this study, the diagnosis established at the RCCD was accepted as the gold standard. Sensitivity and specificity were computed. Results:Ninety individuals were included, 45 with dementia and 45 without dementia (26 cognitively normal and 19 cognitively impaired but non-demented). The informant interview at the BBBABSG had a sensitivity of 86.6% and specificity of 84.4% for the diagnosis of dementia, and a sensitivity of 65.3% and specificity of 93.7% for the diagnosis of normal cognition. Conclusions:The informant interview used at the BBBABSG has a high specificity and sensitivity for the diagnosis of dementia as well as a high specificity for the diagnosis of normal cognition.

Published
2010

26. Current clinical and research practices on frontotemporal dementia in Brazil: a national survey

Author

Souza, Leonardo Cruz de, additional, Brucki, Sonia Maria Dozzi, additional, Schilling, Lucas Porcello, additional, Silva, Letícia Costa da, additional, Takada, Leonel Tadao, additional, Bahia, Valéria Santoro, additional, Barbosa, Breno José Alencar Pires, additional, Balthazar, Marcio Luiz Figueredo, additional, Frota, Norberto Anizio Ferreira, additional, Nitrini, Ricardo, additional, Caramelli, Paulo, additional, and Smid, Jerusa, additional

Published
2023
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27. The (in)visible Brazilians: A perspective review on the need for brain health and dementia research with Brazilian immigrants in the United States

Author

Simon, Sharon Sanz, primary, Brucki, Sonia Maria Dozzi, additional, Fonseca, Luciana Mascarenhas, additional, Becker, Jacqueline, additional, Cappi, Carolina, additional, Marques, Andrea Horvath, additional, Heyn, Patricia C., additional, Gonçalves, Priscila Dib, additional, Martins, Silvia S., additional, Busatto, Geraldo, additional, Bertola, Laiss, additional, Suemoto, Claudia Kimie, additional, Nitrini, Ricardo, additional, Caramelli, Paulo, additional, Yassuda, Monica Sanches, additional, Miotto, Eliane Correa, additional, Grinberg, Lea Tenenholz, additional, Arce Renteria, Miguel, additional, Alegria, Margarita, additional, Stern, Yaakov, additional, and Rivera‐Mindt, Monica, additional

Published
2023
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28. Latin American Initiative for Lifestyle Intervention to Prevent Cognitive Decline (LatAm‐FINGERS): Study design and harmonization

Author

Crivelli, Lucia, primary, Calandri, Ismael Luis, additional, Suemoto, Claudia Kimie, additional, Salinas, Rosa María, additional, Velilla, Lina Marcela, additional, Yassuda, Mônica Sanches, additional, Caramelli, Paulo, additional, Lopera, Francisco, additional, Nitrini, Ricardo, additional, Sevlever, Gustavo Emilio, additional, Sosa, Ana Luisa, additional, Acosta, Daisy, additional, Baietti, Ana María Charamelo, additional, Cusicanqui, María Isabel, additional, Custodio, Nilton, additional, De Simone, Sergio Dansilio, additional, Derio, Carolina Delgado, additional, Duque‐Peñailillo, Lissette, additional, Duran, Juan Carlos, additional, Jiménez‐Velázquez, Ivonne Z., additional, Leon‐Salas, Jorge Mario, additional, Bergamo, Yanina, additional, Clarens, María Florencia, additional, Damian, Andrés, additional, Demey, Ignacio, additional, Helou, María Belén, additional, Márquez, Carlos, additional, Martin, María Eugenia, additional, Martin, Maria da Graça Morais, additional, Querze, Diego, additional, Surace, Ezequiel Ignacio, additional, Acosta‐Egea, Sabrina, additional, Aguirre–Salvador, Esteban, additional, de Souza, Leonardo Cruz, additional, Cançado, Gustavo Henrique da Cunha Peixoto, additional, Brucki, Sonia Maria Dozzi, additional, Friedlaender, Clarisse Vasconcelos, additional, Gomes, Karina Braga, additional, Gutierrez, Myriam, additional, Ríos, Carlos Laforcada, additional, Galindo, Joyce Graciela Martinez, additional, Montesinos, Rosa, additional, Nuñez‐Herrera, Alberto, additional, Ospina‐Henao, Sebastián, additional, Rodríguez, Guillermina, additional, Masson, Victoria Ruiz, additional, Sánchez, Mónica, additional, Schenk, Christian E., additional, Soto, Ligia, additional, Barbosa, Maira Tonidandel, additional, Tosatti, Jéssica Abdo Gonçalves, additional, Vicuña, Yosselin, additional, Espeland, Mark, additional, Hakansson, Krister, additional, Kivipelto, Miia, additional, Baker, Laura, additional, Snyder, Heather, additional, Carrillo, María, additional, and Allegri, Ricardo Francisco, additional

Published
2023
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29. Effects of cognitive interventions with video games on cognition in healthy elderly people: a systematic review

Author

Ishibashi, Graciela Akina, additional, Santos, Gabriela dos, additional, Moreira, Ana Paula Bagli, additional, Verga, Cássia Elisa Rossetto, additional, Silva, Guilherme Alves da, additional, Ordonez, Tiago Nascimento, additional, Moraes, Luiz Carlos de, additional, Lessa, Patrícia Prata, additional, Brucki, Sonia Maria Dozzi, additional, and Silva, Thais Bento Lima da, additional

Published
2023
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30. Subjective impacts of computerized cognitive training for healthy older adults in the context of the COVID-19 pandemic

Author

Viviani, Cristiane Benedita Rodrigues da Mota Antunes, Ordonez, Tiago Nascimento, Pereira, Andreia Rodrigues, Jardim, Karen de Souza, Borges, Jonatas da Hora, Mota, Lais Aparecida Pereira, Santos, Gabriela dos, Moreira, Ana Paula Bagli, Verga, Cássia Elisa Rossetto, Ishibashi, Graciela Akina, Silva, Guilherme Alves da, Moraes, Luiz Carlos de, Lessa, Patrícia Prata, Gutierrez, Beatriz Aparecida Ozello, Brucki, Sonia Maria Dozzi, and Silva, Thais Bento Lima da

Subjects
Digital Technology, Cognition, Cognitive Aging, Tecnologia Digital, Idoso, Quality of Life, Envelhecimento Cognitivo, Cognição, Aged, Qualidade de Vida
Abstract

Background Computerized cognitive training programs may have benefited the self-assessment of memory, quality of life, and mood among older adults during the coronavirus disease 2019 (COVID-19) pandemic. Objective To determine the subjective impacts of computerized cognitive training on mood, frequency of forgetfulness, memory complaints, and quality of life in the elderly using an online platform. Methods In total, 66 elderly participants of USP 60 +, a program for the elderly offered by Universidade de São Paulo, who voluntarily enrolled in the study were selected and randomized with an allocation ratio of 1:1 into 2 groups: the training group (n = 33) and the control group (n = 33). After signing the free and informed consent form, they answered a protocol which included a sociodemographic questionnaire, the Memory Complaints Questionnaire (MAC-Q), the McNair and Kahn’s Frequency of Forgetfulness Scale, the Geriatric Depression Scale (GDS-15), the Geriatric Anxiety Inventory (GAI), and the Control, Autonomy, Self-Realization, and Pleasure (CASP-19) questionnaire. The training cognitive game platform aimed to stimulate various cognitive aspects, including memory, attention, language, executive functions (reasoning, logical thinking), and visual and spatial skills. Results The participants of the training group showed a reduction in the MAC-Q, MacNair and Kahn, and GAI scores in the pre- and posttest comparison. Significant differences were identified between the groups regarding the total scores of the MAC-Q in the post-test, which was also evidenced by the logistic regression. Conclusion Participation in a computerized cognitive intervention promoted reductions in memory complaints, frequency of forgetfulness, and anxiety symptoms, in addition to improving self-reported quality of life. Resumo Antecedentes Programas informatizados de treinamento cognitivo podem ter beneficiado a autoavaliação da memória, a qualidade de vida e o humor entre os idosos durante a pandemia de doença do coronavírus 2019 (coronavirus disease 2019, COVID-19, em inglês). Objetivo Determinar os impactos subjetivos do treinamento cognitivo computadorizado no humor, na frequência de esquecimento, nas queixas de memória, e na qualidade de vida em idosos utilizando uma plataforma online. Métodos Ao todo, 66 idosos participantes do programa USP 60 +, oferecido à terceira idade pela Universidade de São Paulo, e inscritos voluntariamente no estudo, foram selecionados e randomizados em uma razão de 1:1 em 2 grupos: grupo treinamento (n = 33) e grupo controle (n = 33). Após assinarem o termo de consentimento livre e esclarecido, os participantes responderam a um protocolo que incluía um questionário sociodemográfico, o Questionário de Queixas de Memória (Memory Complaints Questionnaire, MAC-Q), A Escala de Frequência de Esquecimento de McNair e Kahn, a Escala de Depressão Geriátrica (Geriatric Depression Scale, GDS-15), o Inventário de Ansiedade Geriátrica (Geriatric Anxiety Inventory, GAI), e –o questionário de Controle, Autonomia, Autorrealização e Prazer (Control, Autonomy, Self-Realization, and Pleasure, CASP-19). A plataforma de jogos cognitivos de treinamento visou estimular diversos aspectos cognitivos, incluindo memória, atenção, linguagem, funções executivas (raciocínio, raciocínio lógico) e habilidades visuais e espaciais. Resultados Na comparação pré e pós-teste, os participantes do grupo de treinamento apresentaram redução nas pontuações do MAC-Q, da escala McNair e Kahn e do GAI. Diferenças significativas entre os grupos quanto às pontuações totais da escala MAC-Q no pós-teste também foram evidenciadas pela regressão logística. Conclusão A participação em uma intervenção cognitiva computadorizada promoveu reduções nas queixas de memória, frequência de esquecimento e sintomas de ansiedade, além de melhorar a qualidade de vida autorrelatada.

Published
2023

31. Exame cognitivo de Addenbrooke III: utilidade diagnóstica para detectar comprometimento cognitivo leve e demência na doença de Parkinson

Author

Sousa, Nariana Mattos Figueiredo and Brucki, Sonia Maria Dozzi

Subjects
Testes Neuropsicológicos, Parkinson Disease, Cognitive Dysfunction, Dementia, Neuropsychological Tests, Doença de Parkinson, Disfunção Cognitiva, Demência
Abstract

Background Cognitive deficit in Parkinson disease (PD) is an important cause of functional disability in these patients and early detection, with sensitive instruments, can contribute to longitudinal monitoring. Objective To investigate the diagnostic accuracy, sensitivity, and specificity of the Addenbrooke’s Cognitive Examination-III in patients with PD, using the comprehensive neuropsychological battery as reference method. Methods Cross-sectional, observational, case-control study. Setting: rehabilitation service. A total of 150 patients and 60 healthy controls matched for age, sex, and education. For level I assessment, Addenbrooke Cognitive Examination (ACE-III) was used. Level II assessment used a comprehensive neuropsychological battery of standardized tests for this population. All patients remained in on-state during the study. The diagnostic accuracy of the battery was investigated through the receiver operating characteristic (ROC) analysis. Results The clinical group was divided into 3 subgroups: normal cognition in Parkinson’s disease (NC-PD-16%), mild cognitive impairment due to Parkinson’s disease (MCI-PD-69.33%), and dementia due to Parkinson’s disease (D-PD-14.66%). ACE-III optimal cutoff scores for detecting MCI-PD and D-PD were 85/100 (sensitivity 58.65%, specificity 60%) and 81/100 points (sensitivity 77.27%, specificity 78.33%), respectively. Age was inversely associated with the performance of the scores (totals and domains of the ACE-III), while the level of education had a significantly positive correlation in the performance of these scores. Conclusions ACE-III is a useful battery for assessing the cognitive domains and to differentiate individuals with MCI-PD and D-PD from healthy controls. Future research, in a community setting, is necessary to provide discriminatory capacity of ACE-III in the different severities of dementia. Resumo Antecedentes O déficit cognitivo na doença de Parkinson (DP) é uma importante causa de incapacidade funcional nestes pacientes e a detecção precoce, com instrumentos sensíveis, pode contribuir para o acompanhamento longitudinal. Objetivo Investigar a acurácia diagnóstica, sensibilidade e especificidade do Exame Cognitivo de Addenbrooke-II em pacientes com DP, usando uma bateria neuropsicológica ampla como método de referência. Métodos Estudo transversal, observacional, caso-controle. Local: serviço de reabilitação. Um total de 150 pacientes e 60 controles saudáveis pareados por idade, sexo e escolaridade. Para avaliação do nível I, foi utilizada a Addenbrooke Cognitive Examination (ACE-III). A avaliação do nível II utilizou o exame neuropsicológico, com testes padronizados para esta população. Todos os pacientes estavam na fase “on” da medicação. A acurácia diagnóstica da bateria foi investigada por meio da análise do receiver operating characteristic (ROC, na sigla em inglês). Resultados O grupo clínico foi dividido em 3 subgrupos: cognição normal na DP (CN-DP-16%), comprometimento cognitivo leve devido à DP (CCL-DP-69,33%) e demência devido à DP (D-DP-14,66%). As notas de corte ideais da ACE-III para detectar CCL-DP e D-DP foram 85/100 (sensibilidade 58,65%, especificidade 60%) e 81/100 pontos (sensibilidade 77,27%, especificidade 78,33%), respectivamente. A idade associou-se inversamente com o desempenho dos escores (totais e domínios da ACE-III), enquanto a faixa de escolaridade apresentou correlação significativamente positiva no desempenho destes escores. Conclusões A ACE-III é uma bateria útil para avaliação de domínios cognitivos e diferenciar indivíduos com CCL-DP e D-DP de controles saudáveis. Pesquisas futuras, em ambiente comunitário, são necessárias para fornecer capacidade discriminatória da ACE-III nos diferentes estágios da demência.

Published
2023

33. Subjective impacts of computerized cognitive training for healthy older adults in the context of the COVID-19 pandemic

Author

Viviani, Cristiane Benedita Rodrigues da Mota Antunes, additional, Ordonez, Tiago Nascimento, additional, Pereira, Andreia Rodrigues, additional, Jardim, Karen de Souza, additional, Borges, Jonatas da Hora, additional, Mota, Lais Aparecida Pereira, additional, Santos, Gabriela dos, additional, Moreira, Ana Paula Bagli, additional, Verga, Cássia Elisa Rossetto, additional, Ishibashi, Graciela Akina, additional, Silva, Guilherme Alves da, additional, Moraes, Luiz Carlos de, additional, Lessa, Patrícia Prata, additional, Gutierrez, Beatriz Aparecida Ozello, additional, Brucki, Sonia Maria Dozzi, additional, and Silva, Thais Bento Lima da, additional

Published
2023
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34. Dissipating the fog: Cognitive trajectories and risk factors 1 year after COVID‐19 hospitalization.

Author

Gonçalves, Natalia Gomes, Aliberti, Márlon Juliano Romero, Bertola, Laiss, Avelino‐Silva, Thiago, Dias, Murilo Bacchini, Apolinario, Daniel, Busatto, Geraldo, Forlenza, Orestes, Nitrini, Ricardo, Brucki, Sonia Maria Dozzi, Brunoni, Andre Russowsky, Vidal, Kallene Summer Moreira, Jacob‐Filho, Wilson, and Suemoto, Claudia Kimie

Abstract

Introduction: Cognitive impairment is common after severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. However, associations between post‐hospital discharge risk factors and cognitive trajectories have not been explored. Methods: A total of 1105 adults (mean age ± SD 64.9 ± 9.9 years, 44% women, 63% White) with severe coronavirus disease 2019 (COVID‐19) were evaluated for cognitive function 1 year after hospital discharge. Scores from cognitive tests were harmonized, and clusters of cognitive impairment were defined using sequential analysis. Results: Three groups of cognitive trajectories were observed during the follow‐up: no cognitive impairment, initial short‐term cognitive impairment, and long‐term cognitive impairment. Predictors of cognitive decline after COVID‐19 were older age (β = −0.013, 95% CI = −0.023;−0.003), female sex (β = −0.230, 95% CI = −0.413;−0.047), previous dementia diagnosis or substantial memory complaints (β = −0.606, 95% CI = −0.877;−0.335), frailty before hospitalization (β = −0.191, 95% CI = −0.264;−0.119), higher platelet count (β = −0.101, 95% CI = −0.185;−0.018), and delirium (β = −0.483, 95% CI = −0.724;−0.244). Post‐discharge predictors included hospital readmissions and frailty. Discussion: Cognitive impairment was common and the patterns of cognitive trajectories depended on sociodemographic, in‐hospital, and post‐hospitalization predictors. Highlights: Cognitive impairment after coronavirus disease 2019 (COVID‐19) hospital discharge was associated with higher age, less education, delirium during hospitalization, a higher number of hospitalizations post discharge, and frailty before and after hospitalization.Frequent cognitive evaluations for 12‐month post‐COVID‐19 hospitalization showed three possible cognitive trajectories: no cognitive impairment, initial short‐term impairment, and long‐term impairment.This study highlights the importance of frequent cognitive testing to determine patterns of COVID‐19 cognitive impairment, given the high frequency of incident cognitive impairment 1 year after hospitalization. [ABSTRACT FROM AUTHOR]

Published
2023
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37. Follow-up of participants with subjective cognitive decline from Tremembé epidemiologic study, Brazil

Author

César-Freitas, Karolina Gouveia, primary, Berardis, Ana Catarina Penalva, additional, Pretto, Thaísa Valentim Moreira, additional, Viagi, Amanda Monteiro, additional, Lourençon Neto, Vitorio, additional, Zanini, Leonardo Yuri Kasputis, additional, Barbosa, Isabella Caroline Callegari, additional, Machado, Rubya Pasquarelli, additional, Cunha, Natália Gomes Manso, additional, Watanabe, Maria Júlia Lumi, additional, Cecchini, Mario Amore, additional, Brucki, Sonia Maria Dozzi, additional, and Nitrini, Ricardo, additional

Published
2023
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40. Effects of working memory training on cognition in healthy older adults: A systematic review

Author

Lima-Silva, Thais Bento, primary, Ordonez, Tiago Nascimento, additional, Santos, Gabriela dos, additional, Moreira, Ana Paula Bagli, additional, Verga, Cássia Elisa Rosseto, additional, Ishibashi, Graciela Akina, additional, Silva, Guilherme Alves da, additional, Prata, Patrícia Lessa, additional, Moraes, Luiz Carlos de, additional, and Brucki, Sonia Maria Dozzi, additional

Published
2022
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43. Discovery and validation of dominantly Inherited Alzheimer’s Disease mutations in populations from Latin America.

Author

Llibre‐Guerra, Jorge J, primary, Takada, Leonel Tadao, additional, Verson, Carmen Alaez, additional, Burgute, Bhagyashri, additional, Nitrini, Ricardo, additional, Sosa‐Ortiz, Ana Luisa, additional, Castilhos, Raphael Machado, additional, Chaves, Marcia L Fagundes, additional, Ibarrola, Mariana Longoria, additional, Carrillo‐Sanchez, Karol, additional, Brucki, Sonia Maria Dozzi, additional, Flores‐Lagunes, Luis Leonardo, additional, Molina, Carolina, additional, Olivares, Marcos Jimenez, additional, Ziegemeier, Ellen, additional, Goate, Alison M., additional, Cruchaga, Carlos, additional, Renton, Alan E., additional, Fernandez, Maria Victoria, additional, Day, Gregory S, additional, McDade, Eric, additional, Bateman, Randall J., additional, and Karch, Celeste M., additional

Published
2022
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44. Diagnosis of Alzheimer’s disease: recommendations of the Scientific Department of Cognitive Neurology and Aging of the Brazilian Academy of Neurology

Author

Schilling, Lucas Porcello, primary, Balthazar, Marcio Luiz Figueredo, additional, Radanovic, Márcia, additional, Forlenza, Orestes Vicente, additional, Silagi, Marcela Lima, additional, Smid, Jerusa, additional, Barbosa, Breno José Alencar Pires, additional, Frota, Norberto Anízio Ferreira, additional, Souza, Leonardo Cruz de, additional, Vale, Francisco Assis Carvalho, additional, Caramelli, Paulo, additional, Bertolucci, Paulo Henrique Ferreira, additional, Chaves, Márcia Lorena Fagundes, additional, Brucki, Sonia Maria Dozzi, additional, Damasceno, Benito Pereira, additional, and Nitrini, Ricardo, additional

Published
2022
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45. Diagnóstico da doença de Alzheimer: recomendações do Departamento Científico de Neurologia Cognitiva e do Envelhecimento da Academia Brasileira de Neurologia

Author

Schilling, Lucas Porcello, primary, Balthazar, Marcio Luiz Figueredo, additional, Radanovic, Márcia, additional, Forlenza, Orestes Vicente, additional, Silagi, Marcela Lima, additional, Smid, Jerusa, additional, Barbosa, Breno José Alencar Pires, additional, Frota, Norberto Anízio Ferreira, additional, Souza, Leonardo Cruz de, additional, Vale, Francisco Assis Carvalho, additional, Caramelli, Paulo, additional, Bertolucci, Paulo Henrique Ferreira, additional, Chaves, Márcia Lorena Fagundes, additional, Brucki, Sonia Maria Dozzi, additional, Damasceno, Benito Pereira, additional, and Nitrini, Ricardo, additional

Published
2022
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46. Tratamento da demência: recomendações do Departamento Científico de Neurologia Cognitiva e do Envelhecimento da Academia Brasileira de Neurologia

Author

Caramelli, Paulo, primary, Marinho, Valeska, additional, Laks, Jerson, additional, Coletta, Marcus Vinicius Della, additional, Stella, Florindo, additional, Camargos, Einstein Francisco, additional, Smid, Jerusa, additional, Barbosa, Breno José Alencar Pires, additional, Schilling, Lucas Porcello, additional, Balthazar, Marcio Luiz Figueredo, additional, Frota, Norberto Anízio Ferreira, additional, Souza, Leonardo Cruz de, additional, Vale, Francisco Assis Carvalho, additional, Chaves, Márcia Lorena Fagundes, additional, Brucki, Sonia Maria Dozzi, additional, Nitrini, Ricardo, additional, Durgante, Helen Bedinoto, additional, and Bertolucci, Paulo Henrique Ferreira, additional

Published
2022
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47. Diagnóstico do comprometimento cognitivo vascular: recomendações do Departamento Científico de Neurologia Cognitiva e do Envelhecimento da Academia Brasileira de Neurologia

Author

Barbosa, Breno José Alencar Pires, primary, Siqueira Neto, José Ibiapina, additional, Alves, Gilberto Sousa, additional, Sudo, Felipe Kenji, additional, Suemoto, Claudia Kimie, additional, Tovar-Moll, Fernanda, additional, Smid, Jerusa, additional, Schilling, Lucas Porcello, additional, Balthazar, Marcio Luiz Figueredo, additional, Frota, Norberto Anízio Ferreira, additional, Souza, Leonardo Cruz de, additional, Vale, Francisco Assis Carvalho, additional, Caramelli, Paulo, additional, Bertolucci, Paulo Henrique Ferreira, additional, Brucki, Sonia Maria Dozzi, additional, Nitrini, Ricardo, additional, Engelhardt, Eliasz, additional, and Chaves, Márcia Lorena Fagundes, additional

Published
2022
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48. Management in severe dementia: recommendations of the Scientific Department of Cognitive Neurology and Aging of the Brazilian Academy of Neurology

Author

Brucki, Sonia Maria Dozzi, primary, Aprahamian, Ivan, additional, Borelli, Wyllians Vendramini, additional, Silveira, Victor Calil da, additional, Ferretti, Ceres Eloah de Lucena, additional, Smid, Jerusa, additional, Barbosa, Breno José Alencar Pires, additional, Schilling, Lucas Porcello, additional, Balthazar, Márcio Luiz Figueiredo, additional, Frota, Norberto Anízio Ferreira, additional, Souza, Leonardo Cruz de, additional, Vale, Francisco Assis Carvalho, additional, Caramelli, Paulo, additional, Bertolucci, Paulo Henrique Ferreira, additional, Chaves, Márcia Lorena Fagundes, additional, Nitrini, Ricardo, additional, Schultz, Rodrigo Rizek, additional, and Morillo, Lilian Schafirovits, additional

Published
2022
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49. Diagnóstico e manejo da demência da doença de Parkinson e demência com corpos de Lewy: recomendações do Departamento Científico de Neurologia Cognitiva e do Envelhecimento da Academia Brasileira de Neurologia

Author

Parmera, Jacy Bezerra, primary, Tumas, Vitor, additional, Ferraz, Henrique Ballalai, additional, Spitz, Mariana, additional, Barbosa, Maira Tonidandel, additional, Smid, Jerusa, additional, Barbosa, Breno José Alencar Pires, additional, Schilling, Lucas Porcello, additional, Balthazar, Márcio Luiz Figueiredo, additional, Souza, Leonardo Cruz de, additional, Vale, Francisco Assis Carvalho, additional, Caramelli, Paulo, additional, Bertolucci, Paulo Henrique Ferreira, additional, Chaves, Márcia Lorena Fagundes, additional, Brucki, Sonia Maria Dozzi, additional, Nitrini, Ricardo, additional, Castilhos, Raphael Machado, additional, and Frota, Norberto Anízio Ferreira, additional

Published
2022
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50. Diagnóstico da demência frontotemporal: recomendações do Departamento Científico de Neurologia Cognitiva e do Envelhecimento da Academia Brasileira de Neurologia

Author

Souza, Leonardo Cruz de, primary, Hosogi, Mirna Lie, additional, Machado, Thais Helena, additional, Carthery-Goulart, Maria Teresa, additional, Yassuda, Mônica Sanches, additional, Smid, Jerusa, additional, Barbosa, Breno José Alencar Pires, additional, Schilling, Lucas Porcello, additional, Balthazar, Marcio Luiz Figueredo, additional, Frota, Norberto Anízio Ferreira, additional, Vale, Francisco Assis Carvalho, additional, Caramelli, Paulo, additional, Bertolucci, Paulo Henrique Ferreira, additional, Chaves, Márcia Lorena Fagundes, additional, Brucki, Sonia Maria Dozzi, additional, Nitrini, Ricardo, additional, Bahia, Valéria Santoro, additional, and Takada, Leonel Tadao, additional

Published
2022
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