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5. Tinnitus

Author

Finnell, Josh, Piccirillo, Jay F., Bauer, Carol, Brozoski, Thomas J., Perring, Alison, Shin, Jennifer J., editor, Hartnick, Christopher J., editor, Randolph, Gregory W., editor, Cunningham, Michael J., editor, Kenna, Margaret, editor, Willging, J. Paul, editor, Nadol, Joseph B., Jr., editor, Rauch, Steven D., editor, Piccirillo, Jay F., editor, and Johnson, Jonas T., editor

Published
2008
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8. List of Contributors

Author

Agnati, L.F., primary, Bauer, Carol A., additional, Bautista, Tara G., additional, Blumenfeld, Hal, additional, Boccaccio, Anna, additional, Bordey, Angelique, additional, Brozoski, Thomas J., additional, Carlen, Peter L., additional, D'Ascenzo, Marcello, additional, Destexhe, Alain, additional, Devor, Marshall, additional, Dudek, F. Edward, additional, Dyhrfjeld-Johnsen, Jonas, additional, Faingold, Carl L., additional, Fellin, Tommaso, additional, Feng, Hua-Jun, additional, Ferris, Craig F., additional, Fort, Patrice, additional, Furman, Moran, additional, Fuxe, K., additional, Galanopoulou, Aristea S., additional, Garcia-Cairasco, Norberto, additional, Genedani, S., additional, Guidolin, D., additional, Guo, Jennifer N., additional, Gusev, Alexander G., additional, Halassa, Michael M., additional, Hamid, Hamada, additional, Jabbari, Bahman, additional, Jordan, Larry M., additional, Krager, Stacey L., additional, Lakraj, Amanda-Amrita D., additional, Lin, Tiffany V., additional, Luppi, Pierre-Hervé, additional, Machado, Duarte G., additional, Morris, Kendall F., additional, Moshé, Solomon L., additional, Motelow, Joshua, additional, N'Gouemo, Prosper, additional, Pilowsky, Paul M., additional, Pitts, Teresa E., additional, Raisinghani, Manish, additional, Riaz, Awais, additional, Sametsky, Evgeny A., additional, Schafe, Glenn E., additional, Sławińska, Urszula, additional, Spano, P.F., additional, Staley, Kevin, additional, Stittsworth, James D., additional, Sukhotinsky, Inna, additional, Swiercz, Waldemar, additional, Tenney, Jeffrey, additional, Tischkau, Shelley A., additional, Tupal, Srinivasan, additional, Uteshev, Victor V., additional, and Valiante, Taufik A., additional

Published
2014
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16. The effect of tinnitus retraining therapy on chronic tinnitus: A controlled trial

Author

Bauer, Carol A., Berry, Jennifer L., and Brozoski, Thomas J.

Subjects
chronic, randomized controlled trial, retraining therapy, otorhinolaryngologic diseases, Otology, Neurotology, and Neuroscience, tinnitus, hearing aids, Original Research
Abstract

Objectives The goal of this study was to compare treatment outcomes for chronic bothersome tinnitus after Tinnitus Retraining Therapy (TRT) versus standard of care treatment (SC) and to determine the longevity of the effect over an 18‐month period. Study Design A randomized controlled trial comparing TRT to SC for chronic tinnitus. Methods Adults with subjective, stable, bothersome chronic tinnitus associated with hearing loss amenable to aural rehabilitation with hearing aids were recruited. The Tinnitus Handicap Inventory (THI) was the primary outcome measure and the Tinnitus Functional Index (TFI) the secondary outcome measure of tinnitus severity and impact. Data were collected at screening, entry (0 months), and 6, 12, and 18 months after the beginning of treatment, using an integrated digitized suite of evaluation modules. TRT consisted of directive counseling and acoustic enrichment using combination hearing aids and sound generators; SC consisted of general aural rehabilitation counseling and hearing aids. Results Significant improvement in tinnitus impact occurred after both TRT and SC therapy, with a larger treatment effect obtained in the TRT group. Lasting therapeutic benefit was evident at 18 months in both groups. THI initial scores were unstable in 10% of enrolled participants, showing moderate bidirectional fluctuation between screening and baseline (0 month) assessment. Conclusion Adults with moderate to severe tinnitus and hearing loss amenable to amplification, benefit from either TRT or SC treatment when combined with hearing aid use. TRT benefit may exceed that of SC. The global improvement in tinnitus severity that accrued over an 18‐month period appeared to be robust and clinically significant. Level of Evidence I

Published
2017

43. Acoustic injury and TRPV1 expression in the cochlear spiral ganglion.

Author

Bauer CA, Brozoski TJ, and Myers KS

Subjects
Age Factors, Animals, Auditory Threshold physiology, Hyperacusis pathology, Immunoenzyme Techniques, Male, Neurons pathology, Rats, Rats, Long-Evans, Cochlea pathology, Hearing Loss, Noise-Induced pathology, Spiral Ganglion pathology, TRPV Cation Channels analysis, Tinnitus pathology
Abstract

Acoustic trauma not only produces temporary and permanent hearing loss but is a common cause of chronic tinnitus. Recent work indicated a possible role for the transient receptor potential channel vanilloid subfamily type 1 (TRPV1) in modulating the effects of cochlear injury. In our research, we investigated the effects of acoustic damage on TRPV1 expression in spiral ganglion neurons of adult rats. After exposing them unilaterally to noise, we extracted cochleas and processed the spiral ganglion for TRPV1 expression at four posttrauma intervals (2 hours, 24 hours, 12 days, and 16.9 months). We measured TRPV1 immunodensity in the apical, middle, and basal turns of the cochlea. We found a significant interaction (p = .039) between posttrauma interval and regional cochlear receptor expression: For survival intervals between 24 hours and 2 weeks, TRPV1 density increased in all cochlear regions; at the longest survival interval (16.9 months), TRPV1 density was dramatically reduced in the basal region. We also psychophysically tested the long-survival subjects, which showed evidence of 20-kHz tonal tinnitus. These results suggest that TRPV1 may participate after cochlear injury in a signal cascade that is responsible for the neuroplastic events leading to tinnitus and hyperacusis.

Published
2007

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