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2. Quantitative CT metrics are associated with longitudinal lung function decline and future asthma exacerbations: Results from SARP-3

Author

Krings, James G, Goss, Charles W, Lew, Daphne, Samant, Maanasi, McGregor, Mary Clare, Boomer, Jonathan, Bacharier, Leonard B, Sheshadri, Ajay, Hall, Chase, Brownell, Joshua, Schechtman, Ken B, Peterson, Samuel, McEleney, Stephen, Mauger, David T, Fahy, John V, Fain, Sean B, Denlinger, Loren C, Israel, Elliot, Washko, George, Hoffman, Eric, Wenzel, Sally E, Castro, Mario, and National Heart, Lung

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Lung, Asthma, Respiratory, Adult, Airway Remodeling, Disease Progression, Female, Forced Expiratory Volume, Humans, Male, Middle Aged, Prognosis, Tomography, X-Ray Computed, severe asthma, CT imaging, asthma morbidity, asthma exacerbations, longitudinal, lung function, National Heart, Lung, and Blood Institute’s Severe Asthma Research Program Investigators, Immunology, Allergy
Abstract

BackgroundCurrently, there is limited knowledge regarding which imaging assessments of asthma are associated with accelerated longitudinal decline in lung function.ObjectivesWe aimed to assess whether quantitative computed tomography (qCT) metrics are associated with longitudinal decline in lung function and morbidity in asthma.MethodsWe analyzed 205 qCT scans of adult patients with asthma and calculated baseline markers of airway remodeling, lung density, and pointwise regional change in lung volume (Jacobian measures) for each participant. Using multivariable regression models, we then assessed the association of qCT measurements with the outcomes of future change in lung function, future exacerbation rate, and changes in validated measurements of morbidity.ResultsGreater baseline wall area percent (β = -0.15 [95% CI = -0.26 to -0.05]; P < .01), hyperinflation percent (β = -0.25 [95% CI = -0.41 to -0.09]; P < .01), and Jacobian gradient measurements (cranial-caudal β = 10.64 [95% CI = 3.79-17.49]; P < .01; posterior-anterior β = -9.14, [95% CI = -15.49 to -2.78]; P < .01) were associated with more severe future lung function decline. Additionally, greater wall area percent (rate ratio = 1.06 [95% CI = 1.01-1.10]; P = .02) and air trapping percent (rate ratio =1.01 [95% CI = 1.00-1.02]; P = .03), as well as lower decline in the Jacobian determinant mean (rate ratio = 0.58 [95% CI = 0.41-0.82]; P < .01) and Jacobian determinant standard deviation (rate ratio = 0.52 [95% CI = 0.32-0.85]; P = .01), were associated with a greater rate of future exacerbations. However, imaging metrics were not associated with clinically meaningful changes in scores on validated asthma morbidity questionnaires.ConclusionsBaseline qCT measures of more severe airway remodeling, more small airway disease and hyperinflation, and less pointwise regional change in lung volumes were associated with future lung function decline and asthma exacerbations.

Published
2021

3. The Precision Interventions for Severe and/or Exacerbation-Prone (PrecISE) Asthma Network: An overview of Network organization, procedures, and interventions

Author

Billheimer, Dean, Bleecker, Eugene R., Branch, Emily, Conway, Michelle, Daines, Cori, Deaton, Isaac, Evans, Alexandria, Field, Paige, Francisco, Dave, Hastie, Annette T., Hmieleski, Bob, Krings, Jeffrey O., Liu, Yanqin, Merchen, Janell L., Meyers, Deborah A., Narendran, Nirushan, Peters, Stephen P., Pippins, Anna, Rank, Matthew A., Schunk, Ronald, Skeps, Raymond, Wright, Benjamin, Banzon, Tina M., Bartnikas, Lisa M., Baxi, Sachin N., Betapudi, Vishwanath, Brick, Isabelle, Brockway, Conor, Casale, Thomas B., Castillo-Ruano, Kathleen, Cinelli, Maria Angeles, Crestani, Elena, Cunningham, Amparito, Day-Lewis, Megan, Diaz-Cabrera, Natalie, DiMango, Angela, Esty, Brittany, Fandozzi, Eva, Fernandez, Jesse, Fitzpatrick, Elizabeth, Forth, Victoria E., Gentile, Katarina, Gubernick, David, Gueye-Ndiaye, Seyni, Gunnlaagsson, Sigfus, Hauptmann, Marissa, Hudey, Stephanie N., Imanirad, Donya S., Kaage, Tiffani, Kolinsky, Nicholas, LaBere, Brenna, Lai, Peggy Sue, Le, Meghan, Ledford, Dennis K., Lockey, Richard, Louisias, Margee, Macginnitie, Andrew J., Maciag, Michelle C., O’Neill, Allison, Pepper, Amber N., Permaul, Perdita, Pugh, Mya, Queheillalt, Dianna, Saroya, Tarnjot, Sheehan, William, Smith, Catherine, Socolovsky, Carmela, Treffeisen, Else, Trippa, Lorenzo, Tulchinsky, Abigail, Yee, Christina, Carter, Tina, Fu, Jun, Garcia, Vanessa, Hixon, Jenny, Jackson, Carly, Ji, Yuan, Kalhan, Ravi, Kaur, Opinderjit, Li, Grace, Makhija, Melanie M., Maleckar, Spring, Naureckas, Edward T., Peters, Anju T., Press, Valerie, Qureshi, Mehreen, Reyfman, Paul A., Rosenberg, Sharon R., Ryba, Dominika, Sheng, Jianrong, Xu, Ben, Alam, Rafeul, Anderson, Darci, Belimezova, Sonya, Bitzan, Jennifer, Chupp, Geoffrey, Clark, Brian J., Cohn, Lauren, Cruse, Margaret Hope, Estrom, Jean, Freid, Leah, Villalobos, Jose Gomez, Grant, Nicole, Guntur, Vamsi P., Holm, Carole, Kolakowski, Christena, Manka, Laurie A., Miyazawa, Naomi, Pak, Juno, Pruitt, Diana M., Sharma, Sunita, Stevens, Allen D., Thomas, Kisori, Tippin, Brooke, Valente, Karissa, Wainscoat, Cynthia L., White, Michael P., Winnica, Daniel, Ye, Shuyu, Zeitlin, Pamela L., Bach, Julia, Brownell, Joshua, Castro, Lauren, DeLisa, Julie, Fain, Sean B., Fichtinger, Paul S., Floerke, Heather, Gern, James E., Goswamy, Vinay, Grogan, Jenelle, Hasse, Wendy, Kelley, Rick L., Klaus, Danika, LaBedz, Stephanie, Lowell, Paige, Maddox, Andrew, Mathur, Sameer K., McIntyre, Amanda, Norwick, Lourdes M., Nyenhuis, Sharmilee M., O’Brien, Matthew J., Palas, Tina, Pappalardo, Andrea A., Potter, Mark, Ramratnam, Sima K., Rosenberg, Daniel L., Schauberger, Eric M., Schiebler, Mark L., Schraml, Angela, Sorkness, Ronald L., Taki, Mohamed, Tattersall, Matthew C., Torres, Jissell, Wollet, Lori, Abi-Saleh, Simon, Bendy, Lisa, Borish, Larry, Chmiel, James F., Dix, Aska, France, Lisa, Gammell, Rebecca, Gluvna, Adam, Hirth, Brittany, Hu, Bo, Hyser, Elise, Kloepfer, Kirsten M., Koo, Michelle, Krupp, Nadia L., Labadia, Monica, Lawrence, Joy, Logan, Laurie, Marko, Angela, Matuska, Brittany, Murphy, Deborah, Owensby, Rachel, Roesch, Erica A., Sanders, Don B., Sharp, Jackie, Teague, W. Gerald, Veri, Laura, Shifflett, Kristin Wavell, Camiolo, Matt, Collins, Sarah, Demas, Jessa, Elvin, Courtney, Gauthier, Marc C., Ilnicki, Melissa, Ingram, Jenn, Lane, Lisa, Nouraie, Seyed Mehdi, Trudeau, John B., Zhang, Michael, Barry, Jeffrey, Brickner, Howard, Celso, Janelle, Cernelc-Kohan, Matejka, Diaz, Damaris, Du, Ashley, Jain, Sonia, Liu, Neiman, Nazir, Yusife, Ryu, Julie, Vijayanand, Pandurangan, Almario, Rogelio, Baum, Ariana, Brown, Kellen, Chan, Marilynn H., Gale, Barbara, Haczku, Angela, Harper, Richart W., Heromin, Raymond, Kivler, Celeste, Kuhn, Brooks T., Ly, Ngoc P., McCourt, Paula, Orain, Xavier, Plough, Audrey, Ramirez, Karla, Roberts, Ellese, Schivo, Michael, Singapuri, Amisha, Tham, Tina, Tompkins, Daniel, Twitmyer, Patricia Michelle, Vi, Jade, Atha, Jarron, Bedard, Jennifer, Boomer, Jonathan S., Chung, Andrew, Curtis, Vanessa, Hall, Chase S., Hart, Emily, Jackson, Fatima, Kemp, Pamela, Maxwell, Sharli, Messplay, Maggie, Ramirez, Crystal, Thompson, Brynne, Britt, Ashley, Bryan, Hope, Gotman, Nathan M., Jiang, Yue, Kosorok, Michael R., Mauger, David T., Meekins, Kelsey, Mollenhauer, Jeanette K., Moody, Sarah, Ritz, Cheyanne, Schwartz, Stefanie, Thomlinson, Chalmer, Wilson, Nicole, Georas, Steve N., Wright, Rosalind J., Ivanova, Anastasia, Israel, Elliot, LaVange, Lisa M., Akuthota, Praveen, Carr, Tara F., Denlinger, Loren C., Fajt, Merritt L., Kumar, Rajesh, O’Neal, Wanda K., Phipatanakul, Wanda, Szefler, Stanley J., Aronica, Mark A., Bacharier, Leonard B., Burbank, Allison J., Castro, Mario, Crotty Alexander, Laura, Bamdad, Julie, Cardet, Juan Carlos, Comhair, Suzy A.A., Covar, Ronina A., DiMango, Emily A., Erwin, Kim, Erzurum, Serpil C., Fahy, John V., Gaffin, Jonathan M., Gaston, Benjamin, Gerald, Lynn B., Hoffman, Eric A., Holguin, Fernando, Jackson, Daniel J., James, John, Jarjour, Nizar N., Kenyon, Nicholas J., Khatri, Sumita, Kirwan, John P., Kraft, Monica, Krishnan, Jerry A., Liu, Andrew H., Liu, Mark C., Marquis, M. Alison, Martinez, Fernando, Mey, Jacob, Moore, Wendy C., Moy, James N., Ortega, Victor E., Peden, David B., Pennington, Emily, Peters, Michael C., Ross, Kristie, Sanchez, Maria, Smith, Lewis J., Wechsler, Michael E., Wenzel, Sally E., White, Steven R., Zein, Joe, Zeki, Amir A., and Noel, Patricia

Published
2022
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6. The Precision Interventions for Severe and/or Exacerbation-Prone (PrecISE) Asthma Network: An overview of Network organization, procedures, and interventions

Author

Georas, Steve N., primary, Wright, Rosalind J., additional, Ivanova, Anastasia, additional, Israel, Elliot, additional, LaVange, Lisa M., additional, Akuthota, Praveen, additional, Carr, Tara F., additional, Denlinger, Loren C., additional, Fajt, Merritt L., additional, Kumar, Rajesh, additional, O’Neal, Wanda K., additional, Phipatanakul, Wanda, additional, Szefler, Stanley J., additional, Aronica, Mark A., additional, Bacharier, Leonard B., additional, Burbank, Allison J., additional, Castro, Mario, additional, Crotty Alexander, Laura, additional, Bamdad, Julie, additional, Cardet, Juan Carlos, additional, Comhair, Suzy A.A., additional, Covar, Ronina A., additional, DiMango, Emily A., additional, Erwin, Kim, additional, Erzurum, Serpil C., additional, Fahy, John V., additional, Gaffin, Jonathan M., additional, Gaston, Benjamin, additional, Gerald, Lynn B., additional, Hoffman, Eric A., additional, Holguin, Fernando, additional, Jackson, Daniel J., additional, James, John, additional, Jarjour, Nizar N., additional, Kenyon, Nicholas J., additional, Khatri, Sumita, additional, Kirwan, John P., additional, Kraft, Monica, additional, Krishnan, Jerry A., additional, Liu, Andrew H., additional, Liu, Mark C., additional, Marquis, M. Alison, additional, Martinez, Fernando, additional, Mey, Jacob, additional, Moore, Wendy C., additional, Moy, James N., additional, Ortega, Victor E., additional, Peden, David B., additional, Pennington, Emily, additional, Peters, Michael C., additional, Ross, Kristie, additional, Sanchez, Maria, additional, Smith, Lewis J., additional, Sorkness, Ronald L., additional, Wechsler, Michael E., additional, Wenzel, Sally E., additional, White, Steven R., additional, Zein, Joe, additional, Zeki, Amir A., additional, Noel, Patricia, additional, Billheimer, Dean, additional, Bleecker, Eugene R., additional, Branch, Emily, additional, Conway, Michelle, additional, Daines, Cori, additional, Deaton, Isaac, additional, Evans, Alexandria, additional, Field, Paige, additional, Francisco, Dave, additional, Hastie, Annette T., additional, Hmieleski, Bob, additional, Krings, Jeffrey O., additional, Liu, Yanqin, additional, Merchen, Janell L., additional, Meyers, Deborah A., additional, Narendran, Nirushan, additional, Peters, Stephen P., additional, Pippins, Anna, additional, Rank, Matthew A., additional, Schunk, Ronald, additional, Skeps, Raymond, additional, Wright, Benjamin, additional, Banzon, Tina M., additional, Bartnikas, Lisa M., additional, Baxi, Sachin N., additional, Betapudi, Vishwanath, additional, Brick, Isabelle, additional, Brockway, Conor, additional, Casale, Thomas B., additional, Castillo-Ruano, Kathleen, additional, Cinelli, Maria Angeles, additional, Crestani, Elena, additional, Cunningham, Amparito, additional, Day-Lewis, Megan, additional, Diaz-Cabrera, Natalie, additional, DiMango, Angela, additional, Esty, Brittany, additional, Fandozzi, Eva, additional, Fernandez, Jesse, additional, Fitzpatrick, Elizabeth, additional, Forth, Victoria E., additional, Gentile, Katarina, additional, Gubernick, David, additional, Gueye-Ndiaye, Seyni, additional, Gunnlaagsson, Sigfus, additional, Hauptmann, Marissa, additional, Hudey, Stephanie N., additional, Imanirad, Donya S., additional, Kaage, Tiffani, additional, Kolinsky, Nicholas, additional, LaBere, Brenna, additional, Lai, Peggy Sue, additional, Le, Meghan, additional, Ledford, Dennis K., additional, Lockey, Richard, additional, Louisias, Margee, additional, Macginnitie, Andrew J., additional, Maciag, Michelle C., additional, O’Neill, Allison, additional, Pepper, Amber N., additional, Permaul, Perdita, additional, Pugh, Mya, additional, Queheillalt, Dianna, additional, Saroya, Tarnjot, additional, Sheehan, William, additional, Smith, Catherine, additional, Socolovsky, Carmela, additional, Treffeisen, Else, additional, Trippa, Lorenzo, additional, Tulchinsky, Abigail, additional, Yee, Christina, additional, Carter, Tina, additional, Fu, Jun, additional, Garcia, Vanessa, additional, Hixon, Jenny, additional, Jackson, Carly, additional, Ji, Yuan, additional, Kalhan, Ravi, additional, Kaur, Opinderjit, additional, Li, Grace, additional, Makhija, Melanie M., additional, Maleckar, Spring, additional, Naureckas, Edward T., additional, Peters, Anju T., additional, Press, Valerie, additional, Qureshi, Mehreen, additional, Reyfman, Paul A., additional, Rosenberg, Sharon R., additional, Ryba, Dominika, additional, Sheng, Jianrong, additional, Xu, Ben, additional, Alam, Rafeul, additional, Anderson, Darci, additional, Belimezova, Sonya, additional, Bitzan, Jennifer, additional, Chupp, Geoffrey, additional, Clark, Brian J., additional, Cohn, Lauren, additional, Cruse, Margaret Hope, additional, Estrom, Jean, additional, Freid, Leah, additional, Villalobos, Jose Gomez, additional, Grant, Nicole, additional, Guntur, Vamsi P., additional, Holm, Carole, additional, Kolakowski, Christena, additional, Manka, Laurie A., additional, Miyazawa, Naomi, additional, Pak, Juno, additional, Pruitt, Diana M., additional, Sharma, Sunita, additional, Stevens, Allen D., additional, Thomas, Kisori, additional, Tippin, Brooke, additional, Valente, Karissa, additional, Wainscoat, Cynthia L., additional, White, Michael P., additional, Winnica, Daniel, additional, Ye, Shuyu, additional, Zeitlin, Pamela L., additional, Bach, Julia, additional, Brownell, Joshua, additional, Castro, Lauren, additional, DeLisa, Julie, additional, Fain, Sean B., additional, Fichtinger, Paul S., additional, Floerke, Heather, additional, Gern, James E., additional, Goswamy, Vinay, additional, Grogan, Jenelle, additional, Hasse, Wendy, additional, Kelley, Rick L., additional, Klaus, Danika, additional, LaBedz, Stephanie, additional, Lowell, Paige, additional, Maddox, Andrew, additional, Mathur, Sameer K., additional, McIntyre, Amanda, additional, Norwick, Lourdes M., additional, Nyenhuis, Sharmilee M., additional, O’Brien, Matthew J., additional, Palas, Tina, additional, Pappalardo, Andrea A., additional, Potter, Mark, additional, Ramratnam, Sima K., additional, Rosenberg, Daniel L., additional, Schauberger, Eric M., additional, Schiebler, Mark L., additional, Schraml, Angela, additional, Taki, Mohamed, additional, Tattersall, Matthew C., additional, Torres, Jissell, additional, Wollet, Lori, additional, Abi-Saleh, Simon, additional, Bendy, Lisa, additional, Borish, Larry, additional, Chmiel, James F., additional, Dix, Aska, additional, France, Lisa, additional, Gammell, Rebecca, additional, Gluvna, Adam, additional, Hirth, Brittany, additional, Hu, Bo, additional, Hyser, Elise, additional, Kloepfer, Kirsten M., additional, Koo, Michelle, additional, Krupp, Nadia L., additional, Labadia, Monica, additional, Lawrence, Joy, additional, Logan, Laurie, additional, Marko, Angela, additional, Matuska, Brittany, additional, Murphy, Deborah, additional, Owensby, Rachel, additional, Roesch, Erica A., additional, Sanders, Don B., additional, Sharp, Jackie, additional, Teague, W. Gerald, additional, Veri, Laura, additional, Shifflett, Kristin Wavell, additional, Camiolo, Matt, additional, Collins, Sarah, additional, Demas, Jessa, additional, Elvin, Courtney, additional, Gauthier, Marc C., additional, Ilnicki, Melissa, additional, Ingram, Jenn, additional, Lane, Lisa, additional, Nouraie, Seyed Mehdi, additional, Trudeau, John B., additional, Zhang, Michael, additional, Barry, Jeffrey, additional, Brickner, Howard, additional, Celso, Janelle, additional, Cernelc-Kohan, Matejka, additional, Diaz, Damaris, additional, Du, Ashley, additional, Jain, Sonia, additional, Liu, Neiman, additional, Nazir, Yusife, additional, Ryu, Julie, additional, Vijayanand, Pandurangan, additional, Almario, Rogelio, additional, Baum, Ariana, additional, Brown, Kellen, additional, Chan, Marilynn H., additional, Gale, Barbara, additional, Haczku, Angela, additional, Harper, Richart W., additional, Heromin, Raymond, additional, Kivler, Celeste, additional, Kuhn, Brooks T., additional, Ly, Ngoc P., additional, McCourt, Paula, additional, Orain, Xavier, additional, Plough, Audrey, additional, Ramirez, Karla, additional, Roberts, Ellese, additional, Schivo, Michael, additional, Singapuri, Amisha, additional, Tham, Tina, additional, Tompkins, Daniel, additional, Twitmyer, Patricia Michelle, additional, Vi, Jade, additional, Atha, Jarron, additional, Bedard, Jennifer, additional, Boomer, Jonathan S., additional, Chung, Andrew, additional, Curtis, Vanessa, additional, Hall, Chase S., additional, Hart, Emily, additional, Jackson, Fatima, additional, Kemp, Pamela, additional, Maxwell, Sharli, additional, Messplay, Maggie, additional, Ramirez, Crystal, additional, Thompson, Brynne, additional, Britt, Ashley, additional, Bryan, Hope, additional, Gotman, Nathan M., additional, Jiang, Yue, additional, Kosorok, Michael R., additional, Mauger, David T., additional, Meekins, Kelsey, additional, Mollenhauer, Jeanette K., additional, Moody, Sarah, additional, Ritz, Cheyanne, additional, Schwartz, Stefanie, additional, Thomlinson, Chalmer, additional, and Wilson, Nicole, additional

Published
2022
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12. A case report of iatrogenic cutaneous Kaposi sarcoma due to rituximab therapy for thrombotic thrombocytopenic purpura.

Author

Jerdan, Kimberly, Brownell, Joshua, Chan, Lawrence, Singh, Manu, and Braniecki, Marylee

Subjects
*KAPOSI'S sarcoma, *THROMBOTIC thrombocytopenic purpura, *RITUXIMAB, *TREATMENT effectiveness, *THERAPEUTICS
Abstract

A letter to the editor is presented that is based on the subject of Kaposi sarcoma disease causing angioproliferative tumor where the thrombotic thrombocytopenic purpura (TTP) is treated using rituximab therapy. It also includes a case study of a 52-year-old male who is diagnosed with the disease of thrombotic thrombocytopenic purpura and is treated with the method of therapy, plasma exchange, and corticosteroids.

Published
2017
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