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1,211 results on '"Brown R. S."'

21. Global real-world evidence of sofosbuvir/velpatasvir as simple, effective HCV treatment: Analysis of 5552 patients from 12 cohorts

Author

Mangia, A, Milligan, S, Khalili, M, Fagiuoli, S, Shafran, S, Carrat, F, Ouzan, D, Papatheodoridis, G, Ramji, A, Borgia, S, Wedemeyer, H, Losappio, R, Perez-Hernandez, F, Wick, N, Brown, R, Lampertico, P, Doucette, K, Ntalla, I, Ramroth, H, Mertens, M, Vanstraelen, K, Turnes, J, Mangia A., Milligan S., Khalili M., Fagiuoli S., Shafran S. D., Carrat F., Ouzan D., Papatheodoridis G., Ramji A., Borgia S. M., Wedemeyer H., Losappio R., Perez-Hernandez F., Wick N., Brown R. S., Lampertico P., Doucette K., Ntalla I., Ramroth H., Mertens M., Vanstraelen K., Turnes J., Mangia, A, Milligan, S, Khalili, M, Fagiuoli, S, Shafran, S, Carrat, F, Ouzan, D, Papatheodoridis, G, Ramji, A, Borgia, S, Wedemeyer, H, Losappio, R, Perez-Hernandez, F, Wick, N, Brown, R, Lampertico, P, Doucette, K, Ntalla, I, Ramroth, H, Mertens, M, Vanstraelen, K, Turnes, J, Mangia A., Milligan S., Khalili M., Fagiuoli S., Shafran S. D., Carrat F., Ouzan D., Papatheodoridis G., Ramji A., Borgia S. M., Wedemeyer H., Losappio R., Perez-Hernandez F., Wick N., Brown R. S., Lampertico P., Doucette K., Ntalla I., Ramroth H., Mertens M., Vanstraelen K., and Turnes J.

Abstract

Background and aims: Achieving sustained virological response (SVR; cure) in hepatitis C patients using a simple regimen is key to making elimination by 2030 possible. In the largest real-world analysis to date, the effectiveness of pangenotypic, panfibrotic, single-tablet, sofosbuvir/velpatasvir (SOF/VEL) once-daily for 12 weeks was assessed in 12 clinical real-world cohorts from various geographical areas, settings and treatment practices. Factors affecting risk of not achieving SVR were assessed. Methods: Adults treated with SOF/VEL 400/100 mg, without ribavirin, were included. All HCV patients reaching Week 12 or 24 post-treatment were assessed for SVR12/24. Factors associated with not achieving SVR12/24 for virological reasons were evaluated using logistic regression analysis. Results: Overall, 5552 patients were included: 13.3% treatment-experienced; 20.7% compensated cirrhotic; 30.2% genotype 1; 29.5% genotype 2; 32.9% genotype 3; 4.7% genotype 4; 3.7% HIV coinfection; 13.4% current/former intravenous drug use. Of the 5196 patients evaluated for effectiveness, 98.9% achieved SVR12/24. High SVR12/24 rates occurred in all genotypes including genotype 3 (98.3%; 1649/1677) and in those with compensated cirrhosis (97.9; 1055/1078). Only 55 patients did not achieve SVR12/24 due to a virological reason; the only factor statistically significantly associated with an increased risk of not achieving SVR12/24 was compensated cirrhosis (P =.002). Overall, 6% (332/5552) of patients did not achieve SVR12/24 for non-virological reasons (67% lost to follow-up; 26.5% early treatment discontinuation). Conclusions: In this large cohort, representative of clinical practice, a simple 12-week regimen of SOF/VEL without ribavirin resulted in high SVR12/24 rates in diverse patient populations, even among those with compensated cirrhosis.

Published
2020

27. Billion-fold acceleration of the methanolysis of paraoxon promoted by La(OTf)3 in methanol

Author

Tsang, Josephine S., Neverov, Alexei A., Brown, R. S., Fang, Cindy C., and Haldar, Kasturi; Wandless, Thomas J.

Subjects
Methanol -- Research, Methanol -- Chemical properties, Lanthanum -- Research, Lanthanum -- Chemical properties, Chemistry
Abstract

It has been demonstrated that a methanol solution containing 2 x 10(super -3) M La(OTf)3, at (super s)(Sub s)PH values around neutrality can be used to promote the methanolysis of paraxon with a 10(super 9) -fold acceleration over the base reaction at the (super s)(Sub s)PH. The system seemed to provide the largest reported acceleration for many man-made catalyst capable of promoting the solvolysis of a phosphate triester.

Published
2003

28. Europium ion catalyzed methanolysis of esters at neutral (super)s (sub)s pH and ambient temperature. Catalytic involvement of Eu (super)3+ (CH (sub)3 O (super)-)(CH (sub)3 OH) (sub)x

Author

Neverov, Alexei A., Gibson, Graham, and Brown, R. S.

Subjects
Chemistry, Inorganic -- Research, Catalysis -- Analysis, Europium, Metal ions, Methane, Esters, Hydrogen-ion concentration, Chemistry
Abstract

Research has been conducted on ester methanolysis with Eu (super)3+ which is introduced into (super)s (sub)s pH-controlled buffer solutions. Results demonstrate that this metal ion produces a remarkable catalytic effect on the methanolysis rate.

Published
2003

29. Methanolysis of nitrocefin catalyzed by one and two Zn (super)2+ ions. A simplified model for class B beta-lactamases

Author

Montoya-Pelaez, Pedro J. and Brown, R. S.

Subjects
Chemistry, Inorganic -- Research, Ions -- Physiological aspects, Zinc -- Physiological aspects, Beta lactamases -- Physiological aspects, Methanol -- Physiological aspects, Chemistry
Abstract

Research has been conducted on the nitrocefin. The investigation of its methanolysis in anhydrous methanol has been carried out and the results suggest that this methanolysis has occurred in the active site of Zn (super)2+ (super)- beta-lactamases.

Published
2002

41. La (super)3+ - catalyzed methanolysis of phosphate diesters. Remarkable rate acceleration of the methanolysis of diphenyl phosphate, methyl p-nitrophenyl phosphate, and bis(p-nitrophenyl) phosphate

Author

Neverov, Alexei A. and Brown, R. S.

Subjects
Chemistry, Inorganic -- Research, Lanthanum -- Physiological aspects, Phosphates -- Physiological aspects, Esters -- Physiological aspects, Hydrogen-ion concentration -- Physiological aspects, Methanol -- Physiological aspects, Chemistry
Abstract

Research has been conducted on the La (super)3+. The interactions of this metal ion with methyl p-nitrophenyl phosphate, diphenyl phosphate and bis(p-nitrophenyl) phosphate have been investigated in methanol under homogeneous conditions of (super)S (sub) S pH and the results are presented.

Published
2001

43. Mechanistic evaluation of the halocyclization of 4-penten-1-ol by some bis(2-substituted pyridine) and bis(2,6-disubstituted pyridine)bromonium triflates

Author

Cui, Xi-Lin and Brown, R. S.

Subjects
Chemistry, Organic -- Research, Pyridine -- Physiological aspects, Bromine -- Physiological aspects, Phosphorus -- Physiological aspects, Biological sciences, Chemistry
Abstract

Research has been conducted on the 4-penten-1-ol mediated by bis(2-substituted pyridine) and bis(2,6-disubstituted pyridine)bromonium triflates. The halocyclization reaction of this 4-penten-1-ol has been investigated in determining the effect of the substituents on the reaction mechanism.

Published
2000

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