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1. Kontsevich graphs act on Nambu-Poisson brackets, I. New identities for Jacobian determinants

Author

Kiselev, Arthemy V., Brown, Mollie S. Jagoe, and Schipper, Floor

Subjects
Mathematics - Quantum Algebra, Mathematical Physics, Mathematics - Symplectic Geometry, 53D55, 53D17, 05C22, 17B63, 17B70, 68R10
Abstract

Nambu-determinant brackets on $R^d\ni x=(x^1,...,x^d)$, $\{f,g\}_d(x)=\rho(x) \det(\partial(f,g,a_1,...,a_{d-2})/\partial(x^1,...,x^d))$, with $a_i\in C^\infty(R^d)$ and $\rho\partial_x\in\mathfrak{X}^d(R^d)$, are a class of Poisson structures with (non)linear coefficients, e.g., polynomials of arbitrarily high degree. With good cocycles in the graph complex, Kontsevich associated universal -- for all Poisson bivectors $P$ on affine $R^d_{aff}$ -- elements $\dot{P}=Q^\gamma(P)\in H^2_{P}(R^d_{aff})$ in the Lichnerowicz-Poisson second cohomology groups; we note that known graph cocycles $\gamma$ preserve the Nambu-Poisson class $\{P(\rho,a)\}$, and we express, directly from $\gamma$, the evolution $\dot{\rho}$,$\dot{a}$ that induces $\dot{P}$. Over all $d\geq2$ at once, there is no universal mechanism for the bivector cocycles $Q^\gamma_d$ to be trivial, $Q^\gamma_d=[\![P,\vec{X}^\gamma_d(P)]\!]$, w.r.t. vector fields defined uniformly for all dimensions $d$ by the same graph formula. While over $R^2$, the graph flows $\dot{P} = Q^{\gamma_i}_{2D}(P(\rho))$ for $\gamma\in\{\gamma_3,\gamma_5,\gamma_7,...\}$ are trivialized by vector fields $\vec{X}^{\gamma_i}_{2D}=(dx\wedge dy)^{-1}d_{dR}(Ham^{\gamma_i}(P))$ of peculiar shape, we detect that in $d\geq3$, the 1-vectors from 2D, now with $P(\rho,a_1,...,a_{d-2})$ inside, do not solve the problems $Q^{\gamma_i}_{d\geq3}=[\![P,{\vec{X}^{\gamma_i}_{d\geq3}}(P(\rho,a))]\!]$, yet they do yield good Ansatz where we find solutions $\vec{X}^{\gamma_i}_{d=3,4}(P(\rho,a))$. In the study of the step $d\mapsto d+1$, by adapting the Kontsevich graph calculus to the Nambu-Poisson class of brackets, we discover more identities for the Jacobian determinants within $P(\rho,a)$, i.e. for multivector-valued $GL(d)$-invariants on $R^d_{aff}$., Comment: Plenary talk given by AVK at the international conference on Integrable Systems and Quantum Symmetries (ISQS28) held on 1-5 July 2024 at CVUT Prague, Czech Republic; 13 pages, 1 table; followed by papers II. (arXiv:2409.12555 [math.QA]) and III. (arXiv:2409.15932 [math.QA]) by the same authors

Published
2024
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2. Kontsevich graphs act on Nambu-Poisson brackets, III. Uniqueness aspects

Author

Schipper, Floor, Brown, Mollie S Jagoe, and Kiselev, Arthemy V

Subjects
Mathematics - Quantum Algebra, 53D55, 17B63, 05C22, 68R10, 53D17
Abstract

Kontsevich constructed a map between `good' graph cocycles $\gamma$ and infinitesimal deformations of Poisson bivectors on affine manifolds, that is, Poisson cocycles in the second Lichnerowicz--Poisson cohomology. For the tetrahedral graph cocycle $\gamma_3$ and for the class of Nambu-determinant Poisson bivectors $P$ over $\mathbb{R}^2$, $\mathbb{R}^3$ and $\mathbb{R}^4$, we know the fact of trivialization, $\dot{P}=[[ P, \vec{X}^{\gamma_3}_{\text{dim}}]]$, by using dimension-dependent vector fields $\vec{X}^{\gamma_3}_{\text{dim}}$ expressed by Kontsevich (micro-) graphs. We establish that these trivializing vector fields $\vec{X}^{\gamma_3}_{\text{dim}}$ are unique modulo Hamiltonian vector fields $\vec{X}_{H}=d_P(H)= [[ P, H]]$, where $d_P$ is the Lichnerowicz--Poisson differential and where the Hamiltonians $H$ are also represented by Kontsevich (micro-)graphs. However, we find that the choice of Kontsevich (micro-)graphs to represent the aforementioned multivectors is not unique.

Published
2024
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3. Kontsevich graphs act on Nambu--Poisson brackets, II. The tetrahedral flow is a coboundary in 4D

Author

Brown, Mollie S. Jagoe, Schipper, Floor, and Kiselev, Arthemy V.

Subjects
Mathematics - Quantum Algebra, 53D55, 17B63, 05C22, 68R10, 53D17
Abstract

Kontsevich constructed a map from suitable cocycles in the graph complex to infinitesimal deformations of Poisson bi-vector fields. Under the deformations, the bi-vector fields remain Poisson. We ask, are these deformations trivial, meaning, do they amount to a change of coordinates along a vector field? We examine this question for the tetrahedron, the smallest nontrivial suitable graph cocycle in the Kontsevich graph complex, and for the class of Nambu--Poisson brackets on $\mathbb{R}^d$. Within Kontsevich's graph calculus, we use dimension-specific micro-graphs, in which each vertex represents an ingredient of the Nambu--Poisson bracket. For the tetrahedron, Kontsevich knew that the deformation is trivial for $d = 2$ (1996). In 2020, Buring and the third author found that the deformation is trivial for $d = 3$. Building on these discoveries, we now establish that the deformation is trivial for $d = 4$.

Published
2024
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4. Long-term safety and effectiveness of mRNA-1273 vaccine in adults: COVE trial open-label and booster phases

Author

Baden, Lindsey R., El Sahly, Hana M., Essink, Brandon, Follmann, Dean, Hachigian, Gregory, Strout, Cynthia, Overcash, J. Scott, Doblecki-Lewis, Susanne, Whitaker, Jennifer A., Anderson, Evan J., Neuzil, Kathleen, Corey, Lawrence, Priddy, Frances, Tomassini, Joanne E., Brown, Mollie, Girard, Bethany, Stolman, Dina, Urdaneta, Veronica, Wang, Xiaowei, Deng, Weiping, Zhou, Honghong, Dixit, Avika, Das, Rituparna, and Miller, Jacqueline M.

Published
2024
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5. Evaluation of minimally invasive sampling methods for detecting Avipoxvirus: Hummingbirds as a case example.

Author

Galvin, Aoife N, Pandit, Pranav S, English, Simon G, Quock, Rachel C, Bandivadekar, Ruta R, Colwell, Rita R, Robinson, Barbara W, Ernest, Holly B, Brown, Mollie H, Sehgal, Ravinder NM, and Tell, Lisa A

Subjects
Trochilidae, avian pox, disease ecology, prevalence, virus, Veterinary Sciences
Abstract

Avian pox is a common avian virus that in its cutaneous form can cause characteristic lesions on a bird's dermal surfaces. Detection of avian pox in free-ranging birds historically relied on observations of visual lesions and/or histopathology, both which can underestimate avian pox prevalence. We compared traditional visual observation methods for avian pox with molecular methods that utilize minimally invasive samples (blood, toenail clipping, feathers, and dermal swabs) in an ecologically important group of birds, hummingbirds. Specifically, avian pox prevalence in several species of hummingbirds were examined across multiple locations using three different methods: (1) visual inspection of hummingbirds for pox-like lesions from a long-term banding data set, (2) qPCR assay of samples from hummingbird carcasses from wildlife rehabilitation centers, and (3) qPCR assay of samples from live-caught hummingbirds. A stark difference in prevalences among these three methods was identified, with an avian pox prevalence of 1.5% from banding data, 20.4% from hummingbird carcasses, and 32.5% from live-caught hummingbirds in California. This difference in detection rates underlines the necessity of a molecular method to survey for avian pox, and this study establishes one such method that could be applied to other wild bird species. Across all three methods, Anna's hummingbirds harbored significantly higher avian pox prevalence than other species examined, as did males compared with females and birds caught in Southern California compared with Northern California. After hatch-year hummingbirds also harbored higher avian pox prevalences than hatch-year hummingbirds in the California banding data set and the carcass data set. This is the first study to estimate the prevalence of avian pox in hummingbirds and address the ecology of this hummingbird-specific strain of avian pox virus, providing vital information to inform future studies on this charismatic and ecologically important group of birds.

Published
2022

6. Current state-of-the-art and gaps in platform trials: 10 things you should know, insights from EU-PEARL

Author

Sánchez-Montalva, Adrian, Estevez, Ana Belén, Sánchez, Àlex, Sanjuan, Anna, Sena, Elena, Granados, Emma, Arévalo de Andrés, Esther, Nuñez, Fátima, Arteaga, Gara, Fuentes Ruiz, Gabriela Perez, Fernández, Guillermo, Rivera-Esteban, Jesus, Comella, Joan, Ramos-Quiroga, Josep Antoni, Genescà, Joan, Espinosa, Juan, Pericàs, Juan Manuel, Murcia, Lada, Cash-Gibson, Lucinda, de Valles Silvosa, Maria, Barroso de Sousa, María Fernanda, Sánchez-Maroto Carrizo, Olga, Ibañez-Jiménez, Pol, Augustin, Salvador, Perez-Hoyos, Santiago, Rodríguez-Navarro, Sarai, Muñoz-Martínez, Sergio, Serres, Silvia, Kalko, Susana, Michon, Amelie, Ussi, Anton, Lydall, Ben, van de Ketterij, Edwin, Quiles, Ignacio, Carapina, Tamara, Kumaus, Constantin, Ramazanova, Dariga, Meyer, Elias Laurin, Koenig, Franz, Roig, Marta Bofill, Brunner, Martin, Posch, Martin, Krotka, Pavla, Zehetmayer, Sonja, Carton, Charlotte, Legius, Eric, Begum, Amina, Pariante, Carmine, Worrell, Courtney, Lombardo, Giulia, Sforzini, Luca, Brown, Mollie, Gullet, Nancy, Amasi-Hartoonian, Nare, Ferner, Rosalie, Kose, Melisa, Spitaleri, Andrea, Ghodousi, Arash, Di Serio, Clelia, Cirillo, Daniela, Cugnata, Federica, Saluzzo, Francesca, Benedetti, Francesco, Scarale, Maria Giovanna, Zini, Michela, Rancoita, Paola Maria, Alagna, Riccardo, Poletti, Sara, Dhaenens, Britt, Van Der Lei, Johan, de Steenwinkel, Jurriaan, Moinat, Maxim, Oostenbrink, Rianne, Hoogendijk, Witte, Hölscher, Michael, Heinrich, Norbert, Otte, Christian, Potratz, Cornelia, Zocholl, Dario, Kulakova, Eugenia, Tacke, Frank, Brasanac, Jelena, Leubner, Jonas, Krajewska, Maja, Freitag, Michaela Maria, Gold, Stefan, Zoller, Thomas, Chae, Woo Ri, Daniel, Christel, Kara, Leila, Vaterkowski, Morgan, Griffon, Nicolas, Wolkenstein, Pierre, Pais, Raluca, Ratziu, Vlad, Voets, David, Maes, Christophe, Kalra, Dipak, Thienpoint, Geert, Deckerck, Jens, Lea, Nathan, Singleton, Peter, Viele, Kert, Jacko, Peter, Berry, Scott, Parke, Tom, Aydin, Burç, Kubiak, Christine, Demotes, Jacques, Ueda, Keiko, Matei, Mihaela, Contrino, Sergio, Röhl, Claas, Cordero, Estefania, Greenhalgh, Fiona, Jarke, Hannes, Angelova, Juliana, Boudes, Mathieu, Dressler, Stephan, Strammiello, Valentina, Anstee, Quentin, Gutierrez-Ibarluzea, Iñaki, Otte, Maximilian, Heimbach, Natalie, Hofner, Benjamin, Burgwinkel, Cora, Kaestel, Hue, Hees, Katharina, Nguyen, Quynh, Prieto-Alhambra, Daniel, Tan, Eng Hooi (Cheryl), Raviglione, Mario, de Colombani, Pierpaolo, Villa, Simone, Maron, Eduard, Evans, Gareth, Savitz, Adam J., Van Dessel, Ann, Duca, Anna, Kaminski, Anne, Wouters, Bie, Porter, Brandon, Charron, Catherine, Spiertz, Cecile, Zizzamia, Christopher, Millar, Daniel, Hasselbaink, Danny, Orr, David, Kesters, Divya, Hubin, Ellen, Davies, Emma, Didden, Eva-Maria, Guz, Gabriela, Verstraete, Evelyn, Mao, Gary, Capuano, George, Martynowicz, Heddie, De Smedt, Heidi, Larsson, Ingela, Bruegelmans, Ines, Coste, Isabelle, Gonzalez Moreno, Jesus Maria, Niewczas, Julia, Xu, Jiajun, Rombouts, Karin, Woo, Katherine, Wuyts, Kathleen, Hersh, Kathryn, Oldenburg, Khrista, Zhang, Lingjiao, Schmidt, Mark, Szuch, Mark, Todorovic, Marija, Mangelaars, Maartje, Grewal, Melissa, Sandor, Molli, Di Prospero, Nick, Van Houten, Pamela, Minnick, Pansy, Bastos, Polyana, Patrizi, Robert, Morello, Salvatore, De Wilde, Severijn, Sun, Tao, Kline, Timothy, de Marez, Tine, Mielke, Tobias, Reijns, Tom, Popova, Vanina, Flossbach, Yanina, Tymofyeyev, Yevgen, De Groote, Zeger, Sverdlov, Alex, Bobirca, Alexandra, Krause, Annekatrin, Bobrica, Catalin, Heintz, Daniela, Magirr, Dominic, Glimm, Ekkehard, Baffert, Fabienne, Castiglione, Federica, Caruso, Franca, Patalano, Francesco, Bretz, Frank, Heimann, Guenter, Carbarns, Ian, Rodríguez, Ignacio, Ratescu, Ioana, Hampson, Lisa, Pedrosa, Marcos, Hark, Mareile, Mesenbrink, Peter, Penna, Sabina Hernandez, Bergues-Lang, Sarah, Baltes-Engler, Susanne, Arsiwala, Tasneem, Mondragon, Valeria Jordan, Guo, Hua, Da Costa, Jose Leite, Burman, Carl-Fredrik, Kirk, George, Aaes-Jørgensen, Anders, Dirach, Jorgen, Kjær, Mette Skalshøi, Martin, Alexandra, Hristov, Diyan, Rousseaux, Florent, Hittel, Norbert, Dornheim, Robert, Evans, Daniel, Sykes, Nick, Couvert, Camille, Leuven, Catherine, Notelet, Loïc, Gidh-Jain, Madhavi, Jouannin, Mathieu, Ammour, Nadir, Pierre, Suzanne, Haufe, Volker, Dong, Yingwen, Dubanchet, Catherine, de Préville, Nathalie, Baltauss, Tania, Jian, Zhu, Shnider, Sara, Bar-El, Tal, Bakker, Annette, Nievo, Marco, Iloeje, Uche, Conradie, Almari, Auffarrth, Ece, Lombard, Leandra, Benhayoun, Majda, Olugbosi, Morounfolu, Seidel, Stephanie S., Gumí, Berta, Guzmán, Claudia García, Molero, Eva, Pairó, Gisela, Machin, Núria, Cardelús, Raimon, Ramasastry, Saira, Pelzer, Saskia, Kremer, Andreas, Lindfors, Erno, Lynch, Chris, Spiertz, Cécile, Machín, Núria, and Pericàs, Juan M.

Published
2024
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7. Safety and Immunogenicity of an mRNA-1273 Booster in Children.

Author

Berthaud, Vladimir, Creech, C Buddy, Rostad, Christina A, Carr, Quito, Leon, Liberation de, Dietrich, Monika, Gupta, Anil, Javita, David, Nachman, Sharon, Pinninti, Swetha, Rathore, Mobeen, Rodriguez, Carina A, Luzuriaga, Katherine, Towner, William, Yeakey, Anne, Brown, Mollie, Zhao, Xiaoping, Deng, Weiping, Xu, Wenqin, and Zhou, Honghong

Subjects
IMMUNIZATION, VIRAL antibodies, PATIENT safety, RESEARCH funding, PLACEBOS, IMMUNOGLOBULINS, STATISTICAL sampling, COVID-19 vaccines, RANDOMIZED controlled trials, DESCRIPTIVE statistics, MESSENGER RNA, VACCINE immunogenicity, PUBLIC health, CLINICAL trial registries, COVID-19, CHILDREN
Abstract

Background A 2-dose mRNA-1273 primary series in children aged 6 months–5 years (25 µg) and 6–11 years (50 µg) had an acceptable safety profile and was immunogenic in the phase 2/3 KidCOVE study. We present data from KidCOVE participants who received an mRNA-1273 booster dose. Methods An mRNA-1273 booster dose (10 µg for children aged 6 months–5 years; 25 µg for children aged 6–11 years; age groups based on participant age at enrollment) was administered ≥6 months after primary series completion. The primary safety objective was the safety and reactogenicity of an mRNA-1273 booster dose. The primary immunogenicity objective was to infer efficacy of an mRNA-1273 booster dose by establishing noninferiority of neutralizing antibody (nAb) responses after a booster in children versus nAb responses observed after the mRNA-1273 primary series in young adults (18–25 years) from the pivotal efficacy study. Data were collected from March 2022 to June 2023. Results Overall, 153 (6 months–5 years) and 2519 (6–11 years) participants received an mRNA-1273 booster dose (median age at receipt of booster: 2 and 10 years, respectively). The booster dose safety profile was generally consistent with that of the primary series in children; no new safety concerns were identified. An mRNA-1273 booster dose elicited robust nAb responses against ancestral SARS-CoV-2 among children and met prespecified noninferiority success criteria versus responses observed after the primary series in young adults. Conclusions Safety and immunogenicity data support administration of an mRNA-1273 booster dose in children aged 6 months to 11 years. Clinical Trials Registration NCT04796896 (Clinicaltrials.gov). [ABSTRACT FROM AUTHOR]

Published
2024
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10. Obtaining super-resolved images at the mesoscale through super-resolution radial fluctuations.

Author

Brown, Mollie, Foylan, Shannan, Rooney, Liam M., Gould, Gwyn W., and McConnell, Gail

Subjects
*HIGH resolution imaging, *NUMERICAL apertures, *CELL anatomy, *SPATIAL resolution, *CELL imaging
Abstract

Significance: Current super-resolution imaging techniques allow for a greater understanding of cellular structures; however, they are often complex or only have the ability to image a few cells at once. This small field of view (FOV) may not represent the behavior across the entire sample, and manual selection of regions of interest (ROIs) may introduce bias. It is possible to stitch and tile many small ROIs; however, this can result in artifacts across an image. Aim: The aim is to achieve accurate super-resolved images across a large FOV (4.4 × 3.0 mm). Approach: We have applied super-resolution radial fluctuations processing in conjunction with the Mesolens, which has the unusual combination of a low-magnification and high numerical aperture, to obtain super-resolved images. Results: We demonstrate it is possible to achieve images with a resolution of 446.3 ± 10.9 nm, providing a ~1.6-fold improvement in spatial resolution, over an FOV of 4.4 × 3.0 mm, with minimal error, and consistent structural agreement. Conclusions: We provide a simple method for obtaining accurate super-resolution images over a large FOV, allowing for a simultaneous understanding of both subcellular structures and their large-scale interactions. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Long-term safety and efficacy of COVE study open-label and booster phases

Author

Baden, Lindsey, primary, Sahly, Hana El, additional, Essink, Brandon, additional, Follmann, Dean, additional, Hachigian, Gregory, additional, Strout, Cynthia, additional, Overcash, J. Scott, additional, Doblecki-Lewis, Susanne, additional, Whitaker, Jennifer, additional, Anderson, Evan, additional, Neuzil, Kathleen, additional, Corey, Lawrence, additional, Priddy, Frances, additional, Tomassini, Joanne, additional, Brown, Mollie, additional, Girard, Bethany, additional, Stolman, Dina, additional, Urdaneta, Veronica, additional, Wang, Xiaowei, additional, Deng, Weiping, additional, Zhou, Honghong, additional, Dixit, Avika, additional, Das, Rituparna, additional, and Miller, Jacqueline, additional

Published
2024
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13. Current state-of-the-art and gaps in platform trials: 10 things you should know, insights from EU-PEARL

Author

Koenig, Franz, primary, Spiertz, Cécile, additional, Millar, Daniel, additional, Rodríguez-Navarro, Sarai, additional, Machín, Núria, additional, Van Dessel, Ann, additional, Genescà, Joan, additional, Pericàs, Juan M., additional, Posch, Martin, additional, Sánchez-Montalva, Adrian, additional, Estevez, Ana Belén, additional, Sánchez, Àlex, additional, Sanjuan, Anna, additional, Sena, Elena, additional, Granados, Emma, additional, Arévalo de Andrés, Esther, additional, Nuñez, Fátima, additional, Arteaga, Gara, additional, Fuentes Ruiz, Gabriela Perez, additional, Fernández, Guillermo, additional, Rivera-Esteban, Jesus, additional, Comella, Joan, additional, Ramos-Quiroga, Josep Antoni, additional, Espinosa, Juan, additional, Pericàs, Juan Manuel, additional, Murcia, Lada, additional, Cash-Gibson, Lucinda, additional, de Valles Silvosa, Maria, additional, Barroso de Sousa, María Fernanda, additional, Sánchez-Maroto Carrizo, Olga, additional, Ibañez-Jiménez, Pol, additional, Augustin, Salvador, additional, Perez-Hoyos, Santiago, additional, Muñoz-Martínez, Sergio, additional, Serres, Silvia, additional, Kalko, Susana, additional, Michon, Amelie, additional, Ussi, Anton, additional, Lydall, Ben, additional, van de Ketterij, Edwin, additional, Quiles, Ignacio, additional, Carapina, Tamara, additional, Kumaus, Constantin, additional, Ramazanova, Dariga, additional, Meyer, Elias Laurin, additional, Koenig, Franz, additional, Roig, Marta Bofill, additional, Brunner, Martin, additional, Krotka, Pavla, additional, Zehetmayer, Sonja, additional, Carton, Charlotte, additional, Legius, Eric, additional, Begum, Amina, additional, Pariante, Carmine, additional, Worrell, Courtney, additional, Lombardo, Giulia, additional, Sforzini, Luca, additional, Brown, Mollie, additional, Gullet, Nancy, additional, Amasi-Hartoonian, Nare, additional, Ferner, Rosalie, additional, Kose, Melisa, additional, Spitaleri, Andrea, additional, Ghodousi, Arash, additional, Di Serio, Clelia, additional, Cirillo, Daniela, additional, Cugnata, Federica, additional, Saluzzo, Francesca, additional, Benedetti, Francesco, additional, Scarale, Maria Giovanna, additional, Zini, Michela, additional, Rancoita, Paola Maria, additional, Alagna, Riccardo, additional, Poletti, Sara, additional, Dhaenens, Britt, additional, Van Der Lei, Johan, additional, de Steenwinkel, Jurriaan, additional, Moinat, Maxim, additional, Oostenbrink, Rianne, additional, Hoogendijk, Witte, additional, Hölscher, Michael, additional, Heinrich, Norbert, additional, Otte, Christian, additional, Potratz, Cornelia, additional, Zocholl, Dario, additional, Kulakova, Eugenia, additional, Tacke, Frank, additional, Brasanac, Jelena, additional, Leubner, Jonas, additional, Krajewska, Maja, additional, Freitag, Michaela Maria, additional, Gold, Stefan, additional, Zoller, Thomas, additional, Chae, Woo Ri, additional, Daniel, Christel, additional, Kara, Leila, additional, Vaterkowski, Morgan, additional, Griffon, Nicolas, additional, Wolkenstein, Pierre, additional, Pais, Raluca, additional, Ratziu, Vlad, additional, Voets, David, additional, Maes, Christophe, additional, Kalra, Dipak, additional, Thienpoint, Geert, additional, Deckerck, Jens, additional, Lea, Nathan, additional, Singleton, Peter, additional, Viele, Kert, additional, Jacko, Peter, additional, Berry, Scott, additional, Parke, Tom, additional, Aydin, Burç, additional, Kubiak, Christine, additional, Demotes, Jacques, additional, Ueda, Keiko, additional, Matei, Mihaela, additional, Contrino, Sergio, additional, Röhl, Claas, additional, Cordero, Estefania, additional, Greenhalgh, Fiona, additional, Jarke, Hannes, additional, Angelova, Juliana, additional, Boudes, Mathieu, additional, Dressler, Stephan, additional, Strammiello, Valentina, additional, Anstee, Quentin, additional, Gutierrez-Ibarluzea, Iñaki, additional, Otte, Maximilian, additional, Heimbach, Natalie, additional, Hofner, Benjamin, additional, Burgwinkel, Cora, additional, Kaestel, Hue, additional, Hees, Katharina, additional, Nguyen, Quynh, additional, Prieto-Alhambra, Daniel, additional, Tan, Eng Hooi (Cheryl), additional, Raviglione, Mario, additional, de Colombani, Pierpaolo, additional, Villa, Simone, additional, Maron, Eduard, additional, Evans, Gareth, additional, Savitz, Adam J., additional, Duca, Anna, additional, Kaminski, Anne, additional, Wouters, Bie, additional, Porter, Brandon, additional, Charron, Catherine, additional, Spiertz, Cecile, additional, Zizzamia, Christopher, additional, Hasselbaink, Danny, additional, Orr, David, additional, Kesters, Divya, additional, Hubin, Ellen, additional, Davies, Emma, additional, Didden, Eva-Maria, additional, Guz, Gabriela, additional, Verstraete, Evelyn, additional, Mao, Gary, additional, Capuano, George, additional, Martynowicz, Heddie, additional, De Smedt, Heidi, additional, Larsson, Ingela, additional, Bruegelmans, Ines, additional, Coste, Isabelle, additional, Gonzalez Moreno, Jesus Maria, additional, Niewczas, Julia, additional, Xu, Jiajun, additional, Rombouts, Karin, additional, Woo, Katherine, additional, Wuyts, Kathleen, additional, Hersh, Kathryn, additional, Oldenburg, Khrista, additional, Zhang, Lingjiao, additional, Schmidt, Mark, additional, Szuch, Mark, additional, Todorovic, Marija, additional, Mangelaars, Maartje, additional, Grewal, Melissa, additional, Sandor, Molli, additional, Di Prospero, Nick, additional, Van Houten, Pamela, additional, Minnick, Pansy, additional, Bastos, Polyana, additional, Patrizi, Robert, additional, Morello, Salvatore, additional, De Wilde, Severijn, additional, Sun, Tao, additional, Kline, Timothy, additional, de Marez, Tine, additional, Mielke, Tobias, additional, Reijns, Tom, additional, Popova, Vanina, additional, Flossbach, Yanina, additional, Tymofyeyev, Yevgen, additional, De Groote, Zeger, additional, Sverdlov, Alex, additional, Bobirca, Alexandra, additional, Krause, Annekatrin, additional, Bobrica, Catalin, additional, Heintz, Daniela, additional, Magirr, Dominic, additional, Glimm, Ekkehard, additional, Baffert, Fabienne, additional, Castiglione, Federica, additional, Caruso, Franca, additional, Patalano, Francesco, additional, Bretz, Frank, additional, Heimann, Guenter, additional, Carbarns, Ian, additional, Rodríguez, Ignacio, additional, Ratescu, Ioana, additional, Hampson, Lisa, additional, Pedrosa, Marcos, additional, Hark, Mareile, additional, Mesenbrink, Peter, additional, Penna, Sabina Hernandez, additional, Bergues-Lang, Sarah, additional, Baltes-Engler, Susanne, additional, Arsiwala, Tasneem, additional, Mondragon, Valeria Jordan, additional, Guo, Hua, additional, Da Costa, Jose Leite, additional, Burman, Carl-Fredrik, additional, Kirk, George, additional, Aaes-Jørgensen, Anders, additional, Dirach, Jorgen, additional, Kjær, Mette Skalshøi, additional, Martin, Alexandra, additional, Hristov, Diyan, additional, Rousseaux, Florent, additional, Hittel, Norbert, additional, Dornheim, Robert, additional, Evans, Daniel, additional, Sykes, Nick, additional, Couvert, Camille, additional, Leuven, Catherine, additional, Notelet, Loïc, additional, Gidh-Jain, Madhavi, additional, Jouannin, Mathieu, additional, Ammour, Nadir, additional, Pierre, Suzanne, additional, Haufe, Volker, additional, Dong, Yingwen, additional, Dubanchet, Catherine, additional, de Préville, Nathalie, additional, Baltauss, Tania, additional, Jian, Zhu, additional, Shnider, Sara, additional, Bar-El, Tal, additional, Bakker, Annette, additional, Nievo, Marco, additional, Iloeje, Uche, additional, Conradie, Almari, additional, Auffarrth, Ece, additional, Lombard, Leandra, additional, Benhayoun, Majda, additional, Olugbosi, Morounfolu, additional, Seidel, Stephanie S., additional, Gumí, Berta, additional, Guzmán, Claudia García, additional, Molero, Eva, additional, Pairó, Gisela, additional, Machin, Núria, additional, Cardelús, Raimon, additional, Ramasastry, Saira, additional, Pelzer, Saskia, additional, Kremer, Andreas, additional, Lindfors, Erno, additional, and Lynch, Chris, additional

Published
2024
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14. Electronic health records (EHRs) in clinical research and platform trials: application of the innovative EHR-based methods developed by EU-PEARL

Author

Lombardo, Giulia, primary, Couvert, Camille, additional, Kose, Melisa, additional, Begum, Amina, additional, Spiertz, Cecile, additional, Worrell, Courtney, additional, Hasselbaink, Danny, additional, Didden, Eva-Maria, additional, Sforzini, Luca, additional, Todorovic, Marija, additional, Lewi, Martine, additional, Brown, Mollie, additional, Vaterkowski, Morgan, additional, Gullet, Nancy, additional, Amasi-Hartoonian, Nare, additional, Griffon, Nicolas, additional, Pais, Raluca, additional, Rodriguez Navarro, Sarai, additional, Kremer, Andreas, additional, Maes, Christophe, additional, Hooi Tan, Eng, additional, Moinat, Maxim, additional, Genescà Ferrer, Joan, additional, Pariante, Carmine M., additional, Kalra, Dipak, additional, Ammour, Nadir, additional, and Kalko, Susana, additional

Published
2023
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15. Electronic health records (EHRs) in clinical research and platform trials:Application of the innovative EHR-based methods developed by EU-PEARL

Author

Lombardo, Giulia, Couvert, Camille, Kose, Melisa, Begum, Amina, Spiertz, Cecile, Worrell, Courtney, Hasselbaink, Danny, Didden, Eva Maria, Sforzini, Luca, Todorovic, Marija, Lewi, Martine, Brown, Mollie, Vaterkowski, Morgan, Gullet, Nancy, Amasi-Hartoonian, Nare, Griffon, Nicolas, Pais, Raluca, Rodriguez Navarro, Sarai, Kremer, Andreas, Maes, Christophe, Tan, Eng Hooi, Moinat, Maxim, Ferrer, Joan Genescà, Pariante, Carmine M., Kalra, Dipak, Ammour, Nadir, Kalko, Susana, Lombardo, Giulia, Couvert, Camille, Kose, Melisa, Begum, Amina, Spiertz, Cecile, Worrell, Courtney, Hasselbaink, Danny, Didden, Eva Maria, Sforzini, Luca, Todorovic, Marija, Lewi, Martine, Brown, Mollie, Vaterkowski, Morgan, Gullet, Nancy, Amasi-Hartoonian, Nare, Griffon, Nicolas, Pais, Raluca, Rodriguez Navarro, Sarai, Kremer, Andreas, Maes, Christophe, Tan, Eng Hooi, Moinat, Maxim, Ferrer, Joan Genescà, Pariante, Carmine M., Kalra, Dipak, Ammour, Nadir, and Kalko, Susana

Abstract

Objective: Electronic Health Record (EHR) systems are digital platforms in clinical practice used to collect patients’ clinical information related to their health status and represents a useful storage of real-world data. EHRs have a potential role in research studies, in particular, in platform trials. Platform trials are innovative trial designs including multiple trial arms (conducted simultaneously and/or sequentially) on different treatments under a single master protocol. However, the use of EHRs in research comes with important challenges such as incompleteness of records and the need to translate trial eligibility criteria into interoperable queries. In this paper, we aim to review and to describe our proposed innovative methods to tackle some of the most important challenges identified. This work is part of the Innovative Medicines Initiative (IMI) EU Patient-cEntric clinicAl tRial pLatforms (EU-PEARL) project's work package 3 (WP3), whose objective is to deliver tools and guidance for EHR-based protocol feasibility assessment, clinical site selection, and patient pre-screening in platform trials, investing in the building of a data-driven clinical network framework that can execute these complex innovative designs for which feasibility assessments are critically important. Methods: ISO standards and relevant references informed a readiness survey, producing 354 criteria with corresponding questions selected and harmonised through a 7-round scoring process (0–1) in stakeholder meetings, with 85% of consensus being the threshold of acceptance for a criterium/question. ATLAS cohort definition and Cohort Diagnostics were mainly used to create the trial feasibility eligibility (I/E) criteria as executable interoperable queries. Results: The WP3/EU-PEARL group developed a readiness survey (eSurvey) for an efficient selection of clinical sites with suitable EHRs, consisting of yes-or-no questions, and a

Published
2023

16. The interaction between kynurenine pathway, suicidal ideation and augmentation therapy with minocycline in patients with treatment-resistant depression

Author

Nettis, Maria Antonietta, primary, Lombardo, Giulia, additional, Hastings, Caitlin, additional, Zajkowska, Zuzanna, additional, Mariani, Nicole, additional, Nikkheslat, Naghmeh, additional, Sforzini, Luca, additional, Worrell, Courtney, additional, Begum, Amina, additional, Brown, Mollie, additional, Cleare, Anthony J, additional, Young, Allan H, additional, Pariante, Carmine M, additional, and Mondelli, Valeria, additional

Published
2023
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17. sj-docx-1-jop-10.1177_02698811231173588 – Supplemental material for The interaction between kynurenine pathway, suicidal ideation and augmentation therapy with minocycline in patients with treatment-resistant depression

Author

Nettis, Maria Antonietta, Lombardo, Giulia, Hastings, Caitlin, Zajkowska, Zuzanna, Mariani, Nicole, Nikkheslat, Naghmeh, Sforzini, Luca, Worrell, Courtney, Begum, Amina, Brown, Mollie, Cleare, Anthony J, Young, Allan H, Pariante, Carmine M, and Mondelli, Valeria

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy), 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-1-jop-10.1177_02698811231173588 for The interaction between kynurenine pathway, suicidal ideation and augmentation therapy with minocycline in patients with treatment-resistant depression by Maria Antonietta Nettis, Giulia Lombardo, Caitlin Hastings, Zuzanna Zajkowska, Nicole Mariani, Naghmeh Nikkheslat, Luca Sforzini, Courtney Worrell, Amina Begum, Mollie Brown, Anthony J Cleare, Allan H Young, Carmine M Pariante and Valeria Mondelli in Journal of Psychopharmacology

Published
2023
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18. Differential effects of trauma type severity and depression severity on immune-related mRNA expression in adulthood

Author

Brown, Mollie, primary, Worrell, Courtney, additional, Cattaneo, Annamaria, additional, Ferrari, Clarissa, additional, Turner, Lorinda, additional, Mariani, Nicole, additional, Enache, Daniela, additional, Hastings, Caitlin, additional, Lombardo, Giulia, additional, McLaughlin, Anna P., additional, Nettis, Maria A., additional, Nikkheslat, Naghmeh, additional, Zajkowska, Zuzanna, additional, Sforzini, Luca, additional, Kose, Melisa, additional, Cattane, Nadia, additional, Lopizzo, Nicola, additional, Mazzelli, Monica, additional, Pointon, Linda, additional, Cowen, Philip J., additional, Cavanagh, Jonathan, additional, Harrison, Neil A., additional, Drevets, Wayne C., additional, Mondelli, Valeria, additional, Bullmore, Edward T., additional, and Pariante, Carmine M., additional

Published
2022
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19. Evaluation of minimally invasive sampling methods for detecting Avipoxvirus: Hummingbirds as a case example

Author

Galvin, Aoife N., primary, Pandit, Pranav S., additional, English, Simon G., additional, Quock, Rachel C., additional, Bandivadekar, Ruta R., additional, Colwell, Rita R., additional, Robinson, Barbara W., additional, Ernest, Holly B., additional, Brown, Mollie H., additional, Sehgal, Ravinder N. M., additional, and Tell, Lisa A., additional

Published
2022
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23. A Bit about BYE: An Entrepreneurial Experience.

Author

Brown, Mollie

Abstract

Describes an entrepreneurial workshop experience for African-American high school students at Albany State College (Georgia). Discusses the beginnings of the program, its purpose, and activities during the workshop. Includes participants' and coordinator's comments. Suggests that the experience encourages students' desire to improve their lot in life. (DK)

Published
1991

25. Local history cards for the Woodring family

Author

Woodring, Andrew; Woodring, Anna, 1805-; Woodring, Benjamin, 1825-; Woodring, Ezra, 1832-; Woodring, Frank; Woodring, George M., 1857-; Janney, Jane; Depoy, Lucinda; Woodring, Martha; Woodring, Martha A., 1861-; Brown, Mollie, 1855-; Woodring, Noah, 1833-; Woodring, Philip; Woodring, Philip W., 1805-; Woodring, Rhoda, 1836-; Woodring, Richard, 1875-; Woodring, Silva, 1873-; Woodwring, Valentine, 1828-; Woodring, Valentine, 1848-; Woodring, William, 1830, Bennett, Elaine C., Woodring, Andrew; Woodring, Anna, 1805-; Woodring, Benjamin, 1825-; Woodring, Ezra, 1832-; Woodring, Frank; Woodring, George M., 1857-; Janney, Jane; Depoy, Lucinda; Woodring, Martha; Woodring, Martha A., 1861-; Brown, Mollie, 1855-; Woodring, Noah, 1833-; Woodring, Philip; Woodring, Philip W., 1805-; Woodring, Rhoda, 1836-; Woodring, Richard, 1875-; Woodring, Silva, 1873-; Woodwring, Valentine, 1828-; Woodring, Valentine, 1848-; Woodring, William, 1830, and Bennett, Elaine C.

Abstract

This archival material has been provided for educational purposes. Ball State University Libraries recognizes that some historic items may include offensive content. Our statement regarding objectionable content is available at: https://dmr.bsu.edu/digital/about

26. Local history cards for the Brown family

Author

Brown, Absalom, 1841-; Brown, Andrew; Brown, Andrew, 1832-; Brown, Andrew, 1834-; Brown, Anna, -1855; Brown, Arch; Brown, B. A.; Brown, Benjamin, 1819-; Brown, Benjamin; Brown, Caroline; Brown, Catherine, 1828-1886; Brown, Charles; Brown, Charles, 1827-; Brown, Charles C.; Brown, Cora Eddie; Brown, David; Brown, David S.; Brown, David, 1826-; Brown, Eddie; Brown, Eliza Jane; Brown, Eliza; Brown, Elizabeth, 1803-; Brown, Elizabeth; Brown, Emeline; Brown, Emaline, 1845-; Brown, Esther; Brown, Frank A.; Brown, Frank M.; Brown, Garret; Brown, George, 1825-; Brown, George A., 1852-; Brown, George W., 1861-; Brown, H.; Brown, Hannah, 1832-; Brown, Harvey, 1849-; Brown, Harvey, 1860-; Brown, Henry, 1857-; Brown, Henry; Brown, Henry, 1798-; Brown, Hugh; Brown, Isaac; Brown, James Washington; Brown, James, 1862-; Brown, James H.; Brown, Jeremiah, -1875; Brown, Jerry, -1875; Brown, Joel, 1818-; Brown, John; Brown, John B.; Brown, John D.; Brown, John C.; Brown, John A., 1831-; Brown, John, 1857-; Brown, Jonathan, 1823-; Brown, Joseph; Brown, Joseph S., 1819-; Brown, Joseph, 1843-; Brown, Joshua, 1838-; Brown, Manda L., 1878-; Brown, Louisa; Brown, Mary; Brown, Mary J., 1846-; Brown, Millie; Brown, Mollie, 1855-; Brown, Nancy; Brown, Nancy, 1815-; Brown, Nathan; Brown, Polly; Brown, Rebecca Leona; Brown, Richard, 1875-; Brown, Samuel; Brown, Samuel, 1797-; Brown, Samuel, 1800-; Brown, Samuel, 1829-; Brown, Sarah Jane; Brown, Sarah, 1829-; Brown, Sarah Catherine; Brown, Silva, 1873-; Brown, Susan; Brown, Thomas, 1799-1871; Brown, Thomas, 1820-; Brown, Thomas; Brown, W. W.; Brown, William; Brown, William, 1855-; Brown, William H., 1846-; Brown, William Henry; Brown, Washington, 1811-; Brown, William, 1823-; Brown, William, 1822-; Brown, William, 1831-; Brown, William R., 1832-; Brown, W. M.; Brown, William, 1810, Bennett, Elaine C., Brown, Absalom, 1841-; Brown, Andrew; Brown, Andrew, 1832-; Brown, Andrew, 1834-; Brown, Anna, -1855; Brown, Arch; Brown, B. A.; Brown, Benjamin, 1819-; Brown, Benjamin; Brown, Caroline; Brown, Catherine, 1828-1886; Brown, Charles; Brown, Charles, 1827-; Brown, Charles C.; Brown, Cora Eddie; Brown, David; Brown, David S.; Brown, David, 1826-; Brown, Eddie; Brown, Eliza Jane; Brown, Eliza; Brown, Elizabeth, 1803-; Brown, Elizabeth; Brown, Emeline; Brown, Emaline, 1845-; Brown, Esther; Brown, Frank A.; Brown, Frank M.; Brown, Garret; Brown, George, 1825-; Brown, George A., 1852-; Brown, George W., 1861-; Brown, H.; Brown, Hannah, 1832-; Brown, Harvey, 1849-; Brown, Harvey, 1860-; Brown, Henry, 1857-; Brown, Henry; Brown, Henry, 1798-; Brown, Hugh; Brown, Isaac; Brown, James Washington; Brown, James, 1862-; Brown, James H.; Brown, Jeremiah, -1875; Brown, Jerry, -1875; Brown, Joel, 1818-; Brown, John; Brown, John B.; Brown, John D.; Brown, John C.; Brown, John A., 1831-; Brown, John, 1857-; Brown, Jonathan, 1823-; Brown, Joseph; Brown, Joseph S., 1819-; Brown, Joseph, 1843-; Brown, Joshua, 1838-; Brown, Manda L., 1878-; Brown, Louisa; Brown, Mary; Brown, Mary J., 1846-; Brown, Millie; Brown, Mollie, 1855-; Brown, Nancy; Brown, Nancy, 1815-; Brown, Nathan; Brown, Polly; Brown, Rebecca Leona; Brown, Richard, 1875-; Brown, Samuel; Brown, Samuel, 1797-; Brown, Samuel, 1800-; Brown, Samuel, 1829-; Brown, Sarah Jane; Brown, Sarah, 1829-; Brown, Sarah Catherine; Brown, Silva, 1873-; Brown, Susan; Brown, Thomas, 1799-1871; Brown, Thomas, 1820-; Brown, Thomas; Brown, W. W.; Brown, William; Brown, William, 1855-; Brown, William H., 1846-; Brown, William Henry; Brown, Washington, 1811-; Brown, William, 1823-; Brown, William, 1822-; Brown, William, 1831-; Brown, William R., 1832-; Brown, W. M.; Brown, William, 1810, and Bennett, Elaine C.

Abstract

This archival material has been provided for educational purposes. Ball State University Libraries recognizes that some historic items may include offensive content. Our statement regarding objectionable content is available at: https://dmr.bsu.edu/digital/about

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