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4 results on '"Brown, Kylie J."'

1. Synthesis of gemcitabine and it's tetrafluorinated analogues

Author

Brown, Kylie J. and Linclau, Bruno

Subjects
547.02, QD Chemistry
Abstract

A novel synthesis of the 2-deoxy-2,2-difluorocytidine nucleoside analogue gemcitabine has been achieved. Starting from the known 3,5-O-dibenzoyl-2- deoxy-2,2-difluororibose, the nucleobase moiety is constructed in a linear fashion, using amino- or urea glycosylation methodology. This methodology has also been employed to synthesise nucleosides containing a tetrafluorinated ribose sugar and has been compared to conventional convergent nucleobase introduction methods. In this respect, a high-yielding Mitsunobu-based protocol has also been developed. Both purine and pyrimidine analogues have been synthesised. The aminoglycosylation methodology has been investigated with a range of amines. The methodology proves high-yielding for primary amines and lesshindered secondary amines. In contrast to expectations, their stability in acidic media was not very high. Anomerisation and ring isomerisation studies have been conducted.

Published
2011

2. Synthesis of gemcitabine and it's tetrafluorinated analogues

Author

Brown, Kylie J.. and Brown, Kylie J..

Abstract

A novel synthesis of the 2-deoxy-2,2-difluorocytidine nucleoside analogue gemcitabine has been achieved. Starting from the known 3,5-O-dibenzoyl-2- deoxy-2,2-difluororibose, the nucleobase moiety is constructed in a linear fashion, using amino- or urea glycosylation methodology. This methodology has also been employed to synthesise nucleosides containing a tetrafluorinated ribose sugar and has been compared to conventional convergent nucleobase introduction methods. In this respect, a high-yielding Mitsunobu-based protocol has also been developed. Both purine and pyrimidine analogues have been synthesised. The aminoglycosylation methodology has been investigated with a range of amines. The methodology proves high-yielding for primary amines and lesshindered secondary amines. In contrast to expectations, their stability in acidic media was not very high. Anomerisation and ring isomerisation studies have been conducted

Published
2011

4. The Constitutionality of Warrantless Cell Phone Searches Incident to Arrest.

Author

Brown, Kylie J. and Bast, Carol M.

Abstract

As technology has developed, Americans have come to carry their most private information with them in digital form on their cell phones. A cell phone has immense storage capacity and can contain a wide variety of communicative information about its owner. In the past, there had been a disagreement among the lower courts as to whether arresting police officers could search the contents of an arrestee’s cell phone. The United States Supreme Court settled this disagreement in Riley v. California-, in that case, the Court held that the warrantless search of a cell phone incident to arrest violated the Fourth Amendment to the United States Constitution. This article discusses case law that preceded Riley v. California, that decision, and its possible ramifications. [ABSTRACT FROM AUTHOR]

Published
2016

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