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Objective: Despite exome sequencing (ES) becoming increasingly incorporated into the prenatal setting, few studies have elucidated motivations for and trust in ES and genomic research among a diverse cohort of patients and their partners. Methods: This is a qualitative study that involved semi‐structured interviews with pregnant or recently pregnant individuals and their partners, interviewed separately, in the setting of ES performed through research for a fetal structural anomaly. All interview transcripts were coded thematically and developed by a multidisciplinary team. Results: Thirty‐five individuals participated, the majority of whom (66%) self‐identified as a racial or ethnic group underrepresented in genomic research. Many patients and their partners expressed trust in the healthcare system and research process and appreciated the extensive testing for information and closure. There were nonetheless concerns about data privacy and protection for individuals, including those underrepresented, who participated in genomic testing and studies. Conclusion: Our findings illustrate important elements of motivation, trust and concern related to prenatal ES performed in the research setting, taking into account the perspectives not only of diverse and underrepresented study participants but also partners of pregnant individuals. Key points: What's already known about this topic? Prenatal exome sequencing is increasingly utilized, yet little is known about motivations for and trust in this testing, particularly from patients underrepresented in genomic research. What does this study add? This study adds perspectives from diverse patients and partners regarding trust in prenatal exome sequencing.Participants expressed trust in healthcare and research, and recognized the utility of testing for information and closure. However, concerns have been raised about data privacy and protection for individuals of underrepresented races and ethnicities. [ABSTRACT FROM AUTHOR]

During summer 2010, national surveillance activities detected Aedes aegypti mosquitoes in 2 tire yards in the Netherlands (1,2). Ae. aegypti mosquitoes are the principal worldwide vectors of dengue and yellow [...]

Background: Public health palliative care interventions are increasingly implemented, with growing recognition of the importance of building evidence to support their utility in end-of-life care. Previous efforts have focused on community outcomes. Aim: To examine the impact of public health palliative care on patterns of health service use at the end of life (primary) and explore which outcomes are being measured within this field of research (secondary). Design: Systematic review of studies reporting qualitative and quantitative data, analysed with a narrative synthesis method. Data sources: A systematic review conducted and reported according to the Preferred Reporting Items for Systematic Reviews and Meta Analyses guideline was undertaken using six electronic databases (MEDLINE, CINAHL, EMBASE, PsycINFO, INFORMIT and COCHRANE) up to February 2020. Results: Searches yielded 2622 unique titles screened for eligibility, resulting in 35 studies measuring outcomes from a public health palliative care approach. Five (14%) studies assessed health system outcomes, and three reported some mixed evidence of impact, including reduced hospital emergency admissions, hospital bed days, hospital costs and increased home deaths. Most studies (86%) instead reported on conceptual (49%), knowledge (40%), programme participation (37%) and/or individual health outcomes (29%). Conclusion: The impact of public health palliative care is an evolving area of empirical inquiry with currently only limited evidence that it improves healthcare utilisation outcomes at the end of life, and limited focus on measurement of these outcomes. Further empirical studies are needed to support the reorientation of health services, which remains an important component in realising 'whole of system change' to bring about quality end-of-life care for all. [ABSTRACT FROM AUTHOR]