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5. A Nutrient-Wide Association Study on Blood Pressure

Author

Tzoulaki, Ioanna, Patel, Chirag J, Okamura, Tomonori, Chan, Queenie, Brown, Ian J, Miura, Katsuyuki, Ueshima, Hirotsugu, Zhao, Liancheng, Van Horn, Linda, Daviglus, Martha L, Stamler, Jeremiah, Butte, Atul J, Ioannidis, John PA, and Elliott, Paul

Subjects
Biomedical and Clinical Sciences, Epidemiology, Public Health, Health Sciences, Nutrition and Dietetics, Nutrition, Prevention, Cardiovascular, Adult, Alcohol Drinking, Biomarkers, Blood Pressure, Cohort Studies, Cross-Sectional Studies, Energy Intake, Female, Humans, Male, Micronutrients, Middle Aged, Nutrition Surveys, Nutritional Status, Potassium, Dietary, Sodium, Dietary, Vitamin B Complex, blood pressure, diet, epidemiology, nutrition assessment, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Public Health and Health Services, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences, Sports science and exercise
Abstract

BackgroundA nutrient-wide approach may be useful to comprehensively test and validate associations between nutrients (derived from foods and supplements) and blood pressure (BP) in an unbiased manner.Methods and resultsData from 4680 participants aged 40 to 59 years in the cross-sectional International Study of Macro/Micronutrients and Blood Pressure (INTERMAP) were stratified randomly into training and testing sets. US National Health and Nutrition Examination Survey (NHANES) four cross-sectional cohorts (1999-2000, 2001-2002, 2003-2004, 2005-2006) were used for external validation. We performed multiple linear regression analyses associating each of 82 nutrients and 3 urine electrolytes with systolic and diastolic BP in the INTERMAP training set. Significant findings were validated in the INTERMAP testing set and further in the NHANES cohorts (false discovery rate

Published
2012

6. Sources, Composition, and Export of Particulate Organic Matter Across British Estuaries

Author

García‐Martín, E. Elena, primary, Sanders, Richard, additional, Evans, Chris D., additional, Kitidis, Vassilis, additional, Lapworth, Dan J., additional, Spears, Bryan M., additional, Tye, Andy, additional, Williamson, Jennifer L., additional, Balfour, Chris, additional, Best, Mike, additional, Bowes, Michael, additional, Breimann, Sarah, additional, Brown, Ian J., additional, Burden, Annette, additional, Callaghan, Nathan, additional, Dise, Nancy B., additional, Farr, Gareth, additional, Felgate, Stacey L., additional, Fishwick, James, additional, Fraser, Mike, additional, Gibb, Stuart, additional, Gilbert, Pete J., additional, Godsell, Nina, additional, Gomez‐Castillo, Africa P., additional, Hargreaves, Geoff, additional, Harris, Carolyn, additional, Jones, Oban, additional, Kennedy, Paul, additional, Lichtschlag, Anna, additional, Martin, Adrian P., additional, May, Rebecca, additional, Mawji, Edward, additional, Mounteney, Ian, additional, Nightingale, Philip D., additional, Olszewska, Justyna P., additional, Painter, Stuart C., additional, Pearce, Christopher R., additional, Pereira, M. Glória, additional, Peel, Kate, additional, Pickard, Amy, additional, Stephens, John A., additional, Stinchcombe, Mark, additional, Thornton, Barry, additional, Woodward, E. Malcolm S., additional, Yarrow, Deborah, additional, and Mayor, Daniel J., additional

Published
2023
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13. Contrasting Estuarine Processing of Dissolved Organic Matter Derived From Natural and Human‐Impacted Landscapes

Author

García‐Martín, E. Elena, primary, Sanders, Richard, additional, Evans, Chris D., additional, Kitidis, Vassilis, additional, Lapworth, Dan J., additional, Rees, Andrew P., additional, Spears, Bryan M., additional, Tye, Andy, additional, Williamson, Jennifer L., additional, Balfour, Chris, additional, Best, Mike, additional, Bowes, Michael, additional, Breimann, Sarah, additional, Brown, Ian J., additional, Burden, Annette, additional, Callaghan, Nathan, additional, Felgate, Stacey L., additional, Fishwick, James, additional, Fraser, Mike, additional, Gibb, Stuart W., additional, Gilbert, Pete J., additional, Godsell, Nina, additional, Gomez‐Castillo, Africa P., additional, Hargreaves, Geoff, additional, Jones, Oban, additional, Kennedy, Paul, additional, Lichtschlag, Anna, additional, Martin, Adrian, additional, May, Rebecca, additional, Mawji, Edward, additional, Mounteney, Ian, additional, Nightingale, Philip D., additional, Olszewska, Justyna P., additional, Painter, Stuart C., additional, Pearce, Christopher R., additional, Pereira, M. Glória, additional, Peel, Kate, additional, Pickard, Amy, additional, Stephens, John A., additional, Stinchcombe, Mark, additional, Williams, Peter, additional, Woodward, E. Malcolm S., additional, Yarrow, Deborah, additional, and Mayor, Daniel J., additional

Published
2021
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17. Genetic loci associated with C-reactive protein levels and risk of coronary heart disease

Author

Elliott, Paul, Chambers, John C., Zhang, Weihua, Clarke, Robert, Hopewell, Jemma C., Peden, John F., Erdmann, Jeanette, Braund, Peter, Engert, James C., Bennett, Derrick, Coin, Lachlan, Ashby, Deborah, Tzoulaki, Ioanna, Brown, Ian J., Mt-Isa, Shahrul, McCarthy, Mark I., Peltonen, Leena, Freimer, Nelson B., Farrall, Martin, Ruokonen, Aima, Hamsten, Anders, Lim, Noha, Froguel, Philippe, Waterworth, Dawn M., Vollenweider, Peter, Waeber, Gerard, Jarvelin, Marjo-Riitta, Mooser,Vincent, Scott, James, Hall, Alistair S., Schunkert, Heribert, Anand, Sonia S., Collins, Rory, Samani, Nilesh J., Watkins, Hugh, and Kooner, Jaspal S.

Subjects
C-reactive protein -- Health aspects, Coronary heart disease -- Causes of, Coronary heart disease -- Risk factors
Abstract

A study was conducted to evaluate the association of loci with the C-reactive protein (CRP) levels and an increased risk of coronary heart disease. Results indicated that a causal relationship did exist between CRP and coronary heart disease.

Published
2009

18. Human metabolic phenotype diversity and its association with diet and blood pressure

Author

Holmes, Elaine, Loo, Ruey Leng, Stamler, Jeremiah, Bictash, Magda, Yap, Ivan K.S., Chan, Queenie, Ebbels, Tim, De Iorio, Maria, Brown, Ian J., Veselkov, Kirill A., Daviglus, Martha L., Kesteloot, Hugo, Ueshima, Hirotsugu, Zhao, Liancheng, Nicholson, Jeremy K., and Elliott, Paul

Subjects
Blood pressure -- Physiological aspects -- Research, Diet -- Physiological aspects -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation, Physiological aspects, Research
Abstract

Metabolic phenotypes are the products of interactions among a variety of factors--dietary, other lifestyle/environmental, gut microbial and genetic (1-3). We use a large-scale exploratory analytical approach to investigate metabolic phenotype [...]

Published
2008

24. The use of low-temperature thermal expansion for the detection of paramagnetic ions in dielectrics

Author

Brown, Ian J.

Subjects
530.41, Solid-state physics
Abstract

The object of the thesis is to demonstrate the existence of Schottky type anomalies in the low temperature thermal expansion of dielectric crystals produced by the presence of a small concentration of strongly coupled paramagnetic impurity ions. Cryogenic equipment, utilising a three terminal capacitance dilatometer, for the semi-automatic measurement of thermal expansion at low temperatures using a dynamic measurement technique has been designed, constructed and commissioned. The results of application of this apparatus to determine the contribution to the thermal expansion at low temperatures of aluminium oxide (Al2O3) due to small concentrations of strongly coupled paramagnetic ions (Cr2+(3d4, 5D), Mn3+(3d4, 5D), v3+ (3d2 , 3F)) is presented. Peaked anomalies in the thermal expansion of Al2O3 doped with these ions have been observed which are not present for undoped samples. The effects observed are in contrast with those predicted using a static crystal field model but may be interpreted in terms of a dynamic Jahn-Teller model.

Published
1982

26. Insights from year-long measurements of air–water CH4 and CO2 exchange in a coastal environment

Author

Yang, Mingxi, Bell, Thomas G., Brown, Ian J., Fishwick, James R., Kitidis, Vassilis, Nightingale, Philip D., Rees, Andrew P., and Smyth, Timothy J.

Abstract

Air–water CH4 and CO2 fluxes were directly measured using the eddy covariance technique at the Penlee Point Atmospheric Observatory on the southwest coast of the United Kingdom from September 2015 to August 2016. The high-frequency, year-long measurements provide unprecedented detail on the variability of these greenhouse gas fluxes from seasonal to diurnal and to semi-diurnal (tidal) timescales. Depending on the wind sector, fluxes measured at this site are indicative of air–water exchange in coastal seas as well as in an outer estuary. For the open-water sector when winds were off the Atlantic Ocean, CH4 flux was almost always positive (annual mean of ∼0.05 mmol m−2 d−1) except in December and January, when CH4 flux was near zero. At times of high rainfall and river flow rate, CH4 emission from the estuarine-influenced Plymouth Sound sector was several times higher than emission from the open-water sector. The implied CH4 saturation (derived from the measured fluxes and a wind-speed-dependent gas transfer velocity parameterization) of over 1000 % in the Plymouth Sound is within range of in situ dissolved CH4 measurements near the mouth of the river Tamar. CO2 flux from the open-water sector was generally from sea to air in autumn and winter and from air to sea in late spring and summer, with an annual mean flux of near zero. A diurnal signal in CO2 flux and implied partial pressure of CO2 in water (pCO2) are clearly observed for the Plymouth Sound sector and also evident for the open-water sector during biologically productive periods. These observations suggest that coastal CO2 efflux may be underestimated if sampling strategies are limited to daytime only. Combining the flux data with seawater pCO2 measurements made in situ within the flux footprint allows us to estimate the CO2 transfer velocity. The gas transfer velocity and wind speed relationship at this coastal location agrees reasonably well with previous open-water parameterizations in the mean but demonstrates considerable variability. We discuss the influences of biological productivity, bottom-driven turbulence and rainfall on coastal air–water gas exchange.

Published
2019

27. Dehydrating and Sterilizing Wastes Using Supercritical CO2

Author

Brown, Ian J

Subjects
Man/System Technology And Life Support
Abstract

A relatively low-temperature process for dehydrating and sterilizing biohazardous wastes in an enclosed life-support system exploits (1) the superior mass-transport properties of supercritical fluids in general and (2) the demonstrated sterilizing property of supercritical CO2 in particular. The wastes to be treated are placed in a chamber. Liquid CO2, drawn from storage at a pressure of 850 psi (approx.=5.9 MPa) and temperature of 0 C, is compressed to pressure of 2 kpsi (approx.=14 MPa) and made to flow into the chamber. The compression raises the temperature to 10 C. The chamber and its contents are then further heated to 40 C, putting the CO2 into a supercritical state, in which it kills microorganisms in the chamber. Carrying dissolved water, the CO2 leaves the chamber through a back-pressure regulator, through which it is expanded back to the storage pressure. The expanded CO2 is refrigerated to extract the dissolved water as ice, and is then returned to the storage tank at 0 C

Published
2006

33. Insights from year-long measurements of air-water CH4 and CO2 exchange in a coastal environment.

Author

Mingxi Yang, Bell, Thomas G., Brown, Ian J., Fishwick, James R., Kitidis, Vassilis, Nightingale, Philip D., Rees, Andrew P., and Smyth, Timothy J.

Subjects
AIR-water interfaces, COASTAL ecosystem health, CARBON dioxide mitigation, GREENHOUSE gas mitigation, BIOLOGICAL productivity, METHANE derivatives
Abstract

Air-water CH4 and CO2 fluxes were directly measured using the eddy covariance technique at the Penlee Point Atmospheric Observatory on the southwest coast of the United Kingdom from September 2015 to August 2016. The high frequency, year-long measurements provide unprecedented detail into the variability of these Greenhouse Gas fluxes from seasonal to diurnal and to semi-diurnal timescales. Depending on the wind sector, fluxes measured at this site are indicative of air-water exchange in coastal seas as well as in an outer estuary. For the open water sector when winds were off the Atlantic Ocean, annual CH4 emission averaged ~ 0.05 mmol m-2 d-1. Open water CH4 flux was near zero in December and January, probably due to reduced biological production of CH4. At times of high rainfall and river flow rate, CH4 emission from the estuarine-influenced Plymouth Sound sector was several times higher than emission from the open water sector. The implied CH4 saturation, derived from the measured fluxes and a wind speed dependent gas transfer velocity parameterization, of over 1000% in the Plymouth Sound is within range of in situ dissolved CH4 measurements near the mouth of the river Tamar. CO2 flux from the open water sector was generally from sea-to-air in autumn and winter and from air-to-sea in late spring and summer, with an annual mean flux of near zero. CO2 flux from the Plymouth Sound sector was more positive, consistent with a higher dissolved CO2 concentration in the estuarine waters. A diurnal signal in CO2 flux and implied dissolved pCO2 are clearly observed for the Plymouth Sound sector and also evident for the open water sector during biologically productive periods. These observations suggest that coastal CO2 efflux may be underestimated if the sampling strategy is limited to daytime only. Combining the fluxes with in situ dissolved pCO2 measurements within the flux footprints allows us to estimate the CO2 transfer velocity. The gas transfer velocity vs. wind speed relationship at this coastal location agrees reasonably well with previous open water parameterizations in the mean, but demonstrates considerable variability. We discuss the influences of biological productivity and bottom-driven turbulence on coastal air-water gas exchange. [ABSTRACT FROM AUTHOR]

Published
2018
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37. Metabolic phenotyping in epidemiology and metabolome-wide association studies

Author

Bictash, Magda, Ebbels, Timothy, Chan, Queenie, Loo, Ruey Leng, Yap, Ivan, Brown, Ian J, De Iorio, Maria, Daviglus, Martha, Holmes, Elaine, Stamler, Jeremiah, Nicholson, Jeremy K., and Elliott, Paul

Subjects
Molecular Epidemiology, Phenotype, Metabolome, Humans, Metabolomics, Reproducibility of Results, Risk Assessment, Article, Biomarkers
Abstract

Metabolic phenotyping of humans allows information to be captured on the interactions between dietary, xenobiotic, other lifestyle and environmental exposures, and genetic variation, which together influence the balance between health and disease risks at both individual and population levels.We describe here the main procedures in large-scale metabolic phenotyping and their application to metabolome-wide association (MWA) studies.By use of high-throughput technologies and advanced spectroscopic methods, application of metabolic profiling to large-scale epidemiologic sample collections, including metabolome-wide association (MWA) studies for biomarker discovery and identification.Metabolic profiling at epidemiologic scale requires optimization of experimental protocol to maximize reproducibility, sensitivity, and quantitative reliability, and to reduce analytical drift. Customized multivariate statistical modeling approaches are needed for effective data visualization and biomarker discovery with control for false-positive associations since 100s or 1,000s of complex metabolic spectra are being processed.Metabolic profiling is an exciting addition to the armamentarium of the epidemiologist for the discovery of new disease-risk biomarkers and diagnostics, and to provide novel insights into etiology, biological mechanisms, and pathways.

Published
2010

38. Individual efforts to reduce salt intake in China, Japan, UK, USA

Author

Okuda, Nagako, primary, Stamler, Jeremiah, additional, Brown, Ian J., additional, Ueshima, Hirotsugu, additional, Miura, Katsuyuki, additional, Okayama, Akira, additional, Saitoh, Shigeyuki, additional, Nakagawa, Hideaki, additional, Sakata, Kiyomi, additional, Yoshita, Katsushi, additional, Zhao, Liancheng, additional, and Elliott, Paul, additional

Published
2014
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39. Blood Pressure Differences Associated With Optimal Macronutrient Intake Trial for Heart Health (OMNIHEART)–Like Diet Compared With a Typical American Diet

Author

Molitor, John, primary, Brown, Ian J., additional, Chan, Queenie, additional, Papathomas, Michail, additional, Liverani, Silvia, additional, Molitor, NuooTing, additional, Richardson, Sylvia, additional, Van Horn, Linda, additional, Daviglus, Martha L., additional, Dyer, Alan, additional, Stamler, Jeremiah, additional, and Elliott, Paul, additional

Published
2014
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40. Glutamic Acid – the Main Dietary Amino Acid – and Blood Pressure: The INTERMAP Study

Author

Stamler, Jeremiah, Brown, Ian J, Daviglus, Martha L, Chan, Queenie, Kesteloot, Hugo, Ueshima, Hirotsugu, Zhao, Liancheng, and Elliott, Paul

Subjects
Adult, Male, Internationality, Glutamic Acid, Blood Pressure, Middle Aged, Article, Cross-Sectional Studies, Hypertension, Humans, Female, Dietary Proteins, Micronutrients, Amino Acids, Cooperative Behavior
Abstract

Data are available that indicate an independent inverse relationship of dietary vegetable protein to the blood pressure (BP) of individuals. Here, we assess whether BP is associated with glutamic acid intake (the predominant dietary amino acid, especially in vegetable protein) and with each of 4 other amino acids that are relatively higher in vegetable than animal protein (proline, phenylalanine, serine, and cystine).This was a cross-sectional epidemiological study with 4680 persons 40 to 59 years of age from 17 random population samples in China, Japan, the United Kingdom, and the United States. BP was measured 8 times at 4 visits; dietary data (83 nutrients, 18 amino acids) were obtained from 4 standardized, multipass, 24-hour dietary recalls and 2 timed 24-hour urine collections. Dietary glutamic acid (percentage of total protein intake) was inversely related to BP. Across multivariate regression models (model 1, which controlled for age, gender, and sample, through model 5, which controlled for 16 possible nonnutrient and nutrient confounders), estimated average BP differences associated with a glutamic acid intake that was higher by 4.72% of total dietary protein (2 SD) were -1.5 to -3.0 mm Hg systolic and -1.0 to -1.6 mm Hg diastolic (z scores -2.15 to -5.11). Results were similar for the glutamic acid-BP relationship with each of the other amino acids also in the model; eg, with control for 15 variables plus proline, systolic/diastolic pressure differences were -2.7/-2.0 mm Hg (z scores -2.51, -2.82). In these 2-amino acid models, higher intake (by 2 SD) of each of the other amino acids was associated with small BP differences and z scores.Dietary glutamic acid may have independent BP-lowering effects, which may contribute to the inverse relation of vegetable protein to BP.

Published
2009

41. Dietary and Urinary Metabonomic Factors Possibly Accounting for Higher Blood Pressure of Black Compared With White Americans

Author

Stamler, Jeremiah, primary, Brown, Ian J., additional, Yap, Ivan K.S., additional, Chan, Queenie, additional, Wijeyesekera, Anisha, additional, Garcia-Perez, Isabel, additional, Chadeau-Hyam, Marc, additional, Ebbels, Timothy M.D., additional, De Iorio, Maria, additional, Posma, Joram, additional, Daviglus, Martha L., additional, Carnethon, Mercedes, additional, Holmes, Elaine, additional, Nicholson, Jeremy K., additional, and Elliott, Paul, additional

Published
2013
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42. Relationship of dietary monounsaturated fatty acids to blood pressure

Author

Miura, Katsuyuki, primary, Stamler, Jeremiah, additional, Brown, Ian J., additional, Ueshima, Hirotsugu, additional, Nakagawa, Hideaki, additional, Sakurai, Masaru, additional, Chan, Queenie, additional, Appel, Lawrence J., additional, Okayama, Akira, additional, Okuda, Nagako, additional, Curb, J. David, additional, Rodriguez, Beatriz L., additional, Robertson, Claire, additional, Zhao, Liancheng, additional, and Elliott, Paul, additional

Published
2013
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43. The inhibition of N2O production by ocean acidification in cold temperate and polar waters.

Author

Rees, Andrew P., Brown, Ian J., Jayakumar, Amal, and Ward, Bess B.

Subjects
*NITROUS oxide, *OCEAN acidification, *COLD (Temperature), *AMMONIA-oxidizing bacteria, *SEA water analysis, *ARCHAEBACTERIA
Abstract

The effects of ocean acidification (OA) on nitrous oxide (N 2 O) production and on the community composition of ammonium oxidizing archaea (AOA) were examined in the northern and southern sub-polar and polar Atlantic Ocean. Two research cruises were performed during June 2012 between the North Sea and Arctic Greenland and Barent Seas, and in January–February 2013 to the Antarctic Scotia Sea. Seven stations were occupied in all during which shipboard experimental manipulations of the carbonate chemistry were performed through additions of NaHCO 3 − +HCl in order to examine the impact of short-term (48 h for N 2 O and between 96 and 168 h for AOA) exposure to control and elevated conditions of OA. During each experiment, triplicate incubations were performed at ambient conditions and at 3 lowered levels of pH which varied between 0.06 and 0.4 units according to the total scale and which were targeted at CO 2 partial pressures of ~500, 750 and 1000 µatm. The AOA assemblage in both Arctic and Antarctic regions was dominated by two major archetypes that represent the marine AOA clades most often detected in seawater. There were no significant changes in AOA assemblage composition between the beginning and end of the incubation experiments. N 2 O production was sensitive to decreasing pH T at all stations and decreased by between 2.4% and 44% with reduced pH T values of between 0.06 and 0.4. The reduction in N 2 O yield from nitrification was directly related to a decrease of between 28% and 67% in available NH 3 as a result of the pH driven shift in the NH 3 :NH 4 + equilibrium. The maximum reduction in N 2 O production at conditions projected for the end of the 21st century was estimated to be 0.82 Tg N y −1 . [ABSTRACT FROM AUTHOR]

Published
2016
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45. 184 RELATION OF RAW AND COOKED VEGETABLE CONSUMPTION TO BLOOD PRESSURE

Author

Chan, Queenie, primary, Stamler, Jeremiah, additional, Brown, Ian J, additional, Griep, Linda M. Oude, additional, Daviglus, Martha L, additional, Van Horn, Linda, additional, Okuda, Nagako, additional, Miura, Katsuyuki, additional, Ueshima, Hirotsugu, additional, Zhao, Liancheng, additional, and Elliott, Paul, additional

Published
2012
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47. 413 A NUTRIENT WIDE ASSOCIATION STUDY ON BLOOD PRESSURE

Author

Elliott, Paul, primary, Tzoulaki, Ioanna, additional, Patel, Chirag, additional, Chan, Queenie, additional, Brown, Ian J., additional, Miura, Katsuyuki, additional, Ueshima, Hirotsugu, additional, Okamura, Tomonori, additional, Zhao, Liancheng, additional, Van Horn, Linda, additional, Daviglus, Martha, additional, Stamler, Jeremiah, additional, Butte, Atul, additional, and Ioannidis, John P.A., additional

Published
2012
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49. Quantitative UPLC-MS/MS analysis of the gut microbial co-metabolites phenylacetylglutamine, 4-cresyl sulphate and hippurate in human urine: INTERMAP Study

Author

Wijeyesekera, Anisha, primary, Clarke, Philip A., additional, Bictash, Magda, additional, Brown, Ian J., additional, Fidock, Mark, additional, Ryckmans, Thomas, additional, Yap, Ivan K. S., additional, Chan, Queenie, additional, Stamler, Jeremiah, additional, Elliott, Paul, additional, Holmes, Elaine, additional, and Nicholson, Jeremy K., additional

Published
2012
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50. Cisco IOS Cookbook

Author

Dooley, Kevin, Brown, Ian J., Dooley, Kevin, and Brown, Ian J.

Subjects
Internetworking (Telecommunication), Routers (Computer networks), Computer network protocols
Abstract

Never has something cried out for a cookbook quite as much as Cisco's Internetwork Operating System (IOS). IOS is powerful and flexible, but also confusing and daunting. Most tasks can be accomplished in several different ways. And you don't want to spend precious time figuring out which way is best when you're trying to solve a problem quickly.That's what this cookbook is for. Fortunately, most router configuration tasks can be broken down into several more or less independent steps: you configure an interface, you configure a routing protocol, you set up backup links, you implement packet filters and other access control mechanisms. What you really need is a set of recipes that show you how to perform the most common tasks, so you can quickly come up with a good configuration for your site. And you need to know that these solutions work: you don't want to find yourself implementing a backup link at 2 A.M. because your main link is down and the backup link you set up when you installed the router wasn't quite right.Thoroughly revised and expanded, Cisco IOS Cookbook, 2nd Edition, adds sections on MPLS, Security, IPv6, and IP Mobility, and presents solutions to the most common configuration problems, including:Configuring interfaces of many types, from serial to ATM and Frame RelayConfiguring all of the common IP routing protocols (RIP, EIGRP, OSPF, and BGP)Configuring authenticationConfiguring other services, including DHCP and NTPSetting up backup links, and using HSRP to configure backup routersManaging the router, including SNMP and other solutionsUsing access lists to control the traffic through the routerIf you work with Cisco routers, you need a book like this to help you solve problems quickly and effectively. Even if you're experienced, the solutions and extensive explanations will give you new ideas and insights into router configuration. And if you're not experienced--if you've just been given responsibility for managing a network with Cisco routers--this book could be a job-saver.

Published
2007

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