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1. Harmonizing the Generation and Pre-publication Stewardship of FAIR Image Data

Author

Bialy, Nikki, Alber, Frank, Andrews, Brenda, Angelo, Michael, Beliveau, Brian, Bintu, Lacramioara, Boettiger, Alistair, Boehm, Ulrike, Brown, Claire M., Maina, Mahmoud Bukar, Chambers, James J., Cimini, Beth A., Eliceiri, Kevin, Errington, Rachel, Faklaris, Orestis, Gaudreault, Nathalie, Germain, Ronald N., Goscinski, Wojtek, Grunwald, David, Halter, Michael, Hanein, Dorit, Hickey, John W., Lacoste, Judith, Laude, Alex, Lundberg, Emma, Ma, Jian, Malacrida, Leonel, Moore, Josh, Nelson, Glyn, Neumann, Elizabeth Kathleen, Nitschke, Roland, Onami, Shuichi, Pimentel, Jaime A., Plant, Anne L., Radtke, Andrea J., Sabata, Bikash, Schapiro, Denis, Schöneberg, Johannes, Spraggins, Jeffrey M., Sudar, Damir, Vierdag, Wouter-Michiel Adrien Maria, Volkmann, Niels, Wählby, Carolina, Siyuan, Wang, Yaniv, Ziv, and Strambio-De-Castillia, Caterina

Subjects
Quantitative Biology - Other Quantitative Biology
Abstract

Together with the molecular knowledge of genes and proteins, biological images promise to significantly enhance the scientific understanding of complex cellular systems and to advance predictive and personalized therapeutic products for human health. For this potential to be realized, quality-assured image data must be shared among labs at a global scale to be compared, pooled, and reanalyzed, thus unleashing untold potential beyond the original purpose for which the data was generated. There are two broad sets of requirements to enable image data sharing in the life sciences. One set of requirements is articulated in the companion White Paper entitled Enabling Global Image Data Sharing in the Life Sciences, which is published in parallel and addresses the need to build the cyberinfrastructure for sharing the digital array data. In this White Paper, we detail a broad set of requirements, which involves collecting, managing, presenting, and propagating contextual information essential to assess the quality, understand the content, interpret the scientific implications, and reuse image data in the context of the experimental details. We start by providing an overview of the main lessons learned to date through international community activities, which have recently made considerable progress toward generating community standard practices for imaging Quality Control (QC) and metadata. We then provide a clear set of recommendations for amplifying this work. The driving goal is to address remaining challenges and democratize access to everyday practices and tools for a spectrum of biomedical researchers, regardless of their expertise, access to resources, and geographical location., Comment: This manuscript is published with a closely related companion entitled, Enabling Global Image Data Sharing in the Life Sciences, which can be found at the following link, arXiv:2401.13023 [q-bio.OT]

Published
2024

3. Scaling of an antibody validation procedure enables quantification of antibody performance in major research applications.

Author

Ayoubi, Riham, Ryan, Joel, Biddle, Michael S, Alshafie, Walaa, Fotouhi, Maryam, Bolivar, Sara Gonzalez, Ruiz Moleon, Vera, Eckmann, Peter, Worrall, Donovan, McDowell, Ian, Southern, Kathleen, Reintsch, Wolfgang, Durcan, Thomas M, Brown, Claire, Bandrowski, Anita, Virk, Harvinder, Edwards, Aled M, McPherson, Peter, and Laflamme, Carl

Subjects
Biochemistry and Cell Biology, Biological Sciences, Biotechnology, Generic health relevance, Humans, Proteome, antibody characterization, antibody validation, biochemistry, cell biology, chemical biology, human, human proteome, open science, recombinant antibodies, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

Antibodies are critical reagents to detect and characterize proteins. It is commonly understood that many commercial antibodies do not recognize their intended targets, but information on the scope of the problem remains largely anecdotal, and as such, feasibility of the goal of at least one potent and specific antibody targeting each protein in a proteome cannot be assessed. Focusing on antibodies for human proteins, we have scaled a standardized characterization approach using parental and knockout cell lines (Laflamme et al., 2019) to assess the performance of 614 commercial antibodies for 65 neuroscience-related proteins. Side-by-side comparisons of all antibodies against each target, obtained from multiple commercial partners, have demonstrated that: (i) more than 50% of all antibodies failed in one or more applications, (ii) yet, ~50-75% of the protein set was covered by at least one high-performing antibody, depending on application, suggesting that coverage of human proteins by commercial antibodies is significant; and (iii) recombinant antibodies performed better than monoclonal or polyclonal antibodies. The hundreds of underperforming antibodies identified in this study were found to have been used in a large number of published articles, which should raise alarm. Encouragingly, more than half of the underperforming commercial antibodies were reassessed by the manufacturers, and many had alterations to their recommended usage or were removed from the market. This first study helps demonstrate the scale of the antibody specificity problem but also suggests an efficient strategy toward achieving coverage of the human proteome; mine the existing commercial antibody repertoire, and use the data to focus new renewable antibody generation efforts.

Published
2023

8. Influence of microbial community on nitrogen loss through denitrification in agriculture

Author

Moulton-Brown, Claire Elizabeth, Moir, James, Helgason, Thorunn, and Dytham, Calvin

Abstract

Global food demand is expected to rise by up to 62% by 2050, with an increasing population and finite land available for food production. Denitrification causes loss of fixed nitrogen from soil systems, thereby reducing crop productivity. Current nitrogen cycling models cannot fully explain the variation in nitrogen use efficiency at the field scale; this variation is thought to be associated with microbial community dynamics. The dynamics of denitrification and denitrifying communities are affected by the physicochemical properties of the soil, and therefore the land management practices which alter them. In this thesis, we look at the effects of land management history and innate environmental variation using a long-term factorial field trial, a working commercial farm, and laboratory-based experiments. By studying the denitrifier community composition, abundance and diversity in the context of environmental data, we were able to address the question of how specific land management practices and innate spatiotemporal variation affects the distribution of denitrifiers within arable soils. It was found that bacterial and denitrifier communities are largely unaffected by land management history, and cluster predominantly along environmental gradients. Additionally, there was a high degree of spatiotemporal variation in soil denitrifying communities, with implications for future sampling strategies as well as computer modelling. Finally, it was established that isolation of bacteria from the environment is a viable method for culturing non-model organisms that can be characterized and used to inform nitrogen-cycling models. In this combination of well-established agricultural field trial and working commercial farm, the major identifiable determinant of bacterial community dissimilarity was a blend of physicochemical factors. The importance of selection on bacterial communities, relative to ecological drift, may have consequences for attempts to understand and model nutrient availabilities in arable farming systems, and improve agricultural productivity to feed the growing global population.

Published
2022

9. Advances for Future Working Following an Online Dramatherapy Group for Adults with Intellectual Disabilities and Mental Ill Health during the COVID-19 Pandemic: A Service Evaluation for Cumbria, Northumberland Tyne and Wear NHS Foundation Trust

Author

Bourne, Jane, Brown, Claire, Corrigan, Debbie, Goldblatt, Phil, and Hackett, Simon

Abstract

Background: During the COVID-19 pandemic, social distancing measures were enforced and the national lockdown underlined our reliance on virtual means as a way to communicate. This new way of interacting highlighted that people with an intellectual disability were a large proportion of a digitally excluded population. Methods: A service evaluation, using a mixed method design in the form of four self-reported outcome measures and qualitative feedback. Findings: Clinical services need to continue when face to face sessions are not possible. Remote groups can be an alternative option not only when self-isolating due to pandemics but when living in remote locations, having physical health problems or excessive expenses and travel costs. Conclusions: Online dramatherapy groups can be a beneficial alternative when face to face groups are not possible or challenging to attend due to access difficulties. Online groups can offer opportunities to meet with peers, build relationships, improve confidence and learn new skills in technology.

Published
2022
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11. QUAREP-LiMi: A community-driven initiative to establish guidelines for quality assessment and reproducibility for instruments and images in light microscopy

Author

Nelson, Glyn, Boehm, Ulrike, Bagley, Steve, Bajcsy, Peter, Bischof, Johanna, Brown, Claire M, Dauphin, Aurelien, Dobbie, Ian M, Eriksson, John E, Faklaris, Orestis, Fernandez-Rodriguez, Julia, Ferrand, Alexia, Gelman, Laurent, Gheisari, Ali, Hartmann, Hella, Kukat, Christian, Laude, Alex, Mitkovski, Miso, Munck, Sebastian, North, Alison J, Rasse, Tobias M, Resch-Genger, Ute, Schuetz, Lucas C, Seitz, Arne, Strambio-De-Castillia, Caterina, Swedlow, Jason R, Alexopoulos, Ioannis, Aumayr, Karin, Avilov, Sergiy, Bakker, Gert-Jan, Bammann, Rodrigo R, Bassi, Andrea, Beckert, Hannes, Beer, Sebastian, Belyaev, Yury, Bierwagen, Jakob, Birngruber, Konstantin A, Bosch, Manel, Breitlow, Juergen, Cameron, Lisa A, Chalfoun, Joe, Chambers, James J, Chen, Chieh-Li, Conde-Sousa, Eduardo, Corbett, Alexander D, Cordelieres, Fabrice P, Del Nery, Elaine, Dietzel, Ralf, Eismann, Frank, Fazeli, Elnaz, Felscher, Andreas, Fried, Hans, Gaudreault, Nathalie, Goh, Wah Ing, Guilbert, Thomas, Hadleigh, Roland, Hemmerich, Peter, Holst, Gerhard A, Itano, Michelle S, Jaffe, Claudia B, Jambor, Helena K, Jarvis, Stuart C, Keppler, Antje, Kirchenbuechler, David, Kirchner, Marcel, Kobayashi, Norio, Krens, Gabriel, Kunis, Susanne, Lacoste, Judith, Marcello, Marco, Martins, Gabriel G, Metcalf, Daniel J, Mitchell, Claire A, Moore, Joshua, Mueller, Tobias, Nelson, Michael S, Ogg, Stephen, Onami, Shuichi, Palmer, Alexandra L, Paul-Gilloteaux, Perrine, Pimentel, Jaime A, Plantard, Laure, Podder, Santosh, Rexhepaj, Elton, Royon, Arnaud, Saari, Markku A, Schapman, Damien, Schoonderwoert, Vincent, Schroth-Diez, Britta, Schwartz, Stanley, Shaw, Michael, Spitaler, Martin, Stoeckl, Martin T, Sudar, Damir, Teillon, Jeremie, Terjung, Stefan, Thuenauer, Roland, Wilms, Christian D, Wright, Graham D, and Nitschke, Roland

Subjects
Quantitative Biology - Other Quantitative Biology, Physics - Instrumentation and Detectors
Abstract

In April 2020, the QUality Assessment and REProducibility for Instruments and Images in Light Microscopy (QUAREP-LiMi) initiative was formed. This initiative comprises imaging scientists from academia and industry who share a common interest in achieving a better understanding of the performance and limitations of microscopes and improved quality control (QC) in light microscopy. The ultimate goal of the QUAREP-LiMi initiative is to establish a set of common QC standards, guidelines, metadata models, and tools, including detailed protocols, with the ultimate aim of improving reproducible advances in scientific research. This White Paper 1) summarizes the major obstacles identified in the field that motivated the launch of the QUAREP-LiMi initiative; 2) identifies the urgent need to address these obstacles in a grassroots manner, through a community of stakeholders including, researchers, imaging scientists, bioimage analysts, bioimage informatics developers, corporate partners, funding agencies, standards organizations, scientific publishers, and observers of such; 3) outlines the current actions of the QUAREP-LiMi initiative, and 4) proposes future steps that can be taken to improve the dissemination and acceptance of the proposed guidelines to manage QC. To summarize, the principal goal of the QUAREP-LiMi initiative is to improve the overall quality and reproducibility of light microscope image data by introducing broadly accepted standard practices and accurately captured image data metrics., Comment: 17 pages, 3 figures, shortened abstract, Co-Lead Authors: Glyn Nelson and Ulrike Boehm, Corresponding author: Roland Nitschke

Published
2021
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13. A Global View of Standards for Open Image Data Formats and Repositories

Author

Swedlow, Jason R., Kankaanpää, Pasi, Sarkans, Ugis, Goscinski, Wojtek, Galloway, Graham, Sullivan, Ryan P., Brown, Claire M., Wood, Chris, Keppler, Antje, Loos, Ben, Zullino, Sara, Longo, Dario Livio, Aime, Silvio, and Onami, Shuichi

Subjects
Quantitative Biology - Other Quantitative Biology
Abstract

Biological and biomedical imaging datasets record the constitution, architecture and dynamics of living organisms across several orders of magnitude of space and time. Imaging technologies are now used throughout the life and biomedical sciences to achieve discovery and understanding of biological mechanisms in the basic sciences as well as assessment, diagnosis and therapeutic intervention in clinical trials and animal and human medicine. The universal application and use of imaging raises an important question and opportunity: what is the value and ultimate destination of biological and medical imaging data? In the last few years, several informatics and data science technologies have matured sufficiently so that routine publication of these datasets is now possible. Participants in Global BioImaging from 15 countries and all populated continents have agreed on the need for recommendations and guidelines for the establishment of image data repositories and the formats they use for delivering data to the global scientific community. This white paper presents a shared, global view of criteria for these common, globally applicable guidelines and provisional proposals for open tools and resources that are available now and can provide a foundation for future development.

Published
2020

14. EnGendering inclusive practice : exploring trans people's experiences of adoption and fostering in England and Wales

Author

Brown, Claire, Rogers, Michalea, and Sen, Robin

Abstract

This thesis presents the findings of a narrative inquiry exploring the lived experiences and perceptions that trans and non-binary people have in relation to adopting or fostering a child in England and Wales. Since the 1950s, adoption and fostering agencies have acted as 'gatekeepers', deciding who is deemed a suitable parent/carer and who is not. Adoption and fostering agencies have tended to espouse gender normative views in their practices. This amounts to covert discrimination as these practices disadvantage people who identify outside of normative frameworks of gender. This research addresses a gap in the research, bringing trans people's voices into fostering and adoption social work in England and Wales. The results of ten in-depth semi-structured interviews are examined. These include eight trans people who have adopted/fostered or who hope to adopt/foster and two social workers who have been involved in recruiting, assessing or supporting trans carers. Narratives of personal identity, family, fostering and adoption are explored within this thesis and analysed using a theoretical framework which includes cisgenderism, stigma and discourses of power to explicate the sociology of trans people's experiences. Cisgenderism was found to operate in different ways upon different experiences, hindering the life and family opportunities of trans and non-binary people. The negative effects of cisgenderism could be especially pronounced for those whose identities did not align with a binary designation of gender. Findings and conclusions are used to make recommendations for good practice in social work and to suggest future research directions.

Published
2021

16. Early Career Teacher Professional Development: Bridging Simulation Technology with Evidence-Based Behavior Management

Author

Shernoff, Elisa, Frazier, Stacy, Lisetti, Christine, Buche, Cedric, Lunn, Stephanie, Brown, Claire, Delmarre, Alban, Chou, Tommy, Gabbard, Joseph, and Morgan, Emily

Abstract

Early career teachers working in high poverty schools face of overwhelming challenges navigating disruptive behaviors with studies highlighting behavior problems as one of the strongest predictors of turnover (Ingersoll & Smith, 2003). Simulation-based technology leverages important pedagogical strengths (e.g., realistic training context, opportunities for practice and feedback, low-stakes training) that may confer advantage over traditional training for teachers in behavior management. This manuscript illustrates the development and refinement of Interactive Virtual Training for Teachers (IVT-T), a simulation-training model to help early career teachers hone their behavior management skills by interacting with virtual students in a 3D classroom. Advisory board members (N=5) with extensive experience in high poverty schools provided iterative feedback on the authenticity and realism of IVT-T students, classrooms, and vignettes. Advisory board members rated authenticity/realism of the students, classrooms, and vignettes favorably and ratings also increased over time as new prototypes were shared. In addition, prototypes introduced earlier underwent more revisions than prototypes introduced later suggesting advisory board feedback helped the computer science team improve upon their development approach. Open-ended feedback revealed important shortcomings and the need for further refinements to improve the training model. Implications for teacher educators and researchers involved in the development of instructional technologies are discussed. [This paper was published in "Journal of Technology and Teacher Education" v26 n2 p299-326 2018 (EJ1181030).]

Published
2018

17. A perspective on Microscopy Metadata: data provenance and quality control

Author

Huisman, Maximiliaan, Hammer, Mathias, Rigano, Alex, Boehm, Ulrike, Chambers, James J., Gaudreault, Nathalie, North, Alison J., Pimentel, Jaime A., Sudar, Damir, Bajcsy, Peter, Brown, Claire M., Corbett, Alexander D., Faklaris, Orestis, Lacoste, Judith, Laude, Alex, Nelson, Glyn, Nitschke, Roland, Grunwald, David, and Strambio-De-Castillia, Caterina

Subjects
Quantitative Biology - Quantitative Methods, Computer Science - Databases
Abstract

The application of microscopy in biomedical research has come a long way since Antonie van Leeuwenhoek discovered unicellular organisms. Countless innovations have positioned light microscopy as a cornerstone of modern biology and a method of choice for connecting omics datasets to their biological and clinical correlates. Still, regardless of how convincing published imaging data looks, it does not always convey meaningful information about the conditions in which it was acquired, processed, and analyzed. Adequate record-keeping, reporting, and quality control are therefore essential to ensure experimental rigor and data fidelity, allow experiments to be reproducibly repeated, and promote the proper evaluation, interpretation, comparison, and re-use. To this end, microscopy images should be accompanied by complete descriptions detailing experimental procedures, biological samples, microscope hardware specifications, image acquisition parameters, and image analysis procedures, as well as metrics accounting for instrument performance and calibration. However, universal, community-accepted Microscopy Metadata standards and reporting specifications that would result in Findable Accessible Interoperable and Reproducible (FAIR) microscopy data have not yet been established. To understand this shortcoming and to propose a way forward, here we provide an overview of the nature of microscopy metadata and its importance for fostering data quality, reproducibility, scientific rigor, and sharing value in light microscopy. The proposal for tiered Microscopy Metadata Specifications that extend the OME Data Model put forth by the 4D Nucleome Initiative and by Bioimaging North America [1-3] as well as a suite of three complementary and interoperable tools are being developed to facilitate the process of image data documentation and are presented in related manuscripts [4-6].

Published
2019

23. Efficacy, safety, and immunogenicity of a booster regimen of Ad26.COV2.S vaccine against COVID-19 (ENSEMBLE2): results of a randomised, double-blind, placebo-controlled, phase 3 trial

Author

Garibaldi, Brian T., Albertson, Timothy E., Sandrock, Christian, Lee, Janet S., Looney, Mark R., Tapson, Victor F., Wiysonge, Charles Shey, Velarde, Luis Humberto Anaya, Backenroth, Daniel, Bhushanan, Jisha, Brandenburg, Börries, Cárdenas, Vicky, Chen, Bohang, Chen, Fei, Chetty, Polan, Chu, Pei-Ling, Cooper, Kimberly, Custers, Jerome, Delanghe, Hilde, Duca, Anna, Henrick, Tracy, Juraszek, Jarek, Nalpas, Catherine, Peeters, Monika, Pinheiro, Jose, Roels, Sanne, Ryser, Martin F., Salas, Jose, Santoro Matias, Samantha, Scheys, Ilse, Shetty, Pallavi, Shukarev, Georgi, Stoddard, Jeffrey, Talloen, Willem, Tran, NamPhuong, Vaissiere, Nathalie, van Son-Palmen, Elisabeth, Xu, Jiajun, Goecker, Erin A., Greninger, Alexander L., Jerome, Keith R., Roychoudhury, Pavitra, Takuva, Simbarashe G., Accini Mendoza, Jose Luis, Achtyes, Eric, Ahsan, Habibul, Alhatemi, Azhar, Allen, Nancy, Arribas, Jose R., Bahrami, Ghazaleh, Bailon, Lucia, Bajwa, Ali, Baker, Jonathan, Baron, Mira, Benet, Susana, Berdaï, Driss, Berger, Patrick, Bertoch, Todd, Bethune, Claire, Bevilacqua, Sybille, Biagioni Santos, Maria Silvia, Binnian, Ian, Bisnauthsing, Karen, Boivin, Jean-Marc, Bollen, Hilde, Bonnet, Sandrine, Borobia, Alberto M., Botelho-Nevers, Elisabeth, Bright, Phil, Britten, Vianne, Brown, Claire, Buadi, Amanda, Buntinx, Erik, Burgess, Lesley, Bush, Larry, Capeding, Maria Rosario, Carr, Quito Osuna, Carrasco Mas, Amparo, Catala, Hélène, Cathie, Katrina, Caudill, T. Shawn, Cereto Castro, Fernando, Chau, Kénora, Chavoustie, Steven, Chowdhury, Marie, Chronos, Nicolas, Cicconi, Paola, Cifuentes, Liliana, Cobo, Sara Maria, Collins, Helen, Colton, Hayley, Cuaño, Carlos Rolando G., D'Onofrio, Valentino, Dargan, Paul, Darton, Thomas, Deane, Peter, Del Pozo, Jose Luis, Derdelinckx, Inge, Desai, Amisha, Dever, Michael, Díaz-Pollán, Beatriz, DiBuono, Mark, Doust, Matthew, Duncan, Christopher, Echave-Sustaeta, Jose Maria, Eder, Frank, Ellis, Kimberly, Elzi, Stanton, Emmett, Stevan, Engelbrecht, Johannes, Evans, Mim, Farah, Theo, Felton, Timothy, Ferreira, João Pedro, Floutier, Catherine, Flume, Patrick, Ford, Stacy, Fragoso, Veronica, Freedman, Andrew, Frentiu, Emilia, Galloway, Christopher, Galtier, Florence, Garcia Diaz, Julia, García García, Irene, Garcia, Alcaide, Gardener, Zoe, Gauteul, Pascale, Geller, Steven, Gibson, Andrew, Gillet, Claudia, Girerd, Nicolas, Girodet, Pierre-Olivier, Gler, Maria Tarcela, Glover, Richard, Go, Herschel Don D., Gokani, Karishma, Gonthier, Damien, Green, Christopher, Greenberg, Richard, Griffin, Carl, Grobbelaar, Coert, Guancia, Adonis, Hakkarainen, Gloria, Harris, James, Hassman, Michael, Heimer, Deirdre, Hellstrom-Louw, Elizabeth, Herades, Yoan, Holroyd, Christopher, Hussen, Nazreen, Isidro, Marie Grace Dawn, Jackson, Yvonne, Jain, Manish, João Filho, Esaú Custódio, Johnson, Daniel, Jones, Ben, Joseph, Natasha, Jumeras, Analyn, Junquera, Patricia, Kellett-Wright, Johanna, Kennedy, Patrick, Kilgore, Paul E., Kim, Kenneth, Kimmel, Murray, Konis, George, Kutner, Mark, Lacombe, Karine, Launay, Odile, Lazarus, Rajeka, Lederman, Samuel, Lefebvre, Gigi, Lennon Collins, Katrina, Leroux-Roels, Isabel, Lim, Kenneth Wilson O., Lins, Muriel, Liu, Edward, Llewelyn, Martin, Mahomed, Akbar, Maia, Bernardo Porto, Marín-Candon, Alícia, Martínez-Gómez, Xavier, Martinot, Jean Benoit, Mazzella, Andrea, McCaughan, Frank, McCormack, Louise, McGettigan, John, Mehra, Purvi, Mejeur, Rhonda, Miller, Vicki, Mills, Anthony, Molto Marhuenda, Jose, Moodley, Prebashan, Mora-Rillo, Marta, Mothe, Beatriz, Mullan, Daniel, Munro, Alasdair, Myers, Paul, Nell, Jeremy, Newman Lobato Souza, Tamara, O'Halloran, Jane A., Ochoa Mazarro, Maria Dolores, Oliver, Abigail, Onate Gutierrez, Jose Millan, Ortega, Jessica, Oshita, Masaru, Otero Romero, Susana, Overcash, Jeffrey Scott, Owens, Daniel, Packham, Alice, Pacurar, Mihaela, Paiva de Sousa, Leonardo, Palfreeman, Adrian, Pallares, Christian José, Patel, Rahul, Patel, Suchet, Pelkey, Leslie, Peluso, Denise, Penciu, Florentina, Pinto, S. Jerry, Pounds, Kevin, Pouzar, Joe, Pragalos, Antoinette, Presti, Rachel, Price, David, Qureshi, Ehsaan, Ramalho Madruga, José Valdez, Ramesh, Mayur, Rankin, Bruce, Razat, Béatrice, Riegel Santos, Breno, Riesenberg, Robert, Riffer, Ernie, Roche, Siobhan, Rose, Katie, Rosellini, Pietro, Rossignol, Patrick, Safirstein, Beth, Salazar, Hernan, Sanchez Vallejo, Gregorio, Santhosh, Smrithi, Seco-Meseguer, Enrique, Seep, Michael, Sherry, Emma, Short, Philip, Soentjens, Patrick, Solis, Joel, Soriano Viladomiu, Alejandro, Sorli, Caroline, Spangenthal, Selwyn, Spence, Niamh, Stephenson, Elaine, Strout, Cynthia, Surowitz, Ronald, Taladua, Kristy Michelle, Tellalian, David, Thalamas, Claire, Thiriphoo, Nang, Thomas, Judith, Thomas, Nicholas, Trout, Guillermo, Urroz, Mikel, Veekmans, Bernard, Veekmans, Laurent, Villalobos, Ralph Elvi M., Warren, Sarah, Webster, Brian, White, Alexander, Williams, Gail, Williams, Hayes, Wilson, Barbara, Winston, Alan, Wiselka, Martin, Zervos, Marcus, Hardt, Karin, Vandebosch, An, Sadoff, Jerald, Le Gars, Mathieu, Truyers, Carla, Lowson, David, Van Dromme, Ilse, Vingerhoets, Johan, Kamphuis, Tobias, Scheper, Gert, Ruiz-Guiñazú, Javier, Faust, Saul N, Spinner, Christoph D, Schuitemaker, Hanneke, Van Hoof, Johan, Douoguih, Macaya, and Struyf, Frank

Published
2022
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24. Effect of priming interval on reactogenicity, peak immunological response, and waning after homologous and heterologous COVID-19 vaccine schedules: exploratory analyses of Com-COV, a randomised control trial

Author

Munro, Alasdair P.S., Bartholomew, Jazz, Presland, Laura, Horswill, Sarah, Warren, Sarah, Varkonyi-Clifford, Sophie, Saich, Stephen, Adams, Kirsty, Ricamara, Marivic, Turner, Nicola, Yee Ting, Nicole Y., Whittley, Sarah, Rampling, Tommy, Desai, Amisha, Brown, Claire H., Qureshi, Ehsaan, Gokani, Karishma, Naker, Kush, Kellett Wright, Johanna K., Williams, Rachel L., Riaz, Tawassal, Penciu, Florentina D., Carson, Amy, Di Maso, Claudio, Mead, Gracie, Howe, Elizabeth G., Vichos, Iason, Ghulam Farooq, Mujtaba, Noristani, Rabiullah, Yao, Xin L., Oldfield, Neil J., Hammersley, Daniel, Belton, Sue, Royal, Simon, San Francisco Ramos, Alberto, Hultin, Cecilia, Galiza, Eva P., Crook, Rebecca, Bula, Marcin, Fyles, Fred, Burhan, Hassan, Maelin, Flora, Hughes, Elen, Okenyi, Emmanuel, Shaw, Robert H, Liu, Xinxue, Stuart, Arabella S V, Greenland, Melanie, Aley, Parvinder K, Andrews, Nick J, Cameron, J Claire, Charlton, Sue, Clutterbuck, Elizabeth A, Collins, Andrea M, Dejnirattisai, Wanwisa, Dinesh, Tanya, Faust, Saul N, Ferreira, Daniela M, Finn, Adam, Green, Christopher A, Hallis, Bassam, Heath, Paul T, Hill, Helen, Lambe, Teresa, Lazarus, Rajeka, Libri, Vincenzo, Long, Fei, Mujadidi, Yama F, Plested, Emma L, Morey, Ella R, Provstgaard-Morys, Samuel, Ramasamy, Maheshi N, Ramsay, Mary, Read, Robert C, Robinson, Hannah, Screaton, Gavin R, Singh, Nisha, Turner, David P J, Turner, Paul J, Walker, Laura L, White, Rachel, Nguyen-Van-Tam, Jonathan S, and Snape, Matthew D

Published
2022
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26. Safety, immunogenicity, and reactogenicity of BNT162b2 and mRNA-1273 COVID-19 vaccines given as fourth-dose boosters following two doses of ChAdOx1 nCoV-19 or BNT162b2 and a third dose of BNT162b2 (COV-BOOST): a multicentre, blinded, phase 2, randomised trial

Author

Munro, Alasdair P S, Feng, Shuo, Janani, Leila, Cornelius, Victoria, Aley, Parvinder K, Babbage, Gavin, Baxter, David, Bula, Marcin, Cathie, Katrina, Chatterjee, Krishna, Dodd, Kate, Enever, Yvanne, Qureshi, Ehsaan, Goodman, Anna L, Green, Christopher A, Harndahl, Linda, Haughney, John, Hicks, Alexander, van der Klaauw, Agatha A, Kanji, Nasir, Libri, Vincenzo, Llewelyn, Martin J, McGregor, Alastair C, Minassian, Angela M, Moore, Patrick, Mughal, Mehmood, Mujadidi, Yama F, Holliday, Kyra, Osanlou, Orod, Osanlou, Rostam, Owens, Daniel R, Pacurar, Mihaela, Palfreeman, Adrian, Pan, Daniel, Rampling, Tommy, Regan, Karen, Saich, Stephen, Bawa, Tanveer, Saralaya, Dinesh, Sharma, Sunil, Sheridan, Ray, Maallah, Mina, Thomson, Emma C, Todd, Shirley, Twelves, Chris, Read, Robert C, Charlton, Sue, Hallis, Bassam, Ramsay, Mary, Andrews, Nick, Lambe, Teresa, Nguyen-Van-Tam, Jonathan S, Snape, Matthew D, Liu, Xinxue, Faust, Saul N, Riordan, Andrew, Ustianowski, Andrew, Rogers, Chris, Katechia, Kashyap, Cooper, Alison, Freedman, Andrew, Hughes, Rachel, Grundy, Lynne, Tudor Jones, Lona, Harrison, Elizabeth, Snashall, Emma, Mallon, Lewis, Burton, Katharine, Storton, Kim, Munusamy, Malathi, Tandy, Bridget, Egbo, Akamino, Cox, Stephen, Ahmed, Nabeela Nazir, Shenoy, Anil, Bousfield, Rachel, Wixted, Donna, Gutteridge, Helen, Mansfield, Becky, Herbert, Christopher, Murira, Jennifer, Calderwood, James, Barker, Dominique, Brandon, Jacqueline, Tulloch, Hayley, Colquhoun, Suzie, Thorp, Helen, Radford, Helen, Evans, Julie, Baker, Helena, Thorpe, Jeanette, Batham, Sally, Hailstone, Jessica, Phillips, Rachael, Kumar, Dileep, Westwell, Fran, Sturdy, Ann, Barcella, Lara, Soussi, Najwa, Mpelembue, Mushiya, Raj, Sreena, Sharma, Rajni, Corrah, Tumena, John, Laurence, Whittington, Ashley, Roche, Siobhan, Wagstaff, Lynda, Farrier, Adam, Bisnauthsing, Karen, Abeywickrama, Movin, Spence, Niamh, Packham, Alice, Serafimova, Teona, Aslam, Suahil, McGreevy, Caitlin, Borca, Alessandro, DeLosSantosDominguez, Pamela, Palmer, Emily, Broadhead, Samantha, Farooqi, Sadaf, Piper, Jo, Weighell, Rowena, Pickup, Lorinda, Shamtally, Djamila, Domingo, Jason, Kourampa, Evgenia, Hale, Colin, Gibney, Jennifer, Stackpoole, Michael, Rashid-Gardner, Zalina, Lyon, Rebecca, McDonnell, Chloe, Cole, Christine, Stewart, Anna, McMillan, Gillian, Savage, Mary, Beckett, Helen, Moorbey, Chantelle, Desai, Amisha, Brown, Claire, Naker, Kush, Gokani, Karishma, Trinham, Charlotte, Sabine, Charlette, Moore, Sophie, Hurdover, Steve, Justice, Edwin, Stone, Megan, Plested, Emma, Ferreira Da Silva, Carla, White, Rachel, Robinson, Hannah, Turnbull, Iain, Morshead, Gertraud, Drake-Brockman, Rachael, Smith, Catherine, Li, Grace, Kasanyinga, Mwila, Clutterbuck, Elizabeth A, Bibi, Sagida, Singh, Michael, Champaneri, Trishna, Irwin, Margaret, Khan, Mohammed, Kownacka, Alicia, Nabunjo, Martha, Osuji, Carol, Hladkiwskyj, John, Galvin, Dominic, Patel, Gita, Grierson, Jacques, Males, Samantha, Askoolam, Krishna, Barry, Joshua, Mouland, Johanna, Longhurst, Beverley, Moon, Maria, Giddins, Beth, Pereira Dias Alves, Carlota, Richmond, Leah, Minnis, Christine, Baryschpolec, Sonia, Elliott, Scott, Fox, Lauren, Graham, Victoria, Baker, Natalie, Godwin, Kerry, Buttigieg, Karen, Knight, Chanice, Brown, Phillip, Lall, Paminder, Shaik, Imam, Chiplin, Emily, Brunt, Emily, Leung, Stephanie, Allen, Lauren, Thomas, Steve, Fraser, Sara, Choi, Bea, Gouriet, Jade, Perkins, Jonathan, Gowland, Andrew, Macdonald, Jonathan, Seenan, John Paul, Starinskij, Igor, Seaton, Andrew, Peters, Erica, Singh, Stephen, Gardside, Ben, Bonnaud, Avril, Davies, Ceri, Gordon, Elizabeth, Keenan, Samantha, Hall, Jane, Wilkins, Suzanne, Tasker, Suzanne, James, Rob, Seath, Ingrid, Littlewood, Kelly, Newman, Joseph, Boubriak, Iryna, Suggitt, Debbie, Haydock, Helen, Bennett, Sara, Woodyatt, Wiesia, Hughes, Kerry, Bell, Judith, Coughlan, Tricia, van Welsenes, Donald, Kamal, Mohammed, Cooper, Chris, Tunstall, Simon, Ronan, Nicholas, Cutts, Rebecca, Dare, Tracey, Yim, Yee Ting Nicole, Whittley, Sarah, Hamal, Shama, Ricamara, Marivic, Adams, Kirsty, Baker, Holly, Driver, Kimberley, Turner, Nicola, Rawlins, Todd, Roy, Subarna, Merida-Morillas, Marta, Sakagami, Yukari, Andrews, Antonette, Goncalvescordeiro, Lillian, Stokes, Matthew, Ambihapathy, Wythehi, Spencer, Joanne, Parungao, Nina, Berry, Lisa, Cullinane, James, Presland, Laura, Ross Russell, Amy, Warren, Sarah, Baker, Jonathan, Oliver, Abigail, Buadi, Amanda, Lee, Kim, Haskell, Louise, Romani, Rossana, Bentley, Ian, Whitbred, Tim, Fowler, Simon, Gavin, John, Magee, Alan, Watson, Tara, Nightingale, Kari, Marius, Phedra, Summerton, Eloise, Locke, Emily, Honey, Thomas, Lingwood, Aidan, de la Haye, Anastasia, Elliott, Ryan Stephen, Underwood, Karen, King, Mikayala, Davies-Dear, Sharon, Horsfall, Emily, Chalwin, Olivia, Burton, Holly, Edwards, Christopher J, Welham, Benjamin, Appleby, Kim, Dineen, Emily, Garrahy, Sarah, Hall, Fran, Ladikou, Eleni, Mullan, Dee, Hansen, Daniel, Campbell, Marion, Dos Santos, Filipa, Lakeman, Nicki, Branney, Debbie, Vamplew, Luke, Hogan, Alison, Frankham, Jorden, Wiselka, Martin, Vail, Denny, Wenn, Victoria, Renals, Valerie, Ellis, Kate, Lewis-Taylor, Jessica, Habash-Bailey, Haniah, Magan, Javier, and Hardy, Anna

Published
2022
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27. Between a rock and a hard place : an insight into the psychological therapist's experience of having safeguarding concerns for their clients' children

Author

Brown, Claire

Subjects
150
Abstract

This study explores the therapists' experience when managing safeguarding concerns about their clients' children, with the aim of raising awareness and bringing the child into the therapists' mind. A review of the literature indicated that this is an undeveloped area, with existing research lacking attention to the impact of the therapeutic relationship on this ethical dilemma. IPA (interpretative phenomenological analysis) was used to analyse the findings from six semistructured interviews with a mix of psychological therapists who had experienced concerns for their clients' children while working in non-NHS settings. This approach allows for an in-depth exploration into the subjective experience of the participant, while also recognising the reflective role of the researcher. The findings indicate that therapists are struggling with a lack of confidence and experience in managing their child protection concerns, with an indication of a training need. This lack of confidence, combined with a range of complex emotions evoked in such work, increased the participants' need for support and supervision. Participants felt the need to alter their therapeutic practice and become more directive in order to ascertain clearer details about their concerns. The findings have implications for the training and continued professional development requirements for psychological therapists. There is an indication for training focused on managing concerns in the context of the therapeutic relationship, more training around assessing the level of risk and the development of a prompt sheet with reflective questions to aid therapists in their thinking. An identified limitation of this study is the range of participants in terms of gender and ethnicity; further research could explore more thoroughly whether these factors influence how concerns are managed. There is also scope to explore more specifically the impact of the therapeutic placement, to identify whether those working within large organisations, such as the NHS, feel more supported and contained in this type of work than those working more independently.

Published
2018

28. 'It wasn't adults and young people [...] we're all in it together': co-designing a post-secondary transition program through youth participatory action research.

Author

Luguetti, Carla, Ryan, Juliana, Eckersley, Bill, Howard, Amy, Buck, Sarah, Osman, Aisha, Hansen, Chloe, Galati, Patrick, Cahill, Robinson Jack, Craig, Sarah, and Brown, Claire

Subjects
SECONDARY schools, CRITICAL consciousness, COLLABORATIONISTS (Traitors), EMOTIONS, CLINICAL trials
Abstract

This paper aims to contribute fresh insights into youth participatory action research (YPAR) by using bell hooks' engaged pedagogy to illuminate the process of co-designing a program for transition beyond secondary school. Engaged pedagogy is a critical pedagogy that combines critical consciousness and radical wholeness and seeks to foster a learning community. The 10-week YPAR included six staff collaborators (SCs) and five youth collaborators (YCs). Data comprised recordings of weekly collaborative group meetings; group interviews with SCs and YCs; and reflections and artefacts such as planning documents, graphic organisers and photographs. Informed by engaged pedagogy, findings are represented in two themes. First, YCs and SCs raised critical consciousness by collectively unpacking and critiquing the concept of transition. Critical consciousness allowed YCs to share their lived experiences and critique the dominant deficit discourse that represents transition as a linear process that needs to be smoothed by expert adults. Second, YCs and SCs demonstrated what hooks describes as radical wholeness, by bringing their whole selves to the YPAR. While some SCs and YCs struggled with the messiness of co-design as they negotiated expectations and roles, they learned to be honest and share their emotions, becoming what hooks describes as a learning community. Using an engaged pedagogy lens, we conclude by advocating for a holistic approach for YPAR in which educators take the risk of being vulnerable, sharing uncertainty and discomfort while encouraging youth to also take risks by bringing their whole selves to the process. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Together we grow: Evaluation of a design thinking professional development workshop for outdoor educators indicates improvements in growth mindset.

Author

Dadswell, Kara, Sambol, Stjepan, Yager, Zali, Van Dyke, Nina, Pascoe, Michaela, Dallat, Clare, Brown, Claire, and Parker, Alexandra G.

Subjects
DESIGN thinking, OUTDOOR education, PROBLEM solving, EXPERIENTIAL learning, COGNITIVE flexibility
Abstract

Design thinking is often proposed as an educative strategy to enhance growth mindset, problem solving, and creativity, but there are very few evaluations of the impact of experiential design thinking programs. The primary aim of this study was to investigate whether an online design-thinking workshop provided to outdoor education staff could improve their design-thinking traits. The pilot program was delivered over a 6-week period and comprised four, 2-hour sessions, in which teams worked together to actively engage in the steps of the design thinking process. Significant improvements were observed in participants' growth mindset and design thinking process—specifically, feedback seeking. Furthermore, design thinking was strongly correlated with growth mindset and cognitive flexibility; two constructs previously theorised to be associated with design thinking. This study provides a framework for constructing online design thinking workshops and how to effectively evaluate participant outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Micro-Meta App: an interactive tool for collecting microscopy metadata based on community specifications

Author

Rigano, Alessandro, Ehmsen, Shannon, Öztürk, Serkan Utku, Ryan, Joel, Balashov, Alexander, Hammer, Mathias, Kirli, Koray, Boehm, Ulrike, Brown, Claire M., Bellve, Karl, Chambers, James J., Cosolo, Andrea, Coleman, Robert A., Faklaris, Orestis, Fogarty, Kevin E., Guilbert, Thomas, Hamacher, Anna B., Itano, Michelle S., Keeley, Daniel P., Kunis, Susanne, Lacoste, Judith, Laude, Alex, Ma, Willa Y., Marcello, Marco, Montero-Llopis, Paula, Nelson, Glyn, Nitschke, Roland, Pimentel, Jaime A., Weidtkamp-Peters, Stefanie, Park, Peter J., Alver, Burak H., Grunwald, David, and Strambio-De-Castillia, Caterina

Published
2021
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33. Towards community-driven metadata standards for light microscopy: tiered specifications extending the OME model

Author

Hammer, Mathias, Huisman, Maximiliaan, Rigano, Alessandro, Boehm, Ulrike, Chambers, James J., Gaudreault, Nathalie, North, Alison J., Pimentel, Jaime A., Sudar, Damir, Bajcsy, Peter, Brown, Claire M., Corbett, Alexander D., Faklaris, Orestis, Lacoste, Judith, Laude, Alex, Nelson, Glyn, Nitschke, Roland, Farzam, Farzin, Smith, Carlas S., Grunwald, David, and Strambio-De-Castillia, Caterina

Published
2021
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34. QUAREP-LiMi: a community endeavor to advance quality assessment and reproducibility in light microscopy

Author

Boehm, Ulrike, Nelson, Glyn, Brown, Claire M., Bagley, Steve, Bajcsy, Peter, Bischof, Johanna, Dauphin, Aurelien, Dobbie, Ian M., Eriksson, John E., Faklaris, Orestis, Fernandez-Rodriguez, Julia, Ferrand, Alexia, Gelman, Laurent, Gheisari, Ali, Hartmann, Hella, Kukat, Christian, Laude, Alex, Mitkovski, Miso, Munck, Sebastian, North, Alison J., Rasse, Tobias M., Resch-Genger, Ute, Schuetz, Lucas C., Seitz, Arne, Strambio-De-Castillia, Caterina, Swedlow, Jason R., and Nitschke, Roland

Published
2021
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35. Safety and immunogenicity of seven COVID-19 vaccines as a third dose (booster) following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK (COV-BOOST): a blinded, multicentre, randomised, controlled, phase 2 trial

Author

Riordan, Andrew, Ustianowski, Andrew, Rogers, Chris A, Hughes, Stephen, Longshaw, Laura, Stockport, Jane, Hughes, Rachel, Grundy, Lynne, Tudor Jones, Lona, Guha, Arpan, Snashall, Emma, Eadsforth, Tom, Reeder, Sally, Storton, Kim, Munusamy, Malathi, Tandy, Bridget, Egbo, Akamino, Cox, Stephen, Ahmed, Nabeela Nazir, Shenoy, Anil, Bousfield, Rachel, Wixted, Donna, Gutteridge, Helen, Mansfield, Becky, Herbert, Christopher, Holliday, Kyra, Calderwood, James, Barker, Dominique, Brandon, Jacqueline, Tulloch, Hayley, Colquhoun, Suzie, Thorp, Helen, Radford, Helen, Evans, Julie, Baker, Helena, Thorpe, Jeanette, Batham, Sally, Hailstone, Jessica, Phillips, Rachael, Kumar, Dileep, Westwell, Fran, Makia, Fiona, Hopkins, NinaSimone, Barcella, Lara, Mpelembue, Mushiya, dabagh, Maja, lang, Matilda, khan, Farida, Adebambo, Olumide, Chita, Sunder, Corrah, Tumena, Whittington, Ashley, John, Laurence, Roche, Siobhan, Wagstaff, Lynda, Farrier, Adam, Bisnauthsing, Karen, Serafimova, Teona, Nanino, Elisa, Cooney, Enya, Wilson-Goldsmith, Jaimie, Nguyen, Hanna, Mazzella, Andrea, Jackson, Beth, Aslam, Suahil, Bawa, Tanveer, Broadhead, Samantha, Farooqi, Sadaf, Piper, Jo, Weighell, Rowena, Pickup, Lorinda, Shamtally, Djamila, Domingo, Jason, Kourampa, Evgenia, Hale, Colin, Gibney, Jennifer, Stackpoole, Michael, Rashid-Gardner, Zalina, Lyon, Rebecca, McDonnell, Chloe, Cole, Christine, Stewart, Anna, McMillan, Gillian, Savage, Mary, Beckett, Helen, Moorbey, Chantelle, Desai, Amisha, Brown, Claire, Naker, Kush, Qureshi, Ehsaan, Trinham, Charlotte, Sabine, Charlotte, Moore, Sophie, Hurdover, Steve, Justice, Edwin, Smith, David, Plested, Emma, Ferreira Da Silva, Carla, White, Rachel, Robinson, Hannah, Cifuentes, Liliana, Morshead, Gertraud, Drake-Brockman, Rachael, Kinch, Patrick, Kasanyinga, Mwila, Clutterbuck, Elizabeth A., Bibi, Sagida, Stuart, Arabella SV, Shaw, Robert H, Singh, Michael, Champaneri, Trishna, Irwin, Margaret, Khan, Mohammed, Kownacka, Alicja, Nabunjo, Martha, Osuji, Carool, Hladkiwskyj, John, Galvin, Dominic, Patel, Gita, Mouland, Johanna, Longhurst, Beverley, Moon, Maria, Giddins, Beth, Pereira Dias Alves, Carlota, Richmond, Leah, Minnis, Christine, Baryschpolec, Sonia, Elliott, Scott, Fox, Lauren, Graham, Victoria, Baker, Natalie, Godwin, Kerry, Buttigieg, Karren, Knight, Chanice, Brown, Phillip, Lall, Paminder, Shaik, Imam, Chiplin, Emily, Brunt, Emily, Leung, Stephanie, Allen, Lauren, Thomas, Steve, Fraser, Sara, Choi, Bea, Gouriet, Jade, Freedman, Andrew, Perkins, Jonathan, Gowland, Andrew, Macdonald, Jonathan, Seenan, John Paul, Starinskij, Igor, Seaton, Andrew, Peters, Erica, Singh, Stephen, Gardside, Ben, Bonnaud, Avril, Davies, Ceri, Gordon, Elizabeth, Keenan, Samantha, Hall, Jane, Wilkins, Suzanne, Tasker, Suzanne, James, Rob, Seath, Ingrid, Littlewood, Kelly, Newman, Joseph, Boubriak, Iryna, Suggitt, Debbie, Haydock, Helen, Bennett, Sara, Woodyatt, Wiesia, Hughes, Kerry, Bell, Judith, Coughlan, Tricia, van Welsenes, Donald, Kamal, Mohammed, Cooper, Chris, Tunstall, Simon, Ronan, Nicholas, Cutts, Rebecca, Dare, Tracey, Yim, Yee Ting Nicole, Whittley, Sarah, Ricamara, Marivic, Hamal, Shama, Adams, Kirsty, Baker, Holly, Driver, Kimberley, Turner, Nicola, Rawlins, Todd, Roy, Subarna, Merida-Morillas, Marta, Sakagami, Yukari, Andrews, Antonette, Goncalves cordeiro, Lillian, Stokes, Matthew, Ambihapathy, Wythehi, Spencer, Joanne, Parungao, Nina, Berry, Lisa, Cullinane, James, Presland, Laura, Ross-Russell, Amy, Warren, Sarah, Baker, Jonathan, Oliver, Abigail, Buadi, Amanda, Lee, Kim, Haskell, Louise, Romani, Rossana, Bentley, Ian, Whitbred, Tim, Fowler, Simon, Gavin, John, Magee, Alan, Watson, Tara, Nightingale, Kari, Marius, Phedra, Summerton, Eloise, Locke, Emily, Honey, Thomas, Lingwood, Aidan, de la Haye, Anastasia, Elliott, Ryan Stephen, Underwood, Karen, King, Mikayala, Davies-Dear, Sharon, Horsfall, Emily, Chalwin, Olivia, Burton, Holly, Edwards, Christopher J, Welham, Benjamin, Garrahy, Sarah, Hall, Fran, Ladikou, Eleni, Mullan, Dee, Hansen, Daniel, Campbell, Marion, Dos Santos, Filipa, Habash-Bailey, Haniah, Lakeman, Nicki, Branney, Debbie, Vamplew, Luke, Hogan, Alison, Frankham, Jorden, Wiselka, Martin, Vail, Dennyl, Wenn, Victoria, Renals, Valerie, Ellis, Kate, Lewis-Taylor, Jessica, Magan, Javier, Hardy, Anna, Appleby, Kim, Munro, Alasdair P S, Janani, Leila, Cornelius, Victoria, Aley, Parvinder K, Babbage, Gavin, Baxter, David, Bula, Marcin, Cathie, Katrina, Chatterjee, Krishna, Dodd, Kate, Enever, Yvanne, Gokani, Karishma, Goodman, Anna L, Green, Christopher A, Harndahl, Linda, Haughney, John, Hicks, Alexander, van der Klaauw, Agatha A, Kwok, Jonathan, Lambe, Teresa, Libri, Vincenzo, Llewelyn, Martin J, McGregor, Alastair C, Minassian, Angela M, Moore, Patrick, Mughal, Mehmood, Mujadidi, Yama F, Murira, Jennifer, Osanlou, Orod, Osanlou, Rostam, Owens, Daniel R, Pacurar, Mihaela, Palfreeman, Adrian, Pan, Daniel, Rampling, Tommy, Regan, Karen, Saich, Stephen, Salkeld, Jo, Saralaya, Dinesh, Sharma, Sunil, Sheridan, Ray, Sturdy, Ann, Thomson, Emma C, Todd, Shirley, Twelves, Chris, Read, Robert C, Charlton, Sue, Hallis, Bassam, Ramsay, Mary, Andrews, Nick, Nguyen-Van-Tam, Jonathan S, Snape, Matthew D, Liu, Xinxue, and Faust, Saul N

Published
2021
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36. Building momentum through networks: Bioimaging across the Americas

Author

De Niz, Mariana, primary, Escobedo García, Rodrigo, additional, Terán Ramirez, Celina, additional, Pakowski, Ysa, additional, Abonza, Yuriney, additional, Bialy, Nikki, additional, Orr, Vanessa L., additional, Olivera, Andres, additional, Abonza, Victor, additional, Alleva, Karina, additional, Allodi, Silvana, additional, Almeida, Michael F., additional, Becerril Cuevas, Alexis Ricardo, additional, Bonnet, Frederic, additional, Burgos Solorio, Armando, additional, Chew, Teng‐Leong, additional, Chiabrando, Gustavo, additional, Cimini, Beth, additional, Cleret‐Buhot, Aurélie, additional, Contreras Jiménez, Gastón, additional, Daza, Laura, additional, De Sá, Vanessa, additional, De Val, Natalia, additional, Delgado‐Álvarez, Diego L., additional, Eliceiri, Kevin, additional, Fiolka, Reto, additional, Grecco, Hernan, additional, Hanein, Dorit, additional, Hernández Herrera, Paúl, additional, Hockberger, Phil, additional, Hernandez, Haydee O., additional, Hernandez Guadarrama, Yael, additional, Itano, Michelle, additional, Jacobs, Caron A., additional, Jiménez‐García, Luis F., additional, Jiménez Sabinina, Vilma, additional, Kamaid, Andres, additional, Keppler, Antje, additional, Kumar, Abhishek, additional, Lacoste, Judith, additional, Lovy, Alenka, additional, Luby‐Phelps, Kate, additional, Mahadevan‐Jansen, Anita, additional, Malacrida, Leonel, additional, Mehta, Shalin B., additional, Miller, Caroline, additional, Miranda, Kildare, additional, Moore, Joshua A., additional, North, Alison, additional, O'Toole, Peter, additional, Olivares Urbano, Mariana, additional, Pietrasanta, Lía I., additional, Portugal, Rodrigo V., additional, Rossi, Andrés H., additional, Sanchez Contreras, Jonathan, additional, Strambio‐De‐Castilla, Caterina, additional, Soldevila, Gloria, additional, Vale, Bruno, additional, Vazquez, Diana, additional, Wood, Chris, additional, Brown, Claire M., additional, and Guerrero, Adan, additional

Published
2024
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38. Recognising the importance and impact of Imaging Scientists: Global guidelines for establishing career paths within core facilities

Author

Wright, Graham D., primary, Thompson, Kerry A., additional, Reis, Yara, additional, Bischof, Johanna, additional, Hockberger, Philip Edward, additional, Itano, Michelle S., additional, Yen, Lisa, additional, Adelodun, Stephen Taiye, additional, Bialy, Nikki, additional, Brown, Claire M., additional, Chaabane, Linda, additional, Chew, Teng‐Leong, additional, Chitty, Andrew I., additional, Cordelières, Fabrice P., additional, De Niz, Mariana, additional, Ellenberg, Jan, additional, Engelbrecht, Lize, additional, Fabian‐Morales, Eunice, additional, Fazeli, Elnaz, additional, Fernandez‐Rodriguez, Julia, additional, Ferrando‐May, Elisa, additional, Fletcher, Georgina, additional, Galloway, Graham John, additional, Guerrero, Adan, additional, Guimarães, Jander Matos, additional, Jacobs, Caron A., additional, Jayasinghe, Sachintha, additional, Kable, Eleanor, additional, Kitten, Gregory T, additional, Komoto, Shinya, additional, Ma, Xiaoxiao, additional, Marques, Jéssica Araújo, additional, Millis, Bryan A., additional, Miranda, Kildare, additional, JohnO'Toole, Peter, additional, Olatunji, Sunday Yinka, additional, Paina, Federica, additional, Pollak, Cora Noemi, additional, Prats, Clara, additional, Pylvänäinen, Joanna W., additional, Rahmoon, Mai Atef, additional, Reiche, Michael A., additional, Riches, James Douglas, additional, Rossi, Andres Hugo, additional, Salamero, Jean, additional, Thiriet, Caroline, additional, Terjung, Stefan, additional, Vasconcelos, Aldenora dos Santos, additional, and Keppler, Antje, additional

Published
2024
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39. A consensus platform for antibody characterization

Author

Ayoubi, Riham, primary, Ryan, Joel, additional, Bolivar, Sara Gonzalez, additional, Alende, Charles, additional, Moleon, Vera Ruiz, additional, Fotouhi, Maryam, additional, Southern, Kathleen, additional, Alshafie, Walaa, additional, Baker, Matt R, additional, Ball, Alexander R, additional, Callahan, Danielle, additional, Cooper, Jeffery A, additional, Crosby, Katherine, additional, Harvey, Kevin J, additional, Houston, Douglas W, additional, Kumaran, Ravindran, additional, Rego, Meghan, additional, Schofield, Christine, additional, Wu, Hai, additional, Biddle, Michael S, additional, Brown, Claire M, additional, Kahn, Richard A, additional, Bandrowski, Anita, additional, Virk, Harvinder S, additional, Edwards, Aled M, additional, McPherson, Peter S, additional, and Laflamme, Carl, additional

Published
2024
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40. Safety and immunogenicity of heterologous versus homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine (Com-COV): a single-blind, randomised, non-inferiority trial

Author

Munro, Alasdair P S, Bartholomew, Jazz, Presland, Laura, Horswill, Sarah, Warren, Sarah, Varkonyi-Clifford, Sophie, Saich, Stephen, Adams, Kirsty, Ricamara, Marivic, Turner, Nicola, Yee Ting, Nicole Y, Whittley, Sarah, Rampling, Tommy, Desai, Amisha, Brown, Claire H, Qureshi, Ehsaan, Gokani, Karishma, Naker, Kush, Kellett Wright, Johanna K, Williams, Rachel L, Riaz, Tawassal, Penciu, Florentina D, Di Maso, Claudio, Howe, Elizabeth G, Vichos, Iason, Ghulam Farooq, Mujtaba, Noristani, Rabiullah, Yao, Xin L, Oldfield, Neil J, Hammersley, Daniel, Belton, Sue, Royal, Simon, San Francisco Ramos, Alberto, Hultin, Cecilia, Galiza, Eva P, Shiham, Farah, Solórzano, Carla, Sainsbury, Hannah, Davies, Kelly, Ambrose, Pauline, Hitchins, Lisa, Baker, Natalie, Leung, Stephanie, Fothergill, Ross, Godwin, Kerry, Buttigieg, Karen, Shaik, Imam, Brown, Phill, Knight, Chanice, Lall, Paminder, Allen, Lauren, Liu, Xinxue, Shaw, Robert H, Stuart, Arabella S V, Greenland, Melanie, Aley, Parvinder K, Andrews, Nick J, Cameron, J Claire, Charlton, Sue, Clutterbuck, Elizabeth A, Collins, Andrea M, Dinesh, Tanya, England, Anna, Faust, Saul N, Ferreira, Daniela M, Finn, Adam, Green, Christopher A, Hallis, Bassam, Heath, Paul T, Hill, Helen, Lambe, Teresa, Lazarus, Rajeka, Libri, Vincenzo, Long, Fei, Mujadidi, Yama F, Plested, Emma L, Provstgaard-Morys, Samuel, Ramasamy, Maheshi N, Ramsay, Mary, Read, Robert C, Robinson, Hannah, Singh, Nisha, Turner, David P J, Turner, Paul J, Walker, Laura L, White, Rachel, Nguyen-Van-Tam, Jonathan S, and Snape, Matthew D

Published
2021
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44. Can the role of a personal tutor contribute to reducing the undergraduate degree awarding gap for racially minoritised students?

Author

Gabi, Josephine, Braddock, Alison, Brown, Claire, Miller, Denise, Mynott, Gwenda, Jacobi, Melissa, Banerjee, Pallavi, Kenny, Karen, Rawson, Andrew, Gabi, Josephine, Braddock, Alison, Brown, Claire, Miller, Denise, Mynott, Gwenda, Jacobi, Melissa, Banerjee, Pallavi, Kenny, Karen, and Rawson, Andrew

Abstract

The imperative to address the complex problem of degree awarding gaps within UK higher education institutions is multifaceted and messy. Various studies have continually highlighted this persistent undergraduate awarding gap (racial equity gap or/ethnicity gap) between White and racially minoritised students. This disparity in educational outcomes, where racially minoritised students compared to their White counterparts are less likely to graduate with good honours degrees, has gained considerable attention from policymakers and scholars. This underscores the need for comprehensive strategies that transcend conventional approaches and boundaries to achieve systemic change. Efforts to close the awarding gap have predominantly focused on decolonising the curriculum, which is vital. Still, it is also crucial to recognise personal tutoring (PT) as a pivotal and often underestimated role in addressing the awarding gap. The PT role, with its potential to provide a joined-up experience for students, promoting student engagement and enabling them to navigate the ever-changing academic landscape, can be a catalyst for racial equity and an antidote to the degree awarding gap. By reviewing the literature, empirical studies, policy frameworks and practical implementations, this paper sheds light on the diverse ways PT can serve as a potent tool for promoting equity and inclusion and enhancing equitable outcomes for all. Through a synthesis of existing literature and critical analysis, this scoping review highlights ways PT in higher education is conceptualised nationally and internationally and how it can drive transformational change in higher education when aligned with principles of equity.

Published
2024

45. Recognising the importance and impact of Imaging Scientists:Global guidelines for establishing career paths within core facilities

Author

Wright, Graham D., Thompson, Kerry A., Reis, Yara, Bischof, Johanna, Hockberger, Philip Edward, Itano, Michelle S., Yen, Lisa, Adelodun, Stephen Taiye, Bialy, Nikki, Brown, Claire M., Chaabane, Linda, Chew, Teng Leong, Chitty, Andrew I., Cordelières, Fabrice P., De Niz, Mariana, Ellenberg, Jan, Engelbrecht, Lize, Fabian-Morales, Eunice, Fazeli, Elnaz, Fernandez-Rodriguez, Julia, Ferrando-May, Elisa, Fletcher, Georgina, Galloway, Graham John, Guerrero, Adan, Guimarães, Jander Matos, Jacobs, Caron A., Jayasinghe, Sachintha, Kable, Eleanor, Kitten, Gregory T., Komoto, Shinya, Ma, Xiaoxiao, Marques, Jéssica Araújo, Millis, Bryan A., Miranda, Kildare, JohnO'Toole, Peter, Olatunji, Sunday Yinka, Paina, Federica, Pollak, Cora Noemi, Prats, Clara, Pylvänäinen, Joanna W., Rahmoon, Mai Atef, Reiche, Michael A., Riches, James Douglas, Rossi, Andres Hugo, Salamero, Jean, Thiriet, Caroline, Terjung, Stefan, Vasconcelos, Aldenora dos Santos, Keppler, Antje, Wright, Graham D., Thompson, Kerry A., Reis, Yara, Bischof, Johanna, Hockberger, Philip Edward, Itano, Michelle S., Yen, Lisa, Adelodun, Stephen Taiye, Bialy, Nikki, Brown, Claire M., Chaabane, Linda, Chew, Teng Leong, Chitty, Andrew I., Cordelières, Fabrice P., De Niz, Mariana, Ellenberg, Jan, Engelbrecht, Lize, Fabian-Morales, Eunice, Fazeli, Elnaz, Fernandez-Rodriguez, Julia, Ferrando-May, Elisa, Fletcher, Georgina, Galloway, Graham John, Guerrero, Adan, Guimarães, Jander Matos, Jacobs, Caron A., Jayasinghe, Sachintha, Kable, Eleanor, Kitten, Gregory T., Komoto, Shinya, Ma, Xiaoxiao, Marques, Jéssica Araújo, Millis, Bryan A., Miranda, Kildare, JohnO'Toole, Peter, Olatunji, Sunday Yinka, Paina, Federica, Pollak, Cora Noemi, Prats, Clara, Pylvänäinen, Joanna W., Rahmoon, Mai Atef, Reiche, Michael A., Riches, James Douglas, Rossi, Andres Hugo, Salamero, Jean, Thiriet, Caroline, Terjung, Stefan, Vasconcelos, Aldenora dos Santos, and Keppler, Antje

Abstract

In the dynamic landscape of scientific research, imaging core facilities are vital hubs propelling collaboration and innovation at the technology development and dissemination frontier. Here, we present a collaborative effort led by Global BioImaging (GBI), introducing international recommendations geared towards elevating the careers of Imaging Scientists in core facilities. Despite the critical role of Imaging Scientists in modern research ecosystems, challenges persist in recognising their value, aligning performance metrics and providing avenues for career progression and job security. The challenges encompass a mismatch between classic academic career paths and service-oriented roles, resulting in a lack of understanding regarding the value and impact of Imaging Scientists and core facilities and how to evaluate them properly. They further include challenges around sustainability, dedicated training opportunities and the recruitment and retention of talent. Structured across these interrelated sections, the recommendations within this publication aim to propose globally applicable solutions to navigate these challenges. These recommendations apply equally to colleagues working in other core facilities and research institutions through which access to technologies is facilitated and supported. This publication emphasises the pivotal role of Imaging Scientists in advancing research programs and presents a blueprint for fostering their career progression within institutions all around the world.

Published
2024

47. Strengthening the Intersections between Secondary and Tertiary Education in Australia: Building Cultural Capital

Author

Hughes, Katie and Brown, Claire

Abstract

This paper begins by outlining the "education revolution" policy direction of the Australian federal government, and the ways in which it envisages meeting its goal of having a 40% of the population between 25 and 34 with a Bachelor's degree by 2025, and ensuring that 20% of tertiary students come form LSES backgrounds. This is contrasted with the achievements of the UK government's "Widening Participation" strategy. It then discusses the institutional and policy challenges which broad social inclusion goals generate for secondary and tertiary sectors--challenges which are likely to fundamentally reshape both sectors whilst also forcing them to become partners in a national educational mission. The article then examines a framework from the OECD designed to strengthen schools in disadvantaged areas, with disadvantaged students in order that they complete secondary schooling and proceed to tertiary education. In response to the OECD's recommendations, the paper then focuses on one example of a program in which both sectors are collaborating--for mutual benefit--to increase the numbers of LSES students aspiring to and accessing tertiary education and achieving success in tertiary studies, and makes predictions about its future success. This US initiative (AVID) has had significant success for over thirty years and is currently being trialed in a number of Australian schools and universities. It concludes by advocating that schools and universities partner more closely, and that AVID may well be a useful means of achieving this, whilst also enriching schools' cultures and facilitating greater academic success at both university and school, for disadvantaged students.

Published
2014

50. Mouse diet and vendor impact microbiome perturbation and recovery from early-life pulses of amoxicillin.

Author

Curtis-Joseph, Noelle, Peterson, Rachel, Brown, Claire E., Beekman, Chapman, and Belenky, Peter

Subjects
WESTERN diet, GUT microbiome, AMOXICILLIN, STREPTOCOCCACEAE, CLOSTRIDIA
Abstract

The gut microbiome is a dynamic ecosystem shaped by various factors, including diet, sex, and environment. This system plays a crucial role in host health, such that perturbation in the form of antibiotics can lead to a vast array of negative outcomes. Accordingly, a growing body of work seeks to develop interventions to protect the microbiome during antibiotic exposure. While it is well established that antibiotics can disrupt the microbiome in the short term, how the impact of antibiotics is modulated by factors such as diet, sex, and environment is poorly understood. In this study, we analyzed how sex, diet and early life environment (vendor of origin) modulate the impact and recovery of the microbiome in mice treated with oral amoxicillin. Utilizing 16S rRNA gene sequencing and bioinformatic analyses, we looked at the microbiome response to antibiotics under high-sugar and high-fat (Western) and standard high-fiber mouse (Chow) diets in male and female C57BL/6 from Jackson Laboratory, and female mice from Charles River Laboratories. The microbiome composition of each set of mice had a distinct pre-antibiotic starting point, depending on vendor, sex, and diet. These differences were further exacerbated by antibiotic exposure and revealed that each group responded differently to this perturbation. In particular, we found that the Western diet microbiome had an exacerbated response to antibiotics with greater changes in alpha, and beta diversity, and microbial composition when compared to the antibiotic-treated Chow diet cohort. In particular, we detected blooms in Enterobacteriaceae, Streptococcaceae, and Peptostreptococcaceae that were not found in the Chow diet. The response to antibiotics on each diet also appeared to be vendor and sex dependent. Charles River female mice had less Bifidobacteriaceae, Clostridia_UCG.014, and Clostridiaceae compared to Jackson Laboratory females in a Western diet, while female mice had more Bacteroides, Bilophila, and Parasutterella compared to male mice. In a narrow sense, these findings underscore the importance of considering vendor source, diet, and sex when examining antibiotics' impact on mice. The broader implications suggest that we will likely need to utilize patient-specific microbiome-informed approaches in the development of human therapeutics to safeguard the microbiome during antibiotic exposure. [ABSTRACT FROM AUTHOR]

Published
2024
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