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2,250 results on '"Brown, Alan S."'

3. Maternal immune activation: reporting guidelines to improve the rigor, reproducibility, and transparency of the model

Author

Kentner, Amanda C, Bilbo, Staci D, Brown, Alan S, Hsiao, Elaine Y, McAllister, A Kimberley, Meyer, Urs, Pearce, Brad D, Pletnikov, Mikhail V, Yolken, Robert H, and Bauman, Melissa D

Subjects
Biomedical and Clinical Sciences, Neurosciences, Women's Health, Good Health and Well Being, Animals, Consensus, Disease Models, Animal, Female, Neurodevelopmental Disorders, Pregnancy, Prenatal Exposure Delayed Effects, Reproducibility of Results, Research Design, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Biological psychology
Abstract

The 2017 American College of Neuropychopharmacology (ACNP) conference hosted a Study Group on 4 December 2017, Establishing best practice guidelines to improve the rigor, reproducibility, and transparency of the maternal immune activation (MIA) animal model of neurodevelopmental abnormalities. The goals of this session were to (a) evaluate the current literature and establish a consensus on best practices to be implemented in MIA studies, (b) identify remaining research gaps warranting additional data collection and lend to the development of evidence-based best practice design, and (c) inform the MIA research community of these findings. During this session, there was a detailed discussion on the importance of validating immunogen doses and standardizing the general design (e.g., species, immunogenic compound used, housing) of our MIA models both within and across laboratories. The consensus of the study group was that data does not currently exist to support specific evidence-based model selection or methodological recommendations due to lack of consistency in reporting, and that this issue extends to other inflammatory models of neurodevelopmental abnormalities. This launched a call to establish a reporting checklist focusing on validation, implementation, and transparency modeled on the ARRIVE Guidelines and CONSORT (scientific reporting guidelines for animal and clinical research, respectively). Here we provide a summary of the discussions in addition to a suggested checklist of reporting guidelines needed to improve the rigor and reproducibility of this valuable translational model, which can be adapted and applied to other animal models as well.

Published
2019

25. Beyond Attendance: A Multi-Modal Understanding of Arts Participation. Based on the 2008 Survey of Public Participation in the Arts. Research Report #54

Author

National Endowment for the Arts, Novak-Leonard, Jennifer L., and Brown, Alan S.

Abstract

First conducted in 1982, the National Endowment for the Arts' (NEA's) Survey of Public Participation in the Arts (SPPA) serves as the longest-standing resource for studying U.S. adult levels of arts attendance, personal arts creation and performance, and arts participation through electronic media. The environment in which arts organizations function has changed dramatically in the 29 years since the first SPPA. Alternatives for arts and entertainment activities have proliferated, and expectations for personalization and individual control over those experiences have increased. The proliferation of new technologies for interacting with digital content is occurring at a heightened pace, while the nation's demographic characteristics grow increasingly diverse. For arts funders and grantee organizations alike, conferences and meetings have tended to focus on adapting to this new environment. Such discussions often lead to debates over what "arts participation" is and how arts organizations might best channel the myriad pathways through which Americans now engage in artistic and creative expression. Those pathways are blurring in several important respects. Using SPPA data from 1982-2008, this monograph explores the breadth of participation within and between three primary categories, or "modes," of arts activities: arts attendance, personal arts creation and performance, and arts participation through electronic media. In addition, the monograph offers a unique context for understanding arts participation, suggesting that a more expansive framework for the cultural ecology is needed, and discusses implications of the SPPA data and other trends for practice, policy, and future research. Four key contextual factors emerge from the current literature and research; they are crucial to a more comprehensive understanding of arts participation. These four factors are: (1) the skill level of the artist or participant; (2) the form of artistic expression; (3) the setting in which the activity occurs; and (4) the degree to which the individual exercises creative control over the activity. A list of recommended sources, as well as a technical appendix, are included. (Contains 18 tables, 20 figures and 111 notes.)

Published
2011

30. ACC/AATS/AHA/ASE/ASNC/HRS/SCAI/SCCT/SCMR/STS 2019 appropriate use criteria for multimodality imaging in the assessment of cardiac structure and function in nonvalvular heart disease: A report of the American College of Cardiology Appropriate Use Criteria Task Force, American Association for Thoracic Surgery, American Heart Association, American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, and the Society of Thoracic Surgeons

Author

Doherty, John U., Kort, Smadar, Mehran, Roxana, Schoenhagen, Paul, Soman, Prem, Dehmer, Gregory J., Bashore, Thomas M., Bhave, Nicole M., Calnon, Dennis A., Carabello, Blase, Conte, John, Dickfeld, Timm, Edmundowicz, Daniel, Ferrari, Victor A., Hall, Michael E., Ghoshhajra, Brian, Mehrotra, Praveen, Naqvi, Tasneem Z., Reece, T. Brett, Starling, Randall C., Szerlip, Molly, Tzou, Wendy S., Wong, John B., Bailey, Steven R., Brown, Alan S., Daugherty, Stacie L., Dean, Larry S., Desai, Milind Y., Duvernoy, Claire S., Gillam, Linda D., Hendel, Robert C., Kramer, Christopher M., Lindsay, Bruce D., Manning, Warren J., Patel, Manesh R., Sachdeva, Ritu, Wann, L. Samuel, Winchester, David E., and Wolk, Michael J.

Published
2019
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31. ACC/AATS/AHA/ASE/ASNC/SCAI/SCCT/STS 2017 appropriate use criteria for coronary revascularization in patients with stable ischemic heart disease: A report of the American College of Cardiology Appropriate Use Criteria Task Force, American Association for Thoracic Surgery, American Heart Association, American Society of Echocardiography, American Society of Nuclear Cardiology, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, and Society of Thoracic Surgeons

Author

Patel, Manesh R., Calhoon, John H., Dehmer, Gregory J., Grantham, James Aaron, Maddox, Thomas M., Maron, David J., Smith, Peter K., Wolk, Michael J., Blankenship, James C., Bove, Alfred A., Bradley, Steven M., Dean, Larry S., Duffy, Peter L., Ferguson, T. Bruce, Jr, Grover, Frederick L., Guyton, Robert A., Hlatky, Mark A., Lazar, Harold L., Rigolin, Vera H., Rose, Geoffrey A., Shemin, Richard J., Tamis-Holland, Jacqueline E., Tommaso, Carl L., Wann, L. Samuel, Wong, John B., Doherty, John U., Bailey, Steven R., Bhave, Nicole M., Brown, Alan S., Daugherty, Stacie L., Desai, Milind Y., Duvernoy, Claire S., Gillam, Linda D., Hendel, Robert C., Kramer, Christopher M., Lindsay, Bruce D., Manning, Warren J., Sachdeva, Ritu, Winchester, David E., and Allen, Joseph M.

Published
2019
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34. Autobiographical Editing

Author

Brown, Alan S., primary, Fields, Lindy M., additional, Cadero, Katie Croft, additional, Chmielewski, Mike, additional, Denman, Deanna, additional, and Marsh, Elizabeth J., additional

Published
2020
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39. Early Life Programming and Neurodevelopmental Disorders

Author

Bale, Tracy L, Baram, Tallie Z, Brown, Alan S, Goldstein, Jill M, Insel, Thomas R, McCarthy, Margaret M, Nemeroff, Charles B, Reyes, Teresa M, Simerly, Richard B, Susser, Ezra S, and Nestler, Eric J

Subjects
Behavioral and Social Science, Schizophrenia, Neurosciences, Mental Health, Pediatric, Genetics, Obesity, Nutrition, Intellectual and Developmental Disabilities (IDD), Brain Disorders, Metabolic and endocrine, Mental health, Quality Education, Animals, Brain, Disease Models, Animal, Environment, Epigenesis, Genetic, Female, Fetal Development, Gene Expression Regulation, Developmental, Genetic Predisposition to Disease, Humans, Maternal Exposure, Mental Disorders, Sex Factors, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract

For more than a century, clinical investigators have focused on early life as a source of adult psychopathology. Early theories about psychic conflict and toxic parenting have been replaced by more recent formulations of complex interactions of genes and environment. Although the hypothesized mechanisms have evolved, a central notion remains: early life is a period of unique sensitivity during which experience confers enduring effects. The mechanisms for these effects remain almost as much a mystery today as they were a century ago. Recent studies suggest that maternal diet can program offspring growth and metabolic pathways, altering lifelong susceptibility to diabetes and obesity. If maternal psychosocial experience has similar programming effects on the developing offspring, one might expect a comparable contribution to neurodevelopmental disorders, including affective disorders, schizophrenia, autism, and eating disorders. Due to their early onset, prevalence, and chronicity, some of these disorders, such as depression and schizophrenia, are among the highest causes of disability worldwide according to the World Health Organization 2002 report. Consideration of the early life programming and transcriptional regulation in adult exposures supports a critical need to understand epigenetic mechanisms as a critical determinant in disease predisposition. Incorporating the latest insight gained from clinical and epidemiological studies with potential epigenetic mechanisms from basic research, the following review summarizes findings from a workshop on Early Life Programming and Neurodevelopmental Disorders held at the University of Pennsylvania in 2009.

Published
2010

41. The Role of Emotion Regulation, Affect, and Sleep in Individuals With Sleep Bruxism and Those Without: Protocol for a Remote Longitudinal Observational Study

Author

Kreibig, Sylvia D, primary, ten Brink, Maia, additional, Mehta, Ashish, additional, Talmon, Anat, additional, Zhang, Jin-Xiao, additional, Brown, Alan S, additional, Lucas-Griffin, Sawyer S, additional, Axelrod, Ariel K, additional, Manber, Rachel, additional, Lavigne, Gilles J, additional, and Gross, James J, additional

Published
2023
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