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Your search keyword '"Brouwers, Jos F.H.M."' showing total 21 results
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21 results on '"Brouwers, Jos F.H.M."'

7. Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER

Author

Vacaru, Ana M., Tafesse, Fikadu G., Ternes, Philipp, Kondylis, Vangelis, Hermansson, Martin, Brouwers, Jos F.H.M., Somerharju, Pentti, Rabouille, Catherine, and Holthuis, Joost C.M.

Subjects
Ceramides -- Physiological aspects, Homeostasis -- Physiological aspects, Phospholipids -- Physiological aspects, Biological sciences
Abstract

Ceramides are central intermediates of sphingo-lipid metabolism with critical functions in cell organization and survival. They are synthesized on the cytosolic surface of the endoplasmic reticulum (ER) and transported by ceramide transfer protein to the Golgi for conversion to sphingomyelin (SM) by SM synthase SMS1. In this study, we report the identification of an SMS1-related (SMSr) enzyme, which catalyses the synthesis of the SM analogue ceramide phosphoethanolamine (CPE)in the ER lumen. Strikingly, SMSr produces only trace amounts of CPE, i.e., 300-fold less than SMS1-derived SM. Nevertheless, blocking its catalytic activity causes a substantial rise in ER ceramide levels and a structural collapse of the early secretory pathway. We find that the latter phenotype is not caused by depletion of CPE but rather a consequence of ceramide accumulation in the ER. Our results establish SMSr as a key regulator of ceramide homeostasis that seems to operate as a sensor rather than a converter of ceramides in the ER.

Published
2009

16. Aberrant hepatic lipid storage and metabolism in canine portosystemic shunts

Author

Van Den Bossche, Lindsay, Schoonenberg, Vivien A.C., Burgener, Iwan A., Penning, Louis C., Schrall, Ingrid M., Kruitwagen, Hedwig S., Van Wolferen, Monique E., Grinwis, Guy C.M., Kummeling, Anne, Rothuizen, Jan, Van Velzen, Jeroen F., Stathonikos, Nikolas, Molenaar, Martijn R., Helms, Bernd J., Brouwers, Jos F.H.M., Spee, Bart, Van Steenbeek, Frank G., Van Den Bossche, Lindsay, Schoonenberg, Vivien A.C., Burgener, Iwan A., Penning, Louis C., Schrall, Ingrid M., Kruitwagen, Hedwig S., Van Wolferen, Monique E., Grinwis, Guy C.M., Kummeling, Anne, Rothuizen, Jan, Van Velzen, Jeroen F., Stathonikos, Nikolas, Molenaar, Martijn R., Helms, Bernd J., Brouwers, Jos F.H.M., Spee, Bart, and Van Steenbeek, Frank G.

Published
2017

17. Aberrant hepatic lipid storage and metabolism in canine portosystemic shunts

Author

LTI Applied, Van Den Bossche, Lindsay, Schoonenberg, Vivien A.C., Burgener, Iwan A., Penning, Louis C., Schrall, Ingrid M., Kruitwagen, Hedwig S., Van Wolferen, Monique E., Grinwis, Guy C.M., Kummeling, Anne, Rothuizen, Jan, Van Velzen, Jeroen F., Stathonikos, Nikolas, Molenaar, Martijn R., Helms, Bernd J., Brouwers, Jos F.H.M., Spee, Bart, Van Steenbeek, Frank G., LTI Applied, Van Den Bossche, Lindsay, Schoonenberg, Vivien A.C., Burgener, Iwan A., Penning, Louis C., Schrall, Ingrid M., Kruitwagen, Hedwig S., Van Wolferen, Monique E., Grinwis, Guy C.M., Kummeling, Anne, Rothuizen, Jan, Van Velzen, Jeroen F., Stathonikos, Nikolas, Molenaar, Martijn R., Helms, Bernd J., Brouwers, Jos F.H.M., Spee, Bart, and Van Steenbeek, Frank G.

Published
2017

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