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1. Intravenous Thrombolysis Before Endovascular Treatment in Posterior Circulation Occlusions: A MR CLEAN Registry Study

Author: Knapen, Robrecht R.M.M., Pirson, F. Anne V., Langezaal, Lucianne C.M., Brouwer, Josje, Majoie, Charles B.L.M., Emmer, Bart J., Vos, Jan-Albert, van Doormaal, Pieter-Jan, Yoo, Albert J., Bruggeman, Agnetha A.E., Lycklama à Nijeholt, Geert J., van der Leij, Chirstiaan, van Oostenbrugge, Robert J., van Zwam, Wim H., Schonewille, Wouter J., Dippel, Diederik W.J., van der Lugt, Aad, Roos, Yvo B.W.E.M., Boiten, Jelis, Jansen, Ivo G.H., Mulder, Maxim J.H.L., Goldhoorn, Robert-Jan B., Compagne, Kars C.J., Kappelhof, Manon, den Hartog, Sanne J., Hinsenveld, Wouter H., Dippel, Diederik W.J., Roozenbeek, Bob, van der Lugt, Aad, Roos, Yvo B.W.E.M., Wermer, Marieke J.H., van Walderveen, Marianne A.A., van Es, Adriaan C.G.M., Staals, Julie, Hofmeijer, Jeannette, Martens, Jasper M., Boiten, Jelis, de Bruijn, Sebastiaan F., van Dijk, Lukas C., Bart van der Worp, H., Lo, Rob H., van Dijk, Ewoud J., Boogaarts, Hieronymus D., de Vries, J., de Kort, Paul L.M., van Tuijl, Julia, Peluso, Jo P., Fransen, Puck, van den Berg, Jan S.P., van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Uyttenboogaart, Maarten, Eschgi, Omid, Bokkers, Reinoud P.H., Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Keizer, Koos, Yo, Lonneke S.F., den Hertog, Heleen M., Sturm, Emiel J.C., Brouwers, Paul J.A.M., van Walderveen, Marianne A.A., Sprengers, Marieke E.S., Jenniskens, Sjoerd F.M., van den Berg, René, Beenen, Ludo F.M., Postma, Alida A., Roosendaal, Stefan D., van der Kallen, Bas F.W., van den Wijngaard, Ido R., van Es, Adriaan C.G.M., Martens, Jasper M., Yo, Lonneke S.F., Bot, Joost, Meijer, Anton, Ghariq, Elyas, Bokkers, Reinoud P.H., van Proosdij, Marc P., Menno Krietemeijer, G., Peluso, Jo P., Boogaarts, Hieronymus D., Lo, Rob, Dinkelaar, Wouter, Appelman, Auke P.A., Hammer, Bas, Pegge, Sjoert, van der Hoorn, Anouk, Vinke, Saman, Cornelissen, Sandra, Brans, Rutger, Dippel, Diederik W.J., van der Lugt, Aad, Roos, Yvo B.W.E.M., Boiten, Jelis, Hofmeijer, Jeannette, Martens, Jasper M., Bart van der Worp, H., Lo, Rob H., Hofmeijer, Jeannette, Zwenneke Flach, H., Lingsma, Hester F., el Ghannouti, Naziha, Sterrenberg, Martin, Pellikaan, Wilma, Sprengers, Rita, Elfrink, Marjan, Simons, Michelle, Vossers, Marjolein, de Meris, Joke, Vermeulen, Tamara, Geerlings, Annet, van Vemde, Gina, Simons, Tiny, Messchendorp, Gert, Nicolaij, Nynke, Bongenaar, Hester, Bodde, Karin, Kleijn, Sandra, Lodico, Jasmijn, Droste, Hanneke, Wollaert, Maureen, Verheesen, Sabrina, Jeurrissen, D., Bos, Erna, Drabbe, Yvonne, Sandiman, Michelle, Aaldering, Nicoline, Zweedijk, Berber, Vervoort, Jocova, Ponjee, Eva, Romviel, Sharon, Kanselaar, Karin, Barning, Denn, Venema, Esmee, Chalos, Vicky, Geuskens, Ralph R., van Straaten, Tim, Ergezen, Saliha, Harmsma, Roger R.M., Muijres, Daan, de Jong, Anouk, Berkhemer, Olvert A., Boers, Anna M.M., Huguet, J., Groot, P.F.C., Mens, Marieke A., van Kranendonk, Katinka R., Treurniet, Kilian M., Tolhuisen, Manon L., Alves, Heitor, Weterings, Annick J., Kirkels, Eleonora L.F., Voogd, Eva J.H.F., Schupp, Lieve M., Collette, Sabine L., Groot, Adrien E.D., LeCouffe, Natalie E., Konduri, Praneeta R., Prasetya, Haryadi, Arrarte-Terreros, Nerea, Ramos, Lucas A., and Boodt, Nikki
Published: 2024
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2. Prediction of Outcome and Endovascular Treatment Benefit

Author: Venema, Esmee, Roozenbeek, Bob, Mulder, Maxim JHL, Brown, Scott, Majoie, Charles BLM, Steyerberg, Ewout W, Demchuk, Andrew M, Muir, Keith W, Dávalos, Antoni, Mitchell, Peter J, Bracard, Serge, Berkhemer, Olvert A, Lycklama à Nijeholt, Geert J, van Oostenbrugge, Robert J, Roos, Yvo BWEM, van Zwam, Wim H, van der Lugt, Aad, Hill, Michael D, White, Philip, Campbell, Bruce CV, Guillemin, Francis, Saver, Jeffrey L, Jovin, Tudor G, Goyal, Mayank, Dippel, Diederik WJ, Lingsma, Hester F, der Lugt, Aad van, Boiten, Jelis, Vos, Jan Albert, Jansen, Ivo GH, Goldhoorn, Robert-Jan B, Compagne, Kars CJ, Kappelhof, Manon, Brouwer, Josje, den Hartog, Sanne J, Hinsenveld, Wouter H, van Es, Adriaan CGM, Emmer, Bart J, Coutinho, Jonathan M, Schonewille, Wouter J, Wermer, Marieke JH, van Walderveen, Marianne AA, Staals, Julie, Hofmeijer, Jeannette, Martens, Jasper M, de Bruijn, Sebastiaan F, van Dijk, Lukas C, van der Worp, H Bart, Lo, Rob H, van Dijk, Ewoud J, Boogaarts, Hieronymus D, Vries, J de, de Kort, Paul LM, van Tuijl, Julia, Peluso, Jo P, Fransen, Puck, van den Berg, Jan SP, van Hasselt, Boudewijn AAM, Aerden, Leo AM, Dallinga, René J, Uyttenboogaart, Maarten, Eschgi, Omid, Bokkers, Reinoud PH, Schreuder, Tobien HCML, Heijboer, Roel JJ, Keizer, Koos, Yo, Lonneke SF, den Hertog, Heleen M, Bulut, Tomas, Brouwers, Paul JAM, Sprengers, Marieke ES, Jenniskens, Sjoerd FM, van den Berg, René, Yoo, Albert J, Beenen, Ludo FM, Postma, Alida A, Roosendaal, Stefan D, van der Kallen, Bas FW, van den Wijngaard, Ido R, Bot, Joost, van Doormaal, Pieter-Jan, Meijer, Anton, Ghariq, Elyas, van Proosdij, Marc P, Krietemeijer, G Menno, Lo, Rob, Gerrits, Dick, Dinkelaar, Wouter, and Appelman, Auke PA
Subjects: Clinical Trials and Supportive Activities, Clinical Research, Stroke, Brain Disorders, Neurosciences, Aged, Aged, 80 and over, Brain Ischemia, Endovascular Procedures, Humans, Ischemic Stroke, Male, Middle Aged, Registries, Thrombectomy, Treatment Outcome, ischemic stroke, registry, reperfusion, thrombectomy, uncertainty, HERMES collaborators and MR CLEAN Registry Investigators*, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Neurology & Neurosurgery
Abstract: Background and purposeBenefit of early endovascular treatment (EVT) for ischemic stroke varies considerably among patients. The MR PREDICTS decision tool, derived from MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands), predicts outcome and treatment benefit based on baseline characteristics. Our aim was to externally validate and update MR PREDICTS with data from international trials and daily clinical practice.MethodsWe used individual patient data from 6 randomized controlled trials within the HERMES (Highly Effective Reperfusion Evaluated in Multiple Endovascular Stroke Trials) collaboration to validate the original model. Then, we updated the model and performed a second validation with data from the observational MR CLEAN Registry. Primary outcome was functional independence (defined as modified Rankin Scale score 0–2) 3 months after stroke. Treatment benefit was defined as the difference between the probability of functional independence with and without EVT. Discriminative performance was evaluated using a concordance (C) statistic.ResultsWe included 1242 patients from HERMES (633 assigned to EVT, 609 assigned to control) and 3156 patients from the MR CLEAN Registry (all of whom underwent EVT within 6.5 hours). The C-statistic for functional independence was 0.74 (95% CI, 0.72–0.77) in HERMES and, after model updating, 0.80 (0.78–0.82) in the Registry. Median predicted treatment benefit of routinely treated patients (Registry) was 10.3% (interquartile range, 5.8%–14.4%). Patients with low (
Published: 2021

3. Association of thrombus density and endovascular treatment outcomes in patients with acute ischemic stroke due to M1 occlusions

Author: Bruggeman, Agnetha A. E., Aberson, Nyk, Kappelhof, Manon, Dutra, Bruna G., Hoving, Jan W., Brouwer, Josje, Tolhuisen, Manon L., Terreros, Nerea Arrarte, Konduri, Praneeta R., Boodt, Nikki, Roos, Yvo B. W. E. M., van Zwam, Wim H., Bokkers, Reinoud, Martens, Jasper, Marquering, Henk A., Emmer, Bart J., and Majoie, Charles B. L. M.
Published: 2022
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4. Prehospital transdermal glyceryl trinitrate in patients with presumed acute stroke (MR ASAP): an ambulance-based, multicentre, randomised, open-label, blinded endpoint, phase 3 trial

Author: van Ahee, Ayla, Visseren, Frank, Halkes, Patricia, van Eijk, Ruben, Simons, Michelle, Pellikaan, Wilma, Van Wijngaarden, Wilma, Ponjee, Eva, Geijtenbeek, Petra, Arts, Ton, Zock, Elles, Oudshoorn, Wilma, Steenwinkel, Frans, Samim, Hamdia, van Zandwijk, Mark, Vrielink, Lisette, Mulder, Peter Jan, Gerritsen, Aico, Ijzermans, Jim, Kooijman, Marjan, Francissen, Oscar, van Nuland, Rick, van Zwam, Wim, Jacobi, Linda, van den Berg, Rene, Beenen, Ludo, van Es, Adriaan, van Doormaal, Pieter-Jan, Lycklama a Nijeholt, Geert, van den Wijngaard, Ido, Yoo, Albert, Yo, Lonneke, Martens, Jasper, Hammer, Bas, Roosendaal, Stefan, Meijer, Anton, Krietemeijer, Menno, Bokkers, Reinoud, van der Hoorn, Anouk, Gerrits, Dick, Coutinho, Jonathan, Jansen, Ben, Manschot, Sanne, Koudstaal, Peter, Keizer, Koos, Chalos, Vicky, Versteeg, Adriaan, Wolff, Lennard, van Voorst, Henk, van der Sluijs, Matthijs, Hoving, Arnolt-Jan, Treurniet, Kilian, LeCouffe, Natalie, van de Graaf, Rob, Goldhoorn, Robert-Jan, Hinseveld, Wouter, Pirson, Anne, Sondag, Lotte, Kappelhof, Manon, Tolhuisen, Manon, Brouwer, Josje, van der Steen, Wouter, Rinkel, Leon, Bruggeman, Agnetha, Sprengers, Rita, Sterrenberg, Martin, Verheesen, Sabrina, Heiligers, Leontien, Martens, Yvonne, El Ghannouti, Naziha, Slotboom, Miranda, van den Berg, Sophie A, Uniken Venema, Simone M, Reinink, Hendrik, Hofmeijer, Jeannette, Schonewille, Wouter J, Miedema, Irene, Fransen, Puck S S, O Pruissen, D Martijn, Raaijmakers, Theodora W M, van Dijk, Gert W, de Leeuw, Frank-Erik, van Vliet, Jorine A, Kwa, Vincent I H, Kerkhoff, Henk, van 't Net, Alex, Boomars, Rene, Siegers, Arjen, Lok, Tycho, Caminada, Klaartje, Esteve Cuevas, Laura M, Visser, Marieke C, Zwetsloot, Casper P, Boomsma, Jooske M F, Schipper, Mirjam H, van Eijkelenburg, Roeland P J, Berkhemer, Olvert A, Nieboer, Daan, Lingsma, Hester F, Emmer, Bart J, van Oostenbrugge, Robert J, van der Lugt, Aad, Roos, Yvo B W E M, Majoie, Charles B L M, Dippel, Diederik W J, Nederkoorn, Paul J, and van der Worp, H Bart
Published: 2022
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5. Prognostic Value of Thrombus Volume and Interaction With First-Line Endovascular Treatment Device Choice

Author: van Voorst, Henk, Bruggeman, Agnetha A.E., Andriessen, Jurr, Hoving, Jan W., Konduri, Praneeta R., Yang, Wenjin, Kappelhof, Manon, Arrarte Terreros, Nerea, Roos, Yvo B.W.E.M., van Zwam, Wim H., van der Lugt, Aad, van der Hoorn, Anouk, Boiten, Jelis, Roosendaal, Stefan, Jenniskens, Sjoerd, Caan, Matthan W.A., Marquering, Henk A., Emmer, Bart J., Majoie, Charles B.L.M., Dippel, Diederik W.J., van Oostenbrugge, Robert J., Vos, Jan Albert, Jansen, Ivo G.H., Mulder, Maxim J.H.L., Goldhoorn, Robert- Jan B., Compagne, Kars C.J., Brouwer, Josje, den Hartog, Sanne J., Hinsenveld, Wouter H., Dippel, Diederik W.J., Roozenbeek, Bob, van Es, Adriaan C.G.M., Coutinho, Jonathan M., Schonewille, Wouter J., Vos, Jan Albert, Wermer, Marieke J.H., van Walderveen, Marianne A.A., Staals, Julie, van Oostenbrugge, Robert J., Hofmeijer, Jeannette, Martens, Jasper M., Lycklama à Nijeholt, Geert J., de Bruijn, Sebastiaan F., van Dijk, Lukas C., van der Worp, H. Bart, Lo, Rob H., van Dijk, Ewoud J., Boogaarts, Hieronymus D., de Vries, J., de Kort, Paul L.M., van Tuijl, Julia, Peluso, Jo P., Fransen, Puck, van den Berg, Jan S.P., van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Uyttenboogaart, Maarten, Eschgi, Omid, Bokkers, Reinoud P.H., Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Keizer, Koos, Yo, Lonneke S.F., den Hertog, Heleen M., Sturm, Emiel J.C., Brouwers, Paul J.A.M., Lycklama à Nijeholt, Geert J., van Walderveen, Marianne A.A., Sprengers, Marieke E.S., van den Berg, René, Yoo, Albert J., Beenen, Ludo F.M., Postma, Alida A., van der Kallen, Bas F.W., van den Wijngaard, Ido R., van Es, Adriaan C.G.M., Martens, Jasper M., Yo, Lonneke S.F., Vos, Jan Albert, Bot, Joost, van Doormaal, Pieter-Jan, Meijer, Anton, Ghariq, Elyas, Bokkers, Reinoud P.H., van Proosdij, Marc P., Krietemeijer, G. Menno, Peluso, Jo P., Boogaarts, Hieronymus D., Lo, Rob, Gerrits, Dick, Dinkelaar, Wouter, Appelman, Auke P.A., Hammer, Bas, Pegge, Sjoert, Vinke, Saman, Dippel, Diederik W.J., van Oostenbrugge, Robert J., Lycklama à Nijeholt, Geert J., Vos, Jan Albert, Schonewille, Wouter J., Hofmeijer, Jeannette, Martens, Jasper M., van der Worp, H. Bart, Lo, Rob H., van Oostenbrugge, Robert J., Hofmeijer, Jeannette, Flach, H. Zwenneke, Lingsma, Hester F., el Ghannouti, Naziha, Sterrenberg, Martin, Pellikaan, Wilma, Sprengers, Rita, Elfrink, Marjan, Simons, Michelle, Vossers, Marjolein, de Meris, Joke, Vermeulen, Tamara, Geerlings, Annet, van Vemde, Gina, Simons, Tiny, Messchendorp, Gert, Nicolaij, Nynke, Bongenaar, Hester, Bodde, Karin, Kleijn, Sandra, Lodico, Jasmijn, Droste, Hanneke, Wollaert, Maureen, Verheesen, Sabrina, Jeurrissen, D., Bos, Erna, Drabbe, Yvonne, Sandiman, Michelle, Aaldering, Nicoline, Zweedijk, Berber, Vervoort, Jocova, Ponjee, Eva, Romviel, Sharon, Kanselaar, Karin, Barning, Denn, Venema, Esmee, Chalos, Vicky, Geuskens, Ralph R., van Straaten, Tim, Ergezen, Saliha, Harmsma, Roger R.M., Muijres, Daan, de Jong, Anouk, Berkhemer, Olvert A., Boers, Anna M.M., Huguet, J., Groot, P.F.C., Mens, Marieke A., van Kranendonk, Katinka R., Treurniet, Kilian M., Tolhuisen, Manon L., Alves, Heitor, Weterings, Annick J., Kirkels, Eleonora L.F., Voogd, Eva J.H.F., Schupp, Lieve M., Collette, Sabine, Groot, Adrien E.D., LeCouffe, Natalie E., Prasetya, Haryadi, and Ramos, Lucas A.
Published: 2023
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6. Intravenous Thrombolysis Before Endovascular Treatment in Posterior Circulation Occlusions:A MR CLEAN Registry Study

Author: Knapen, Robrecht R.M.M., Pirson, F. Anne V., Langezaal, Lucianne C.M., Brouwer, Josje, Majoie, Charles B.L.M., Emmer, Bart J., Vos, Jan Albert, van Doormaal, Pieter Jan, Yoo, Albert J., Bruggeman, Agnetha A.E., Lycklama À Nijeholt, Geert J., van der Leij, Chirstiaan, van Oostenbrugge, Robert J., van Zwam, Wim H., Schonewille, Wouter J., Knapen, Robrecht R.M.M., Pirson, F. Anne V., Langezaal, Lucianne C.M., Brouwer, Josje, Majoie, Charles B.L.M., Emmer, Bart J., Vos, Jan Albert, van Doormaal, Pieter Jan, Yoo, Albert J., Bruggeman, Agnetha A.E., Lycklama À Nijeholt, Geert J., van der Leij, Chirstiaan, van Oostenbrugge, Robert J., van Zwam, Wim H., and Schonewille, Wouter J.
Abstract: BACKGROUND: The effectiveness of intravenous thrombolysis (IVT) before endovascular treatment (EVT) has been investigated in randomized trials and meta-analyses. These studies mainly concerned anterior circulation occlusions. We aimed to investigate clinical, technical, and safety outcomes of IVT before EVT in posterior circulation occlusions in a nationwide registry. METHODS: Patients were included from the MR CLEAN Registry (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands), a nationwide, prospective, multicenter registry of patients with acute ischemic stroke due to a large intracranial vessel occlusion receiving EVT between 2014 and 2019. All patients with a posterior circulation occlusion were included. Primary outcome was a shift toward better functional outcome on the modified Rankin Scale at 90 days. Secondary outcomes were favorable functional outcome (modified Rankin Scale scores, 0–3), occurrence of symptomatic intracranial hemorrhages, successful reperfusion (extended Thrombolysis in Cerebral Ischemia ≥2B), first-attempt successful reperfusion, and mortality at 90 days. Regression analyses with adjustments based on univariable analyses and literature were applied. RESULTS: A total of 248 patients were included, who received either IVT (n=125) or no IVT (n=123) before EVT. Results show no differences in a shift on the modified Rankin Scale (adjusted common odds ratio, 1.04 [95% CI, 0.61–1.76]). Although symptomatic intracranial hemorrhages occurred more often in the IVT group (4.8% versus 2.4%), regression analysis did not show a significant difference (adjusted odds ratio, 1.65 [95% CI, 0.33–8.35]). Successful reperfusion, favorable functional outcome, first-attempt successful reperfusion, and mortality did not differ between patients treated with and without IVT. CONCLUSIONS: We found no significant differences in clinical, technical, and safety outcomes between patients with a large vessel
Published: 2024

7. Value of Automatically Derived Full Thrombus Characteristics:An Explorative Study of Their Associations with Outcomes in Ischemic Stroke Patients

Author: Mojtahedi, Mahsa, Bruggeman, Agnetha E., van Voorst, Henk, Ponomareva, Elena, Kappelhof, Manon, van der Lugt, Aad, Hoving, Jan W., Dutra, Bruna G., Dippel, Diederik, Cavalcante, Fabiano, Yo, Lonneke, Coutinho, Jonathan, Brouwer, Josje, Treurniet, Kilian, Tolhuisen, Manon L., LeCouffe, Natalie, Arrarte Terreros, Nerea, Konduri, Praneeta R., van Zwam, Wim, Roos, Yvo, Majoie, Charles B.L.M., Emmer, Bart J., Marquering, Henk A., Mojtahedi, Mahsa, Bruggeman, Agnetha E., van Voorst, Henk, Ponomareva, Elena, Kappelhof, Manon, van der Lugt, Aad, Hoving, Jan W., Dutra, Bruna G., Dippel, Diederik, Cavalcante, Fabiano, Yo, Lonneke, Coutinho, Jonathan, Brouwer, Josje, Treurniet, Kilian, Tolhuisen, Manon L., LeCouffe, Natalie, Arrarte Terreros, Nerea, Konduri, Praneeta R., van Zwam, Wim, Roos, Yvo, Majoie, Charles B.L.M., Emmer, Bart J., and Marquering, Henk A.
Abstract: (1) Background: For acute ischemic strokes caused by large vessel occlusion, manually assessed thrombus volume and perviousness have been associated with treatment outcomes. However, the manual assessment of these characteristics is time-consuming and subject to inter-observer bias. Alternatively, a recently introduced fully automated deep learning-based algorithm can be used to consistently estimate full thrombus characteristics. Here, we exploratively assess the value of these novel biomarkers in terms of their association with stroke outcomes. (2) Methods: We studied two applications of automated full thrombus characterization as follows: one in a randomized trial, MR CLEAN-NO IV (n = 314), and another in a Dutch nationwide registry, MR CLEAN Registry (n = 1839). We used an automatic pipeline to determine the thrombus volume, perviousness, density, and heterogeneity. We assessed their relationship with the functional outcome defined as the modified Rankin Scale (mRS) at 90 days and two technical success measures as follows: successful final reperfusion, which is defined as an eTICI score of 2b-3, and successful first-pass reperfusion (FPS). (3) Results: Higher perviousness was significantly related to a better mRS in both MR CLEAN-NO IV and the MR CLEAN Registry. A lower thrombus volume and lower heterogeneity were only significantly related to better mRS scores in the MR CLEAN Registry. Only lower thrombus heterogeneity was significantly related to technical success; it was significantly related to a higher chance of FPS in the MR CLEAN-NO IV trial (OR = 0.55, 95% CI: 0.31–0.98) and successful reperfusion in the MR CLEAN Registry (OR = 0.88, 95% CI: 0.78–0.99). (4) Conclusions: Thrombus characteristics derived from automatic entire thrombus segmentations are significantly related to stroke outcomes.
Published: 2024

8. Improvements in Endovascular Treatment for Acute Ischemic Stroke: A Longitudinal Study in the MR CLEAN Registry

Author: Compagne, Kars C.J., Kappelhof, Manon, Hinsenveld, Wouter H., Brouwer, Josje, Goldhoorn, Robert-Jan B., Uyttenboogaart, Maarten, Bokkers, Reinoud P.H., Schonewille, Wouter J., Martens, Jasper M., Hofmeijer, Jeannette, van der Worp, H. Bart, Lo, Rob T.H., Keizer, Koos, Yo, Lonneke S.F., Lycklama à Nijeholt, Geert J., den Hertog, Heleen M., Sturm, Emiel J.C., Brouwers, Paul J.A.M., van Walderveen, Marianne A.A., Wermer, Marieke J.H., de Bruijn, Sebastiaan F., van Dijk, Lukas C., Boogaarts, Hieronymus D., van Dijk, Ewout J., van Tuijl, Julia H., Peluso, Jo P.P., de Kort, Paul L.M., van Hasselt, Boudewijn A.A.M., Fransen, Puck S., Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Jenniskens, Sjoerd F.M., Sprengers, Marieke E.S., Ghariq, Elias, van den Wijngaard, Ido R., Roosendaal, Stefan D., Meijer, Anton F.J.A., Beenen, Ludo F.M., Postma, Alida A., van den Berg, René, Yoo, Albert J., van Doormaal, Pieter Jan, van Proosdij, Marc P., Krietemeijer, Menno G.M., Gerrits, Dick G., Hammer, Sebastiaan, Vos, Jan Albert, Boiten, Jelis, Coutinho, Jonathan M., Emmer, Bart J., van Es, Ad C.G.M., Roozenbeek, Bob, Roos, Yvo B.W.E.M., van Zwam, Wim H., van Oostenbrugge, Robert J., Majoie, Charles B.L.M., Dippel, Diederik W.J., and van der Lugt, Aad
Published: 2022
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9. Value of Automatically Derived Full Thrombus Characteristics: An Explorative Study of Their Associations with Outcomes in Ischemic Stroke Patients

Author: Mojtahedi, Mahsa, primary, Bruggeman, Agnetha E., additional, van Voorst, Henk, additional, Ponomareva, Elena, additional, Kappelhof, Manon, additional, van der Lugt, Aad, additional, Hoving, Jan W., additional, Dutra, Bruna G., additional, Dippel, Diederik, additional, Cavalcante, Fabiano, additional, Yo, Lonneke, additional, Coutinho, Jonathan, additional, Brouwer, Josje, additional, Treurniet, Kilian, additional, Tolhuisen, Manon L., additional, LeCouffe, Natalie, additional, Arrarte Terreros, Nerea, additional, Konduri, Praneeta R., additional, van Zwam, Wim, additional, Roos, Yvo, additional, Majoie, Charles B. L. M., additional, Emmer, Bart J., additional, and Marquering, Henk A., additional
Published: 2024
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10. Endovascular Thrombectomy in Young Patients With Stroke: A MR CLEAN Registry Study

Author: Brouwer, Josje, Smaal, Johanna A., Emmer, Bart J., de Ridder, Inger R., van den Wijngaard, Ido R., de Leeuw, Frank-Erik, Hofmeijer, Jeannette, van Zwam, Wim H., Martens, Jasper M., Roos, Yvo B.W.E.M., Majoie, Charles B., van Oostenbrugge, Robert J., and Coutinho, Jonathan M.
Published: 2021
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11. Endovascular Treatment for Posterior Circulation Stroke in Routine Clinical Practice: Results of the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands Registry

Author: Pirson, F. Anne V., Boodt, Nikki, Brouwer, Josje, Bruggeman, Agnetha A.E., den Hartog, Sanne J., Goldhoorn, Robert-Jan B., Langezaal, Lucianne C.M., Staals, Julie, van Zwam, Wim H., van der Leij, Christiaan, Brans, Rutger J.B., Majoie, Charles B.L.M., Coutinho, Jonathan M., Emmer, Bart J., Dippel, Diederik W.J., van der Lugt, Aad, Vos, Jan-Albert, van Oostenbrugge, Robert J., and Schonewille, Wouter J.
Published: 2022
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12. Aspiration Versus Stent Retriever Thrombectomy for Posterior Circulation Stroke

Author: Bernsen, Marie Louise E., Bruggeman, Agnetha A.E., Brouwer, Josje, Emmer, Bart J., Majoie, Charles B.L.M., Coutinho, Jonathan M., Goldhoorn, Robert-Jan B., van Oostenbrugge, Robert J., van Zwam, Wim H., van der Leij, Christiaan, Schonewille, Wouter J., Martens, Jasper M., and Hofmeijer, Jeannette
Published: 2022
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13. Occult blood flow patterns distal to an occluded artery in acute ischemic stroke

Author: Arrarte Terreros, Nerea, van Willigen, Bettine G, Niekolaas, Wera S, Tolhuisen, Manon L, Brouwer, Josje, Coutinho, Jonathan M, Beenen, Ludo FM, Majoie, Charles BLM, van Bavel, Ed, and Marquering, Henk A
Published: 2022
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14. Association between thrombus composition and stroke etiology in the MR CLEAN Registry biobank

Author: Hund, Hajo M., Boodt, Nikki, Hansen, Daniel, Haffmans, Willem A., Lycklama à Nijeholt, Geert J., Hofmeijer, Jeannette, Dippel, Diederik W. J., van der Lugt, Aad, van Es, Adriaan C. G. M., van Beusekom, Heleen M. M., Majoie, Charles B. L. M., Roos, Yvo B. W. E. M., van Oostenbrugge, Robert J., van Zwam, Wim H., Boiten, Jelis, Vos, Jan Albert, Jansen, Ivo G. H., Mulder, Maxim J. H. L., Goldhoorn, Robert- Jan B., Compagne, Kars C. J., Kappelhof, Manon, Brouwer, Josje, den Hartog, Sanne J., Hinsenveld, Wouter H., Roozenbeek, Bob, Emmer, Bart J., Coutinho, Jonathan M., Schonewille, Wouter J., Wermer, Marieke J. H., van Walderveen, Marianne A. A., Staals, Julie, Martens, Jasper M., de Bruijn, Sebastiaan F., van Dijk, Lukas C., van der Worp, H. Bart, Lo, Rob H., van Dijk, Ewoud J., Boogaarts, Hieronymus D., de Vries, J., de Kort, Paul L. M., van Tuijl, Julia, Peluso, Jo P., Fransen, Puck, van den Berg, Jan S. P., van Hasselt, Boudewijn A. A. M., Aerden, Leo A. M., Dallinga, René J., Uyttenboogaart, Maarten, Eschgi, Omid, Bokkers, Reinoud P. H., Schreuder, Tobien H. C. M. L., Heijboer, Roel J. J., Keizer, Koos, Yo, Lonneke S. F., den Hertog, Heleen M., Bulut, Tomas, Brouwers, Paul J. A. M., Sprengers, Marieke E. S., Jenniskens, Sjoerd F. M., van den Berg, René, Yoo, Albert J., Beenen, Ludo F. M., Postma, Alida A., Roosendaal, Stefan D., van der Kallen, Bas F. W., van den Wijngaard, Ido R., Bot, Joost, van Doormaal, Pieter-Jan, Meijer, Anton, Ghariq, Elyas, van Proosdij, Marc P., Krietemeijer, G. Menno, Dinkelaar, Wouter, Appelman, Auke P. A., Hammer, Bas, Pegge, Sjoert, van der Hoorn, Anouk, Vinke, Saman, Flach, H. Zwenneke, Lingsma, Hester F., el Ghannouti, Naziha, Sterrenberg, Martin, Pellikaan, Wilma, Sprengers, Rita, Elfrink, Marjan, Simons, Michelle, Vossers, Marjolein, de Meris, Joke, Vermeulen, Tamara, Geerlings, Annet, van Vemde, Gina, Simons, Tiny, Messchendorp, Gert, Nicolaij, Nynke, Bongenaar, Hester, Bodde, Karin, Kleijn, Sandra, Lodico, Jasmijn, Droste, Hanneke, Wollaert, Maureen, Verheesen, Sabrina, Jeurrissen, D., Bos, Erna, Drabbe, Yvonne, Sandiman, Michelle, Aaldering, Nicoline, Zweedijk, Berber, Vervoort, Jocova, Ponjee, Eva, Romviel, Sharon, Kanselaar, Karin, Barning, Denn, Venema, Esmee, Chalos, Vicky, Geuskens, Ralph R., van Straaten, Tim, Ergezen, Saliha, Harmsma, Roger R. M., Muijres, Daan, de Jong, Anouk, Berkhemer, Olvert A., Boers, Anna M. M., Huguet, J., Groot, P. F. C., Mens, Marieke A., van Kranendonk, Katinka R., Treurniet, Kilian M., Tolhuisen, Manon L., Alves, Heitor, Weterings, Annick J., Kirkels, Eleonora L.F., Voogd, Eva J. H. F., Schupp, Lieve M., Collette, Sabine L., Groot, Adrien E. D., LeCouffe, Natalie E., Konduri, Praneeta R., Prasetya, Haryadi, Arrarte-Terreros, Nerea, Ramos, Lucas A., Radiology and Nuclear Medicine, ACS - Microcirculation, ANS - Neurovascular Disorders, Neurology, ACS - Atherosclerosis & ischemic syndromes, ANS - Cellular & Molecular Mechanisms, ANS - Compulsivity, Impulsivity & Attention, Graduate School, Biomedical Engineering and Physics, AMS - Amsterdam Movement Sciences, ANS - Brain Imaging, Adult Psychiatry, APH - Methodology, Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Damage and Repair in Cancer Development and Cancer Treatment (DARE), Cardiology, Radiology & Nuclear Medicine, Radiology and nuclear medicine, Internal medicine, Pediatrics, Amsterdam Neuroscience - Neurovascular Disorders, and CCA - Imaging and biomarkers
Subjects: Microscopy, Ischemic stroke, Radiology, Nuclear Medicine and imaging, Endovascular treatment, Neurology (clinical), Cardiology and Cardiovascular Medicine, Mechanical thrombectomy, Stent-retriever, Thrombus
Abstract: Purpose The composition of thrombi retrieved during endovascular thrombectomy (EVT) in acute ischemic stroke (AIS) due to large vessel occlusion (LVO) may differ depending on their origin. In this study, we investigated the association between thrombus composition and stroke etiology in a large population of patients from the Dutch MR CLEAN Registry treated with EVT in daily clinical practice. Methods The thrombi of 332 patients with AIS were histologically analyzed for red blood cells (RBC), fibrin/platelets (F/P), and white blood cells (leukocytes) using a machine learning algorithm. Stroke etiology was assessed using the Trial of Org 10,172 in acute stroke treatment (TOAST) classification. Results The thrombi of cardioembolic origin contained less RBC and more F/P than those of non-cardioembolic origin (25.8% vs 41.2% RBC [p = 0.003] and 67.1% vs 54.5% F/P [p = 0.004]). The likelihood of a non-cardioembolic source of stroke increased with increasing thrombus RBC content (OR 1.02; [95% CI 1.00–1.06] for each percent increase) and decreased with a higher F/P content (OR 1.02; [95% CI 1.00–1.06]). Thrombus composition in patients with a cardioembolic origin and undetermined origin was similar. Conclusion Thrombus composition is significantly associated with stroke etiology, with an increase in RBC and a decrease in F/P raising the odds for a non-cardioembolic cause. No difference between composition of cardioembolic thrombi and of undetermined origin was seen. This emphasizes the need for more extensive monitoring for arrhythmias and/or extended cardiac analysis in case of an undetermined origin.
Published: 2023
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15. Validity of Early Outcomes as Indicators for Comparing Hospitals on Quality of Stroke Care

Author: Amini, Marzyeh, primary, Eijkenaar, Frank, additional, Lingsma, Hester F., additional, den Hartog, Sanne J., additional, Olthuis, Susanne G. H., additional, Martens, Jasper, additional, van der Worp, Bart, additional, van Zwam, Wim, additional, van der Hoorn, Anouk, additional, Roosendaal, Stefan D., additional, Roozenbeek, Bob, additional, Dippel, Diederik, additional, van Leeuwen, Nikki, additional, Dippel, Diederik W. J., additional, van der Lugt, Aad, additional, Majoie, Charles B. L. M., additional, Roos, Yvo B. W. E. M., additional, van Oostenbrugge, Robert J., additional, van Zwam, Wim H., additional, Boiten, Jelis, additional, Vos, Jan Albert, additional, Brouwer, Josje, additional, Hinsenveld, Wouter H., additional, Kappelhof, Manon, additional, Compagne, Kars C. J., additional, Goldhoorn, Robert‐Jan B., additional, Mulder, Maxim J. H. L., additional, Jansen, Ivo G. H., additional, van Es, Adriaan C. G. M., additional, Emmer, Bart J., additional, Coutinho, Jonathan M., additional, Schonewille, Wouter J., additional, Wermer, Marieke J. H., additional, van Walderveen, Marianne A. A., additional, Staals, Julie, additional, Hofmeijer, Jeannette, additional, Martens, Jasper M., additional, Lycklama à Nijeholt, Geert J., additional, de Bruijn, Sebastiaan F., additional, van Dijk, Lukas C., additional, van der Worp, H. Bart, additional, Lo, Rob H., additional, van Dijk, Ewoud J., additional, Boogaarts, Hieronymus D., additional, de Vries, J., additional, de Kort, Paul L. M., additional, van Tuijl, Julia, additional, Peluso, Jo Jo P., additional, Fransen, Puck, additional, van den Berg, Jan S. P., additional, van Hasselt, Boudewijn A. A. M., additional, Aerden, Leo A. M., additional, Dallinga, René J., additional, Uyttenboogaart, Maarten, additional, Eschgi, Omid, additional, Bokkers, Reinoud P. H., additional, Schreuder, Tobien H. C. M. L., additional, Heijboer, Roel J. J., additional, Keizer, Koos, additional, Yo, Lonneke S. F., additional, den Hertog, Heleen M., additional, Sturm, Emiel J. C., additional, Brouwers, Paul, additional, Sprengers, Marieke E. S., additional, Jenniskens, Sjoerd F. M., additional, van den Berg, René, additional, Yoo, Albert J., additional, Beenen, Ludo F. M., additional, Postma, Alida A., additional, van der Kallen, Bas F. W., additional, van den Wijngaard, Ido R., additional, Bot, Joost, additional, van Doormaal, Pieter‐Jan, additional, Meijer, Anton, additional, Ghariq, Elyas, additional, van Proosdij, Marc P., additional, Krietemeijer, G. Menno, additional, Peluso, Jo P., additional, Lo, Rob, additional, Dinkelaar, Wouter, additional, Appelman, Auke P. A., additional, Hammer, Bas, additional, Pegge, Sjoert, additional, Vinke, Saman, additional, Flach, H. Zwenneke, additional, el Ghannouti, Naziha, additional, Sterrenberg, Martin, additional, Puppels, Corina, additional, Pellikaan, Wilma, additional, Sprengers, Rita, additional, Elfrink, Marjan, additional, Simons, Michelle, additional, Vossers, Marjolein, additional, de Meris, Joke, additional, Vermeulen, Tamara, additional, Geerlings, Annet, additional, van Vemde, Gina, additional, Simons, Tiny, additional, van Rijswijk, Cathelijn, additional, Messchendorp, Gert, additional, Nicolaij, Nynke, additional, Bongenaar, Hester, additional, Bodde, Karin, additional, Kleijn, Sandra, additional, Lodico, Jasmijn, additional, Droste, Hanneke, additional, Wollaert, Maureen, additional, Verheesen, Sabrina, additional, Jeurrissen, D., additional, Bos, Erna, additional, Drabbe, Yvonne, additional, Sandiman, Michelle, additional, Aaldering, Nicoline, additional, Zweedijk, Berber, additional, Khalilzada, Mostafa, additional, Vervoort, Jocova, additional, Ponjee, Eva, additional, Romviel, Sharon, additional, Kanselaar, Karin, additional, Barning, Denn, additional, Venema, Esmee, additional, Chalos, Vicky, additional, Geuskens, Ralph R., additional, van Straaten, Tim, additional, Ergezen, Saliha, additional, Harmsma, Roger R. M., additional, Muijres, Daan, additional, de Jong, Anouk, additional, Berkhemer, Olvert A., additional, Boers, Anna M. M., additional, Huguet, J., additional, Groot, P. F. C., additional, Mens, Marieke A., additional, van Kranendonk, Katinka R., additional, Treurniet, Kilian M., additional, Tolhuisen, Manon L., additional, Alves, Heitor, additional, Weterings, Annick J., additional, Kirkels, Eleonora L. F., additional, Voogd, Eva J. H. F., additional, Schupp, Lieve M., additional, Collette, Sabine, additional, Groot, Adrien E. D., additional, LeCouffe, Natalie E., additional, Konduri, Praneeta R., additional, Prasetya, Haryadi, additional, Arrarte‐Terreros, Nerea, additional, and Ramos, Lucas A., additional
Published: 2023
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16. Endovascular treatment for isolated posterior cerebral artery occlusion stroke in the MR CLEAN registry

Author: Stroke, Neurologen, Circulatory Health, Brain, MS Radiologie, Brouwer, Josje, Ergezen, Saliha, Mulder, Maxim Johan Heymen Laurence, Lycklama A Nijeholt, Geert J, van Es, Adriaan C G M, van der Lugt, Aad, Dippel, Diederik W J, Majoie, Charles B L M, Roos, Yvo B W E M, Coutinho, J M, Emmer, Bart J, MR CLEAN Registry Investigators, van der worp, B, Lo, Rob, Zweedijk, Berber, Stroke, Neurologen, Circulatory Health, Brain, MS Radiologie, Brouwer, Josje, Ergezen, Saliha, Mulder, Maxim Johan Heymen Laurence, Lycklama A Nijeholt, Geert J, van Es, Adriaan C G M, van der Lugt, Aad, Dippel, Diederik W J, Majoie, Charles B L M, Roos, Yvo B W E M, Coutinho, J M, Emmer, Bart J, MR CLEAN Registry Investigators, van der worp, B, Lo, Rob, and Zweedijk, Berber
Published: 2023

17. Endovascular treatment for isolated posterior cerebral artery occlusion stroke in the MR CLEAN registry

Author: Brouwer, Josje, Ergezen, Saliha, Mulder, Maxim Johan Heymen Laurence, Nijeholt, Geert J.Lycklama A., Van Es, Adriaan C.G.M., Van Der Lugt, Aad, Dippel, Diederik W.J., Majoie, Charles B.L.M., Roos, Yvo B.W.E.M., Coutinho, J. M., Emmer, Bart J., Van Oostenbrugge, Robert J., Van Zwam, Wim H., Boiten, Jelis, Vos, Jan Albert, Jansen, Ivo G.H., Goldhoorn, Robert Jan B., Compagne, Kars C.J., Kappelhof, Manon, Den Hartog, Sanne J., Hinsenveld, Wouter H., Roozenbeek, Bob, Schonewille, Wouter J., Wermer, Marieke J.H., Van Walderveen, Marianne A.A., Staals, Julie, Hofmeijer, Jeannette, Martens, Jasper M., De Bruijn, Sebastiaan F., Van Dijk, Lukas C., Van Der Worp, H. Bart, Lo, Rob H., Van Dijk, Ewoud J., Boogaarts, Hieronymus D., De Vries, J., De Kort, Paul L.M., Van Tuijl, Julia, Peluso, Jo P., Fransen, Puck, Van Den Berg, Jan S.P., Van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Uyttenboogaart, Maarten, Eschgi, Omid, Bokkers, Reinoud P.H., Schreuder, Tobien H.C.M.L., Postma, Alida A., Van Der Leij, Christiaan, Brans, Rutger, Pirson, Anne-France, MR CLEAN Registry Investigators, Brouwer, Josje, Ergezen, Saliha, Mulder, Maxim Johan Heymen Laurence, Nijeholt, Geert J.Lycklama A., Van Es, Adriaan C.G.M., Van Der Lugt, Aad, Dippel, Diederik W.J., Majoie, Charles B.L.M., Roos, Yvo B.W.E.M., Coutinho, J. M., Emmer, Bart J., Van Oostenbrugge, Robert J., Van Zwam, Wim H., Boiten, Jelis, Vos, Jan Albert, Jansen, Ivo G.H., Goldhoorn, Robert Jan B., Compagne, Kars C.J., Kappelhof, Manon, Den Hartog, Sanne J., Hinsenveld, Wouter H., Roozenbeek, Bob, Schonewille, Wouter J., Wermer, Marieke J.H., Van Walderveen, Marianne A.A., Staals, Julie, Hofmeijer, Jeannette, Martens, Jasper M., De Bruijn, Sebastiaan F., Van Dijk, Lukas C., Van Der Worp, H. Bart, Lo, Rob H., Van Dijk, Ewoud J., Boogaarts, Hieronymus D., De Vries, J., De Kort, Paul L.M., Van Tuijl, Julia, Peluso, Jo P., Fransen, Puck, Van Den Berg, Jan S.P., Van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Uyttenboogaart, Maarten, Eschgi, Omid, Bokkers, Reinoud P.H., Schreuder, Tobien H.C.M.L., Postma, Alida A., Van Der Leij, Christiaan, Brans, Rutger, Pirson, Anne-France, and MR CLEAN Registry Investigators
Abstract: Background Endovascular treatment (EVT) is standard of care in anterior circulation large vessel occlusions. In posterior circulation occlusions, data on EVT in isolated posterior cerebral artery (PCA) occlusions are limited, although PCA occlusions can cause severe neurological deficit. Objective To describe in a prospective study the clinical manifestations, outcomes, and safety of EVT in isolated PCA occlusions. Methods We used data (2014-2017) from the MR CLEAN Registry, a nationwide, prospective cohort of EVT-treated patients in the Netherlands. We included patients with acute ischemic stroke (AIS) due to an isolated PCA occlusion on CT angiography. Patients with concurrent occlusion of the basilar artery were excluded. Outcomes included change in National Institutes of Health Stroke Scale (?NIHSS) score, modified Rankin Scale (mRS) score 0-3 after 90 days, mortality, expanded Thrombolysis in Cerebral Infarction (eTICI), and periprocedural complications. Results Twenty (12%) of 162 patients with posterior circulation occlusions had an isolated PCA occlusion. Median age was 72 years; 13 (65%) were women. Median baseline NIHSS score was 13 (IQR 5-21). Six (30%) patients were comatose. Twelve patients (60%) received IVT. Median ?NIHSS was -4 (IQR -11-+1). At follow-up, nine patients (45%) had mRS score 0-3. Seven (35%) died. eTICI 2b-3 was achieved in 13 patients (65%). Nine patients (45%) had periprocedural complications. No symptomatic intracranial hemorrhages (sICH) occurred. Conclusions EVT should be considered in selected patients with AIS with an isolated PCA occlusion, presenting with moderate-severe neurological deficits, as EVT was technically feasible in most of our patients and about half had good clinical outcome. In case of lower NIHSS score, a more conservative approach seems warranted, since periprocedural complications are not uncommon. Nonetheless, EVT seems reasonably safe considering the absence of sICH in our study.
Published: 2023

18. Prognostic Value of Thrombus Volume and Interaction With First-Line Endovascular Treatment Device Choice

Author: Neurologen, Brain, Circulatory Health, Stroke, MS Radiologie, Van Voorst, Henk, Bruggeman, Agnetha A.E., Andriessen, Jurr, Hoving, Jan W., Konduri, Praneeta R., Yang, Wenjin, Kappelhof, Manon, Arrarte Terreros, Nerea, Roos, Yvo B.W.E.M., Van Zwam, Wim H., Van Der Lugt, Aad, Van Der Hoorn, Anouk, Boiten, Jelis, Roosendaal, Stefan, Jenniskens, Sjoerd, Caan, Matthan W.A., Marquering, Henk A., Emmer, Bart J., Majoie, Charles B.L.M., Dippel, Diederik W.J., Van Oostenbrugge, Robert J., Vos, Jan Albert, Jansen, Ivo G.H., Mulder, Maxim J.H.L., Goldhoorn, Robert Jan B., Compagne, Kars C.J., Brouwer, Josje, Den Hartog, Sanne J., Hinsenveld, Wouter H., Roozenbeek, Bob, Van Es, Adriaan C.G.M., Coutinho, Jonathan M., Schonewille, Wouter J., Wermer, Marieke J.H., Van Walderveen, Marianne A.A., Staals, Julie, Hofmeijer, Jeannette, Martens, Jasper M., Lycklama À Nijeholt, Geert J., De Bruijn, Sebastiaan F., Van Dijk, Lukas C., Van Der Worp, H. Bart, Lo, Rob H., Van Dijk, Ewoud J., Boogaarts, Hieronymus D., De Vries, J., De Kort, Paul L.M., Van Tuijl, Julia, Peluso, Jo P., Fransen, Puck, Van Den Berg, Jan S.P., Van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Uyttenboogaart, Maarten, Eschgi, Omid, Bokkers, Reinoud P.H., Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Keizer, Koos, Yo, Lonneke S.F., Den Hertog, Heleen M., Sturm, Emiel J.C., Brouwers, Paul J.A.M., Sprengers, Marieke E.S., Van Den Berg, René, Yoo, Albert J., Beenen, Ludo F.M., Postma, Alida A., Van Der Kallen, Bas F.W., Van Den Wijngaard, Ido R., Bot, Joost, Van Doormaal, Pieter Jan, Meijer, Anton, Ghariq, Elyas, Van Proosdij, Marc P., Krietemeijer, G. Menno, Gerrits, Dick, Dinkelaar, Wouter, Appelman, Auke P.A., Hammer, Bas, Pegge, Sjoert, Vinke, Saman, Flach, H. Zwenneke, Lingsma, Hester F., El Ghannouti, Naziha, Sterrenberg, Martin, Pellikaan, Wilma, Sprengers, Rita, Elfrink, Marjan, Simons, Michelle, Vossers, Marjolein, De Meris, Joke, Vermeulen, Tamara, Geerlings, Annet, Van Vemde, Gina, Simons, Tiny, Messchendorp, Gert, Nicolaij, Nynke, Bongenaar, Hester, Bodde, Karin, Kleijn, Sandra, Lodico, Jasmijn, Droste, Hanneke, Wollaert, Maureen, Verheesen, Sabrina, Jeurrissen, D., Bos, Erna, Drabbe, Yvonne, Sandiman, Michelle, Aaldering, Nicoline, Zweedijk, Berber, Vervoort, Jocova, Ponjee, Eva, Romviel, Sharon, Kanselaar, Karin, Barning, Denn, Venema, Esmee, Chalos, Vicky, Geuskens, Ralph R., Van Straaten, Tim, Ergezen, Saliha, Harmsma, Roger R.M., Muijres, Daan, De Jong, Anouk, Berkhemer, Olvert A., Boers, Anna M.M., Huguet, J., Groot, P. F.C., Mens, Marieke A., Van Kranendonk, Katinka R., Treurniet, Kilian M., Tolhuisen, Manon L., Alves, Heitor, Weterings, Annick J., Kirkels, Eleonora L.F., Voogd, Eva J.H.F., Schupp, Lieve M., Collette, Sabine, Groot, Adrien E.D., Lecouffe, Natalie E., Prasetya, Haryadi, Ramos, Lucas A., Neurologen, Brain, Circulatory Health, Stroke, MS Radiologie, Van Voorst, Henk, Bruggeman, Agnetha A.E., Andriessen, Jurr, Hoving, Jan W., Konduri, Praneeta R., Yang, Wenjin, Kappelhof, Manon, Arrarte Terreros, Nerea, Roos, Yvo B.W.E.M., Van Zwam, Wim H., Van Der Lugt, Aad, Van Der Hoorn, Anouk, Boiten, Jelis, Roosendaal, Stefan, Jenniskens, Sjoerd, Caan, Matthan W.A., Marquering, Henk A., Emmer, Bart J., Majoie, Charles B.L.M., Dippel, Diederik W.J., Van Oostenbrugge, Robert J., Vos, Jan Albert, Jansen, Ivo G.H., Mulder, Maxim J.H.L., Goldhoorn, Robert Jan B., Compagne, Kars C.J., Brouwer, Josje, Den Hartog, Sanne J., Hinsenveld, Wouter H., Roozenbeek, Bob, Van Es, Adriaan C.G.M., Coutinho, Jonathan M., Schonewille, Wouter J., Wermer, Marieke J.H., Van Walderveen, Marianne A.A., Staals, Julie, Hofmeijer, Jeannette, Martens, Jasper M., Lycklama À Nijeholt, Geert J., De Bruijn, Sebastiaan F., Van Dijk, Lukas C., Van Der Worp, H. Bart, Lo, Rob H., Van Dijk, Ewoud J., Boogaarts, Hieronymus D., De Vries, J., De Kort, Paul L.M., Van Tuijl, Julia, Peluso, Jo P., Fransen, Puck, Van Den Berg, Jan S.P., Van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Uyttenboogaart, Maarten, Eschgi, Omid, Bokkers, Reinoud P.H., Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Keizer, Koos, Yo, Lonneke S.F., Den Hertog, Heleen M., Sturm, Emiel J.C., Brouwers, Paul J.A.M., Sprengers, Marieke E.S., Van Den Berg, René, Yoo, Albert J., Beenen, Ludo F.M., Postma, Alida A., Van Der Kallen, Bas F.W., Van Den Wijngaard, Ido R., Bot, Joost, Van Doormaal, Pieter Jan, Meijer, Anton, Ghariq, Elyas, Van Proosdij, Marc P., Krietemeijer, G. Menno, Gerrits, Dick, Dinkelaar, Wouter, Appelman, Auke P.A., Hammer, Bas, Pegge, Sjoert, Vinke, Saman, Flach, H. Zwenneke, Lingsma, Hester F., El Ghannouti, Naziha, Sterrenberg, Martin, Pellikaan, Wilma, Sprengers, Rita, Elfrink, Marjan, Simons, Michelle, Vossers, Marjolein, De Meris, Joke, Vermeulen, Tamara, Geerlings, Annet, Van Vemde, Gina, Simons, Tiny, Messchendorp, Gert, Nicolaij, Nynke, Bongenaar, Hester, Bodde, Karin, Kleijn, Sandra, Lodico, Jasmijn, Droste, Hanneke, Wollaert, Maureen, Verheesen, Sabrina, Jeurrissen, D., Bos, Erna, Drabbe, Yvonne, Sandiman, Michelle, Aaldering, Nicoline, Zweedijk, Berber, Vervoort, Jocova, Ponjee, Eva, Romviel, Sharon, Kanselaar, Karin, Barning, Denn, Venema, Esmee, Chalos, Vicky, Geuskens, Ralph R., Van Straaten, Tim, Ergezen, Saliha, Harmsma, Roger R.M., Muijres, Daan, De Jong, Anouk, Berkhemer, Olvert A., Boers, Anna M.M., Huguet, J., Groot, P. F.C., Mens, Marieke A., Van Kranendonk, Katinka R., Treurniet, Kilian M., Tolhuisen, Manon L., Alves, Heitor, Weterings, Annick J., Kirkels, Eleonora L.F., Voogd, Eva J.H.F., Schupp, Lieve M., Collette, Sabine, Groot, Adrien E.D., Lecouffe, Natalie E., Prasetya, Haryadi, and Ramos, Lucas A.
Published: 2023

19. Effect of Intravenous Alteplase Treatment on First-Line Stent Retriever Versus Aspiration Alone During Endovascular Treatment

Author: Rinkel, Leon A., primary, Treurniet, Kilian M., additional, Nieboer, Daan, additional, Kappelhof, Manon, additional, LeCouffe, Natalie E., additional, Bruggeman, Agnetha A.E., additional, van Zwam, Wim H., additional, Lycklama à Nijeholt, Geert J., additional, Ghariq, Elyas, additional, Uyttenboogaart, Maarten, additional, Dippel, Diederik W.J., additional, Roos, Yvo B.W.E.M., additional, Coutinho, Jonathan M., additional, Majoie, Charles B.L.M., additional, Emmer, Bart J., additional, Roozenbeek, Bob, additional, van Es, Adriaan, additional, de Ridder, Inger, additional, van der Worp, Bart, additional, Lo, Rob, additional, Keizer, Koos, additional, Gons, Rob, additional, Yo, Lonneke, additional, Boiten, Jelis, additional, van den Wijngaard, Ido, additional, Hofmeijer, Jeanette, additional, Martens, Jasper, additional, Schonewille, Wouter, additional, Albert Vos, Jan, additional, Tuladhar, Anil, additional, Schreuder, Floris, additional, Boogaarts, Jeroen, additional, Jenniskens, Sjoerd, additional, de Laat, Karlijn, additional, van Dijk, Lukas, additional, den Hertog, Heleen, additional, van Hasselt, Boudewijn, additional, Brouwers, Paul, additional, Sturm, Emiel, additional, Bulut, Tomas, additional, Remmers, Michel, additional, van Norden, Anouk, additional, de Jong, Thijs, additional, Rozeman, Anouk, additional, Elgersma, Otto, additional, Bokkers, Reinoud, additional, van Tuijl, Julia, additional, Boukrab, Issam, additional, Kortman, Hans, additional, Costalat, Vincent, additional, Arquizan, Caroline, additional, Lemmens, Robin, additional, Demeestere, Jelle, additional, Desfontaines, Philippe, additional, Brisbois, Denis, additional, Clarençon, Frédéric, additional, Samson, Yves, additional, Brown, Martin, additional, White, Phil, additional, Gregson, John, additional, van Nuland, Rick, additional, van der Lugt, Aad, additional, Jacobi, Linda, additional, van den Berg, René, additional, Beenen, Ludo, additional, van Doormaal, Pieter-Jan, additional, Yoo, Albert, additional, Hammer, Bas, additional, Roosendaal, Stefan, additional, Meijer, Anton, additional, Krietemeijer, Menno, additional, van der Hoorn, Anouk, additional, Gerrits, Dick, additional, van Oostenbrugge, Robert, additional, Jansen, Ben, additional, Manschot, Sanne, additional, Kerkhof, Henk, additional, Koudstaal, Peter, additional, Lingsma, Hester, additional, Chalos, Vicky, additional, Berkhemer, Olvert, additional, Versteeg, Adriaan, additional, Wolff, Lennard, additional, Su, Jiahang, additional, Tolhuisen, Manon, additional, van Voorst, Henk, additional, ten Cate, Hugo, additional, de Maat, Moniek, additional, Donse-Donkel, Samantha, additional, van Beusekom, Heleen, additional, Taha, Aladdin, additional, van den Berg, Sophie, additional, van de Graaf, Rob, additional, Goldhoorn, Robert-Jan, additional, Hinsenveld, Wouter, additional, Pirson, Anne, additional, Sondag, Lotte, additional, Reinink, Rik, additional, Brouwer, Josje, additional, Collette, Sabine, additional, van der Steen, Wouter, additional, Sprengers, Rita, additional, Sterrenberg, Martin, additional, El Ghannouti, Naziha, additional, Verheesen, Sabrina, additional, Pellikaan, Wilma, additional, Blauwendraat, Kitty, additional, Drabbe, Yvonne, additional, de Meris, Joke, additional, Simons, Michelle, additional, Bongenaar, Hester, additional, van Loon, Anja, additional, Ponjee, Eva, additional, Eilander, Rieke, additional, Kooij, Suze, additional, de Jong, Marieke, additional, Santegoets, Esther, additional, Roodenburg, Suze, additional, van Ahee, Ayla, additional, Moynier, Marinette, additional, Devroye, Annemie, additional, Marcis, Evelyn, additional, Iezzi, Ingrid, additional, David, Annie, additional, Talbi, Atika, additional, Heiligers, Leontien, additional, and Martens, Yvonne, additional
Published: 2022
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20. Thrombus radiomics in patients with anterior circulation acute ischemic stroke undergoing endovascular treatment.

Author: van Voorst, Henk, Bruggeman, Agnetha A. E., Wenjin Yang, Andriessen, Jurr, Welberg, Elise, Dutra, Bruna G., Konduri, Praneeta R., Terreros, Nerea Arrarte, Hoving, Jan W., Tolhuisen, Manon L., Kappelhof, Manon, Brouwer, Josje, Boodt, Nikki, van Kranendonk, Katinka R., Koopman, Miou S., Hund, Hajo M., Krietemeijer, Menno, van Zwam, Wim H., van Beusekom, Heleen M. M., and van der Lugt, Aad
Subjects: THROMBOSIS surgery, THROMBOSIS, PILOT projects, CONFIDENCE intervals, ISCHEMIC stroke, FUNCTIONAL status, MAGNETIC resonance imaging, DESCRIPTIVE statistics, RESEARCH funding, COMPUTED tomography, ENDOVASCULAR surgery, REPERFUSION, LOGISTIC regression analysis
Abstract: Background Thrombus radiomics (TR) describe complex shape and textural thrombus imaging features. We aimed to study the relationship of TR extracted from non-contrast CT with procedural and functional outcome in endovasculartreated patients with acute ischemic stroke. Methods Thrombi were segmented on thin-slice noncontrast CT (≤1 mm) from 699 patients included in the MR CLEAN Registry. In a pilot study, we selected 51 TR with consistent values across two raters' segmentations (ICC >0.75). Random forest models using TR in addition or as a substitute to baseline clinical variables (CV) and manual thrombus measurements (MTM) were trained with 499 patients and evaluated on 200 patients for predicting successful reperfusion (extended Thrombolysis in Cerebral Ischemia (eTICI) ≥2B), first attempt reperfusion, reperfusion within three attempts, and functional independence (modified Rankin Scale (mRS) ≤2). Three texture and shape features were selected based on feature importance and related to eTICI ≥2B, number of attempts to eTICI ≥2B, and 90-day mRS with ordinal logistic regression. Results Random forest models using TR, CV or MTM had comparable predictive performance. Thrombus texture (inverse difference moment normalized) was independently associated with reperfusion (adjusted common OR (acOR) 0.85, 95% CI 0.72 to 0.99). Thrombus volume and texture were also independently associated with the number of attempts to successful reperfusion (acOR 1.36, 95% CI 1.03 to 1.88 and acOR 1.24, 95% CI 1.04 to 1.49). Conclusions TR describing thrombus volume and texture were associated with more attempts to successful reperfusion. Compared with models using CV and MTM, TR had no added value for predicting procedural and functional outcome. [ABSTRACT FROM AUTHOR]
Published: 2023
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21. Thrombus imaging characteristics within acute ischemic stroke: similarities and interdependence.

Author: Terreros, Nerea Arrarte, Bruggeman, Agnetha A. E., Kappelhof, Manon, Tolhuisen, Manon L., Brouwer, Josje, Hoving, Jan W., Konduri, Praneeta R., van Kranendonk, Katinka R., Dutra, Bruna G., Alves, Heitor C. B. R., Dippel, Diederik W. J., van Zwam, Wim H., Beenen, Ludo F. M., Yo, Lonneke S. F., van Bavel, Ed, Majoie, Charles B. L. M., and Marquering, Henk A.
Subjects: REPORTING of diseases, CAROTID artery, STATISTICS, ISCHEMIC stroke, CEREBRAL circulation, DIAGNOSTIC imaging, SEVERITY of illness index, TREATMENT effectiveness, DATABASE management, RESEARCH funding, DESCRIPTIVE statistics, CAROTID artery thrombosis, DATA analysis, CLUSTER analysis (Statistics), PREDICTION models
Abstract: Background The effects of thrombus imaging characteristics on procedural and clinical outcomes after ischemic stroke are increasingly being studied. These thrombus characteristics -- for eg, size, location, and density -- are commonly analyzed as separate entities. However, it is known that some of these thrombus characteristics are strongly related. Multicollinearity can lead to unreliable prediction models. We aimed to determine the distribution, correlation and clustering of thrombus imaging characteristics based on a large dataset of anterior-circulation acute ischemic stroke patients. Methods We measured thrombus imaging characteristics in the MR CLEAN Registry dataset, which included occlusion location, distance from the intracranial carotid artery to the thrombus (DT), thrombus length, density, perviousness, and clot burden score (CBS). We assessed intercorrelations with Spearman's coefficient (ρ) and grouped thrombi based on 1) occlusion location and 2) thrombus length, density and perviousness using unsupervised clustering. Results We included 934 patients, of which 22% had an internal carotid artery (ICA) occlusion, 61% M1, 16% M2, and 1% another occlusion location. All thrombus characteristics were significantly correlated. Higher CBS was strongly correlated with longer DT (ρ=0.67, p<0.01), and moderately correlated with shorter thrombus length (ρ=-0.41, p<0.01). In more proximal occlusion locations, thrombi were significantly longer, denser, and less pervious. Unsupervised clustering analysis resulted in four thrombus groups; however, the cohesion within and distinction between the groups were weak. Conclusions Thrombus imaging characteristics are significantly intercorrelated -- strong correlations should be considered in future predictive modeling studies. Clustering analysis showed there are no distinct thrombus archetypes -- novel treatments should consider this thrombus variability. [ABSTRACT FROM AUTHOR]
Published: 2023
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22. Determinants of Symptomatic Intracranial Hemorrhage After Endovascular Stroke Treatment: A Retrospective Cohort Study

Author: van der Steen, Wouter, primary, van der Ende, Nadinda A.M., additional, van Kranendonk, Katinka R., additional, Chalos, Vicky, additional, van Oostenbrugge, Robert J., additional, van Zwam, Wim H., additional, Roos, Yvo B.W.E.M., additional, van Doormaal, Pieter J., additional, van Es, Adriaan C.G.M., additional, Lingsma, Hester F., additional, Majoie, Charles B.L.M., additional, van der Lugt, Aad, additional, Dippel, Diederik W.J., additional, Roozenbeek, Bob, additional, Boiten, Jelis, additional, Albert Vos, Jan, additional, Jansen, Ivo G.H., additional, Mulder, Maxim J.H.L., additional, Goldhoorn, Robert- Jan B., additional, Compagne, Kars C.J., additional, Kappelhof, Manon, additional, Brouwer, Josje, additional, den Hartog, Sanne J., additional, Emmer, Bart J., additional, Coutinho, Jonathan M., additional, Schonewille, Wouter J., additional, Wermer, Marieke J.H., additional, van Walderveen, Marianne A.A., additional, Staals, Julie, additional, Hofmeijer, Jeannette, additional, Martens, Jasper M., additional, Lycklama à Nijeholt, Geert J., additional, de Bruijn, Sebastiaan F., additional, van Dijk, Lukas C., additional, van der Worp, H. Bart, additional, Lo, Rob H., additional, van Dijk, Ewoud J., additional, Boogaarts, Hieronymus D., additional, de Vries, J., additional, de Kort, Paul L.M., additional, van Tuijl, Julia, additional, Peluso, Jo P., additional, Fransen, Puck, additional, van den Berg, Jan S.P., additional, van Hasselt, Boudewijn A.A.M., additional, Aerden, Leo A.M., additional, Dallinga, René J., additional, Uyttenboogaart, Maarten, additional, Eschgi, Omid, additional, Bokkers, Reinoud P.H., additional, Schreuder, Tobien H.C.M.L., additional, Heijboer, Roel J.J., additional, Keizer, Koos, additional, Yo, Lonneke S.F., additional, den Hertog, Heleen M., additional, Bulut, Tomas, additional, Brouwers, Paul J.A.M., additional, Lycklama, Geert J., additional, Sprengers, Marieke E.S., additional, Jenniskens, Sjoerd F.M., additional, van den Berg, René, additional, Yoo, Albert J., additional, Beenen, Ludo F.M., additional, Postma, Alida A., additional, Roosendaal, Stefan D., additional, van der Kallen, Bas F.W., additional, van den Wijngaard, Ido R., additional, Vos, Jan Albert, additional, Bot, Joost, additional, Meijer, Anton, additional, Ghariq, Elyas, additional, van Proosdij, Marc P., additional, Krietemeijer, G. Menno, additional, Lo, Rob, additional, Dinkelaar, Wouter, additional, Auke, P.A., additional, Hammer, Bas, additional, Pegge, Sjoert, additional, van der Hoorn, Anouk, additional, Vinke, Saman, additional, Flach, H. Zwenneke, additional, el Ghannouti, Naziha, additional, Sterrenberg, Martin, additional, Pellikaan, Wilma, additional, Sprengers, Rita, additional, Elfrink, Marjan, additional, Simons, Michelle, additional, Vossers, Marjolein, additional, de Meris, Joke, additional, Vermeulen, Tamara, additional, Geerlings, Annet, additional, van Vemde, Gina, additional, Simons, Tiny, additional, Messchendorp, Gert, additional, Nicolaij, Nynke, additional, Bongenaar, Hester, additional, Bodde, Karin, additional, Kleijn, Sandra, additional, Lodico, Jasmijn, additional, Droste, Hanneke, additional, Wollaert, Maureen, additional, Verheesen, Sabrina, additional, Jeurrissen, D., additional, Bos, Erna, additional, Drabbe, Yvonne, additional, Sandiman, Michelle, additional, Aaldering, Nicoline, additional, Zweedijk, Berber, additional, Vervoort, Jocova, additional, Ponjee, Eva, additional, Romviel, Sharon, additional, Kanselaar, Karin, additional, Barning, Denn, additional, Venema, Esmee, additional, Geuskens, Ralph R., additional, van Straaten, Tim, additional, Ergezen, Saliha, additional, Harmsma, Roger R.M., additional, Muijres, Daan, additional, de Jong, Anouk, additional, Berkhemer, Olvert A., additional, Boers, Anna M.M., additional, Huguet, J., additional, Groot, P.F.C., additional, Mens, Marieke A., additional, Treurniet, Kilian M., additional, Tolhuisen, Manon L., additional, Alves, Heitor, additional, Weterings, Annick J., additional, Kirkels, Eleonora L.F., additional, Voogd, Eva J.H.F., additional, Schupp, Lieve M., additional, Collette, Sabine L., additional, Groot, Adrien E.D., additional, LeCouffe, Natalie E., additional, Konduri, Praneeta R., additional, Prasetya, Haryadi, additional, Arrarte- Terreros, Nerea, additional, Ramos, Lucas A., additional, Brown, Martin M., additional, Liebig, Thomas, additional, van der Heijden, Esther, additional, Ghannouti, Naziha, additional, Fleitour, Nadine, additional, Hooijenga, Imke, additional, Puppels, Corina, additional, Geerling, Annet, additional, Lindl-Velema, Annemieke, additional, de Ridder, Ans, additional, Greebe, Paut, additional, de Bont- Stikkelbroeck, Jose, additional, Haaglanden, MC, additional, Janssen, Kirsten, additional, Licher, Silvan, additional, Boodt, Nikki, additional, Ros, Adriaan, additional, Slokkers, Ilse, additional, Ganpat, Raymie-Jayce, additional, Mulder, Maxim, additional, Saiedie, Nawid, additional, Heshmatollah, Alis, additional, Schipperen, Stefanie, additional, Vinken, Stefan, additional, van Boxtel, Tiemen, additional, Koets, Jeroen, additional, Boers, Merel, additional, Santos, Emilie, additional, Borst, Jordi, additional, Jansen, Ivo, additional, Lucas, Marit, additional, Geuskens, Ralph Renan, additional, and Sales Barros, Roeland, additional
Published: 2022
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23. Timing of symptomatic intracranial hemorrhage after endovascular stroke treatment

Author: van der Steen, Wouter, primary, van der Ende, Nadinda AM, additional, van Kranendonk, Katinka R, additional, Chalos, Vicky, additional, Brouwer, Josje, additional, van Oostenbrugge, Robert J, additional, van Zwam, Wim H, additional, van Doormaal, Pieter J, additional, van Es, Adriaan CGM, additional, Majoie, Charles BLM, additional, van der Lugt, Aad, additional, Dippel, Diederik WJ, additional, and Roozenbeek, Bob, additional
Published: 2022
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24. Etiology of Large Vessel Occlusion Posterior Circulation Stroke: Results of the MR CLEAN Registry

Author: Pirson, F.A.V. (Anne), primary, Boodt, Nikki, additional, Brouwer, Josje, additional, Bruggeman, Agnetha A.E., additional, Hinsenveld, Wouter H., additional, Staals, Julie, additional, van Zwam, Wim H., additional, van der Leij, Christiaan, additional, Brans, Rutger J.B., additional, Majoie, Charles B.L.M., additional, Dippel, Diederik W.J., additional, van der Lugt, Aad, additional, Schonewille, Wouter J., additional, van Oostenbrugge, Robert J., additional, Roos, Yvo B.W.E.M., additional, Boiten, Jelis, additional, Albert Vos, Jan, additional, Jansen, Ivo G.H., additional, Mulder, Maxim J.H.L., additional, Goldhoorn, Robert- Jan B., additional, Compagne, Kars C.J., additional, Kappelhof, Manon, additional, den Hartog, Sanne J., additional, Roozenbeek, Bob, additional, Emmer, Bart J., additional, Coutinho, Jonathan M., additional, Vos, Jan Albert, additional, Wermer, Marieke J.H., additional, van Walderveen, Marianne A.A., additional, van Es, Adriaan C.G.M., additional, Hofmeijer, Jeannette, additional, Martens, Jasper M., additional, Lycklama à Nijeholt, Geert J., additional, de Bruijn, Sebastiaan F., additional, van Dijk, Lukas C., additional, Bart van der Worp, H., additional, Lo, Rob H., additional, van Dijk, Ewoud J., additional, Boogaarts, Hieronymus D., additional, de Vries, J., additional, de Kort, Paul L.M., additional, van Tuijl, Julia, additional, Peluso, Jo P., additional, Fransen, Puck, additional, van den Berg, Jan S.P., additional, van Hasselt, Boudewijn A.A.M., additional, Aerden, Leo A.M., additional, Dallinga, René J., additional, Uyttenboogaart, Maarten, additional, Eschgi, Omid, additional, Bokkers, Reinoud P.H., additional, Schreuder, Tobien H.C.M.L., additional, Heijboer, Roel J.J., additional, Keizer, Koos, additional, Yo, Lonneke S.F., additional, den Hertog, Heleen M., additional, Sturm, Emiel J.C., additional, Brouwers, Paul J.A.M., additional, Sprengers, Marieke E.S., additional, Jenniskens, Sjoerd F.M., additional, van den Berg, René, additional, Yoo, Albert J., additional, Beenen, Ludo F.M., additional, Postma, Alida A., additional, Roosendaal, Stefan D., additional, van der Kallen, Bas F.W., additional, van den Wijngaard, Ido R., additional, Bot, Joost, additional, van Doormaal, Pieter-Jan, additional, Meijer, Anton, additional, Ghariq, Elyas, additional, van Proosdij, Marc P., additional, Menno Krietemeijer, G., additional, Lo, Rob, additional, Gerrits, Dick, additional, Dinkelaar, Wouter, additional, Appelman, Auke P.A., additional, Hammer, Bas, additional, Pegge, Sjoert, additional, van der Hoorn, Anouk, additional, Vinke, Saman, additional, Cornelissen, Sandra, additional, Brans, Rutger, additional, Zwenneke Flach, H., additional, Lingsma, Hester F., additional, Ghannouti, Naziha el, additional, Sterrenberg, Martin, additional, Pellikaan, Wilma, additional, Sprengers, Rita, additional, Elfrink, Marjan, additional, Simons, Michelle, additional, Vossers, Marjolein, additional, de Meris, Joke, additional, Vermeulen, Tamara, additional, Geerlings, Annet, additional, van Vemde, Gina, additional, Simons, Tiny, additional, Messchendorp, Gert, additional, Nicolaij, Nynke, additional, Bongenaar, Hester, additional, Bodde, Karin, additional, Kleijn, Sandra, additional, Lodico, Jasmijn, additional, Droste, Hanneke, additional, Wollaert, Maureen, additional, Verheesen, Sabrina, additional, Jeurrissen, D., additional, Bos, Erna, additional, Drabbe, Yvonne, additional, Sandiman, Michelle, additional, Aaldering, Nicoline, additional, Zweedijk, Berber, additional, Vervoort, Jocova, additional, Ponjee, Eva, additional, Romviel, Sharon, additional, Kanselaar, Karin, additional, Barning, Denn, additional, Venema, Esmee, additional, Chalos, Vicky, additional, Geuskens, Ralph R., additional, van Straaten, Tim, additional, Ergezen, Saliha, additional, Harmsma, Roger R.M., additional, Muijres, Daan, additional, de Jong, Anouk, additional, Berkhemer, Olvert A., additional, Boers, Anna M.M., additional, Huguet, J., additional, Groot, P.F.C., additional, Mens, Marieke A., additional, van Kranendonk, Katinka R., additional, Treurniet, Kilian M., additional, Tolhuisen, Manon L., additional, Alves, Heitor, additional, Weterings, Annick J., additional, Kirkels, Eleonora L.F., additional, Voogd, Eva J.H.F., additional, Schupp, Lieve M., additional, Collette, Sabine L., additional, Groot, Adrien E.D., additional, LeCouffe, Natalie E., additional, Konduri, Praneeta R., additional, Prasetya, Haryadi, additional, Arrarte-Terreros, Nerea, additional, Ramos, Lucas A., additional, and Pirson, Anne F.A.V., additional
Published: 2022
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25. Thrombus radiomics in patients with anterior circulation acute ischemic stroke undergoing endovascular treatment

Author: van Voorst, Henk, primary, Bruggeman, Agnetha A E, additional, Yang, Wenjin, additional, Andriessen, Jurr, additional, Welberg, Elise, additional, Dutra, Bruna G, additional, Konduri, Praneeta R, additional, Arrarte Terreros, Nerea, additional, Hoving, Jan W, additional, Tolhuisen, Manon L, additional, Kappelhof, Manon, additional, Brouwer, Josje, additional, Boodt, Nikki, additional, van Kranendonk, Katinka R, additional, Koopman, Miou S, additional, Hund, Hajo M, additional, Krietemeijer, Menno, additional, van Zwam, Wim H, additional, van Beusekom, Heleen M M, additional, van der Lugt, Aad, additional, Emmer, Bart J, additional, Marquering, Henk A, additional, Roos, Yvo B W E M, additional, Caan, Matthan W A, additional, and Majoie, Charles B L M, additional
Published: 2022
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26. Thrombus imaging characteristics within acute ischemic stroke: similarities and interdependence

Author: Arrarte Terreros, Nerea, primary, Bruggeman, Agnetha AE, additional, Kappelhof, Manon, additional, Tolhuisen, Manon L, additional, Brouwer, Josje, additional, Hoving, Jan W, additional, Konduri, Praneeta R, additional, van Kranendonk, Katinka R, additional, Dutra, Bruna G, additional, Alves, Heitor CBR, additional, Dippel, Diederik WJ, additional, van Zwam, Wim H, additional, Beenen, Ludo FM, additional, Yo, Lonneke SF, additional, van Bavel, Ed, additional, Majoie, Charles BLM, additional, and Marquering, Henk A, additional
Published: 2022
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27. Estimation of treatment effects in observational stroke care data: comparison of statistical approaches

Author: Amini, Marzyeh, van Leeuwen, Nikki, Eijkenaar, Frank, van de Graaf, Rob, Samuels, Noor, van Doormaal, Pieter Jan, Roozenbeek, Bob, Dippel, Diederik W.J., Lingsma, Hester F., van der Lugt, Aad, Vos, Jan Albert, Brouwer, Josje, den Hartog, Sanne J., Hinsenveld, Wouter H., Kappelhof, Manon, Compagne, Kars C.J., Goldhoorn, Robert Jan B., Mulder, Maxim J.H.L., Jansen, Ivo G.H., Emmer, Bart J., de Bruijn, Sebastiaan F., de Vries, J., Fransen, Puck, den Hertog, Heleen M., Brouwers, Paul, Jenniskens, Sjoerd F.M., Roosendaal, Stefan D., Ghariq, Elyas, Dinkelaar, Wouter, el Ghannouti, Naziha, Sterrenberg, Martin, Sprengers, Rita, Verheesen, Sabrina, Khalilzada, Mostafa, Venema, Esmee, Chalos, Vicky, Ergezen, Saliha, Harmsma, Roger R.M., Muijres, Daan, de Jong, Anouk, Berkhemer, Olvert A., Treurniet, Kilian M., LeCouffe, Natalie E., Radiology and nuclear medicine, ACS - Atherosclerosis & ischemic syndromes, Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Damage and Repair in Cancer Development and Cancer Treatment (DARE), MUMC+: MA Neurologie (3), Klinische Neurowetenschappen, MUMC+: Hersen en Zenuw Centrum (3), RS: Carim - B05 Cerebral small vessel disease, Clinical Neurophysiology, TechMed Centre, Public Health, Health Systems and Insurance (HSI), Radiology & Nuclear Medicine, Neurology, Neurosciences, Erasmus School of Law, General Practice, Emergency Medicine, Intensive Care, Erasmus MC other, Medical Oncology, Amsterdam Neuroscience - Neurovascular Disorders, Radiology and Nuclear Medicine, and ACS - Microcirculation
Subjects: Epidemiology, Acute ischemic stroke, General anesthesia, Health Informatics, ADJUSTMENT, Intravenous thrombolysis, GENERAL-ANESTHESIA, Fibrinolytic Agents, CONSCIOUS SEDATION, Humans, Thrombolytic Therapy, ACUTE ISCHEMIC-STROKE, Unmeasured confounding, OUTCOMES, Confounding by indication, BINARY DATA, Fibrinolytic Agents/therapeutic use, Endovascular Procedures, Other Research Radboud Institute for Health Sciences [Radboudumc 0], THROMBECTOMY, INSTRUMENTAL VARIABLE METHODS, Stroke, Endovascular Procedures/methods, PROPENSITY SCORE, Instrumental variable, Treatment Outcome, ENDOVASCULAR TREATMENT, Statistical approaches, Ecological-analysis, Stroke/drug therapy
Abstract: Introduction Various statistical approaches can be used to deal with unmeasured confounding when estimating treatment effects in observational studies, each with its own pros and cons. This study aimed to compare treatment effects as estimated by different statistical approaches for two interventions in observational stroke care data. Patients and methods We used prospectively collected data from the MR CLEAN registry including all patients (n = 3279) with ischemic stroke who underwent endovascular treatment (EVT) from 2014 to 2017 in 17 Dutch hospitals. Treatment effects of two interventions – i.e., receiving an intravenous thrombolytic (IVT) and undergoing general anesthesia (GA) before EVT – on good functional outcome (modified Rankin Scale ≤2) were estimated. We used three statistical regression-based approaches that vary in assumptions regarding the source of unmeasured confounding: individual-level (two subtypes), ecological, and instrumental variable analyses. In the latter, the preference for using the interventions in each hospital was used as an instrument. Results Use of IVT (range 66–87%) and GA (range 0–93%) varied substantially between hospitals. For IVT, the individual-level (OR ~ 1.33) resulted in significant positive effect estimates whereas in instrumental variable analysis no significant treatment effect was found (OR 1.11; 95% CI 0.58–1.56). The ecological analysis indicated no statistically significant different likelihood (β = − 0.002%; P = 0.99) of good functional outcome at hospitals using IVT 1% more frequently. For GA, we found non-significant opposite directions of points estimates the treatment effect in the individual-level (ORs ~ 0.60) versus the instrumental variable approach (OR = 1.04). The ecological analysis also resulted in a non-significant negative association (0.03% lower probability). Discussion and conclusion Both magnitude and direction of the estimated treatment effects for both interventions depend strongly on the statistical approach and thus on the source of (unmeasured) confounding. These issues should be understood concerning the specific characteristics of data, before applying an approach and interpreting the results. Instrumental variable analysis might be considered when unobserved confounding and practice variation is expected in observational multicenter studies.
Published: 2022
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28. Endovascular Thrombectomy in Young Patients With Stroke: A MR CLEAN Registry Study

Author: Brouwer, Josje, Smaal, Johanna A., Emmer, Bart J., Ridder, Inger R. de, Wijngaard, Ido R. van den, Leeuw, F.E. de, Oostenbrugge, Robert J. van, Coutinho, Jonathan M., Brouwer, Josje, Smaal, Johanna A., Emmer, Bart J., Ridder, Inger R. de, Wijngaard, Ido R. van den, Leeuw, F.E. de, Oostenbrugge, Robert J. van, and Coutinho, Jonathan M.
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Published: 2022

29. Etiology of Large Vessel Occlusion Posterior Circulation Stroke: Results of the MR CLEAN Registry

Author: Pirson, F. A. V. Anne, Boodt, Nikki, Brouwer, Josje, Bruggeman, Agnetha A. E., Hinsenveld, Wouter H., Staals, Julie, van Zwam, Wim H., van der Leij, Christiaan, Brans, Rutger J. B., Majoie, Charles B. L. M., Dippel, Diederik W. J., van der Lugt, Aad, Schonewille, Wouter J., van Oostenbrugge, Robert J., Pirson, F. A. V. Anne, Boodt, Nikki, Brouwer, Josje, Bruggeman, Agnetha A. E., Hinsenveld, Wouter H., Staals, Julie, van Zwam, Wim H., van der Leij, Christiaan, Brans, Rutger J. B., Majoie, Charles B. L. M., Dippel, Diederik W. J., van der Lugt, Aad, Schonewille, Wouter J., and van Oostenbrugge, Robert J.
Abstract: BACKGROUND: In patients with large vessel occlusion stroke of the anterior circulation, underlying cause is a determinant of outcome. Whether this is the case for posterior circulation large vessel occlusion stroke has yet to be determined. We aimed to report on cause in patients with posterior circulation stroke treated with endovascular thrombectomy and to analyze the association with functional outcome. METHODS: We used data of patients with posterior circulation stroke included in the MR CLEAN (Multicenter Randomized Controlled Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands) registry, a prospective multicenter observational study, between 2014 and 2018. Stroke cause was categorized into large artery atherosclerosis (LAA), cardioembolism, arterial dissection, embolic stroke of undetermined source (ESUS), other determined cause, or undetermined cause. For primary analysis on the association between cause and outcome, we used multivariable ordinal logistic regression analysis to estimate the adjusted common odds ratio for a shift towards a better functional outcome on the modified Rankin Scale at 90 days with LAA as a reference group. Secondary outcomes included favorable functional outcome (modified Rankin Scale score 0–3), National Institutes of Health Stroke Scale score at 24 to 48 hours, reperfusion on digital subtraction angiography, and stroke progression. RESULTS: Of 264 patients with posterior circulation stroke, 84 (32%) had LAA, 48 (18%) cardioembolism, 31 (12%) dissection, and 14 (5%) ESUS. Patients with a dissection were younger (48 [interquartile range, 43–60] years) and had a lower National Institutes of Health Stroke Scale at baseline (12 [interquartile range, 6–31]) than patients with other cause. Functional outcome was better for patients with cardioembolism and ESUS compared to LAA (modified Rankin Scale adjusted common odds ratio, 2.4 [95% CI, 1.1–5.
Published: 2022

30. Etiology of Large Vessel Occlusion Posterior Circulation Stroke: Results of the MR CLEAN Registry

Author: Pirson, F A V Anne, Boodt, Nikki, Brouwer, Josje, Bruggeman, Agnetha A E, Hinsenveld, Wouter H, Staals, Julie, van Zwam, Wim H, van der Leij, Christiaan, Brans, Rutger J B, Majoie, Charles B L M, Dippel, Diederik W J, van der Lugt, Aad, Schonewille, Wouter J, van Oostenbrugge, Robert J, MR CLEAN Registry Investigators, Pirson, F A V Anne, Boodt, Nikki, Brouwer, Josje, Bruggeman, Agnetha A E, Hinsenveld, Wouter H, Staals, Julie, van Zwam, Wim H, van der Leij, Christiaan, Brans, Rutger J B, Majoie, Charles B L M, Dippel, Diederik W J, van der Lugt, Aad, Schonewille, Wouter J, van Oostenbrugge, Robert J, and MR CLEAN Registry Investigators
Abstract: BACKGROUND: In patients with large vessel occlusion stroke of the anterior circulation, underlying cause is a determinant of outcome. Whether this is the case for posterior circulation large vessel occlusion stroke has yet to be determined. We aimed to report on cause in patients with posterior circulation stroke treated with endovascular thrombectomy and to analyze the association with functional outcome.METHODS: We used data of patients with posterior circulation stroke included in the MR CLEAN (Multicenter Randomized Controlled Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands) registry, a prospective multicenter observational study, between 2014 and 2018. Stroke cause was categorized into large artery atherosclerosis (LAA), cardioembolism, arterial dissection, embolic stroke of undetermined source (ESUS), other determined cause, or undetermined cause. For primary analysis on the association between cause and outcome, we used multivariable ordinal logistic regression analysis to estimate the adjusted common odds ratio for a shift towards a better functional outcome on the modified Rankin Scale at 90 days with LAA as a reference group. Secondary outcomes included favorable functional outcome (modified Rankin Scale score 0-3), National Institutes of Health Stroke Scale score at 24 to 48 hours, reperfusion on digital subtraction angiography, and stroke progression.RESULTS: Of 264 patients with posterior circulation stroke, 84 (32%) had LAA, 48 (18%) cardioembolism, 31 (12%) dissection, and 14 (5%) ESUS. Patients with a dissection were younger (48 [interquartile range, 43-60] years) and had a lower National Institutes of Health Stroke Scale at baseline (12 [interquartile range, 6-31]) than patients with other cause. Functional outcome was better for patients with cardioembolism and ESUS compared to LAA (modified Rankin Scale adjusted common odds ratio, 2.4 [95% CI, 1.1-5.2], respectively adjusted common odds ratio, 3.1 [95%
Published: 2022

31. Endovascular Treatment for Posterior Circulation Stroke in Routine Clinical Practice: Results of the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands Registry

Author: Pirson, F Anne V, Boodt, Nikki, Brouwer, Josje, Bruggeman, Agnetha A E, den Hartog, Sanne J, Goldhoorn, Robert-Jan B, Langezaal, Lucianne C M, Staals, Julie, van Zwam, Wim H, van der Leij, Christiaan, Brans, Rutger J B, Majoie, Charles B L M, Coutinho, Jonathan M, Emmer, Bart J, Dippel, Diederik W J, van der Lugt, Aad, Vos, Jan-Albert, van Oostenbrugge, Robert J, Schonewille, Wouter J, MR CLEAN Registry Investigators, Pirson, F Anne V, Boodt, Nikki, Brouwer, Josje, Bruggeman, Agnetha A E, den Hartog, Sanne J, Goldhoorn, Robert-Jan B, Langezaal, Lucianne C M, Staals, Julie, van Zwam, Wim H, van der Leij, Christiaan, Brans, Rutger J B, Majoie, Charles B L M, Coutinho, Jonathan M, Emmer, Bart J, Dippel, Diederik W J, van der Lugt, Aad, Vos, Jan-Albert, van Oostenbrugge, Robert J, Schonewille, Wouter J, and MR CLEAN Registry Investigators
Abstract: BACKGROUND AND PURPOSE: The benefit of endovascular treatment (EVT) for posterior circulation stroke (PCS) remains uncertain, and little is known on treatment outcomes in clinical practice. This study evaluates outcomes of a large PCS cohort treated with EVT in clinical practice. Simultaneous to this observational study, several intervention centers participated in the BASICS trial (Basilar Artery International Cooperation Study), which tested the efficacy of EVT for basilar artery occlusion in a randomized setting. We additionally compared characteristics and outcomes of patients treated outside BASICS in trial centers to those from nontrial centers.METHODS: We included patients with PCS from the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands Registry: a prospective, multicenter, observational study of patients who underwent EVT in the Netherlands between 2014 and 2018. Primary outcome was a score of 0 to 3 on the modified Rankin Scale at 90 days. Secondary outcomes included reperfusion status and symptomatic intracranial hemorrhage. For outcome comparison between patients treated in trial versus nontrial centers, we used ordinal logistic regression analysis.RESULTS: We included 264 patients of whom 135 (51%) had received intravenous thrombolysis. The basilar artery was most often involved (77%). Favorable outcome (modified Rankin Scale score 0-3) was observed in 115/252 (46%) patients, and 109/252 (43%) patients died. Successful reperfusion was achieved in 178/238 (75%), and symptomatic intracranial hemorrhage occurred in 9/264 (3%). The 154 nontrial patients receiving EVT in BASICS trial centers had similar characteristics and outcomes as the 110 patients treated in nontrial centers (modified Rankin Scale adjusted cOR: 0.77 [95% CI, 0.5-1.2]).CONCLUSIONS: Our study shows that high rates of favorable clinical outcome and successful reperfusion can be achieved with EVT for PCS, de
Published: 2022

32. Aspiration Versus Stent Retriever Thrombectomy for Posterior Circulation Stroke

Author: Bernsen, Marie Louise E, Bruggeman, Agnetha A E, Brouwer, Josje, Emmer, Bart J, Majoie, Charles B L M, Coutinho, Jonathan M, Goldhoorn, Robert-Jan B, van Oostenbrugge, Robert J, van Zwam, Wim H, van der Leij, Christiaan, Schonewille, Wouter J, Martens, Jasper M, Hofmeijer, Jeannette, MR CLEAN Registry Investigators, Bernsen, Marie Louise E, Bruggeman, Agnetha A E, Brouwer, Josje, Emmer, Bart J, Majoie, Charles B L M, Coutinho, Jonathan M, Goldhoorn, Robert-Jan B, van Oostenbrugge, Robert J, van Zwam, Wim H, van der Leij, Christiaan, Schonewille, Wouter J, Martens, Jasper M, Hofmeijer, Jeannette, and MR CLEAN Registry Investigators
Abstract: Background and Purpose: Whereas a clear benefit of endovascular treatment for anterior circulation stroke has been established, randomized trials assessing the posterior circulation have failed to show efficacy. Previous studies in anterior circulation stroke suggest that advanced thrombectomy devices were of great importance in achieving clinical benefit. Little is known about the effect of thrombectomy techniques on outcomes in posterior circulation stroke. In this study, we compare first-line strategy of direct aspiration to stent retriever thrombectomy for posterior circulation stroke. Methods: We analyzed data of patients with a posterior circulation stroke who were included in the Multicentre Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands Registry between March 2014 and December 2018, a prospective, nationwide study, in which data were collected from consecutive patients who underwent endovascular treatment for ischemic stroke in the Netherlands. We compared patients who underwent first-line aspiration versus stent retriever thrombectomy. Primary outcome was functional outcome according to the modified Rankin Scale. Secondary outcomes were reperfusion grade, complication rate, and procedure duration. Associations between thrombectomy technique and outcome measures were estimated with multivariable ordinal logistic regression analyses. Results: Overall, 71 of 205 patients (35%) were treated with aspiration, and 134 (65%) with stent retriever thrombectomy. Patients in the aspiration group had a lower pc-ASPECTS on baseline computed tomography, and general anesthesia was more often applied in this group. First-line aspiration was associated with better functional outcome compared with stent retriever thrombectomy (adjusted common odds ratio for a 1-point improvement on the modified Rankin Scale 1.94 [95% CI, 1.03-3.65]). Successful reperfusion (extended Thrombolysis in Cerebral Infarction ≥2B) was achieved more
Published: 2022

33. Improvements in Endovascular Treatment for Acute Ischemic Stroke:A Longitudinal Study in the MR CLEAN Registry

Author: Compagne, Kars C.J., Kappelhof, Manon, Hinsenveld, Wouter H., Brouwer, Josje, Goldhoorn, Robert Jan B., Uyttenboogaart, Maarten, Bokkers, Reinoud P.H., Schonewille, Wouter J., Martens, Jasper M., Hofmeijer, Jeannette, van der Worp, H. Bart, Lo, Rob T.H., Keizer, Koos, Yo, Lonneke S.F., Lycklama À Nijeholt, Geert J., den Hertog, Heleen M., Sturm, Emiel J.C., Brouwers, Paul J.A.M., van Walderveen, Marianne A.A., Wermer, Marieke J.H., de Bruijn, Sebastiaan F., van Dijk, Lukas C., Boogaarts, Hieronymus D., van Dijk, Ewout J., van Tuijl, Julia H., Peluso, Jo P.P., de Kort, Paul L.M., van Hasselt, Boudewijn A.A.M., Fransen, Puck S., Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Jenniskens, Sjoerd F.M., Sprengers, Marieke E.S., Ghariq, Elias, van den Wijngaard, Ido R., Roosendaal, Stefan D., Meijer, Anton F.J.A., Beenen, Ludo F.M., Postma, Alida A., van den Berg, René, Yoo, Albert J., van Doormaal, Pieter Jan, van Proosdij, Marc P., Krietemeijer, Menno G.M., Gerrits, Dick G., Vos, Jan Albert, Emmer, Bart J., Roozenbeek, Bob, Dippel, Diederik W.J., van der Lugt, Aad, Compagne, Kars C.J., Kappelhof, Manon, Hinsenveld, Wouter H., Brouwer, Josje, Goldhoorn, Robert Jan B., Uyttenboogaart, Maarten, Bokkers, Reinoud P.H., Schonewille, Wouter J., Martens, Jasper M., Hofmeijer, Jeannette, van der Worp, H. Bart, Lo, Rob T.H., Keizer, Koos, Yo, Lonneke S.F., Lycklama À Nijeholt, Geert J., den Hertog, Heleen M., Sturm, Emiel J.C., Brouwers, Paul J.A.M., van Walderveen, Marianne A.A., Wermer, Marieke J.H., de Bruijn, Sebastiaan F., van Dijk, Lukas C., Boogaarts, Hieronymus D., van Dijk, Ewout J., van Tuijl, Julia H., Peluso, Jo P.P., de Kort, Paul L.M., van Hasselt, Boudewijn A.A.M., Fransen, Puck S., Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Jenniskens, Sjoerd F.M., Sprengers, Marieke E.S., Ghariq, Elias, van den Wijngaard, Ido R., Roosendaal, Stefan D., Meijer, Anton F.J.A., Beenen, Ludo F.M., Postma, Alida A., van den Berg, René, Yoo, Albert J., van Doormaal, Pieter Jan, van Proosdij, Marc P., Krietemeijer, Menno G.M., Gerrits, Dick G., Vos, Jan Albert, Emmer, Bart J., Roozenbeek, Bob, Dippel, Diederik W.J., and van der Lugt, Aad
Abstract: BACKGROUND: We evaluated data from all patients in the Netherlands who underwent endovascular treatment for acute ischemic stroke in the past 3.5 years, to identify nationwide trends in time to treatment and procedural success, and assess their effect on clinical outcomes. METHODS: We included patients with proximal occlusions of the anterior circulation from the second and first cohorts of the MR CLEAN (Multicenter Randomized Clinical trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands) Registry (March 2014 to June 2016; June 2016 to November 2017, respectively). We compared workflow times and rates of successful reperfusion (defined as an extended Thrombolysis in Cerebral Infarction score of 2B-3) between cohorts and chronological quartiles (all included patients stratified in chronological quartiles of intervention dates to create equally sized groups over the study period). Multivariable ordinal logistic regression was used to assess differences in the primary outcome (ordinal modified Rankin Scale at 90 days). RESULTS: Baseline characteristics were similar between cohorts (second cohort n=1692, first cohort n=1488) except for higher age, poorer collaterals, and less signs of early ischemia on computed tomography in the second cohort. Time from stroke onset to groin puncture and reperfusion were shorter in the second cohort (median 185 versus 210 minutes; P<0.001 and 236 versus 270 minutes; P<0.001, respectively). Successful reperfusion was achieved more often in the second than in the first cohort (72% versus 66%; P<0.001). Functional outcome significantly improved (adjusted common odds ratio 1.23 [95% CI, 1.07-1.40]). This effect was attenuated by adjustment for time from onset to reperfusion (adjusted common odds ratio, 1.12 [95% CI, 0.98-1.28]) and successful reperfusion (adjusted common odds ratio, 1.13 [95% CI, 0.99-1.30]). Outcomes were consistent in the analysis per chronological quartile. CONCLUSIONS: Clinical outcom
Published: 2022

34. Deep-Learning-Based Thrombus Localization and Segmentation in Patients with Posterior Circulation Stroke

Author: Zoetmulder, Riaan, Bruggeman, Agnetha A.E., Išgum, Ivana, Gavves, Efstratios, Majoie, Charles B.L.M., Beenen, Ludo F.M., Dippel, Diederik W.J., Boodt, Nikkie, Den Hartog, Sanne J., Van Doormaal, Pieter J., Cornelissen, Sandra A.P., Roos, Yvo B.W.E.M., Brouwer, Josje, Schonewille, Wouter J., Pirson, Anne F.V., Van Zwam, Wim H., Leij, Christiaan Van Der, Brans, Rutger J.B., Adriaan, Adriaan C.G., Marquering, Henk A., Zoetmulder, Riaan, Bruggeman, Agnetha A.E., Išgum, Ivana, Gavves, Efstratios, Majoie, Charles B.L.M., Beenen, Ludo F.M., Dippel, Diederik W.J., Boodt, Nikkie, Den Hartog, Sanne J., Van Doormaal, Pieter J., Cornelissen, Sandra A.P., Roos, Yvo B.W.E.M., Brouwer, Josje, Schonewille, Wouter J., Pirson, Anne F.V., Van Zwam, Wim H., Leij, Christiaan Van Der, Brans, Rutger J.B., Adriaan, Adriaan C.G., and Marquering, Henk A.
Abstract: Thrombus volume in posterior circulation stroke (PCS) has been associated with outcome, through recanalization. Manual thrombus segmentation is impractical for large scale analysis of image characteristics. Hence, in this study we develop the first automatic method for thrombus localization and segmentation on CT in patients with PCS. In this multi-center retrospective study, 187 patients with PCS from the MR CLEAN Registry were included. We developed a convolutional neural network (CNN) that segments thrombi and restricts the volume-of-interest (VOI) to the brainstem (Polar-UNet). Furthermore, we reduced false positive localization by removing small-volume objects, referred to as volume-based removal (VBR). Polar-UNet is benchmarked against a CNN that does not restrict the VOI (BL-UNet). Performance metrics included the intra-class correlation coefficient (ICC) between automated and manually segmented thrombus volumes, the thrombus localization precision and recall, and the Dice coefficient. The majority of the thrombi were localized. Without VBR, Polar-UNet achieved a thrombus localization recall of 0.82, versus 0.78 achieved by BL-UNet. This high recall was accompanied by a low precision of 0.14 and 0.09. VBR improved precision to 0.65 and 0.56 for Polar-UNet and BL-UNet, respectively, with a small reduction in recall to 0.75 and 0.69. The Dice coefficient achieved by Polar-UNet was 0.44, versus 0.38 achieved by BL-UNet with VBR. Both methods achieved ICCs of 0.41 (95% CI: 0.27–0.54). Restricting the VOI to the brainstem improved the thrombus localization precision, recall, and segmentation overlap compared to the benchmark. VBR improved thrombus localization precision but lowered recall.
Published: 2022

35. Endovascular Treatment for Posterior Circulation Stroke in Routine Clinical Practice:Results of the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands Registry

Author: Pirson, F Anne V, Boodt, Nikki, Brouwer, Josje, Bruggeman, Agnetha A E, den Hartog, Sanne J, Goldhoorn, Robert-Jan B, Langezaal, Lucianne C M, Staals, Julie, van Zwam, Wim H, van der Leij, Christiaan, Brans, Rutger J B, Majoie, Charles B L M, Coutinho, Jonathan M, Emmer, Bart J, Dippel, Diederik W J, van der Lugt, Aad, Vos, Jan-Albert, van Oostenbrugge, Robert J, Schonewille, Wouter J, Pirson, F Anne V, Boodt, Nikki, Brouwer, Josje, Bruggeman, Agnetha A E, den Hartog, Sanne J, Goldhoorn, Robert-Jan B, Langezaal, Lucianne C M, Staals, Julie, van Zwam, Wim H, van der Leij, Christiaan, Brans, Rutger J B, Majoie, Charles B L M, Coutinho, Jonathan M, Emmer, Bart J, Dippel, Diederik W J, van der Lugt, Aad, Vos, Jan-Albert, van Oostenbrugge, Robert J, and Schonewille, Wouter J
Abstract: BACKGROUND AND PURPOSE: The benefit of endovascular treatment (EVT) for posterior circulation stroke (PCS) remains uncertain, and little is known on treatment outcomes in clinical practice. This study evaluates outcomes of a large PCS cohort treated with EVT in clinical practice. Simultaneous to this observational study, several intervention centers participated in the BASICS trial (Basilar Artery International Cooperation Study), which tested the efficacy of EVT for basilar artery occlusion in a randomized setting. We additionally compared characteristics and outcomes of patients treated outside BASICS in trial centers to those from nontrial centers.METHODS: We included patients with PCS from the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands Registry: a prospective, multicenter, observational study of patients who underwent EVT in the Netherlands between 2014 and 2018. Primary outcome was a score of 0 to 3 on the modified Rankin Scale at 90 days. Secondary outcomes included reperfusion status and symptomatic intracranial hemorrhage. For outcome comparison between patients treated in trial versus nontrial centers, we used ordinal logistic regression analysis.RESULTS: We included 264 patients of whom 135 (51%) had received intravenous thrombolysis. The basilar artery was most often involved (77%). Favorable outcome (modified Rankin Scale score 0-3) was observed in 115/252 (46%) patients, and 109/252 (43%) patients died. Successful reperfusion was achieved in 178/238 (75%), and symptomatic intracranial hemorrhage occurred in 9/264 (3%). The 154 nontrial patients receiving EVT in BASICS trial centers had similar characteristics and outcomes as the 110 patients treated in nontrial centers (modified Rankin Scale adjusted cOR: 0.77 [95% CI, 0.5-1.2]).CONCLUSIONS: Our study shows that high rates of favorable clinical outcome and successful reperfusion can be achieved with EVT for PCS, de
Published: 2022

36. Deep-Learning-Based Thrombus Localization and Segmentation in Patients with Posterior Circulation Stroke

Author: Zoetmulder, Riaan, primary, Bruggeman, Agnetha, additional, Išgum, Ivana, additional, Gavves, Efstratios, additional, Majoie, Charles, additional, Beenen, Ludo, additional, Dippel, Diederik, additional, Boodt, Nikkie, additional, den Hartog, Sanne, additional, van Doormaal, Pieter, additional, Cornelissen, Sandra, additional, Roos, Yvo, additional, Brouwer, Josje, additional, Schonewille, Wouter, additional, Pirson, Anne, additional, van Zwam, Wim, additional, van der Leij, Christiaan, additional, Brans, Rutger, additional, van Es, Adriaan, additional, and Marquering, Henk, additional
Published: 2022
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37. sj-docx-1-eso-10.1177_23969873221112279 – Supplemental material for Timing of symptomatic intracranial hemorrhage after endovascular stroke treatment

Author: van der Steen, Wouter, van der Ende, Nadinda AM, van Kranendonk, Katinka R, Chalos, Vicky, Brouwer, Josje, van Oostenbrugge, Robert J, van Zwam, Wim H, van Doormaal, Pieter J, van Es, Adriaan CGM, Majoie, Charles BLM, van der Lugt, Aad, Dippel, Diederik WJ, and Roozenbeek, Bob
Subjects: FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract: Supplemental material, sj-docx-1-eso-10.1177_23969873221112279 for Timing of symptomatic intracranial hemorrhage after endovascular stroke treatment by Wouter van der Steen, Nadinda AM van der Ende, Katinka R van Kranendonk, Vicky Chalos, Josje Brouwer, Robert J van Oostenbrugge, Wim H van Zwam, Pieter J van Doormaal, Adriaan CGM van Es, Charles BLM Majoie, Aad van der Lugt, Diederik WJ Dippel and Bob Roozenbeek in European Stroke Journal
Published: 2022
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38. Endovascular treatment for isolated posterior cerebral artery occlusion stroke in the MR CLEAN registry

Author: Brouwer, Josje, primary, Ergezen, Saliha, additional, Mulder, Maxim Johan Heymen Laurence, additional, Lycklama a Nijeholt, Geert J, additional, van Es, Adriaan C G M, additional, van der Lugt, Aad, additional, Dippel, Diederik W J, additional, Majoie, Charles B L M, additional, Roos, Yvo B W E M, additional, Coutinho, J M, additional, and Emmer, Bart J, additional
Published: 2022
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39. Fully Automated Thrombus Segmentation on CT Images of Patients with Acute Ischemic Stroke

Author: Mojtahedi, Mahsa, primary, Kappelhof, Manon, additional, Ponomareva, Elena, additional, Tolhuisen, Manon, additional, Jansen, Ivo, additional, Bruggeman, Agnetha A. E., additional, Dutra, Bruna G., additional, Yo, Lonneke, additional, LeCouffe, Natalie, additional, Hoving, Jan W., additional, van Voorst, Henk, additional, Brouwer, Josje, additional, Terreros, Nerea Arrarte, additional, Konduri, Praneeta, additional, Meijer, Frederick J. A., additional, Appelman, Auke, additional, Treurniet, Kilian M., additional, Coutinho, Jonathan M., additional, Roos, Yvo, additional, van Zwam, Wim, additional, Dippel, Diederik, additional, Gavves, Efstratios, additional, Emmer, Bart J., additional, Majoie, Charles, additional, and Marquering, Henk, additional
Published: 2022
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40. Abstract TP152: A Comparison Of Thrombus Characteristics In Patients With Anterior Circulation Stroke And Posterior Circulation Stroke In The Mr Clean Registry

Author: Bruggeman, Agnetha A, primary, Boodt, Nikki, additional, Kappelhof, Manon, additional, Hoving, Arnolt-Jan, additional, Brouwer, Josje, additional, Tolhuisen, Manon, additional, Arrarte Terreros, Nerea, additional, Konduri, Praneeta, additional, van Kranendonk, Katinka R, additional, Dippel, Diederik W, additional, van der Lugt, Aad, additional, van Zwam, Wim, additional, van der Leij, Christiaan, additional, van Es, Adriaan C, additional, Cornelissen, Sandra, additional, Brans, Rutger, additional, Marquering, Henk, additional, Majoie, Charles B, additional, and Emmer, Bart, additional
Published: 2022
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41. Hospital Variation in Time to Endovascular Treatment for Ischemic Stroke: What Is the Optimal Target for Improvement?

Author: den Hartog, Sanne J., primary, Lingsma, Hester F., additional, van Doormaal, Pieter‐Jan, additional, Hofmeijer, Jeannette, additional, Yo, Lonneke S. F., additional, Majoie, Charles B. L. M., additional, Dippel, Diederik W. J., additional, van der Lugt, Aad, additional, Roozenbeek, Bob, additional, Roos, Yvo B. W. E. M., additional, van Oostenbrugge, Robert J., additional, van Zwam, Wim H., additional, Boiten, Jelis, additional, Vos, Jan Albert, additional, Jansen, Ivo G. H., additional, Mulder, Maxim J. H. L., additional, Goldhoorn, Robert‐ Jan B., additional, Compagne, Kars C. J., additional, Kappelhof, Manon, additional, Brouwer, Josje, additional, den Hartog, Sanne J., additional, Hinsenveld, Wouter H., additional, van Es, Adriaan C. G. M., additional, Emmer, Bart J., additional, Coutinho, Jonathan M., additional, Schonewille, Wouter J., additional, Wermer, Marieke J. H., additional, van Walderveen, Marianne A. A., additional, Staals, Julie, additional, Martens, Jasper M., additional, Lycklama à Nijeholt, Geert J., additional, de Bruijn, Sebastiaan F., additional, van Dijk, Lukas C., additional, van der Worp, H. Bart, additional, Lo, Rob H., additional, van Dijk, Ewoud J., additional, Boogaarts, Hieronymus D., additional, de Vries, J., additional, de Kort, Paul L. M., additional, van Tuijl, Julia, additional, Peluso, Jo P., additional, Fransen, Puck, additional, van den Berg, Jan S. P., additional, van Hasselt, Boudewijn A. A. M., additional, Aerden, Leo A. M., additional, Dallinga, René J., additional, Uyttenboogaart, Maarten, additional, Eschgi, Omid, additional, Bokkers, Reinoud P. H., additional, Schreuder, Tobien H. C. M. L., additional, Heijboer, Roel J. J., additional, Keizer, Koos, additional, den Hertog, Heleen M., additional, Sturm, Emiel J. C., additional, Brouwers, Paul J. A. M., additional, Sprengers, Marieke E. S., additional, Jenniskens, Sjoerd F. M., additional, van den Berg, René, additional, Yoo, Albert J., additional, Beenen, Ludo F. M., additional, Postma, Alida A., additional, Roosendaal, Stefan D., additional, van der Kallen, Bas F. W., additional, van den Wijngaard, Ido R., additional, Bot, Joost, additional, Meijer, Anton, additional, Ghariq, Elyas, additional, van Proosdij, Marc P., additional, Menno Krietemeijer, G., additional, Gerrits, Dick, additional, Dinkelaar, Wouter, additional, Appelman, Auke P. A., additional, Hammer, Bas, additional, Pegge, Sjoert, additional, van der Hoorn, Anouk, additional, Vinke, Saman, additional, Zwenneke Flach, H, additional, Ghannouti, Naziha el, additional, Sterrenberg, Martin, additional, Pellikaan, Wilma, additional, Sprengers, Rita, additional, Elfrink, Marjan, additional, Simons, Michelle, additional, Vossers, Marjolein, additional, de Meris, Joke, additional, Vermeulen, Tamara, additional, Geerlings, Annet, additional, van Vemde, Gina, additional, Simons, Tiny, additional, Messchendorp, Gert, additional, Nicolaij, Nynke, additional, Bongenaar, Hester, additional, Bodde, Karin, additional, Kleijn, Sandra, additional, Lodico, Jasmijn, additional, Droste, Hanneke, additional, Wollaert, Maureen, additional, Verheesen, Sabrina, additional, Jeurrissen, D., additional, Bos, Erna, additional, Drabbe, Yvonne, additional, Sandiman, Michelle, additional, Aaldering, Nicoline, additional, Zweedijk, Berber, additional, Vervoort, Jocova, additional, Ponjee, Eva, additional, Romviel, Sharon, additional, Kanselaar, Karin, additional, Barning, Denn, additional, Venema, Esmee, additional, Chalos, Vicky, additional, Geuskens, Ralph R., additional, van Straaten, Tim, additional, Ergezen, Saliha, additional, Harmsma, Roger R. M., additional, Muijres, Daan, additional, de Jong, Anouk, additional, Berkhemer, Olvert A., additional, Boers, Anna M. M., additional, Huguet, J., additional, Groot, P. F. C., additional, Mens, Marieke A., additional, van Kranendonk, Katinka R., additional, Treurniet, Kilian M., additional, Tolhuisen, Manon L., additional, Alves, Heitor, additional, Weterings, Annick J., additional, Kirkels, Eleonora L. F., additional, Voogd, Eva J. H. F., additional, Schupp, Lieve M., additional, Collette, Sabine L., additional, Groot, Adrien E. D., additional, LeCouffe, Natalie E., additional, Konduri, Praneeta R., additional, Prasetya, Haryadi, additional, Arrarte‐Terreros, Nerea, additional, and Ramos, Lucas A., additional
Published: 2021
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42. Occult blood flow patterns distal to an occluded artery in acute ischemic stroke

Author: Arrarte Terreros, Nerea, primary, van Willigen, Bettine G, additional, Niekolaas, Wera S, additional, Tolhuisen, Manon L, additional, Brouwer, Josje, additional, Coutinho, Jonathan M, additional, Beenen, Ludo FM, additional, Majoie, Charles BLM, additional, van Bavel, Ed, additional, and Marquering, Henk A, additional
Published: 2021
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43. White Matter Lesions and Outcomes After Endovascular Treatment for Acute Ischemic Stroke: MR CLEAN Registry Results

Author: Uniken Venema, Simone M., primary, Postma, Alida A., additional, van den Wijngaard, Ido R., additional, Vos, Jan Albert, additional, Lingsma, Hester F., additional, Bokkers, Reinoud P.H., additional, Hofmeijer, Jeannette, additional, Dippel, Diederik W.J., additional, Majoie, Charles B., additional, van der Worp, H. Bart, additional, Lugt, Aad van der, additional, Roos, Yvo B.W.E.M., additional, van Oostenbrugge, Robert J., additional, van Zwam, Wim H., additional, Boiten, Jelis, additional, Jansen, Ivo G.H., additional, Mulder, Maxim J.H.L., additional, Goldhoorn, Robert- Jan B., additional, Compagne, Kars C.J., additional, Kappelhof, Manon, additional, Brouwer, Josje, additional, den Hartog, Sanne J., additional, Hinsenveld, Wouter H., additional, Roozenbeek, Bob, additional, van Es, Adriaan C.G.M., additional, Emmer, Bart J., additional, Coutinho, Jonathan M., additional, Schonewille, Wouter J., additional, Wermer, Marieke J.H., additional, van Walderveen, Marianne A.A., additional, Staals, Julie, additional, Martens, Jasper M., additional, Lycklama à Nijeholt, Geert J., additional, de Bruijn, Sebastiaan F., additional, van Dijk, Lukas C., additional, Lo, Rob H., additional, van Dijk, Ewoud J., additional, Boogaarts, Hieronymus D., additional, de Vries, J., additional, de Kort, Paul L.M., additional, van Tuijl, Julia, additional, Peluso, Jo P., additional, Fransen, Puck, additional, van den Berg, Jan S.P., additional, van Hasselt, Boudewijn A.A.M., additional, Aerden, Leo A.M., additional, Dallinga, René J., additional, Uyttenboogaart, Maarten, additional, Eschgi, Omid, additional, Schreuder, Tobien H.C.M.L., additional, Heijboer, Roel J.J., additional, Keizer, Koos, additional, Yo, Lonneke S.F., additional, den Hertog, Heleen M., additional, Sturm, Emiel J.C., additional, Brouwers, Paul J.A.M., additional, van der Lugt, Aad, additional, Sprengers, Marieke E.S., additional, Jenniskens, Sjoerd F.M., additional, van den Berg, René, additional, Yoo, Albert J., additional, Beenen, Ludo F.M., additional, Roosendaal, Stefan D., additional, van der Kallen, Bas F.W., additional, Bot, Joost, additional, van Doormaal, Pieter-Jan, additional, Meijer, Anton, additional, Ghariq, Elyas, additional, van Proosdij, Marc P., additional, Krietemeijer, G. Menno, additional, Lo, Rob, additional, Gerrits, Dick, additional, Dinkelaar, Wouter, additional, Appelman, Auke P.A., additional, Hammer, Bas, additional, Pegge, Sjoert, additional, van der Hoorn, Anouk, additional, Vinke, Saman, additional, Flach, H. Zwenneke, additional, el Ghannouti, Naziha, additional, Sterrenberg, Martin, additional, Pellikaan, Wilma, additional, Sprengers, Rita, additional, Elfrink, Marjan, additional, Simons, Michelle, additional, Vossers, Marjolein, additional, de Meris, Joke, additional, Vermeulen, Tamara, additional, Geerlings, Annet, additional, van Vemde, Gina, additional, Simons, Tiny, additional, Messchendorp, Gert, additional, Nicolaij, Nynke, additional, Bongenaar, Hester, additional, Bodde, Karin, additional, Kleijn, Sandra, additional, Lodico, Jasmijn, additional, Droste, Hanneke, additional, Wollaert, Maureen, additional, Verheesen, Sabrina, additional, Jeurrissen, D., additional, Bos, Erna, additional, Drabbe, Yvonne, additional, Sandiman, Michelle, additional, Aaldering, Nicoline, additional, Zweedijk, Berber, additional, Vervoort, Jocova, additional, Ponjee, Eva, additional, Romviel, Sharon, additional, Kanselaar, Karin, additional, Barning, Denn, additional, Venema, Esmee, additional, Chalos, Vicky, additional, Geuskens, Ralph R., additional, van Straaten, Tim, additional, Ergezen, Saliha, additional, Harmsma, Roger R.M., additional, Muijres, Daan, additional, de Jong, Anouk, additional, Berkhemer, Olvert A., additional, Boers, Anna M.M., additional, Huguet, J., additional, Groot, P.F.C., additional, Mens, Marieke A., additional, van Kranendonk, Katinka R., additional, Treurniet, Kilian M., additional, Tolhuisen, Manon L., additional, Alves, Heitor, additional, Weterings, Annick J., additional, Kirkels, Eleonora L.F., additional, Voogd, Eva J.H.F., additional, Schupp, Lieve M., additional, Collette, Sabine L., additional, Groot, Adrien E.D., additional, LeCouffe, Natalie E., additional, Konduri, Praneeta R., additional, Prasetya, Haryadi, additional, Arrarte-Terreros, Nerea, additional, and Ramos, Lucas A., additional
Published: 2021
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44. Effect of First‐Pass Reperfusion on Outcome After Endovascular Treatment for Ischemic Stroke

Author: den Hartog, Sanne J., primary, Zaidat, Osama, additional, Roozenbeek, Bob, additional, van Es, Adriaan C. G. M., additional, Bruggeman, Agnetha A. E., additional, Emmer, Bart J., additional, Majoie, Charles B. L. M., additional, van Zwam, Wim H., additional, van den Wijngaard, Ido R., additional, van Doormaal, Pieter Jan, additional, Lingsma, Hester F., additional, Burke, James F., additional, Dippel, Diederik W. J., additional, van der Lugt, Aad, additional, Roos, Yvo B. W. E. M., additional, van Oostenbrugge, Robert J., additional, Boiten, Jelis, additional, Vos, Jan Albert, additional, Jansen, Ivo G. H., additional, Mulder, Maxim J. H. L., additional, Goldhoorn, Robert‐Jan B., additional, Compagne, Kars C. J., additional, Kappelhof, Manon, additional, Brouwer, Josje, additional, Hinsenveld, Wouter H., additional, Coutinho, Jonathan M., additional, Schonewille, Wouter J., additional, Wermer, Marieke J. H., additional, van Walderveen, Marianne A. A., additional, Staals, Julie, additional, Hofmeijer, Jeannette, additional, Martens, Jasper M., additional, Lycklama à Nijeholt, Geert J., additional, de Bruijn, Sebastiaan F., additional, van Dijk, Lukas C., additional, van der Worp, H. Bart, additional, Lo, Rob H., additional, van Dijk, Ewoud J., additional, Boogaarts, Hieronymus D., additional, de Vries, J., additional, de Kort, Paul L. M., additional, van Tuijl, Julia, additional, Peluso, Jo P., additional, Fransen, Puck, additional, van den Berg, Jan S. P., additional, van Hasselt, Boudewijn A. A. M., additional, Aerden, Leo A. M., additional, Dallinga, René J., additional, Uyttenboogaart, Maarten, additional, Eschgi, Omid, additional, Bokkers, Reinoud P. H., additional, Schreuder, Tobien H. C. M. L., additional, Heijboer, Roel J. J., additional, Keizer, Koos, additional, Yo, Lonneke S. F., additional, den Hertog, Heleen M., additional, Sturm, Emiel J. C., additional, Brouwers, Paul J. A. M., additional, Sprengers, Marieke E. S., additional, Jenniskens, Sjoerd F. M., additional, van den Berg, René, additional, Yoo, Albert J., additional, Beenen, Ludo F. M., additional, Postma, Alida A., additional, Roosendaal, Stefan D., additional, van der Kallen, Bas F. W., additional, Bot, Joost, additional, Meijer, Anton, additional, Ghariq, Elyas, additional, van Proosdij, Marc P., additional, Krietemeijer, G. Menno, additional, Gerrits, Dick, additional, Dinkelaar, Wouter, additional, Appelman, Auke P. A., additional, Hammer, Bas, additional, Pegge, Sjoert, additional, van der Hoorn, Anouk, additional, Vinke, Saman, additional, Flach, H. Zwenneke, additional, el Ghannouti, Naziha, additional, Sterrenberg, Martin, additional, Pellikaan, Wilma, additional, Sprengers, Rita, additional, Elfrink, Marjan, additional, Simons, Michelle, additional, Vossers, Marjolein, additional, de Meris, Joke, additional, Vermeulen, Tamara, additional, Geerlings, Annet, additional, van Vemde, Gina, additional, Simons, Tiny, additional, Messchendorp, Gert, additional, Nicolaij, Nynke, additional, Bongenaar, Hester, additional, Bodde, Karin, additional, Kleijn, Sandra, additional, Lodico, Jasmijn, additional, Droste, Hanneke, additional, Wollaert, Maureen, additional, Verheesen, Sabrina, additional, Jeurrissen, D., additional, Bos, Erna, additional, Drabbe, Yvonne, additional, Sandiman, Michelle, additional, Aaldering, Nicoline, additional, Zweedijk, Berber, additional, Vervoort, Jocova, additional, Ponjee, Eva, additional, Romviel, Sharon, additional, Kanselaar, Karin, additional, Barning, Denn, additional, Venema, Esmee, additional, Chalos, Vicky, additional, Geuskens, Ralph R., additional, van Straaten, Tim, additional, Ergezen, Saliha, additional, Harmsma, Roger R. M., additional, Muijres, Daan, additional, de Jong, Anouk, additional, Berkhemer, Olvert A., additional, Boers, Anna M. M., additional, Huguet, J., additional, Groot, P. F. C., additional, Mens, Marieke A., additional, van Kranendonk, Katinka R., additional, Treurniet, Kilian M., additional, Tolhuisen, Manon L., additional, Alves, Heitor, additional, Weterings, Annick J., additional, Kirkels, Eleonora L. F., additional, Voogd, Eva J. H. F., additional, Schupp, Lieve M., additional, Collette, Sabine L., additional, Groot, Adrien E. D., additional, LeCouffe, Natalie E., additional, Konduri, Praneeta R., additional, Prasetya, Haryadi, additional, Arrarte‐Terreros, Nerea, additional, and Ramos, Lucas A., additional
Published: 2021
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45. Abstract P365: Effect of Radiological Thrombus Characteristics on Results of First-Line Endovascular Treatment Approach for Acute Ischemic Stroke

Author: Kappelhof, Manon, primary, Bruggeman, Agnetha, additional, Brouwer, Josje, additional, Arrarte Terreros, Nerea, additional, Konduri, Praneeta R, additional, Markenstein, Jeroen E, additional, van den Berg, René, additional, Sprengers, Marieke E, additional, van Zwam, Wim H, additional, van der Leij, Christiaan, additional, van den Wijngaard, Ido, additional, Dippel, Diederik W, additional, Majoie, Charles B, additional, and Marquering, Henk, additional
Published: 2021
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46. Importance of Occlusion Site for Thrombectomy Technique in Stroke

Author: Bernsen, Marie Louise E., primary, Goldhoorn, Robert-Jan B., additional, Lingsma, Hester F., additional, van Oostenbrugge, Robert J., additional, van Zwam, Wim H., additional, Uyttenboogaart, Maarten, additional, Roos, Yvo B.W.E.M., additional, Martens, Jasper M., additional, Hofmeijer, Jeannette, additional, Dippel, Diederik W.J., additional, van der Lugt, Aad, additional, Majoie, Charles B.L.M., additional, Boiten, Jelis, additional, Albert Vos, Jan, additional, Jansen, Ivo G.H., additional, Mulder, Maxim J.H.L., additional, Goldhoorn, Robert- Jan B., additional, Compagne, Kars C.J., additional, Kappelhof, Manon, additional, Brouwer, Josje, additional, den Hartog, Sanne J., additional, Hinsenveld, Wouter H., additional, Roozenbeek, Bob, additional, van Es, Adriaan C.G.M., additional, Emmer, Bart J., additional, Coutinho, Jonathan M., additional, Schonewille, Wouter J., additional, Wermer, Marieke J.H., additional, van Walderveen, Marianne A.A., additional, Staals, Julie, additional, Lycklama, Geert J., additional, Nijeholt, à, additional, de Bruijn, Sebastiaan F., additional, van Dijk, Lukas C., additional, van der Worp, H. Bart, additional, Lo, Rob H., additional, van Dijk, Ewoud J., additional, Boogaarts, Hieronymus D., additional, Vries, J. de, additional, de Kort, Paul L.M., additional, van Tuijl, Julia, additional, Peluso, Jo P., additional, Fransen, Puck, additional, van den Berg, Jan S.P., additional, van Hasselt, Boudewijn A.A.M., additional, Aerden, Leo A.M., additional, Dallinga, René J., additional, Eschgi, Omid, additional, Bokkers, Reinoud P.H., additional, Schreuder, Tobien H.C.M.L., additional, Heijboer, Roel J.J., additional, Keizer, Koos, additional, Yo, Lonneke S.F., additional, den Hertog, Heleen M., additional, Bulut, Tomas, additional, Brouwers, Paul J.A.M., additional, Sprengers, Marieke E.S., additional, Jenniskens, Sjoerd F.M., additional, van den Berg, René, additional, Yoo, Albert J., additional, Beenen, Ludo F.M., additional, Postma, Alida A., additional, Roosendaal, Stefan D., additional, der Kallen, Bas F.W. van, additional, van den Wijngaard, Ido R., additional, Bot, Joost, additional, van Doormaal, Pieter-Jan, additional, Meijer, Anton, additional, Ghariq, Elyas, additional, van Proosdij, Marc P., additional, Krietemeijer, G. Menno, additional, Lo, Rob, additional, Gerrits, Dick, additional, Dinkelaar, Wouter, additional, Appelman, Auke P.A., additional, Hammer, Bas, additional, Pegge, Sjoert, additional, van der Hoorn, Anouk, additional, Vinke, Saman, additional, Flach, H. Zwenneke, additional, el Ghannouti, Naziha, additional, Sterrenberg, Martin, additional, Pellikaan, Wilma, additional, Sprengers, Rita, additional, Elfrink, Marjan, additional, Simons, Michelle, additional, Vossers, Marjolein, additional, de Meris, Joke, additional, Vermeulen, Tamara, additional, Geerlings, Annet, additional, van Vemde, Gina, additional, Simons, Tiny, additional, Messchendorp, Gert, additional, Nicolaij, Nynke, additional, Bongenaar, Hester, additional, Bodde, Karin, additional, Kleijn, Sandra, additional, Lodico, Jasmijn, additional, Droste, Hanneke, additional, Wollaert, Maureen, additional, Verheesen, Sabrina, additional, Jeurrissen, D., additional, Bos, Erna, additional, Drabbe, Yvonne, additional, Sandiman, Michelle, additional, Aaldering, Nicoline, additional, Zweedijk, Berber, additional, Vervoort, Jocova, additional, Ponjee, Eva, additional, Romviel, Sharon, additional, Kanselaar, Karin, additional, Barning, Denn, additional, Venema, Esmee, additional, Chalos, Vicky, additional, Geuskens, Ralph R., additional, van Straaten, Tim, additional, Ergezen, Saliha, additional, Harmsma, Roger R.M., additional, Muijres, Daan, additional, de Jong, Anouk, additional, Berkhemer, Olvert A., additional, Boers, Anna M.M., additional, Huguet, J., additional, Groot, P.F.C., additional, Mens, Marieke A., additional, van Kranendonk, Katinka R., additional, Treurniet, Kilian M., additional, Tolhuisen, Manon L., additional, Alves, Heitor, additional, Weterings, Annick J., additional, Kirkels, Eleonora L.F., additional, Voogd, Eva J.H.F., additional, Schupp, Lieve M., additional, Collette, Sabine L., additional, Groot, Adrien E.D., additional, LeCouffe, Natalie E., additional, Konduri, Praneeta R., additional, Prasetya, Haryadi, additional, Arrarte-Terreros, Nerea, additional, and Ramos, Lucas A., additional
Published: 2021
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47. Combined Effect of Age and Baseline Alberta Stroke Program Early Computed Tomography Score on Post-Thrombectomy Clinical Outcomes in the MR CLEAN Registry

Author: Ospel, Johanna, primary, Kappelhof, Manon, additional, Groot, Adrien E., additional, LeCouffe, Natalie E., additional, Coutinho, Jonathan M., additional, Yoo, Albert J., additional, Yo, Lonneke S.F., additional, Beenen, Ludo F.M., additional, van Zwam, Wim H., additional, van der Lugt, Aad, additional, Postma, Alida A., additional, Roos, Yvo B.W.E.M., additional, Goyal, Mayank, additional, Majoie, Charles B.L.M., additional, Dippel, Diederik W.J., additional, van Oostenbrugge, Robert J., additional, Boiten, Jelis, additional, Albert Vos, Jan, additional, Jansen, Ivo G.H., additional, Mulder, Maxim J.H.L., additional, Goldhoorn, Robert- Jan B., additional, Compagne, Kars C.J., additional, Brouwer, Josje, additional, den Hartog, Sanne J., additional, Hinsenveld, Wouter H., additional, Roozenbeek, Bob, additional, van Es, Adriaan C.G.M., additional, Emmer, Bart J., additional, Schonewille, Wouter J., additional, Wermer, Marieke J.H., additional, van Walderveen, Marianne A.A., additional, Staals, Julie, additional, Hofmeijer, Jeannette, additional, Martens, Jasper M., additional, Lycklama à Nijeholt, Geert J., additional, de Bruijn, Sebastiaan F., additional, van Dijk, Lukas C., additional, van der Worp, H. Bart, additional, Lo, Rob H., additional, van Dijk, Ewoud J., additional, Boogaarts, Hieronymus D., additional, de Vries, J., additional, de Kort, Paul L.M., additional, van Tuijl, Julia, additional, Peluso, Jo P., additional, Fransen, Puck, additional, van den Berg, Jan S.P., additional, van Hasselt, Boudewijn A.A.M., additional, Aerden, Leo A.M., additional, Dallinga, René J., additional, Uyttenboogaart, Maarten, additional, Eschgi, Omid, additional, Bokkers, Reinoud P.H., additional, Schreuder, Tobien H.C.M.L., additional, Heijboer, Roel J.J., additional, Keizer, Koos, additional, den Hertog, Heleen M., additional, Sturm, Emiel J.C., additional, Brouwers, Paul J.A.M., additional, Sprengers, Marieke E.S., additional, Jenniskens, Sjoerd F.M., additional, van den Berg, René, additional, Roosendaal, Stefan D., additional, van der Kallen, Bas F.W., additional, van den Wijngaard, Ido R., additional, Bot, Joost, additional, van Doormaal, Pieter-Jan, additional, Meijer, Anton, additional, Ghariq, Elyas, additional, van Proosdij, Marc P., additional, Krietemeijer, G. Menno, additional, Lo, Rob, additional, Gerrits, Dick, additional, Dinkelaar, Wouter, additional, Appelman, Auke P.A., additional, Hammer, Bas, additional, Pegge, Sjoert, additional, van der Hoorn, Anouk, additional, Vinke, Saman, additional, Flach, H. Zwenneke, additional, Lingsma, Hester F., additional, Ghannouti, Naziha el, additional, Sterrenberg, Martin, additional, Pellikaan, Wilma, additional, Sprengers, Rita, additional, Elfrink, Marjan, additional, Simons, Michelle, additional, Vossers, Marjolein, additional, de Meris, Joke, additional, Vermeulen, Tamara, additional, Geerlings, Annet, additional, van Vemde, Gina, additional, Simons, Tiny, additional, Messchendorp, Gert, additional, Nicolaij, Nynke, additional, Bongenaar, Hester, additional, Bodde, Karin, additional, Kleijn, Sandra, additional, Lodico, Jasmijn, additional, Droste, Hanneke, additional, Wollaert, Maureen, additional, Verheesen, Sabrina, additional, Jeurrissen, D., additional, Bos, Erna, additional, Drabbe, Yvonne, additional, Sandiman, Michelle, additional, Aaldering, Nicoline, additional, Zweedijk, Berber, additional, Vervoort, Jocova, additional, Ponjee, Eva, additional, Romviel, Sharon, additional, Kanselaar, Karin, additional, Barning, Denn, additional, Venema, Esmee, additional, Chalos, Vicky, additional, Geuskens, Ralph R., additional, van Straaten, Tim, additional, Ergezen, Saliha, additional, Harmsma, Roger R.M., additional, Muijres, Daan, additional, de Jong, Anouk, additional, Berkhemer, Olvert A., additional, Boers, Anna M.M., additional, Huguet, J., additional, Groot, P.F.C., additional, Mens, Marieke A., additional, van Kranendonk, Katinka R., additional, Treurniet, Kilian M., additional, Tolhuisen, Manon L., additional, Alves, Heitor, additional, Weterings, Annick J., additional, Kirkels, Eleonora L.F., additional, Schupp, Lieve M., additional, Voogd, Eva J.H.F., additional, Collette, Sabine, additional, Konduri, Praneeta R., additional, Prasetya, Haryadi, additional, Arrarte-Terreros, Nerea, additional, and Ramos, Lucas A., additional
Published: 2020
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48. Admission Blood Pressure in Relation to Clinical Outcomes and Successful Reperfusion After Endovascular Stroke Treatment

Author: van den Berg, Sophie A., primary, Uniken Venema, Simone M., additional, Mulder, Maxim J.H.L., additional, Treurniet, Kilian M., additional, Samuels, Noor, additional, Lingsma, Hester F., additional, Goldhoorn, Robert-Jan B., additional, Jansen, Ivo G.H., additional, Coutinho, Jonathan M., additional, Roozenbeek, Bob, additional, Dippel, Diederik W.J., additional, Roos, Yvo B.W.E.M., additional, van der Worp, H. Bart, additional, Nederkoorn, Paul J., additional, van der Lugt, Aad, additional, Majoie, Charles B.L.M., additional, van Oostenbrugge, Robert J., additional, van Zwam, Wim H., additional, Vos, Jan Albert, additional, Brouwer, Josje, additional, den Hartog, Sanne J., additional, Hinsenveld, Wouter H., additional, Kappelhof, Manon, additional, Compagne, Kars C.J., additional, van Es, Adriaan C.G.M., additional, Emmer, Bart J., additional, Schonewille, Wouter J., additional, Wermer, Marieke J.H., additional, van Walderveen, Marianne A.A., additional, Staals, Julie, additional, Hofmeijer, Jeannette, additional, Martens, Jasper M., additional, Lycklama à Nijeholt, Geert J., additional, Boiten, Jelis, additional, de Bruijn, Sebastiaan F., additional, van Dijk, Lukas C., additional, Lo, Rob H., additional, van Dijk, Ewoud J., additional, Boogaarts, Hieronymus D., additional, de Vries, J., additional, de Kort, Paul L.M., additional, van Tuijl, Julia, additional, Peluso, Jo P., additional, Fransen, Puck, additional, van den Berg, Jan S.P., additional, van Hasselt, Boudewijn A.A.M., additional, Aerden, Leo A.M., additional, Dallinga, René J., additional, Uyttenboogaart, Maarten, additional, Eschgi, Omid, additional, Bokkers, Reinoud P.H., additional, Schreuder, Tobien H.C.M.L., additional, Heijboer, Roel J.J., additional, Keizer, Koos, additional, Yo, Lonneke S.F., additional, den Hertog, Heleen M., additional, Sturm, Emiel J.C., additional, Brouwers, Paul, additional, Sprengers, Marieke E.S., additional, Jenniskens, Sjoerd F.M., additional, van den Berg, René, additional, Yoo, Albert J., additional, Beenen, Ludo F.M., additional, Postma, Alida A., additional, Roosendaal, Stefan D., additional, van der Kallen, Bas F.W., additional, van den Wijngaard, Ido R., additional, Bot, Joost, additional, van Doormaal, Pieter-Jan, additional, Meijer, Anton, additional, Ghariq, Elyas, additional, van Proosdij, Marc P., additional, Krietemeijer, G. Menno, additional, Lo, Rob, additional, Gerrits, Dick, additional, Dinkelaar, Wouter, additional, Appelman, Auke P.A., additional, Hammer, Bas, additional, Pegge, Sjoert, additional, van der Hoorn, Anouk, additional, Vinke, Saman, additional, Flach, H. Zwenneke, additional, Ghannouti, Naziha el, additional, Sterrenberg, Martin, additional, Puppels, Corina, additional, Pellikaan, Wilma, additional, Sprengers, Rita, additional, Elfrink, Marjan, additional, Simons, Michelle, additional, Vossers, Marjolein, additional, de Meris, Joke, additional, Vermeulen, Tamara, additional, Geerlings, Annet, additional, van Vemde, Gina, additional, Simons, Tiny, additional, van Rijswijk, Cathelijn, additional, Messchendorp, Gert, additional, Nicolaij, Nynke, additional, Bongenaar, Hester, additional, Bodde, Karin, additional, Kleijn, Sandra, additional, Lodico, Jasmijn, additional, Droste, Hanneke, additional, Wollaert, Maureen, additional, Verheesen, Sabrina, additional, Jeurrissen, D., additional, Bos, Erna, additional, Drabbe, Yvonne, additional, Sandiman, Michelle, additional, Aaldering, Nicoline, additional, Zweedijk, Berber, additional, Khalilzada, Mostafa, additional, Vervoort, Jocova, additional, Ponjee, Eva, additional, Romviel, Sharon, additional, Kanselaar, Karin, additional, Barning, Denn, additional, Venema, Esmee, additional, Chalos, Vicky, additional, Geuskens, Ralph R., additional, van Straaten, Tim, additional, Ergezen, Saliha, additional, Harmsma, Roger R.M., additional, Muijres, Daan, additional, de Jong, Anouk, additional, Berkhemer, Olvert A., additional, Boers, Anna M.M., additional, Huguet, J., additional, Groot, P.F.C., additional, Mens, Marieke A., additional, van Kranendonk, Katinka R., additional, Tolhuisen, Manon L., additional, Alves, Heitor, additional, Weterings, Annick J., additional, Kirkels, Eleonora L.F., additional, Voogd, Eva J.H.F., additional, Schupp, Lieve M., additional, Collette, Sabine, additional, Groot, Adrien E.D., additional, LeCouffe, Natalie E., additional, Konduri, Praneeta R., additional, Prasetya, Haryadi, additional, Arrarte-Terreros, Nerea, additional, and Ramos, Lucas A., additional
Published: 2020
Full Text: View/download PDF

49. Path From Clinical Research to Implementation

Author: Wiegers, Eveline J.A., primary, Compagne, Kars C.J., additional, Janssen, Paula M., additional, Venema, Esmee, additional, Deckers, Jaap W., additional, Schonewille, Wouter J., additional, Albert Vos, Jan, additional, Lycklama à Nijeholt, Geert J., additional, Roozenbeek, Bob, additional, Martens, Jasper M., additional, Hofmeijer, Jeannette, additional, van Oostenbrugge, Robert-Jan, additional, van Zwam, Wim H., additional, Majoie, Charles B.L.M., additional, van der Lugt, Aad, additional, Lingsma, H.F., additional, Roos, Yvo B.W.E.M., additional, Dippel, Diederik W.J., additional, Boiten, Jelis, additional, Brouwer, Josje, additional, den Hartog, Sanne J., additional, Hinsenveld, Wouter H., additional, Kappelhof, Manon, additional, Goldhoorn, Robert-Jan B., additional, Mulder, Maxim J.H.L., additional, Jansen, Ivo G.H., additional, van Es, Adriaan C.G.M., additional, Emmer, Bart J., additional, Coutinho, Jonathan M., additional, Wermer, Marieke J.H., additional, van Walderveen, Marianne A.A., additional, Staals, Julie, additional, de Bruijn, Sebastiaan F., additional, van Dijk, Lukas C., additional, van der Worp, H. Bart, additional, Lo, Rob H., additional, van Dijk, Ewoud J., additional, Boogaarts, Hieronymus D., additional, Vries, J. de, additional, de Kort, Paul L.M., additional, van Tuijl, Julia, additional, Peluso, Jo Jo P., additional, Fransen, Puck, additional, van den Berg, Jan S.P., additional, van Hasselt, Boudewijn A.A.M., additional, Aerden, Leo A.M., additional, Dallinga, René J., additional, Uyttenboogaart, Maarten, additional, Eschgi, Omid, additional, Bokkers, Reinoud P.H., additional, Schreuder, Tobien H.C.M.L., additional, Heijboer, Roel J.J., additional, Keizer, Koos, additional, Yo, Lonneke S.F., additional, den Hertog, Heleen M., additional, Sturm, Emiel J.C., additional, Brouwers, Paul, additional, Sprengers, Marieke E.S., additional, Jenniskens, Sjoerd F.M., additional, van den Berg, René, additional, Yoo, Albert J., additional, Beenen, Ludo F.M., additional, Postma, Alida A., additional, Roosendaal, Stefan D., additional, van der Kallen, Bas F.W., additional, van den Wijngaard, Ido R., additional, Bot, Joost, additional, van Doormaal, Pieter-Jan, additional, Meijer, Anton, additional, Ghariq, Elyas, additional, van Proosdij, Marc P., additional, Krietemeijer, G. Menno, additional, Peluso, Jo P., additional, Lo, Rob, additional, Gerrits, Dick, additional, Dinkelaar, Wouter, additional, Appelman, Auke P.A., additional, Hammer, Bas, additional, Pegge, Sjoert, additional, van der Hoorn, Anouk, additional, Vinke, Saman, additional, Flach, H. Zwenneke, additional, Ghannouti, Naziha el, additional, Sterrenberg, Martin, additional, Puppels, Corina, additional, Pellikaan, Wilma, additional, Sprengers, Rita, additional, Elfrink, Marjan, additional, Simons, Michelle, additional, Vossers, Marjolein, additional, de Meris, Joke, additional, Vermeulen, Tamara, additional, Geerlings, Annet, additional, van Vemde, Gina, additional, Simons, Tiny, additional, van Rijswijk, Cathelijn, additional, Messchendorp, Gert, additional, Nicolaij, Nynke, additional, Bongenaar, Hester, additional, Bodde, Karin, additional, Kleijn, Sandra, additional, Lodico, Jasmijn, additional, Droste, Hanneke, additional, Wollaert, Maureen, additional, Verheesen, Sabrina, additional, Jeurrissen, D., additional, Bos, Erna, additional, Drabbe, Yvonne, additional, Sandiman, Michelle, additional, Aaldering, Nicoline, additional, Zweedijk, Berber, additional, Khalilzada, Mostafa, additional, Vervoort, Jocova, additional, Ponjee, Eva, additional, Romviel, Sharon, additional, Kanselaar, Karin, additional, Barning, Denn, additional, Chalos, Vicky, additional, Geuskens, Ralph R., additional, van Straaten, Tim, additional, Ergezen, Saliha, additional, Harmsma, Roger R.M., additional, Muijres, Daan, additional, de Jong, Anouk, additional, Berkhemer, Olvert A., additional, Boers, Anna M.M., additional, Huguet, J., additional, Groot, P.F.C., additional, Mens, Marieke A., additional, van Kranendonk, Katinka R., additional, Treurniet, Kilian M., additional, Tolhuisen, Manon L., additional, Alves, Heitor, additional, Weterings, Annick J., additional, Kirkels, Eleonora L.F., additional, Voogd, Eva J.H.F., additional, Schupp, Lieve M., additional, Collette, Sabine, additional, Groot, Adrien E.D., additional, LeCouffe, Natalie E., additional, Konduri, Praneeta R., additional, Prasetya, Haryadi, additional, Arrarte-Terreros, Nerea, additional, and Ramos, Lucas A., additional
Published: 2020
Full Text: View/download PDF

50. Clinical and Imaging Determinants of Collateral Status in Patients With Acute Ischemic Stroke in MR CLEAN Trial and Registry

Author: Wiegers, Eveline J.A., primary, Mulder, Maxim J.H.L., additional, Jansen, Ivo G.H., additional, Venema, Esmee, additional, Compagne, Kars C.J., additional, Berkhemer, Olvert A., additional, Emmer, Bart J., additional, Marquering, Henk A., additional, van Es, Adriaan C.G.M., additional, Sprengers, Marieke E., additional, van Zwam, Wim H., additional, van Oostenbrugge, Robert J., additional, Roos, Yvo B.W.E.M., additional, Majoie, Charles B.L.M., additional, Roozenbeek, Bob, additional, Lingsma, Hester F., additional, Dippel, Diederik W.J., additional, van der Lugt, Aad, additional, Boiten, Jelis, additional, Vos, Jan Albert, additional, Brouwer, Josje, additional, den Hartog, Sanne J., additional, Hinsenveld, Wouter H., additional, Kappelhof, Manon, additional, Goldhoorn, Robert-Jan B., additional, Coutinho, Jonathan M., additional, Schonewille, Wouter J., additional, Wermer, Marieke J.H., additional, van Walderveen, Marianne A.A., additional, Staals, Julie, additional, Hofmeijer, Jeannette, additional, Martens, Jasper M., additional, Lycklama à Nijeholt, Geert J., additional, de Bruijn, Sebastiaan F., additional, van Dijk, Lukas C., additional, van der Worp, H. Bart, additional, Lo, Rob H., additional, van Dijk, Ewoud J., additional, Boogaarts, Hieronymus D., additional, de Vries, J., additional, de Kort, Paul L.M., additional, van Tuijl, Julia, additional, Peluso, Jo Jo P., additional, Fransen, Puck, additional, van den Berg, Jan S.P., additional, van Hasselt, Boudewijn A.A.M., additional, Aerden, Leo A.M., additional, Dallinga, René J., additional, Uyttenboogaart, Maarten, additional, Eschgi, Omid, additional, Bokkers, Reinoud P.H., additional, Schreuder, Tobien H.C.M.L., additional, Heijboer, Roel J.J., additional, Keizer, Koos, additional, Yo, Lonneke S.F., additional, den Hertog, Heleen M., additional, Sturm, Emiel J.C., additional, Brouwers, Paul, additional, Jenniskens, Sjoerd F.M., additional, van den Berg, René, additional, Yoo, Albert J., additional, Beenen, Ludo F.M., additional, Postma, Alida A., additional, Roosendaal, Stefan D., additional, van der Kallen, Bas F.W., additional, van den Wijngaard, Ido R., additional, Bot, Joost, additional, van Doormaal, Pieter-Jan, additional, Meijer, Anton, additional, Ghariq, Elyas, additional, van Proosdij, Marc P., additional, Krietemeijer, G. Menno, additional, Peluso, Jo P., additional, Lo, Rob, additional, Gerrits, Dick, additional, Dinkelaar, Wouter, additional, Appelman, Auke P.A., additional, Hammer, Bas, additional, Pegge, Sjoert, additional, van der Hoorn, Anouk, additional, Vinke, Saman, additional, Flach, H. Zwenneke, additional, el Ghannouti, Naziha, additional, Sterrenberg, Martin, additional, Puppels, Corina, additional, Pellikaan, Wilma, additional, Sprengers, Rita, additional, Elfrink, Marjan, additional, Simons, Michelle, additional, Vossers, Marjolein, additional, de Meris, Joke, additional, Vermeulen, Tamara, additional, Geerlings, Annet, additional, van Vemde, Gina, additional, Simons, Tiny, additional, van Rijswijk, Cathelijn, additional, Messchendorp, Gert, additional, Nicolaij, Nynke, additional, Bongenaar, Hester, additional, Bodde, Karin, additional, Kleijn, Sandra, additional, Lodico, Jasmijn, additional, Droste, Hanneke, additional, Wollaert, Maureen, additional, Verheesen, Sabrina, additional, Jeurrissen, D., additional, Bos, Erna, additional, Drabbe, Yvonne, additional, Sandiman, Michelle, additional, Aaldering, Nicoline, additional, Zweedijk, Berber, additional, Khalilzada, Mostafa, additional, Vervoort, Jocova, additional, Ponjee, Eva, additional, Romviel, Sharon, additional, Kanselaar, Karin, additional, Barning, Denn, additional, Chalos, Vicky, additional, Geuskens, Ralph R., additional, van Straaten, Tim, additional, Ergezen, Saliha, additional, Harmsma, Roger R.M., additional, Muijres, Daan, additional, de Jong, Anouk, additional, Boers, Anna M.M., additional, Huguet, J., additional, Groot, P.F.C., additional, Mens, Marieke A., additional, van Kranendonk, Katinka R., additional, Treurniet, Kilian M., additional, Tolhuisen, Manon L., additional, Alves, Heitor, additional, Weterings, Annick J., additional, Kirkels, Eleonora L.F., additional, Voogd, Eva J.H.F., additional, Schupp, Lieve M., additional, Collette, Sabine, additional, Groot, Adrien E.D., additional, LeCouffe, Natalie E., additional, Konduri, Praneeta R., additional, Prasetya, Haryadi, additional, Arrarte-Terreros, Nerea, additional, and Ramos, Lucas A., additional
Published: 2020
Full Text: View/download PDF

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