38 results on '"Brouwer, Iman"'
Search Results
2. Reliability of brain atrophy measurements in multiple sclerosis using MRI: an assessment of six freely available software packages for cross-sectional analyses
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van Nederpelt, David R., Amiri, Houshang, Brouwer, Iman, Noteboom, Samantha, Mokkink, Lidwine B., Barkhof, Frederik, Vrenken, Hugo, and Kuijer, Joost P. A.
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- 2023
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3. Validation of a semi-automated method to quantify lesion volume changes in multiple sclerosis on 2D proton-density-weighted scans based on image subtraction
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Mattiesing, Rozemarijn M., Stel, Serena, Mangroe, Alysha S., Brouwer, Iman, Versteeg, Adriaan, van Schijndel, Ronald A., Uitdehaag, Bernard M.J., Barkhof, Frederik, Vrenken, Hugo, and Kuijer, Joost P.A.
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- 2024
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4. Tau pathology as determinant of changes in atrophy and cerebral blood flow: a multi-modal longitudinal imaging study
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Visser, Denise, Verfaillie, Sander C. J., Bosch, Iris, Brouwer, Iman, Tuncel, Hayel, Coomans, Emma M., Rikken, Roos M., Mastenbroek, Sophie E., Golla, Sandeep S. V., Barkhof, Frederik, van de Giessen, Elsmarieke, van Berckel, Bart N. M., van der Flier, Wiesje M., and Ossenkoppele, Rik
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- 2023
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5. The spatio-temporal relationship between concurrent lesion and brain atrophy changes in early multiple sclerosis: A post-hoc analysis of the REFLEXION study
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Gentile, Giordano, Mattiesing, Rozemarijn M., Brouwer, Iman, van Schijndel, Ronald A., Uitdehaag, Bernard M.J., Twisk, Jos W.R., Kappos, Ludwig, Freedman, Mark S., Comi, Giancarlo, Jack, Dominic, Barkhof, Frederik, De Stefano, Nicola, Vrenken, Hugo, and Battaglini, Marco
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- 2023
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6. The effect of gadolinium-based contrast-agents on automated brain atrophy measurements by FreeSurfer in patients with multiple sclerosis
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Lie, Ingrid Anne, Kerklingh, Emma, Wesnes, Kristin, van Nederpelt, David R., Brouwer, Iman, Torkildsen, Øivind, Myhr, Kjell-Morten, Barkhof, Frederik, Bø, Lars, and Vrenken, Hugo
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- 2022
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7. The spatio-temporal relationship between white matter lesion volume changes and brain atrophy in clinically isolated syndrome and early multiple sclerosis
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Mattiesing, Rozemarijn M., Gentile, Giordano, Brouwer, Iman, van Schijndel, Ronald A., Uitdehaag, Bernard M.J., Twisk, Jos W.R., Kappos, Ludwig, Freedman, Mark S., Comi, Giancarlo, Jack, Dominic, De Stefano, Nicola, Barkhof, Frederik, Battaglini, Marco, and Vrenken, Hugo
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- 2022
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8. Scanner-Specific Optimisation of Automated Lesion Segmentation in MS
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Nederpelt, van, David Rudolf, primary, Pontillo, Giuseppe, additional, Barrantes-Cepas, Mar, additional, Brouwer, Iman, additional, Strijbis, Eva, additional, Schoonheim, Menno M., additional, Moraal, Bastiaan, additional, Jasperse, Bas, additional, Mutsaerts, Henk-Jan M.M., additional, Killestein, Joep, additional, Barkhof, Frederik, additional, Kuijer, Joost P.A., additional, and Vrenken, Hugo, additional
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- 2024
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9. Disease progression in the first 5 years of treatment in multiple sclerosis: Predictive value of early brain and lesion volume changes
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Mattiesing, Rozemarijn M, primary, Kramer, Eline, additional, Strijbis, Eva MM, additional, Brouwer, Iman, additional, van Schijndel, Ronald A, additional, Gentile, Giordano, additional, Battaglini, Marco, additional, De Stefano, Nicola, additional, Uitdehaag, Bernard MJ, additional, Barkhof, Frederik, additional, Vrenken, Hugo, additional, and Schoonheim, Menno M, additional
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- 2023
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10. Disease progression in the first 5 years of treatment in multiple sclerosis: Predictive value of early brain and lesion volume changes.
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Mattiesing, Rozemarijn M, Kramer, Eline, Strijbis, Eva MM, Brouwer, Iman, van Schijndel, Ronald A, Gentile, Giordano, Battaglini, Marco, De Stefano, Nicola, Uitdehaag, Bernard MJ, Barkhof, Frederik, Vrenken, Hugo, and Schoonheim, Menno M
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BRAIN damage ,DISEASE progression ,MULTIPLE sclerosis ,MAGNETIC resonance imaging ,THERAPEUTICS - Abstract
Background: Whether the degree of inflammation (and its resolution) and neurodegeneration after treatment initiation predicts disease progression in multiple sclerosis (MS) remains unclear. Objectives: To assess the predictive value of magnetic resonance imaging (MRI)-derived brain and lesion volume (LV) changes in years 1 and 2 of treatment for disease progression. Methods: Patients receiving early interferon beta-1a treatment in REFLEX/REFLEXION (N = 262) were included. Predictive regression models included new/enlarging LV (positive activity), disappearing/shrinking LV (negative activity), and global/central atrophy during years 1 and 2. Results: Faster global atrophy and/or pseudo-atrophy and positive lesion activity in years 1 and 2 related to an increased probability and faster conversion to clinically definite multiple sclerosis (CDMS). Negative lesion activity in year 1 and slower central atrophy in year 2 were predictive of confirmed disability progression (9-Hole Peg Test). Positive lesion activity in year 2 was predictive of faster global atrophy, while positive lesion activity in years 1 and 2 was predictive of faster central atrophy. Conclusions: A higher degree of global atrophy and/or pseudo-atrophy in year 1 was predictive of CDMS. Positive lesion activity in any year was related to CDMS and neurodegeneration. Disability was related to negative lesion activity in year 1 and slower central atrophy in year 2. [ABSTRACT FROM AUTHOR]
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- 2024
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11. The Effect of Smoking on Long-term Gray Matter Atrophy and Clinical Disability in Patients with Relapsing-Remitting Multiple Sclerosis
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Lie, Ingrid Anne, primary, Wesnes, Kristin, additional, Kvistad, Silje S., additional, Brouwer, Iman, additional, Wergeland, Stig, additional, Holmøy, Trygve, additional, Midgard, Rune, additional, Bru, Alla, additional, Edland, Astrid, additional, Eikeland, Randi, additional, Gosal, Sonia, additional, Harbo, Hanne F., additional, Kleveland, Grethe, additional, Sørenes, Yvonne S., additional, Øksendal, Nina, additional, Barkhof, Frederik, additional, Vrenken, Hugo, additional, Myhr, Kjell-Morten, additional, Bø, Lars, additional, and Torkildsen, Øivind, additional
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- 2022
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12. Predicting cortical thickness with [18F]flortaucipir PET: A longitudinal MRI study.
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Visser, Denise, Ossenkoppele, Rik, Bosch, Iris W.M., Brouwer, Iman, Tuncel, Hayel, Coomans, Emma M., Rikken, Roos M., Mastenbroek, Sophie E, Verfaillie, Sander C.J., Golla, Sandeep S.V., Barkhof, Frederik, van der Flier, Wiesje M., and van Berckel, Bart N.M.
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Background: The association between tau pathology and neurodegeneration (atrophy) in Alzheimer's disease (AD) is not fully understood. This study aimed to investigate whether tau pathology is associated with concurrent and longitudinal cortical thickness in individuals along the AD continuum. Method: We included 92 amyloid‐positive cognitively impaired individuals (age 65±7, 48% female, MMSE 23±4) with AD dementia (n = 73) or mild cognitive impairment due to AD (MCI, n = 19) and 61 cognitively normal individuals (CN; age 66±8, 48% female, MMSE 29±1) with subjective cognitive decline (SCD, n = 55, 19 amyloid‐positive) or healthy controls (HC, n = 6, amyloid‐status unknown). All participants underwent dynamic [18F]flortaucipir PET and structural 3T‐MRI at baseline. A subset underwent two‐year follow‐up structural 3T‐MRI (CN: n = 35, time‐interval 24±8 months; AD: n = 26; time‐interval 28±4 months). Parametric [18F]flortaucipir binding potential (BPND) images were generated using receptor parametric mapping (cerebellar gray matter reference region) to quantify tau pathology. Cortical thickness (over time) was measured using Freesurfer (version 6.0.1). Regional associations between [18F]flortaucipir BPND and cortical thickness were assessed using linear mixed models in three commonly used a priori defined regions‐of‐interest, including entorhinal, middle‐and inferior temporal, and neocortical areas. Models were adjusted for age, sex and amyloid status (in case of CN individuals). Result: For cognitively impaired individuals, higher [18F]flortaucipir BPND (in all three regions) was associated with lower concurrent cortical thickness in the entorhinal cortex [Table‐1&Fig‐1]. Higher middle‐ and inferior temporal and neocortical BPND was associated with cortical thinning over time within the same region (intra‐regionally). Higher middle‐ and inferior temporal BPND additionally showed associations with cortical thinning over time in the neocortex (inter‐regionally). For cognitively normal individuals, we found no associations between [18F]flortaucipir BPND and cortical thickness (over time) [Table‐1&Figure‐1]. Conclusion: Tau pathology is associated with both concurrent and longitudinal atrophy in a region‐specific manner in cognitively impaired individuals (MCI/AD), but not in cognitively normal individuals (HC/SCD). The regional‐specificity of these associations might suggest that there are similarities between tau‐related progression patterns and patterns of neurodegeneration. Taking into account a temporal delay between the development of region‐specific tau pathology and neurodegeneration, this potentially suggests that tau pathology is a (partial) driver of neurodegeneration in AD. [ABSTRACT FROM AUTHOR]
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- 2023
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13. Serum neurofilament as a predictor of 10-year grey matter atrophy and clinical disability in multiple sclerosis: a longitudinal study
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Lie, Ingrid Anne, primary, Kaçar, Sezgi, additional, Wesnes, Kristin, additional, Brouwer, Iman, additional, Kvistad, Silje S, additional, Wergeland, Stig, additional, Holmøy, Trygve, additional, Midgard, Rune, additional, Bru, Alla, additional, Edland, Astrid, additional, Eikeland, Randi, additional, Gosal, Sonia, additional, Harbo, Hanne F, additional, Kleveland, Grethe, additional, Sørenes, Yvonne S, additional, Øksendal, Nina, additional, Varhaug, Kristin N, additional, Vedeler, Christian A, additional, Barkhof, Frederik, additional, Teunissen, Charlotte E, additional, Bø, Lars, additional, Torkildsen, Øivind, additional, Myhr, Kjell-Morten, additional, and Vrenken, Hugo, additional
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- 2022
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14. Upper cervical cord atrophy is independent of cervical cord lesion volume in early multiple sclerosis: A two-year longitudinal study
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Weeda, Merlin M., primary, Zywicki, Sofia, additional, Brouwer, Iman, additional, Moraal, Bastiaan, additional, Killestein, Joep, additional, Gallo, Paolo, additional, Barkhof, Frederik, additional, Pouwels, Petra J.W., additional, and Vrenken, Hugo, additional
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- 2022
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15. Quantification of Cervical Cord Cross-Sectional Area: Which Acquisition, Vertebra Level, and Analysis Software? A Multicenter Repeatability Study on a Traveling Healthy Volunteer
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Lukas, Carsten, Bellenberg, Barbara, Prados Carrasco, Ferran, Valsasina, Paola, Parmar, Katrin, Brouwer, Iman, Pareto, Deborah, Rovira, Àlex, Sastre Garriga, Jaume, Wheeler-Kingshott, Claudia A. M. Gandini, Kappos, Ludwig, Rocca, Maria A., Filippi, Massimo, Yiannakas, Marios, Barkhof, Frederik, Vrenken, Hugo, Lukas, Carsten, Bellenberg, Barbara, Prados, Ferran, Valsasina, Paola, Parmar, Katrin, Brouwer, Iman, Pareto, Deborah, Rovira, Àlex, Sastre-Garriga, Jaume, Gandini Wheeler-Kingshott, Claudia A. M., Kappos, Ludwig, Rocca, Maria A., Filippi, Massimo, Yiannakas, Mario, Barkhof, Frederik, Vrenken, Hugo, Universitat Oberta de Catalunya (UOC), and Universitat Oberta de Catalunya. eHealth Center
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Neurology ,atrophy ,cord segmentation software ,cross-sectional area ,spinal cord ,cervical cord ,CSA ,multiple sclerosis ,Original Research ,MRI - Abstract
Background: Considerable spinal cord (SC) atrophy occurs in multiple sclerosis (MS). While MRI-based techniques for SC cross-sectional area (CSA) quantification have improved over time, there is no common agreement on whether to measure at single vertebral levels or across larger regions and whether upper SC CSA can be reliably measured from brain images. Aim: To compare in a multicenter setting three CSA measurement methods in terms of repeatability at different anatomical levels. To analyze the agreement between measurements performed on the cervical cord and on brain MRI. Method: One healthy volunteer was scanned three times on the same day in six sites (three scanner vendors) using a 3T MRI protocol including sagittal 3D T1-weighted imaging of the brain (covering the upper cervical cord) and of the SC. Images were analyzed using two semiautomated methods [NeuroQLab (NQL) and the Active Surface Model (ASM)] and the fully automated Spinal Cord Toolbox (SCT) on different vertebral levels (C1-C2; C2/3) on SC and brain images and the entire cervical cord (C1-C7) on SC images only. Results: CSA estimates were significantly smaller using SCT compared to NQL and ASM (p < 0.001), regardless of the cord level. Inter-scanner repeatability was best in C1-C7: coefficients of variation for NQL, ASM, and SCT: 0.4, 0.6, and 1.0%, respectively. CSAs estimated in brain MRI were slightly lower than in SC MRI (all p >_ 0.006 at the C1-C2 level). Despite protocol harmonization between the centers with regard to image resolution and use of high-contrast 3D T1-weighted sequences, the variability of CSA was partly scanner dependent probably due to differences in scanner geometry, coil design, and details of the MRI parameter settings. Conclusion: For CSA quantification, dedicated isotropic SC MRI should be acquired, which yielded best repeatability in the entire cervical cord. In the upper part of the cervical cord, use of brain MRI scans entailed only a minor loss of CSA repeatability compared to SC MRI. Due to systematic differences between scanners and the CSA quantification software, both should be kept constant within a study. The MRI dataset of this study is available publicly to test new analysis approaches.
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- 2021
16. Quantification of cervical cord cross-sectional Area: which acquisition, vertebra level, and analysis software?
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Lukas, Carsten (Prof. Dr. med.), Bellenberg, Barbara (Dr. rer. medic.), Prados, Ferran (PhD), Valsasina, Paola (M. Sc.), Parmar, Katrin (PD Dr. med.), Brouwer, Iman, Pareto, Deborah (PhD), Rovira, Àlex, Sastre-Garriga, Jaume (Dr.), Gandini Wheeler-Kingshott, Claudia A. M. (Prof. Dr.), Kappos, Ludwig (Prof. Dr. med.), Rocca, Maria A., Filippi, Massimo (Prof. Dr. med.), Yiannakas, Marios (PhD), Barkhof, Frederik, and Vrenken, Hugo
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ddc:610 - Abstract
\(\bf Background:\) Considerable spinal cord (SC) atrophy occurs in multiple sclerosis (MS). While MRI-based techniques for SC cross-sectional area (CSA) quantification have improved over time, there is no common agreement on whether to measure at single vertebral levels or across larger regions and whether upper SC CSA can be reliably measured from brain images. \(\bf Aim:\) To compare in a multicenter setting three CSA measurement methods in terms of repeatability at different anatomical levels. To analyze the agreement between measurements performed on the cervical cord and on brain MRI. \(\bf Method:\) One healthy volunteer was scanned three times on the same day in six sites (three scanner vendors) using a 3T MRI protocol including sagittal 3D T1-weighted imaging of the brain (covering the upper cervical cord) and of the SC. Images were analyzed using two semiautomated methods [NeuroQLab (NQL) and the Active Surface Model (ASM)] and the fully automated Spinal Cord Toolbox (SCT) on different vertebral levels (C1–C2; C2/3) on SC and brain images and the entire cervical cord (C1–C7) on SC images only. \(\bf Results:\) CSA estimates were significantly smaller using SCT compared to NQL and ASM (\(\it p\) < 0.001), regardless of the cord level. Inter-scanner repeatability was best in C1–C7: coefficients of variation for NQL, ASM, and SCT: 0.4, 0.6, and 1.0%, respectively. CSAs estimated in brain MRI were slightly lower than in SC MRI (all p ≤ 0.006 at the C1–C2 level). Despite protocol harmonization between the centers with regard to image resolution and use of high-contrast 3D T1-weighted sequences, the variability of CSA was partly scanner dependent probably due to differences in scanner geometry, coil design, and details of the MRI parameter settings. \(\bf Conclusion:\) For CSA quantification, dedicated isotropic SC MRI should be acquired, which yielded best repeatability in the entire cervical cord. In the upper part of the cervical cord, use of brain MRI scans entailed only a minor loss of CSA repeatability compared to SC MRI. Due to systematic differences between scanners and the CSA quantification software, both should be kept constant within a study. The MRI dataset of this study is available publicly to test new analysis approaches.
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- 2021
17. Reduced accuracy of MRI deep grey matter segmentation in multiple sclerosis : an evaluation of four automated methods against manual reference segmentations in a multi-center cohort
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de Sitter, Alexandra, Verhoeven, Tom, Burggraaff, Jessica, Liu, Yaou, Simoes, Jorge, Ruggieri, Serena, Palotai, Miklos, Brouwer, Iman, Versteeg, Adriaan, Wottschel, Viktor, Ropele, Stefan, Rocca, Mara A., Gasperini, Claudio, Gallo, Antonio, Yiannakas, Marios C., Rovira, Alex, Enzinger, Christian, Filippi, Massimo, De Stefano, Nicola, Kappos, Ludwig, Frederiksen, Jette L., Uitdehaag, Bernard M. J., Barkhof, Frederik, Guttmann, Charles R. G., Vrenken, Hugo, Universitat Autònoma de Barcelona, de Sitter, Alexandra, Verhoeven, Tom, Burggraaff, Jessica, Liu, Yaou, Simoes, Jorge, Ruggieri, Serena, Palotai, Miklo, Brouwer, Iman, Versteeg, Adriaan, Wottschel, Viktor, Ropele, Stefan, Rocca, Mara A, Gasperini, Claudio, Gallo, Antonio, Yiannakas, Marios C, Rovira, Alex, Enzinger, Christian, Filippi, Massimo, De Stefano, Nicola, Kappos, Ludwig, Frederiksen, Jette L, Uitdehaag, Bernard M J, Barkhof, Frederik, Guttmann, Charles R G, Vrenken, Hugo, de Sitter, A., Verhoeven, T., Burggraaff, J., Liu, Y., Simoes, J., Ruggieri, S., Palotai, M., Brouwer, I., Versteeg, A., Wottschel, V., Ropele, S., Rocca, M. A., Gasperini, C., Gallo, A., Yiannakas, M. C., Rovira, A., Enzinger, C., Filippi, M., De Stefano, N., Kappos, L., Frederiksen, J. L., Uitdehaag, B. M. J., Barkhof, F., Guttmann, C. R. G., Vrenken, H., Radiology and nuclear medicine, Neurology, and Amsterdam Neuroscience - Brain Imaging
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Correlation coefficient ,Caudate nucleus ,Grey matter ,030218 nuclear medicine & medical imaging ,Multiple sclerosis ,03 medical and health sciences ,0302 clinical medicine ,Atrophy ,Automated segmentation methods ,Deep grey matter ,Medicine ,Humans ,Segmentation ,Multiple sclerosi ,Gray Matter ,Neuroradiology ,Original Communication ,business.industry ,Putamen ,Brain ,medicine.disease ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,Neurology ,Brain size ,Automated segmentation method ,Neurology (clinical) ,business ,Nuclear medicine ,030217 neurology & neurosurgery ,Human - Abstract
Background Deep grey matter (DGM) atrophy in multiple sclerosis (MS) and its relation to cognitive and clinical decline requires accurate measurements. MS pathology may deteriorate the performance of automated segmentation methods. Accuracy of DGM segmentation methods is compared between MS and controls, and the relation of performance with lesions and atrophy is studied. Methods On images of 21 MS subjects and 11 controls, three raters manually outlined caudate nucleus, putamen and thalamus; outlines were combined by majority voting. FSL-FIRST, FreeSurfer, Geodesic Information Flow and volBrain were evaluated. Performance was evaluated volumetrically (intra-class correlation coefficient (ICC)) and spatially (Dice similarity coefficient (DSC)). Spearman's correlations of DSC with global and local lesion volume, structure of interest volume (ROIV), and normalized brain volume (NBV) were assessed. Results ICC with manual volumes was mostly good and spatial agreement was high. MS exhibited significantly lower DSC than controls for thalamus and putamen. For some combinations of structure and method, DSC correlated negatively with lesion volume or positively with NBV or ROIV. Lesion-filling did not substantially change segmentations. Conclusions Automated methods have impaired performance in patients. Performance generally deteriorated with higher lesion volume and lower NBV and ROIV, suggesting that these may contribute to the impaired performance.
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- 2020
18. Quantification of Cervical Cord Cross-Sectional Area: Which Acquisition, Vertebra Level, and Analysis Software? A Multicenter Repeatability Study on a Traveling Healthy Volunteer
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Lukas, Carsten, primary, Bellenberg, Barbara, additional, Prados, Ferran, additional, Valsasina, Paola, additional, Parmar, Katrin, additional, Brouwer, Iman, additional, Pareto, Deborah, additional, Rovira, Àlex, additional, Sastre-Garriga, Jaume, additional, Gandini Wheeler-Kingshott, Claudia A. M., additional, Kappos, Ludwig, additional, Rocca, Maria A., additional, Filippi, Massimo, additional, Yiannakas, Marios, additional, Barkhof, Frederik, additional, and Vrenken, Hugo, additional
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- 2021
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19. Manual and automated tissue segmentation confirm the impact of thalamus atrophy on cognition in multiple sclerosis: A multicenter study
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Burggraaff, Jessica, Liu, Yao, Prieto, Juan C., Simoes, Jorge, de Sitter, Alexandra, Ruggieri, Serena, Brouwer, Iman, Lissenberg-Witte, Birgit I., Rocca, Mara A., Valsasina, Paola, Ropele, Stefan, Gasperini, Claudio, Gallo, Antonio, Pareto, Deborah, Sastre-Garriga, Jaume, Enzinger, Christian, Filippi, Massimo, De Stefano, Nicola, Ciccarelli, Olga, Hulst, Hanneke E., Wattjes, Mike P., Barkhof, Frederik, Uitdehaag, Bernard M. J., Vrenken, Hugo, Guttmann, Charles R. G., Universitat Autònoma de Barcelona, Neurology, Amsterdam Neuroscience - Neuroinfection & -inflammation, Radiology and nuclear medicine, Amsterdam Neuroscience - Brain Imaging, Epidemiology and Data Science, Anatomy and neurosciences, Other Research, APH - Methodology, UCL - (SLuc) Centre du cancer, UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, Institut Català de la Salut, [Burggraaff J, Simoes J] Department of Neurology, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Location VUmc, De Boelelaan 1117, 1118, 1081 HV Amsterdam, The Netherlands. [Liu Y, de Sitter A] Department of Radiology and Nuclear Medicine, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Location VUmc, De Boelelaan 1117, 1118, 1081 HV Amsterdam, The Netherlands. [Prieto JC] Center for Neurological Imaging, Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, 1249 Boylston Street, Boston, MA 02215, USA. [Ruggieri S] Department of Human Neurosciences, 'Sapienza' University of Rome, Piazzale Aldo Moro, 5, 00185 Roma RM, Italy. Department of Neurosciences, San Camillo Forlanini Hospital, Circonvallazione Gianicolense, 87, 00152 Roma RM, Italy. [Pareto D] Secció de Neuroradiologia, Unitat de Ressonància Magnètica, Departament de Radiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Sastre-Garriga J] Servei de Neurologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain, Vall d'Hebron Barcelona Hospital Campus, Burggraaff, J., Liu, Y., Prieto, J. C., Simoes, J., de Sitter, A., Ruggieri, S., Brouwer, I., Lissenberg-Witte, B. I., Rocca, M. A., Valsasina, P., Ropele, S., Gasperini, C., Gallo, A., Pareto, D., Sastre-Garriga, J., Enzinger, C., Filippi, M., De Stefano, N., Ciccarelli, O., Hulst, H. E., Wattjes, M. P., Barkhof, F., Uitdehaag, B. M. J., Vrenken, H., and Guttmann, C. R. G.
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WLG, Word List Generation ,SPM12, Statistical Parametric Mapping 12 ,Audiology ,Tàlem - Imatgeria ,Etiv, estimated total intracranial volume ,lcsh:RC346-429 ,Otros calificadores::Otros calificadores::/complicaciones [Otros calificadores] ,GIF, Geodesic Information Flows ,0302 clinical medicine ,Cognition ,Segmentation ,Thalamus ,CP, cognitively preserved ,NBV, Normalized brain volume ,Multiple Sclerosi ,Other subheadings::/diagnosis [Other subheadings] ,Neuropsychological assessment ,Cognitive decline ,Generalized estimating equation ,WMV, white matter volume ,ICC, intraclass correlation coefficient ,medicine.diagnostic_test ,05 social sciences ,Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis [DISEASES] ,sistema nervioso::sistema nervioso central::encéfalo::prosencéfalo::diencéfalo::tálamo [ANATOMÍA] ,Regular Article ,Neuropsychological test ,HC, healthy control ,SDMT, Symbol Digit Modalities Test ,Magnetic Resonance Imaging ,Neurology ,PASAT, Paced Auditory Serial Addition Test ,enfermedades del sistema nervioso::enfermedades autoinmunitarias del sistema nervioso::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltiple [ENFERMEDADES] ,lcsh:R858-859.7 ,VolBrain, MRI Brain Volumetry System ,SRT, Selective Reminding Test ,Human ,MRI ,Esclerosi múltiple - Complicacions ,medicine.medical_specialty ,CNR, contrast-to-noise ratio ,Multiple Sclerosis ,Cognitive Neuroscience ,RRMS, Relapsing-Remitting Multiple Sclerosis ,Otros calificadores::/diagnóstico [Otros calificadores] ,Nervous System::Central Nervous System::Brain::Prosencephalon::Diencephalon::Thalamus [ANATOMY] ,10/36 SRT, 10/36 Spatial Recall Test ,lcsh:Computer applications to medicine. Medical informatics ,NGMV, Normalized grey matter volume ,050105 experimental psychology ,SD, standard deviations ,CII, cognitive impairment index ,EDSS, Expanded Disability Status Scale ,WCST, Wisconsin Card Sorting Test ,03 medical and health sciences ,Atrophy ,medicine ,Humans ,0501 psychology and cognitive sciences ,Radiology, Nuclear Medicine and imaging ,WM, white matter ,lcsh:Neurology. Diseases of the nervous system ,Thalamu ,CI, cognitively impaired and preserved (CP) ,BRB-N, Brief Repeatable Battery of Neuropsychological Tests ,business.industry ,Multiple sclerosis ,FSL-FIRST, FMRIB Integrated Registration and Segmentation Tool ,eTIV, estimated total intracranial volume ,CAT12, Computational Anatomy Toolbox for Statistical Parametric Mapping 12 ,GM, grey matter ,medicine.disease ,Deep grey matter ,NWMV, Normalized white matter volume ,MS, Multiple Sclerosis ,GMV, grey matter volume ,IPS, information processing speed ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,Other subheadings::Other subheadings::/complications [Other subheadings] - Abstract
Highlights • Thalamus atrophy is associated with cognitive impairment in multiple sclerosis. • This was confirmed by automated and manual segmentations, but effect sizes varied. • The algorithms work in a multi-center setting. • Automated techniques exhibit proportional bias with respect to thalamus size. • Differences between vendors can affect the robustness of these associations., Background and rationale Thalamus atrophy has been linked to cognitive decline in multiple sclerosis (MS) using various segmentation methods. We investigated the consistency of the association between thalamus volume and cognition in MS for two common automated segmentation approaches, as well as fully manual outlining. Methods Standardized neuropsychological assessment and 3-Tesla 3D-T1-weighted brain MRI were collected (multi-center) from 57 MS patients and 17 healthy controls. Thalamus segmentations were generated manually and using five automated methods. Agreement between the algorithms and manual outlines was assessed with Bland-Altman plots; linear regression assessed the presence of proportional bias. The effect of segmentation method on the separation of cognitively impaired (CI) and preserved (CP) patients was investigated through Generalized Estimating Equations; associations with cognitive measures were investigated using linear mixed models, for each method and vendor. Results In smaller thalami, automated methods systematically overestimated volumes compared to manual segmentations [ρ=(-0.42)-(-0.76); p-values
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- 2021
20. Damage in the Thalamocortical Tracts is Associated With Subsequent Thalamus Atrophy in Early Multiple Sclerosis
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Weeda, Merlin M., Pruis, Ilanah J., Westerveld, Aimee S. R., Brouwer, Iman, Bellenberg, Barbara (Dr. rer. medic.), Barkhof, Frederik, Vrenken, Hugo, Lukas, Carsten (Prof. Dr. med.), Schneider, Ruth (Dr. med.), Pouwels, Petra J. W., Radiology and nuclear medicine, and Amsterdam Neuroscience - Neuroinfection & -inflammation
- Subjects
nervous system ,Neurology ,longitudinal study ,mean diffusivity ,ddc:610 ,early MS ,thalamocortical tracts ,multiple sclerosis ,thalamus atrophy ,white matter damage ,fractional anisotropy ,Original Research - Abstract
\(\bf Background:\) In early multiple sclerosis (MS), thalamus atrophy and decreased integrity of the thalamocortical white matter (WM) tracts have been observed. \(\bf Objective:\) To investigate the temporal association between thalamus volume and WM damage in the thalamocortical tract in subjects with early MS. \(\bf Methods:\) At two time points, 72 subjects with early MS underwent T1, FLAIR and diffusion tensor imaging. Thalamocortical tracts were identified with probabilistic tractography using left and right thalamus as seed regions. Regression analysis was performed to identify predictors of annual percentage change in both thalamus volumes and integrity of the connected tracts. \(\bf Results:\) Significant atrophy was seen in left and right thalamus (\(\it p\) < 0.001) over the follow-up period (13.7 \(\pm\) 4.8 months), whereas fractional anisotropy (FA) and mean diffusivity (MD) changes of the left and right thalamus tracts were not significant, although large inter-subject variability was seen. Annual percentage change in left thalamus volume was significantly predicted by baseline FA of the left thalamus tracts (\(\it F\)(1.71) = 4.284, (\(\it p\) = 0.042; while no such relation was found for the right thalamus. Annual percentage change in FA or MD of the thalamus tracts was not predicted by thalamus volume or any of the demographic parameters. \(\bf Conclusion:\) Over a short follow-up time, thalamus atrophy could be predicted by decreased integrity of the thalamic tracts, but changes in the integrity of the thalamic tracts could not be predicted by thalamus volume. This is the first study showing directionality in the association between thalamus atrophy and connected WM tract damage. These results need to be verified over longer follow-up periods.
- Published
- 2020
21. The sequence of structural, functional and cognitive changes in multiple sclerosis
- Author
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Dekker, Iris, primary, Schoonheim, Menno M., additional, Venkatraghavan, Vikram, additional, Eijlers, Anand J.C., additional, Brouwer, Iman, additional, Bron, Esther E., additional, Klein, Stefan, additional, Wattjes, Mike P., additional, Wink, Alle Meije, additional, Geurts, Jeroen J.G., additional, Uitdehaag, Bernard M.J., additional, Oxtoby, Neil P., additional, Alexander, Daniel C., additional, Vrenken, Hugo, additional, Killestein, Joep, additional, Barkhof, Frederik, additional, and Wottschel, Viktor, additional
- Published
- 2021
- Full Text
- View/download PDF
22. Novel imaging phantom for accurate and robust measurement of brain atrophy rates using clinical MRI
- Author
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Amiri, Houshang, primary, Brouwer, Iman, additional, Kuijer, Joost P.A., additional, de Munck, Jan C., additional, Barkhof, Frederik, additional, and Vrenken, Hugo, additional
- Published
- 2019
- Full Text
- View/download PDF
23. High reproducibility and robustness to lesions, but large software and scanner effects for mean upper cervical cord area (MUCCA) measurement in MS
- Author
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Vrenken, Hugo, primary, M. Weeda, Merlin, primary, D. Steenwijk, Martijn, primary, Amiri, Houshang, primary, Brouwer, Iman, primary, Killestein, Joep, primary, Dekker, Iris, primary, and Barkhof, Frederik, primary
- Published
- 2018
- Full Text
- View/download PDF
24. Haptic collision handling for simulation of transnasal surgery
- Author
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Neubauer, André, Brooks, Rupert, Brouwer, Iman, Debergue, Patricia, and Laroche, Denis
- Subjects
collision handling ,haptics ,virtual coupling ,ComputingMethodologies_COMPUTERGRAPHICS ,surgical simulation ,transnasal endoscopy - Abstract
Simulation of endoscopic navigation in the narrow nasal cavity poses important challenges to the computation of adequate and near-realistic collision response and haptic feedback because extensive multidirectional contact and massive tissue deformations are inevitable. We present a virtual coupling algorithm that provides stable collision response as well as intuitive and smooth haptic interaction in all phases of the simulation. In each iteration, continuous collision detection between the point shell representing the surface of the virtual patient anatomy and the endoscope, represented by a cylinder, is performed. This allows for rolling back the instrument movement to the point in time the first collision occurred. Subsequently, a relaxation process locally optimizes the position and orientation of the instrument. A novel method of applying contact forces to colliding tissues and thus triggering appropriate deformations improves the fluency of navigation. This paper describes the algorithm and presents experimental results.
- Published
- 2012
25. Performance Evaluation of Real-Time Soft Tissue Models for Surgical Simulation
- Author
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Mora, Vincent, Brouwer, Iman, and Laroche, Denis
- Abstract
Symposium on Computer Simulation in Medicine(CompMed), Boucherville, Quebec, May 16-18, 2007
- Published
- 2007
26. Surgical Scissors Extension Adds the 7th Axis of Force Feedback to the Freedom 6S
- Author
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Powers, Marilyn J., Sinclair, Ian P. W., Brouwer, Iman, and Laroche, Denis
- Abstract
The 15th Annual Medicine Meets Virtual Reality Conference, Long Beach, California, February 6-9, 2007
- Published
- 2007
27. Development and Evaluation of Algorithms for Accurate Force Rendering in Neurosurgery Simulation
- Author
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Mora, Vincent, Brouwer, Iman, Laroche, Denis, Sutherland, Garnette, and DiRaddo, Robert
- Abstract
The 15th Annual Medicine Meets Virtual Reality Conference, Long Beach, California, February 06-09, 2007
- Published
- 2007
28. Cost-performance trade-offs in haptic hardware design
- Author
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Brouwer, Iman
- Abstract
The objective of this research was to determine whether low performance haptic hardware leads to the same surgical task performance compared to more expensive hardware in a virtual reality surgical simulator for laparoscopy. VR surgical simulators are currently being introduced in leading teaching hospitals around the world. While they provide great potential for improvement over current laparoscopic skills training methods, a major barrier to large-scale acceptance is their high cost. Therefore this study is performed to determine whether a reduction in quality and therefore cost can be obtained without affecting surgical task performance. To perform user test at different levels of haptic quality, we developed software that can introduce friction, cogging, force saturation, inertia, and backlash into the haptic loop, simulating the characteristics of less expensive hardware on a high-end haptic interface. This software avoids the need for an expensive hardware redesign, while it allows varying the different parameters on a continuous scale, independent from each other, and within a realistic range. In a pilot study expert surgeons performed a clip application (2 participants) and a dissection task (3 participants) on commercial haptic hardware and VR laparoscopic software. Each surgeon performed the task(s) 3 times under 5 different settings while forces and kinematic data were recorded. Two settings were picked from the ones mentioned above; the other three consisted of the unaltered high fidelity setting, zero force feedback, and a combination of force saturation, cogging, friction, and inertia. We compared tissue-interaction forces, velocities, tool-tip path lengths, and completion times between the high fidelity setting and each of the other 7 settings. At a significance level of 0.05 a Friedman test showed that only the no force feedback condition was significantly different from the high fidelity condition in applied 95 percentile forces. In the clip application task both 50 percentile, and 95 percentile forces were significantly different in the no force feedback condition compared to high fidelity. None of the other settings showed significant differences in any of the performance measures. These preliminary results suggest that low performance components can be used in haptic hardware for laparoscopy without affecting task performance, potentially creating a significant cost reduction.
- Published
- 2004
- Full Text
- View/download PDF
29. Cell Wall Assembly and Intracellular Trafficking in Plant Cells Are Directly Affected by Changes in the Magnitude of Gravitational Acceleration
- Author
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Chebli, Youssef, primary, Pujol, Lauranne, additional, Shojaeifard, Anahid, additional, Brouwer, Iman, additional, van Loon, Jack J. W. A., additional, and Geitmann, Anja, additional
- Published
- 2013
- Full Text
- View/download PDF
30. Haptic collision handling for simulation of transnasal surgery
- Author
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Neubauer, André, primary, Brooks, Rupert, additional, Brouwer, Iman, additional, Debergue, Patricia, additional, and Laroche, Denis, additional
- Published
- 2012
- Full Text
- View/download PDF
31. Validation of a semi-automated method to quantify lesion volume changes in multiple sclerosis on 2D proton-density-weighted scans based on image subtraction
- Author
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Mattiesing, Rozemarijn M., Stel, Serena, Mangroe, Alysha S., Brouwer, Iman, Versteeg, Adriaan, van Schijndel, Ronald A., Uitdehaag, Bernard M.J., Barkhof, Frederik, Vrenken, Hugo, and Kuijer, Joost P.A.
- Abstract
The detection and quantification of changes in white matter lesions in the brain is important to monitor treatment effects in patients with multiple sclerosis (MS). Existing automatic tools predominantly require FLAIR images as input which are not always available, or only focus on new/enlarging activity. Therefore, we developed and validated a semi-automated method to quantify lesion volume changes based on 2D proton-density (PD)-weighted images and image subtraction. This semi-automated method provides insight in both “positive” activity (defined as new and enlarging lesions) and “negative” activity (disappearing and shrinking lesions).
- Published
- 2023
- Full Text
- View/download PDF
32. A viscoelastic soft tissue model for haptic surgical simulation
- Author
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Brouwer, Iman, primary, Mora, Vincent, additional, and Laroche, Denis, additional
- Published
- 2007
- Full Text
- View/download PDF
33. Haptic collision handling for simulation of transnasal surgery.
- Author
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Neubauer , André, Brooks, Rupert, Brouwer, Iman, Debergue, Patricia, and Laroche, Denis
- Subjects
OPERATIVE surgery ,INTRANASAL medication ,SIMULATION methods & models ,HAPTIC devices ,COLLISION detection (Computer animation) ,COMPUTER-generated imagery ,NASAL cavity - Abstract
ABSTRACT Simulation of endoscopic navigation in the narrow nasal cavity poses important challenges to the computation of adequate and near-realistic collision response and haptic feedback because extensive multidirectional contact and massive tissue deformations are inevitable. We present a virtual coupling algorithm that provides stable collision response as well as intuitive and smooth haptic interaction in all phases of the simulation. In each iteration, continuous collision detection between the point shell representing the surface of the virtual patient anatomy and the endoscope, represented by a cylinder, is performed. This allows for rolling back the instrument movement to the point in time the first collision occurred. Subsequently, a relaxation process locally optimizes the position and orientation of the instrument. A novel method of applying contact forces to colliding tissues and thus triggering appropriate deformations improves the fluency of navigation. This paper describes the algorithm and presents experimental results. © Her Majesty the Queen in Right of Canada 2012. Reproduced with the permission of the Minister of Medical Devices, National Research Council Canada. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
34. Surgical Scissors Extension adds the 7th axis of Force Feedback to the Freedom 6S.
- Author
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Westwood, James D., Haluck, Randy S., Hoffman, Helene M., Mogel, Greg T., Phillips, Roger, Robb, Richard A., Vosburgh, Kirby G., Powers, Marilyn J., Sinclair, Ian P.W., Brouwer, Iman, and Laroche, Denis
- Abstract
A virtual reality surgical simulator ideally allows seamless transition between the real and virtual world. In that respect, all of a surgeon's motions and tools must be simulated. Until now researchers have been limited to using a pen-like tool in six degrees-of-freedom. This paper presents the addition of haptically enabled scissors to the end effector of a 6-DOF haptic device, the Freedom 6S. The scissors are capable of pinching a maximum torque of 460 mN·m with low inertia and low back-drive friction. The device is a balanced design so that the user feels like they are holding no more than actual scissors, although with some added inertia on the load end. The system is interchangeable between the 6-DOF and 7-DOF configurations to allow switching tools quickly. [ABSTRACT FROM AUTHOR]
- Published
- 2007
35. Cross-sectional robustness of 6 freely available software packages for brain volume measurements in multiple sclerosis
- Author
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van Nederpelt, David, primary, Amiri, Houshang, additional, Mariyampillai, Amanda, additional, Brouwer, Iman, additional, Noteboom, Samantha, additional, Barkhof, Frederik, additional, Kuijer, Joost, additional, and Vrenken, Hugo, additional
- Full Text
- View/download PDF
36. Disease progression in the first 5 years of treatment in multiple sclerosis: Predictive value of early brain and lesion volume changes.
- Author
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Mattiesing RM, Kramer E, Strijbis EM, Brouwer I, van Schijndel RA, Gentile G, Battaglini M, De Stefano N, Uitdehaag BM, Barkhof F, Vrenken H, and Schoonheim MM
- Subjects
- Humans, Brain diagnostic imaging, Brain pathology, Interferon beta-1a, Disease Progression, Atrophy pathology, Magnetic Resonance Imaging methods, Multiple Sclerosis diagnostic imaging, Multiple Sclerosis drug therapy, Multiple Sclerosis pathology
- Abstract
Background: Whether the degree of inflammation (and its resolution) and neurodegeneration after treatment initiation predicts disease progression in multiple sclerosis (MS) remains unclear., Objectives: To assess the predictive value of magnetic resonance imaging (MRI)-derived brain and lesion volume (LV) changes in years 1 and 2 of treatment for disease progression., Methods: Patients receiving early interferon beta-1a treatment in REFLEX/REFLEXION ( N = 262) were included. Predictive regression models included new/enlarging LV (positive activity), disappearing/shrinking LV (negative activity), and global/central atrophy during years 1 and 2., Results: Faster global atrophy and/or pseudo-atrophy and positive lesion activity in years 1 and 2 related to an increased probability and faster conversion to clinically definite multiple sclerosis (CDMS). Negative lesion activity in year 1 and slower central atrophy in year 2 were predictive of confirmed disability progression (9-Hole Peg Test). Positive lesion activity in year 2 was predictive of faster global atrophy, while positive lesion activity in years 1 and 2 was predictive of faster central atrophy., Conclusions: A higher degree of global atrophy and/or pseudo-atrophy in year 1 was predictive of CDMS. Positive lesion activity in any year was related to CDMS and neurodegeneration. Disability was related to negative lesion activity in year 1 and slower central atrophy in year 2., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: R.M.M. has received research support from Merck. I.B. has received research support from Merck, Novartis, Teva, and the Dutch MS Research Foundation. N.D.S. is a consultant for Biogen, Merck, Novartis, Roche, Sanofi-Genzyme, and Teva; has grants or grants pending from FISM and Novartis; is on the speakers’ bureaus of Biogen, Merck, Novartis, Roche, Sanofi-Genzyme, and Teva; and has received travel funds from Merck, Novartis, Roche, Sanofi-Genzyme, and Teva. B.M.J.U. reports research support and/or consultancy fees from Biogen, Genzyme, Merck, Novartis, Roche, Teva, and Immunic Therapeutics. F.B. is a steering committee or Data Safety Monitoring Board member for Biogen, Merck, ATRI/ACTC, and Prothena; is a consultant for Roche, Celltrion, Rewind Therapeutics, Merck, IXICO, Jansen, and Combinostics; is a co-founder and shareholder of Queen Square Analytics Ltd.; and has research agreements with Merck, Biogen, GE Healthcare, and Roche. H.V. has received research support from Merck, Novartis, Pfizer, and Teva; consulting fees from Merck, and speaker honoraria from Novartis; all funds were paid to his institution. M.M.S. serves on the editorial board of Neurology and Frontiers in Neurology; receives research support from the Dutch MS Research Foundation, Eurostars-EUREKA, ARSEP, Amsterdam Neuroscience, MAGNIMS, and ZonMW (Vidi grant, project number 09150172010056); and has served as a consultant for or received research support from Atara Biotherapeutics, Biogen, Celgene/Bristol Meyers Squibb, EIP, Sanofi, MedDay, and Merck. E.K., E.M.M.S., R.A.v.S., G.G., and M.B. report no disclosures.
- Published
- 2024
- Full Text
- View/download PDF
37. Reduced accuracy of MRI deep grey matter segmentation in multiple sclerosis: an evaluation of four automated methods against manual reference segmentations in a multi-center cohort.
- Author
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de Sitter A, Verhoeven T, Burggraaff J, Liu Y, Simoes J, Ruggieri S, Palotai M, Brouwer I, Versteeg A, Wottschel V, Ropele S, Rocca MA, Gasperini C, Gallo A, Yiannakas MC, Rovira A, Enzinger C, Filippi M, De Stefano N, Kappos L, Frederiksen JL, Uitdehaag BMJ, Barkhof F, Guttmann CRG, and Vrenken H
- Subjects
- Atrophy pathology, Brain diagnostic imaging, Brain pathology, Gray Matter diagnostic imaging, Gray Matter pathology, Humans, Magnetic Resonance Imaging, Multiple Sclerosis diagnostic imaging, Multiple Sclerosis pathology
- Abstract
Background: Deep grey matter (DGM) atrophy in multiple sclerosis (MS) and its relation to cognitive and clinical decline requires accurate measurements. MS pathology may deteriorate the performance of automated segmentation methods. Accuracy of DGM segmentation methods is compared between MS and controls, and the relation of performance with lesions and atrophy is studied., Methods: On images of 21 MS subjects and 11 controls, three raters manually outlined caudate nucleus, putamen and thalamus; outlines were combined by majority voting. FSL-FIRST, FreeSurfer, Geodesic Information Flow and volBrain were evaluated. Performance was evaluated volumetrically (intra-class correlation coefficient (ICC)) and spatially (Dice similarity coefficient (DSC)). Spearman's correlations of DSC with global and local lesion volume, structure of interest volume (ROIV), and normalized brain volume (NBV) were assessed., Results: ICC with manual volumes was mostly good and spatial agreement was high. MS exhibited significantly lower DSC than controls for thalamus and putamen. For some combinations of structure and method, DSC correlated negatively with lesion volume or positively with NBV or ROIV. Lesion-filling did not substantially change segmentations., Conclusions: Automated methods have impaired performance in patients. Performance generally deteriorated with higher lesion volume and lower NBV and ROIV, suggesting that these may contribute to the impaired performance.
- Published
- 2020
- Full Text
- View/download PDF
38. Surgical scissors extension adds the 7th axis of force feedback to the Freedom 6S.
- Author
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Powers MJ, Sinclair IP, Brouwer I, and Laroche D
- Subjects
- Canada, Computer Simulation, Feedback, General Surgery instrumentation, Touch, User-Computer Interface
- Abstract
A virtual reality surgical simulator ideally allows seamless transition between the real and virtual world. In that respect, all of a surgeon's motions and tools must be simulated. Until now researchers have been limited to using a pen-like tool in six degrees-of-freedom. This paper presents the addition of haptically enabled scissors to the end effector of a 6-DOF haptic device, the Freedom 6S. The scissors are capable of pinching a maximum torque of 460 mN.m with low inertia and low back-drive friction. The device is a balanced design so that the user feels like they are holding no more than actual scissors, although with some added inertia on the load end. The system is interchangeable between the 6-DOF and 7-DOF configurations to allow switching tools quickly.
- Published
- 2007
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