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1. Evidence of Zika Virus Reinfection by Genome Diversity and Antibody Response Analysis, Brazil

Author

Castilho, Marcia da Costa, de Filippis, Ana Maria Bispo, Machado, Lais Ceschini, de Lima Calvanti, Thaise Yasmine Vasconcelos, Lima, Morganna Costa, Fonseca, Vagner, Giovanetti, Marta, Docena, Cassia, Neto, Armando Menezes, Botto-Menezes, Camila Helena Aguiar, Kara, Edna Oliveira, de La Barrera, Rafael, Modjarrad, Kayvon, Giozza, Silvana Pereira, Pereira, Gerson Fernando, Alcantara, Luiz Carlos Junior, Broutet, Nathalie Jeanne Nicole, Calvet, Guilherme Amaral, Wallau, Gabriel Luz, and Franca, Rafael Freitas Oliveira

Subjects
Genomics -- Analysis -- Health aspects, Viral antibodies -- Health aspects -- Analysis, Genomes -- Analysis -- Health aspects, Phylogeny -- Health aspects -- Analysis, Antibodies -- Health aspects -- Analysis, Health, World Health Organization
Abstract

Zika virus (ZIKV) is an arthropodborne virus belonging to the Flaviviridae family. Virions are enveloped for a single-stranded positive-sense RNA genome of [approximately equal to]10.8-kb (1). ZIKV is transmitted through [...]

Published
2024
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2. Adverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection: an individual participant data meta-analysis

Author

Smith, Emily R, Oakley, Erin, Grandner, Gargi Wable, Ferguson, Kacey, Farooq, Fouzia, Afshar, Yalda, Ahlberg, Mia, Ahmadzia, Homa, Akelo, Victor, Aldrovandi, Grace, Barr, Beth A Tippett, Bevilacqua, Elisa, Brandt, Justin S, Broutet, Nathalie, Buhigas, Irene Fernández, Carrillo, Jorge, Clifton, Rebecca, Conry, Jeanne, Cosmi, Erich, Crispi, Fatima, Crovetto, Francesca, Delgado-López, Camille, Divakar, Hema, Driscoll, Amanda J, Favre, Guillaume, Flaherman, Valerie J, Gale, Chris, Gil, Maria M, Gottlieb, Sami L, Gratacós, Eduard, Hernandez, Olivia, Jones, Stephanie, Kalafat, Erkan, Khagayi, Sammy, Knight, Marian, Kotloff, Karen, Lanzone, Antonio, Le Doare, Kirsty, Lees, Christoph, Litman, Ethan, Lokken, Erica M, Longo, Valentina Laurita, Madhi, Shabir A, Magee, Laura A, Martinez-Portilla, Raigam Jafet, McClure, Elizabeth M, Metz, Tori D, Miller, Emily S, Money, Deborah, Moungmaithong, Sakita, Mullins, Edward, Nachega, Jean B, Nunes, Marta C, Onyango, Dickens, Panchaud, Alice, Poon, Liona C, Raiten, Daniel, Regan, Lesley, Rukundo, Gordon, Sahota, Daljit, Sakowicz, Allie, Sanin-Blair, Jose, Söderling, Jonas, Stephansson, Olof, Temmerman, Marleen, Thorson, Anna, Tolosa, Jorge E, Townson, Julia, Valencia-Prado, Miguel, Visentin, Silvia, von Dadelszen, Peter, Waldorf, Kristina Adams, Whitehead, Clare, Yassa, Murat, Tielsch, Jim M, Langenegger, Eduard, Sam-Agudu, Nadia A, Gachuno, Onesmus W, Sekikubo, Musa, Mukwege, Denis M, Omore, Richard, Ouma, Gregory, Onyango, Clayton, Otieno, Kephas, Were, Zacchaeus Abaja, Were, Joyce, İlter, Pinar Birol, Mboizi, Robert, Hookham, Lauren, Meli, Federica, Bonanni, Giulia, Romanzi, Federica, Torcia, Eleonora, di Ilio, Chiara, Ananth, Cande V, Hill, Jennifer, Reddy, Ajay, Patrick, Haylea Sweat, Baba, Vuyelwa, and Adam, Mary

Subjects
Biodefense, Pneumonia, Lung, Infant Mortality, Vaccine Related, Emerging Infectious Diseases, Clinical Trials and Supportive Activities, Clinical Research, Pediatric, Perinatal Period - Conditions Originating in Perinatal Period, Preterm, Low Birth Weight and Health of the Newborn, Infectious Diseases, Prevention, Pneumonia & Influenza, Infection, Reproductive health and childbirth, Good Health and Well Being, Infant, Newborn, Pregnancy, Female, Humans, Pregnant Women, Prospective Studies, COVID-19, SARS-CoV-2, Maternal health, Epidemiology, Perinatal COVID PMA Study Collaborators
Abstract

IntroductionDespite a growing body of research on the risks of SARS-CoV-2 infection during pregnancy, there is continued controversy given heterogeneity in the quality and design of published studies.MethodsWe screened ongoing studies in our sequential, prospective meta-analysis. We pooled individual participant data to estimate the absolute and relative risk (RR) of adverse outcomes among pregnant women with SARS-CoV-2 infection, compared with confirmed negative pregnancies. We evaluated the risk of bias using a modified Newcastle-Ottawa Scale.ResultsWe screened 137 studies and included 12 studies in 12 countries involving 13 136 pregnant women.Pregnant women with SARS-CoV-2 infection-as compared with uninfected pregnant women-were at significantly increased risk of maternal mortality (10 studies; n=1490; RR 7.68, 95% CI 1.70 to 34.61); admission to intensive care unit (8 studies; n=6660; RR 3.81, 95% CI 2.03 to 7.17); receiving mechanical ventilation (7 studies; n=4887; RR 15.23, 95% CI 4.32 to 53.71); receiving any critical care (7 studies; n=4735; RR 5.48, 95% CI 2.57 to 11.72); and being diagnosed with pneumonia (6 studies; n=4573; RR 23.46, 95% CI 3.03 to 181.39) and thromboembolic disease (8 studies; n=5146; RR 5.50, 95% CI 1.12 to 27.12).Neonates born to women with SARS-CoV-2 infection were more likely to be admitted to a neonatal care unit after birth (7 studies; n=7637; RR 1.86, 95% CI 1.12 to 3.08); be born preterm (7 studies; n=6233; RR 1.71, 95% CI 1.28 to 2.29) or moderately preterm (7 studies; n=6071; RR 2.92, 95% CI 1.88 to 4.54); and to be born low birth weight (12 studies; n=11 930; RR 1.19, 95% CI 1.02 to 1.40). Infection was not linked to stillbirth. Studies were generally at low or moderate risk of bias.ConclusionsThis analysis indicates that SARS-CoV-2 infection at any time during pregnancy increases the risk of maternal death, severe maternal morbidities and neonatal morbidity, but not stillbirth or intrauterine growth restriction. As more data become available, we will update these findings per the published protocol.

Published
2023

3. Benefits, harms and cost-effectiveness of cervical screening, triage and treatment strategies for women in the general population

Author

Simms, Kate T., Keane, Adam, Nguyen, Diep Thi Ngoc, Caruana, Michael, Hall, Michaela T., Lui, Gigi, Gauvreau, Cindy, Demke, Owen, Arbyn, Marc, Basu, Partha, Wentzensen, Nicolas, Lauby-Secretan, Beatrice, Ilbawi, Andre, Hutubessy, Raymond, Almonte, Maribel, De Sanjosé, Silvia, Kelly, Helen, Dalal, Shona, Eckert, Linda O., Santesso, Nancy, Broutet, Nathalie, and Canfell, Karen

Published
2023
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4. Benefits and harms of cervical screening, triage and treatment strategies in women living with HIV

Author

Hall, Michaela T., Simms, Kate T., Murray, John M., Keane, Adam, Nguyen, Diep T. N., Caruana, Michael, Lui, Gigi, Kelly, Helen, Eckert, Linda O., Santesso, Nancy, de Sanjose, Silvia, Swai, Edwin E., Rangaraj, Ajay, Owiredu, Morkor Newman, Gauvreau, Cindy, Demke, Owen, Basu, Partha, Arbyn, Marc, Dalal, Shona, Broutet, Nathalie, and Canfell, Karen

Published
2023
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5. WHO global research priorities for sexually transmitted infections

Author

Gottlieb, Sami L, Spielman, Erica, Abu-Raddad, Laith, Aderoba, Adeniyi Kolade, Bachmann, Laura H, Blondeel, Karel, Chen, Xiang-Sheng, Crucitti, Tania, Camacho, Gabriela Garcia, Godbole, Sheela, de Leon, Rodolfo Gómez Ponce, Gupta, Somesh, Hermez, Joumana, Ishikawa, Naoko, Klausner, Jeffrey D, Kurbonov, Firdavs, Maatouk, Ismael, Mandil, Ahmed, Mello, Maeve B, Miranda, Angelica Espinosa, Mosha, Fausta Shakiwa, Okeibunor, Joseph Chukwudi, Ong, Jason J, Peters, Remco P H, Pérez, Freddy, Seguy, Nicole, Seib, Kate L, Sharma, Mukta, Sladden, Tim, Van Der Pol, Barbara, White, Peter J, Wi, Teodora, and Broutet, Nathalie

Published
2024
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6. Detection and persistence of Zika virus in body fluids and associated factors: a prospective cohort study

Author

Calvet, Guilherme Amaral, Kara, Edna Oliveira, Bôtto-Menezes, Camila Helena Aguiar, da Costa Castilho, Marcia, de Oliveira Franca, Rafael Freitas, Habib, Ndema, Neto, Armando Menezes, Pereira, Gerson Fernando Mendes, Giozza, Silvana Pereira, Bermúdez, Ximena Pamela Díaz, Fernandes, Tatiana Jorge, Modjarrad, Kayvon, Brasil, Patrícia, Broutet, Nathalie Jeanne Nicole, and de Filippis, Ana Maria Bispo

Published
2023
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7. Performance of cervical cytology and HPV testing for primary cervical cancer screening in Latin America: an analysis within the ESTAMPA study

Author

Rol, Mary Luz, Lucas, Eric, Hernández, María de la Luz, Sánchez, Gloria Inés, Murillo, Raul, Jerónimo, Jose, Ferreccio, Catterina, Rodríguez, María Isabel, Cabrera, Yessy, Salgado, Brenda, Colucci, María Celeste, Saino, Maria Agustina, Rodríguez de la Peña, Margarita, Fernández, Daniel Llanos, García, Laura, Caserta, Benedicta, Doimi, Franco, Lazcano-Ponce, Eduardo, Ramírez, Arianis Tatiana, Valls, Joan, Baena, Armando, Rojas, Freddy David, Ramírez, Katherine, Álvarez, Rodrigo, Cristaldo, Carmen, Henríquez, Odessa, Moreno, Adrián, Reynaga, Daysi Colque, Palma, Hans González, Robinson, Isabel, Hernández, Diana Carolina, Bardales, Rosa, Cardinal, Lucia, Salgado, Yuly, Martínez, Sandra, González, Emmanuel, Guillén, Diego, Fleider, Laura, Tatti, Silvio, Villagra, Verónica, Venegas, Gino, Cruz-Valdez, Aurelio, Valencia, Marleny, Rodríguez, Guillermo, Terán, Carolina, Picconi, María Alejandra, Ferrera, Annabelle, Kasamatsu, Elena, Mendoza, Laura, Calderon, Alejandro, Luciani, Silvana, Broutet, Nathalie, Darragh, Teresa, Almonte, Maribel, and Herrero, Rolando

Published
2023
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9. Cervical cancer

Author

Banatvala, Nick, primary, Bhatla, Neerja, additional, Arrossi, Silvina, additional, and Broutet, Nathalie, additional

Published
2023
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10. Multicentric study of cervical cancer screening with human papillomavirus testing and assessment of triage methods in Latin America: the ESTAMPA screening study protocol.

Author

Almonte, Maribel, Murillo, Raúl, Sánchez, Gloria Inés, González, Paula, Ferrera, Annabelle, Picconi, María Alejandra, Wiesner, Carolina, Cruz-Valdez, Aurelio, Lazcano-Ponce, Eduardo, Jerónimo, Jose, Ferreccio, Catterina, Kasamatsu, Elena, Mendoza, Laura, Rodríguez, Guillermo, Calderón, Alejandro, Venegas, Gino, Villagra, Verónica, Tatti, Silvio, Fleider, Laura, Terán, Carolina, Baena, Armando, Hernández, María de la Luz, Rol, Mary Luz, Lucas, Eric, Barbier, Sylvaine, Ramírez, Arianis Tatiana, Arrossi, Silvina, Rodríguez, María Isabel, González, Emmanuel, Celis, Marcela, Martínez, Sandra, Salgado, Yuly, Ortega, Marina, Beracochea, Andrea Verónica, Pérez, Natalia, Rodríguez de la Peña, Margarita, Ramón, María, Hernández-Nevarez, Pilar, Arboleda-Naranjo, Margarita, Cabrera, Yessy, Salgado, Brenda, García, Laura, Retana, Marco Antonio, Colucci, María Celeste, Arias-Stella, Javier, Bellido-Fuentes, Yenny, Bobadilla, María Liz, Olmedo, Gladys, Brito-García, Ivone, Méndez-Herrera, Armando, Cardinal, Lucía, Flores, Betsy, Peñaranda, Jhacquelin, Martínez-Better, Josefina, Soilán, Ana, Figueroa, Jacqueline, Caserta, Benedicta, Sosa, Carlos, Moreno, Adrián, Mural, Juan, Doimi, Franco, Giménez, Diana, Rodríguez, Hernando, Lora, Oscar, Luciani, Silvana, Broutet, Nathalie, Darragh, Teresa, and Herrero, Rolando

Subjects
Humans, Papillomavirus Infections, Cervical Intraepithelial Neoplasia, Colposcopy, Adult, Middle Aged, Triage, Latin America, Uterine Cervical Neoplasms, Female, Alphapapillomavirus, Early Detection of Cancer, colposcopy, gynaecological oncology, molecular diagnostics, preventive medicine, public health, risk management, Clinical Sciences, Public Health and Health Services, Other Medical and Health Sciences
Abstract

IntroductionHuman papillomavirus (HPV) testing is replacing cytology in primary screening. Its limited specificity demands using a second (triage) test to better identify women at high-risk of cervical disease. Cytology represents the immediate triage but its low sensitivity might hamper HPV testing sensitivity, particularly in low-income and middle-income countries (LMICs), where cytology performance has been suboptimal. The ESTAMPA (EStudio multicéntrico de TAMizaje y triaje de cáncer de cuello uterino con pruebas del virus del PApiloma humano; Spanish acronym) study will: (1) evaluate the performance of different triage techniques to detect cervical precancer and (2) inform on how to implement HPV-based screening programmes in LMIC.Methods and analysisWomen aged 30-64 years are screened with HPV testing and Pap across 12 study centres in Latin America. Screened positives have colposcopy with biopsy and treatment of lesions. Women with no evident disease are recalled 18 months later for another HPV test; those HPV-positive undergo colposcopy with biopsy and treatment as needed. Biological specimens are collected in different visits for triage testing, which is not used for clinical management. The study outcome is histological high-grade squamous intraepithelial or worse lesions (HSIL+) under the lower anogenital squamous terminology. About 50 000 women will be screened and 500 HSIL+ cases detected (at initial and 18 months screening). Performance measures (sensitivity, specificity and predictive values) of triage techniques to detect HSIL+ will be estimated and compared with adjustment by age and study centre.Ethics and disseminationThe study protocol has been approved by the Ethics Committee of the International Agency for Research on Cancer (IARC), of the Pan American Health Organisation (PAHO) and by those in each participating centre. A Data and Safety Monitoring Board (DSMB) has been established to monitor progress of the study, assure participant safety, advice on scientific conduct and analysis and suggest protocol improvements. Study findings will be published in peer-reviewed journals and presented at scientific meetings.Trial registration numberNCT01881659.

Published
2020

11. Performance of standardised colposcopy to detect cervical precancer and cancer for triage of women testing positive for human papillomavirus: results from the ESTAMPA multicentric screening study

Author

Valls, Joan, Baena, Armando, Venegas, Gino, Celis, Marcela, González, Mauricio, Sosa, Carlos, Santin, Jorge Luis, Ortega, Marina, Soilán, Ana, Turcios, Elmer, Figueroa, Jacqueline, Rodríguez de la Peña, Margarita, Figueredo, Alicia, Beracochea, Andrea Verónica, Pérez, Natalia, Martínez-Better, Josefina, Lora, Oscar, Jiménez, Julio Yamil, Giménez, Diana, Fleider, Laura, Salgado, Yuly, Martínez, Sandra, Bellido-Fuentes, Yenny, Flores, Bettsy, Tatti, Silvio, Villagra, Verónica, Cruz-Valdez, Aurelio, Terán, Carolina, Sánchez, Gloria Inés, Rodríguez, Guillermo, Picconi, Maria Alejandra, Ferrera, Annabelle, Mendoza, Laura, Calderón, Alejandro, Murillo, Raul, Wiesner, Carolina, Broutet, Nathalie, Luciani, Silvana, Pérez, Carlos, Darragh, Teresa M, Jerónimo, José, Herrero, Rolando, and Almonte, Maribel

Published
2023
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16. Myopericarditis associated with acute Zika virus infection: a case report

Author

Bôtto-Menezes, Camila Helena Aguiar, Safe, Izabella Picinin, da Cunha Ferreira, Ana Cláudia, do Nascimento Couceiro, Katia, Neto, Armando Menezes, Franca, Rafael Freitas Oliveira, Calvet, Guilherme Amaral, de Filippis, Ana Maria Bispo, Kara, Edna Oliveira, da Costa Castilho, Marcia, Bastos, Michele Souza, de Brito, Carlos Alexandre Antunes, Modjarrad, Kayvon, Broutet, Nathalie Jeanne Nicole, Brasil, Patrícia, Hajjar, Ludhmila Abrahão, and de Lacerda, Marcus Vinícius Guimarães

Published
2022
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17. Implementation research to accelerate scale-up of national screen and treat strategies towards the elimination of cervical cancer

Author

Broutet, Nathalie, Jeronimo, Jose, Kumar, Somesh, Almonte, Maribel, Murillo, Raul, Huy, Nguyen Vu Quoc, Denny, Lynette, Kapambwe, Sharon, Bhatla, Neerja, Sebitloane, Motshedisi, Zhao, Fanghui, Gravitt, Patti, Adsul, Prajakta, Rangaraj, Ajay, Dalal, Shona, Newman, Morkor, Chowdhury, Raveena, Church, Kathryn, Nakisige, Carol, Diop, Mamadou, Parham, Groesbeck, Thomson, Kerry A., Basu, Partha, and Steyn, Petrus

Published
2022
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18. Treatment of COVID-19 in pregnant women: A systematic review and meta-analysis

Author

Chatterjee, Shaunak, Gae, Andrea, Stallings, Elena, Yap, Magnus, Sheikh, Jameela, Lawson, Heidi, Coomar, Dyuti, Dixit, Anushka, Zhou, Dengyi, Balaji, Rishab, Littmoden, Megan, King, Yasmin, Debenham, Luke, Clavé Llavall, Anna, Ansari, Kehkashan, Sandhu, Gurimaan, Banjoko, Adeolu, Fraser, Helen, Rajah, Tanisha, Ramkumar, Anoushka, Khashaba, Alya, Attarde, Shruit, Walker, Kate, Thornton, Jim, van Wely, Madelon, van Leeuwen, Elizabeth, Kostova, Elena, Khalil, Asma, Tiberi, Simon, Broutet, Nathalie, Rahn Kim, Caron, Thorson, Anna, Oladapo, Olufemi T., Zamora, Javier, Mofenson, Lynne, Giesbers, Steven, Goh, Edwina, Kew, Tania, Allotey, John, Brizuela, Vanessa, Kara, Edna, Kunst, Heinke, Bonet, Mercedes, and Thangaratinam, Shakila

Published
2021
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19. Evidence of Zika Virus Reinfection by Genome Diversity and Antibody Response Analysis, Brazil

Author

da Costa Castilho, Marcia, primary, de Filippis, Ana Maria Bispo, additional, Machado, Lais Ceschini, additional, de Lima Calvanti, Thaise Yasmine Vasconcelos, additional, Lima, Morganna Costa, additional, Fonseca, Vagner, additional, Giovanetti, Marta, additional, Docena, Cassia, additional, Neto, Armando Menezes, additional, Bôtto-Menezes, Camila Helena Aguiar, additional, Kara, Edna Oliveira, additional, de La Barrera, Rafael, additional, Modjarrad, Kayvon, additional, Giozza, Silvana Pereira, additional, Pereira, Gerson Fernando, additional, Alcantara, Luiz Carlos Junior, additional, Broutet, Nathalie Jeanne Nicole, additional, Calvet, Guilherme Amaral, additional, Wallau, Gabriel Luz, additional, and Franca, Rafael Freitas Oliveira, additional

Published
2024
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21. Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy : systematic review and meta-analysis

Author

PregCOV-19 Living Systematic Review Consortium, Allotey, John, Stallings, Elena, Bonet, Mercedes, Yap, Magnus, Chatterjee, Shaunak, Kew, Tania, Debenham, Luke, Llavall, Anna Clavé, Dixit, Anushka, Zhou, Dengyi, Balaj, Rishab, Lee, Siang Ing, Qiu, Xiu, Yuan, Mingyang, Coomar, Dyuti, Sheikh, Jameela, Lawson, Heidi, Ansari, Kehkashan, van Wely, Madelon, van Leeuwen, Elizabeth, Kostova, Elena, Kunst, Heinke, Khalil, Asma, Tiberi, Simon, Brizuela, Vanessa, Broutet, Nathalie, Kara, Edna, Kim, Caron Rahn, Thorson, Anna, Escuriet, Ramón, Oladapo, Olufemi T, Mofenson, Lynne, Zamora, Javier, and Thangaratinam, Shakila

Published
2020

24. Cervical Cancer Screening and Treatment Algorithms Using Human Papillomavirus Testing--Lessons Learnt from a South African Pilot Randomized Controlled Trial.

Author

Sebitloane, Hannah M., Forestier, Mathilde, Ginindza, Themba G., Dhlomo, Wendy, Moodley-Govender, Eshia, Darragh, Teresa M., Baena, Armando, Herrero, Rolando, Almonte, Maribel, Broutet, Nathalie, and De Vuyst, Hugo

Abstract

Background: To report quantitative and qualitative results on cervical cancer human papillomavirus (HPV)-based screening and treatment algorithms, with/out triage with visual inspection after acetic acid (VIA), followed by ablative treatment (AT). Methods: Women 30 to 54 years old from Durban, South Africa were recruited, regardless of human immunodeficiency virus (HIV) status, randomized into one of two study arms and screened for HPV. VIA triage arm: HPV-positive women were triaged using VIA, biopsied and received AT if VIA positive and eligible; no triage arm: eligible HPV-positive women received AT. Women ineligible for AT were referred to colposcopy. Women were asked about side effects immediately and 1 week after AT. Retention to screening and treatment algorithms was compared between arms. Results: A total of 350 women [275 HIV-uninfected and 75 women living with HIV, (WLWH)] were allocated to receive HPV testing with VIA triage (n = 175) or no triage (n = 175). HPV prevalence was 28% [95% confidence interval (CI) = 23-33]; WLWH: 52% (95% CI = 40-64) versus HIV-uninfected: 21% (95% CI = 17-27; P < 0.05). Among women who underwent VIA triage with histologic diagnosis, 3/17 were VIA negative with cervical intraepithelial neoplasia (CIN)2+; 14/18 were VIA positive with

Published
2024
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25. Cervical Cancer Screening and Treatment algorithms using Human Papillomavirus testing – lessons learnt from a South African pilot randomized controlled trial

Author

Sebitloane, Hannah M., primary, Forestier, Mathilde, additional, Ginindza, Themba G., additional, Dhlomo, Wendy, additional, Moodley-Govender, Eshia, additional, Darragh, Teresa M., additional, Baena, Armando, additional, Herrero, Rolando, additional, Almonte, Maribel, additional, Broutet, Nathalie, additional, and De Vuyst, Hugo, additional

Published
2023
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26. Performance of cervical cytology and HPV testing for primary cervical cancer screening in Latin America: an analysis within the ESTAMPA study

Author

Ramírez, Arianis Tatiana, primary, Valls, Joan, additional, Baena, Armando, additional, Rojas, Freddy David, additional, Ramírez, Katherine, additional, Álvarez, Rodrigo, additional, Cristaldo, Carmen, additional, Henríquez, Odessa, additional, Moreno, Adrián, additional, Reynaga, Daysi Colque, additional, Palma, Hans González, additional, Robinson, Isabel, additional, Hernández, Diana Carolina, additional, Bardales, Rosa, additional, Cardinal, Lucia, additional, Salgado, Yuly, additional, Martínez, Sandra, additional, González, Emmanuel, additional, Guillén, Diego, additional, Fleider, Laura, additional, Tatti, Silvio, additional, Villagra, Verónica, additional, Venegas, Gino, additional, Cruz-Valdez, Aurelio, additional, Valencia, Marleny, additional, Rodríguez, Guillermo, additional, Terán, Carolina, additional, Picconi, María Alejandra, additional, Ferrera, Annabelle, additional, Kasamatsu, Elena, additional, Mendoza, Laura, additional, Calderon, Alejandro, additional, Luciani, Silvana, additional, Broutet, Nathalie, additional, Darragh, Teresa, additional, Almonte, Maribel, additional, Herrero, Rolando, additional, Rol, Mary Luz, additional, Lucas, Eric, additional, Hernández, María de la Luz, additional, Sánchez, Gloria Inés, additional, Murillo, Raul, additional, Jerónimo, Jose, additional, Ferreccio, Catterina, additional, Rodríguez, María Isabel, additional, Cabrera, Yessy, additional, Salgado, Brenda, additional, Colucci, María Celeste, additional, Saino, Maria Agustina, additional, Rodríguez de la Peña, Margarita, additional, Fernández, Daniel Llanos, additional, García, Laura, additional, Caserta, Benedicta, additional, Doimi, Franco, additional, and Lazcano-Ponce, Eduardo, additional

Published
2023
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31. The cost and cost-effectiveness of scaling up screening and treatment of syphilis in pregnancy: a model.

Author

Jiwani, Aliya, Gomez, Gabriela, Hawkes, Sarah, Chesson, Harrell, Broutet, Nathalie, Kamb, Mary, Newman, Lori, and Kahn, James

Subjects
Cost of Illness, Cost-Benefit Analysis, Female, Humans, Infectious Disease Transmission, Vertical, Mass Screening, Pregnancy, Pregnancy Complications, Infectious, Prenatal Care, Quality-Adjusted Life Years, Sensitivity and Specificity, Syphilis, Congenital
Abstract

BACKGROUND: Syphilis in pregnancy imposes a significant global health and economic burden. More than half of cases result in serious adverse events, including infant mortality and infection. The annual global burden from mother-to-child transmission (MTCT) of syphilis is estimated at 3.6 million disability-adjusted life years (DALYs) and $309 million in medical costs. Syphilis screening and treatment is simple, effective, and affordable, yet, worldwide, most pregnant women do not receive these services. We assessed cost-effectiveness of scaling-up syphilis screening and treatment in existing antenatal care (ANC) programs in various programmatic, epidemiologic, and economic contexts. METHODS AND FINDINGS: We modeled the cost, health impact, and cost-effectiveness of expanded syphilis screening and treatment in ANC, compared to current services, for 1,000,000 pregnancies per year over four years. We defined eight generic country scenarios by systematically varying three factors: current maternal syphilis testing and treatment coverage, syphilis prevalence in pregnant women, and the cost of healthcare. We calculated program and net costs, DALYs averted, and net costs per DALY averted over four years in each scenario. Program costs are estimated at $4,142,287 - $8,235,796 per million pregnant women (2010 USD). Net costs, adjusted for averted medical care and current services, range from net savings of $12,261,250 to net costs of $1,736,807. The program averts an estimated 5,754 - 93,484 DALYs, yielding net savings in four scenarios, and a cost per DALY averted of $24 - $111 in the four scenarios with net costs. Results were robust in sensitivity analyses. CONCLUSIONS: Eliminating MTCT of syphilis through expanded screening and treatment in ANC is likely to be highly cost-effective by WHO-defined thresholds in a wide range of settings. Countries with high prevalence, low current service coverage, and high healthcare cost would benefit most. Future analyses can be tailored to countries using local epidemiologic and programmatic data.

Published
2014

32. Zika Virus in Rectal Swab Samples

Author

Botto-Menezes, Camila Helena Aguiar, Neto, Armando Menezes, Calvet, Guilherme Amaral, Kara, Edna Oliveira, Lacerda, Marcus Vinicius Guimaraes, Castilho, Marcia da Costa, Stroher, Ute, de Brito, Carlos Alexandre Antunes, Modjarrad, Kayvon, Broutet, Nathalie, Brasil, Patricia, de Filippis, Ana Maria Bispo, and Franca, Rafael Freitas Oliveira

Subjects
Transcription (Genetics) -- Health aspects, Medical research -- Health aspects, Zika virus -- Health aspects, Infection -- Prevention -- Health aspects, Genetic disorders -- Prevention -- Health aspects, RNA -- Health aspects, Polymerase chain reaction, Health
Abstract

In early 2015, Zika virus was identified in Brazil and spread across nearly the whole continent, affecting thousands of persons (1). This outbreak was associated with microcephaly and other congenital [...]

Published
2019
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33. Phase II trial evaluating the clinical efficacy of cefixime for treatment of active syphilis in non-pregnant women in Brazil (CeBra)

Author

Taylor, Melanie M., Kara, Edna Oliveira, Araujo, Maria Alix Leite, Silveira, Mariangela Freitas, Miranda, Angelica Espinosa, Branco Coelho, Ivo Castelo, Bazzo, Maria Luiza, Mendes Pereira, Gerson Fernando, Pereira Giozza, Silvana, Bermudez, Ximena Pamela Díaz, Mello, Maeve B., Habib, Ndema, Nguyen, My Huong, Thwin, Soe Soe, and Broutet, Nathalie

Published
2020
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40. World Health Organization Guidelines for treatment of cervical intraepithelial neoplasia 2–3 and screen-and-treat strategies to prevent cervical cancer

Author

Santesso, Nancy, Mustafa, Reem A., Schünemann, Holger J., Arbyn, Marc, Blumenthal, Paul D., Cain, Joanna, Chirenje, Michael, Denny, Lynette, De Vuyst, Hugo, Eckert, Linda O’Neal, Forhan, Sara E., Franco, Eduardo L., Gage, Julia C., Garcia, Francisco, Herrero, Rolando, Jeronimo, José, Lu, Enriquito R., Luciani, Silvana, Quek, Swee Chong, Sankaranarayanan, Rengaswamy, Tsu, Vivien, and Broutet, Nathalie

Published
2016
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45. Evaluation of the benefits and harms of alternative strategies for cervical screening and treatment in women living with HIV: modelling to support WHO 2021 cervical screening and treatment guidelines to prevent cervical cancer

Author

Hall, Michaela, primary, Simms, Kate, additional, Murray, John, additional, Keane, Adam, additional, Nguyen, TND, additional, Caruana, Michael, additional, Liu, Gigi, additional, Kelly, Helen, additional, Eckert, Lindo, additional, Santesso, Nancy, additional, DeSanjose, Silvia, additional, Swai, Edwin, additional, Rangaraj, Ajay, additional, Owiredu, Morkor Newman, additional, Gauvreau, Cindy, additional, Demke, Owen, additional, Basu, Partha, additional, Arbyn, Marc, additional, Dalal, Shona, additional, Broutet, Nathalie, additional, and Canfell, Karen, additional

Published
2022
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46. Benefits, harms and cost-effectiveness of cervical screening and treatment in 78 low-income and lower-middle income countries for women in the general population: modelling to support updated WHO cervical screening and treatment guidelines to prevent cervical cancer

Author

Simms, Kate, primary, Keane, Adam, additional, Nguyen, TND, additional, Caruana, Michael, additional, Hall, Michaela, additional, Lui, Gigi, additional, Gauvreau, Cindy, additional, Demke, Owen, additional, Arbyn, Marc, additional, Basu, Partha, additional, Wentzensen, Nicolas, additional, Lauby-Secretan, Beatrice, additional, Ilbawi, André, additional, Hutubessy, Raymond, additional, Almonte, Maribel, additional, DeSanjose, Silvia, additional, Kelly, Helen, additional, Dalal, Shona, additional, Eckert, Lindo, additional, Santesso, Nancy, additional, Broutet, Nathalie, additional, and Canfell, Karen, additional

Published
2022
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47. Implementing HPV testing in 9 Latin American countries: The laboratory perspective as observed in the ESTAMPA study

Author

Rol, Mary Luz, primary, Picconi, María Alejandra, additional, Ferrera, Annabelle, additional, Sánchez, Gloria Inés, additional, Hernández, María de la Luz, additional, Lineros, Joana, additional, Peraza, Ana, additional, Brizuela, Marisol, additional, Mendoza, Laura, additional, Mongelós, Pamela, additional, Cabrera, Yessy, additional, Rodríguez de la Peña, Margarita, additional, Correa, Rita Mariel, additional, Terán, Carolina, additional, Colque Reynaga, Deisy, additional, García, Laura, additional, Ramírez, Arianis Tatiana, additional, Hernández-Nevarez, Pilar, additional, Doimi, Franco, additional, Ramón, María, additional, Arias-Stella, Javier, additional, Zúñiga, Michael, additional, Villagra, Verónica, additional, Bobadilla, María Liz, additional, Cardinal, Lucía, additional, Valls, Joan, additional, Lucas, Eric, additional, Baena, Armando, additional, Fleider, Laura, additional, Venegas, Gino, additional, Cruz-Valdez, Aurelio, additional, Rodríguez, Guillermo, additional, Calderón, Alejandro, additional, Wiesner, Carolina, additional, Luciani, Silvana, additional, Broutet, Nathalie, additional, Herrero, Rolando, additional, and Almonte, Maribel, additional

Published
2022
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50. Understanding the public health value and defining preferred product characteristics for therapeutic human papillomavirus (HPV) vaccines: World Health Organization consultations, October 2021—March 2022

Author

Prudden, Holly J., primary, Achilles, Sharon L., additional, Schocken, Celina, additional, Broutet, Nathalie, additional, Canfell, Karen, additional, Akaba, Hiroki, additional, Basu, Partha, additional, Bhatla, Neerja, additional, Chirenje, Z. Mike, additional, Delany-Moretlwe, Sinead, additional, Denny, Lynette, additional, Gamage, Deepa G., additional, Herrero, Rolando, additional, Hutubessy, Raymond, additional, Villa, Luisa Lina, additional, Murillo, Raul, additional, Schiller, John T., additional, Stanley, Margaret, additional, Temmerman, Marleen, additional, Zhao, Fanghui, additional, Ogilvie, Gina, additional, Kaslow, David C., additional, Dull, Peter, additional, and Gottlieb, Sami L, additional

Published
2022
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