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Department of Biological Sciences (Botany Program), Gomal University, Dera Ismail Khan-29050, Pakistan Department of Botany, Pir Mehr Ali Shah Arid Agriculture University, Rawalpindi-46300, Pakistan E-mail: humaqureshi8@gmail.com Department of Environmental Science, Gomal University, Dera Ismail Khan-29050, Pakistan Department of Biology, Allama Iqbal Open University, Islamabad-46000, Pakistan Manuscript received online 15 October 2019, revised and accepted 06 January 2020 Phytochemistry is an important field of plant biology with a number of applied research applications. Whole metabolome based phytochemical analysis of plants is a technique that requires profiling of known compounds from the plant. In this paper, we present a detailed review of known phytochemistry of paper mulberry tree after a thorough survey of available literature as well as different databases (KnapSack, Plant metabolome database (PMDB), PubChem, ChemSpider) in favor of whole metabolome based phytochemical analysis. A detailed account of known phytochemistry of Broussonetia papyrifera sheds light on the multipurpose economic importance (medicinal, high quality fiber, severe pollen allergy, phytotoxic, invasive) of plant.