Search

Your search keyword '"Brott, Thomas G"' showing total 1,107 results
Start Over Author "Brott, Thomas G"
1,107 results on '"Brott, Thomas G"'

7. Associations of Perioperative Variables With the 30-Day Risk of Stroke or Death in Carotid Endarterectomy for Symptomatic Carotid Stenosis.

Author

Knappich, Christoph, Kuehnl, Andreas, Haller, Bernhard, Salvermoser, Michael, Algra, Ale, Becquemin, Jean-Pierre, Bonati, Leo H, Bulbulia, Richard, Calvet, David, Fraedrich, Gustav, Gregson, John, Halliday, Alison, Hendrikse, Jeroen, Howard, George, Jansen, Olav, Malas, Mahmoud B, Ringleb, Peter A, Brown, Martin M, Mas, Jean-Louis, Brott, Thomas G, Morris, Dylan R, Lewis, Steff C, and Eckstein, Hans-Henning

Subjects
Humans, Carotid Stenosis, Postoperative Complications, Anesthesia, Local, Anesthesia, General, Endarterectomy, Carotid, Risk Factors, Aged, Middle Aged, Female, Male, Stroke, anesthesia, death, endarterectomy, carotid, humans, stroke, Clinical Research, Neurosciences, Brain Disorders, endarterectomy, carotid, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Neurology & Neurosurgery
Abstract

Background and Purpose- This analysis was performed to assess the association between perioperative and clinical variables and the 30-day risk of stroke or death after carotid endarterectomy for symptomatic carotid stenosis. Methods- Individual patient-level data from the 5 largest randomized controlled carotid trials were pooled in the Carotid Stenosis Trialists' Collaboration database. A total of 4181 patients who received carotid endarterectomy for symptomatic stenosis per protocol were included. Determinants of outcome included carotid endarterectomy technique, type of anesthesia, intraoperative neurophysiological monitoring, shunting, antiplatelet medication, and clinical variables. Stroke or death within 30 days after carotid endarterectomy was the primary outcome. Adjusted risk ratios (aRRs) were estimated in multilevel multivariable analyses using a Poisson regression model. Results- Mean age was 69.5±9.2 years (70.7% men). The 30-day stroke or death rate was 4.3%. In the multivariable regression analysis, local anesthesia was associated with a lower primary outcome rate (versus general anesthesia; aRR, 0.70 [95% CI, 0.50-0.99]). Shunting (aRR, 1.43 [95% CI, 1.05-1.95]), a contralateral high-grade carotid stenosis or occlusion (aRR, 1.58 [95% CI, 1.02-2.47]), and a more severe neurological deficit (mRS, 3-5 versus 0-2: aRR, 2.51 [95% CI, 1.30-4.83]) were associated with higher primary outcome rates. None of the other characteristics were significantly associated with the perioperative stroke or death risk. Conclusions- The current results indicate lower perioperative stroke or death rates in patients operated upon under local anesthesia, whereas a more severe neurological deficit and a contralateral high-grade carotid stenosis or occlusion were identified as potential risk factors. Despite a possible selection bias and patients not having been randomized, these findings might be useful to guide surgeons and anesthetists when treating patients with symptomatic carotid disease.

Published
2019

12. Higher Risk for Reintervention in Patients after Stenting for Radiation-Induced Internal Carotid Artery Stenosis: A Single-Center Analysis and Systematic Review

Author

Erben, Young, Franco-Mesa, Camila, Miller, David, Lanzino, Giuseppe, Bendok, Bernard R., Li, Yupeng, Sandhu, Sukhwinder J.S., Barrett, Kevin M., Freeman, William D., Lin, Michelle, Huang, Josephine F., Huynh, Thien, Farres, Houssam, Brott, Thomas G., Hakaim, Albert G., Brigham, Tara J., Todnem, Nathan D., Tawk, Rabih G., and Meschia, James F.

Published
2021
Full Text
View/download PDF

19. Imaging in StrokeNet: Realizing the Potential of Big Data.

Author

Liebeskind, David S, Albers, Gregory W, Crawford, Karen, Derdeyn, Colin P, George, Mark S, Palesch, Yuko Y, Toga, Arthur W, Warach, Steven, Zhao, Wenle, Brott, Thomas G, Sacco, Ralph L, Khatri, Pooja, Saver, Jeffrey L, Cramer, Steven C, Wolf, Steven L, Broderick, Joseph P, and Wintermark, Max

Subjects
Humans, Brain Ischemia, Diagnostic Imaging, Statistics as Topic, Stroke, Neuroimaging, collateral circulation, diagnostic imaging, stroke, Neurology & Neurosurgery, Clinical Sciences, Cardiorespiratory Medicine and Haematology, Neurosciences
Published
2015

20. Effect of Patching on Reducing Restenosis in the Carotid Revascularization Endarterectomy Versus Stenting Trial

Author

Malas, Mahmoud, Glebova, Natalia O, Hughes, Susan E, Voeks, Jenifer H, Qazi, Umair, Moore, Wesley S, Lal, Brajesh K, Howard, George, Llinas, Rafael, and Brott, Thomas G

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Brain Disorders, Clinical Research, Cardiovascular, Clinical Trials and Supportive Activities, Stroke, Aged, Carotid Arteries, Carotid Stenosis, Endarterectomy, Carotid, Female, Heart Valve Diseases, Humans, Male, Middle Aged, Myocardial Infarction, Proportional Hazards Models, Prospective Studies, Risk, Stents, Treatment Outcome, carotid artery narrowing, carotid artery stenosis, carotid endarterectomy, vascular closure patches, Cardiorespiratory Medicine and Haematology, Neurosciences, Neurology & Neurosurgery, Clinical sciences, Allied health and rehabilitation science
Abstract

Background and purposeThe purpose is to determine whether patching during carotid endarterectomy (CEA) affects the perioperative and long-term risks of restenosis, stroke, death, and myocardial infarction as compared with primary closure.MethodsWe identified all patients who were randomized and underwent CEA in Carotid Revascularization Endarterectomy versus Stenting Trial. CEA patients who received a patch were compared with patients who underwent CEA with primary closure without a patch. We compared periprocedural and 4-year event rates, 2-year restenosis rates, and rates of reoperation between the 2 groups. We further analyzed results by surgeon specialty.ResultsThere were 1151 patients who underwent CEA (753 [65%] with patch and 329 [29%] with primary closure). We excluded 44 patients who underwent eversion CEA and 25 patients missing CEA data (5%). Patch use differed by surgeon specialty: 89% of vascular surgeons, 6% of neurosurgeons, and 76% of thoracic surgeons patched. Comparing patients who received a patch versus those who did not, there was a significant reduction in the 2-year risk of restenosis, and this persisted after adjustment by surgeon specialty (hazard ratio, 0.35; 95% confidence interval, 0.16-0.74; P=0.006). There were no significant differences in the rates of periprocedural stroke and death (hazard ratio, 1.58; 95% confidence interval, 0.33-7.58; P=0.57), in immediate reoperation (hazard ratio, 0.6; 95% confidence interval, 0.16-2.27; P=0.45), or in the 4-year risk of ipsilateral stroke (hazard ratio, 1.23; 95% confidence interval, 0.42-3.63; P=0.71).ConclusionsPatch closure in CEA is associated with reduction in restenosis although it is not associated with improved clinical outcomes. Thus, more widespread use of patching should be considered to improve long-term durability.Clinical trial registration urlhttp://www.clinicaltrials.gov. Unique identifier: NCT00004732.

Published
2015

21. Quality Assurance for Carotid Stenting in the CREST-2 Registry

Author

Lal, Brajesh K., Roubin, Gary S., Rosenfield, Kenneth, Heck, Donald, Jones, Michael, Jankowitz, Brian, Jovin, Tudor, Chaturvedi, Seemant, Dabus, Guilherme, White, Christopher J., Gray, William, Matsumura, Jon, Katzen, Barry T., Hopkins, L. Nelson, Mayorga-Carlin, Minerva, Sorkin, John D., Howard, George, Meschia, James F., and Brott, Thomas G.

Published
2019
Full Text
View/download PDF

24. Long-term outcomes of stenting and endarterectomy for symptomatic carotid stenosis: a preplanned pooled analysis of individual patient data

Author

Brott, Thomas G, Calvet, David, Howard, George, Gregson, John, Algra, Ale, Becquemin, Jean-Pierre, de Borst, Gert J, Bulbulia, Richard, Eckstein, Hans-Henning, Fraedrich, Gustav, Greving, Jacoba P, Halliday, Alison, Hendrikse, Jeroen, Jansen, Olav, Voeks, Jenifer H, Ringleb, Peter A, Mas, Jean-Louis, Brown, Martin M, and Bonati, Leo H

Published
2019
Full Text
View/download PDF

35. Association between age and risk of stroke or death from carotid endarterectomy and carotid stenting: a meta-analysis of pooled patient data from four randomised trials

Author

Howard, George, Roubin, Gary S, Jansen, Olav, Hendrikse, Jeroen, Halliday, Alison, Fraedrich, Gustav, Eckstein, Hans-Henning, Calvet, David, Bulbulia, Richard, Bonati, Leo H, Becquemin, Jean-Pierre, Algra, Ale, Brown, Martin M, Ringleb, Peter A, Brott, Thomas G, and Mas, Jean-Louis

Published
2016
Full Text
View/download PDF

37. Secular Trends in Procedural Stroke or Death Risks of Stenting Versus Endarterectomy for Symptomatic Carotid Stenosis: A Pooled Analysis of Randomized Trials

Author

Müller, Mandy D., von Felten, Stefanie, Algra, Ale, Becquemin, Jean-Pierre, Bulbulia, Richard, Calvet, David, Eckstein, Hans-Henning, Fraedrich, Gustav, Halliday, Alison, Hendrikse, Jeroen, Howard, George, Gregson, John, Jansen, Olav, Brown, Martin M., Mas, Jean-Louis, Brott, Thomas G., Ringleb, Peter A., and Bonati, Leo H.

Published
2019
Full Text
View/download PDF

38. Safety of Carotid Revascularization in Patients With a History of Coronary Heart Disease

Author

Volkers, Eline J., Algra, Ale, Kappelle, L. Jaap, Becquemin, Jean-Pierre, de Borst, Gert J., Brown, Martin M., Bulbulia, Richard, Calvet, David, Eckstein, Hans-Henning, Fraedrich, Gustav, Gregson, John, Halliday, Alison, Hendrikse, Jeroen, Howard, George, Jansen, Olav, Roubin, Gary S., Bonati, Leo H., Brott, Thomas G., Mas, Jean-Louis, Ringleb, Peter A., and Greving, Jacoba P.

Published
2019
Full Text
View/download PDF

41. Cortical Thinning in High-Grade Asymptomatic Carotid Stenosis

Author

Marshall, Randolph S., primary, Liebeskind, David S., additional, III, John Huston, additional, Edwards, Lloyd J., additional, Howard, George, additional, Meschia, James F., additional, Brott, Thomas G., additional, Lal, Brajesh K., additional, Heck, Donald, additional, Lanzino, Giuseppe, additional, Sangha, Navdeep, additional, Kashyap, Vikram S., additional, Morales, Clarissa D., additional, Cotton-Samuel, Dejania, additional, Rivera, Andres M., additional, Brickman, Adam M., additional, and Lazar, Ronald M., additional

Published
2023
Full Text
View/download PDF

47. Prediction Models for Clinical Outcome After a Carotid Revascularization Procedure: An External Validation Study

Author

Volkers, Eline J., Algra, Ale, Kappelle, L. Jaap, Jansen, Olav, Howard, George, Hendrikse, Jeroen, Halliday, Alison, Gregson, John, Fraedrich, Gustav, Eckstein, Hans-Henning, Calvet, David, Bulbulia, Richard, Brown, Martin M., Becquemin, Jean-Pierre, Ringleb, Peter A., Mas, Jean-Louis, Bonati, Leo H., Brott, Thomas G., and Greving, Jacoba P.

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results