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256 results on '"Brosstad, Frank"'

5. Triglyceride-rich [HDL.sub.3] from patients with familial hypercholesterolemia are less able to inhibit cytokine release or to promote cholesterol efflux

Author

Ottestad, Inger O., Halvorsen, Bente, Balstad, Trude R., Otterdal, Kari, Borge, Grethe I., Brosstad, Frank, Myhre, Anne M., Ose, Leiv, Nenseter, Marit S., and Holven, Kirsten B.

Subjects
Biological markers -- Usage, Cardiac patients -- Health aspects, High density lipoproteins -- Research, Hypercholesterolemia -- Risk factors, Hypercholesterolemia -- Research, Food/cooking/nutrition
Abstract

Familial hypercholesterolemia (FH) is associated with heterogeneity of the onset and severity of coronary heart disease (CHD). In this study, we investigated different low-grade proinflammatory markers and the atheroprotective function of the [HDL.sub.3] subfraction in FH-patients (n = 13) with identical LDL-receptor mutations and in age- and sex-matched healthy controls (n = 11). Compared with healthy controls, FH-patients had greater gene expressions of the proatherogenic mediators TNF-[alpha] and IL-8 in circulating peripheral blood mononuclear cells. In addition, they had a higher serum concentration of intercellular adhesion molecule-1 (ICAM-1) and a lower net antioxidant capacity. FH-derived [HDL.sub.3] with a high level of triglycerides had a reduced capacity to inhibit the release of IL-8 from TNF-[alpha]-stimulated human umbilical vein endothelial cells (HUVEC) [1.864 mg/L (1.461-2.208 mg/L) vs. 1.466 mg/L (1.225-1.643 mg/L); P < 0.05; median (range)], and a reduced capacity to promote cholesterol efflux from lipid-loaded macrophages [12% (12-14%) vs. 15% (14-18%); P < 0.05; median (range)] compared with [HDL.sub.3] with a lower triglyceride content. Notably, the degree of inhibition of IL-8 release from HUVEC by [HDL.sub.3] was correlated with the ability of [HDL.sub.3] to promote cholesterol efflux (r = 0.80, P = 0.03). In conclusion, compared with healthy controls, FH-patients are characterized by higher levels of low-grade proinflammatory markers, and FH-derived [HDL.sub.3] with high triglyceride content may be more proatherogenic. These triglyceride rich-[HDL.sub.3] might be partly responsible for the phenotypic variation among FH-patients with identical LDL-receptor mutations. KEY WORDS: * familial hypercholesterolemia; high density lipoprotein * coronary heart disease * cytokines * cholesterol efflux

Published
2006

24. Systemic biomarkers of inflammation and haemostasis in patients with chronic necrotizing pulmonary aspergillosis

Author

Rødland Ernst, Ueland Thor, Bjørnsen Stine, Sagen Ellen, Dahl Christen, Naalsund Anne, Mollnes Tom, Brosstad Frank R, Müller Fredrik, Aukrust Pål, and Frøland Stig S

Subjects
CNPA, Inflammation, Haemostasis, Biomarkers, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background The purpose of this study was to investigate mediators of inflammation and haemostasis in patients with chronic necrotizing pulmonary aspergillosis (CNPA), a locally, destructive process of the lung due to invasion by Aspergillus species. Methods Measurements of selected biomarkers in 10 patients with CNPA and 19 healthy, matched controls were performed with enzyme-linked immunosorbent assay (ELISA) and multiplex methodology. The gene expressions of relevant biomarkers were analyzed with real-time quantitative RT-PCR. Results Increased concentrations of circulating mediators of inflammation interleukin (IL)-6, IL-8, RANTES, TNF-α, ICAM-1 and mediators involved in endothelial activation and thrombosis (vWF, TF and PAI-1) were observed in patients with CNPA. The concentration of the anti-inflammatory cytokine IL-10 was increased both in plasma and in PBMC in the patient population. The gene expression of CD40L was decreased in PBMC from the patient group, accompanied by decreased concentrations of soluble (s) CD40L in the circulation. Conclusions The proinflammatory response against Aspergillus may be counteracted by reduced CD40L and sCD40L, as well as increased IL-10, which may compromise the immune response against Aspergillus in patients with CNPA.

Published
2012
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25. Levels of Lipoprotein (a) in patients with coronary artery disease with and without inflammatory rheumatic disease: a cross-sectional study

Author

Holm, Sverre, primary, Oma, Ingvild, additional, Hagve, Tor-Arne, additional, Saatvedt, Kjell, additional, Brosstad, Frank, additional, Mikkelsen, Knut, additional, Rydningen, Hans, additional, Risnes, Ivar, additional, Almdahl, Sven Martin, additional, Ueland, Thor, additional, Aukrust, Pål, additional, Halvorsen, Bente, additional, and Hollan, Ivana, additional

Published
2019
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41. Increased YKL-40 expression in patients with carotid atherosclerosis

Author

Michelsen, Annika E., primary, Rathcke, Camilla N., additional, Skjelland, Mona, additional, Holm, Sverre, additional, Ranheim, Trine, additional, Krohg-Sørensen, Kirsten, additional, Klingvall, Marit F., additional, Brosstad, Frank, additional, Øie, Erik, additional, Vestergaard, Henrik, additional, Aukrust, Pål, additional, and Halvorsen, Bente, additional

Published
2010
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44. Inflammatory Interaction Between LIGHT and Proteinase-Activated Receptor-2 in Endothelial Cells

Author

Sandberg, Wiggo J., primary, Halvorsen, Bente, additional, Yndestad, Arne, additional, Smith, Camilla, additional, Otterdal, Kari, additional, Brosstad, Frank R., additional, Frøland, Stig S., additional, Olofsson, Peder S., additional, Damås, Jan K., additional, Gullestad, Lars, additional, Hansson, Göran K., additional, Øie, Erik, additional, and Aukrust, Pål, additional

Published
2009
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