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Dissertation, RWTH Aachen University, 2021; Aachen : RWTH Aachen University 1 Online-Ressource : Illustrationen (2021). = Dissertation, RWTH Aachen University, 2021, The presented thesis covers three research topics concerning sulfur chemistry. The main focus of this work lays on the compound class of sulfoximines. First, the syntheses of sulfur-based building blocks for their incorporation into BN- and BO-doped inorganic-organic hybrid polymers is discussed. Secondly, different derivatizations of sulfoximines are examined. N-Oximsulfoximines are synthesized by a reaction between imidoylchlorides and free NH-sulfoximines under basic conditions. Further, a [3+2]-cycloaddition between N-cyanosulfoximines and nitrones is investigated. Also, the reaction of N-cyanosulfoximines and acyl Meldrum’s acid derivatives leading to 5-carbonyl-1,3-oxazine-2,4-dione N-substituted sulfoximines is explored. The third part of this thesis deals with the syntheses of sulfoximine analogues of bioactive compounds. First a sulfoximine analogue of Sulfasalazine was synthesized and tested in vitro against different cancer cell lines. Secondly the synthesis of a Pimozide sulfoximine analogue is described. A precursor of this analogue was obtained., Published by RWTH Aachen University, Aachen

At elevated temperatures, N-cyanosulfoximines react with Meldrum’s acid derivatives to give sulfoximines with N-bound 5-carbonyl-1,3-oxazine-2,4-dione groups. A representative product was characterized by single-crystal X-ray structure analysis. The product formation involves an unexpected molecular reorientation requiring several sequential bond-forming and -cleaving processes. peerReviewed