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7 results on '"Bronnec, Pauline"'

3. Steroid hormone catabolites activate the pyrin inflammasome through a non-canonical mechanism

Author

Magnotti, Flora, Chirita, Daria, Dalmon, Sarah, Martin, Amandine, Bronnec, Pauline, Sousa, Jeremy, Helynck, Olivier, Lee, Wonyong, Kastner, Daniel L., Chae, Jae Jin, McDermott, Michael F., Belot, Alexandre, Popoff, Michel, Sève, Pascal, Georgin-Lavialle, Sophie, Munier-Lehmann, Hélène, Tran, Tu Anh, De Langhe, Ellen, Wouters, Carine, Jamilloux, Yvan, and Henry, Thomas

Published
2022
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5. Steroid hormone catabolites activate the pyrin inflammasome through a non-canonical mechanism

Author

Magnotti, Flora, primary, Chirita, Daria, additional, Dalmon, Sarah, additional, Martin, Amandine, additional, Bronnec, Pauline, additional, Sousa, Jeremy, additional, Helynck, olivier, additional, Lee, Wonyong, additional, Kastner, Daniel, additional, Chae, Jae Jin, additional, McDermott, Michael, additional, Belot, alexandre, additional, Popoff, Michel, additional, Seve, Pascal, additional, Georgin-Lavialle, Sophie, additional, Munier-Lehmann, Helene, additional, TRAN, Tu anh, additional, De Langhe, Ellen, additional, Wouters, Carine, additional, Jamilloux, Yvan, additional, and Henry, Thomas, additional

Published
2021
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6. RAC2 gain-of-function variants causing inborn error of immunity drive NLRP3 inflammasome activation

Author

Doye, Anne, Chaintreuil, Paul, Lagresle-Peyrou, Chantal, Batistic, Ludovic, Marion, Valentine, Munro, Patrick, Loubatier, Celine, Chirara, Rayana, Sorel, Nataël, Bessot, Boris, Bronnec, Pauline, Contenti, Julie, Courjon, Johan, Giordanengo, Valerie, Jacquel, Arnaud, Barbry, Pascal, Couralet, Marie, Aladjidi, Nathalie, Fischer, Alain, Cavazzana, Marina, Mallebranche, Coralie, Visvikis, Orane, Kracker, Sven, Moshous, Despina, Verhoeyen, Els, and Boyer, Laurent

Abstract

A growing number of patients presenting severe combined immunodeficiencies attributed to monoallelic RAC2 variants have been identified. The expression of the RHO GTPase RAC2 is restricted to the hematopoietic lineage. RAC2 variants have been described to cause immunodeficiencies associated with high frequency of infection, leukopenia, and autoinflammatory features. Here, we show that specific RAC2 activating mutations induce the NLRP3 inflammasome activation leading to the secretion of IL-1β and IL-18 from macrophages. This activation depends on the activation state of the RAC2 variant and is mediated by the downstream kinase PAK1. Inhibiting the RAC2–PAK1–NLRP3 inflammasome pathway might be considered as a potential treatment for these patients.

Published
2024
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7. Inducing Pyroptosis Via the Pyrin Inflammasome.

Author

Bronnec P, Sousa J, and Henry T

Subjects
Humans, Mice, Animals, Pyrin, Pyroptosis, Cell Death, NLR Family, Pyrin Domain-Containing 3 Protein, Inflammasomes metabolism, Bacterial Toxins genetics
Abstract

The pyrin inflammasome detects bacterial toxins and effectors that inhibit RhoA GTPases and triggers inflammatory cytokine release and a fast cell death termed pyroptosis. In addition, various endogenous molecules, drugs, synthetic molecules, or mutations can trigger pyrin inflammasome activation. The pyrin protein differs between humans and mice, and the repertoire of pyrin activators is also species-specific. Here, we present the various pyrin inflammasome activators, inhibitors, the kinetics of pyrin activation in response to the various activators, and their species specificity. In addition, we present different methods to monitor pyrin-mediated pyroptosis., (© 2023. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.)

Published
2023
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