Search

Your search keyword '"Bronk, Julianna"' showing total 37 results
Start Over Author "Bronk, Julianna"
37 results on '"Bronk, Julianna"'

1. Mimicking large spot-scanning radiation fields for proton FLASH preclinical studies with a robotic motion platform

Author

Guan, Fada, Jiang, Dadi, Wang, Xiaochun, Yang, Ming, Iga, Kiminori, Li, Yuting, Bronk, Lawrence, Bronk, Julianna, Wang, Liang, Guo, Youming, Sahoo, Narayan, Grosshans, David R., Koong, Albert C., Zhu, Xiaorong R., and Mohan, Radhe

Subjects
Physics - Medical Physics
Abstract

Previously, a synchrotron-based horizontal proton beamline (87.2 MeV) was successfully commissioned to deliver radiation doses in FLASH and conventional dose rate modes to small fields and volumes. In this study, we developed a strategy to increase the effective radiation field size using a custom robotic motion platform to automatically shift the positions of biological samples. The beam was first broadened with a thin tungsten scatterer and shaped by customized brass collimators for irradiating cell/organoid cultures in 96-well plates (a 7-mm-diameter circle) or for irradiating mice (1-cm2 square). Motion patterns of the robotic platform were written in G-code, with 9-mm spot spacing used for the 96-well plates and 10.6-mm spacing for the mice. The accuracy of target positioning was verified with a self-leveling laser system. The dose delivered in the experimental conditions was validated with EBT-XD film attached to the 96-well plate or the back of the mouse. Our film-measured dose profiles matched Monte Carlo calculations well (1D gamma pass rate >95%). The FLASH dose rates were 113.7 Gy/s for cell/organoid irradiation and 191.3 Gy/s for mouse irradiation. These promising results indicate that this robotic platform can be used to effectively increase the field size for preclinical experiments with proton FLASH.

Published
2024
Full Text
View/download PDF

2. Patterns of loco-regional progression and patient outcomes after definitive-dose radiation therapy for anaplastic thyroid cancer

Author

Bronk, Julianna K., Augustyn, Alexander, Mohamed, Abdallah S.R., David Fuller, C., Garden, Adam S., Moreno, Amy C., Lee, Anna, Morrison, William H., Phan, Jack, Reddy, Jay P., Rosenthal, David I., Spiotto, Michael T., Frank, Steven J., Dadu, Ramona, Busaidy, Naifa, Zafereo, Mark, Wang, Jennifer R., Maniakas, Anastasios, Ferrarotto, Renata, Iyer, Priyanka C., Cabanillas, Maria E., and Gunn, G. Brandon

Published
2025
Full Text
View/download PDF

4. Exploratory analysis of the cervix tumoral HPV antigen-specific T-cell repertoire during chemoradiation and after brachytherapy

Author

Manzar, Gohar S., Alam, Molly B. El, Lynn, Erica J., Karpinets, Tatiana V., Harris, Timothy, Lo, David, Yoshida-Court, Kyoko, Napravnik, Tatiana Cisneros, Sammouri, Julie, Lin, Daniel, Andring, Lauren M., Bronk, Julianna, Wu, Xiaogang, Sims, Travis T., Mathew, Geena, Schmeler, Kathleen M., Eifel, Patricia J., Jhingran, Anuja, Lin, Lilie L., Joyner, Melissa M., Zhang, Jianhua, Futreal, Andrew, Klopp, Ann H., and Colbert, Lauren E.

Published
2024
Full Text
View/download PDF

5. Tumor-resident Lactobacillus iners confer chemoradiation resistance through lactate-induced metabolic rewiring

Author

Colbert, Lauren E., El Alam, Molly B., Wang, Rui, Karpinets, Tatiana, Lo, David, Lynn, Erica J., Harris, Timothy A., Elnaggar, Jacob H., Yoshida-Court, Kyoko, Tomasic, Katarina, Bronk, Julianna K., Sammouri, Julie, Yanamandra, Ananta V., Olvera, Adilene V., Carlin, Lily G., Sims, Travis, Delgado Medrano, Andrea Y., Napravnik, Tatiana Cisneros, O’Hara, Madison, Lin, Daniel, Abana, Chike O., Li, Hannah X., Eifel, Patricia J., Jhingran, Anuja, Joyner, Melissa, Lin, Lilie, Ramondetta, Lois M., Futreal, Andrew M., Schmeler, Kathleen M., Mathew, Geena, Dorta-Estremera, Stephanie, Zhang, Jianhua, Wu, Xiaogang, Ajami, Nadim J., Wong, Matthew, Taniguchi, Cullen, Petrosino, Joseph F., Sastry, K. Jagannadha, Okhuysen, Pablo C., Martinez, Sara A., Tan, Lin, Mahmud, Iqbal, Lorenzi, Philip L., Wargo, Jennifer A., and Klopp, Ann H.

Published
2023
Full Text
View/download PDF

6. Circulating neutrophils and tumor-associated myeloid cells function as a powerful biomarker for response to chemoradiation in locally advanced cervical cancer

Author

Gjyshi, Olsi, Grippin, Adam, Andring, Lauren, Jhingran, Anuja, Lin, Lilie L., Bronk, Julianna, Eifel, Patricia J., Joyner, Melissa M., Sastry, Jagannadha K., Yoshida-Court, Kyoko, Solley, Travis N., Napravnik, Tatiana Cisneros, O'Hara, Madison P., Hegde, Venkatesh L, Colbert, Lauren E., and Klopp, Ann H

Published
2023
Full Text
View/download PDF

7. Salvage Reirradiation with Proton Beam Therapy for Locoregionally Recurrent Non-Small Cell Lung Cancer.

Author

Ning, Matthew S., Odwuor, Abigael, Chang, Joe Y., Gandhi, Saumil, Liao, Zhongxing, Lin, Steven H., Chen, Aileen, Welsh, James W., Nguyen, Quynh-Nhu, O'Reilly, Michael S., Chun, Stephen G., Bronk, Julianna, Qian, David, and Lee, Percy

Subjects
PROTON therapy, CANCER relapse, SALVAGE therapy, LOGISTIC regression analysis, TREATMENT effectiveness, DESCRIPTIVE statistics, MANN Whitney U Test, RETROSPECTIVE studies, KAPLAN-Meier estimator, LUNG cancer, DATA analysis software, CONFIDENCE intervals, PROPORTIONAL hazards models
Abstract

Simple Summary: Roughly 25% of non-small cell lung cancer (NSCLC) patients subsequently experience isolated locoregional recurrence following definitive radiation therapy (RT). For these scenarios, thoracic reirradiation (re-RT) has become an increasingly common consideration, with improved feasibility due to technological advancements that have made it safer to deliver high doses of RT in the retreatment setting. Proton beam therapy (PBT) is an attractive choice for re-RT due to its ability to spare radiation to adjacent previously treated normal tissues. Here, we evaluate outcomes with PBT for the definitive re-RT of recurrent NSCLC within the previously irradiated thorax. Background/Objectives: This retrospective study evaluates outcomes of 66 patients who underwent reirradiation (re-RT) with proton beam therapy (PBT) for recurrent non-small cell lung cancer. Methods: Toxicity was scored via the CTCAE v5.0, and outcomes estimated using the Kaplan–Meier method, with associations evaluated via Cox proportional hazards and logistic regression analyses. Results: Patients were treated to a median re-RT prescription of 66 Gy/33 fxs (BED10 = 79 Gy; IQR: 71–84 Gy) at an interval of 1.4 years from prior RT. Half (50%) received concurrent chemotherapy. At 14 months follow-up, the median OS and PFS were 5 months (95%CI: 13–17) and 12.5 months (95%CI: 10–15), respectively. On multivariable analysis, a higher RT dose (BED10 > 70 Gy) [HR0.37; 95%CI: 0.20–0.68, p = 0.001] and concurrent chemotherapy (HR0.48; 95%CI: 0.28–0.81, p = 0.007) were associated with improved PFS, while treatment site overlap was adversely associated (HR1.78; 95%CI: 1.05–3.02, p = 0.031). The median PFS for definitive RT with concurrent chemotherapy (n = 28), definitive RT alone (BED10 > 70 Gy) [n = 22], and lower prescription RT (BED10 < 70 Gy) [n = 16] was 15.5 months (95%CI: 7.3–23.7), 14.1 months (95%CI: 10.9–17.3), and 3.3 months (95%CI: 0–12.3), respectively (log-rank, p = 0.006), with corresponding 2-year estimates of 37% (±9), 18% (±8), and 12.5% (±8), respectively. The incidence of Grade 3+ toxicity was 10.5% (6% pulmonary; 3% esophageal; and 1.5% skin), including one Grade 4 bronchopulmonary hemorrhage but no Grade 5 events. Cases with central site overlap had higher composite Dmax to the esophagus (median 87 Gy [IQR:77–90]), great vessels (median 120 Gy [IQR:110–138]), and proximal bronchial tree (median 120 Gy [IQR:110–138]) as compared to other cases (p ≤ 0.001 for all). However, no significant associations were identified with Grade 3+ events. Conclusions: Thoracic re-RT with PBT is an option for recurrent NSCLC with acceptable outcomes and toxicity for select patients. When feasible, higher prescription doses (BED10 > 70 Gy) should be delivered for definitive intent, and concurrent chemotherapy may benefit individual cases. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

8. Abstract A029: DDR pathway genes in CRT resistance: Insights from longitudinal whole exome sequencing in cervical cancer

Author

Ehsan, Shafqat F., primary, Wang, Rui, additional, Wu, Xiaogang, additional, Karpinets, Tatiana V., additional, Bronk, Julianna K., additional, Kapadia, Chiraag, additional, Song, Xingzhi, additional, Futreal, Andrew M., additional, Klopp, Ann H., additional, Harris, Tim, additional, Zhang, Jianhua, additional, and Colbert, Lauren E., additional

Published
2024
Full Text
View/download PDF

10. Exploratory analysis of the cervix tumoral HPV antigen-specific T-cell repertoire during chemoradiation and after brachytherapy

Author

Manzar, Gohar S., primary, Alam, Molly B. El, additional, Lynn, Erica J., additional, Karpinets, Tatiana V., additional, Harris, Timothy, additional, Lo, David, additional, Yoshida-Court, Kyoko, additional, Napravnik, Tatiana Cisneros, additional, Sammouri, Julie, additional, Lin, Daniel, additional, Andring, Lauren M., additional, Bronk, Julianna, additional, Wu, Xiaogang, additional, Sims, Travis T., additional, Mathew, Geena, additional, Schmeler, Kathleen M., additional, Eifel, Patricia J., additional, Jhingran, Anuja, additional, Lin, Lilie L., additional, Joyner, Melissa M., additional, Zhang, Jianhua, additional, Futreal, Andrew, additional, Klopp, Ann H., additional, and Colbert, Lauren E., additional

Published
2023
Full Text
View/download PDF

14. 1479: Preliminary Results of a Bayesian Adaptive Radiotherapy Trial to Reduce Cardiac Toxicity in NSCLC

Author

Lin, Ruitao, Zhang, Xiaodong, Xu, Tianlin, Xu, Ting, Maguire, Rachel, Corrigan, Kelsey, Koutroumpakis, Efstratios, Chang, Joe, Lin, Steven, Chen, Aileen, Nguyen, Quynh-Nhu, Gandhi, Saumil, Ning, Matthew, Bronk, Julianna, Chun, Stephen, Ajdari, Ali, Niedzielski, Joshua, Yang, Jinzhong, Chen, Xinru, Pan, Tinsu, Meng, Qing, Tsao, Anne, Mohan, Radhe, Deswal, Anita, and Liao, Zhongxing

Published
2024
Full Text
View/download PDF

17. Supplemental Tables from Expansion of Candidate HPV-Specific T Cells in the Tumor Microenvironment during Chemoradiotherapy Is Prognostic in HPV16+ Cancers

Author

Colbert, Lauren E., primary, El, Molly B., primary, Lynn, Erica J., primary, Bronk, Julianna, primary, Karpinets, Tatiana V., primary, Wu, Xiaogang, primary, Chapman, Bhavana V., primary, Sims, Travis T., primary, Lin, Daniel, primary, Kouzy, Ramez, primary, Sammouri, Julie, primary, Biegert, Greyson, primary, Delgado Medrano, Andrea Y., primary, Olvera, Adilene, primary, Sastry, K. Jagannadha, primary, Eifel, Patricia J., primary, Jhingran, Anuja, primary, Lin, Lilie, primary, Ramondetta, Lois M., primary, Futreal, Andrew P., primary, Jazaeri, Amir A., primary, Schmeler, Kathleen M., primary, Yue, Jingyan, primary, Mitra, Aparna, primary, Yoshida-Court, Kyoko, primary, Wargo, Jennifer A., primary, Solley, Travis N., primary, Hegde, Venkatesh, primary, Nookala, Sita S., primary, Yanamandra, Ananta V., primary, Dorta-Estremera, Stephanie, primary, Mathew, Geena, primary, Kavukuntla, Rohit, primary, Papso, Cassidy, primary, Ahmed-Kaddar, Mustapha, primary, Kim, Minsoo, primary, Zhang, Jianhua, primary, Reuben, Alexandre, primary, Holliday, Emma B., primary, Minsky, Bruce D., primary, Koong, Albert C., primary, Koay, Eugene J., primary, Das, Prajnan, primary, Taniguchi, Cullen M., primary, and Klopp, Ann, primary

Published
2023
Full Text
View/download PDF

18. Data from Expansion of Candidate HPV-Specific T Cells in the Tumor Microenvironment during Chemoradiotherapy Is Prognostic in HPV16+ Cancers

Author

Colbert, Lauren E., primary, El, Molly B., primary, Lynn, Erica J., primary, Bronk, Julianna, primary, Karpinets, Tatiana V., primary, Wu, Xiaogang, primary, Chapman, Bhavana V., primary, Sims, Travis T., primary, Lin, Daniel, primary, Kouzy, Ramez, primary, Sammouri, Julie, primary, Biegert, Greyson, primary, Delgado Medrano, Andrea Y., primary, Olvera, Adilene, primary, Sastry, K. Jagannadha, primary, Eifel, Patricia J., primary, Jhingran, Anuja, primary, Lin, Lilie, primary, Ramondetta, Lois M., primary, Futreal, Andrew P., primary, Jazaeri, Amir A., primary, Schmeler, Kathleen M., primary, Yue, Jingyan, primary, Mitra, Aparna, primary, Yoshida-Court, Kyoko, primary, Wargo, Jennifer A., primary, Solley, Travis N., primary, Hegde, Venkatesh, primary, Nookala, Sita S., primary, Yanamandra, Ananta V., primary, Dorta-Estremera, Stephanie, primary, Mathew, Geena, primary, Kavukuntla, Rohit, primary, Papso, Cassidy, primary, Ahmed-Kaddar, Mustapha, primary, Kim, Minsoo, primary, Zhang, Jianhua, primary, Reuben, Alexandre, primary, Holliday, Emma B., primary, Minsky, Bruce D., primary, Koong, Albert C., primary, Koay, Eugene J., primary, Das, Prajnan, primary, Taniguchi, Cullen M., primary, and Klopp, Ann, primary

Published
2023
Full Text
View/download PDF

19. Abstract 2375: Whole exome sequencing and immune profiling of cervical adenocarcinoma reveal a “cold” tumor-immune phenotype

Author

Bronk, Julianna, primary, Wu, Xiaogang, additional, Wang, Rui, additional, Yanamandra, Ananta, additional, Karpinets, Tatiana, additional, Abana, Chike, additional, Alam, Molly El, additional, Tomasic, Katarina, additional, Lin, Daniel, additional, Lynn, Erica, additional, Lo, David, additional, Harris, Timothy, additional, Song, Xingzhi, additional, Futreal, Andrew, additional, Zhang, Jianhua, additional, Sastry, Jagannadha, additional, Klopp, Ann, additional, and Colbert, Lauren, additional

Published
2023
Full Text
View/download PDF

20. Supplemental Table Legends from Expansion of Candidate HPV-Specific T Cells in the Tumor Microenvironment during Chemoradiotherapy Is Prognostic in HPV16+ Cancers

Author

Colbert, Lauren E., primary, El, Molly B., primary, Lynn, Erica J., primary, Bronk, Julianna, primary, Karpinets, Tatiana V., primary, Wu, Xiaogang, primary, Chapman, Bhavana V., primary, Sims, Travis T., primary, Lin, Daniel, primary, Kouzy, Ramez, primary, Sammouri, Julie, primary, Biegert, Greyson, primary, Delgado Medrano, Andrea Y., primary, Olvera, Adilene, primary, Sastry, K. Jagannadha, primary, Eifel, Patricia J., primary, Jhingran, Anuja, primary, Lin, Lilie, primary, Ramondetta, Lois M., primary, Futreal, Andrew P., primary, Jazaeri, Amir A., primary, Schmeler, Kathleen M., primary, Yue, Jingyan, primary, Mitra, Aparna, primary, Yoshida-Court, Kyoko, primary, Wargo, Jennifer A., primary, Solley, Travis N., primary, Hegde, Venkatesh, primary, Nookala, Sita S., primary, Yanamandra, Ananta V., primary, Dorta-Estremera, Stephanie, primary, Mathew, Geena, primary, Kavukuntla, Rohit, primary, Papso, Cassidy, primary, Ahmed-Kaddar, Mustapha, primary, Kim, Minsoo, primary, Zhang, Jianhua, primary, Reuben, Alexandre, primary, Holliday, Emma B., primary, Minsky, Bruce D., primary, Koong, Albert C., primary, Koay, Eugene J., primary, Das, Prajnan, primary, Taniguchi, Cullen M., primary, and Klopp, Ann, primary

Published
2023
Full Text
View/download PDF

21. Supplementary Data from Expansion of Candidate HPV-Specific T Cells in the Tumor Microenvironment during Chemoradiotherapy Is Prognostic in HPV16+ Cancers

Author

Colbert, Lauren E., primary, El, Molly B., primary, Lynn, Erica J., primary, Bronk, Julianna, primary, Karpinets, Tatiana V., primary, Wu, Xiaogang, primary, Chapman, Bhavana V., primary, Sims, Travis T., primary, Lin, Daniel, primary, Kouzy, Ramez, primary, Sammouri, Julie, primary, Biegert, Greyson, primary, Delgado Medrano, Andrea Y., primary, Olvera, Adilene, primary, Sastry, K. Jagannadha, primary, Eifel, Patricia J., primary, Jhingran, Anuja, primary, Lin, Lilie, primary, Ramondetta, Lois M., primary, Futreal, Andrew P., primary, Jazaeri, Amir A., primary, Schmeler, Kathleen M., primary, Yue, Jingyan, primary, Mitra, Aparna, primary, Yoshida-Court, Kyoko, primary, Wargo, Jennifer A., primary, Solley, Travis N., primary, Hegde, Venkatesh, primary, Nookala, Sita S., primary, Yanamandra, Ananta V., primary, Dorta-Estremera, Stephanie, primary, Mathew, Geena, primary, Kavukuntla, Rohit, primary, Papso, Cassidy, primary, Ahmed-Kaddar, Mustapha, primary, Kim, Minsoo, primary, Zhang, Jianhua, primary, Reuben, Alexandre, primary, Holliday, Emma B., primary, Minsky, Bruce D., primary, Koong, Albert C., primary, Koay, Eugene J., primary, Das, Prajnan, primary, Taniguchi, Cullen M., primary, and Klopp, Ann, primary

Published
2023
Full Text
View/download PDF

23. Saturday, June 18, 20222:00 PM - 3:00 PM PL01 Presentation Time: 2:00 PM

Author

Manzar, Gohar Shahwar, primary, Lo, David, additional, El-Alam, Molly, additional, Lynn, Erica, additional, Harris, Timothy, additional, Sammouri, Julie, additional, Andring, Lauren, additional, Bronk, Julianna, additional, Karipnets, Tatiana, additional, Wu, Xiaogang, additional, Sims, Travis, additional, Sastry, Jagannadha, additional, Mathew, Geena, additional, Schmeler, Kathleen, additional, Eifel, Patricia, additional, Jhingran, Anuja, additional, Lin, Lilie, additional, Joyner, Melissa, additional, Zhang, JIanhua, additional, Futreal, Andrew, additional, Klopp, Ann, additional, and Colbert, Lauren, additional

Published
2022
Full Text
View/download PDF

25. Feasibility of a novel non-invasive swab technique for serial whole-exome sequencing of cervical tumors during chemoradiation therapy

Author

Bronk, Julianna K., primary, Kapadia, Chiraag, additional, Wu, Xiaogang, additional, Chapman, Bhavana V., additional, Wang, Rui, additional, Karpinets, Tatiana V., additional, Song, Xingzhi, additional, Futreal, Andrew M., additional, Zhang, Jianhua, additional, Klopp, Ann H., additional, and Colbert, Lauren E., additional

Published
2022
Full Text
View/download PDF

26. NEIM-06 COMBINING CLINICAL VARIABLES AND RADIOMIC FEATURES TO HELP DISTINGUISH RADIATION NECROSIS FROM TUMOR IN PATIENTS WITH MELANOMA BRAIN METASTASES TREATED WITH RADIOSURGERY

Author

Tran, Benjamin, primary, Buszek, Samantha, additional, Mitchell, Drew, additional, Long, James, additional, Elliott, Andrew, additional, Langshaw, Holly, additional, Erickson, Lily, additional, Farhat, Maguy, additional, Bronk, Julianna, additional, Ferguson, Sherise, additional, and Chung, Caroline, additional

Published
2022
Full Text
View/download PDF

27. NEIM-05 FEASIBILITY OF NAVIGATED TRANSCRANIAL MAGNETIC STIMULATION (NTMS) BASED DIFFUSION TENSOR IMAGING (DTI) TRACTOGRAPHY OF MOTOR PATHWAYS IN PATIENTS UNDERGOING STEREOTACTIC RADIOSURGERY: A CROSS-SECTIONAL DOSIMETRIC AND PATIENT OUTCOMES ANALYSIS

Author

Bronk, Julianna, primary, Muir, Matthew, additional, Michener, Hayley, additional, Calbat, Courtney, additional, Mackin, Dennis, additional, Mitchell, Drew, additional, Train, Benjamin, additional, Farhat, Maguy, additional, Elliot, Andrew, additional, Prabhu, Sujit, additional, Prinsloo, Sarah, additional, and Chung, Caroline, additional

Published
2022
Full Text
View/download PDF

29. Cancer-associated Lactobacillus iners are genetically distinct and associated with chemoradiation resistance in cervical cancer

Author

Colbert, Lauren E., primary, Karpinets, Tatiana, additional, El Alam, Molly B., additional, Lynn, Erica J., additional, Sammouri, Julie, additional, Lo, David, additional, Elnaggar, Jacob H, additional, Wang, Rui, additional, Harris, Timothy A, additional, Yoshida-Court, Kyoko, additional, Tomasic, Katarina, additional, Bronk, Julianna K., additional, Yanamandra, Ananta V., additional, Olvera, Adilene V., additional, Carlin, Lily G., additional, Sims, Travis, additional, Delgado Medrano, Andrea Y., additional, Solley, Travis, additional, Eifel, Patricia J., additional, Jhingran, Anuja, additional, Joyner, Melissa, additional, Lin, Lilie, additional, Ramondetta, Lois M., additional, Futreal, Andrew M., additional, Schmeler, Kathleen M., additional, Mathew, Geena, additional, Dorta-Estremera, Stephanie, additional, Zhang, Jianhua, additional, Wu, Xiaogang, additional, Ajami, Nadim J., additional, Taniguchi, Cullen, additional, Petrosino, Joseph F., additional, Wargo, Jennifer, additional, Sastry, K. Jagannadha, additional, Okhuysen, Pablo C., additional, and Klopp, Ann H., additional

Published
2022
Full Text
View/download PDF

31. Expansion of Candidate HPV-Specific T Cells in the Tumor Microenvironment during Chemoradiotherapy Is Prognostic in HPV16+ Cancers

Author

Colbert, Lauren E., primary, El, Molly B., additional, Lynn, Erica J., additional, Bronk, Julianna, additional, Karpinets, Tatiana V., additional, Wu, Xiaogang, additional, Chapman, Bhavana V., additional, Sims, Travis T., additional, Lin, Daniel, additional, Kouzy, Ramez, additional, Sammouri, Julie, additional, Biegert, Greyson, additional, Delgado Medrano, Andrea Y., additional, Olvera, Adilene, additional, Sastry, K. Jagannadha, additional, Eifel, Patricia J., additional, Jhingran, Anuja, additional, Lin, Lilie, additional, Ramondetta, Lois M., additional, Futreal, Andrew P., additional, Jazaeri, Amir A., additional, Schmeler, Kathleen M., additional, Yue, Jingyan, additional, Mitra, Aparna, additional, Yoshida-Court, Kyoko, additional, Wargo, Jennifer A., additional, Solley, Travis N., additional, Hegde, Venkatesh, additional, Nookala, Sita S., additional, Yanamandra, Ananta V., additional, Dorta-Estremera, Stephanie, additional, Mathew, Geena, additional, Kavukuntla, Rohit, additional, Papso, Cassidy, additional, Ahmed-Kaddar, Mustapha, additional, Kim, Minsoo, additional, Zhang, Jianhua, additional, Reuben, Alexandre, additional, Holliday, Emma B., additional, Minsky, Bruce D., additional, Koong, Albert C., additional, Koay, Eugene J., additional, Das, Prajnan, additional, Taniguchi, Cullen M., additional, and Klopp, Ann, additional

Published
2022
Full Text
View/download PDF

32. Tumor-Resident&nbsp; Lactobacillus iners&nbsp;Confers Chemoradiation Resistance in Cervical Cancer Patients Through Acquired Metabolic Functions

Author

Colbert, Lauren, primary, El Alam, Molly B., additional, Karpinets, Tatiana, additional, Lynn, Erica J., additional, Lo, David, additional, Wang, Rui, additional, Harris, Timothy A., additional, Elnaggar, Jacob, additional, Yoshida-Court, Kyoko, additional, Tomasic, Katarina, additional, Bronk, Julianna K., additional, Sammouri, Julie, additional, Yanamandra, Ananta V., additional, Olvera, Adilene V., additional, Carlin, Lily G., additional, Sims, Travis, additional, Delgado Medrano, Andrea Y., additional, Lin, Daniel, additional, Abana, Chike O., additional, Eifel, Patricia J., additional, Jhingran, Anuja, additional, Joyner, Melissa, additional, Lin, Lilie, additional, Ramondetta, Lois M., additional, Futreal, Andrew M., additional, Schmeler, Kathleen, additional, Mathew, Geena, additional, Dorta-Estremera, Stephanie, additional, Zhang, Jianhua, additional, Wu, Xiaogang, additional, Ajami, Nadim J., additional, Taniguchi, Cullen M., additional, Petrosino, Joseph F., additional, Wargo, Jennifer, additional, Sastry, K. Jagannadha, additional, Okhuysen, Pablo, additional, and Klopp, Ann H., additional

Published
2022
Full Text
View/download PDF

33. Interleukin-11 receptor is a candidate target for ligand-directed therapy in lung cancer: analysis of clinical samples and BMTP-11 pre-clinical activity

Author

Cardó-Vila, Marina, Marchiò, Serena, Sato, Masanori, Staquicini, Fernanda I., Smith, Tracey L., Bronk, Julianna K., Yin, Guosheng, Zurita, Amado J., Sun, Menghong, Behrens, Carmen, Sidman, Richard L., Lee, J. Jack, Hong, Waun K., Wistuba, Ignacio I., Arap, Wadih, and Pasqualini, Renata

Subjects
Animals, Antineoplastic Agents, Apoptosis, Biomarkers, Tumor, Carcinoma, Cell Line, Tumor, Cell Proliferation, Cell Survival, Female, Flow Cytometry, Humans, Immunohistochemistry, Lung Neoplasms, Male, Mice, Mice, Inbred BALB C, Mice, Nude, Peptides, Receptors, Interleukin-11, Retrospective Studies, Tissue Array Analysis, Xenograft Model Antitumor Assays, 2734, Nude, Cell Line, Receptors, Inbred BALB C, Tumor, Regular Article, Interleukin-11, Biomarkers
Abstract

We previously isolated an IL-11–mimic motif (CGRRAGGSC) that binds to IL-11 receptor (IL-11R) in vitro and accumulates in IL-11R–expressing tumors in vivo. This synthetic peptide ligand was used as a tumor-targeting moiety in the rational design of BMTP-11, which is a drug candidate in clinical trials. Here, we investigated the specificity and accessibility of IL-11R as a target and the efficacy of BMTP-11 as a ligand-targeted drug in lung cancer. We observed high IL-11R expression levels in a large cohort of patients (n = 368). In matching surgical specimens (i.e., paired tumors and nonmalignant tissues), the cytoplasmic levels of IL-11R in tumor areas were significantly higher than in nonmalignant tissues (n = 36; P = 0.003). Notably, marked overexpression of IL-11R was observed in both tumor epithelial and vascular endothelial cell membranes (n = 301; P

Published
2016

36. Mimicking large spot-scanning radiation fields for proton FLASH preclinical studies with a robotic motion platform.

Author

Guan F, Jiang D, Wang X, Yang M, Iga K, Li Y, Bronk L, Bronk J, Wang L, Guo Y, Sahoo N, Grosshans DR, Koong AC, Zhu XR, and Mohan R

Abstract

Previously, a synchrotron-based horizontal proton beamline (87.2 MeV) was successfully commissioned to deliver radiation doses in FLASH and conventional dose rate modes to small fields and volumes. In this study, we developed a strategy to increase the effective radiation field size using a custom robotic motion platform to automatically shift the positions of biological samples. The beam was first broadened with a thin tungsten scatterer and shaped by customized brass collimators for irradiating cell/organoid cultures in 96-well plates (a 7-mm-diameter circle) or for irradiating mice (1-cm 2 square). Motion patterns of the robotic platform were written in G-code, with 9-mm spot spacing used for the 96-well plates and 10.6-mm spacing for the mice. The accuracy of target positioning was verified with a self-leveling laser system. The dose delivered in the experimental conditions was validated with EBT-XD film attached to the 96-well plate or the back of the mouse. Our film-measured dose profiles matched Monte Carlo calculations well (1D gamma pass rate >95%). The FLASH dose rates were 113.7 Gy/s for cell/organoid irradiation and 191.3 Gy/s for mouse irradiation. These promising results indicate that this robotic platform can be used to effectively increase the field size for preclinical experiments with proton FLASH., Competing Interests: Conflict of Interest Kiminori Iga is currently employed by Hitachi Ltd. Other authors declare no conflicts of interest.

Published
2024

37. Expansion of Candidate HPV-Specific T Cells in the Tumor Microenvironment during Chemoradiotherapy Is Prognostic in HPV16 + Cancers.

Author

Colbert LE, El MB, Lynn EJ, Bronk J, Karpinets TV, Wu X, Chapman BV, Sims TT, Lin D, Kouzy R, Sammouri J, Biegert G, Delgado Medrano AY, Olvera A, Sastry KJ, Eifel PJ, Jhingran A, Lin L, Ramondetta LM, Futreal AP, Jazaeri AA, Schmeler KM, Yue J, Mitra A, Yoshida-Court K, Wargo JA, Solley TN, Hegde V, Nookala SS, Yanamandra AV, Dorta-Estremera S, Mathew G, Kavukuntla R, Papso C, Ahmed-Kaddar M, Kim M, Zhang J, Reuben A, Holliday EB, Minsky BD, Koong AC, Koay EJ, Das P, Taniguchi CM, and Klopp A

Subjects
Chemoradiotherapy, Female, Human papillomavirus 16, Humans, Papillomavirus E7 Proteins, Prognosis, Repressor Proteins, T-Lymphocytes, Tumor Microenvironment, Oncogene Proteins, Viral, Papillomavirus Infections, Uterine Cervical Neoplasms
Abstract

Human papillomavirus (HPV) infection causes 600,000 new cancers worldwide each year. HPV-related cancers express the oncogenic proteins E6 and E7, which could serve as tumor-specific antigens. It is not known whether immunity to E6 and E7 evolves during chemoradiotherapy or affects survival. Using T cells from 2 HPV16 + patients, we conducted functional T-cell assays to identify candidate HPV-specific T cells and common T-cell receptor motifs, which we then analyzed across 86 patients with HPV-related cancers. The HPV-specific clones and E7-related T-cell receptor motifs expanded in the tumor microenvironment over the course of treatment, whereas non-HPV-specific T cells did not. In HPV16 + patients, improved recurrence-free survival was associated with HPV-responsive T-cell expansion during chemoradiotherapy., (©2022 American Association for Cancer Research.)

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results