1. Metagenomic next-generation sequencing assistance in identifying Mycobacterium iranicum pulmonary infection: A case report.
- Author
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Xu L, Wang L, Song Y, and Tong L
- Subjects
- Humans, Female, Aged, Anti-Bacterial Agents therapeutic use, Nontuberculous Mycobacteria genetics, Nontuberculous Mycobacteria isolation & purification, Nontuberculous Mycobacteria drug effects, Tomography, X-Ray Computed, Moxifloxacin therapeutic use, Doxycycline therapeutic use, High-Throughput Nucleotide Sequencing, Bronchoalveolar Lavage Fluid microbiology, Metagenomics methods, Mycobacterium Infections, Nontuberculous microbiology, Mycobacterium Infections, Nontuberculous drug therapy, Mycobacterium Infections, Nontuberculous diagnosis
- Abstract
Nontuberculous mycobacteria (NTM) are important opportunistic pathogens in humans, mostly affecting the lungs, and potentially causing progressive disease in individuals with underlying diseases. The prevalence of NTM infections is increasing worldwide. However, Mycobacterium iranicum (M. iranicum) infections are less common. Here we report a 65-year-old female who developed pneumonia caused by Mycobacterium iranicum, which was detected in bronchoalveolar lavage fluid (BALF) through metagenomic next-generation sequencing (mNGS). The patient was treated with moxifloxacin, doxycycline, and sulfamethoxazole/trimethoprim. Symptoms were relieved and lung abnormalities were shown to be partially absorbed on the follow-up chest computed tomography (CT) scans. As we know, this is the first case of Mycobacterium iranicum pulmonary infection identified by mNGS in BALF., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Inc. All rights reserved.)
- Published
- 2024
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