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3. Percutaneous Application of Sulfanilamide in Animals and Men

Author

Zondek, Bernhard, Bromberg, Yehuda M., and Shapiro, Benjamin

Abstract

Sulfanilamide if applied percutaneously is resorbed by the skin of rabbits and men. (a) The concentration of sulfanilamide in the blood of rabbits following its percutaneous administration is as high as that obtained after its oral administration, but inferior to the concentration following subcutaneous or intramuscular injections. (b) The blood concentration of sulfanilamide in men following its percutaneous administration is lower than that after oral administration, but vomiting is much more rare and less severe.The percutaneous use of sulfanilamide may serve as an auxiliary method of chemotherapentic treatment in certain cases.

Published
1942
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