Search

Your search keyword '"Brombach, Carolin"' showing total 11 results
Start Over Author "Brombach, Carolin"
11 results on '"Brombach, Carolin"'

3. A 2-Hydroxybutyrate- mediated feedback loop regulates muscular fatigue

Author

Wadsworth, Brennan J, primary, Leiwe, Marina, additional, Minogue, Eleanor A, additional, Cunha, Pedro P, additional, Engman, Viktor, additional, Brombach, Carolin, additional, Asvestis, Christos, additional, Sah-Teli, Shiv K, additional, Marklund, Emilia, additional, Koivunen, Peppi, additional, Ruas, Jorge L, additional, Rundqvist, Helene, additional, Lanner, Johanna T, additional, and Johnson, Randall S, additional

Published
2023
Full Text
View/download PDF

4. Oxygen levels at the time of activation determine T cell persistence and immunotherapeutic efficacy

Author

Cunha, Pedro P, primary, Minogue, Eleanor, additional, Krause, Lena CM, additional, Hess, Rita M, additional, Bargiela, David, additional, Wadsworth, Brennan J, additional, Barbieri, Laura, additional, Brombach, Carolin, additional, Foskolou, Iosifina P, additional, Bogeski, Ivan, additional, Velica, Pedro, additional, and Johnson, Randall S, additional

Published
2023
Full Text
View/download PDF

5. Supplementary Figures and Tables S1 and S3 from Infiltration of Tumors Is Regulated by T cell–Intrinsic Nitric Oxide Synthesis

Author

Cunha, Pedro P., primary, Bargiela, David, primary, Minogue, Eleanor, primary, Krause, Lena C.M., primary, Barbieri, Laura, primary, Brombach, Carolin, primary, Gojkovic, Milos, primary, Marklund, Emilia, primary, Pietsch, Sandra, primary, Foskolou, Iosifina, primary, Branco, Cristina M., primary, Veliça, Pedro, primary, and Johnson, Randall S., primary

Published
2023
Full Text
View/download PDF

6. Supplementary Table S2 from Infiltration of Tumors Is Regulated by T cell–Intrinsic Nitric Oxide Synthesis

Author

Cunha, Pedro P., primary, Bargiela, David, primary, Minogue, Eleanor, primary, Krause, Lena C.M., primary, Barbieri, Laura, primary, Brombach, Carolin, primary, Gojkovic, Milos, primary, Marklund, Emilia, primary, Pietsch, Sandra, primary, Foskolou, Iosifina, primary, Branco, Cristina M., primary, Veliça, Pedro, primary, and Johnson, Randall S., primary

Published
2023
Full Text
View/download PDF

7. Data from Infiltration of Tumors Is Regulated by T cell–Intrinsic Nitric Oxide Synthesis

Author

Cunha, Pedro P., primary, Bargiela, David, primary, Minogue, Eleanor, primary, Krause, Lena C.M., primary, Barbieri, Laura, primary, Brombach, Carolin, primary, Gojkovic, Milos, primary, Marklund, Emilia, primary, Pietsch, Sandra, primary, Foskolou, Iosifina, primary, Branco, Cristina M., primary, Veliça, Pedro, primary, and Johnson, Randall S., primary

Published
2023
Full Text
View/download PDF

8. Infiltration of Tumors Is Regulated by T cell–Intrinsic Nitric Oxide Synthesis

Author

Cunha, Pedro P., primary, Bargiela, David, additional, Minogue, Eleanor, additional, Krause, Lena C.M., additional, Barbieri, Laura, additional, Brombach, Carolin, additional, Gojkovic, Milos, additional, Marklund, Emilia, additional, Pietsch, Sandra, additional, Foskolou, Iosifina, additional, Branco, Cristina M., additional, Veliça, Pedro, additional, and Johnson, Randall S., additional

Published
2022
Full Text
View/download PDF

9. Oxygen levels at the time of activation determine T cell persistence and immunotherapeutic efficacy

Author

Cunha, Pedro P., primary, Minogue, Eleanor, additional, Krause, Lena C. M., additional, Hess, Rita M., additional, Bargiela, David, additional, Wadsworth, Brennan J., additional, Barbieri, Laura, additional, Brombach, Carolin, additional, Foskolou, Iosifina P., additional, Bogeski, Ivan, additional, Veliça, Pedro, additional, and Johnson, Randall S., additional

Published
2022
Full Text
View/download PDF

10. Infiltration of Tumors Is Regulated by T cell-Intrinsic Nitric Oxide Synthesis

Author

Pedro P. Cunha, David Bargiela, Eleanor Minogue, Lena C.M. Krause, Laura Barbieri, Carolin Brombach, Milos Gojkovic, Emilia Marklund, Sandra Pietsch, Iosifina Foskolou, Cristina M. Branco, Pedro Veliça, Randall S. Johnson, Cunha, Pedro P [0000-0002-3814-6289], Bargiela, David [0000-0003-1953-6916], Minogue, Eleanor [0000-0002-4418-445X], Krause, Lena CM [0000-0003-3375-2850], Barbieri, Laura [0000-0001-9932-2664], Brombach, Carolin [0000-0002-7775-8915], Gojkovic, Milos [0000-0001-6451-9192], Marklund, Emilia [0000-0002-3131-8690], Pietsch, Sandra [0000-0001-6398-253X], Foskolou, Iosifina [0000-0003-1874-6356], Branco, Cristina M [0000-0001-6953-4922], Veliça, Pedro [0000-0002-0557-8544], Johnson, Randall S [0000-0002-4084-6639], and Apollo - University of Cambridge Repository

Subjects
Mice, Knockout, Cancer Research, Mice, Neoplasms, Immunology, Animals, Humans, Nitric Oxide Synthase Type II, CD8-Positive T-Lymphocytes, Nitric Oxide
Abstract

Nitric oxide (NO) is a signaling molecule produced by NO synthases (NOS1–3) to control processes such as neurotransmission, vascular permeability, and immune function. Although myeloid cell–derived NO has been shown to suppress T-cell responses, the role of NO synthesis in T cells themselves is not well understood. Here, we showed that significant amounts of NO were synthesized in human and murine CD8+ T cells following activation. Tumor growth was significantly accelerated in a T cell–specific, Nos2-null mouse model. Genetic deletion of Nos2 expression in murine T cells altered effector differentiation, reduced tumor infiltration, and inhibited recall responses and adoptive cell transfer function. These data show that endogenous NO production plays a critical role in T cell–mediated tumor immunity.

Published
2023

11. Infiltration of Tumors Is Regulated by T cell-Intrinsic Nitric Oxide Synthesis.

Author

Cunha PP, Bargiela D, Minogue E, Krause LCM, Barbieri L, Brombach C, Gojkovic M, Marklund E, Pietsch S, Foskolou I, Branco CM, Veliça P, and Johnson RS

Subjects
Animals, Mice, Humans, Nitric Oxide Synthase Type II genetics, Mice, Knockout, CD8-Positive T-Lymphocytes, Nitric Oxide, Neoplasms genetics
Abstract

Nitric oxide (NO) is a signaling molecule produced by NO synthases (NOS1-3) to control processes such as neurotransmission, vascular permeability, and immune function. Although myeloid cell-derived NO has been shown to suppress T-cell responses, the role of NO synthesis in T cells themselves is not well understood. Here, we showed that significant amounts of NO were synthesized in human and murine CD8+ T cells following activation. Tumor growth was significantly accelerated in a T cell-specific, Nos2-null mouse model. Genetic deletion of Nos2 expression in murine T cells altered effector differentiation, reduced tumor infiltration, and inhibited recall responses and adoptive cell transfer function. These data show that endogenous NO production plays a critical role in T cell-mediated tumor immunity., (©2022 The Authors; Published by the American Association for Cancer Research.)

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results