210 results on '"Broly, Hervé"'
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2. Continuous bleed recycling significantly increases recombinant protein production yield in perfusion cell cultures
3. The Formidable Challenge of Controlling High Mannose-Type N-Glycans in Therapeutic mAbs
4. A two-step procedure for the design of perfusion bioreactors
5. Monitoring of antibody glycosylation pattern based on microarray MALDI-TOF mass spectrometry
6. Perfusion cell culture for the production of conjugated recombinant fusion proteins reduces clipping and quality heterogeneity compared to batch-mode processes
7. Intensification of large-scale cell culture processes
8. Proteomic analysis of micro-scale bioreactors as scale-down model for a mAb producing CHO industrial fed-batch platform
9. Experimental and CFD physical characterization of animal cell bioreactors: From micro- to production scale
10. Glycosylation flux analysis reveals dynamic changes of intracellular glycosylation flux distribution in Chinese hamster ovary fed-batch cultures
11. Cell culture media supplemented with raffinose reproducibly enhances high mannose glycan formation
12. Effects of the COVID-19 pandemic: new approaches for accelerated delivery of gene to first-in-human CMC data for recombinant proteins
13. High-throughput profiling of nucleotides and nucleotide sugars to evaluate their impact on antibody N-glycosylation
14. Determination of the maximum operating range of hydrodynamic stress in mammalian cell culture
15. Pilot-scale verification of maximum tolerable hydrodynamic stress for mammalian cell culture
16. Lactate metabolism shift in CHO cell culture: the role of mitochondrial oxidative activity
17. Enhanced process understanding and multivariate prediction of the relationship between cell culture process and monoclonal antibody quality
18. Application of Quality by Design to the characterization of the cell culture process of an Fc-Fusion protein
19. Transfer of continuous manufacturing process principles for mAb production in a GMP environment: A step in the transition from batch to continuous
20. Robust factor selection in early cell culture process development for the production of a biosimilar monoclonal antibody
21. Rapid cGMP manufacturing of COVID‐19 monoclonal antibody using stable CHO cell pools
22. Screening and assessment of performance and molecule quality attributes of industrial cell lines across different fed-batch systems
23. Fingerprint detection and process prediction by multivariate analysis of fed-batch monoclonal antibody cell culture data
24. Tailoring recombinant protein quality by rational media design
25. Cell culture medium improvement by rigorous shuffling of components using media blending
26. Modulation of mAb quality attributes using microliter scale fed-batch cultures
27. Quality by Design Applied to a Fc-Fusion Protein: A Case Study
28. A high-throughput media design approach for high performance mammalian fed-batch cultures
29. High expression of the aspartate–glutamate carrier Aralar1 favors lactate consumption in CHO cell culture
30. Effect of hydrocortisone on the production and glycosylation of an Fc-fusion protein in CHO cell cultures
31. Quality attributes of recombinant therapeutic proteins: An assessment of impact on safety and efficacy as part of a quality by design development approach
32. Reduction of medium consumption in perfusion mammalian cell cultures using a perfusion rate equivalent concentrated nutrient feed
33. Cell culture process metabolomics together with multivariate data analysis tools opens new routes for bioprocess development and glycosylation prediction
34. Rapid cGMP manufacturing of COVID‐19 monoclonal antibody using stable CHO cell pools.
35. Process‐wide control and automation of an integrated continuous manufacturing platform for antibodies
36. Understanding mAb aggregation during low pH viral inactivation and subsequent neutralization
37. Mechanistic reconstruction of glycoprotein secretion through monitoring of intracellular N-glycan processing
38. No interactions between heparin and atacicept, an antagonist of B cell survival cytokines
39. A new flow cell and chemometric protocol for implementing in‐line Raman spectroscopy in chromatography
40. Process design and development of a mammalian cell perfusion culture in shake‐tube and benchtop bioreactors
41. Experimental Evaluation of the Impact of Intrinsic Process Parameters on the Performance of a Continuous Chromatographic Polishing Unit (MCSGP)
42. Semi-continuous scale-down models for clone and operating parameter screening in perfusion bioreactors
43. Perfusion mammalian cell culture for recombinant protein manufacturing – A critical review
44. Generation of site‐distinct N‐glycan variants for in vitro bioactivity testing
45. Understanding mAb aggregation during low pH viral inactivation and subsequent neutralization.
46. Development of a shake tube‐based scale‐down model for perfusion cultures
47. Improved Performance in Mammalian Cell Perfusion Cultures by Growth Inhibition
48. Sequential Multivariate Cell Culture Modeling at Multiple Scales Supports Systematic Shaping of a Monoclonal Antibody Toward a Quality Target
49. Implementation of Plate Imaging for Demonstration of Monoclonality in Biologics Manufacturing Development
50. Modulation and modeling of monoclonal antibody N‐linked glycosylation in mammalian cell perfusion reactors
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