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1. The Role of Non-Invasive Multimodality Imaging in Chronic Coronary Syndrome: Anatomical and Functional Pathways

Author

Bergamaschi, L, Pavon, A, Angeli, F, Tuttolomondo, D, Belmonte, M, Armillotta, M, Sansonetti, A, Foa, A, Paolisso, P, Baggiano, A, Mushtaq, S, De Zan, G, Carriero, S, Cramer, M, Teske, A, Broekhuizen, L, van der Bilt, I, Muscogiuri, G, Sironi, S, Leo, L, Gaibazzi, N, Lovato, L, Pontone, G, Pizzi, C, Guglielmo, M, Bergamaschi L., Pavon A. G., Angeli F., Tuttolomondo D., Belmonte M., Armillotta M., Sansonetti A., Foa A., Paolisso P., Baggiano A., Mushtaq S., De Zan G., Carriero S., Cramer M. -J., Teske A. J., Broekhuizen L., van der Bilt I., Muscogiuri G., Sironi S., Leo L. A., Gaibazzi N., Lovato L., Pontone G., Pizzi C., Guglielmo M., Bergamaschi, L, Pavon, A, Angeli, F, Tuttolomondo, D, Belmonte, M, Armillotta, M, Sansonetti, A, Foa, A, Paolisso, P, Baggiano, A, Mushtaq, S, De Zan, G, Carriero, S, Cramer, M, Teske, A, Broekhuizen, L, van der Bilt, I, Muscogiuri, G, Sironi, S, Leo, L, Gaibazzi, N, Lovato, L, Pontone, G, Pizzi, C, Guglielmo, M, Bergamaschi L., Pavon A. G., Angeli F., Tuttolomondo D., Belmonte M., Armillotta M., Sansonetti A., Foa A., Paolisso P., Baggiano A., Mushtaq S., De Zan G., Carriero S., Cramer M. -J., Teske A. J., Broekhuizen L., van der Bilt I., Muscogiuri G., Sironi S., Leo L. A., Gaibazzi N., Lovato L., Pontone G., Pizzi C., and Guglielmo M.

Abstract

Coronary artery disease (CAD) is one of the major causes of mortality and morbidity worldwide, with a high socioeconomic impact. Currently, various guidelines and recommendations have been published about chronic coronary syndromes (CCS). According to the recent European Society of Cardiology guidelines on chronic coronary syndrome, a multimodal imaging approach is strongly recommended in the evaluation of patients with suspected CAD. Today, in the current practice, non-invasive imaging methods can assess coronary anatomy through coronary computed tomography angiography (CCTA) and/or inducible myocardial ischemia through functional stress testing (stress echocardiography, cardiac magnetic resonance imaging, single photon emission computed tomography—SPECT, or positron emission tomography—PET). However, recent trials (ISCHEMIA and REVIVED) have cast doubt on the previous conception of the management of patients with CCS, and nowadays it is essential to understand the limitations and strengths of each imaging method and, specifically, when to choose a functional approach focused on the ischemia versus a coronary anatomy-based one. Finally, the concept of a pathophysiology-driven treatment of these patients emerged as an important goal of multimodal imaging, integrating ‘anatomical’ and ‘functional’ information. The present review aims to provide an overview of non-invasive imaging modalities for the comprehensive management of CCS patients.

Published
2023

2. Literacy in Indigenous Communities. Research Series.

Author

Pacific Resources for Education and Learning, Honolulu, HI. and van Broekhuizen, L. David

Abstract

In this research synthesis, notions of literacy from a variety of inclusive rather than exclusive perspectives are presented. Notions of national literacies, mother-tongue literacies, multiple literacies, and bi-literacies are explored. Information and research pertaining to threatened languages, language shift, and language loss is presented, because of the obvious significance these phenomena hold for indigenous communities throughout the world. Furthermore, a number of issues regarding first language literacy instruction are explored, using examples from all over the world. Included in this discussion is status of language, acquisition planning, and corpus planning. Finally, the uses of literacy in a variety of communities and contexts are examined. It is concluded that choices regarding literacy made by indigenous communities are highly divergent. In instances where communities have a true voice, where the choice is not heavily influenced by socioeconomically dominant groups, mother tongues are embraced. For the vast majority of indigenous communities, where such free choices are not available, the language of economics often triumphs over the language of hearth and home. Contains 40 references. (KFT)

Published
2000

3. Teacher Diversity: Implications for Professional Development. Research Series.

Author

Pacific Resources for Education and Learning, Honolulu, HI., van Broekhuizen, L. David, and Dougherty, Barbara

Abstract

This research synthesis provides insight into issues related to teacher diversity and faculty development. It begins with a review of the literature on models of professional development and the characteristics of effective professional development identified by research, with the knowledge that little, if any, research has addressed professional development with diverse teachers. The next section discusses factors to consider when planning professional development (school or institution structures, design of professional development experiences, time factors, and teacher change factors). The third section focuses on diversity and culture, including the characteristics of deep culture, and discusses the American dream as it applies to a diverse and inclusive United States. Finally, the publication puts forth implications for professional development in light of the expanding diversity of U.S. educators. It examines the role of culture in current professional development models and the cultural and contextual variables that are key to providing effective professional development in diverse settings for diverse teachers. Nine steps for developing effective faculty development for diverse teachers are described. (Contains 37 references.) (SM)

Published
1999

4. Aortic regurgitation: A multimodality approach

Author

Siani, A, Perone, F, Costantini, P, Rodolfi, S, Muscogiuri, G, Sironi, S, Carriero, S, Pavon, A, van der Bilt, I, van Rosendael, P, Broekhuizen, L, Teske, A, Cramer, M, Guglielmo, M, Siani A., Perone F., Costantini P., Rodolfi S., Muscogiuri G., Sironi S., Carriero S., Pavon A. G., van der Bilt I., van Rosendael P., Broekhuizen L., Teske A., Cramer M. J., Guglielmo M., Siani, A, Perone, F, Costantini, P, Rodolfi, S, Muscogiuri, G, Sironi, S, Carriero, S, Pavon, A, van der Bilt, I, van Rosendael, P, Broekhuizen, L, Teske, A, Cramer, M, Guglielmo, M, Siani A., Perone F., Costantini P., Rodolfi S., Muscogiuri G., Sironi S., Carriero S., Pavon A. G., van der Bilt I., van Rosendael P., Broekhuizen L., Teske A., Cramer M. J., and Guglielmo M.

Abstract

Aortic regurgitation (AR) is a common valvular pathology. Multimodality noninvasive cardiovascular imaging is routinely used to assess the mechanism of AR, degree, and its hemodynamic impact on the cardiovascular system. Collecting this information is crucial in establishing the prognosis and in guiding patient management and follow-up. While echocardiography remains the primary test to assess AR, a comprehensive assessment of this valvulopathy can be obtained by combining the information from different techniques. This state-of-the-art review is intended to provide an update ed overview of the applications, strengths, and limits of transthoracic echocardiography, cardiac magnetic resonance, and cardiac computed tomography in patients with AR.

Published
2022

6. 2015 ESC Guidelines for the management of infective endocarditis: The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by the European Association for Cardiothoracic Surgery (EACTS) and the European Association of Nuclear Medicine (EANM)

Author

Habib G., Lancellotti P., Antunes M. J., Bongiorni M. G., Casalta J. -P., Del Zotti F., Dulgheru R., El Khoury G., Erba P. A., Iung B., Miro J. M., Mulder B. J., Plonska-Gosciniak E., Price S., Roos-Hesselink J., Snygg-Martin U., Thuny F., Mas P. T., Vilacosta I., Zamorano J. L., Erol C., Nihoyannopoulos P., Aboyans V., Agewall S., Athanassopoulos G., Aytekin S., Benzer W., Bueno H., Broekhuizen L., Carerj S., Cosyns B., De Backer J., De Bonis M., Dimopoulos K., Donal E., Drexel H., Flachskampf F. A., Hall R., Halvorsen S., Hoen B., Kirchhof P., Lainscak M., Leite-Moreira A. F., Lip G. Y. H., Mestres C. A., Piepoli M. F., Punjabi P. P., Rapezzi C., Rosenhek R., Siebens K., Tamargo J., Walker D. M., Habib, G., Lancellotti, P., Antunes, M. J., Bongiorni, M. G., Casalta, J. -P., Del Zotti, F., Dulgheru, R., El Khoury, G., Erba, P. A., Iung, B., Miro, J. M., Mulder, B. J., Plonska-Gosciniak, E., Price, S., Roos-Hesselink, J., Snygg-Martin, U., Thuny, F., Mas, P. T., Vilacosta, I., Zamorano, J. L., Erol, C., Nihoyannopoulos, P., Aboyans, V., Agewall, S., Athanassopoulos, G., Aytekin, S., Benzer, W., Bueno, H., Broekhuizen, L., Carerj, S., Cosyns, B., De Backer, J., De Bonis, M., Dimopoulos, K., Donal, E., Drexel, H., Flachskampf, F. A., Hall, R., Halvorsen, S., Hoen, B., Kirchhof, P., Lainscak, M., Leite-Moreira, A. F., Lip, G. Y. H., Mestres, C. A., Piepoli, M. F., Punjabi, P. P., Rapezzi, C., Rosenhek, R., Siebens, K., Tamargo, J., Walker, D. M., Habib, G, Lancellotti, P, Antunes, M, Bongiorni, M, Casalta, J, Del Zotti, F, Dulgheru, R, El Khoury, G, Erba, P, Iung, B, Miro, J, Mulder, B, Plonska-Gosciniak, E, Price, S, Roos-Hesselink, J, Snygg-Martin, U, Thuny, F, Mas, P, Vilacosta, I, Zamorano, J, Erol, C, Nihoyannopoulos, P, Aboyans, V, Agewall, S, Athanassopoulos, G, Aytekin, S, Benzer, W, Bueno, H, Broekhuizen, L, Carerj, S, Cosyns, B, De Backer, J, De Bonis, M, Dimopoulos, K, Donal, E, Drexel, H, Flachskampf, F, Hall, R, Halvorsen, S, Hoen, B, Kirchhof, P, Lainscak, M, Leite-Moreira, A, Lip, G, Mestres, C, Piepoli, M, Punjabi, P, Rapezzi, C, Rosenhek, R, Siebens, K, Tamargo, J, and Walker, D

Subjects
Algorithm, Heart Valve Disease, Decision Tree, Decision Trees, Heart Valve Diseases, Humans, Endocarditis, Bacterial, Prognosis, Algorithms, Human
Published
2016

7. 2015 ESC Guidelines for the management of infective endocarditis: The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by the European Association for Cardiothoracic Surgery (EACTS) and the European Association of Nuclear Medicine (EANM) [Linee guida ESC 2015 per il trattamento dell'endocardite infettiva: Task Force per il Trattamento dell'Endocardite Infettiva della Società Europea di Cardiologia (ESC): Con il patrocinio dell'Associazione Europea di Chirurgia Cardiotoracica (EACTS) e dell'Associazione Europea di Medicina Nucleare (EANM)]

Author

Habib, G, Lancellotti, P, Antunes, M, Bongiorni, M, Casalta, J, Del Zotti, F, Dulgheru, R, El Khoury, G, Erba, P, Iung, B, Miro, J, Mulder, B, Plonska-Gosciniak, E, Price, S, Roos-Hesselink, J, Snygg-Martin, U, Thuny, F, Mas, P, Vilacosta, I, Zamorano, J, Erol, C, Nihoyannopoulos, P, Aboyans, V, Agewall, S, Athanassopoulos, G, Aytekin, S, Benzer, W, Bueno, H, Broekhuizen, L, Carerj, S, Cosyns, B, De Backer, J, De Bonis, M, Dimopoulos, K, Donal, E, Drexel, H, Flachskampf, F, Hall, R, Halvorsen, S, Hoen, B, Kirchhof, P, Lainscak, M, Leite-Moreira, A, Lip, G, Mestres, C, Piepoli, M, Punjabi, P, Rapezzi, C, Rosenhek, R, Siebens, K, Tamargo, J, Walker, D, Habib G., Lancellotti P., Antunes M. J., Bongiorni M. G., Casalta J. -P., Del Zotti F., Dulgheru R., El Khoury G., Erba P. A., Iung B., Miro J. M., Mulder B. J., Plonska-Gosciniak E., Price S., Roos-Hesselink J., Snygg-Martin U., Thuny F., Mas P. T., Vilacosta I., Zamorano J. L., Erol C., Nihoyannopoulos P., Aboyans V., Agewall S., Athanassopoulos G., Aytekin S., Benzer W., Bueno H., Broekhuizen L., Carerj S., Cosyns B., De Backer J., De Bonis M., Dimopoulos K., Donal E., Drexel H., Flachskampf F. A., Hall R., Halvorsen S., Hoen B., Kirchhof P., Lainscak M., Leite-Moreira A. F., Lip G. Y. H., Mestres C. A., Piepoli M. F., Punjabi P. P., Rapezzi C., Rosenhek R., Siebens K., Tamargo J., Walker D. M., Habib, G, Lancellotti, P, Antunes, M, Bongiorni, M, Casalta, J, Del Zotti, F, Dulgheru, R, El Khoury, G, Erba, P, Iung, B, Miro, J, Mulder, B, Plonska-Gosciniak, E, Price, S, Roos-Hesselink, J, Snygg-Martin, U, Thuny, F, Mas, P, Vilacosta, I, Zamorano, J, Erol, C, Nihoyannopoulos, P, Aboyans, V, Agewall, S, Athanassopoulos, G, Aytekin, S, Benzer, W, Bueno, H, Broekhuizen, L, Carerj, S, Cosyns, B, De Backer, J, De Bonis, M, Dimopoulos, K, Donal, E, Drexel, H, Flachskampf, F, Hall, R, Halvorsen, S, Hoen, B, Kirchhof, P, Lainscak, M, Leite-Moreira, A, Lip, G, Mestres, C, Piepoli, M, Punjabi, P, Rapezzi, C, Rosenhek, R, Siebens, K, Tamargo, J, Walker, D, Habib G., Lancellotti P., Antunes M. J., Bongiorni M. G., Casalta J. -P., Del Zotti F., Dulgheru R., El Khoury G., Erba P. A., Iung B., Miro J. M., Mulder B. J., Plonska-Gosciniak E., Price S., Roos-Hesselink J., Snygg-Martin U., Thuny F., Mas P. T., Vilacosta I., Zamorano J. L., Erol C., Nihoyannopoulos P., Aboyans V., Agewall S., Athanassopoulos G., Aytekin S., Benzer W., Bueno H., Broekhuizen L., Carerj S., Cosyns B., De Backer J., De Bonis M., Dimopoulos K., Donal E., Drexel H., Flachskampf F. A., Hall R., Halvorsen S., Hoen B., Kirchhof P., Lainscak M., Leite-Moreira A. F., Lip G. Y. H., Mestres C. A., Piepoli M. F., Punjabi P. P., Rapezzi C., Rosenhek R., Siebens K., Tamargo J., and Walker D. M.

Published
2016

8. 2015 ESC Guidelines for the management of infective endocarditis: The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM)

Author

Habib, G, Lancellotti, P, Antunes, Mj, Bongiorni, Mg, Casalta, Jp, Del Zotti, F, Dulgheru, R, El Khoury, G, Erba, Pa, Iung, B, Miro, Jm, Mulder, Bj, Plonska-Gosciniak, E, Price, S, Roos-Hesselink, J, Snygg-Martin, U, Thuny, F, Tornos Mas, P, Vilacosta, I, Zamorano, Jl, Document, Reviewers., Erol, Ç, Nihoyannopoulos, P, Aboyans, V, Agewall, S, Athanassopoulos, G, Aytekin, S, Benzer, W, Bueno, H, Broekhuizen, L, Carerj, S, Cosyns, B, De Backer, J, De Bonis, M, Dimopoulos, K, Donal, E, Drexel, H, Flachskampf, Fa, Hall, R, Halvorsen, S, Hoen, B, Kirchhof, P, Lainscak, M, Leite-Moreira, Af, Lip, Gy, Mestres, Ca, Piepoli, Mf, Punjabi, Pp, Rapezzi, C, Rosenhek, R, Siebens, K, Tamargo, J, Walker, Dm, Habib G, Lancellotti P, Antunes MJ, Bongiorni MG, Casalta JP, Del Zotti F, Dulgheru R, El Khoury G, Erba PA, Iung B, Miro JM, Mulder BJ, Plonska-Gosciniak E, Price S, Roos-Hesselink J, Snygg-Martin U, Thuny F, Tornos Mas P, Vilacosta I, Zamorano JL, Document Reviewers., Erol Ç, Nihoyannopoulos P, Aboyans V, Agewall S, Athanassopoulos G, Aytekin S, Benzer W, Bueno H, Broekhuizen L, Carerj S, Cosyns B, De Backer J, De Bonis M, Dimopoulos K, Donal E, Drexel H, Flachskampf FA, Hall R, Halvorsen S, Hoen B, Kirchhof P, Lainscak M, Leite-Moreira AF, Lip GY, Mestres CA, Piepoli MF, Punjabi PP, Rapezzi C, Rosenhek R, Siebens K, Tamargo J, Walker DM, DIPARTIMENTO DI MEDICINA SPECIALISTICA, DIAGNOSTICA E SPERIMENTALE, Facolta' di MEDICINA e CHIRURGIA, AREA MIN. 06 - Scienze mediche, Habib, G, Lancellotti, P, Antunes, Mj, Bongiorni, Mg, Casalta, Jp, Del Zotti, F, Dulgheru, R, El Khoury, G, Erba, Pa, Iung, B, Miro, Jm, Mulder, Bj, Plonska gosciniak, E, Price, S, Roos hesselink, J, Snygg martin, U, Thuny, F, Mas, Pt, Vilacosta, I, Zamorano, Jl, Erol, Ç, Nihoyannopoulos, P, Aboyans, V, Agewall, S, Athanassopoulos, G, Aytekin, S, Benzer, W, Bueno, H, Broekhuizen, L, Carerj, S, Cosyns, B, De Backer, J, DE BONIS, Michele, Dimopoulos, K, Donal, E, Drexel, H, Flachskampf, Fa, Hall, R, Halvorsen, S, Hoen, B, Kirchhof, P, Lainscak, M, Leite moreira, Af, Lip, Gy, Mestres, Ca, Piepoli, Mf, Punjabi, Pp, Rapezzi, C, Rosenhek, R, Siebens, K, Tamargo, J, and Walker, Dm

Subjects
Microbiological Techniques, Heart disease, Embolism, Heart Valve Diseases, Cardiac device, Cardiac imaging, Cardiac surgery, Congenital heart disease, Echocardiography, Endocarditis, Guidelines, Infection, Nuclear imaging, Pregnancy, Prevention, Prognosis, Prophylaxis, Prosthetic heart valves, Valve disease, Guideline, Arrhythmias, Cardiovascular, Congenital, Postoperative Complications, Recurrence, Risk Factors, Neoplasms, Ambulatory Care, Non-Infective, Pericarditis, Endocarditi, Musculoskeletal Diseases, Prophylaxi, Heart Defects, Cross Infection, Acute Kidney Injury, Operative, Anti-Bacterial Agents, Myocarditis, Prosthetic heart valve, Endocarditis, Non-Infective, Infective endocarditis, Cardiology, Female, Cardiology and Cardiovascular Medicine, Infected, Cardiac, Heart Defects, Congenital, Diagnostic Imaging, medicine.medical_specialty, Prosthesis-Related Infections, Critical Care, Prognosi, Pregnancy Complications, Cardiovascular, Risk Assessment, NO, Aneurysm, Infected, Antibiotic Prophylaxis, Arrhythmias, Cardiac, Clinical Laboratory Techniques, Dentistry, Operative, Fibrinolytic Agents, Heart Failure, Humans, Long-Term Care, Nervous System Diseases, Patient Care Team, Splenic Diseases, Thoracic Surgical Procedures, Internal medicine, medicine, business.industry, medicine.disease, Aneurysm, Pregnancy Complications, Heart failure, Dentistry, business, Fibrinolytic agent
Abstract

none 53 si The disclosure forms of all experts involved in the development of these guidelines are available on the ESC website http://www.escardio.org/guidelines. Representing the European Association of Nuclear Medicine (EANM); Representing the European Society of Clinical Microbiology and Infectious Diseases (ESCMID); and Representing the European Association for Cardio-Thoracic Surgery (EACTS). Guidelines for the management of infective endocarditis Habib G; Lancellotti P; Antunes MJ; Bongiorni MG; Casalta JP; Del Zotti F; Dulgheru R; El Khoury G; Erba PA; Iung B; Miro JM; Mulder BJ; Plonska-Gosciniak E; Price S; Roos-Hesselink J; Snygg-Martin U; Thuny F; Tornos Mas P; Vilacosta I; Zamorano JL; Document Reviewers.; Erol Ç; Nihoyannopoulos P; Aboyans V; Agewall S; Athanassopoulos G; Aytekin S; Benzer W; Bueno H; Broekhuizen L; Carerj S; Cosyns B; De Backer J; De Bonis M; Dimopoulos K; Donal E; Drexel H; Flachskampf FA; Hall R; Halvorsen S; Hoen B; Kirchhof P; Lainscak M; Leite-Moreira AF; Lip GY; Mestres CA; Piepoli MF; Punjabi PP; Rapezzi C; Rosenhek R; Siebens K; Tamargo J; Walker DM Habib G; Lancellotti P; Antunes MJ; Bongiorni MG; Casalta JP; Del Zotti F; Dulgheru R; El Khoury G; Erba PA; Iung B; Miro JM; Mulder BJ; Plonska-Gosciniak E; Price S; Roos-Hesselink J; Snygg-Martin U; Thuny F; Tornos Mas P; Vilacosta I; Zamorano JL; Document Reviewers.; Erol Ç; Nihoyannopoulos P; Aboyans V; Agewall S; Athanassopoulos G; Aytekin S; Benzer W; Bueno H; Broekhuizen L; Carerj S; Cosyns B; De Backer J; De Bonis M; Dimopoulos K; Donal E; Drexel H; Flachskampf FA; Hall R; Halvorsen S; Hoen B; Kirchhof P; Lainscak M; Leite-Moreira AF; Lip GY; Mestres CA; Piepoli MF; Punjabi PP; Rapezzi C; Rosenhek R; Siebens K; Tamargo J; Walker DM

Published
2015

9. 2015 ESC Guidelines for the management of infective endocarditis

Author

Habib, G, Lancellotti, P, Antunes, M, Bongiorni, M, Casalta, J, Del Zotti, F, Dulgheru, R, El Khoury, G, Erba, P, Iung, B, Mirob, J, Mulder, B, Plonska-Gosciniak, E, Price, S, Roos-Hesselink, J, Snygg-Martin, U, Thuny, F, Mas, P, Vilacosta, I, Zamorano, J, Erol, C, Nihoyannopoulos, P, Aboyans, V, Agewall, S, Athanassopoulos, G, Aytekin, S, Benzer, W, Bueno, H, Broekhuizen, L, Carerj, S, Cosyns, B, De Backer, J, De Bonis, M, Dimopoulos, K, Donal, E, Drexel, H, Flachskampf, F, Hall, R, Halvorsen, S, Hoenb, B, Kirchhof, P, Lainscak, M, Leite-Moreira, A, Lip, G, Mestresc, C, Piepoli, M, Punjabi, P, Rapezzi, C, Rosenhek, R, Siebens, K, Tamargo, J, Walker, D, Habib G., Lancellotti P., Antunes M. J., Bongiorni M. G., Casalta J. -P., Del Zotti F., Dulgheru R., El Khoury G., Erba P. A., Iung B., Mirob J. M., Mulder B. J., Plonska-Gosciniak E., Price S., Roos-Hesselink J., Snygg-Martin U., Thuny F., Mas P. T., Vilacosta I., Zamorano J. L., Erol C., Nihoyannopoulos P., Aboyans V., Agewall S., Athanassopoulos G., Aytekin S., Benzer W., Bueno H., Broekhuizen L., Carerj S., Cosyns B., De Backer J., De Bonis M., Dimopoulos K., Donal E., Drexel H., Flachskampf F. A., Hall R., Halvorsen S., Hoenb B., Kirchhof P., Lainscak M., Leite-Moreira A. F., Lip G. Y. H., Mestresc C. A., Piepoli M. F., Punjabi P. P., Rapezzi C., Rosenhek R., Siebens K., Tamargo J., Walker D. M., Habib, G, Lancellotti, P, Antunes, M, Bongiorni, M, Casalta, J, Del Zotti, F, Dulgheru, R, El Khoury, G, Erba, P, Iung, B, Mirob, J, Mulder, B, Plonska-Gosciniak, E, Price, S, Roos-Hesselink, J, Snygg-Martin, U, Thuny, F, Mas, P, Vilacosta, I, Zamorano, J, Erol, C, Nihoyannopoulos, P, Aboyans, V, Agewall, S, Athanassopoulos, G, Aytekin, S, Benzer, W, Bueno, H, Broekhuizen, L, Carerj, S, Cosyns, B, De Backer, J, De Bonis, M, Dimopoulos, K, Donal, E, Drexel, H, Flachskampf, F, Hall, R, Halvorsen, S, Hoenb, B, Kirchhof, P, Lainscak, M, Leite-Moreira, A, Lip, G, Mestresc, C, Piepoli, M, Punjabi, P, Rapezzi, C, Rosenhek, R, Siebens, K, Tamargo, J, Walker, D, Habib G., Lancellotti P., Antunes M. J., Bongiorni M. G., Casalta J. -P., Del Zotti F., Dulgheru R., El Khoury G., Erba P. A., Iung B., Mirob J. M., Mulder B. J., Plonska-Gosciniak E., Price S., Roos-Hesselink J., Snygg-Martin U., Thuny F., Mas P. T., Vilacosta I., Zamorano J. L., Erol C., Nihoyannopoulos P., Aboyans V., Agewall S., Athanassopoulos G., Aytekin S., Benzer W., Bueno H., Broekhuizen L., Carerj S., Cosyns B., De Backer J., De Bonis M., Dimopoulos K., Donal E., Drexel H., Flachskampf F. A., Hall R., Halvorsen S., Hoenb B., Kirchhof P., Lainscak M., Leite-Moreira A. F., Lip G. Y. H., Mestresc C. A., Piepoli M. F., Punjabi P. P., Rapezzi C., Rosenhek R., Siebens K., Tamargo J., and Walker D. M.

Published
2015

10. Dispersivity-saturation relationship in a lab-scale soil column

Author

Broekhuizen, L. van, Raoof, Amir (Thesis Advisor), Broekhuizen, L. van, and Raoof, Amir (Thesis Advisor)

Abstract

Solute transport through porous media is affected by variations in pore-flow velocity which cause meandering of flow paths. This causes the solute to spread in both longitudinal and transversal directions. This spreading is defined as hydrodynamic dispersion in the advection-dispersion equation (ADE). Dispersivity is a property of a porous medium that is linearly related to the hydrodynamic dispersion through pore-water velocity. In this study the relation between dispersivity and soil water content is investigated by conducting solute displacement experiments in a soil column under saturated and unsaturated conditions. A pulse of a CaCl2 tracer solute was injected into a soil column and the concentration was measured at three depths along the column using electrical conductivity sensors. The resulting breakthrough curves (BTCs) were analyzed to determine the dispersivity, using the solution of the ADE by the CXTFIT2 software code. Results show the dispersivity values that were an order of magnitude larger for the unsaturated soils than for the saturated soils. This demonstrates the large dependency of dispersivity on soil water content. However, the results did not allow a clear relation to be determined. This is caused by a lack of data points and a lack of a mobile-immobile transport model, which could probably describe solute transport in unsaturated soils more accurately than the ADE.

Published
2017

16. Guía ESC 2015 sobre el tratamiento de la endocarditis infecciosa

Author

Stefan Agewall, Isidre Vilacosta, Raluca Elena Dulgheru, Edyta Plonska-Gosciniak, Manuel J. Antunes, Sigrun Halvorsen, Franck Thuny, Bernard Cosyns, Ulrika Snygg-Martin, Scipione Carerj, Kaat Siebens, Çetin Erol, José Luis Zamorano, Petros Nihoyannopoulos, Werner Benzer, Carlos A. Mestres, Mitja Lainscak, Raphael Rosenhek, Erwan Donal, Gregory Y.H. Lip, Massimo F Piepoli, Barbara J. Mulder, Konstantinos Dimopoulos, Paulus Kirchhof, Maria Grazia Bongiorni, David M. Walker, Paola Anna Erba, Pilar Tornos Mas, Michele De Bonis, Heinz Drexel, Frank A. Flachskampf, Jolien W. Roos-Hesselink, George Athanassopoulos, Bruno Hoen, Saide Aytekin, Victor Aboyans, Adelino F. Leite-Moreira, José M. Miró, Héctor Bueno, Julie De Backer, Roger Hall, Bernard Iung, Jean Paul Casalta, Prakash P Punjabi, Claudio Rapezzi, Susanna Price, Lidewij Broekhuizen, Gebrine El Khoury, Francesco Del Zotti, Patrizio Lancellotti, Juan Tamargo, Gilbert Habib, Habib, G., Lancellotti, P., Antunes, M. J., Bongiorni, M. G., Casalta, J. -P., Zotti, F. D., Dulgheru, R., Khoury, G. E., Erba, P. A., Iung, B., Miro, J. M., Mulder, B. J., Plonska-Gosciniak, E., Price, S., Roos-Hesselink, J., Snygg-Martin, U., Thuny, F., Mas, P. T., Vilacosta, I., Zamorano, J. L., Erol, C., Nihoyannopoulos, P., Aboyans, V., Agewall, S., Athanassopoulos, G., Aytekin, S., Benzer, W., Bueno, H., Broekhuizen, L., Carerj, S., Cosyns, B., De Backer, J., De Bonis, M., Dimopoulos, K., Donal, E., Drexel, H., Flachskampf, F. A., Hall, R., Halvorsen, S., Hoen, B., Kirchhof, P., Lainscak, M., Leite-Moreira, A. F., Lip, G. Y. H., Mestres, C. A., Piepoli, M. F., Punjabi, P. P., Rapezzi, C., Rosenhek, R., Siebens, K., Tamargo, J., Walker, D. M., Habib, Gilbert, Lancellotti, Patrizio, Antunes, Manuel J., Bongiorni, Maria Grazia, Casalta, Jean-Paul, Zotti, Francesco Del, Dulgheru, Raluca, Khoury, Gebrine El, Erba, Paola Anna, Iung, Bernard, Miró, Jose M., Mulder, Barbara J., Plonska-Gosciniak, Edyta, Price, Susanna, Roos-Hesselink, Jolien, Snygg-Martin, Ulrika, Thuny, Franck, Mas, Pilar Torno, Vilacosta, Isidre, Zamorano, José Lui, Erol, Çetin, Nihoyannopoulos, Petro, Aboyans, Victor, Agewall, Stefan, Athanassopoulos, George, Aytekin, Saide, Benzer, Werner, Bueno, Héctor, Broekhuizen, Lidewij, Carerj, Scipione, Cosyns, Bernard, De Backer, Julie, De Bonis, Michele, Dimopoulos, Konstantino, Donal, Erwan, Drexel, Heinz, Flachskampf, Frank Arnold, Hall, Roger, Halvorsen, Sigrun, Hoen, Bruno, Kirchhof, Paulu, Lainscak, Mitja, Leite-Moreira, Adelino F., Lip, Gregory Y.H., Mestres, Carlos A., Piepoli, Massimo F., Punjabi, Prakash P., Rapezzi, Claudio, Rosenhek, Raphael, Siebens, Kaat, Tamargo, Juan, and Walker, David M.

Subjects
business.industry, practice guideline, Endocarditis. Imagen cardiaca. Valvulopatía. Ecocardiografía. Pronóstico. Guías de práctica clínica. Infección. Imagen de cardiología nuclear. Cirugía cardiaca. Dispositivo cardiaco. Válvulas cardiacas protésicas. Cardiopatía congénita. Embarazo. Profilaxis. Prevención, Cardiology and Cardiovascular Medicine, bacterial endocarditis, Settore MED/11 - Malattie dell'Apparato Cardiovascolare, 030204 cardiovascular system & hematology, NO, 03 medical and health sciences, 0302 clinical medicine, Medicine, 030212 general & internal medicine, business, Humanities
Abstract

Las Guías de Práctica Clínica (GPC) tienen como objetivo reunir y evaluar toda la evidencia relevante disponible durante el proceso deelaboración sobre un tema particular para ayudar a los médicos a seleccionar la mejor estrategia posible de tratamiento para un paciente en particular, que sufre una enfermedad determinada, teniendo en cuenta no solo el resultado final, sino también sopesando los riesgos y los beneficios de un procedimiento diagnóstico o terapéutico concreto. Las GPC y las recomendaciones deben ayudar a los profesionales de la salud en la toma de decisiones clínicas en su ejercicio diario. No obstante, la decisión final sobre un paciente concreto la debe tomar el médico responsable de su cuidado, en consulta con el propio paciente o, cuando proceda, con la persona responsable de sus cuidados. En los últimos años, la Sociedad Europea de Cardiología (ESC), además de otras sociedades y organizaciones científicas, ha publicado un gran número de GPC. Debido al impacto de las GPC, se han establecido criterios de calidad para su elaboración de forma que todas las decisiones se presenten de modo claro y transparente al usuario. Se puede encontrar las recomendaciones de la ESC para la elaboración y publicación de GPC en la sección de guías de la página web de la ESC (http://www.escardio.org/Guidelines-&-Education/Clinical-Practice- Guidelines/Guidelines-development/Writing-ESC-Guidelines). Las GPC de la ESC representan la postura oficial de la ESC sobre un tema particular y se actualizan con regularidad.

Published
2016

17. 2015 ESC Guidelines for the management of infective endocarditis

Author

Habib, Gilbert, Lancellotti, Patrizio, Antunes, Manuel J., Bongiorni, Maria Grazia, Casalta, Jean-Paul, del Zotti, Francesco, Dulgheru, Raluca, El Khoury, Gebrine, Erba, Paola Anna, Iung, Bernard, Miro, Jose M., Mulder, Barbara J., Plonska-Gosciniak, Edyta, Price, Susanna, Roos-Hesselink, Jolien, Snygg-Martin, Ulrika, Thuny, Franck, Tornos Mas, Pilar, Vilacosta, Isidre, Zamorano, Jose Luis, Erol, Çetin, Nihoyannopoulos, Petros, Aboyans, Victor, Agewall, Stefan, Athanassopoulos, George, Aytekin, Saide, Benzer, Werner, Bueno, Héctor, Broekhuizen, Lidewij, Carerj, Scipione, Cosyns, Bernard, de Backer, Julie, de Bonis, Michele, Dimopoulos, Konstantinos, Donal, Erwan, Drexel, Heinz, Flachskampf, Frank Arnold, Hall, Roger, Halvorsen, Sigrun, Hoen, Bruno, Kirchhof, Paulus, Lainscak, Mitja, Leite-Moreira, Adelino F., Lip, Gregory Y. H., Mestres, Carlos A., Piepoli, Massimo F., Punjabi, Prakash P., Rapezzi, Claudio, Rosenhek, Raphael, Siebens, Kaat, Tamargo, Juan, Walker, David M., Habib, G, Lancellotti, P, Antunes, M, Bongiorni, M, Casalta, J, Del Zotti, F, Dulgheru, R, El Khoury, G, Erba, P, Iung, B, Mirob, J, Mulder, B, Plonska-Gosciniak, E, Price, S, Roos-Hesselink, J, Snygg-Martin, U, Thuny, F, Mas, P, Vilacosta, I, Zamorano, J, Erol, C, Nihoyannopoulos, P, Aboyans, V, Agewall, S, Athanassopoulos, G, Aytekin, S, Benzer, W, Bueno, H, Broekhuizen, L, Carerj, S, Cosyns, B, De Backer, J, De Bonis, M, Dimopoulos, K, Donal, E, Drexel, H, Flachskampf, F, Hall, R, Halvorsen, S, Hoenb, B, Kirchhof, P, Lainscak, M, Leite-Moreira, A, Lip, G, Mestresc, C, Piepoli, M, Punjabi, P, Rapezzi, C, Rosenhek, R, Siebens, K, Tamargo, J, Walker, D, ACS - Amsterdam Cardiovascular Sciences, and Cardiology

Subjects
Microbiological Techniques, Embolism, Heart Valve Diseases, Guideline, Arrhythmias, Cardiovascular, Congenital, Postoperative Complications, Pregnancy, Recurrence, Risk Factors, Neoplasms, Ambulatory Care, Non-Infective, Pericarditis, Endocarditi, Musculoskeletal Diseases, Prophylaxi, Heart Defects, Cross Infection, Endocarditis, Thoracic Surgery, Cardiac surgery, Acute Kidney Injury, Prognosis, Operative, Anti-Bacterial Agents, Myocarditis, Prosthetic heart valve, Echocardiography, Female, Infection, Cardiology and Cardiovascular Medicine, Nuclear imaging, Infected, Cardiac, Diagnostic Imaging, Prosthesis-Related Infections, Critical Care, Prognosi, Guidelines, Prosthetic heart valves, Cardiac device, Risk Assessment, Valve disease, Cardiac imaging, Congenital heart disease, Prevention, Prophylaxis, Aneurysm, Infected, Antibiotic Prophylaxis, Arrhythmias, Cardiac, Clinical Laboratory Techniques, Dentistry, Operative, Endocarditis, Non-Infective, Fibrinolytic Agents, Heart Defects, Congenital, Heart Failure, Humans, Long-Term Care, Nervous System Diseases, Patient Care Team, Pregnancy Complications, Cardiovascular, Splenic Diseases, Thoracic Surgical Procedures, Endocarditis, Bacterial, Aneurysm, Pregnancy Complications, Dentistry
Abstract

Take-home message of the full 2015 ESC Guidelines, also endorsed by the European Association for Cardio-Thoracic Surgery, European Association of Nuclear Medicine, and European Society of Clinical Microbiology and Infectious Diseases.

Published
2015

18. Cardiac magnetic resonance in advanced heart failure.

Author

Coraducci F, De Zan G, Fedele D, Costantini P, Guaricci AI, Pavon AG, Teske A, Cramer MJ, Broekhuizen L, Van Osch D, Danad I, Velthuis B, Suchá D, van der Bilt I, Pizzi C, Russo AD, Oerlemans M, van Laake LW, van der Harst P, and Guglielmo M

Subjects
Humans, Magnetic Resonance Imaging, Cine methods, Heart Failure physiopathology, Heart Failure diagnosis
Abstract

Heart failure (HF) is a chronic and progressive disease that often progresses to an advanced stage where conventional therapy is insufficient to relieve patients' symptoms. Despite the availability of advanced therapies such as mechanical circulatory support or heart transplantation, the complexity of defining advanced HF, which requires multiple parameters and multimodality assessment, often leads to delays in referral to dedicated specialists with the result of a worsening prognosis. In this review, we aim to explore the role of cardiac magnetic resonance (CMR) in advanced HF by showing how CMR is useful at every step in managing these patients: from diagnosis to prognostic stratification, hemodynamic evaluation, follow-up and advanced therapies such as heart transplantation. The technical challenges of scanning advanced HF patients, which often require troubleshooting of intracardiac devices and dedicated scans, will be also discussed., (© 2024 The Author(s). Echocardiography published by Wiley Periodicals LLC.)

Published
2024
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19. The Role of Non-Invasive Multimodality Imaging in Chronic Coronary Syndrome: Anatomical and Functional Pathways.

Author

Bergamaschi L, Pavon AG, Angeli F, Tuttolomondo D, Belmonte M, Armillotta M, Sansonetti A, Foà A, Paolisso P, Baggiano A, Mushtaq S, De Zan G, Carriero S, Cramer MJ, Teske AJ, Broekhuizen L, van der Bilt I, Muscogiuri G, Sironi S, Leo LA, Gaibazzi N, Lovato L, Pontone G, Pizzi C, and Guglielmo M

Abstract

Coronary artery disease (CAD) is one of the major causes of mortality and morbidity worldwide, with a high socioeconomic impact. Currently, various guidelines and recommendations have been published about chronic coronary syndromes (CCS). According to the recent European Society of Cardiology guidelines on chronic coronary syndrome, a multimodal imaging approach is strongly recommended in the evaluation of patients with suspected CAD. Today, in the current practice, non-invasive imaging methods can assess coronary anatomy through coronary computed tomography angiography (CCTA) and/or inducible myocardial ischemia through functional stress testing (stress echocardiography, cardiac magnetic resonance imaging, single photon emission computed tomography-SPECT, or positron emission tomography-PET). However, recent trials (ISCHEMIA and REVIVED) have cast doubt on the previous conception of the management of patients with CCS, and nowadays it is essential to understand the limitations and strengths of each imaging method and, specifically, when to choose a functional approach focused on the ischemia versus a coronary anatomy-based one. Finally, the concept of a pathophysiology-driven treatment of these patients emerged as an important goal of multimodal imaging, integrating 'anatomical' and 'functional' information. The present review aims to provide an overview of non-invasive imaging modalities for the comprehensive management of CCS patients.

Published
2023
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20. Aortic regurgitation: A multimodality approach.

Author

Siani A, Perone F, Costantini P, Rodolfi S, Muscogiuri G, Sironi S, Carriero S, Pavon AG, van der Bilt I, van Rosendael P, Broekhuizen L, Teske A, Cramer MJ, and Guglielmo M

Subjects
Echocardiography, Humans, Magnetic Resonance Imaging, Multimodal Imaging methods, Aortic Valve Insufficiency diagnostic imaging, Heart Valve Diseases
Abstract

Aortic regurgitation (AR) is a common valvular pathology. Multimodality noninvasive cardiovascular imaging is routinely used to assess the mechanism of AR, degree, and its hemodynamic impact on the cardiovascular system. Collecting this information is crucial in establishing the prognosis and in guiding patient management and follow-up. While echocardiography remains the primary test to assess AR, a comprehensive assessment of this valvulopathy can be obtained by combining the information from different techniques. This state-of-the-art review is intended to provide an update ed overview of the applications, strengths, and limits of transthoracic echocardiography, cardiac magnetic resonance, and cardiac computed tomography in patients with AR., (© 2022 The Authors. Journal of Clinical Ultrasound published by Wiley Periodicals LLC.)

Published
2022
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21. Incidental chest radiographic findings in adult patients with acute cough.

Author

van Vugt S, Broekhuizen L, Zuithoff N, de Jong P, Butler C, Hood K, Coenen S, Goossens H, Little P, Almirall J, Blasi F, Chlabicz S, Davies M, Godycki-Cwirko M, Hupkova H, Kersnik J, Mierzecki A, Mölstad S, Moore M, Schaberg T, De Sutter A, Torres A, Touboul P, and Verheij T

Subjects
Acute Disease, Adolescent, Adult, Aged, Aged, 80 and over, Cross-Sectional Studies, Europe, Female, Humans, Male, Middle Aged, Prevalence, Primary Health Care, Radiography, Thoracic, Young Adult, Cough diagnostic imaging, Incidental Findings, Lung diagnostic imaging
Abstract

Purpose: Imaging may produce unexpected or incidental findings with consequences for patients and ordering of future investigations. Chest radiography in patients with acute cough is among the most common reasons for imaging in primary care, but data on associated incidental findings are lacking. We set out to describe the type and prevalence of incidental chest radiography findings in primary care patients with acute cough., Methods: We report on data from a cross-sectional study in 16 European primary care networks on 3,105 patients with acute cough, all of whom were undergoing chest radiography as part of a research study workup. Apart from assessment for specified signs of pneumonia and acute bronchitis, local radiologists were asked to evaluate any additional finding on the radiographs. For the 2,823 participants with good-quality chest radiographs, these findings were categorized according to clinical relevance based on previous research evidence and analyzed for type and prevalence by network, sex, age, and smoking status., Results: Incidental findings were reported in 19% of all participants, and ranged from 0% to 25% by primary care network, with the network being an independent contributor (P <.001). Of all participants 3% had clinically relevant incidental findings. Suspected nodules and shadows were reported in 1.8%. Incidental findings were more common is older participants and smokers (P <. 001)., Conclusions: Clinically relevant incidental findings on chest radiographs in primary care adult patients with acute cough are uncommon, and prevalence varies by setting.

Published
2012
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22. Airway obstruction and bronchodilator responsiveness in adults with acute cough.

Author

Vugt Sv, Broekhuizen L, Zuithoff N, Butler C, Hood K, Coenen S, Goossens H, Little P, Almirall J, Blasi F, Chlabicz S, Davies M, Godycki-Cwirko M, Hupkova H, Kersnik J, Moore M, Schaberg T, De Sutter A, Torres A, and Verheij T

Subjects
Acute Disease, Adult, Cough etiology, Cross-Sectional Studies, Europe epidemiology, Humans, Middle Aged, Prevalence, Primary Health Care, Treatment Outcome, Airway Obstruction epidemiology, Asthma diagnosis, Bronchodilator Agents therapeutic use, Cough drug therapy, Pulmonary Disease, Chronic Obstructive diagnosis, Spirometry methods
Abstract

Purpose: We sought to determine the prevalence of airway obstruction and bronchodilator responsiveness in adults consulting for acute cough in primary care., Methods: Family physicians recruited 3,105 adult patients with acute cough (28 days or shorter) attending primary care practices in 12 European countries. After exclusion of patients with preexisting physician-diagnosed asthma or chronic obstructive pulmonary disease (COPD), we undertook complete case analysis of spirometry results (n = 1,947) 28 to 35 days after inclusion. Bronchodilator responsiveness was diagnosed if there were recurrent complaints of wheezing, cough, or dyspnea and an increase of the forced expiratory volume in 1 second (FEV(1)) of 12% or more after bronchodilation. Airway obstruction was diagnosed according to 2 thresholds for the (postbronchodilator) ratio of FEV(1) to forced vital capacity (FEV(1):FVC): less than 0.7 and less than the lower limit of normal., Results: There were 240 participants who showed bronchodilator responsiveness (12%), 193 (10%) had a FEV(1)/FVC ratio of less than 0.7, and 126 (6%) had a ratio of less than the lower limit of normal. Spearman's correlation between the 2 definitions of obstruction was 0.71 (P <.001), with discordance most pronounced among those younger than 30 years and in older participants., Conclusions: Both bronchodilator responsiveness and persistent airway obstruction are common in adults without established asthma or COPD who consult for acute cough in primary care, which suggests a high risk of undiagnosed asthma and COPD. Different accepted methods to define airway obstruction detected different numbers of patients, especially at the extremes of age. As both conditions benefit from appropriate and timely interventions, clinicians should be aware and responsive to potential underdiagnosis.

Published
2012
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23. The incidence and significance of micrometastases in lymph nodes of patients with ductal carcinoma in situ and T1a carcinoma of the breast.

Author

Broekhuizen LN, Wijsman JH, Peterse JL, and Rutgers EJ

Subjects
Adenocarcinoma pathology, Adenocarcinoma secondary, Adult, Aged, Aged, 80 and over, Axilla, Carcinoma pathology, Carcinoma, Ductal, Breast pathology, Carcinoma, Lobular pathology, Carcinoma, Lobular secondary, Female, Follow-Up Studies, Humans, Immunohistochemistry, Lymph Node Excision, Lymph Nodes pathology, Middle Aged, Neoplasm Invasiveness, Neoplasm Staging, Neoplastic Cells, Circulating pathology, Retrospective Studies, Sentinel Lymph Node Biopsy, Survival Rate, Breast Neoplasms pathology, Carcinoma secondary, Carcinoma in Situ pathology, Carcinoma, Ductal, Breast secondary, Lymphatic Metastasis pathology
Abstract

Aim: To report the incidence and predictive value of positive axillary nodes in ductal carcinoma in situ (DCIS) and T1a carcinoma of the breast., Methods: Cases from The Netherlands Cancer Institute were used to determine the incidence of lymph-node metastases. All consecutive patients with primary breast cancer that were treated between 1989 and 1998 and who had undergone axillary dissection were selected. Patients were identified with pure DCIS (n = 71), DCIS with small invasion (n = 12), invasive ductal/lobular carcinoma (IDC/ILC) < or =5 mm (n = 18) or tubular carcinoma < or =10 mm (n = 17). All archived lymph nodes of these patients were re-evaluated using immunohistochemistry (IHC)., Results: In DCIS the incidence increased from 1.4% with routine staining to 11% with IHC. For DCIS with small invasion it was 0 vs 27%, respectively. In IDC/ILC sized 2-5 mm the incidence rose from 6 to 12% and in tubular carcinoma < or =10 mm from 0 to 12%. All but one of the immunohistochemically detected metastases were isolated tumour cells (n = 9) or small (micro)metastases (n = 4). Maximally two nodes per patient were affected. None of the patients with positive lymph nodes died during follow-up (mean 102 months)., Conclusions: Survival of our patients appeared not to be influenced by the finding of micrometastases in the lymph nodes by IHC. Immunohistochemistry of the sentinel node seems not contributive to further treatment in these patients.

Published
2006
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24. Stereological study of stage 34 chicken hearts with looping disturbances after retinoic acid treatment: disturbed growth of myocardium and atrioventricular cushion tissue.

Author

Bouman HG, Broekhuizen LA, Baasten AM, Gittenberger-de Groot AC, and Wenink AC

Subjects
Animals, Cardiac Volume drug effects, Chick Embryo, Endocardial Cushion Defects chemically induced, Heart Ventricles drug effects, Endocardial Cushion Defects pathology, Heart drug effects, Heart embryology, Tretinoin pharmacology
Abstract

Background: In a previous study retinoic acid treatment of chicken hearts has resulted in a spectrum of looping disturbances. Because of a decrease in contraction force of these hearts, the myocardial volume was hypothesized to be altered. Because retinoic acid has been suggested to influence endocardial cushion volumes, these were estimated as well., Methods: The previously studied hearts were used for estimating the absolute volumes of the atrial and ventricular myocardium and of the endocardial cushions by means of Cavalieri's principle. To measure the surface density of the trabeculations according to the isector method, we used retinoic acid treated hearts, which were perfusion fixed and in which the sections were isotropic uniform random. The volumes and surface densities found in the three morphologically distinguished groups, i.e., intact septum, isolated ventricular septal defect and double outlet right ventricle, were compared with those in shams., Results: A significant volume decrease was found in the right ventricular free wall myocardium of the double outlet right ventricle. No significant differences were found in the surface densities of the trabeculae. The volume of the atrioventricular cushion tissue in the double outlet right ventricle hearts was significantly increased. The morphological spectrum observed previously was also expressed in the right ventricular myocardial volume, which appeared to decrease from the least to the most malformed hearts, and in the volume of the atrioventricular cushion tissue, which appeared to increase., Conclusions: Several studies have shown pathology in myocardial and cushion tissue after retinoic acid treatment. In this study we have found a decreased growth of the right ventricular myocardium and an increased growth of the atrioventricular cushion tissue. We suggest that the previously found looping disturbance causes changed hemodynamics, as reported elsewhere, and that these result in changes in growth. We cannot exclude a direct effect of retinoic acid on the myocardium, which has to explain the looping disturbance.

Published
1997
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