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1. Smoking-induced gene expression changes in the bronchial airway are reflected in nasal and buccal epithelium

Author

Zhang Xiaohui, Dumas Yves-Martine, Liu Gang, Steiling Katrina, Gustafson Adam M, Shah Vishal, Zeskind Julie, Schembri Frank, Sridhar Sriram, Brody Jerome S, Lenburg Marc E, and Spira Avrum

Subjects
Biotechnology, TP248.13-248.65, Genetics, QH426-470
Abstract

Abstract Background Cigarette smoking is a leading cause of preventable death and a significant cause of lung cancer and chronic obstructive pulmonary disease. Prior studies have demonstrated that smoking creates a field of molecular injury throughout the airway epithelium exposed to cigarette smoke. We have previously characterized gene expression in the bronchial epithelium of never smokers and identified the gene expression changes that occur in the mainstem bronchus in response to smoking. In this study, we explored relationships in whole-genome gene expression between extrathorcic (buccal and nasal) and intrathoracic (bronchial) epithelium in healthy current and never smokers. Results Using genes that have been previously defined as being expressed in the bronchial airway of never smokers (the "normal airway transcriptome"), we found that bronchial and nasal epithelium from non-smokers were most similar in gene expression when compared to other epithelial and nonepithelial tissues, with several antioxidant, detoxification, and structural genes being highly expressed in both the bronchus and nose. Principle component analysis of previously defined smoking-induced genes from the bronchus suggested that smoking had a similar effect on gene expression in nasal epithelium. Gene set enrichment analysis demonstrated that this set of genes was also highly enriched among the genes most altered by smoking in both nasal and buccal epithelial samples. The expression of several detoxification genes was commonly altered by smoking in all three respiratory epithelial tissues, suggesting a common airway-wide response to tobacco exposure. Conclusion Our findings support a relationship between gene expression in extra- and intrathoracic airway epithelial cells and extend the concept of a smoking-induced field of injury to epithelial cells that line the mouth and nose. This relationship could potentially be utilized to develop a non-invasive biomarker for tobacco exposure as well as a non-invasive screening or diagnostic tool providing information about individual susceptibility to smoking-induced lung diseases.

Published
2008
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11. Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer

Author

Spira, Avrum, Beane, Jennifer E., Shah, Vishal, Steiling, Katrina, Liu, Gang, Schembri, Frank, Gilman, Sean, Dumas, Yves-Martine, Calner, Paul, Sebastiani, Paola, Sridhar, Sriram, Beamis, John, Lamb, Carla, Anderson, Timothy, Gerry, Norman, Keane, Joseph, Lenburg, Marc E., and Brody, Jerome S.

Abstract

Author(s): Avrum Spira (corresponding author) [1]; Jennifer E Beane [2, 8]; Vishal Shah [2, 8]; Katrina Steiling [1]; Gang Liu [1]; Frank Schembri [1]; Sean Gilman [3]; Yves-Martine Dumas [1]; [...]

Published
2007
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12. Lung Cancer

Author

Marquez, Hector, primary, Govender, Praveen, additional, Brody, Jerome S., additional, and Kathuria, Hasmeena, additional

Published
2013
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13. Contributors

Author

Ackerman, Michael J., primary, Ahmed, Minhaz Uddin, additional, Ahn, Sun Hee, additional, Allingham, R. Rand, additional, Alsarraj, Jude, additional, Anderson, Matthew L., additional, Annex, Brian H., additional, Augustine, Christina K., additional, Baranzini, Sergio E., additional, Barnes, Peter J., additional, Beasley, Georgia M., additional, Becker, Richard C., additional, Benjamin, Ivor J., additional, Benson, D. Woodrow, additional, Bentzon, Jacob Fog, additional, Bernard, Philip S., additional, Bertram, Lars, additional, Beskow, Laura M., additional, Bondy, Brigitta, additional, Bos, J. Martijn, additional, Boulting, Gabriella L., additional, Brody, Jerome S., additional, Brown, April S., additional, Buetow, Kenneth H., additional, Bullinger, Lars, additional, Butte, Atul J., additional, Carey, David J., additional, Carlson, George, additional, Chen, David, additional, Chahrour, Maria, additional, Chiocca, E. Antonio, additional, Cho, Alex H., additional, Compton, Carolyn, additional, Cook-Deegan, Robert, additional, Craddock, Nicholas, additional, Coulter, Michael, additional, Damani, Samir B., additional, Danik, Jacqueline S., additional, Dave, Sandeep, additional, Dedrick, Russell, additional, DeLeo, Frank R., additional, Diamandis, Eleftherios P., additional, Dokun, Ayotunde O., additional, Downing, Gregory J., additional, Eck, Stephen L., additional, Edelman, Lucas B., additional, Eggan, Kevin C., additional, Falk, Erling, additional, Faruki, Hawazin, additional, Feng, Junjie, additional, Festen, Eleanora Anna Margaretha, additional, Florez, Jose C., additional, Fowler, Vance G., additional, Freedman, Jennifer A., additional, Freeze, Hudson H., additional, Fröhling, Stefan, additional, Galas, David J., additional, Gerhard, Glenn S., additional, Geschwind, Daniel H., additional, van Kessel, Ad Geurts, additional, Giffin, Robert B., additional, Ginsburg, Geoffrey S., additional, Goodall, Megan, additional, Govender, Praveen, additional, Green, Robert C., additional, Gunter, Chris, additional, Gwinn, Marta, additional, Haga, Susanne B., additional, Heath, James R., additional, Hegele, Robert A., additional, Holton, John, additional, Hood, Leroy, additional, Hunter, Kent W., additional, Hwang, Daehee, additional, Javitt, Gail, additional, Jefferson, Gina, additional, John, Sam, additional, Johnson, Keith J., additional, Johnson, Toby, additional, Joy, Tisha R., additional, Kathiresan, Sekar, additional, Kathuria, Hasmeena, additional, Katwal, Arabindra B., additional, Kawamoto, Kensaku, additional, Kelly, Andrea, additional, Khoury, Muin J., additional, Kim, Jin Woo, additional, Kingsmore, Stephen F., additional, Klingler, Tod, additional, Kobayashi, Scott D., additional, Kohane, Isaac S., additional, Kraus, Virginia Byers, additional, Kuiper, Roland P., additional, Lai-Goldman, Myla, additional, Lamb, Neil E., additional, Lambova, Sevdalina Nikolova, additional, Lanktree, Matthew B., additional, Lawler, Sean E., additional, Ledbetter, David H., additional, Lee, Charles, additional, Lee, Inyoul, additional, Le Roch, Karine G., additional, Levy, Samuel, additional, Limou, Sophie, additional, Liu, Wennuan, additional, Liu, Yutao, additional, London, Barry, additional, MacKeigan, Jeffrey P., additional, Mardis, Elaine R., additional, Marquez, Hector, additional, Marra, Marco, additional, Martin, Christa Lese, additional, Martin, Lisa J., additional, McCarroll, Steven A., additional, McHutchison, John, additional, McLeod, Howard L., additional, Mejías, Asunción, additional, Meltzer, Eric B., additional, Moody, M. Anthony, additional, Morin, Ryan D., additional, Moseley, M. Arthur, additional, Mountain, Joanna L., additional, Müller-Ladner, Ulf, additional, Munroe, Patricia B., additional, Ng, Bobby G., additional, Noble, Paul W., additional, O’Donovan, Michael C., additional, Odunsi, Kunle, additional, Omenn, Gilbert S., additional, Ommen, Steve R., additional, Orlando, Lori A., additional, Osterhaus, Albert D.M.E., additional, Owen, Michael J., additional, Parikshak, Neelroop N., additional, Patel, Keyur, additional, Pavlou, Maria P., additional, Paynter, Nina P., additional, Pejovic, Tanja, additional, Pham, Michael X., additional, Plenge, Robert M., additional, Podgoreanu, Mihai V., additional, Ponts, Nadia, additional, Price, Nathan D., additional, Quinn, Bruce, additional, Quintana, Francisco J., additional, Rader, Daniel J., additional, Ramilo, Octavio, additional, Rehm, Heidi L., additional, Rhodes, Benjamin, additional, Ridker, Paul M., additional, Riggs, Erin Rooney, additional, Ross, Jeffrey S., additional, Rubinstein, Wendy S., additional, Saunders, Carol J., additional, Scott, Joan, additional, Shackel, Nicholas A., additional, Shah, Svati H., additional, Simon, Richard, additional, Sisodiya, Sanjay M., additional, Smits, Saskia L., additional, Stamatoyannopoulos, John A., additional, Steele, Glenn D., additional, Steele, Mark P., additional, Stewart, Tessandra, additional, Thomas, Giovana R., additional, Topol, Eric J., additional, Tunis, Sean R., additional, Turner, Aubrey R., additional, Tyler, Douglas S., additional, Veenstra, David L., additional, Venkatachalam, Ramprasath, additional, Voora, Deepak, additional, Vyse, Timothy J., additional, Walsh, Christopher A., additional, Walsh, Katherine, additional, Wang, Hao, additional, Wang, Jun, additional, Weersma, Rinse K., additional, Weiner, Howard L., additional, Weiss, Scott T., additional, Wester, C. William, additional, Wholley, David N., additional, Wiggs, Janey L., additional, Wijmenga, Cisca, additional, Willard, Huntington F., additional, Williams, Hywel J., additional, Williams, Marc S., additional, Winkler, Cheryl A., additional, Woodcock, Janet, additional, Woods, Christopher W., additional, Wu, Pae C., additional, Xu, Jianfeng, additional, Yee, James, additional, Yoo, Hyuntae, additional, Yu, Timothy, additional, Zhang, Jing, additional, and Zhang, Yurong, additional

Published
2013
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15. Contributors

Author

Ackerman, Michael J., primary, Barnes, Peter J., additional, Becker, Richard, additional, Benjamin, Ivor J., additional, Boguski, Mark, additional, Bondy, Brigitta, additional, Breitbart, Roger E., additional, Brody, Jerome S., additional, Bullinger, Lars, additional, Butte, Atul, additional, Chung, Wendy K., additional, Cottrell, Susan E., additional, Cox, Nancy J., additional, Febbo, Phillip G., additional, Gerhard, Glenn S., additional, Ginsburg, Geoffrey S., additional, Goldstein, David B., additional, Grossman, Iris, additional, Haga, Susanne, additional, Holton, John, additional, Hood, Leroy, additional, Huang, Andrew T., additional, Johnson, Melissa, additional, Khoury, Muin, additional, Lawler, Sean, additional, Lee, Charles, additional, Levy, Samuel, additional, Alfredo Martínez, J., additional, McGrath, Kevin, additional, McHutchison, John, additional, Newby, L. Kristin, additional, Newgard, Christopher, additional, Noble, Paul, additional, Nussbaum, Robert L., additional, Pejovic, Tanya, additional, Plenge, Robert, additional, Quertermous, Thomas, additional, Rader, Daniel J., additional, Ramaswamy, Sridhar, additional, Rimsza, Lisa, additional, Ross, Jeffrey, additional, Shannon, M. Frances, additional, Shianna, Kevin, additional, Singleton, Andrew, additional, Snyderman, Ralph, additional, Stewart, Alison, additional, Thomas, Giovana, additional, Topol, Eric J., additional, Towbin, Jeffrey A., additional, Veenstra, Timothy D., additional, Veenstra, David L., additional, Weiner, Howard L., additional, Weiss, Scott T., additional, Wiesner, Georgia, additional, Wiggs, Janey L., additional, Wijmenga, Cisca, additional, Willard, Huntington F., additional, Woodcock, Janet, additional, Woods, Christopher, additional, and Yagil, Yoram, additional

Published
2010
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17. Microsensor Arrays for Saliva Diagnostics

Author

WALT, DAVID R., BLICHARZ, TIMOTHY M., HAYMAN, RYAN B., RISSIN, DAVID M., BOWDEN, MICHAELA, SIQUEIRA, WALTER L., HELMERHORST, EVA J., GRAND-PIERRE, NERLINE, OPPENHEIM, FRANK G., BHATIA, JASVINDER S., LITTLE, FRÉDÉRIC F., and BRODY, JEROME S.

Published
2007

20. Type I receptor serine-threonine kinase preferentially expressed in pulmonary blood vessels

Author

Panchenko, Mikhail P., Williams, Mary C., Brody, Jerome S., and Yu, Qiang

Subjects
Pulmonary circulation -- Physiological aspects, Transforming growth factors -- Research, Biological sciences
Abstract

Receptor serine threonine kinases (RSTK) were identified in different human and rat tissues where they appear to participate in cellular signalling and work by mediating and transforming growth factor-beta. The gene sequence coding for these receptors was found in both rat and human DNA. Specialized-type variations of these receptors occur in various tissues, such as the activin type present in developing airways and the R-3 variety in blood vessels.

Published
1996

49. Smoking-induced gene expression changes in the bronchial airway are reflected in nasal and buccal epithelium

Author

Sridhar, Sriram, primary, Schembri, Frank, additional, Zeskind, Julie, additional, Shah, Vishal, additional, Gustafson, Adam M, additional, Steiling, Katrina, additional, Liu, Gang, additional, Dumas, Yves-Martine, additional, Zhang, Xiaohui, additional, Brody, Jerome S, additional, Lenburg, Marc E, additional, and Spira, Avrum, additional

Published
2008
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