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1. Phenology under bottom-up control: change in host quality induces diapause in parasitic wasps

Author

Tougeron, Kévin, Brodeur, Jacques, van Baaren, Joan, Renault, David, and Le Lann, Cécile

Subjects
Archaeology, CC1-960, Science
Abstract

When organisms coevolve, any change in one species can affect phenotypes and ecology of the other species. Upper trophic levels have to synchronize their life-cycle to both abiotic conditions and lower trophic level species phenotypic variations and phenology. The role such interactions play in ecosystems is central, but their mechanistic bases remain underexplored. We tested the effect of seasonal variation in host quality on parasitoid diapause induction by using viviparous and oviparous female morphs of the pea aphid Acyrthosiphon pisum. Aphidius ervi parasitoids from two populations of contrasted climatic origin (harsh vs. mild winter areas) were allowed to parasitize each morph in a split-brood design and were next reared under either fall-like or summer-like temperature-photoperiod conditions. We found that oviparous morphs, present before winter, are cues per se for diapause induction; parasitoids entered diapause at higher levels when developing in oviparous hosts (19.4 3.0%) than in viviparous ones (3.6 1.3%), under summer-like conditions (i.e., when oviparous aphids appear in the fields). This pattern was only observed in parasitoids from the harsh winter area, suggesting local adaptations to variation in host quality as an overwintering cue. Analyses of the relative proportion of forty-seven metabolites and lipid reserves in both aphid morphs produced under the same conditions suggest parasitoids response to be mainly influenced by chemical cues derived from the host, with higher proportion of polyols and sugars, and more fat reserves being found in oviparous morphs. Host physiological state thus varies across the seasons and represents one of the multiple environmental indicators of upcoming detrimental conditions, affecting parasitoid overwintering strategies and diapause. Our results underline coevolutionary processes between hosts and parasitoids in their area of origin, likely leading to phenological synchronization with the environment. We point out the importance of such bottom-up effects for ecosystem functioning and for the provision of ecosystem services such as biological control.

Published
2021
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7. Chronic Stress Exposure Alters the Gut Barrier: Sex-Specific Effects on Microbiota and Jejunum Tight Junctions

Author

Aardema, Frederic, Bentaleb, Lahcen Ait, Beauchamp, Janique, Bendahmane, Hicham, Benoit, Elise, Bergeron, Lise, Bertone, Armando, Bertrand, Natalie, Berube, Felix-Antoine, Blanchet, Pierre, Boissonneault, Janick, Bolduc, Christine J., Bonin, Jean-Pierre, Borgeat, Francois, Boyer, Richard, Breault, Chantale, Breton, Jean-Jacques, Briand, Catherine, Brodeur, Jacques, Brule, Krystele, Brunet, Lyne, Carriere, Sylvie, Chartrand, Carine, Chenard-Soucy, Rosemarie, Chevrette, Tommy, Cloutier, Emmanuelle, Cloutier, Richard, Cormier, Hugues, Cote, Gilles, Cyr, Joanne, David, Pierre, De Benedictis, Luigi, Delisle, Marie-Claude, Deschenes, Patricia, Desjardins, Cindy D., Desmarais, Gilbert, Dubreucq, Jean-Luc, Dumont, Mimi, Dumais, Alexandre, Ethier, Guylaine, Feltrin, Carole, Felx, Amelie, Findlay, Helen, Fortier, Linda, Fortin, Denise, Fortin, Leo, Francois, Nathe, Gagne, Valerie, Gagnon, Marie-Pierre, Gignac-Hens, Marie-Claude, Giguere, Charles-Edouard, Godbout, Roger, Grou, Christine, Guay, Stephane, Guillem, Francois, Hachimi-Idrissi, Najia, Herry, Christophe, Hodgins, Sheilah, Homayoun, Saffron, Jemel, Boutheina, Joyal, Christian, Kouassi, Edouard, Labelle, Real, Lafortune, Denis, Lahaie, Michel, Lahlafi, Souad, Lalonde, Pierre, Landry, Pierre, Lapaige, Veronique, Larocque, Guylaine, Larue, Caroline, Lavoie, Marc, Leclerc, Jean-Jacques, Lecomte, Tania, Lecours, Cecile, Leduc, Louise, Lelan, Marie-France, Lemieux, Andre, Lesage, Alain, Letarte, Andree, Lepage, Jean, Levesque, Alain, Lipp, Olivier, Luck, David, Lupien, Sonia, Lusignan, Felix-Antoine, Lusignan, Richard, Luyet, Andre J., Lynhiavu, Alykhanhthi, Melun, Jean-Pierre, Morin, Celine, Nicole, Luc, Noel, Francois, Normandeau, Louise, O’Connor, Kieron, Ouellette, Christine, Parent, Veronique, Parizeau, Marie-Helene, Pelletier, Jean-Francois, Pelletier, Julie, Pelletier, Marc, Plusquellec, Pierrich, Poirier, Diane, Potvin, Stephane, Prevost, Guylaine, Prevost, Marie-Josee, Racicot, Pierre, Racine-Gagne, Marie-France, Renaud, Patrice, Ricard, Nicole, Rivet, Sylvie, Rolland, Michel, Sasseville, Marc, Safadi, Gabriel, Smith, Sandra, Smolla, Nicole, Stip, Emmanuel, Teitelbaum, Jakob, Thibault, Alfred, Thibault, Lucie, Thibault, Stephanye, Thomas, Frederic, Todorov, Christo, Tourjman, Valerie, Tranulis, Constantin, Trudeau, Sonia, Trudel, Gilles, Vacri, Nathalie, Valiquette, Luc, Vanier, Claude, Villeneuve, Kathe, Villeneuve, Marie, Vincent, Philippe, Wolfe, Marcel, Xiong, Lan, Zizzi, Angela, Doney, Ellen, Dion-Albert, Laurence, Coulombe-Rozon, Francois, Osborne, Natasha, Bernatchez, Renaud, Paton, Sam E.J., Kaufmann, Fernanda Neutzling, Agomma, Roseline Olory, Solano, José L., Gaumond, Raphael, Dudek, Katarzyna A., Szyszkowicz, Joanna Kasia, Lebel, Manon, Doyen, Alain, Durand, Audrey, Lavoie-Cardinal, Flavie, Audet, Marie-Claude, and Menard, Caroline

Published
2024
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10. “COP26: what is the message for public health?” Response from the Université de Montréal One Health initiative

Author

Aenishaenslin, Cécile, Batal, Malek, Boiteux, Manon, Bouchard, Michèle, Brun, Yves, Brodeur, Jacques, Carabin, Hélène, Carrier, Julie, Kasisi, Robert, Kritikou, Ekat, Lavoie, Jean-Pierre, Lavoie-Tremblay, Mélanie, Merry, Lisa, Monnais, Laurence, Sauvé, Sébastien, Stafford, Luc, Michel, Juan José Torres, and Tremblay, Hugo

Published
2022
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15. Protective Geometry and Reproductive Anatomy as Candidate Determinants of Clutch Size Variation in Pentatomid Bugs

Author

Abram, Paul K., primary, Guerra-Grenier, Eric, additional, Brodeur, Jacques, additional, Capko, Clarissa, additional, Aquino, Michely Ferreira Santos, additional, Beers, Elizabeth H., additional, Blassioli-Moraes, Maria Carolina, additional, Borges, Miguel, additional, Cingolani, M. Fernanda, additional, Cusumano, Antonino, additional, De Clercq, Patrick, additional, Fernandez, Celina A., additional, Gariepy, Tara D., additional, Haye, Tim, additional, Hoelmer, Kim, additional, Laumann, Raul Alberto, additional, Lietti, Marcela, additional, McPherson, J. E., additional, Punschke, Eduardo, additional, Saunders, Thomas E., additional, Zhang, Jin-Ping, additional, and Hardy, Ian C. W., additional

Published
2023
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19. Weighing consequences of action and inaction in invasive insect management

Author

Abram, Paul K., Franklin, Michelle T., Brodeur, Jacques, Cory, Jenny S., McConkey, Aysha, Wyckhuys, Kris A.G., and Heimpel, George E.

Abstract

The rate of insect invasions continues to accelerate, driven by global trade, climate change, and land use modification. Self-sustaining “public interest” tools such as importation biological control can be powerful ways to mitigate the impacts of insect invasions. However, these interventions can fall prey to counterproductive risk-averse attitudes if their risks are not balanced with the consequences of inaction. Failing to intervene can incur opportunity costs and allow the direct and indirect negative effects of invasive species to accumulate over time. Here, we argue for the explicit consideration of both risks and benefits, expressed in a broad range of currencies, for existing and emerging self-sustaining interventions such as biological control and genetic interventions. An appropriate level of focus on not only the risks of interventions, but also on the multi-faceted risks of inaction, could help to encourage responsible implementation of invasive insect management.

Published
2024
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23. Toxoplasma gondii infection in people with schizophrenia is related to higher hair glucocorticoid levels.

Author

Beaumont, Emy, Brodeur, Jacques, Thomas, Frédéric, Dujon, Antoine M., Signature, Consortium, and Lupien, Sonia J.

Subjects
PEOPLE with schizophrenia, TOXOPLASMA gondii, MENTAL illness, BEHAVIOR modification, GLUCOCORTICOIDS, FEAR
Abstract

Introduction: Toxoplasma gondii (TG) is a common protozoan parasite infecting approximately one third of the human population. Animal studies have shown that this parasite can manipulate its host behavior. Based on this, human studies have assessed if TG can be involved in mental health disorders associated with important behavioral modifications such as schizophrenia. However, results have been discrepant. Given that TG has a strong impact on fear and risk-taking processes in animal studies and that fear and risk-taking behaviors are associated with the human stress response, we tested whether glucocorticoid biomarkers (salivary and hair) differ in people with schizophrenia and controls as a function of TG status. Methods: We measured TG antibodies in blood samples, as well as salivary and hair glucocorticoid levels in 226 people with schizophrenia (19.9% women, mean age = 39 years old) and 129 healthy individuals (controls) (45.7% women, mean age = 41 years old). Results: The results showed that people with schizophrenia infected with TG presented significantly higher hair glucocorticoid concentrations than noninfected people with schizophrenia. This effect was not found in control participants. No effect was observed for salivary glucocorticoid levels. Additionally, there were no associations between TG infection and positive psychotic symptoms nor impulsivity. Discussion: These results show that people with schizophrenia present high levels of hair glucocorticoid levels only when they are infected with TG. Further studies performed in populations suffering from other mental health disorders are needed to determine if this effect is specific to schizophrenia, or whether it is generalized across mental health disorders. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Scientists' warning on climate change and insects

Author

Harvey, Jeffrey A., Tougeron, Kévin, Gols, Rieta, Heinen, Robin, Abarca, Mariana, Abram, Paul K., Basset, Yves, Berg, Matty, Boggs, Carol, Brodeur, Jacques, Cardoso, Pedro, de Boer, Jetske G., De Snoo, Geert R., Deacon, Charl, Dell, Jane E., Desneux, Nicolas, Dillon, Michael E., Duffy, Grant A., Dyer, Lee A., Ellers, Jacintha, Espíndola, Anahí, Fordyce, James, Forister, Matthew L., Fukushima, Caroline, Gage, Matthew J. G., García‐Robledo, Carlos, Gely, Claire, Gobbi, Mauro, Hallmann, Caspar, Hance, Thierry, Harte, John, Hochkirch, Axel, Hof, Christian, Hoffmann, Ary A., Kingsolver, Joel G., Lamarre, Greg P. A., Laurance, William F., Lavandero, Blas, Leather, Simon R., Lehmann, Philipp, Le Lann, Cécile, López‐Uribe, Margarita M., Ma, Chun‐Sen, Ma, Gang, Moiroux, Joffrey, Monticelli, Lucie, Nice, Chris, Ode, Paul J., Pincebourde, Sylvain, Ripple, William J., Rowe, Melissah, Samways, Michael J., Sentis, Arnaud, Shah, Alisha A., Stork, Nigel, Terblanche, John S., Thakur, Madhav P., Thomas, Matthew B., Tylianakis, Jason M., Van Baaren, Joan, Van de Pol, Martijn, Van der Putten, Wim H., Van Dyck, Hans, Verberk, Wilco C. E. P., Wagner, David L., Weisser, Wolfgang W., Wetzel, William C., Woods, H. Arthur, Wyckhuys, Kris A. G., Chown, Steven L., Harvey, Jeffrey A., Tougeron, Kévin, Gols, Rieta, Heinen, Robin, Abarca, Mariana, Abram, Paul K., Basset, Yves, Berg, Matty, Boggs, Carol, Brodeur, Jacques, Cardoso, Pedro, de Boer, Jetske G., De Snoo, Geert R., Deacon, Charl, Dell, Jane E., Desneux, Nicolas, Dillon, Michael E., Duffy, Grant A., Dyer, Lee A., Ellers, Jacintha, Espíndola, Anahí, Fordyce, James, Forister, Matthew L., Fukushima, Caroline, Gage, Matthew J. G., García‐Robledo, Carlos, Gely, Claire, Gobbi, Mauro, Hallmann, Caspar, Hance, Thierry, Harte, John, Hochkirch, Axel, Hof, Christian, Hoffmann, Ary A., Kingsolver, Joel G., Lamarre, Greg P. A., Laurance, William F., Lavandero, Blas, Leather, Simon R., Lehmann, Philipp, Le Lann, Cécile, López‐Uribe, Margarita M., Ma, Chun‐Sen, Ma, Gang, Moiroux, Joffrey, Monticelli, Lucie, Nice, Chris, Ode, Paul J., Pincebourde, Sylvain, Ripple, William J., Rowe, Melissah, Samways, Michael J., Sentis, Arnaud, Shah, Alisha A., Stork, Nigel, Terblanche, John S., Thakur, Madhav P., Thomas, Matthew B., Tylianakis, Jason M., Van Baaren, Joan, Van de Pol, Martijn, Van der Putten, Wim H., Van Dyck, Hans, Verberk, Wilco C. E. P., Wagner, David L., Weisser, Wolfgang W., Wetzel, William C., Woods, H. Arthur, Wyckhuys, Kris A. G., and Chown, Steven L.

Abstract

Climate warming is considered to be among the most serious of anthropogenicstresses to the environment, because it not only has direct effects on biodiver-sity, but it also exacerbates the harmful effects of other human-mediated threats. The associated consequences are potentially severe, particularly interms of threats to species preservation, as well as in the preservation of anarray of ecosystem services provided by biodiversity. Among the most affectedgroups of animals are insects—central components of many ecosystems—forwhich climate change has pervasive effects from individuals to communities.In this contribution to the scientists’warning series, we summarize the effectof the gradual global surface temperature increase on insects, in terms ofphysiology, behavior, phenology, distribution, and species interactions, as wellas the effect of increased frequency and duration of extreme events such as hotand cold spells, fires, droughts, and floods on these parameters. We warn that,if no action is taken to better understand and reduce the action of climatechange on insects, we will drastically reduce our ability to build a sustainablefuture based on healthy, functional ecosystems. We discuss perspectives onrelevant ways to conserve insects in the face of climate change, and we offerseveral key recommendations on management approaches that can beadopted, on policies that should be pursued, and on the involvement of thegeneral public in the protection effort.

Published
2023

30. Chronic Stress Exposure Alters the Gut Barrier: Sex-Specific Effects on Microbiota and Jejunum Tight Junctions

Author

Doney, Ellen, Dion-Albert, Laurence, Coulombe-Rozon, Francois, Osborne, Natasha, Bernatchez, Renaud, Paton, Sam E.J., Kaufmann, Fernanda Neutzling, Agomma, Roseline Olory, Solano, José L., Gaumond, Raphael, Dudek, Katarzyna A., Szyszkowicz, Joanna Kasia, Aardema, Frederic, Bentaleb, Lahcen Ait, Beauchamp, Janique, Bendahmane, Hicham, Benoit, Elise, Bergeron, Lise, Bertone, Armando, Bertrand, Natalie, Berube, Felix-Antoine, Blanchet, Pierre, Boissonneault, Janick, Bolduc, Christine J., Bonin, Jean-Pierre, Borgeat, Francois, Boyer, Richard, Breault, Chantale, Breton, Jean-Jacques, Briand, Catherine, Brodeur, Jacques, Brule, Krystele, Brunet, Lyne, Carriere, Sylvie, Chartrand, Carine, Chenard-Soucy, Rosemarie, Chevrette, Tommy, Cloutier, Emmanuelle, Cloutier, Richard, Cormier, Hugues, Cote, Gilles, Cyr, Joanne, David, Pierre, De Benedictis, Luigi, Delisle, Marie-Claude, Deschenes, Patricia, Desjardins, Cindy D., Desmarais, Gilbert, Dubreucq, Jean-Luc, Dumont, Mimi, Dumais, Alexandre, Ethier, Guylaine, Feltrin, Carole, Felx, Amelie, Findlay, Helen, Fortier, Linda, Fortin, Denise, Fortin, Leo, Francois, Nathe, Gagne, Valerie, Gagnon, Marie-Pierre, Gignac-Hens, Marie-Claude, Giguere, Charles-Edouard, Godbout, Roger, Grou, Christine, Guay, Stephane, Guillem, Francois, Hachimi-Idrissi, Najia, Herry, Christophe, Hodgins, Sheilah, Homayoun, Saffron, Jemel, Boutheina, Joyal, Christian, Kouassi, Edouard, Labelle, Real, Lafortune, Denis, Lahaie, Michel, Lahlafi, Souad, Lalonde, Pierre, Landry, Pierre, Lapaige, Veronique, Larocque, Guylaine, Larue, Caroline, Lavoie, Marc, Leclerc, Jean-Jacques, Lecomte, Tania, Lecours, Cecile, Leduc, Louise, Lelan, Marie-France, Lemieux, Andre, Lesage, Alain, Letarte, Andree, Lepage, Jean, Levesque, Alain, Lipp, Olivier, Luck, David, Lupien, Sonia, Lusignan, Felix-Antoine, Lusignan, Richard, Luyet, Andre J., Lynhiavu, Alykhanhthi, Melun, Jean-Pierre, Morin, Celine, Nicole, Luc, Noel, Francois, Normandeau, Louise, O’Connor, Kieron, Ouellette, Christine, Parent, Veronique, Parizeau, Marie-Helene, Pelletier, Jean-Francois, Pelletier, Julie, Pelletier, Marc, Plusquellec, Pierrich, Poirier, Diane, Potvin, Stephane, Prevost, Guylaine, Prevost, Marie-Josee, Racicot, Pierre, Racine-Gagne, Marie-France, Renaud, Patrice, Ricard, Nicole, Rivet, Sylvie, Rolland, Michel, Sasseville, Marc, Safadi, Gabriel, Smith, Sandra, Smolla, Nicole, Stip, Emmanuel, Teitelbaum, Jakob, Thibault, Alfred, Thibault, Lucie, Thibault, Stephanye, Thomas, Frederic, Todorov, Christo, Tourjman, Valerie, Tranulis, Constantin, Trudeau, Sonia, Trudel, Gilles, Vacri, Nathalie, Valiquette, Luc, Vanier, Claude, Villeneuve, Kathe, Villeneuve, Marie, Vincent, Philippe, Wolfe, Marcel, Xiong, Lan, Zizzi, Angela, Lebel, Manon, Doyen, Alain, Durand, Audrey, Lavoie-Cardinal, Flavie, Audet, Marie-Claude, and Menard, Caroline

Abstract

Major depressive disorder (MDD) is the leading cause of disability worldwide. Of individuals with MDD, 30% to 50% are unresponsive to common antidepressants, highlighting untapped causal biological mechanisms. Dysfunction in the microbiota-gut-brain axis has been implicated in MDD pathogenesis. Exposure to chronic stress disrupts blood-brain barrier integrity; still, little is known about intestinal barrier function in these conditions, particularly for the small intestine, where absorption of most foods and drugs takes place.

Published
2024
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37. Scientists' warning on climate change and insects

Author

Harvey, Jeffrey A., primary, Tougeron, Kévin, additional, Gols, Rieta, additional, Heinen, Robin, additional, Abarca, Mariana, additional, Abram, Paul K., additional, Basset, Yves, additional, Berg, Matty, additional, Boggs, Carol, additional, Brodeur, Jacques, additional, Cardoso, Pedro, additional, de Boer, Jetske G., additional, De Snoo, Geert R., additional, Deacon, Charl, additional, Dell, Jane E., additional, Desneux, Nicolas, additional, Dillon, Michael E., additional, Duffy, Grant A., additional, Dyer, Lee A., additional, Ellers, Jacintha, additional, Espíndola, Anahí, additional, Fordyce, James, additional, Forister, Matthew L., additional, Fukushima, Caroline, additional, Gage, Matthew J. G., additional, García‐Robledo, Carlos, additional, Gely, Claire, additional, Gobbi, Mauro, additional, Hallmann, Caspar, additional, Hance, Thierry, additional, Harte, John, additional, Hochkirch, Axel, additional, Hof, Christian, additional, Hoffmann, Ary A., additional, Kingsolver, Joel G., additional, Lamarre, Greg P. A., additional, Laurance, William F., additional, Lavandero, Blas, additional, Leather, Simon R., additional, Lehmann, Philipp, additional, Le Lann, Cécile, additional, López‐Uribe, Margarita M., additional, Ma, Chun‐Sen, additional, Ma, Gang, additional, Moiroux, Joffrey, additional, Monticelli, Lucie, additional, Nice, Chris, additional, Ode, Paul J., additional, Pincebourde, Sylvain, additional, Ripple, William J., additional, Rowe, Melissah, additional, Samways, Michael J., additional, Sentis, Arnaud, additional, Shah, Alisha A., additional, Stork, Nigel, additional, Terblanche, John S., additional, Thakur, Madhav P., additional, Thomas, Matthew B., additional, Tylianakis, Jason M., additional, Van Baaren, Joan, additional, Van de Pol, Martijn, additional, Van der Putten, Wim H., additional, Van Dyck, Hans, additional, Verberk, Wilco C. E. P., additional, Wagner, David L., additional, Weisser, Wolfgang W., additional, Wetzel, William C., additional, Woods, H. Arthur, additional, Wyckhuys, Kris A. G., additional, and Chown, Steven L., additional

Published
2022
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47. Protective geometry and reproductive anatomy as candidate determinants of clutch size variation in pentatomid bugs

Author

Abram, Paul K, primary, Guerra-Grenier, Eric, additional, Brodeur, Jacques, additional, Capko, Clarissa, additional, Aquino, Michely Ferreira Santos, additional, Beers, Betsy, additional, Blassioli-Moraes, Maria Carolina, additional, Borges, Miguel, additional, Cingolani, M. Fernanda, additional, Cusumano, Antonino, additional, DeClercq, Patrick, additional, Fernandez, Celina A., additional, Gariepy, Tara D., additional, Haye, Tim, additional, Hoelmer, Kim, additional, Laumann, Raul Alberto, additional, Lietti, Marcela, additional, McPherson, J. E., additional, Punschke, Eduardo, additional, Saunders, Thomas E., additional, Zhang, Jin Ping, additional, and Hardy, Ian C.W., additional

Published
2022
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48. Vascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue

Author

Dion-Albert, Laurence, Cadoret, Alice, Doney, Ellen, Kaufmann, Fernanda Neutzling, Dudek, Katarzyna A., Daigle, Beatrice, Parise, Lyonna F., Cathomas, Flurin, Samba, Nalia, Hudson, Natalie, Lebel, Manon, Aardema, Frederic, Ait Bentaleb, Lahcen, Beauchamp, Janique, Bendahmane, Hicham, Benoit, Elise, Bergeron, Lise, Bertone, Armando, Bertrand, Natalie, Berube, Felix-Antoine, Blanchet, Pierre, Boissonneault, Janick, Bolduc, Christine J., Bonin, Jean-Pierre, Borgeat, Francois, Boyer, Richard, Breault, Chantale, Breton, Jean-Jacques, Briand, Catherine, Brodeur, Jacques, Brule, Krystele, Brunet, Lyne, Carriere, Sylvie, Chartrand, Carine, Chenard-Soucy, Rosemarie, Chevrette, Tommy, Cloutier, Emmanuelle, Cloutier, Richard, Cormier, Hugues, Cote, Gilles, Cyr, Joanne, David, Pierre, De Benedictis, Luigi, Delisle, Marie-Claude, Deschenes, Patricia, Desjardins, Cindy D., Desmarais, Gilbert, Dubreucq, Jean-Luc, Dumont, Mimi, Dumais, Alexandre, Ethier, Guylaine, Feltrin, Carole, Felx, Amelie, Findlay, Helen, Fortier, Linda, Fortin, Denise, Fortin, Leo, Francois, Nathe, Gagne, Valerie, Gagnon, Marie-Pierre, Gignac-Hens, Marie-Claude, Giguere, Charles-Edouard, Godbout, Roger, Grou, Christine, Guay, Stephane, Guillem, Francois, Hachimi-Idrissi, Najia, Herry, Christophe, Hodgins, Sheilah, Homayoun, Saffron, Jemel, Boutheina, Joyal, Christian, Kouassi, Edouard, Labelle, Real, Lafortune, Denis, Lahaie, Michel, Lahlafi, Souad, Lalonde, Pierre, Landry, Pierre, Lapaige, Veronique, Larocque, Guylaine, Larue, Caroline, Lavoie, Marc, Leclerc, Jean-Jacques, Lecomte, Tania, Lecours, Cecile, Leduc, Louise, Lelan, Marie-France, Lemieux, Andre, Lesage, Alain, Letarte, Andree, Lepage, Jean, Levesque, Alain, Lipp, Olivier, Luck, David, Lupien, Sonia, Lusignan, Felix-Antoine, Lusignan, Richard, Luyet, Andre J., Lynhiavu, Alykhanhthi, Melun, Jean-Pierre, Morin, Celine, Nicole, Luc, Noel, Francois, Normandeau, Louise, O’Connor, Kieron, Ouellette, Christine, Parent, Veronique, Parizeau, Marie-Helene, Pelletier, Jean-Francois, Pelletier, Julie, Pelletier, Marc, Plusquellec, Pierrich, Poirier, Diane, Potvin, Stephane, Prevost, Guylaine, Prevost, Marie-Josee, Racicot, Pierre, Racine-Gagne, Marie-France, Renaud, Patrice, Ricard, Nicole, Rivet, Sylvie, Rolland, Michel, Sasseville, Marc, Safadi, Gabriel, Smith, Sandra, Smolla, Nicole, Stip, Emmanuel, Teitelbaum, Jakob, Thibault, Alfred, Thibault, Lucie, Thibault, Stephanye, Thomas, Frederic, Todorov, Christo, Tourjman, Valerie, Tranulis, Constantin, Trudeau, Sonia, Trudel, Gilles, Vacri, Nathalie, Valiquette, Luc, Vanier, Claude, Villeneuve, Kathe, Villeneuve, Marie, Vincent, Philippe, Wolfe, Marcel, Xiong, Lan, Zizzi, Angela, Campbell, Matthew, Turecki, Gustavo, Mechawar, Naguib, and Menard, Caroline

Subjects
Male, Science, Prefrontal Cortex, General Physics and Astronomy, Nerve Tissue Proteins, Anxiety, Article, Nucleus Accumbens, General Biochemistry, Genetics and Molecular Biology, Mice, Animals, Humans, skin and connective tissue diseases, Depressive Disorder, Major, Sex Characteristics, Multidisciplinary, Depression, Gene Expression Profiling, Endothelial Cells, Diagnostic markers, Biological Transport, General Chemistry, nervous system, Blood-Brain Barrier, Female, sense organs, E-Selectin, Transcriptome, Stress and resilience, Biomarkers, Stress, Psychological
Abstract

Prevalence, symptoms, and treatment of depression suggest that major depressive disorders (MDD) present sex differences. Social stress-induced neurovascular pathology is associated with depressive symptoms in male mice; however, this association is unclear in females. Here, we report that chronic social and subchronic variable stress promotes blood-brain barrier (BBB) alterations in mood-related brain regions of female mice. Targeted disruption of the BBB in the female prefrontal cortex (PFC) induces anxiety- and depression-like behaviours. By comparing the endothelium cell-specific transcriptomic profiling of the mouse male and female PFC, we identify several pathways and genes involved in maladaptive stress responses and resilience to stress. Furthermore, we confirm that the BBB in the PFC of stressed female mice is leaky. Then, we identify circulating vascular biomarkers of chronic stress, such as soluble E-selectin. Similar changes in circulating soluble E-selectin, BBB gene expression and morphology can be found in blood serum and postmortem brain samples from women diagnosed with MDD. Altogether, we propose that BBB dysfunction plays an important role in modulating stress responses in female mice and possibly MDD., The vascular, cellular and molecular changes underlying sex differences in mood disorders are unclear. Here, the authors show that blood-brain barrier dysfunction modulates anxiety- and depressive-like behaviors in female mice and endothelium-specific changes associated with maladaptive responses compared to resilience to stress.

Published
2022

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