Search

Your search keyword '"Brockmueller, Aranka"' showing total 42 results
Start Over Author "Brockmueller, Aranka"
42 results on '"Brockmueller, Aranka"'

7. Significance of flavonoids targeting PI3K/Akt/HIF-1α signaling pathway in therapy-resistant cancer cells – A potential contribution to the predictive, preventive, and personalized medicine

Author

Mazurakova, Alena, Koklesova, Lenka, Csizmár, Sandra Hurta, Samec, Marek, Brockmueller, Aranka, Šudomová, Miroslava, Biringer, Kamil, Kudela, Erik, Pec, Martin, Samuel, Samson Mathews, Kassayova, Monika, Hassan, Sherif T.S., Smejkal, Karel, Shakibaei, Mehdi, Büsselberg, Dietrich, Saso, Luciano, Kubatka, Peter, and Golubnitschaja, Olga

Published
2024
Full Text
View/download PDF

11. Flavonoids against the SARS-CoV-2 induced inflammatory storm

Author

Liskova, Alena, Samec, Marek, Koklesova, Lenka, Samuel, Samson M., Zhai, Kevin, Al-Ishaq, Raghad Khalid, Abotaleb, Mariam, Nosal, Vladimir, Kajo, Karol, Ashrafizadeh, Milad, Zarrabi, Ali, Brockmueller, Aranka, Shakibaei, Mehdi, Sabaka, Peter, Mozos, Ioana, Ullrich, David, Prosecky, Robert, La Rocca, Giampiero, Caprnda, Martin, Büsselberg, Dietrich, Rodrigo, Luis, Kruzliak, Peter, and Kubatka, Peter

Published
2021
Full Text
View/download PDF

12. Flavonoids as an effective sensitizer for anti-cancer therapy: insights into multi-faceted mechanisms and applicability towards individualized patient profiles

Author

Liskova, Alena, Samec, Marek, Koklesova, Lenka, Brockmueller, Aranka, Zhai, Kevin, Abdellatif, Basma, Siddiqui, Manaal, Biringer, Kamil, Kudela, Erik, Pec, Martin, Gadanec, Laura Kate, Šudomová, Miroslava, Hassan, Sherif T. S., Zulli, Anthony, Shakibaei, Mehdi, Giordano, Frank A., Büsselberg, Dietrich, Golubnitschaja, Olga, and Kubatka, Peter

Published
2021
Full Text
View/download PDF

16. Microbiota and Resveratrol: How Are They Linked to Osteoporosis?

Author

Meyer, Christine, Brockmueller, Aranka, Ruiz de Porras, Vicenç, and Shakibaei, Mehdi

Subjects
*SHORT-chain fatty acids, *PROTON pump inhibitors, *BONE density, *GUT microbiome, *BONE metabolism
Abstract

Osteoporosis (OP), which is characterized by a decrease in bone density and increased susceptibility to fractures, is closely linked to the gut microbiota (GM). It is increasingly realized that the GM plays a key role in the maintenance of the functioning of multiple organs, including bone, by producing bioactive metabolites such as short-chain fatty acids (SCFA). Consequently, imbalances in the GM, referred to as dysbiosis, have been identified with a significant reduction in beneficial metabolites, such as decreased SCFA associated with increased chronic inflammatory processes, including the activation of NF-κB at the epigenetic level, which is recognized as the main cause of many chronic diseases, including OP. Furthermore, regular or long-term medications such as antibiotics and many non-antibiotics such as proton pump inhibitors, chemotherapy, and NSAIDs, have been found to contribute to the development of dysbiosis, highlighting an urgent need for new treatment approaches. A promising preventive and adjuvant approach is to combat dysbiosis with natural polyphenols such as resveratrol, which have prebiotic functions and ensure an optimal microenvironment for beneficial GM. Resveratrol offers a range of benefits, including anti-inflammatory, anti-oxidant, analgesic, and prebiotic effects. In particular, the GM has been shown to convert resveratrol, into highly metabolically active molecules with even more potent beneficial properties, supporting a synergistic polyphenol–GM axis. This review addresses the question of how the GM can enhance the effects of resveratrol and how resveratrol, as an epigenetic modulator, can promote the growth and diversity of beneficial GM, thus providing important insights for the prevention and co-treatment of OP. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

17. Curcumin and its anti‐colorectal cancer potential: From mechanisms of action to autophagy.

Author

Brockmueller, Aranka, Ruiz de Porras, Vicenç, and Shakibaei, Mehdi

Abstract

Colorectal cancer (CRC) development and progression, one of the most common cancers globally, is supported by specific mechanisms to escape cell death despite chemotherapy, including cellular autophagy. Autophagy is an evolutionarily highly conserved degradation pathway involved in a variety of cellular processes, such as the maintenance of cellular homeostasis and clearance of foreign bodies, and its imbalance is associated with many diseases. However, the role of autophagy in CRC progression remains controversial, as it has a dual function, affecting either cell death or survival, and is associated with cellular senescence in tumor therapy. Indeed, numerous data have been presented that autophagy in cancers serves as an alternative to cell apoptosis when the latter is ineffective or in apoptosis‐resistant cells, which is why it is also referred to as programmed cell death type II. Curcumin, one of the active constituents of Curcuma longa, has great potential to combat CRC by influencing various cellular signaling pathways and epigenetic regulation in a safe and cost‐effective approach. This review discusses the efficacy of curcumin against CRC in vitro and in vivo, particularly its modulation of autophagy and apoptosis in various cellular pathways. While clinical studies have assessed the potential of curcumin in cancer prevention and treatment, none have specifically examined its role in autophagy. Nonetheless, we offer an overview of potential correlations to support the use of this polyphenol as a prophylactic or co‐therapeutic agent in CRC. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

23. Significance of flavonoids targeting PI3K/Akt/HIF-1α signaling pathway in therapy-resistant cancer cells – A potential contribution to the predictive, preventive, and personalized medicine

Author

Mazurakova, Alena, primary, Koklesova, Lenka, additional, Csizmár, Sandra Hurta, additional, Samec, Marek, additional, Brockmueller, Aranka, additional, Šudomová, Miroslava, additional, Biringer, Kamil, additional, Kudela, Erik, additional, Pec, Martin, additional, Samuel, Samson Mathews, additional, Kassayova, Monika, additional, Hassan, Sherif T.S., additional, Smejkal, Karel, additional, Shakibaei, Mehdi, additional, Büsselberg, Dietrich, additional, Saso, Luciano, additional, Kubatka, Peter, additional, and Golubnitschaja, Olga, additional

Published
2023
Full Text
View/download PDF

32. Molecular detection of colorectal cancer

Author

Verbanac, Donatella, Čeri, Andrea, Hlapčić, Iva, Shakibaei, Mehdi, Brockmueller, Aranka, Krušlin, Božo, Ljubičić, Neven, Baršić, Neven, Detel, Dijana, Batičić, Lara, Rumora, Lada, Somborac-Bačura, Anita, Štefanović, Mario, Ćelap, Ivana, Demirović, Alma, Petlevski, Roberta, Petrik, József, Grdić Rajković, Marija, Hulina-Tomašković, Andrea, Rako, Ivana, Saso, Luciano, and Barišić, Karmela

Subjects
BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences, biomarkers, colorectal cancer, early detection examination, liquid biopsy, personalized medicine, tumor treatment, exosomes, ctDNA, CTC, BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti, BIOMEDICINE AND HEALTHCARE. Basic Medical Sciences, digestive system diseases, BIOMEDICINA I ZDRAVSTVO. Temeljne medicinske znanosti
Abstract

Drug-specific therapeutic approaches for colorectal cancer (CRC) have contributed to a significant improvement in the health status of patients. However, a great need to improve personalization of treatments based on genetic and epigenetic tumor profiles to maximize quality and efficacy while limiting cytotoxicity remains. Currently, CEA and CA 19- 9 are the only validated blood biomarkers in clinical practice. For this reason, laboratories are trying to identify new specific prognostic and, more importantly, predictive biomarkers for CRC patient profiles. Thus, the unique landscape of personalized biomarker data should have a clinical impact on CRC treatment strategies and molecular genetic screening tests should become the standard method for CRC diagnosis, as well as detection of disease progression.

Published
2021

35. Metabolic Anti-Cancer Effects of Melatonin: Clinically Relevant Prospects

Author

Samec, Marek, primary, Liskova, Alena, additional, Koklesova, Lenka, additional, Zhai, Kevin, additional, Varghese, Elizabeth, additional, Samuel, Samson Mathews, additional, Šudomová, Miroslava, additional, Lucansky, Vincent, additional, Kassayova, Monika, additional, Pec, Martin, additional, Biringer, Kamil, additional, Brockmueller, Aranka, additional, Kajo, Karol, additional, Hassan, Sherif T. S., additional, Shakibaei, Mehdi, additional, Golubnitschaja, Olga, additional, Büsselberg, Dietrich, additional, and Kubatka, Peter, additional

Published
2021
Full Text
View/download PDF

36. Roles of Nrf2 in Gastric Cancer: Targeting for Therapeutic Strategies

Author

Farkhondeh, Tahereh, primary, Pourbagher-Shahri, Ali Mohammad, additional, Azimi-Nezhad, Mohsen, additional, Forouzanfar, Fatemeh, additional, Brockmueller, Aranka, additional, Ashrafizadeh, Milad, additional, Talebi, Marjan, additional, Shakibaei, Mehdi, additional, and Samarghandian, Saeed, additional

Published
2021
Full Text
View/download PDF

37. ß1-Integrin plays a major role in resveratrol-mediated anti-invasion effects in the CRC microenvironment.

Author

Brockmueller, Aranka, Mueller, Anna-Lena, Shayan, Parviz, and Shakibaei, Mehdi

Subjects
ADAPTOR proteins, INTEGRINS, CELL migration, PHENOTYPIC plasticity, RESVERATROL, TUMOR microenvironment, CADHERINS
Abstract

Background: Tumor microenvironment (TME) is one of the most important factors in tumor aggressiveness, with an active exchange between tumor and other TME-associated cells that promotes metastasis. The tumor-inhibitory effect of resveratrol on colorectal cancer (CRC) cells has been frequently reported. However, whether resveratrol can specifically suppress TMEinduced CRC invasion via ß1-integrin receptors has not been fully elucidated yet. Methods: Two CRC cell lines (HCT116, RKO) were cultured in multicellular, proinflammatory 3D-alginate TME cultures (containing fibroblasts, T-lymphocytes) to investigate the role of ß1-integrin receptors in the anti-invasive and antimetastatic effect of resveratrol by antisense oligonucleotides (ASO). Results: Our results show that resveratrol dose-dependently suppressed the migration-promoting adhesion adapter protein paxillin and simultaneously enhanced the expression of E-cadherin associated with the phenotype change of CRC cells, and their invasion. Moreover, resveratrol blocked TMEinduced phosphorylation and nuclear translocation of p65-NF-κB, which was associated with changes in the expression pattern of epithelial-mesenchymaltransition-related biomarkers (slug, vimentin, E-cadherin), metastasis-related factors (CXCR4, MMP-9, FAK), and apoptosis (caspase-3). Finally, transient transfection of ß1-integrin, in contrast to knockdown of NF-κB, abrogated most anti-invasive, anti-metastatic effects as well as downstream signaling of resveratrol, resulting in a concomitant increase in CRC cell invasion, indicating a central role of ß1-integrin receptors in the anti-invasive function of resveratrol. Conclusion: These results demonstrate for the first time that silencing ß1-integrins may suppress, at least in part the inhibitory effects of resveratrol on invasion and migration of CRC cells, underscoring the crucial homeostatic role of ß1-integrin receptors. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

38. Profiling Colorectal Cancer in the Landscape Personalized Testing—Advantages of Liquid Biopsy

Author

Verbanac, Donatella, primary, Čeri, Andrea, additional, Hlapčić, Iva, additional, Shakibaei, Mehdi, additional, Brockmueller, Aranka, additional, Krušlin, Božo, additional, Ljubičić, Neven, additional, Baršić, Neven, additional, Detel, Dijana, additional, Batičić, Lara, additional, Rumora, Lada, additional, Somborac-Bačura, Anita, additional, Štefanović, Mario, additional, Ćelap, Ivana, additional, Demirović, Alma, additional, Petlevski, Roberta, additional, Petrik, József, additional, Grdić Rajković, Marija, additional, Hulina-Tomašković, Andrea, additional, Rako, Ivana, additional, Saso, Luciano, additional, and Barišić, Karmela, additional

Published
2021
Full Text
View/download PDF

40. Flavonoids Targeting HIF-1: Implications on Cancer Metabolism

Author

Samec, Marek, primary, Liskova, Alena, additional, Koklesova, Lenka, additional, Mersakova, Sandra, additional, Strnadel, Jan, additional, Kajo, Karol, additional, Pec, Martin, additional, Zhai, Kevin, additional, Smejkal, Karel, additional, Mirzaei, Sepideh, additional, Hushmandi, Kiavash, additional, Ashrafizadeh, Milad, additional, Saso, Luciano, additional, Brockmueller, Aranka, additional, Shakibaei, Mehdi, additional, Büsselberg, Dietrich, additional, and Kubatka, Peter, additional

Published
2021
Full Text
View/download PDF

41. Carotenoids in Cancer Metastasis—Status Quo and Outlook

Author

Koklesova, Lenka, primary, Liskova, Alena, additional, Samec, Marek, additional, Zhai, Kevin, additional, Abotaleb, Mariam, additional, Ashrafizadeh, Milad, additional, Brockmueller, Aranka, additional, Shakibaei, Mehdi, additional, Biringer, Kamil, additional, Bugos, Ondrej, additional, Najafi, Masoud, additional, Golubnitschaja, Olga, additional, Büsselberg, Dietrich, additional, and Kubatka, Peter, additional

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results