1,743 results on '"Brocklehurst P"'
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2. Insurance loss model vs. meteorological loss index – how comparable are their loss estimates for European windstorms?
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J. Moemken, I. Alifdini, A. M. Ramos, A. Georgiadis, A. Brocklehurst, L. Braun, and J. G. Pinto
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Environmental technology. Sanitary engineering ,TD1-1066 ,Geography. Anthropology. Recreation ,Environmental sciences ,GE1-350 ,Geology ,QE1-996.5 - Abstract
Windstorms affecting Europe are among the natural hazards with the largest socio-economic impacts. Therefore, many sectors like society, the economy, or the insurance industry are highly interested in reliable information on associated impacts and losses. In this study, we compare – for the first time – estimated windstorm losses using a simplified meteorological loss index (LI) with losses obtained from a complex insurance loss (catastrophe) model, namely the European Windstorm Model of Aon Impact Forecasting. To test the sensitivity of LI to different meteorological input data, we furthermore contrast LI based on the reanalysis dataset ERA5 and its predecessor ERA-Interim. We focus on similarities and differences between the datasets in terms of loss values and storm rank for specific historical storm events in the common reanalysis period across 11 European countries. Our results reveal higher LI values for ERA5 than for ERA-Interim for all of Europe (by roughly a factor of 10), coming mostly from the higher spatial resolution in ERA5. The storm ranking is comparable for western and central European countries for both reanalyses, confirmed by high correlation values between 0.6 and 0.89. Compared to the Aon Impact Forecasting model, LI ERA5 shows comparable storm ranks, with correlation values ranging between 0.45 and 0.8. In terms of normalized loss, LI exhibits overall lower values and smaller regional differences. Compared to the market perspective represented by the insurance loss model, LI seems to have particular difficulty in distinguishing between high-impact events at the tail of the wind gust distribution and moderate-impact events. Thus, the loss distribution in LI is likely not steep enough, and the tail is probably underestimated. Nevertheless, it is an effective index that is suitable for estimating the impacts of storm events and ranking storm events, precisely because of its simplicity.
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- 2024
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3. Leadership in dentistry: findings from new tool to measure clinical leadership
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Hill H and Brocklehurst P
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Public aspects of medicine ,RA1-1270 - Abstract
Harry Hill,1 Paul Brocklehurst2 1The Manchester Centre for Health Economics and School of Dentistry, University of Manchester, Manchester, UK; 2School of Dentistry, University of Manchester, Manchester, UK Background: In England, the recent reorganization of the National Health Service has led to the development of local dental networks and an emerging narrative on the importance of clinical leadership in dentistry. Analogous to clinical commissioning groups, local dental networks ensure general dental practitioners (GDPs) influence the delivery of local services. However, little is known about what GDPs think clinical leadership is and whether the construct has meaning. The aim of this study was to explore the structure of a pilot questionnaire to determine the qualities that GDPs deem are important and to use a data reduction methodology to produce a tool to measure clinical leadership. Methods: A 61-item questionnaire was distributed to GDPs across the North West of England. GDPs were asked to rate the level of importance of each item using a 7-point Likert scale. Principal component analysis and direct oblimin rotation was used to examine for factor loadings within the questionnaire. Internal validity was tested by Cronbach's alpha. Results: Two principle factors emerged: “how to lead” and “how not to lead”. Individually, the item “I think it is important to have integrity” was rated as the most important. Conclusion: The study developed a refined questionnaire that captures the important qualities of clinical leadership in dentistry. This is the first questionnaire that has been developed to capture important leadership attributes for GDPs. Keywords: pilot questionnaire, leadership questionnaire, exploratory factor analysis, confirmatory factor analysis
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- 2015
4. Silver diamine fluoride for the management of dental caries in children in primary dental care: protocol for a feasibility study
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Timms, Laura, Rodd, Helen, Deery, Chris, Brocklehurst, Paul, and Marshman, Zoe
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- 2024
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5. Factors contributing to high performance of sows in free farrowing systems
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Baxter, Emma M., Bowers, Nicola, King, Rebecca, Brocklehurst, Sarah, and Edwards, Sandra A.
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- 2024
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6. Perinatal outcomes after admission with COVID-19 in pregnancy: a UK national cohort study
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Engjom, Hilde Marie, Ramakrishnan, Rema, Vousden, Nicola, Bunch, Kathryn, Morris, Edward, Simpson, Nigel, Gale, Chris, O’Brien, Pat, Quigley, Maria, Brocklehurst, Peter, Kurinczuk, Jennifer J., and Knight, Marian
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- 2024
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7. Silver diamine fluoride for the management of dental caries in children in primary dental care: protocol for a feasibility study
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Laura Timms, Helen Rodd, Chris Deery, Paul Brocklehurst, and Zoe Marshman
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Feasibility study ,Silver diamine fluoride ,Paediatric dentistry ,Cariology ,Caries management ,Minimally invasive caries management ,Medicine (General) ,R5-920 - Abstract
Abstract Background Dental caries remains a significant problem in England, affecting 11% of 3-year-olds and 23% of 5-year-olds. While current approaches have been extensively investigated, their ability to (1) control pain and infection; (2) prevent hospital admissions, and (3) be implemented within the National Health Service (NHS) contractual arrangements, remains unsatisfactory. Silver diamine fluoride (SDF) is an alternative, non-invasive approach that has proven efficacy in arresting caries progression in primary teeth, principally from studies conducted outside of Europe. Its use in primary dental care in the UK is limited, despite the acknowledged need. The clinical and cost-effectiveness of SDF has not been compared to usual care in the UK. Before a pragmatic randomised controlled trial (RCT) can be conducted to compare SDF to usual care for caries management in young children, there are several uncertainties that require investigation. This study aims to establish whether such an RCT is feasible. Methods This mixed-method parallel design study is a feasibility study with an embedded process evaluation, to compare SDF with usual treatment in primary dental care in the UK. It will be individually randomised, with 13 dentists and therapists, in 8 different dental primary care sites with a sample size of 80 child participants aged 1–8 years old. The aim will be to recruit ten participants per site with equal arm allocation. Follow-up will be for 1 year. The study will inform whether an RCT is feasible by resolving several key uncertainties. The acceptability and implementation of SDF and the research processes will be explored. Patient and Public Involvement and Engagement representatives will be involved throughout recruitment and retention strategies, participant documentation, analysis, engagement and dissemination. Discussion The ability to conduct an RCT will be evaluated. If feasible, this RCT has the potential to evaluate the effectiveness of a non-invasive approach for the management of untreated caries in young children. A feasibility study also offers the opportunity to consider factors associated with the implementation of SDF at an early stage through a process evaluation that will inform the definitive trial and an implementation strategy for SDF by identifying relevant barriers and facilitators. Trial registration ClinicalTrials.gov identifier: NCT06092151. Date: 19/10/2023.
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- 2024
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8. Investigating the Effectiveness of Technology-Based Distal Interventions for Postpartum Depression and Anxiety: Systematic Review and Meta-Analysis
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Sarah P Brocklehurst, Alyssa R Morse, Tegan Cruwys, Philip J Batterham, Liana Leach, Alysia M Robertson, Aseel Sahib, Colette T Burke, Jessica Nguyen, and Alison L Calear
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Computer applications to medicine. Medical informatics ,R858-859.7 ,Public aspects of medicine ,RA1-1270 - Abstract
BackgroundPostpartum anxiety and depression are common in new parents. While effective interventions exist, they are often delivered in person, which can be a barrier for some parents seeking help. One approach to overcoming these barriers is the delivery of evidence-based self-help interventions via websites, smartphone apps, and other digital media. ObjectiveThis study aims to evaluate the effectiveness of technology-based distal interventions in reducing or preventing symptoms of postpartum depression or anxiety in male and female birth and adoptive parents, explore the effectiveness of technology-based distal interventions in increasing social ties, and determine the level of adherence to and satisfaction with technology-based distal interventions. MethodsA systematic review and series of meta-analyses were conducted. Three electronic bibliographic databases (PsycINFO, PubMed, and Cochrane Library) were searched for randomized controlled trials evaluating technology-based distal interventions for postpartum depression or anxiety in birth and adoptive parents. Searches were updated on August 1, 2023, before conducting the final meta-analyses. Data on trial characteristics, effectiveness, adherence, satisfaction, and quality were extracted. Screening and data extraction were conducted by 2 reviewers. Risk of bias was assessed using the Joanna Briggs Institute quality rating scale for randomized controlled trials. Studies were initially synthesized qualitatively. Where possible, studies were also quantitatively synthesized through 5 meta-analyses. ResultsOverall, 18 articles met the inclusion criteria for the systematic review, with 14 (78%) providing sufficient data for a meta-analysis. A small significant between-group effect on depression favored the intervention conditions at the postintervention (Cohen d=–0.28, 95% CI –0.41 to –0.15; P
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- 2024
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9. Structures, processes and outcomes between first referral and referral hospitals in low-income and middle-income countries: a secondary preplanned analysis of the FALCON and ChEETAh randomised trials
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Rajeev Sharma, Neha Mishra, Simon Cousens, Sanjay Gupta, Thomas Pinkney, Neil Smart, Jonathan Cook, David Jayne, Hemanth Kumar, Peter Brocklehurst, Mohammed Bashir, Dmitri Nepogodiev, Adesoji O Ademuyiwa, Philip Alexander, Laura Magill, Mark Monahan, Rachel Moore, Stephen Tabiri, Joseph Yorke, Dion Morton, Aneel Bhangu, Bryar Kadir, Naveen Sharma, Punam Mistry, Joshua Arthur, Muneer A Malik, Tracy Roberts, Elisee Rwagahirima, Christian Urimubabo, Ewen Harrison, Vijay Kumar, Julia Brown, Pollyanna Hardy, Amit Mahajan, Pratik Solanki, James Glasbey, Himani Gupta, Omar Omar, Joana Simoes, Sivesh K Kamarajah, Adesoji Ademuyiwa, Felix Alakaloko, Olumide Elebute, Omolara Faboya, Justina Seyi-Olajide, Anita Thomas, David Lissauer, Zainab Imam, George Ihediwa, Zainab O Imam, Felix M Alakaloko, Pradeep Zechariah, Suraj Surendran, Olatunji O Lawal, Mohammed Adnan, Savleen Kaur, Faustin Ntirenganya, JC Allen Ingabire, Lawani Ismaïl, Emmy Runigamugabo, Djifid Morel Seto, Paul Wondoh, Charles Dally, Kwabena Agbedinu, Florence Dedey, Enoch Tackie, Frank Enoch Gyamfi, Anthony Davor, Akinlabi Ajao, Omobolaji Ayandipo, Olalekan Ajai, Mobolaji Oludara, Muhammad Daniyan, Danjuma Sale, Lawal Abdullahi, Olabisi Osagie, Adedeji Fatuga, Muzzammil Abdullahi, Manish Pathak, Prashant Singh, Rita Jain, Kwaku Boakye-Yiadom, Kazeem Atobatele, Ayokunle Ogunyemi, Olabode Oshodi, Christopher Bode, Omobolaji O Ayandipo, Akinlabi E Ajao, Godwin Akaba, Gabriella Hyman, Deepak Singh, Olukemi Akande, Sivesh Kathir Kamarajah, Naseem Akhtar, José A Flores, Donna Smith, Olatunji Lawal, Hadijat Olaide Raji, Zafar Khan, Matthew Francis, Emmanuel Williams, Pardeep Kumar, Oliver Samuel, María Paz Muñoz, Arun Chaturvedi, Sameer Gupta, Puneet Prakash, John Raphael, Funmilola Wuraola, Olalekan Olasehinde, Murlidhar V Pai, Deepak Jain, Anwar Sadat Seidu, Victor Ifeanyichukwu Modekwe, Jideofor Okechukwu Ugwu, Lukmon Amosu, Akan Inyang, Michael Amoah, Boateng Nimako, Dhruva Ghosh, Neil Winkles, Olabisi O Osagie, Karolin Kroese, Olubunmi Ogein, Mustapha Yakubu, Vasanth Mark Samuel, Cecil Thomas, Enono Yhoshu, Vishal Michael, William Bhatti, Swati Daniel, Jyoti Dhiman, Atul Suroy, Christopher O Bode, George C Ihediwa, Adaiah Soibi-Harry, Benedetto Osunwusi, Elizabeth Li, Sonia Mathai, Deepak Singla, Farhanul Huda, Aisha Mustapha, Anisah Yahya, Samuel Mensah, Puneet Pareek, Bernard Ofori, Souliath Lawani, Oluwafunmilayo Adeniyi, Opeyemi Rebecca Akinajo, Richard Ofosu-Akromah, Olumide Adeniyi, Adewale O. Adisa, Natacha Boumas, Fareeda Galley, Frank Enoch Gyamfi Parvez D Haque, Antonio Ramos de la Medina, Chukwuma Okereke, Ronald Tubasime, Felicity Brant, Sohini Chakrabortee, Parvez D Haque, Emily Heritage, Carmela Lapitan, Rachel Lillywhite, Pierre Sodonougbo, Pamphile Assouto, Michel Fiogbe, Houenoukpo Koco, Serge Metchinhoungbe, Hodonou Sogbo, Hulrich Behanzin, Yannick Tandje, Sosthène Kangni, Cyrile Kpangon, Marcelin Akpla, Hugues Herve Chobli, Blaise Kovohouande, Gérard Agboton, Rene Ahossi, Raoul Baderha Ngabo, Nathan Bisimwa, Covalic Melic Bokossa Kandokponou, Mireille Dokponou, Francis Moïse Dossou, Corinne Dzemta, Antoine Gaou, Roland Goudou, Emmanuel Hedefoun, Sunday Houtoukpe, Felix Kamga, Eric Kiki- Migan, Ismaïl Lawani, René Loko, Afissatou Moutaïrou, Pencome Ogouyemi, Fouad Soumanou, Pia Tamadaho, Mack-Arthur Zounon, Luke Aniakwo Adagrah, Bin Baaba Alhaji Alhassan, Mabel Pokuah Amoako-Boateng, Anthony Baffour Appiah, Alvin Asante-Asamani, Benedict Boakye, Samuel A Debrah, Donald Enti, Rahman Adebisi Ganiyu, Patience Koggoh, Richard Kpankpari, Isabella Naa M. Opandoh, Meshach Agyemang Manu, Maison Patrick Opoku Manu, Martin Tangnaa Morna, John Nkrumah, Michael Nortey, Emmanuel Owusu Ofori, Elizaberth Mercy Quartson, Esther Adjei-Acquah, Eric Agyemang Vera Agyekum, Rebecca Adjeibah Akesseh, Forster Amponsah-Manu, Ato Oppong Acquah, Leslie Issa Adam-Zakariah, Esther Asabre, Ruby Acheampong Boateng, Barbara Koomson, Ataa Kusiwaa, Emmanuel Yaw Twerefour, James Ankomah, Frank Assah-Adjei, Anthony Appiah Boakye, Godfred Fosu, Godwin Serbeh, Kofi Yeboah Gyan, Isaac Omane Nyarko, Zelda Robertson, Ralph Armah, Christopher Asare, Delali Akosua Gakpetor, Victoria Sena Gawu, Ambe Obbeng, Doris Ofosuhene, Dorcas Osei-Poku, Diana Puozaa, Arkorful Ebenezer Temitope, Regina Acquah, James Amoako, Akosua Dwamena Appiah, Mark Aseti, Charles Banka, Samuel Dadzie, Derick Essien, Romeo Hussey, Jemima Kwarteng, Naa Anyekaa Sowah, Grace Yeboah, Cynthia Yeboah, Kwame Gyambibi Addo, Enoch Appiah Akosa, Percy Boakye, Christian Larbi Coompson, Brian Gyamfi, Bismark Effah Kontor, Christian Kyeremeh, Ruth Manu, Elijah Mensah, Friko Ibrahim Solae, Gideon Kwasi Toffah, Dorcas Otuo Acheampong, Jane Acquaye, Michael Adinku, Anita Eseenam Agbeko, Emmanuel Gyimah Amankwa, George Amoah, Juliana Appiah, Alex Ayim, Emmanuel Kafui Ayodeji, Jonathan Boakye-Yiadom, Edward Amoah Boateng, Christian Kofi Gyasi-Sarpong, Naabo Nuhu Noel Hamidu, Iddrisu Haruna, Naa Kwarley, Agbenya Kobla Lovi, Bertina Beauty Nyadu, Dominic Opoku, Anita Osabutey, Robert Sagoe, Samuel Tuffour, Yaa Tufour, Francis Akwaw Yamoah, Abiboye Cheduko Yefieye, Nii Armah Adu-Aryee, Faisal Adjei, Erica Akoto, Elikem Ametefe, Joachim Kwaku Amoako, Godsway Solomon Attepor, George Darko Brown, Benjamin Fenu, Philemon Kwame Kumassah, David Olatayo Olayiwola, Theodore Wordui, Nelson Agboadoh, Fatao Abubakari, Cletus Ballu, Charles Gyamfi Barimah, Guy Casskey Boateng, Prosper Tonwisi Luri, Abraham Titigah, Frank Owusu, Raphael Adu-Brobbey, Abdul-Hamid Labaran, Junior Atta Owusu, Vivian Adobea, Amos Bennin, Fred Dankwah, Stanley Doe, Ruth Sarfo Kantanka, Ephraim Kobby, Kennedy Kofi Korankye Hanson Larnyor, Edwin Osei, Prince Yeboah Owusu, Clement Ayum Sie-Broni, Marshall Zume, Francis Atindaana Abantanga, Darling Ramatu Abdulai, Daniel Kwesi Acquah, Emmanuel Ayingayure, Imoro Osman, Sheba Kunfah, Gbana Limann, Shamudeen Alhassan Mohammed, Sheriff Mohammed, Yakubu Musah, Emmanuel Abem Owusu, Abdul-Hafiz Saba, Edwin Mwintiereh Ta-ang Yenli, Arun Gautham, Alice Hepzibah, Grace Mary, Dimple Bhatti, Karan Bir, Tapasya Dhar, Sunita Goyal, Goyal Ankush, Monika Hans, Parvez Haque, Samuel Konda, Anil Luther, Shalini Makkar, Kavita Mandrelle, Partho Mukherjee, Reuben Rajappa, Ravinder Thind, Alen Thomas, Arti Tuli, Sreejith Veetil, Esther Daniel Mark Jesudason, K Priyadarshini, Latha Madankumar, Rohin Mittal, Ida Nagomy, Rajesh Selvakumar, Bharat Shankar, Moonish Sivakumar, Rajeevan Sridhar, Devabalan Titus, Manisha Aggarwal, Parth Dhamija, Vinoth Kanna, Ashwani Kumar, Gurtaj Singh, Josy Thomas, Amos Dasari, Priya Jacob, Elizabeth Kurien, Arpit Mathew, Danita Prakash, Anju Susan, Rose Varghese, Rahul Alpheus, Ashish Choudhrie, Nitin Peters, Subrat Raul, Rakesh Vakil, Wenceslao Ángeles Bueno, Francisco Barbosa Camacho, Aldo Bernal Hernández, Ana Bogurin Arellano, Edgar Cortes Torres, Clotilde Fuentes Orozco, Erick González García de Rojas, Alejandro González Ojeda, Bertha Guzmán Ramírez, Michel Hernández Valadez, Diego Luna Acevedo, Rubén Morán Galaviz, Oscar Olvera Flores, José Pérez Navarro, Kevin Pintor Belmontes, Fernando Ramirez Marbello, Luis Ramírez-González, Laura Reyes Aguirre, Ramona Rojas García, Eduardo Valtierra Robles, Reyes Cervantes Ortiz, Gonzalo Hernandez Gonzalez, Rosa Hernandez Krauss, Luis Hernández Miguelena, Marco Hurtado Romero, Isaac Baltazar Gomez, Celina Cuellar Aguirre, Alejandro Cuevas Avendaño, Luis Dominguez Sansores, Hector Ortiz Mejia, Laura Urdapilleta Gomez del Campo, Claudia Caballero Cerdan, David Dominguez Solano, Rafael Toriz Garcia, Mariana Barreto Gallo, Ana Cortes Flores, Alejandro Gonzalez Ojeda, Monica Jimenez Velasco, Rozana Reyes Gamez, Roque Lincona Menindez, Alberto Navarrete Peón, Irani Durán Sánchez, Diana Gonzalez Vazquez, Maria Martínez Lara, Laura Martinez Perez Maldonado, Alejandra Nayen Sainz de la Fuente, Antonio Ramos De la Medina, Khadija Ado, Mohammed Aliyu, Lofty-John Anyanwu, Mahmoud Magashi, Abubakar Muhammad, Saminu Muhammad, Bello Muideen, Idris Takai, Onyekachi Ukata, Opeoluwa Adesanya, David Awonuga, Olushola Fasiku, Chidiebere Ogo, Moruf Abdulsalam, Abimbola Adeniran, Grace Eke, Esther Momson, Francisca Nwaenyi, Olufunmilade Omisanjo, Yusuf Oshodi, Yemisi Oyewole, Omotade Salami, Omolara Williams, Victoria Adeleye, Opeyemi Akinajo, David Akinboyewa, Iyabo Alasi, Oluwole Atoyebi, Olanrewaju Balogun, Orimisan Belie, Andrew Ekwesianya, Francis Ezenwankwo, Adesola Jimoh, Jubril Kuku, Oluwaseun Ladipo- Ajayi, Ayomide Makanjuola, Olayanju Mokwenyei, Samuel Nwokocha, Rufus Ojewola, Abraham Oladimeji, Thomas Olajide, Oluwaseun Oluseye, Aloy Ugwu, Ochomma Egwuonwu, Okechukwu Ekwunife, Victor Modekwe, Chukwuemeka Okoro, Chisom Uche, Kenneth Ugwuanyi, Chuka Ugwunne, Akeem Adeleke, Wilson Adenikinju, Akinfolarin Adepiti, Adewale Aderounmu, Abdulhafiz Adesunkanmi, Adewale Adisa, Samuel Ajekwu, Olusegun Ajenjfuja, Jerrie Akindojutimi, Akinbolaji Akinkuolie, Olusegun Alatise, Olubukola Allen, Micheal Archibong, Olukayode Arowolo, Deborah Ayantona, Ademola Ayinde, Olusegun Badejoko, Tajudeen Badmus, Amarachukwu Etonyeaku, Emeka Igbodike, Omotade Ijarotimi, Adedayo Lawal, Fayowole Nana, Tunde Oduanafolabi, Olaniyi Olayemi, Stephen Omitinde, Owolabi Oni, Chigozie Onyeze, Ernest Orji, Adewale Rotimi, Abdulkadir Salako, Olufemi Solaja, Oluwaseun Sowemimo, Ademola Talabi, Mohammed Tajudeen, Francis Adebayo, Oseremen Aisuodionoe- Shadrach, Lazarus Ameh, Ndubuisi Mbajiekwe, Felix Ogbo, Samson Olori, Samuel Sani Abu Sadiq, Nancy Tabuanu, Martins Uanikhoba, Godwin Chiejina, Ekpo Edet, Mary Isa, Faith Iseh, Adams Marwa, Sunday Ogbeche, Edima Olory, Gabriel Udie, Joseph Udosen, Usang Usang, Olukayode Abayomi, Rukiyat Abdus-Salam, Sikiru Adebayo, Olanrewaju Amusat, Kelvin Egbuchulem, Hyginus Ekwuazi, Peter Elemile, Taiwo Lawal, Solomon Olagunju, Peter Osuala, Bamidele Suleman, Augustine Takure, Lukman Abdur-Rahman, Nurudeen Adeleke, Muideen Adesola, Rafiat Afolabi, Sulaiman Agodirin, Isiaka Aremu, Jibril Bello, Saheed Lawal, Abdulwahab Lawal, Hadijat Raji, Olayinka Sayomi, Asimiyu Shittu, Jude Ede, Sebastian Ekenze, Vincent Enemuo, Matthew Eze, Uchechukwu Ezomike, Emmanuel Izuka, Okezie Mbadiwe, Ngozi Mbah, Uba Ezinne, Iweha Ikechukwu, Okoi Nnyonno, Philemon Okoro, Igwe Patrick, Oriji Vaduneme, Abhulimen Victor, Salathiel Kanyarukiko, Francine Mukaneza, Deborah Mukantibaziyaremye, Aphrodis Munyaneza, Gibert Ndegamiye, Ronald Tubasiime, Moses Dusabe, Emelyne Izabiriza, Hope Lydia Maniraguha, Christophe Mpirimbanyi, Josiane Mutuyimana, Olivier Mwenedata, Francine Uwizeyimana, Job Zirikana, Aime Dieudonne Hirwa, Elysee Kabanda, Salomee Mbonimpaye, Christine Mukakomite, Piolette Muroruhirwe, Georges Bucyibaruta, Gisele Juru Bunogerane, Sosthene Habumuremyi, Jean de Dieu Haragirimana, Alphonsine Imanishimwe, Violette Mukanyange, Emmanuel Munyaneza, Emmanuel Mutabazi, Isaie Ncogoza, Jeannette Nyirahabimana, Mary Augusta Adams, Richard Crawford, Chikwendu Jeffrey Ede, Maria Fourtounas, Morapedi Kwati, Mpho Nosipho Mathe, Ncamsile Anthea Nhlabathi, Hlengiwe Samkelisiwe Nxumalo, Paddy Pattinson, Nnosa Sentholang, Mmule Evelyn Sethoana, Maria Elizabeth Stassen, Laura Thornley, Cheryl Birtles, Mathete Ivy, Cynthia Mbavhalelo, Zain Ally, Abdus-sami Adewunmi, Maria Picciochi, Michael Bahrami-Hessari, Didier Ahogni Benin, Aristide Ahounou, K. Alassan Boukari, Oswald Gbehade, Thierry K Hessou, Sinama Nindopa, M.J. Bienvenue Nontonwanou, Nafissatou Orou Guessou, Arouna Sambo, Sorekou Victoire Tchati, Affisatou Tchogo, Semevo Romaric Tobome, Parfait Yanto, Isidore Gandaho, Armel Hadonou, Simplice Hinvo, Montcho Adrien Hodonou, Sambo Bio Tamou, Marie-Claire Kouroumta, Enrif Malade, Anne stredy Mkoh Dikao, Joel Nzuwa Nsilu, Nathan Bisimwa Mitima, Cyrille Kpangon, Stephane Laurent Loupeda, Mamonde Victorin Agbangla, Sena Emmanuel Hedefoun, Thierry Mavoha, Juvenal Ngaguene, Janvier Rugendabanga, Rish Romaric Soton, Martin Totin, Mouhamed Agbadebo, Irene Akpo, Hubert Dewamon, Martin Djeto, Aissatou Hada, Monsede Hollo, Albert Houndji, Anasthasie Houndote, Sylvestre Hounsa, Expedit Kpatchassou, Hugues Yome, Mohamed Moussa Alidou, Bonheur Dossou Yovo, Robert Guinnou, Souleymane Hamadou, Nabil Moussa, Boniface Cakpo, Lolyta Etchisse, Emery Hatangimana, Moise Muhindo, Katia Sanni, Agossou Barthelemy Yevide, Hermann Agossou, Fiston Basirwa Musengo, Bill Armstrong Alia, Arnaud Alitonou, Lucien Agbanda, Julien Attinon, Marcel Gbassi, Nounagnon Rene Hounsou, Derick Esssien, Yakubu Mustapha, Kojo Nunoo-Ghartey, Luke A Aniakwo, Margarey N M Adjei, Yvonne Adofo-Asamoah, Meshach M Agyapong, Thomas Agyen, Baba A B Alhassan, Mabel P Amoako-Boateng, Josephine Ashong, Joseph K Awindaogo, Benjamin B Brimpong, Makafui S C J K Dayie, Wendy W Ghansah, Jude E Gyamfi, Vincent Kudoh, Philip Mensah, Isabella N Morkor Opandoh, Martin T Morna, Emelia Odame, Emmanuel O Ofori, Sandra Quaicoo, Elizabert M Quartson, Cynthia Teye-Topey, Makafui Yigah, Safia Yussif, Vera O Agyekum-Gyimah, Eric Agyemang, Arko Akoto- Ampaw, Temitope E Arkorful, Moses A Dokurugu, Nanabanyin Essel, Aja Ijeoma, Emmanuel L Obiri, Karen N D Quarchey, Leslie Adam-Zakariah, Aaron B Andoh, Ruby A Boateng, Atta Kusiwaa, Adeline Naah, Ato Oppon-Acquah, Benjamin A Oppong, Emma A Agbowada, Ameley Akosua, O Lawrence Dorcas Acheampong, Frank E Gyamfi, Bertina B Nyadu, Samira Abdulai, Nii A Adu-Aryee, Joachim K Amoako, Nicholas T Aperkor, Wilfred K Asman, Godsway S Attepor, Antoinette A Bediako-Bowan, George D Brown, Victor K Etwire, Benjamin S Fenu, Philemon K Kumassah, Linda A Larbi-Siaw, Josephine Nsaful, David O Olatola, Sandra E Tsatsu, Iddrisu I A Abdul-Aziz, Johnson Akunyam, Gilbert A G Anasara, Charles G Barimah, Guy C Boateng, Ponala W Kwabena, Seidu M Kwarteng, Prosper T Luri, Kennedy Ngaaso, David K D Ogudi, Collins Kyeremeh, Clement Sie-Broni, Saba Abdul-Hafiz, Daniel K Acquah, Shamsudeen M Adams, Mohammed S Alhassan, Munira Amadu, Samuel A Asirifi, Martin Awe, Millicent Azanlerigu, Mathias K Dery, Yenli Edwin, Abantanga Atindaana Francis, Aloysius Maalekuu, Hawa Malechi, Ibrahim Mohammed, Kareem Mumuni, Bernard A Ofori, Jonathan I K Quansah, Napoleon Bellua Sam, Anwar S Seidu, Shekira Yahaya, Emmanuel Kojo Acquah, Jaabir Alhassan, Christian L Coompson, Addo K Gyambibi, Ametepe Jeffery-Felix, Bismark E Kontor, Gifty Naah, Carmen Noufuentes, Abraham Sakyi, Ramkaran Chaudhary, Sanjeev Misra, Dharma R Poonia, Kirti K Rathod, Mahaveer S Rodha, Nivedita Sharma, Subhash C Soni, Vaibhav K Varsheney, Jeevan R Vishnoi, Deepak K Garnaik, Manoj J Lokavarapu, Rohit Ranjan, Rajkumar K Seenivasagam, Shanky Singh, Raunak Verma, Suzan John, Jeffery A Kalyanapu, Ananta Kutma, Sanish Philips, Arun K Gautham, Deepak S Singh, Eunice S Abraham, Chetana Chetana, Prashant Dummala, Chinta S Gold, Jurgen Jacob, Jeremiah N Joseph, Elizabeth N Kurien, Priya Mary, Arpit J Mathew, Amy E Mathew, Danita D Prakash, Ashwin Sukumar, Niyah Syam, Alisha Bhatt, Dhruva N Ghosh, Ankush Goyal, Monika A Hans, Jyoti Jyoti, Karan Kumar, Vivin Daniel Sam, Ravinder Singh Thind, Sreejith K Veetil, Rahul Williams, D Sreekar, Esther R Daniel, Smitha E Jacob, Mark R Jesudason, Pushplatha Kumari, Soosan Prasad, Srujan Sharma, Moonish V Sivakumar, Paul Trinity, Sudheer Kanchodu, K Leshiini, Sundeep S Saluja, Ashok K Attri, Ishan Bansal, Monika Gureh, Simran Kapoor, Harmanjot Kaur, Simrandeep Singh, Viju John, Nivesh Agrawal, Uttkarsh Kumar, S Abhishek, Vikram Sehrawat, Gaurav Thami, Stanley Mathew, P S Prabhu, P T Sundeep, Shiv Rajan, Mohit Singh, Abhilasha Tripathi, Philip V Alexander, A Vijay, Moloti Kichu* Ismavel, Carolin V Solomi, Rahul A Alpheus, Ashish Victor Choudhrie, Rashmi Jacob Gunny, Susan Joseph, Nitin J Peters, Neha Pundir, Ram Samujh, Hafsa I Ahmed, Gowhar Aziz, Nisar A Chowdri, Rayees A Dar, Robindera Kour, Imtiyaz Mantoo, Asif Mehraj, Fazl Q Parray, Najmus Saqib, Zamir A Shah, Rauf A Wani, Komal Rautela, Nishu Singh, Priyanka Chowdhury, Sona Chowdhury, Pragyanmai Nayak, Bipradas Roy, Andrea S Alvarez Villaseñor, Kriscia V Ascencio Díaz, Victor J Avalos Herrera, Francisco J Barbosa, Elyoenai Bonilla Ahumada, Irma V Brancaccio, Miguel A Calderón, Guadalupe Castillo Cardiel, Guillermo A Cervantes, Gabino Cervantes Guevara, Enrique Cervantes Perez, Maria Chávez, Jonathan M Chejfec, Luis R Cifuentes, Ana O Cortés, Edgar J Cortes, Tania A Cueto, Andrea E Cueto, Esteban Cueva Martinez, Paulina Domínguez Barradas, Isaac Esparza Estrada, Paola Flores Becerril, Luis A García, Benjamín García Reyna, Eduardo Gómez Sánchez, Jaime L González, Eduardo González Espinoza, Fanny Y González, Cristhian S Guerrero, José A Guzmán, Bertha G Guzmán, Mario J Guzmán, DanielA Hérnandez Alva, SilviaA Ibarra Camargo, JuanC Ibarrola Peña, Martin Islas Torres, Jorge Jiménez Tornero, ZayraM Lara Pérez, Roberto Mares País, MelP Mellado Tellez, RobertoC Miranda Ackerman, Damián Mora Santana, Gilberto Morgan Villela, Rodrigo Nájar Hinojosa, Cesar Nuño Escobar, Itzel Ochoa Rodríguez, Angelica Ortega Barreiro, Jacqueline Osuna Rubio, Luis RPacheco Vallejo, VíctorH Pérez Bocanegra, JoseV Pérez Navarro, Francisco JPlascencia Posada, MaríaA Quirarte Hernández, LuisR Ramirez Gonzalez, Emilio AReyes Elizalde, EveliaV Romo Ascencio, Cornelio Ruelas Bravo, CarlosB Ruiz Velasco, JoséA Sánchez Martínez, Guillermo Sanchez Villaseñor, JoséI Sandoval Pulido, AlejandroG Serrano García, LuisO Suárez Carreón, JuanJ Tijerina Ávila, JesusO Vega Gastelum, MelissaL Vicencio Ramirez, MariaF Zarate Casas, CarlosJ Zuloaga, Fernández del Valle, JesusAntonion Aguilar Mata, MiguelAntonio Calderon Vanegas, RocioGuadalupe Cano Arias, Carlos Colunga Tinajero, Fernanda Diaz Samano, Fernando Duque Zepeda, BrendaVanessa Enriquez Barajas, Gerardo Gallardo Banuelos, MarijoseDe CristoGonzalez Calvillo, Francisco Ibanez Ortiz, Maryzela Lazo Ramirez, Gerardo Lopez Arroyo, LauraOlivia Montano Angeles, DavidGiovannyI Morales Iriarte, AngeloFernando Mortola Lomeli, Jose EstebanOrozco Navarro, Jaime Orozco Perez, Damaris Orozco Ramirez, LauraGabriela Pena Baolboa, Jesus Pizarro Lozano, Guillermo Yanowsky Reyes, Monica N Castillo, Ana CamilleG Dominguez, Dorihela H Mellado, Jesus FlavioM Morales, Luzdel CarmenM Namur, Jose AlbertoA Pesquera, LauraMartinez Perez Maldonado, Antonio RamosDe laMedina, Katya Bozada-Gutierrez, AnaFlorencia Casado-Zarate, Roberto Delano-Alonso, Jose Herrera-Esquivel, Mucio Moreno-Portillo, Mario Trejo-Avila, Roland Kevin CethorthFonseca, Edgard Efren LozadaHernandez, Bruno Crocco Quiros, JairoArturo Rodriguez Ramirez, Gabriela Ambriz-González, MitziR Becerra Moscoso, Ishtar Cabrera-Lozano, AnaB Calderón-Alvarado, FranciscoJ León-Frutos, ErickE Villanueva-Martínez, Aisha Abdullahi, Maimuna Abubakar, MohammedS Aliyu, Mudi Awaisu, Fadimatu Bakari, Abigail Olajumoke Balogun, Ahmad Bello, Kehinde Michael Duromola, Stephen G Gana, Mukoro Duke George, Justina Gimba, Isaac Gundu, Lambert Onahi Iji, Aminat O Jimoh, Afolabi K Koledade, Ahmad T Lawal, Bilkisu K Lawal, Stanley Emeka Nwabuoku, Oluseyi O Ogunsua, Ifeanyi Fidelis Okafor, Ethos Ike Okorie, Nasir Oyelowo, Ibrahim A Saidu, Tunde T Sholadoye, Ibrahim Sufyan, Musliu Adetola Tolani, Aliyu Muhammad Tukur, Ahmad Shehu Umar, Aminatu M Umar, Hajara Umaru-Sule, Mohammed Usman, Alfa Yakubu, Salisu Abeku Yusuf, Abdulhafiz A Abdulkarim, Lawal Barau Abdullahi, Khadija A Ado, Nura U Aliyu, Lofty-John Chukwuemeka Anyanwu, Sulaiman M Daneji, Mahmoud Kawu Magashi, Mohammad A Mohammad, Abubakar Bala Muhammad, Saminu S Muhammad, Bello Abodunde Muideen, Calistus U Nwachukwu, Suleiman B Sallau, Abdulrahman A Sheshe, Abdulmajeed Soladoye, Idris Usman Takai, Garzali I Umar, Abubakar Yahaya, Lubabatu Abdulrasheed, Joel A Adze, Lydia R Airede, Bashiru Aminu, Stephen B Bature, Firdaws Bello-Tukur, Damai Chinyio, SharonA N Duniya, Moses C Galadima, Babatunde K Hamza, Samaila Joshua, Stephen A Kache, Williams Y Kagomi, Ifeanyi A Kene, Jamila Lawal, Jerry G Makama, Caleb Mohammed, Amina A Mohammed-Durosinlorun, Deborah Nuwam, Abdulrasheed Sani, Salome Tabara, Mathew C Taingson, Emmanuel Usam, Josiah Yakubu, Folasade Adegoke, Oluwasuyi Ige, Tunde A Odunafolabi, Chukwuma E Okereke, Oluwafemi O Oladele, Oluwaseun H Olaleye, Oyetunde O Olubayo, Olukayode P Abiola, Henry O Abiyere, Idowu O Adebara, GbadeboT C Adeleye, Adebayo A Adeniyi, Olumide E Adewara, Olabisi T Adeyemo, Ademola A Adeyeye, Abimbola L Ariyibi, Babatunde S Awoyinka, Olumide M Ayankunle, Olakunle F Babalola, Adewumi Bakare, TajudeenI B Bakare, Oluseyi O Banjo, Peter A Egharevba, Oluwafemi S Fatudimu, John A Obateru, Oluremi J Odesanya, Owolabi D Ojo, Abiodun I Okunlola, Cecilia K Okunlola, Adewale T Olajide, Tesleem O Orewole, Adedayo I Salawu, Moruf A Abdulsalam, Aderinsola T Adelaja, Olalekan T Ajai, Noble Anyanwu, Kazeem M Atobatele, Oludayo Oluwaseyi Bakare, Omolara M Faboya, Francisca C Nwaenyi, Ayokunle A Ogunyemi, Mobolaji A Oludara, Olufunmilade A Omisanjo, Chinonso U Onyeka, Olabode A Oshodi, Yusuf A Oshodi, Omotade S Salami, Omolara M Williams, Esther Abunimye, Adebunmi Adeoluwa, Adedotun Adesiyakan, Victoria Ibukunoluwa Adeyeye, Moses Vincent Agbulu, David O Akinboyewa, Iyabo O Alasi, Michael Amao, Christiana Ashley-Osuzoka, Oluwole A Atoyebi, Olanrewaju S Balogun, Maryam Oluwatobi Busari, Nnamdi Jonathan Duru, Glory Bassey Edet, Olumide A Elebute, Francis Chinonso Ezenwankwo, Adedeji L Fatuga, Christianah Gbenga-Oke, Emmanuel Sylvester Inyang, Adesola I Jimoh, Jubril Oladayo Kuku, OluwaseunA Ladipo-Ajayi, Abdulrazzaq O Lawal, Christian Chigoze Makwe, Chinelo Victoria Mgbemena, Samuel U Nwokocha, Moses Adebisi Ogunjimi, Ephraim Okwudiri Ohazurike, Rufus W Ojewola, Moyosoluwa Eunice Badedale, Chike J Okeke, Adeyemi A Okunowo, Abraham T Oladimeji, Thomas O Olajide, Olabisi Olanrewaju, Olawunmi Olayioye, Oluwaseun O Oluseye, Stephen Olutola, Kenneth Onyekachi, Adeola Ayoola Orowale, Emili Osariemen, Adedapo Olumide Osinowo, Emmanuel Owie, Christianah Bidemi Oyegbola, Justina OSeyi-Olajide, AdaiahP Soibi-Harry, Manuella Talla Timo, Aloy Okechukwu Ugwu, Emmanuel Ojo Williams, Innocent O Duruewuru, Ochonma A Egwuonwu, Okechukwu Hyginus Ekwunife, James J Emeka, Chimdiebele Daisy Nwosu, Sylvester O Obiechina, Ahuizechukwu E Obiesie, Celestine I Okafor, Theophilus O Okonoboh, Odili A Okoye, Onyekachi A Onu, Chukwudubem C Onyejiaka, Chisom Faith Uche, JosephO Ugboajah, Akeem A Adeleke, Akinfolarin C Adepiti, Adewale A Aderounmu, Abdulhafiz O Adesunkanmi, Adewale O Adisa, Samuel C Ajekwu, Olusegun K Ajenifuja, Olusegun I Alatise, Tajudeen A Badmus, Tajudeen O Mohammed, Abdulkadir A Salako, Oludayo A Sowande, Ademola O Talabi, Funmilola O Wuraola, Paul Aderemi Adegoke, Abidemi Akinloye, Ayodeji Akinniyi, Joseph Ejimogu, Ideyonbe Samuel Eseile, Olakayode Olaolu Ogundoyin, Amos Okedare, Dare Isaac Olulana, Omolara Omotola, Francis Sanwo, Collins C Adumah, Adewale O Ajagbe, Olugbenga P Akintunde, Opeyemi Q Asafa, Kehinde Awodele, Amogu K Eziyi, Adeniyi O Fasanu, Olufemi O Ojewuyi, Abiodun R Ojewuyi, Abisola E Oyedele, Oluwaseun A Taiwo, Habiba I Abdullahi, Nathaniel D Adewole, Teddy E Agida, Eunice E Ailunia, Oseremen Aisuodionoe-Shadrach, Godwin O Akaba, Janet Alfred, Terkaa Atim, Kehinde G Bawa, John Y Chinda, Esther B Daluk, Sefiu B Eniola, Augusta O Ezenwa, Stephen E Garba, Philip M Mshelbwala, Ngozi O Ndukwe, Idoko P Ogolekwu, Alexander A Ohemu, Samuel A Sani, Salisu Suleiman, Helen Sunday, Nancy O Tabuanu, Aminu M Umar, Peter I Agbonrofo, Alexander I Arekhandia, Morrison E Edena, Raymond A Eghonghon, Joel E Enaholo, Genesis Ida, Stanley N Ideh, Oseihie I Iribhogbe, Omorodion O Irowa, Maradona E Isikhuemen, Oluwatomi R Odutola, Kester O Okoduwa, Scott O Omorogbe, David Oruade, Osasumwen T Osagie, Osarenkhoe Osemwegie, RukiyatA Abdus-Salam, Sikiru Adekola Adebayo, Oluwasanmi A Ajagbe, Gboyega Ajibola, Kelvin I Egbuchulem, Hyginus O Ekwuazi, Adegbolahan Fakoya, Oluwasegun C Idowu, David O Irabor, Taiwo A Lawal, Olakayode O Ogundoyin, Oluwabukade Ojediran, Naomi Olagunju, Akinsola T Sanusi, Augustine O Takure, Lukman Olajide Abdur-Rahman, Mary Oluwadamilola Adebisi, Nurudeen Abiola Adeleke, Rafiat Tinuola Afolabi, Isiaka Ishola Aremu, Jibril Oyekunle Bello, Robiat Bello, Saheed Abolade Lawal, Adeolu Ojajuni, Sabur Oyewale, Victor Abhulimen, Patrick O Igwe, Ikechukwu Enyinnaya Iweha, Raphael E John, Nnyonno Okoi, Philemon E Okoro, Vaduneme Kingsley Oriji, Ibiene T Oweredaba, Japhet Mizero, Immaculee Mutimamwiza, Francoise Nirere, Irenee Niyongombwa, Jean Paul Majyabere, Anastase Byaruhanga, Rongin Dukuzimana, Jean Aimable Habiyakare, Marie Gloriose Nabada, Marcel Uwizeye, Mathias Ruhosha, Joselyne Igiraneza, Faustine Ingabire, Aloys Karekezi, Jean pierre Masengesho, Lydia Mukamazera, Clemence Mukangabo, Jean Paul Niyomuremyi, Gabriel Ntwari, Celestin Seneza, Divine Umuhoza, Pierrine Nyirangeri, Jean Claude Uwimana, Isaie Sibomana, Desire Rubanguka, Josine Umuhoza, Roda Uwayezu, Leoncie Uzikwambara, Herbert Butana, Moise Dusabeyezu, Athanasie Mukasine, Jean N Utumatwishima, Mediatrice Batangana, Jeande Dieu Haragirimana, AllenJ C Ingabire, Espoir Mwungura, Dancilla Nyirasebura, Christian Jean Urimubabo, Anaclet Dusabimana, Sam Kanyesigye, Robert Munyaneza, Jean Yves Shyirakera, Aimee Domingo, Philip Munda, Chido Nyatsambo, Victor Ojo, Rudo Pswarayi, and Soeren Laurberg
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Medicine (General) ,R5-920 ,Infectious and parasitic diseases ,RC109-216 - Published
- 2024
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10. Feasibility of using contrast-free quantitative magnetic resonance imaging for liver sparing stereotactic ablative body radiotherapy
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Frank Brewster, Zoe Middleton, Alan McWilliam, Andrew Brocklehurst, Ganesh Radhakrishna, and Robert Chuter
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Biologically-guided radiotherapy ,Liver cancer ,Functional MR ,Quantitative imaging ,SABR ,Liver sparing ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background and purpose: Tumours in the liver often develop on a background of liver cirrhosis and impaired liver function. As a result, radiotherapy treatments are limited by radiation-induced liver disease, parameterised by the liver mean dose (LMD). Liver function is highly heterogeneous, especially in liver cancer, but the use of LMD does not take this into account. One possible way to improve liver treatments is to use quantitative imaging techniques to assess liver health and prioritise the sparing of healthy liver tissue. Materials and methods: Anatomical T2 and quantitative iron-corrected T1 (cT1) images were made available for 10 patients with liver metastases. Functional liver volumes were automatically segmented on the quantitative images using a threshold. Liver stereotactic ablative body radiotherapy (SABR) plans were made using a departmental protocol. Liver-sparing plans were then made by reducing the dose to the functional sub-volume. Results: The sparing plans achieved a statistically significant (p=0.002) reduction in the functional liver mean dose, with a mean reduction of 1.4 Gy. The LMD was also significantly different (p=0.002) but had a smaller magnitude with a mean reduction of 0.7 Gy. There were some differences in the planning target volume D99% (p=0.04) but the sparing plans remained within the optimal tolerance and the D95% was not significantly different (p=0.2). Conclusions: This study has, for the first time, demonstrated the use of cT1 maps in radiotherapy showing significant reductions in dose to the healthy liver. Further work is needed to validate this in liver cancer patients, who would likely benefit most.
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- 2024
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11. Impact of motion management strategies on abdominal organ at risk delineation for magnetic resonance-guided radiotherapy
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Mairead Daly, Lisa McDaid, Carmel Anandadas, Andrew Brocklehurst, Ananya Choudhury, Alan McWilliam, Ganesh Radhakrishna, and Cynthia L. Eccles
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Motion management ,MR-guided radiotherapy ,SABR ,SBRT ,IGRT ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background and purpose: The impact of respiratory motion management strategies for abdominal radiotherapy, such as abdominal compression (AC) and breath hold (BH), on abdominal organ at risk (OAR) delineation on magnetic resonance imaging (MRI) is unknown. This feasibility study compared the inter- and intra- observer delineation variation on MRI acquired with AC, BH for three critical abdominal OAR. Materials and methods: T2-weighted (W) 3D MRI in free-breathing (FB) and with AC, and T1W 3D mDixon exhale BH were acquired. Four observers blinded to motion management strategy used, delineated stomach, liver, and duodenum on all MRI. One case per strategy was repeated over 6 weeks later to quantify intra-observer variation. Simultaneous truth and performance level estimation (STAPLE) contours for each OAR were generated, median and IQR mean distance to agreement (mDTA) and maximum Hausdorff distance (HD) between observer and STAPLE contours were calculated. Observers scored organ visibility on each MRI using a four-point Likert scale. Results: A total of 27 scans including repeats were delineated. Pooled mDTA for all OARs was 1.3 mm (0.5 mm) with AC, 1.4 mm (1.0 mm) with BH, and 1.3 mm (0.5 mm) in FB. Intra-observer mDTA was highest for all organs in FB with 10.8 mm for duodenum, 1.8 mm for liver, and 2.7 mm for stomach. The pooled mean perceptual quality score value was highest for AC across organs. Conclusions: No motion management strategy demonstrated superior similarity across OAR, emphasizing the need for personalised approaches based on individual clinical and patient factors.
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- 2024
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12. Improving children’s oral health in Wales through partnership
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Mary Wilson, Paul Brocklehurst, Andrew John Dickenson, and Anwen Cope
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Pediatrics ,RJ1-570 - Published
- 2024
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13. Incidence and outcomes of vasa praevia in the United Kingdom [version 1; peer review: 2 approved, 1 approved with reservations, 1 not approved]
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Ruth Tunn, Anna L David, Marian Knight, Peter Brocklehurst, and George Attilakos
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Vasa praevia ,incidence ,outcomes ,perinatal mortality ,velamentous cord insertion ,pregnancy ,eng ,Medicine - Abstract
Background Vasa praevia is an obstetric condition in which the fetal vessels run through the membrane over the internal cervical os, unprotected by the placenta or umbilical cord. It is associated with perinatal mortality if not diagnosed antenatally. We investigated the incidence and outcomes of vasa praevia in the UK. Methods We conducted a population-based descriptive study using the UK Obstetric Surveillance System (UKOSS). Cases were identified prospectively through monthly UKOSS submissions form all UK hospitals with obstetrician-led maternity units. All women diagnosed with vasa praevia who gave birth between 1st December 2014 and 30th November 2015 were included. The main outcome was incidence of vasa praevia with 95% confidence intervals, using 2015 maternities as the denominator. Results Fifty-one women met the case definition. The incidence of diagnosed vasa praevia was 6.64 per 100,000 maternities (95% CI 5.05-8.73). Of 198 units, 10 (5%) had a vasa praevia screening programme; one of these 10 units identified 25% of the antenatally diagnosed cases. Among women who had vasa praevia diagnosed or suspected antenatally (n=28, 55%), there were no perinatal deaths or hypoxic ischaemic encephalopathy (HIE). Twenty-four women with antenatal diagnosis were hospitalised at a median gestation of 32 weeks and caesarean section was scheduled at a median gestation of 36 weeks. When vasa praevia was diagnosed peripartum (n=23, 45%), the perinatal mortality rate was 37.5% and 47% of survivors developed HIE. Conclusions The incidence of diagnosed vasa praevia was lower than anticipated. There was high perinatal mortality and morbidity for cases not diagnosed antenatally. The incidence of antenatally identified cases was much higher in the few centres that actively screened for this condition, and the perinatal outcomes were better. However, this group were all delivered by caesarean section and may include women who would not have experienced any adverse perinatal outcome.
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- 2024
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14. Home-based EXercise and motivAtional programme before and after Liver Transplantation (EXALT): study protocol for phase II two-centre, randomised controlled trial
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Gemma Slinn, Peter Brocklehurst, Clare Melikian, Chiemelie Ngonadi, Yongzhong Sun, Samir Mehta, Francesca Gowing, Alice Freer, Wendy Osborne, Karen Rockell, Nicholas Adams, Sukhwant Sehmi, Matthew J. Armstrong, Sharon Augustt, Shahida Begum, Liam Botfield, Dawn Brant, Emily Clibbens, Nigel Cope, Joan L. Duda, Sally A.M. Fenton, David J. Garside, Ashlea Hargreaves, William Leach, Daniel S. Martin, Don Milliken, Sonia Murray, Christian Price, Felicity R. Williams, and Shu Xiaoyi
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Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Introduction Physical frailty is associated with increased mortality and poor quality of life (QoL) before and after liver transplantation (LT). Evidence is lacking on how to tailor exercise and behavioural techniques in this patient population.Methods and analysis Home-based EXercise and motivAtional programme before and after Liver Transplantation (EXALT) is a phase 2b, open-label, two-centre randomised controlled clinical trial designed to investigate whether a remotely monitored ‘home-based exercise and theory-based motivation support programme (HBEP)’ before and after LT improves QoL in LT recipients. Adult patients awaiting a primary LT will be assessed for eligibility at two LT centres (Birmingham, Royal Free London). Participants will be randomly assigned (1:1) to receive either an HBEP while on the LT waiting list through to 24 weeks after LT (Intervention) or a patient exercise advice leaflet (Control). Using a standard method of difference in means (two-sided significance level 0.05; power 0.90) and accounting for a 35% attrition/withdrawal rate, a minimum of 133 patients will be randomised to each treatment group. The primary outcome measure will be assessed using intention-to-treat analysis of the difference in the Physical Component Score of Short form-36 version 2.0 health-related QoL questionnaire between the groups at 24 weeks post-LT.Ethics and dissemination The protocol was approved by the South Central-Hampshire A National Research Ethics Committee. Recruitment into the EXALT trial started in May 2022 and is due to end in June 2024, with 217/266 patients randomised to date. The intervention follow-up is due to finish in May 2026. The findings of this trial will be disseminated through peer-reviewed publications, conferences and social media.Trial registration number ISRCTN13476586.
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- 2024
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15. Factors contributing to high performance of sows in free farrowing systems
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Emma M. Baxter, Nicola Bowers, Rebecca King, Sarah Brocklehurst, and Sandra A. Edwards
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Animal culture ,SF1-1100 ,Veterinary medicine ,SF600-1100 - Abstract
Abstract Background Pressure to abolish farrowing crates is increasing, and producers are faced with decisions about which alternative system to adopt. For sow welfare, well designed free farrowing systems without close confinement are considered optimal but producers have concerns about increased piglet mortality, particularly crushing by the sow. Reporting accurate performance figures from commercial farms newly operating such systems could inform the transition process. This study investigated performance on three commercial farms operating four different zero-confinement systems, three of which were newly installed. A total of 3212 litters from 2920 sows were followed from farrowing to weaning over a three-year period with key performance indicators (KPIs) recorded. Mixed Models (LMMs, GLMMs) determined the influence of different factors (e.g. farrowing system, sow parity, management aspects) and litter characteristics on performance, including levels and causes of piglet mortality. Results Piglet mortality was significantly influenced by farm/system. Live-born mortality ranged from 10.3 to 20.6% with stillbirths ranging from 2.5 to 5.9%. A larger litter size and higher parity resulted in higher levels of mortality regardless of system. In all systems, crushing was the main cause of piglet mortality (59%), but 31% of sows did not crush any piglets, whilst 26% crushed only one piglet and the remaining sows (43%) crushed two or more piglets. System significantly influenced crushing as a percentage of all deaths, with the system with the smallest spatial footprint (m2) compared to the other systems, recording the highest levels of crushing. Time from the start of the study influenced mortality, with significant reductions in crushing mortality (by ~ 4%) over the course of the three-year study. There was a highly significant effect of length of time (days) between moving sows into the farrowing accommodation and sows farrowing on piglet mortality (P
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- 2024
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16. Perinatal outcomes after admission with COVID-19 in pregnancy: a UK national cohort study
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Hilde Marie Engjom, Rema Ramakrishnan, Nicola Vousden, Kathryn Bunch, Edward Morris, Nigel Simpson, Chris Gale, Pat O’Brien, Maria Quigley, Peter Brocklehurst, Jennifer J. Kurinczuk, and Marian Knight
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Science - Abstract
Abstract There are few population-based studies of sufficient size and follow-up duration to have reliably assessed perinatal outcomes for pregnant women hospitalised with SARS-CoV-2 infection. The United Kingdom Obstetric Surveillance System (UKOSS) covers all 194 consultant-led UK maternity units and included all pregnant women admitted to hospital with an ongoing SARS-CoV-2 infection. Here we show that in this large national cohort comprising two years’ active surveillance over four SARS-CoV-2 variant periods and with near complete follow-up of pregnancy outcomes for 16,627 included women, severe perinatal outcomes were more common in women with moderate to severe COVID-19, during the delta dominant period and among unvaccinated women. We provide strong evidence to recommend continuous surveillance of pregnancy outcomes in future pandemics and to continue to recommend SARS-CoV-2 vaccination in pregnancy to protect both mothers and babies.
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- 2024
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17. Dilution of broiler breeder diets with oat hulls prolongs feeding but does not affect central control of appetite
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Laura M. Dixon, Sarah Brocklehurst, Joe Hills, Simone Foister, Peter W. Wilson, Angus M.A. Reid, Sarah Caughey, Victoria Sandilands, Tim Boswell, Ian C. Dunn, and Rick B. D'Eath
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broiler breeder ,feed restriction ,behavior ,motivation ,AGRP ,Animal culture ,SF1-1100 - Abstract
ABSTRACT: The parents of broiler (meat) chickens (ie, broiler breeders) are food-restricted until sexual maturity, ensuring good health and reproduction, but resulting in hunger. We investigated whether diets with added insoluble fiber promote satiety and reduce behavioral, motivational, and physiological signs of hunger. Ninety-six broiler breeders were fed 1 of 4 feed treatments (n = 24 per diet) from 6 to 12 wk of age: 1) a commercial diet fed to the recommended ration (R) or 2) ad libitum (AL), the same diet as R but mixed with oat hulls at 3) 20% (OH20%) or 4) 40% (OH40%). The R, OH20% and OH40% diets were approximately iso-energetic and resulted in mean 12 wk of age weights within 2.5% of each other (1.21 kg), while AL birds weighed 221% as much (2.67kg). At 12 wk of age, agouti-related protein (AGRP) expression, was, on average, more than 12 times lower in AL birds (P < 0.001) but did not differ between the fiber diet treatments and R. Pro-opiomelanocortin (POMC) expression, was, on average, over 1.5 times higher in AL birds, but was not statistically significantly affected by feed treatments (P = 0.33). In their home pens, AL birds stood/sat more, foraged less and fed more in total (P < 0.001) and OH40% birds spent longer feeding than R (P = 0.001). Motivation to forage tested by willingness to walk through water to access an area of wood shavings (without food) was not significantly affected by diet (P = 0.33). However, restricted birds were willing to cross in only 7.3% to 12.5% of tests. Mostly birds stayed on the start platform, where AL birds sat more than other treatments and OH40% birds reduced walking relative to R birds (P = 0.016). Across the behavioral and physiological measurements there was a dichotomy of effects in response to approximately iso-energetic diets differing in fiber. There were some potentially beneficial behavioral effects related to reduced foraging and walking. However, there was no evidence that these diets significantly improved physiological measures of satiety of broiler breeders.
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- 2024
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18. Cerclage suture type to prevent pregnancy loss in women requiring a vaginal cervical cerclage: the C-STICH RCT
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Victoria Hodgetts Morton, Catherine A Moakes, Jane Daniels, Lee Middleton, Andrew Shennan, Peter Brocklehurst, Fidan Israfil-Bayli, Andrew K Ewer, James Gray, Nigel AB Simpson, Jane E Norman, Christoph Lees, Konstantinos Tryposkiadis, Clive Stubbs, Max Hughes, R Katie Morris, and Philip Toozs-Hobson
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pregnancy ,pregnancy trimester ,second trimester miscarriage ,premature birth ,sutures ,vaginal cervical cerclage ,randomised controlled trial ,Medical technology ,R855-855.5 - Abstract
Background Second trimester miscarriage and preterm birth is a significant global problem. Surgical cervical cerclage is performed to prevent pregnancy loss and preterm birth. It utilises either a monofilament or braided suture. It is hypothesised that a braided material becomes colonised with pathogenic bacteria that causes vaginal dysbiosis, infection and cerclage failure. Objectives The primary objective of the study was to examine the effectiveness of using a monofilament suture material as opposed to a braided suture material on pregnancy loss in women requiring a vaginal cervical cerclage. Design Superiority open randomised controlled trial. Setting Seventy-five maternity sites across the UK. Participants Women experiencing a singleton pregnancy requiring a cervical cerclage. Interventions Monofilament suture or braided suture. Main outcome measures The primary outcome was pregnancy loss (miscarriage and perinatal mortality, including any stillbirth or neonatal death in the first week of life). Secondary outcomes included the core outcome set for preterm birth. Methods Women were randomised on a 1 : 1 basis to monofilament or braided cerclage utilising a bespoke randomisation service with minimisation dependent on the site, indication for cerclage, intention to use progesterone and planned surgical technique. The inclusion criteria were three or more previous mid-trimester losses or preterm births, insertion of a cerclage in a previous pregnancy, a history of a mid-trimester loss or preterm birth with a shortened cervical length in the current pregnancy or in women who clinicians deemed at risk of preterm birth. The exclusion criteria were an emergency or rescue cerclage, age of < 18 years, being unable to give informed consent or the cerclage having to be placed abdominally. The original sample size was calculated based on a relative risk reduction of 41% from a pregnancy loss rate of 19% in the braided group to 11% in the monofilament group with 90% power and alpha at p = 0.05. The independent data monitoring committee noted a lower-than-anticipated pooled event rate within the trial and recommended an increase in sample size to 2050. The outcome data were collected using clinical record forms from the maternal and neonatal medical records and reported to Birmingham Clinical Trials Unit. Results A total of 2049 women were randomised, after withdrawals and loss to follow-up, data on 1005 women in the monofilament group and 993 women in the braided group were included. The baseline demographics between the groups were similar. There was no evidence of a difference in pregnancy loss rates between the monofilament and braided groups (80/1003 vs. 75/993; adjusted risk ratio: 1.05, 95% confidence interval: 0.79 to 1.40; adjusted risk difference: 0.002, 95% confidence interval: −0.02 to 0.03). Limitations The trial did not collect long-term paediatric outcomes. There were no safety concerns. Conclusions There was no evidence of a difference in pregnancy loss between a monofilament suture and a braided suture. Future work Long-term follow-up of neonates born within the C-STICH (cerclage suture type for an insufficient cervix and its effects on health outcomes) trial. Trial registration This trial is registered as ISRCTN15373349. Funding This award was funded by the National Institute for Health and Care Research (NIHR) Health Technology Assessment programme (NIHR award ref: 13/04/107) and is published in full in Health Technology Assessment; Vol. 28, No. 40. See the NIHR Funding and Awards website for further award information. Plain language summary Cervical cerclage is an operation performed in pregnancy to prevent miscarriage and preterm birth. A cervical cerclage is sometimes recommended in women who have had babies born prematurely before or who have had previous cervical surgery. A cerclage operation involves a stitch being inserted around the neck of the womb (cervix) to keep it closed during pregnancy and to prevent it opening prematurely. When performing the operation, the doctor can use different types of threads made of different materials. The threads used to perform the operation are called sutures. One suture type is a single strand or monofilament thread, and the other is a multifilament braided thread with lots of thin strands woven together. Some evidence has suggested that using a monofilament suture thread prevented pregnancy loss by preventing infection. Therefore, we performed a randomised controlled trial of the use of monofilament suture thread versus braided suture thread, aiming to reduce pregnancy loss in women who were having a cerclage as part of their routine care. The women consented to take part in the study and were randomly allocated to their cerclage performed with either a monofilament or braided suture thread; there was no other change to their planned pregnancy care. What happened in their pregnancy was recorded from their medical records and analysed. A total of 2049 women agreed to take part in the study and consented to the analysis of their pregnancy and neonatal outcomes. Cerclage suture type for an insufficient cervix and its effects on health outcomes showed that there was no difference in pregnancy loss between the two suture threads. There was decreased maternal sepsis and decreased chorioamnionitis (which is an infection inside the womb during labour) in the women who received a monofilament suture, which needs further investigation. Although more women who had a cerclage using the monofilament thread needed a small operation and an anaesthetic, often between 36 and 37 weeks, to remove the monofilament suture prior to a vaginal birth, there were no differences in the outcomes for their babies. Scientific summary Background Preterm birth and second trimester miscarriage is a significant cause of worldwide neonatal morbidity and mortality. The aetiology is complex and multifactorial with a number of causes, including cervical insufficiency. One treatment to prevent preterm birth and second trimester miscarriage caused by cervical insufficiency is the placement of a vaginal cervical cerclage (CC). A CC is the placement of a purse string suture thread around the cervix aiming to prevent pregnancy loss and preterm birth. A CC can be performed with either a monofilament suture thread or a braided suture thread. The choice of thread used during surgical operations is dependent on the properties of the thread, with braided threads being multifilament in nature with lots of single strands woven together, which predisposes it to potentially becoming colonised with pathogenic bacteria. A prior feasibility study suggested a difference in pregnancy loss outcomes between monofilament and braided suture threads and the acceptability of either thread for clinicians and women. Therefore, a randomised controlled trial was designed to explore this discrepancy, aiming to reduce pregnancy loss for women at high risk of preterm birth. Objectives The primary objective of the study was to examine the effectiveness of using a monofilament suture material compared to a braided suture material on minimising the risk of pregnancy loss in women requiring a vaginal CC. The secondary objectives of the study included exploring the impact of suture material on maternal and neonatal outcomes. Design A pragmatic open, parallel, multicentre, randomised superiority trial of monofilament versus braided suture type during CC to prevent pregnancy loss. Setting The study was conducted in hospital settings across the UK (75 sites) between 2015 and 2022. Participants Women were eligible for the trial if they required a vaginal CC as part of their routine care within their current pregnancy and they fulfilled the following eligibility criteria: Inclusion Singleton pregnancy. Indication for CC for either: a history of three or more previous mid-term losses or premature births (≤ 28 weeks), OR insertion of cervical sutures in previous pregnancies, OR a history of mid-trimester loss or premature birth with a shortened (≤ 25 mm) cervix, OR women whom clinicians deemed to be at risk of preterm birth either because of their history or because of the results of an ultrasound scan. Exclusion Had taken part in C-STICH previously. Aged < 18 years old at the time of presentation. Requiring a rescue cerclage. Unwilling or unable to give informed consent. Those in whom a cerclage was to be placed by any route other than vaginally (e.g. via an abdominal route). Immediate need for insertion of a suture. Membranes that had ruptured or were surfacing. Interventions Women were randomised at a 1 : 1 ratio via a secure internet facility to have their CC performed using either a monofilament or braided suture thread. Minimisation was employed to balance for the following: indication for cerclage, planned bladder dissection, intention to commence patient on progesterone and recruiting site. Outcome measures The primary outcome measure was pregnancy loss (miscarriage and perinatal mortality). Key secondary outcome: Time from conception to pregnancy end (any reason). Maternal outcomes: Miscarriage and previable neonatal death (defined as delivery < 24 weeks). Stillbirth (defined as intrauterine death ≥ 24 weeks). Gestation at delivery (in live births ≥ 24 weeks). Gestational age of < 28/< 32/< 37 weeks at delivery (in live births ≥ 24 weeks). Time from conception to onset of spontaneous vaginal delivery (in live births ≥ 24 weeks). Sepsis (at any time in pregnancy and until 7 days postnatal). Preterm prelabour rupture of membranes (PPROM). Mode of initiation of labour (spontaneous or induced). Mode of delivery (vaginal, operative vaginal or caesarean). Cerclage placement complications (cervical laceration/bleeding from cervix/ruptured membranes/bladder injury). Cerclage removal complications (cervical tears/need for anaesthetic/difficult to remove). Other maternal complications: vaginal bleeding/steroid use/chorioamnionitis/maternal pyrexia of 38°C (intrapartum/postnatal)/admission to high dependency unit (HDU) or intensive therapy unit (ITU) (pre/post delivery). Neonatal outcomes: Early neonatal death (defined as a death within 7 days after delivery) (in live births ≥ 24 weeks). Late neonatal death (defined as a death beyond 7 days and before 28 days after delivery) (in live births ≥ 24 weeks). Birth-weight centile adjusted for gestational age and sex (in live births ≥ 24 weeks). Small for gestational age and sex (< 10th centile, in live births ≥ 24 weeks). Resuscitation at birth (in live births ≥ 24 weeks). Additional care required [special care baby unit (SCBU)/neonatal intensive care unit (NICU)/HDU/transitional care] and length of stay in additional care (in live births ≥ 24 weeks). Antibiotics within 72 hours (in live births ≥ 24 weeks). Sepsis (clinically diagnosed/proven) (in live births ≥ 24 weeks). Early neurodevelopmental morbidity (severe abnormality on cranial ultrasound scan) (in live births ≥ 24 weeks). Respiratory support and days on respiratory support (in live births ≥ 24 weeks). Supplementary oxygen requirements at 36 weeks post menstrual age (in live births ≥ 24 weeks). Necrotising enterocolitis (Bell’s stage 2 or 3) (in live births ≥ 24 weeks). Retinopathy of prematurity requiring laser treatment (in live births ≥ 24 weeks). Disabilities (live births ≥ 24 weeks). Congenital anomalies (in live births ≥ 24 weeks). The core outcome set for preterm birth was fully collected within the trial. Sample size The original sample size was based on a meta-analysis of non-randomised studies, where the pooled pregnancy loss rate in the monofilament group was 7% compared to 19% in the braided group. To allow for the observational nature of these data, we powered the study to detect a more plausible relative reduction of 41% (19% with braided sutures to 11.2% with monofilament sutures) with 90% power (alpha = 0.05). We planned to recruit 900 women. As a result of some uncertainty around the sample size parameters, the data monitoring committee reviewed the pooled event rate throughout the study. The sample size was subsequently increased to 2050 women to allow for a lower-than-anticipated event rate in order to maintain sufficient power to detect the same relative risk reduction. The primary analysis was by intention to treat. Results The trial opened for recruitment in August 2015 and completed recruitment in January 2021. A total of 2049 women were randomised into the trial and data for analysis was available for 1003 women in the monofilament group and 993 women in the braided group. The baseline demographic characteristics of women in the monofilament and braided group were similar. There was no evidence of a difference in pregnancy loss rates between the monofilament and braided groups [80/1003 vs. 75/993; adjusted risk ratio (RR) 1.05, 95% confidence interval (CI) 0.79 to 1.40; adjusted risk difference 0.002, 95% CI −0.02 to 0.03]. There was no difference in conception to pregnancy end (median time to pregnancy end: 37.9 weeks vs. 38.0 weeks; adjusted hazard ratio 1.04, 95% CI 0.95 to 1.14). Regarding maternal outcomes there was a decrease in maternal sepsis in the monofilament group (4%) compared to the braided group (7%) (RR 0.58, 95% CI 0.40 to 0.82) and a decreased risk of chorioamnionitis in the monofilament group (3%) compared to the braided group (6%) (RR 0.45, 95% CI 0.29 to 0.71). There was no difference in any neonatal outcomes. CC removal complications showed an increase in the monofilament group (56% vs. 42%, RR 1.25, 95% CI 1.15 to 1.36), with increased difficulty of removal and an increased need for anaesthetic for removal being the most common complications. Conclusions There was no evidence of a difference between a monofilament suture thread and a braided suture for pregnancy outcomes. We can be relatively confident that using a monofilament suture is unlikely to have a substantial impact on pregnancy loss compared to a braided suture. The uncertainty around our comparative estimate for this outcome is at most 2% in favour of the monofilament in absolute terms. While this margin may not completely rule out missing a clinically important difference, we consider this scenario to be unlikely. Therefore, clinicians should consider the relative merits and disadvantages of the physical suture properties when selecting the material to perform a vaginal CC. The trial was robustly conducted with minimal limitations. An important strength of the study is the recognition early in the trial that the event rate was lower than anticipated and, therefore, the sample size was increased allowing the effectiveness of a monofilament versus braided suture thread to be fully evaluated. Trial registration This trial is registered as ISRCTN15373349. Funding This award was funded by the National Institute for Health and Care Research (NIHR) Health Technology Assessment programme (NIHR award ref: 13/04/107) and is published in full in Health Technology Assessment; Vol. 28, No. 40. See the NIHR Funding and Awards website for further award project information.
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- 2024
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19. Gastroschisis: A National Cohort Study to Describe Contemporary Surgical Strategies and Outcomes
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Owen, A, primary, Marven, S, additional, Johnson, P, additional, Kurinczuk, J, additional, Spark, P, additional, Draper, ES, additional, Brocklehurst, P, additional, and Knight, M, additional
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- 2023
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20. The development of a core outcome set for studies of pregnant women with multimorbidity
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Lee, Siang Ing, Hanley, Stephanie, Vowles, Zoe, Plachcinski, Rachel, Moss, Ngawai, Singh, Megha, Gale, Chris, Fagbamigbe, Adeniyi Francis, Azcoaga-Lorenzo, Amaya, Subramanian, Anuradhaa, Taylor, Beck, Nelson-Piercy, Catherine, Damase-Michel, Christine, Yau, Christopher, McCowan, Colin, O’Reilly, Dermot, Santorelli, Gillian, Dolk, Helen, Hope, Holly, Phillips, Katherine, Abel, Kathryn M., Eastwood, Kelly-Ann, Kent, Lisa, Locock, Louise, Loane, Maria, Mhereeg, Mohamed, Brocklehurst, Peter, McCann, Sharon, Brophy, Sinead, Wambua, Steven, Hemali Sudasinghe, Sudasing Pathirannehelage Buddhika, Thangaratinam, Shakila, Nirantharakumar, Krishnarajah, and Black, Mairead
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- 2023
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21. Intersectionality, vulnerability and foot health inequity
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Almeida, Joana, Brocklehurst, Jonathan, and Sharples, Adrienne
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- 2023
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22. ‘Whose role is it anyway?’ Experiences of community nurses in the delivery and support of oral health care for older people living at home: a grounded theory study
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Mitchell, Gary, Stark, Patrick, Wilson, Christine Brown, Tsakos, Georgios, Brocklehurst, Paul, Lappin, Caroline, Quinn, Barry, Holland, Nicola, and McKenna, Gerry
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- 2023
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23. Polypharmacy during pregnancy and associated risk factors: a retrospective analysis of 577 medication exposures among 1.5 million pregnancies in the UK, 2000-2019
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Subramanian, Anuradhaa, Azcoaga-Lorenzo, Amaya, Anand, Astha, Phillips, Katherine, Lee, Siang Ing, Cockburn, Neil, Fagbamigbe, Adeniyi Francis, Damase-Michel, Christine, Yau, Christopher, McCowan, Colin, O’Reilly, Dermot, Santorelli, Gillian, Hope, Holly, Kennedy, Jonathan I., Abel, Kathryn M., Eastwood, Kelly-Ann, Locock, Louise, Black, Mairead, Loane, Maria, Moss, Ngawai, Plachcinski, Rachel, Thangaratinam, Shakila, Brophy, Sinead, Agrawal, Utkarsh, Vowles, Zoe, Brocklehurst, Peter, Dolk, Helen, Nelson-Piercy, Catherine, and Nirantharakumar, Krishnarajah
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- 2023
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24. Evaluation of a co-designed educational e-resource about oral health for community nurses: study protocol
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Stark, Patrick, McKenna, Gerry, Wilson, Christine Brown, Tsakos, Georgios, Brocklehurst, Paul, Lappin, Caroline, Quinn, Barry, Holland, Nicola, and Mitchell, Gary
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- 2023
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25. The impact of different researchers to capture quality of life measures in a dementia randomised controlled trial
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Evans, Rachel, Brocklehurst, Paul, Ryan, Jean, and Hoare, Zoë
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- 2023
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26. Co‐production of health and social science research with vulnerable children and young people: A rapid review
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Jo Erwin, Lorna Burns, Urshla Devalia, Robert Witton, Jill Shawe, Hannah Wheat, Nick Axford, Janine Doughty, Sarah Kaddour, Abigail Nelder, Paul Brocklehurst, Skye Boswell, and Martha Paisi
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children and young people ,co‐production ,rapid review ,vulnerable ,Medicine (General) ,R5-920 ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background The term ‘care‐experienced’ refers to anyone who is currently in care or has been in care at any stage in their life. A complex interplay of factors leads to care‐experienced children and young people (CECYP) experiencing poorer oral health and access to dental care than their peers. A rapid review of the co‐production of health and social care research with vulnerable children and young people (CYP) was carried out to inform the development of a co‐produced research project exploring the oral health behaviours and access to dental services of CECYP. Here, ‘co‐production’ refers to the involvement of CYP in the planning or conduct of research with explicit roles in which they generate ideas, evidence and research outputs. Aim To learn how to meaningfully involve vulnerable CYP in the co‐production of health and social science research. Objectives To identify: Different approaches to facilitating the engagement of vulnerable CYP in co‐production of health and social science research; different activities carried out in such approaches, challenges to engaging vulnerable CYP in co‐production of health and social science research and ways to overcome them and areas of best practice in relation to research co‐production with vulnerable CYP. Search Strategy A rapid review of peer‐reviewed articles was conducted in six databases (MEDLINE, Embase, SocINDEX, CINAHL, PsycINFO and Web of Science) and grey literature to identify studies that engaged vulnerable CYP in co‐approaches to health and social research. Main Results Of 1394 documents identified in the search, 40 were included and analysed. A number of different approaches to co‐production were used in the studies. The CYP was involved in a range of activities, chiefly the development of data collection tools, data collection and dissemination. Individual challenges for CYP and researchers, practical and institutional factors and ethical considerations impacted the success of co‐production. Discussion and Conclusion Co‐production of health and social science with vulnerable CYP presents challenges to researchers and CYP calling for all to demonstrate reflexivity and awareness of biases, strengths and limitations. Used appropriately and well, co‐production offers benefits to researchers and CYP and can contribute to research that reflects the needs of vulnerable CYP. Adherence to the key principles of inclusion, safeguarding, respect and well‐being facilitates this approach. Patient and Public Contribution Members of our patient and public involvement and stakeholder groups contributed to the interpretation of the review findings. This manuscript was written together with a young care leaver, Skye Boswell, who is one of the authors. She contributed to the preparation of the manuscript, reviewing the findings and their interpretation.
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- 2024
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27. Field testing of recombinant subunit vaccines against Teladorsagia circumcincta in lambing ewes demonstrates a lack of efficacy in the face of a multi-species parasite challenge
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Alasdair J. Nisbet, Tom N. McNeilly, Daniel R. G. Price, Yvonne Bartley, Margaret Oliver, Dave McBean, Leigh Andrews, Gillian Mitchell, Rachael Duncan, Sarah Brocklehurst, and Fiona Kenyon
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parasitic gastroenteritis ,nematode vaccine ,teladorsagiasis ,field trial ,recombinant ,Infectious and parasitic diseases ,RC109-216 - Abstract
IntroductionWe previously demonstrated efficacy of an 8-antigen recombinant subunit vaccine against a single species homologous Teladorsagia circumcincta challenge in lambs and in lambing ewes in pen trials. We subsequently demonstrated efficacy of a simplified, 2-antigen, version of this vaccine in lambs in pen trials. Here, we test both vaccines in lambing ewes in a field setting.MethodsIn the work presented here, 12 adjacent plots were seeded with a mixed infection of several common species of parasitic nematodes of sheep in temperate regions, including T. circumcincta. Ewes (n = 144), in groups of 12, grazed for 2 years on these plots and, in the first year, six of these groups of ewes were vaccinated with a 2-antigen prototype vaccine against T. circumcincta prior to mating and then again prior to lambing. In the following year these ewes were immunised again, this time with the 8-antigen prototype vaccine against T. circumcincta prior to mating and then prior to lambing. Throughout both seasons antigen-specific serum antibody levels in ewes and faecal worm egg counts (FEC) in ewes and their lambs were monitored, along with nematode species diversity at lambing.ResultsImmunised ewes produced elevated serum antibody levels to each of the vaccine antigens following immunisation but their FEC levels were not statistically significantly impacted by vaccination with either vaccine. FEC levels were also not impacted in lambs co-grazing the pastures with these immunised ewes. Nematode species diversity was not significantly impacted by vaccination in either year.DiscussionThe immunosuppressive effects of co-infecting gastrointestinal nematodes, the absence of vaccine cross-protection against co-infecting species and the influence of the periparturient relaxation in immunity probably all contributed to the inability of either vaccine to protect against T. circumcincta infection in field trials in the work presented here.
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- 2024
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28. ‘Whose role is it anyway?’ Experiences of community nurses in the delivery and support of oral health care for older people living at home: a grounded theory study
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Gary Mitchell, Patrick Stark, Christine Brown Wilson, Georgios Tsakos, Paul Brocklehurst, Caroline Lappin, Barry Quinn, Nicola Holland, and Gerry McKenna
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Oral health ,Oral healthcare ,Older people ,Nursing ,Community nursing ,District nursing ,RT1-120 - Abstract
Abstract Background Older people who receive care at home are likely to require support with oral health care. Community nurses, who are also referred to as district or home care nurses, have an important role with this population. This is because they are the healthcare professionals who are most likely to encounter this population, who may also not be receiving regular dental care or oral health promotion. However, few studies have explored community nursing experiences in the delivery and support of oral healthcare for older people living at home. Methods A grounded theory approach was used to explore experiences of community nurses in the delivery and support of oral health care for older people living at home. Fifteen practising community nurses from the United Kingdom participated in one-to-one semi-structed interviews from May 2021 to December 2021. These interviews were audio-recorded, transcribed verbatim and analysed using constant comparative analysis. Ethical approval was obtained for this study prior to data collection. Results Four categories emerged from the data to support development of the core phenomena. These four categories were: (1) Education, in relation to what community nurses knew about oral health, (2) Practice, with regards to how community nurses delivered oral health care to older people in their own home, (3) Confidence, with consideration to the extent to which this supported or impeded community nurses in providing oral healthcare to older people and (4) Motivation, in terms of the extent to which community nurses thought they could or should influence future practice improvement in the area. The core category was (C) Uncertainty as it was both present and central across all four categories and related to community nursing understanding about their specific role, and the role of other professionals, with reference to oral health of their patients. Conclusions This study reveals community nurses' uncertainty in providing oral healthcare to older adults at home. Emphasising comprehensive and continuous oral health education can boost nurses' confidence in patient support. Interprofessional collaboration and clear role definitions with oral health professionals are crucial for improving oral health outcomes in this vulnerable population.
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- 2023
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29. The development of a core outcome set for studies of pregnant women with multimorbidity
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Siang Ing Lee, Stephanie Hanley, Zoe Vowles, Rachel Plachcinski, Ngawai Moss, Megha Singh, Chris Gale, Adeniyi Francis Fagbamigbe, Amaya Azcoaga-Lorenzo, Anuradhaa Subramanian, Beck Taylor, Catherine Nelson-Piercy, Christine Damase-Michel, Christopher Yau, Colin McCowan, Dermot O’Reilly, Gillian Santorelli, Helen Dolk, Holly Hope, Katherine Phillips, Kathryn M. Abel, Kelly-Ann Eastwood, Lisa Kent, Louise Locock, Maria Loane, Mohamed Mhereeg, Peter Brocklehurst, Sharon McCann, Sinead Brophy, Steven Wambua, Sudasing Pathirannehelage Buddhika Hemali Sudasinghe, Shakila Thangaratinam, Krishnarajah Nirantharakumar, Mairead Black, and on behalf of the MuM-PreDiCT Group
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Multimorbidity ,Multiple chronic conditions ,Multiple long-term conditions ,Pregnancy ,Maternity ,Outcome ,Medicine - Abstract
Abstract Background Heterogeneity in reported outcomes can limit the synthesis of research evidence. A core outcome set informs what outcomes are important and should be measured as a minimum in all future studies. We report the development of a core outcome set applicable to observational and interventional studies of pregnant women with multimorbidity. Methods We developed the core outcome set in four stages: (i) a systematic literature search, (ii) three focus groups with UK stakeholders, (iii) two rounds of Delphi surveys with international stakeholders and (iv) two international virtual consensus meetings. Stakeholders included women with multimorbidity and experience of pregnancy in the last 5 years, or are planning a pregnancy, their partners, health or social care professionals and researchers. Study adverts were shared through stakeholder charities and organisations. Results Twenty-six studies were included in the systematic literature search (2017 to 2021) reporting 185 outcomes. Thematic analysis of the focus groups added a further 28 outcomes. Two hundred and nine stakeholders completed the first Delphi survey. One hundred and sixteen stakeholders completed the second Delphi survey where 45 outcomes reached Consensus In (≥70% of all participants rating an outcome as Critically Important). Thirteen stakeholders reviewed 15 Borderline outcomes in the first consensus meeting and included seven additional outcomes. Seventeen stakeholders reviewed these 52 outcomes in a second consensus meeting, the threshold was ≥80% of all participants voting for inclusion. The final core outcome set included 11 outcomes. The five maternal outcomes were as follows: maternal death, severe maternal morbidity, change in existing long-term conditions (physical and mental), quality and experience of care and development of new mental health conditions. The six child outcomes were as follows: survival of baby, gestational age at birth, neurodevelopmental conditions/impairment, quality of life, birth weight and separation of baby from mother for health care needs. Conclusions Multimorbidity in pregnancy is a new and complex clinical research area. Following a rigorous process, this complexity was meaningfully reduced to a core outcome set that balances the views of a diverse stakeholder group.
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- 2023
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30. The decline and fall of the mammalian stem
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Neil Brocklehurst
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Mammal ,Synapsid ,Diversity ,Geographic range ,Sampling ,Medicine ,Biology (General) ,QH301-705.5 - Abstract
The mammalian crown originated during the Mesozoic and subsequently radiated into the substantial array of forms now extant. However, for about 100 million years before the crown’s origin, a diverse array of stem mammalian lineages dominated terrestrial ecosystems. Several of these stem lineages overlapped temporally and geographically with the crown mammals during the Mesozoic, but by the end of the Cretaceous crown mammals make up the overwhelming majority of the fossil record. The progress of this transition between ecosystems dominated by stem mammals and those dominated by crown mammals is not entirely clear, in part due to a distinct separation of analyses and datasets. Analyses of macroevolutionary patterns tend to focus on either the Mammaliaformes or the non-mammalian cynodonts, with little overlap in the datasets, preventing direct comparison of the diversification trends. Here I analyse species richness and biogeography of Synapsida as a whole during the Mesozoic, allowing comparison of the patterns in the mammalian crown and stem within a single framework. The analysis reveals the decline of the stem mammals occurred in two discrete phases. The first phase occurred between the Triassic and Middle Jurassic, during which the stem mammals were more restricted in their geographic range than the crown mammals, although within localities their species richness remained at levels seen previously. The second phase was a decline in species richness, which occurred during the Lower Cretaceous. The results show the decline of stem mammals, including tritylodontids and several mammaliaform groups, was not tied to a specific event, nor a gradual decline, but was instead a multiphase transition.
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- 2024
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31. Repeat prenatal corticosteroid prior to preterm birth: a systematic review and individual participant data meta-analysis for the PRECISE study group (prenatal repeat corticosteroid international IPD study group: assessing the effects using the best level of evidence) - study protocol
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Crowther Caroline A, Aghajafari Fariba, Askie Lisa M, Asztalos Elizabeth V, Brocklehurst Peter, Bubner Tanya K, Doyle Lex W, Dutta Sourabh, Garite Thomas J, Guinn Debra A, Hallman Mikko, Hannah Mary E, Hardy Pollyanna, Maurel Kimberly, Mazumder Premasish, McEvoy Cindy, Middleton Philippa F, Murphy Kellie E, Peltoniemi Outi M, Peters Dawn, Sullivan Lisa, Thom Elizabeth A, Voysey Merryn, Wapner Ronald J, Yelland Lisa, and Zhang Sasha
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Medicine - Abstract
Abstract Background The aim of this individual participant data (IPD) meta-analysis is to assess whether the effects of repeat prenatal corticosteroid treatment given to women at risk of preterm birth to benefit their babies are modified in a clinically meaningful way by factors related to the women or the trial protocol. Methods/Design The Prenatal Repeat Corticosteroid International IPD Study Group: assessing the effects using the best level of Evidence (PRECISE) Group will conduct an IPD meta-analysis. The PRECISE International Collaborative Group was formed in 2010 and data collection commenced in 2011. Eleven trials with up to 5,000 women and 6,000 infants are eligible for the PRECISE IPD meta-analysis. The primary study outcomes for the infants will be serious neonatal outcome (defined by the PRECISE International IPD Study Group as one of death (foetal, neonatal or infant); severe respiratory disease; severe intraventricular haemorrhage (grade 3 and 4); chronic lung disease; necrotising enterocolitis; serious retinopathy of prematurity; and cystic periventricular leukomalacia); use of respiratory support (defined as mechanical ventilation or continuous positive airways pressure or other respiratory support); and birth weight (Z-scores). For the children, the primary study outcomes will be death or any neurological disability (however defined by trialists at childhood follow up and may include developmental delay or intellectual impairment (developmental quotient or intelligence quotient more than one standard deviation below the mean), cerebral palsy (abnormality of tone with motor dysfunction), blindness (for example, corrected visual acuity worse than 6/60 in the better eye) or deafness (for example, hearing loss requiring amplification or worse)). For the women, the primary outcome will be maternal sepsis (defined as chorioamnionitis; pyrexia after trial entry requiring the use of antibiotics; puerperal sepsis; intrapartum fever requiring the use of antibiotics; or postnatal pyrexia). Discussion Data analyses are expected to commence in 2011 with results publicly available in 2012.
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- 2012
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32. Amniotic fluid embolism incidence, risk factors and outcomes: a review and recommendations
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Knight Marian, Berg Cynthia, Brocklehurst Peter, Kramer Michael, Lewis Gwyneth, Oats Jeremy, Roberts Christine L, Spong Catherine, Sullivan Elizabeth, van Roosmalen Jos, and Zwart Joost
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Gynecology and obstetrics ,RG1-991 - Abstract
Abstract Background Amniotic fluid embolism (AFE) is a rare but severe complication of pregnancy. A recent systematic review highlighted apparent differences in the incidence, with studies estimating the incidence of AFE to be more than three times higher in North America than Europe. The aim of this study was to examine population-based regional or national data from five high-resource countries in order to investigate incidence, risk factors and outcomes of AFE and to investigate whether any variation identified could be ascribed to methodological differences between the studies. Methods We reviewed available data sources on the incidence of AFE in Australia, Canada, the Netherlands, the United Kingdom and the USA. Where information was available, the risk factors and outcomes of AFE were examined. Results The reported incidence of AFE ranged from 1.9 cases per 100 000 maternities (UK) to 6.1 per 100 000 maternities (Australia). There was a clear distinction between rates estimated using different methodologies. The lowest estimated incidence rates were obtained through validated case identification (range 1.9-2.5 cases per 100 000 maternities); rates obtained from retrospective analysis of population discharge databases were significantly higher (range 5.5-6.1 per 100 000 admissions with delivery diagnosis). Older maternal age and induction of labour were consistently associated with AFE. Conclusions Recommendation 1: Comparisons of AFE incidence estimates should be restricted to studies using similar methodology. The recommended approaches would be either population-based database studies using additional criteria to exclude false positive cases, or tailored data collection using existing specific population-based systems. Recommendation 2: Comparisons of AFE incidence between and within countries would be facilitated by development of an agreed case definition and an agreed set of criteria to minimise inclusion of false positive cases for database studies. Recommendation 3: Groups conducting detailed population-based studies on AFE should develop an agreed strategy to allow combined analysis of data obtained using consistent methodologies in order to identify potentially modifiable risk factors. Recommendation 4: Future specific studies on AFE should aim to collect information on management and longer-term outcomes for both mothers and infants in order to guide best practice, counselling and service planning.
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- 2012
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33. The effectiveness of antenatal care programmes to reduce infant mortality and preterm birth in socially disadvantaged and vulnerable women in high-income countries: a systematic review
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Brocklehurst Peter, Kurinczuk Jennifer J, Oakley Laura, Hollowell Jennifer, and Gray Ron
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Gynecology and obstetrics ,RG1-991 - Abstract
Abstract Background Infant mortality has shown a steady decline in recent years but a marked socioeconomic gradient persists. Antenatal care is generally thought to be an effective method of improving pregnancy outcomes, but the effectiveness of specific antenatal care programmes as a means of reducing infant mortality in socioeconomically disadvantaged and vulnerable groups of women has not been rigorously evaluated. Methods We conducted a systematic review, focusing on evidence from high income countries, to evaluate the effectiveness of alternative models of organising or delivering antenatal care to disadvantaged and vulnerable groups of women vs. standard antenatal care. We searched Medline, Embase, Cinahl, PsychINFO, HMIC, CENTRAL, DARE, MIDIRS and a number of online resources to identify relevant randomised and observational studies. We assessed effects on infant mortality and its major medical causes (preterm birth, congenital anomalies and sudden infant death syndrome (SIDS)) Results We identified 36 distinct eligible studies covering a wide range of interventions, including group antenatal care, clinic-based augmented care, teenage clinics, prenatal substance abuse programmes, home visiting programmes, maternal care coordination and nutritional programmes. Fifteen studies had adequate internal validity: of these, only one was considered to demonstrate a beneficial effect on an outcome of interest. Six interventions were considered 'promising'. Conclusions There was insufficient evidence of adequate quality to recommend routine implementation of any of the programmes as a means of reducing infant mortality in disadvantaged/vulnerable women. Several interventions merit further more rigorous evaluation.
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- 2011
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34. NeOProM: Neonatal Oxygenation Prospective Meta-analysis Collaboration study protocol
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Schmidt Barbara, Finer Neil, Darlow Brian A, Brocklehurst Peter, Askie Lisa M, and Tarnow-Mordi William
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Pediatrics ,RJ1-570 - Abstract
Abstract Background The appropriate level of oxygenation for extremely preterm neonates (90%) have been reported to have greater rates of morbidity including retinopathy of prematurity and chronic lung disease. In order to answer this clinical dilemma reliably, large scale trial evidence is needed. Methods/Design To detect a small but important 4% increase in death or severe disability in survivors, over 5000 neonates would need to be recruited. As extreme prematurity affects 1% of births, such a project undertaken by one trial group would be prohibitively lengthy and expensive. Hence, the Neonatal Oxygenation Prospective Meta-analysis (NeOProM) Collaboration has been formed. A prospective meta-analysis (PMA) is one where studies are identified, evaluated, and determined to be eligible before the results of any included studies are known or published, thereby avoiding some of the potential biases inherent in standard, retrospective meta-analyses. This methodology provides the same strengths as a single large-scale multicentre randomised study whilst allowing greater pragmatic flexibility. The NeOProM Collaboration protocol (NCT01124331) has been agreed prior to the results of individual trials being available. This includes pre-specifying the hypotheses, inclusion criteria and outcome measures to be used. Each trial will first publish their respective results as they become available and the combined meta-analytic results, using individual patient data, will be published when all trials are complete. The primary outcome to be assessed is a composite outcome of death or major disability at 18 months - 2 years corrected age. Secondary outcomes include several measures of neonatal morbidity. The size of the combined dataset will allow the effect of the interventions to be explored more reliably with respect to pre-specified patient- and intervention-level characteristics. Discussion Results should be available by 2014.
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- 2011
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35. Evidence into practice: evaluating a child-centred intervention for diabetes medicine management The EPIC Project
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Rycroft-Malone Joanne, Russell Ian T, Lowes Lesley, Lewis Mary, Jackson Carol, Gregory John W, Carter Cynthia, Brocklehurst Peter, Allen Davina, Williams Anne, Noyes Jane P, Sharp Janice, Samuels Mark, Edwards Rhiannon, and Whitaker Rhiannon
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Pediatrics ,RJ1-570 - Abstract
Abstract Background There is a lack of high quality, child-centred and effective health information to support development of self-care practices and expertise in children with acute and long-term conditions. In type 1 diabetes, clinical guidelines indicate that high-quality, child-centred information underpins achievement of optimal glycaemic control with the aim of minimising acute readmissions and reducing the risk of complications in later life. This paper describes the development of a range of child-centred diabetes information resources and outlines the study design and protocol for a randomized controlled trial to evaluate the information resources in routine practice. The aim of the diabetes information intervention is to improve children and young people's quality of life by increasing self-efficacy in managing their type 1 diabetes. Methods/Design We used published evidence, undertook qualitative research and consulted with children, young people and key stakeholders to design and produce a range of child-centred, age-appropriate children's diabetes diaries, carbohydrate recording sheets, and assembled child-centred, age-appropriate diabetes information packs containing published information in a folder that can be personalized by children and young people with pens and stickers. Resources have been designed for children/young people 6-10; 11-15; and 16-18 years. To evaluate the information resources, we designed a pragmatic randomized controlled trial to assess the effectiveness, cost effectiveness, and implementation in routine practice of individually tailored, age-appropriate diabetes diaries and information packs for children and young people age 6-18years, compared with currently available standard practice. Children and young people will be stratified by gender, length of time since diagnosis (< 2years and > 2years) and age (6-10; 11-15; and 16-18 years). The following data will be collected at baseline, 3 and 6 months: PedsQL (generic, diabetes and parent versions), and EQ-5 D (parent and child); NHS resource use and process data (questionnaire and interview). Baseline and subsequent HbA1c measurements, blood glucose meter use, readings and insulin dose will be taken from routine test results and hand-held records when attending routine 3-4 monthly clinic visits. The primary outcome measure is diabetes self-efficacy and quality-of-life (Diabetes PedsQL). Secondary outcomes include: HbA1c, generic quality of life, routinely collected NHS/child-held data, costs, service use, acceptability and utility. Trial Registration ISRCTN17551624.
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- 2010
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36. The BRACELET Study: surveys of mortality in UK neonatal and paediatric intensive care trials
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Platt Martin, Tasker Robert C, Brocklehurst Peter, Harvey Sheila E, Snowdon Claire, Allen Elizabeth, and Elbourne Diana
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Medicine (General) ,R5-920 - Abstract
Abstract Background The subject of death and bereavement in the context of randomised controlled trials in neonatal or paediatric intensive care is under-researched. The objectives of this phase of the Bereavement and RAndomised ControlLEd Trials (BRACELET) Study were to determine trial activity in UK neonatal and paediatric intensive care (2002-06); numbers of deaths before hospital discharge; and variation in mortality across intensive care units and trials and to determine whether bereavement support policies were available within trials. These are essential prerequisites to considering the implications of future policies and practice subsequent to bereavement following a child's enrolment in a trial. Methods The units survey involved neonatal units providing level 2 or 3 care, and paediatric units providing level II care or above; the trials survey involved trials where allocation was randomized and interventions were delivered to intensive care patients, or to parents but designed to affect patient outcomes. Results Information was available from 191/220 (87%) neonatal units (149 level 2 or 3 care); and 28/32 (88%) paediatric units. 90/177 (51%) eligible responding units participated in one or more trial (76 neonatal, 14 paediatric) and 54 neonatal units and 6 paediatric units witnessed at least one death. 50 trials were identified (36 neonatal, 14 paediatric). 3,137 babies were enrolled in neonatal trials, 210 children in paediatric trials. Deaths ranged 0-278 (median [IQR interquartile range] 2 [1, 14.5]) per neonatal trial, 0-4 (median [IQR] 1 [0, 2.5]) per paediatric trial. 534 (16%) participants died post-enrolment: 522 (17%) in neonatal trials, 12 (6%) in paediatric trials. Trial participants ranged 1-236 (median [IQR] 21.5 [8, 39.8]) per neonatal unit, 1-53 (median [IQR] 11.5 [2.3, 33.8]) per paediatric unit. Deaths ranged 0-37 (median [IQR] 3.5 [0.3, 8.8]) per neonatal unit, 0-7 (median [IQR] 0.5 [0, 1.8]) per paediatric unit. Three trials had a formal policy for responding to bereavement. Conclusions A substantial number of deaths after trial enrolment were identified, distributed over many trials and units. Few trial teams had responses to bereavement in place. Those with the largest numbers of deaths might be best placed to collaborate in developing and assessing responses to bereavement.
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- 2010
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37. Neonatal ECMO Study of Temperature (NEST) - a randomised controlled trial
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Juszczak Edmund, Cowan Frances, Azzopardi Denis V, Firmin Richard, Field David J, and Brocklehurst Peter
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Pediatrics ,RJ1-570 - Abstract
Abstract Background Existing evidence indicates that once mature neonates with severe cardio-respiratory failure become eligible for Extra Corporeal Membrane Oxygenation (ECMO) their chances of intact survival are doubled if they actually receive ECMO. However, significant numbers survive with disability. NEST is a multi-centre randomised controlled trial designed to test whether, in neonates requiring ECMO, cooling to 34°C for the first 48 to 72 hours of their ECMO course leads to improved later health status. Infants allocated to the control group will receive ECMO at 37°C throughout their course, which is currently standard practice around the world. Health status of both groups will be assessed formally at 2 years corrected age. Methods/Design All infants recruited to the study will be cared for in one of the four United Kingdom (UK) ECMO centres. Babies who are thought to be eligible will be assessed by the treating clinician who will confirm eligibility, ensure that consent has been obtained and then randomise the baby using a web based system, based at the National Perinatal Epidemiology Unit (NPEU) Clinical Trials Unit. Trial registration. Babies allocated ECMO without cooling will receive ECMO at 37°C ± 0.2°C. Babies allocated ECMO with cooling will be managed at 34°C ± 0.2°C for up to 72 hours from the start of their ECMO run. The minimum duration of cooling will be 48 hours. Rewarming (to 37°C) will occur at a rate of no more than 0.5°C per hour. All other aspects of ECMO management will be identical. Primary outcome: Cognitive score from the Bayley Scales of Infant and Toddler Development, 3rd edition (Bayley-III) at age of 2 years (24 - 27 months). Discussion For the primary analysis, children will be analysed in the groups to which they are assigned, comparing the outcome of all babies allocated to "ECMO with cooling" with all those allocated to "ECMO" alone, regardless of deviation from the protocol or treatment received. For the primary outcome the analysis will compare the mean scores for each group of surviving babies. The rationale for this choice of primary analysis is to give a fair representation of the average ability of assessable children, accepting the limitation that excluding deaths might impose. The consistency of the effect of cooling on the group of babies recruited to the trial will be explored to see whether cooling is of particular help, or not, to specific subgroups of infants, using the statistical test of interaction. Therefore pre-specified subgroup analyses include: (i) whether the ECMO is veno-arterial or veno-venous; (ii) whether the child's oxygenation index at the time of recruitment is Trial Registration Current Controlled Trials ISRCTN72635512.
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- 2010
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38. Evaluation of a co-designed educational e-resource about oral health for community nurses: study protocol
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Patrick Stark, Gerry McKenna, Christine Brown Wilson, Georgios Tsakos, Paul Brocklehurst, Caroline Lappin, Barry Quinn, Nicola Holland, and Gary Mitchell
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Oral health ,Oral Healthcare ,Older people ,Nursing ,Community nursing ,District nursing ,RT1-120 - Abstract
Abstract Background Oral health is a crucial aspect of health and wellbeing for older people. Poor oral health has been found to significantly increase the risk of chronic health conditions and poor quality of life for older people. Nurses practicing in the community are well-placed to provide oral health care to older people in their own homes, yet there has been little research in this field to develop accessible support for them to do so. Previous literature, reviewed in an earlier phase of this work, revealed that there has, historically, been a paucity of oral health care education for nurses and very few educational resources have been developed in this field. Methods This study will evaluate an educational e-resource which has been co-designed by service users, carers and clinicians. In the first phase of research, evidence of promise will be evaluated by analysing quantitative data on community nurses’ oral health attitudes and self-efficacy for oral health assessments of older people. In the second phase of research, facilitators and barriers to community nurses’ provision of oral health care to older people and the acceptability of the educational e-resource will be evaluated. Discussion This research will investigate the potential of an educational e-resource to improve community nurses’ capabilities to deliver oral health care to older people in their own homes. This research will inform both future intervention design and understanding of community nurses’ knowledge and attitudes about oral health care. Facilitators and barriers to provision of this care for older people will also be explored.
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- 2023
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39. ADEPT - Abnormal Doppler Enteral Prescription Trial
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McCormick Kenny, Kempley Steve, Dorling Jon, Leaf Alison, Mannix Paul, and Brocklehurst Peter
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Pediatrics ,RJ1-570 - Abstract
Abstract Background Pregnancies complicated by abnormal umbilical artery Doppler blood flow patterns often result in the baby being born both preterm and growth-restricted. These babies are at high risk of milk intolerance and necrotising enterocolitis, as well as post-natal growth failure, and there is no clinical consensus about how best to feed them. Policies of both early milk feeding and late milk feeding are widely used. This randomised controlled trial aims to determine whether a policy of early initiation of milk feeds is beneficial compared with late initiation. Optimising neonatal feeding for this group of babies may have long-term health implications and if either of these policies is shown to be beneficial it can be immediately adopted into clinical practice. Methods and Design Babies with gestational age below 35 weeks, and with birth weight below 10th centile for gestational age, will be randomly allocated to an "early" or "late" enteral feeding regimen, commencing milk feeds on day 2 and day 6 after birth, respectively. Feeds will be gradually increased over 9-13 days (depending on gestational age) using a schedule derived from those used in hospitals in the Eastern and South Western Regions of England, based on surveys of feeding practice. Primary outcome measures are time to establish full enteral feeding and necrotising enterocolitis; secondary outcomes include sepsis and growth. The target sample size is 400 babies. This sample size is large enough to detect a clinically meaningful difference of 3 days in time to establish full enteral feeds between the two feeding policies, with 90% power and a 5% 2-sided significance level. Initial recruitment period was 24 months, subsequently extended to 38 months. Discussion There is limited evidence from randomised controlled trials on which to base decisions regarding feeding policy in high risk preterm infants. This multicentre trial will help to guide clinical practice and may also provide pointers for future research. Trial registration Current Controlled Trials ISRCTN: 87351483
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- 2009
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40. MRC ORACLE Children Study. Long term outcomes following prescription of antibiotics to pregnant women with either spontaneous preterm labour or preterm rupture of the membranes
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Salt Alison, Marlow Neil, Jones David, Brocklehurst Peter, Kenyon Sara, and Taylor David
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Gynecology and obstetrics ,RG1-991 - Abstract
Abstract Background The Medical Research Council (MRC) ORACLE trial evaluated the use of co-amoxiclav 375 mg and/or erythromycin 250 mg in women presenting with preterm rupture of membranes (PROM) ORACLE I or in spontaneous preterm labour (SPL) ORACLE II using a factorial design. The results showed that for women with a singleton baby with PROM the prescription of erythromycin is associated with improvements in short term neonatal outcomes, although co-amoxiclav is associated with prolongation of pregnancy, a significantly higher rate of neonatal necrotising enterocolitis was found in these babies. Prescription of erythromycin is now established practice for women with PROM. For women with SPL antibiotics demonstrated no improvements in short term neonatal outcomes and are not recommended treatment. There is evidence that both these conditions are associated with subclinical infection so perinatal antibiotic administration may reduce the risk of later disabilities, including cerebral palsy, although the risk may be increased through exposure to inflammatory cytokines, so assessment of longer term functional and educational outcomes is appropriate. Methods The MRC ORACLE Children's Study will follow up UK children at age 7 years born to 4809 women with PROM and the 4266 women with SPL enrolled in the earlier ORACLE trials. We will use a parental questionnaire including validated tools to assess disability and behaviour. We will collect the frequency of specific medical conditions: cerebral palsy, epilepsy, respiratory illness including asthma, diabetes, admission to hospital in last year and other diseases, as reported by parents. National standard test results will be collected to assess educational attainment at Key Stage 1 for children in England. Discussion This study is designed to investigate whether or not peripartum antibiotics improve health and disability for children at 7 years of age. Trial registration The ORACLE Trial and Children Study is registered in the Current Controlled Trials registry. ISCRTN 52995660
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- 2008
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41. The TOBY Study. Whole body hypothermia for the treatment of perinatal asphyxial encephalopathy: A randomised controlled trial
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Thoresen Marianne, Levene Malcolm, Halliday Henry, Edwards David, Brocklehurst Peter, Azzopardi Dennis, and Whitelaw Andrew
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Pediatrics ,RJ1-570 - Abstract
Abstract Background A hypoxic-ischaemic insult occurring around the time of birth may result in an encephalopathic state characterised by the need for resuscitation at birth, neurological depression, seizures and electroencephalographic abnormalities. There is an increasing risk of death or neurodevelopmental abnormalities with more severe encephalopathy. Current management consists of maintaining physiological parameters within the normal range and treating seizures with anticonvulsants. Studies in adult and newborn animals have shown that a reduction of body temperature of 3–4°C after cerebral insults is associated with improved histological and behavioural outcome. Pilot studies in infants with encephalopathy of head cooling combined with mild whole body hypothermia and of moderate whole body cooling to 33.5°C have been reported. No complications were noted but the group sizes were too small to evaluate benefit. Methods/Design TOBY is a multi-centre, prospective, randomised study of term infants after perinatal asphyxia comparing those allocated to "intensive care plus total body cooling for 72 hours" with those allocated to "intensive care without cooling". Full-term infants will be randomised within 6 hours of birth to either a control group with the rectal temperature kept at 37 +/- 0.2°C or to whole body cooling, with rectal temperature kept at 33–34°C for 72 hours. Term infants showing signs of moderate or severe encephalopathy +/- seizures have their eligibility confirmed by cerebral function monitoring. Outcomes will be assessed at 18 months of age using neurological and neurodevelopmental testing methods. Sample size At least 236 infants would be needed to demonstrate a 30% reduction in the relative risk of mortality or serious disability at 18 months. Recruitment was ahead of target by seven months and approvals were obtained allowing recruitment to continue to the end of the planned recruitment phase. 325 infants were recruited. Primary outcome Combined rate of mortality and severe neurodevelopmental impairment in survivors at 18 months of age. Neurodevelopmental impairment will be defined as any of: • Bayley mental developmental scale score less than 70 • Gross Motor Function Classification System Levels III – V • Bilateral cortical visual impairments Trial Registration Current Controlled Trials ISRCTN89547571
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- 2008
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42. Can we remunerate for prevention? A public health perspective
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R. Brocklehurst, Paul, Karki, Anup, Cope, Anwen, Barnes, Emma, Wilson, Mary, and Chestnutt, Ivor
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- 2024
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43. The effect of a monetary incentive on return of a postal health and development questionnaire: a randomised trial [ISRCTN53994660]
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Salt Alison, Taylor David, Jones David, Pike Katie, Kenyon Sara, Marlow Neil, and Brocklehurst Peter
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Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Postal questionnaires are widely used to collect data in healthcare research but a poor response rate may reduce the validity and reliability of results. There was a lack of evidence available relating to use of a monetary incentive to improve the response rate in the healthcare setting. Methods The MRC ORACLE Children Study is assessing the health and development of nearly 9000 seven year old children whose mothers' joined the MRC ORACLE Trial. We carried out a randomised controlled trial of inclusion of monetary incentive (five pound voucher redeemable at many high street stores) with the reminder questionnaire to parents. This trial took place between April 2002 and November 2003. When the parents were sent the reminder questionnaire about their child's health and development they were randomly assigned by concealed computer-generated allocation stratified by week of birthday to receive a five pound voucher or no incentive. The population were 722 non-responders to the initial mailing of a 12-page questionnaire. Main outcome measures: Difference in response rate between the two groups. Results Inclusion of the voucher with the reminder questionnaire resulted in a 11.7%(95% CI 4.7% to 18.6%) improvement in the response rate between the two groups. Conclusion This improvement in response rate and hence the validity and reliability of results obtained appears to be justified ethically and financially.
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- 2005
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44. Effect on survey response rate of hand written versus printed signature on a covering letter: randomised controlled trial [ISRCTN67566265]
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Ayers Sarah, Gates Simon, Tully Lucy, McKenzie-McHarg Kirstie, and Brocklehurst Peter
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Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background It is important that response rates to postal surveys are as high as possible to ensure that the results are representative and to maximise statistical power. Previous research has suggested that any personalisation of approach helps to improve the response rate. This experiment tested whether personalising questionnaires by hand signing the covering letter improved the response rate compared with a non-personalised group where the investigator's signature on the covering letter was scanned into the document and printed. Methods Randomised controlled trial. Questionnaires about surgical techniques of caesarean section were mailed to 3,799 Members and Fellows of the Royal College of Obstetricians and Gynaecologists resident in the UK. Individuals were randomly allocated to receive a covering letter with either a computer printed signature or a hand written signature. Two reminders were sent to non-respondents. The outcome measures were the proportion of questionnaires returned and their time to return. Results The response rate was 79.1% (1506/1905) in the hand-signed group and 78.4% (1484/1894) in the scanned and printed signature group. There was no detectable difference between the groups in response rate or time taken to respond. Conclusion No advantage was detected to hand signing the covering letter accompanying a postal questionnaire to health professionals.
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- 2005
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45. Detection and evaluation of signals associated with exposure to individual and combination of medications in pregnancy: a signal detection study protocol
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Christopher Yau, Catherine Nelson-Piercy, Krishnarajah Nirantharakumar, Anuradhaa Subramanian, Peter Brocklehurst, Sinead Brophy, Helen Dolk, Muhammad Usman, Jingya Wang, Colin McCowan, Holly Hope, Jonathan Kennedy, Siang Ing Lee, Amaya Azcoaga-Lorenzo, Gillian Santorelli, Mairead Black, Christine Damase-Michel, Ngawai Moss, Katherine Phillips, Kelly-Ann Eastwood, Kathryn Mary Abel, Lisa Kent, Adeniyi Fagbamigbe, Dermot OReilly, Steven Wambua, Megha Singh, Mohamed Mhereeg, Neil Cockburn, and Sudasing Pathirannehelage Buddhika Hemali Sudasinghe
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Medicine - Abstract
Introduction Considering the high prevalence of polypharmacy in pregnant women and the knowledge gap in the risk–benefit safety profile of their often-complex treatment plan, more research is needed to optimise prescribing. In this study, we aim to detect adverse and protective effect signals of exposure to individual and pairwise combinations of medications during pregnancy.Methods and analysis Using a range of real-world data sources from the UK, we aim to conduct a pharmacovigilance study to assess the safety of medications prescribed during the preconception period (3 months prior to conception) and first trimester of pregnancy. Women aged between 15 and 49 years with a record of pregnancy within the Clinical Practice Research Datalink (CPRD) Pregnancy Register, the Welsh Secure Anonymised Information Linkage (SAIL), the Scottish Morbidity Record (SMR) data sets and the Northern Ireland Maternity System (NIMATS) will be included. A series of case control studies will be conducted to estimate measures of disproportionality, detecting signals of association between a range of pregnancy outcomes and exposure to individual and combinations of medications. A multidisciplinary expert team will be invited to a signal detection workshop. By employing a structured framework, signals will be transparently assessed by each member of the team using a questionnaire appraising the signals on aspects of temporality, selection, time and measurement-related biases and confounding by underlying disease or comedications. Through group discussion, the expert team will reach consensus on each of the medication exposure–outcome signal, thereby excluding spurious signals, leaving signals suggestive of causal associations for further evaluation.Ethics and dissemination Ethical approval has been obtained from the Independent Scientific Advisory Committee, SAIL Information Governance Review Panel, University of St. Andrews Teaching and Research Ethics Committee and Office for Research Ethics Committees Northern Ireland (ORECNI) for access and use of CPRD, SAIL, SMR and NIMATS data, respectively.
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- 2023
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46. LAparoscopic Versus Abdominal hysterectomy (LAVA): protocol of a randomised controlled trial
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Laura Jones, Peter Brocklehurst, Rebecca Woolley, Paul Smith, Lee Middleton, Tracy Roberts, Ertan Saridogan, Lina Antoun, T Justin Clark, William McKinnon, Kevin Cooper, Sheriden Bevan, Jayne Fullard, and Monique Morgan
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Medicine - Abstract
Introduction There is uncertainty about the advantages and disadvantages of laparoscopic hysterectomy compared with abdominal hysterectomy, particularly the relative rate of complications of the two procedures. While uptake of laparoscopic hysterectomy has been slow, the situation is changing with greater familiarity, better training, better equipment and increased proficiency in the technique. Thus, a large, robust, multicentre randomised controlled trial (RCT) is needed to compare contemporary laparoscopic hysterectomy with abdominal hysterectomy to determine the safest and most cost-effective technique.Methods and analysis A parallel, open, non-inferiority, multicentre, randomised controlled, expertise-based surgery trial with integrated health economic evaluation and an internal pilot with an embedded qualitative process evaluation. A within trial-based economic evaluation will explore the cost-effectiveness of laparoscopic hysterectomy compared with open abdominal hysterectomy. We will aim to recruit 3250 women requiring a hysterectomy for a benign gynaecological condition and who were suitable for either laparoscopic or open techniques. The primary outcome is major complications up to six completed weeks postsurgery and the key secondary outcome is time from surgery to resumption of usual activities using the personalised Patient-Reported Outcomes Measurement Information System Physical Function questionnaire. The principal outcome for the economic evaluation is to be cost per QALY at 12 months’ postsurgery. A secondary analysis is to be undertaken to generate costs per major surgical complication avoided and costs per return to normal activities.Ethics and dissemination The study was approved by the West Midlands-Edgbaston Research Ethics Committee, 18 February 2021 (Ethics ref: 21/WM/0019). REC approval for the protocol version 2.0 dated 2 February 2021 was issued on 18 February 2021.We will present the findings in national and international conferences. We will also aim to publish the findings in high impact peer-reviewed journals. We will disseminate the completed paper to the Department of Health, the Scientific Advisory Committees of the RCOG, the Royal College of Nurses (RCN) and the BSGE.Trial registration number ISRCTN14566195.
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- 2023
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47. COVID-19: urgent actions, critical reflections and future relevance of ‘WaSH’: lessons for the current and future pandemics
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Howard, Guy, Bartram, Jamie, Brocklehurst, Clarissa, Colford, John M, Costa, Federico, Cunliffe, David, Dreibelbis, Robert, Eisenberg, Joseph Neil Spindel, Evans, Barbara, Girones, Rosina, Hrudey, Steve, Willetts, Juliet, and Wright, Caradee Y
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Prevention ,Generic health relevance ,Infection ,Clean Water and Sanitation ,Good Health and Well Being ,Aged ,Betacoronavirus ,COVID-19 ,Coronavirus Infections ,Humans ,Hygiene ,Pandemics ,Pneumonia ,Viral ,SARS-CoV-2 ,Sanitation ,Water ,coronavirus ,hygiene ,pandemics ,WaSH ,water ,Microbiology - Abstract
The COVID-19 pandemic placed hygiene at the centre of disease prevention. Yet, access to the levels of water supply that support good hand hygiene and institutional cleaning, our understanding of hygiene behaviours, and access to soap are deficient in low-, middle- and high-income countries. This paper reviews the role of water, sanitation and hygiene (WaSH) in disease emergence, previous outbreaks, combatting COVID-19 and in preparing for future pandemics. We consider settings where these factors are particularly important and identify key preventive contributions to disease control and gaps in the evidence base. Urgent substantial action is required to remedy deficiencies in WaSH, particularly the provision of reliable, continuous piped water on-premises for all households and settings. Hygiene promotion programmes, underpinned by behavioural science, must be adapted to high-risk populations (such as the elderly and marginalised) and settings (such as healthcare facilities, transport hubs and workplaces). WaSH must be better integrated into preparation plans and with other sectors in prevention efforts. More finance and better use of financing instruments would extend and improve WaSH services. The lessons outlined justify no-regrets investment by government in response to and recovery from the current pandemic; to improve day-to-day lives and as preparedness for future pandemics.
- Published
- 2020
48. A national initiative in data science for health: an evaluation of the UK Farr Institute
- Author
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Hemingway, H, Lyons, R, Li, Q, Buchan, I, Ainsworth, J, Pell, J, Morris, A, Barnes, Michael R, Bedford, Helen, Bennie, Marion, Blandford, Ann, Briggs, Andy, Brocklehurst, Peter, Brophy, Sinead, Brown, Gavin, Burton, Paul, Butler, Christopher, Capewell, Simon, Carpenter, James, Carroll, John, Cassell, Jackie A, Castillo, Fortunato, Catchpole, Mike, Caulfield, Mark, Colhoun, Helen, Coveney, Peter, Cunningham-Burley, Sarah, Custovic, Adnan, Deanfield, John, Denaxas, Spiros, Dennis, Michael, Dezateux, Carol, Dibben, Chris, Diggle, Peter, Dixon, Will, Dunn, Graham, Emam, Khaled El, Fone, David, Ford, David, Ford, Ian, Frank, John, Freemantle, Nick, Gabbe, Belinda, Gallacher, John, Gibson, Martin, Gilbert, Ruth, Gissler, Mika, Goble, Carol, Goldberg, Andy, Gravenor, Mike, Gunnell, David, Hannaford, Phil, Hayward, Andrew, Hickman, Matthew, Hingorani, Aroon, Holm, Soren, Holman, Cashel, John, Gareth, John, Ann, Jones, Kerina, Kalra, Dipak, Laurie, Graeme, Lewis, Shon, Lloyd, Keith, Lowe, Sarah, McCowan, Colin, Macleod, John, Martin, Richard M, Moore, Anthony, Moore, Laurence, Nazareth, Irwin, Nenadic, Goran, Paranjothy, Shantini, Parmar, Max, Pebody, Richard, Petersen, Steffen, Petersen, Irene, Pillay, Deenan, Preen, David, Pickett, Kate, Pritchard-Jones, Kathy, Przulj, Natasa, Renehan, Andrew, Roberts, Stephen, Robson, John, Rodgers, Sarah, Rossor, Martin, Russell, Ian, Shawe-Taylor, John, Sheikh, Aziz, Siebert, Stefan, Snooks, Helen, Sperrin, Matthew, Stephenson, Judith, Sullivan, Frank, Taylor, Chris, Taylor, Paul, Timmis, Adam, and Ward, Hester JT
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Information and Computing Sciences ,Library and Information Studies ,Health Sciences ,Generic health relevance ,Health sciences ,Human society ,Information and computing sciences - Abstract
ObjectiveTo evaluate the extent to which the inter-institutional, inter-disciplinary mobilisation of data and skills in the Farr Institute contributed to establishing the emerging field of data science for health in the UK.Design and outcome measuresWe evaluated evidence of six domains characterising a new field of science:defining central scientific challenges,demonstrating how the central challenges might be solved,creating novel interactions among groups of scientists,training new types of experts,re-organising universities,demonstrating impacts in society.We carried out citation, network and time trend analyses of publications, and a narrative review of infrastructure, methods and tools.SettingFour UK centres in London, North England, Scotland and Wales (23 university partners), 2013-2018.Results1. The Farr Institute helped define a central scientific challenge publishing a research corpus, demonstrating insights from electronic health record (EHR) and administrative data at each stage of the translational cycle in 593 papers with at least one Farr Institute author affiliation on PubMed. 2. The Farr Institute offered some demonstrations of how these scientific challenges might be solved: it established the first four ISO27001 certified trusted research environments in the UK, and approved more than 1000 research users, published on 102 unique EHR and administrative data sources, although there was no clear evidence of an increase in novel, sustained record linkages. The Farr Institute established open platforms for the EHR phenotyping algorithms and validations (>70 diseases, CALIBER). Sample sizes showed some evidence of increase but remained less than 10% of the UK population in primary care-hospital care linked studies. 3.The Farr Institute created novel interactions among researchers: the co-author publication network expanded from 944 unique co-authors (based on 67 publications in the first 30 months) to 3839 unique co-authors (545 papers in the final 30 months). 4. Training expanded substantially with 3 new masters courses, training >400 people at masters, short-course and leadership level and 48 PhD students. 5. Universities reorganised with 4/5 Centres established 27 new faculty (tenured) positions, 3 new university institutes. 6. Emerging evidence of impacts included: > 3200 citations for the 10 most cited papers and Farr research informed eight practice-changing clinical guidelines and policies relevant to the health of millions of UK citizens.ConclusionThe Farr Institute played a major role in establishing and growing the field of data science for health in the UK, with some initial evidence of benefits for health and healthcare. The Farr Institute has now expanded into Health Data Research (HDR) UK but key challenges remain including, how to network such activities internationally.
- Published
- 2020
49. COVID-19: Urgent actions, critical reflections and future relevance of ‘WaSH’: Lessons for the current and future pandemics
- Author
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Howard, G, Bartram, J, Brocklehurst, C, Colford, JM, Costa, F, Cunliffe, D, Dreibelbis, R, Eisenberg, JNS, Evans, B, Girones, R, Hrudey, S, Willetts, J, and Wright, CY
- Subjects
Environmental Science and Management ,Environmental Engineering ,Urban and Regional Planning - Abstract
The COVID-19 pandemic placed hygiene at the centre of disease prevention. Yet, access to the levels of water supply that support good hand hygiene and institutional cleaning, our understanding of hygiene behaviours, and access to soap are deficient in low-, middle-and high-income countries. This paper reviews the role of water, sanitation and hygiene (WaSH) in disease emergence, previous outbreaks, combatting COVID-19 and in preparing for future pandemics. We consider settings where these factors are particularly important and identify key preventive contributions to disease control and gaps in the evidence base. Urgent substantial action is required to remedy deficiencies in WaSH, particularly the provision of reliable, continuous piped water on-premises for all households and settings. Hygiene promotion programmes, underpinned by behavioural science, must be adapted to high-risk populations (such as the elderly and marginalised) and settings (such as healthcare facilities, transport hubs and workplaces). WaSH must be better integrated into preparation plans and with other sectors in prevention efforts. More finance and better use of financing instruments would extend and improve WaSH services. The lessons outlined justify no-regrets investment by government in response to and recovery from the current pandemic; to improve day-to-day lives and as preparedness for future pandemics.
- Published
- 2020
50. Intelligent sampling of high‐dimensional joint mobility space for analysis of articular function
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Peter J. Bishop, Robert J. Brocklehurst, and Stephanie E. Pierce
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articular function ,Dimetrodon ,evolutionary biomechanics ,joint mobility ,range of motion ,sampling algorithm ,Ecology ,QH540-549.5 ,Evolution ,QH359-425 - Abstract
Abstract Studies of joint structure and function have played a central role in understanding palaeobiology and major functional transitions in evolutionary history, where fossilized hard parts (e.g. bones) are often all that remain. Current digital methods for quantifying articular function depend on exhaustively sampling all possible joint poses, but this is computationally intensive, becoming prohibitively so with more degrees of freedom. This has impeded more sophisticated analyses or broader application of these methods to more diverse questions and species. The present study introduces ‘APSE’ (Accelerated Pose Searching with Electrostatics), an iterative algorithm for rapidly and intelligently sampling high‐dimensional joint pose space to quantify articular function and mobility. Key features of the algorithm are: known viable joint poses inform the search for new poses in successive generations; the search preferentially targets under‐explored regions of pose space, while avoiding over‐explored regions; large swaths of inviable pose space are never evaluated, thus minimizing wasted time; and parallelizability. The efficacy of the algorithm was benchmarked with diverse theoretical and biological joints. As a case study to demonstrate its utility, APSE was used to investigate mobility in the enigmatic shoulder joint of the extinct ‘pelycosaur’‐grade synapsid Dimetrodon, the function of which has been widely debated. APSE produces high‐dimensional joint mobility assessments with greater precision than state‐of‐the‐art exhaustive sampling methods. More viable poses are identified at a greater sampling density, but in a fraction of the time taken by current methods (hours, not days or weeks). Results for Dimetrodon shoulder mobility indicate strong coupling between most degrees of freedom across the joint's full range of motion, a stark contrast to the flexible shoulder of most extant tetrapods. APSE provides a time‐efficient means to quantitatively measure articular function and mobility, especially when more degrees of freedom are considered. By greatly reducing computational requirements, APSE lowers the barrier to researchers seeking to undertake more complex or more numerous analyses of articular function in modern and extinct animals. This will accelerate the pace of research in comparative or evolutionary analyses of joint and animal function.
- Published
- 2023
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