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7. Systematic analysis of drug combinations against Gram-positive bacteria

Author

Cacace, Elisabetta, Kim, Vladislav, Varik, Vallo, Knopp, Michael, Tietgen, Manuela, Brauer-Nikonow, Amber, Inecik, Kemal, Mateus, André, Milanese, Alessio, Mårli, Marita Torrissen, Mitosch, Karin, Selkrig, Joel, Brochado, Ana Rita, Kuipers, Oscar P., Kjos, Morten, Zeller, Georg, Savitski, Mikhail M., Göttig, Stephan, Huber, Wolfgang, and Typas, Athanasios

Published
2023
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12. Human(oid)

Author

Rodrigues, Paula, primary, Sousa, Ana, additional, Borges, Ana Pinto, additional, Brochado, Ana, additional, and Barbosa, Isabel, additional

Published
2023
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16. Drip and ship and mothership models of mechanical thrombectomy result in similar outcomes in acute ischemic stroke of the anterior circulation

Author

Brochado, Ana Pinedo, Muras, Antonio Cabrera, Oyarzun-Irazu, Iñigo, Rodriguez-Sainz, Aida, Caballero-Romero, Ivan, Aguilera-Irazabal, Borja, García-Sánchez, Juan Manuel, Sustatxa-Zárraga, Irene, Martínez-Condor, Daniel, Gutierrez-Albizuri, Clea, Bilbao-González, Amaia, Gómez-Beldarrain, Marian, and García-Moncó, Juan Carlos

Published
2022
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19. Metabolic and Regulatory Pathways Involved in the Anticancer Activity of Perillyl Alcohol: A Scoping Review of In Vitro Studies.

Author

Batista Brochado, Ana Carolina, Moraes, Júlia Alves de, Rodrigues de Oliveira, Bruna, De Souza Lima, Victor Hugo, Mariano, Eric Domingos, Karande, Sachin, Romasco, Tea, Leite, Paulo Emilio Correa, Mourão, Carlos Fernando, and Gomes Alves, Gutemberg

Subjects
*CHEMICAL alcohol metabolism, *PROTEINS, *RESEARCH funding, *PHOSPHORYLATION, *PHENOMENOLOGICAL biology, *ANTINEOPLASTIC agents, *CELLULAR signal transduction, *BIOCHEMISTRY, *DESCRIPTIVE statistics, *PLANT extracts, *SYSTEMATIC reviews, *MEDLINE, *ADENOSINE triphosphatase, *CELL death, *ONLINE information services
Abstract

Simple Summary: Perillyl alcohol is a natural compound derived from plants, and it has shown promise as an anti-cancer agent in various types of cancer. This review explores how POH affects cancer cells by examining its impact on metabolic and regulatory pathways, such as those involved in cell cycle regulation and apoptosis. By understanding these mechanisms, researchers can identify new opportunities for cancer treatment and consider POH as a candidate for drug repurposing. The findings from this research may help develop novel therapies that are more effective and potentially less toxic, providing new avenues for cancer treatment. Background/Objectives: Perillyl alcohol (POH), a plant-derived compound, has demonstrated anti-tumor activity across various human cancers. Understanding the regulatory pathways through which POH exerts its effects is crucial for identifying new therapeutic opportunities and exploring potential drug repositioning strategies. Therefore, this scoping review aims to provide a comprehensive overview of the metabolic and regulatory pathways involved in the anticancer effects of POH, based on in vitro evidence. Methods: Following the PRISMA-ScR 2018 guidelines, a systematic search was conducted in the PUBMED, Web of Science, and Scopus databases. Results: A total of 39 studies were included, revealing that POH exerts its biological effects by modulating several pathways, including the regulation of cyclins, CDKs, and p21, thereby affecting cell cycle progression. It inhibits growth and promotes cell death by attenuating AKT phosphorylation, reducing PARP-1 activity, increasing caspase activity and the FAS receptor and its ligand FASL. Additionally, POH reduces ERK phosphorylation, inhibits RAS protein isoprenylation, and decreases Na/K-ATPase activity. Conclusions: In conclusion, this review delineates the key regulatory pathways responsible for mediating the biological effects of POH in cancer. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Bioaccumulation of therapeutic drugs by human gut bacteria

Author

Klünemann, Martina, Andrejev, Sergej, Blasche, Sonja, Mateus, Andre, Phapale, Prasad, Devendran, Saravanan, Vappiani, Johanna, Simon, Bernd, Scott, Timothy A., Kafkia, Eleni, Konstantinidis, Dimitrios, Zirngibl, Katharina, Mastrorilli, Eleonora, Banzhaf, Manuel, Mackmull, Marie-Therese, Hövelmann, Felix, Nesme, Leo, Brochado, Ana Rita, Maier, Lisa, Bock, Thomas, Periwal, Vinita, Kumar, Manjeet, Kim, Yongkyu, Tramontano, Melanie, Schultz, Carsten, Beck, Martin, Hennig, Janosch, Zimmermann, Michael, Sévin, Daniel C., Cabreiro, Filipe, Savitski, Mikhail M., Bork, Peer, Typas, Athanasios, and Patil, Kiran R.

Published
2021
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26. Mapping Island Tourism Research

Author

Tiago, Flávio, Oliveira, Cristina, Brochado, Ana, Moro, Sérgio, Kavoura, Androniki, editor, Kefallonitis, Efstathios, editor, and Theodoridis, Prokopios, editor

Published
2020
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27. Journal Club

Author

Graw, Jochen, Engelhardt, Harald, Küsel, Kirsten, Kruck, Daniela, Tinnefeld, Philip, Sander, Johannes, Robatzek, Silke, Schäberle, Till F., Aichane, Khadija, Brochado, Ana Rita, and Gerlach, David

Published
2021
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31. Emergent survival and extinction of species within gut bacterial communities

Author

van den Berg, Naomi Iris, primary, Tramontano, Melanie, additional, Guan, Rui, additional, Andrejev, Sergej, additional, Blasche, Sonja, additional, Kim, Yongkyu, additional, Klunemann, Martina, additional, Gontao Brochado, Ana Rita, additional, Kalmar, Lajos, additional, Telzerow, Anja, additional, Bork, Peer, additional, Sevin, Daniel, additional, Typas, Athanasios, additional, and Patil, Kiran Raosaheb, additional

Published
2024
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34. Cytocompatibility of filling pastes by primary teeth root simulating model

Author

Pintor, Andréa Vaz Braga, Queiroz, Luciana Domênico, Sancas, Mariana Coutinho, Brochado, Ana Carolina Batista, Spoladore, Janaína, Fonseca-Gonçalves, Andréa, Fidalgo, Tatiana Kelly S., Freitas-Fernandes, Liana Bastos, Valente, Ana Paula, de Souza, Ivete Pomarico Ribeiro, Primo, Laura Guimarães, and Alves, Gutemberg Gomes

Published
2021
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35. Incidence and outcoMes of MInor stroke and high-risk traNsient ischEmic attack in NordicTus: IMMINENT study

Author

Ramos-Araque, María E., Castellanos, María del Mar, Naya Rios, Lucía, López-Cancio Martínez, Elena, Molina-Gil, Javier, Marta Moreno, Javier, Tejada Meza, Herbert, Temprano-Fernández, María Teresa, Antón-González, Celia, Vidal-de Francisco, Diana, Tejada García, Javier, Maciñeiras Montero, José Luis, Vicente Alba, Pablo, García-Sánchez, Juan Manuel, Aguilera-Irazabal, Borja, Martínez-Zabaleta, Maite, Díez, I.N., Pinedo Brochado, Ana, Azcune-Calle, Itxaso, Freijo Guerrero, María del Mar, Moreno-Estebanez, A., Palacio-Portilla, Enrique Jesús, Manrique Arregui, L., Rodríguez-Yáñez, Manuel, Santamaría Cadavid, María, Timiraos Fernández, Juan José, Herrero-Infante, Yolanda, Trejo-Gabriel-Galán, José María, Echavarría-Iñiguez, Ana, Tejero Juste, Carlos, Rodríguez-Montolio, Joana, Julián Villaverde, Francisco José, Moreno García, María Pilar, López-Mesonero, Luis, Redondo-Robles, Laura, Aymerich, Nuria, Korroza, J., Arenillas, Juan, Ramos-Araque, María E., Castellanos, María del Mar, Naya Rios, Lucía, López-Cancio Martínez, Elena, Molina-Gil, Javier, Marta Moreno, Javier, Tejada Meza, Herbert, Temprano-Fernández, María Teresa, Antón-González, Celia, Vidal-de Francisco, Diana, Tejada García, Javier, Maciñeiras Montero, José Luis, Vicente Alba, Pablo, García-Sánchez, Juan Manuel, Aguilera-Irazabal, Borja, Martínez-Zabaleta, Maite, Díez, I.N., Pinedo Brochado, Ana, Azcune-Calle, Itxaso, Freijo Guerrero, María del Mar, Moreno-Estebanez, A., Palacio-Portilla, Enrique Jesús, Manrique Arregui, L., Rodríguez-Yáñez, Manuel, Santamaría Cadavid, María, Timiraos Fernández, Juan José, Herrero-Infante, Yolanda, Trejo-Gabriel-Galán, José María, Echavarría-Iñiguez, Ana, Tejero Juste, Carlos, Rodríguez-Montolio, Joana, Julián Villaverde, Francisco José, Moreno García, María Pilar, López-Mesonero, Luis, Redondo-Robles, Laura, Aymerich, Nuria, Korroza, J., and Arenillas, Juan

Abstract

[Abstract] Background. Our primary aim was to investigate the incidence of non-cardioembolic minor acute ischemic stroke (AIS) and high-risk transient ischemic attack (TIA) and to identify predictors of stroke recurrence/death and severe bleeding. We also evaluated the rates of TIA, major vascular events, therapeutic management and predictors of poor functional outcome at 3 months in these patients. Methods. We retrospectively reviewed data from all stroke patients evaluated at the emergency department of 19 hospitals belonging to the NORDICTUS stroke network between July and December 2019. Consecutive patients with non-cardioembolic minor AIS (NIHSS ≤5) and high-risk TIA (ABCD2 ≥6 or ipsilateral stenosis ≥50%) were included. We recorded clinical, neuroimaging and therapeutic variables. Follow-up was performed at 30 and 90 days. Functional prognosis was assessed with the modified Rankin scale score (mRS). Results. Of 8275 patients, 1679 (20%) fulfilled IMMINENT criteria (1524 AIS/155 TIA), resulting in a global incidence of 48/100,000 inhabitants per-year. Recurrent stroke/death occurred in 73 (4.3%) patients. Extracranial ipsilateral stenosis (>50%): HR 1.999 (95% CI: 1.115–3.585, p = 0.020) and lack of hyperacute cerebral arterial assessment: HR 1.631 (95% CI: 1.009–2.636, p = 0.046) were associated with recurrent stroke/death at 90 days. Intracranial stenosis was associated with poor prognosis (p = 0.044). Reperfusion therapy was given to 147 (9%) and urgent double antiplatelet therapy (DAPT) to 320 (21%) patients. Conclusion. Twenty percent of our stroke patients presented as non-cardioembolic high-risk TIA or minor AIS. Extracranial ipsilateral stenosis and lack of hyperacute cerebral arterial assessment were predictors of stroke recurrence/death; intracranial stenosis was associated with poor outcome. Despite current recommendations there was a low penetrance of DAPT., [Resumen] Introducción. Nuestro objetivo principal fue investigar la incidencia de ictus minor no cardioembólico y ataque isquémico transitorio (AIT) de alto riesgo, además de identificar predictores de recurrencia de ictus/muerte y sangrado grave. Evaluamos los porcentajes de AIT, eventos vasculares mayores, manejo terapéutico y predictores de mal pronóstico funcional. Métodos. Estudio retrospectivo de todos los pacientes con ictus evaluados en urgencias de 19 hospitales de la RED NORDICTUS entre julio-diciembre de 2019. Se incluyeron pacientes consecutivos con ictus minor no cardioembólico (National Institute of Health Stroke Scale [NIHSS] ≤ 5) y AIT de alto riesgo (ABCD2 ≥ 6 o estenosis ipsilateral ≥ 50%). Registramos variables clínicas, de neuroimagen y terapéuticas. Se realizó seguimiento a los 30 y 90 días. El pronóstico funcional se determinó mediante la escala de Rankin modificada (mRS). Resultados. De 8.275 pacientes, 1.679 (20%) cumplieron criterios del estudio IMMINENT (1.524 ictus/155 AIT), la incidencia global fue 48/100.000 h habitantes-año. Hubo recurrencias de ictus/muerte en 73 (4,3%) pacientes. La estenosis extracraneal ipsilateral (>50%): HR 1.999 (IC 95%: 1.115-3.585); p = 0,020 y la ausencia de estudio cerebrovascular hiperagudo: HR 1.631 (IC 95%: 1.009-2.636); p = 0.046, fueron predictores de ictus/muerte a 90 días. La estenosis intracraneal se asoció a mal pronóstico (p = 0,044). Se administró terapia de reperfusión a 147 (9%) y doble antiagregación a 320 (21%) pacientes. Conclusión. Un 20% de los pacientes se presentó como ictus minor o AIT de alto riesgo. La estenosis extracraneal ipsilateral y la ausencia de estudio neurovascular hiperagudo fueron predictores de ictus/muerte; la estenosis intracraneal se asoció con mal pronóstico. A pesar de las recomendaciones actuales hay baja penetrancia de doble antiagregación.

Published
2024

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