180 results on '"Broad, Lisa M."'
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2. Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs
3. Current status of muscarinic M1 and M4 receptors as drug targets for neurodegenerative diseases
4. TRPA1 Antagonist LY3526318 Inhibits the Cinnamaldehyde‐Evoked Dermal Blood Flow Increase: Translational Proof of Pharmacology
5. The atypical ‘hippocampal’ glutamate receptor coupled to phospholipase D that controls stretch‐sensitivity in primary mechanosensory nerve endings is homomeric purely metabotropic GluK2
6. In vitro pharmacological and rat pharmacokinetic characterization of LY3020371, a potent and selective mGlu2/3 receptor antagonist
7. The atypical 'hippocampal' glutamate receptor coupled to phospholipase D that controls stretch‐sensitivity in primary mechanosensory nerve endings is homomeric purely metabotropic GluK2.
8. An Antibody Biosensor Establishes the Activation of the M1 Muscarinic Acetylcholine Receptor during Learning and Memory
9. M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss
10. Allosteric Potentiators of Neuronal Nicotinic Cholinergic Receptors: Potential Treatments for Neurodegenerative Disorders
11. Pharmacological profiling of native group II metabotropic glutamate receptors in primary cortical neuronal cultures using a FLIPR
12. In vitro characterisation of the novel positive allosteric modulators of the mGlu5 receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat
13. Pharmacological characterisation of ligand- and voltage-gated ion channels expressed in human iPSC-derived forebrain neurons
14. Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus
15. Triple-Addition Label-Free Assays for High-Throughput Screening of Muscarinic M1 Receptor Agonists, Antagonists, and Allosteric Modulators
16. Up-regulation of astrocyte metabotropic glutamate receptor 5 by amyloid-β peptide
17. Pharmacological profiling of the TRPV3 channel in recombinant and native assays
18. 5-I A-85380 and TC-2559 differentially activate heterologously expressed α4β2 nicotinic receptors
19. Partial agonists for α4β2 nicotinic receptors stimulate dopaminergic neuron firing with relatively enhanced maximal effects
20. From Structure to Clinic: Discovery of A M1 Muscarinic Acetylcholine Receptor Agonist for the Treatment of Memory Loss in Alzheimer's Disease
21. Acetylcholine modulates gamma frequency oscillations in the hippocampus by activation of muscarinic M1 receptors
22. Pharmacological analysis of intracellular Ca2+ signalling: problems and pitfalls
23. Stable expression and characterisation of a human α7 nicotinic subunit chimera: a tool for functional high-throughput screening
24. The nicotinic α4β2 receptor selective agonist, TC-2559, increases dopamine neuronal activity in the ventral tegmental area of rat midbrain slices
25. Expression and functional characterisation of a human chimeric nicotinic receptor with α6β4 properties
26. The nicotinic α4 β2 receptor selective agonist, TC-2559, increases dopamine neuronal activity in the ventral tegmental area of rat midbrain slices
27. Bitopic binding mode of an M1 muscarinic acetylcholine receptor agonist associated with adverse clinical trial outcomes
28. PSAB-OFP, a selective α7 nicotinic receptor agonist, is also a potent agonist of the 5-HT 3 receptor
29. Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus
30. Role of the Phospholipase C-Inositol 1,4,5-Trisphosphate Pathway in Calcium Release-activated Calcium Current and Capacitative Calcium Entry
31. Signaling Pathways Underlying Muscarinic Receptor-induced [Ca2+]i Oscillations in HEK293 Cells
32. Stable Activation of Single Ca2+ Release-activated Ca2+ Channels in Divalent Cation-free Solutions
33. Mutual Antagonism of Calcium Entry by Capacitative and Arachidonic Acid-mediated Calcium Entry Pathways
34. Identification and pharmacological profile of SPP1, a potent, functionally selective and brain penetrant agonist at muscarinic M1 receptors
35. In Vitro Pharmacological Characterization and In Vivo Validation of LSN3172176 a Novel M1 Selective Muscarinic Receptor Agonist Tracer Molecule for Positron Emission Tomography
36. Synthesis and Pharmacological Characterization of C4β-Amide-Substituted 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1S,2S,4S,5R,6S)-2-Amino-4-[(3-methoxybenzoyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2794193), a Highly Potent and Selective mGlu3 Receptor Agonist
37. Role of the Inositol 1,4,5-Trisphosphate Receptor in Ca2+ Feedback Inhibition of Calcium Release-activated Calcium Current (Icrac)
38. In vitro pharmacological and rat pharmacokinetic characterization of LY3020371, a potent and selective mGlu 2/3 receptor antagonist
39. Activation of transient receptor potential ankyrin 1 induces CGRP release from spinal cord synaptosomes
40. Identification and pharmacological profile of SPP1, a potent, functionally selective and brain penetrant agonist at muscarinic M1 receptors.
41. M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss
42. Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1S,2S,5R,6S-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures
43. 123I-Iododexetimide Preferentially Binds to the Muscarinic Receptor Subtype M1 In Vivo
44. Allosteric Potentiators of Neuronal Nicotinic Cholinergic Receptors: Potential Treatments for Neurodegenerative Disorders
45. Bitopic Binding Mode of an M1Muscarinic Acetylcholine Receptor Agonist Associated with Adverse Clinical Trial Outcomes
46. TRPV3 in Drug Development.
47. TRP channels as emerging targets for pain therapeutics
48. Sazetidine-A Is a Potent and Selective Agonist at Native and Recombinant α4β2 Nicotinic Acetylcholine Receptors
49. 123I-Iododexetimide Preferentially Binds to the Muscarinic Receptor Subtype M1 In Vivo.
50. Epibatidine isomers and analogues: Structure–activity relationships
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